HSPD1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.70355602
2regulation of immunoglobulin secretion (GO:0051023)5.44338061
3DNA deamination (GO:0045006)5.38211304
4chaperone-mediated protein transport (GO:0072321)5.08575010
5proteasome assembly (GO:0043248)5.07526180
6regulation of isotype switching to IgG isotypes (GO:0048302)4.98218200
7regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.91113793
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.84092693
9regulation of regulatory T cell differentiation (GO:0045589)4.59886746
10cytidine metabolic process (GO:0046087)4.51837503
11cytidine catabolic process (GO:0006216)4.51837503
12cytidine deamination (GO:0009972)4.51837503
13positive regulation of interleukin-17 production (GO:0032740)4.46239147
14GTP biosynthetic process (GO:0006183)4.24701661
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.20056204
16rRNA modification (GO:0000154)4.08631428
17transcription from mitochondrial promoter (GO:0006390)4.05995319
18water-soluble vitamin biosynthetic process (GO:0042364)4.05579061
19pyrimidine ribonucleoside catabolic process (GO:0046133)3.92646436
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.81943958
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.81943958
22NADH dehydrogenase complex assembly (GO:0010257)3.81943958
23cullin deneddylation (GO:0010388)3.80710543
24UTP biosynthetic process (GO:0006228)3.79881539
25ATP synthesis coupled proton transport (GO:0015986)3.74730959
26energy coupled proton transport, down electrochemical gradient (GO:0015985)3.74730959
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74306502
28DNA double-strand break processing (GO:0000729)3.71818946
29rRNA methylation (GO:0031167)3.64775475
30protein deneddylation (GO:0000338)3.63613379
31RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.60453484
32tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.60453484
33CTP biosynthetic process (GO:0006241)3.59095191
34CTP metabolic process (GO:0046036)3.59095191
35protein complex biogenesis (GO:0070271)3.58978680
36mitochondrial respiratory chain complex assembly (GO:0033108)3.58902424
37positive regulation of isotype switching (GO:0045830)3.58438638
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.56886168
39DNA catabolic process, exonucleolytic (GO:0000738)3.56823165
40regulation of cellular amino acid metabolic process (GO:0006521)3.55443101
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.51919655
42positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48152123
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.44889179
44pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.41600095
45negative regulation of ligase activity (GO:0051352)3.41396604
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41396604
47pseudouridine synthesis (GO:0001522)3.40733600
48pyrimidine ribonucleoside metabolic process (GO:0046131)3.40625153
49UTP metabolic process (GO:0046051)3.38178484
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36201620
51regulation of chronic inflammatory response (GO:0002676)3.33273823
52signal peptide processing (GO:0006465)3.32730148
53pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.30369907
54ribosome assembly (GO:0042255)3.29299282
55intracellular protein transmembrane import (GO:0044743)3.26023774
56positive regulation of DNA recombination (GO:0045911)3.24362779
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.20097062
58pyrimidine ribonucleotide biosynthetic process (GO:0009220)3.19834106
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16394123
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.15800243
61regulation of double-strand break repair via homologous recombination (GO:0010569)3.14422711
62signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.11959593
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.11959593
64signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.11959593
65pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.10756748
66transcription elongation from RNA polymerase III promoter (GO:0006385)3.09077282
67termination of RNA polymerase III transcription (GO:0006386)3.09077282
68intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07546580
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07546580
70tRNA processing (GO:0008033)3.05122277
71rRNA processing (GO:0006364)3.04028376
72positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.03396264
73intracellular protein transmembrane transport (GO:0065002)3.02314520
74pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.02247215
75signal transduction involved in DNA damage checkpoint (GO:0072422)3.01359566
76signal transduction involved in DNA integrity checkpoint (GO:0072401)3.01359566
77postreplication repair (GO:0006301)3.00672191
78guanosine-containing compound biosynthetic process (GO:1901070)2.98979789
79signal transduction involved in cell cycle checkpoint (GO:0072395)2.98384444
80double-strand break repair via homologous recombination (GO:0000724)2.97443107
81protein targeting to mitochondrion (GO:0006626)2.97285921
82recombinational repair (GO:0000725)2.96334565
83positive regulation of ligase activity (GO:0051351)2.93711141
84protein-cofactor linkage (GO:0018065)2.91541553
85tRNA metabolic process (GO:0006399)2.89755019
86rRNA metabolic process (GO:0016072)2.89565445
87somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.89130085
88isotype switching (GO:0045190)2.89130085
89somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.89130085
90spliceosomal complex assembly (GO:0000245)2.88920529
91negative regulation of B cell apoptotic process (GO:0002903)2.88446052
92telomere maintenance via semi-conservative replication (GO:0032201)2.88424510
93nucleoside diphosphate phosphorylation (GO:0006165)2.86895950
94telomere maintenance via recombination (GO:0000722)2.86800118
95pyrimidine ribonucleotide metabolic process (GO:0009218)2.84701869
96peptidyl-histidine modification (GO:0018202)2.81334145
97positive regulation of defense response to virus by host (GO:0002230)2.80494856
98amino acid activation (GO:0043038)2.80395719
99tRNA aminoacylation (GO:0043039)2.80395719
100tRNA aminoacylation for protein translation (GO:0006418)2.80231685

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.23461904
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.16244225
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.58895189
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.05522793
5E2F7_22180533_ChIP-Seq_HELA_Human3.58956841
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.49440161
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.38315899
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.28235055
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.14687388
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.11943638
11VDR_23849224_ChIP-Seq_CD4+_Human3.05044548
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.74218604
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69602803
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67554256
15FOXP3_21729870_ChIP-Seq_TREG_Human2.54436129
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.53776630
17ELK1_19687146_ChIP-ChIP_HELA_Human2.52385858
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44554028
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39858474
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.28718009
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.21243247
22VDR_22108803_ChIP-Seq_LS180_Human2.14262029
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.13026981
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07790601
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.05531943
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05145163
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00330797
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92332688
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91675629
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83648124
31ZNF274_21170338_ChIP-Seq_K562_Hela1.83401016
32DCP1A_22483619_ChIP-Seq_HELA_Human1.80134812
33TTF2_22483619_ChIP-Seq_HELA_Human1.78487276
34MYC_18940864_ChIP-ChIP_HL60_Human1.77950788
35GABP_19822575_ChIP-Seq_HepG2_Human1.74931097
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68743137
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.66093568
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.65487333
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65089554
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61834931
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58279829
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57593712
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53333934
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49940296
45XRN2_22483619_ChIP-Seq_HELA_Human1.47768351
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47572002
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.46353132
48EWS_26573619_Chip-Seq_HEK293_Human1.45503098
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43590053
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41650395
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40389784
52TAF15_26573619_Chip-Seq_HEK293_Human1.40310383
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33725269
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30118060
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.28898641
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27336993
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24720465
58TP53_22573176_ChIP-Seq_HFKS_Human1.20970931
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17522171
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15400647
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11904463
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10930690
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09787315
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.09409899
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08746479
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06366355
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06003316
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.05276646
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04562294
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01141471
71EZH2_27294783_Chip-Seq_NPCs_Mouse0.98585515
72FUS_26573619_Chip-Seq_HEK293_Human0.98095083
73CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95834012
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95478470
75PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93599205
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93325909
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93050754
78MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90698801
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90641550
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89644928
81KDM5A_27292631_Chip-Seq_BREAST_Human0.89562214
82POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88705405
83GATA3_26560356_Chip-Seq_TH2_Human0.87227478
84P300_19829295_ChIP-Seq_ESCs_Human0.84679516
85POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84017831
86ERG_20517297_ChIP-Seq_VCAP_Human0.83676226
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83221339
88AR_20517297_ChIP-Seq_VCAP_Human0.83144991
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82642845
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.80683930
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80683930
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.79657608
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78453567
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.76617708
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76442628
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76232703
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.76166545
98NANOG_19829295_ChIP-Seq_ESCs_Human0.75323665
99SOX2_19829295_ChIP-Seq_ESCs_Human0.75323665
100LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75236230

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.21307951
2MP0008058_abnormal_DNA_repair2.95419535
3MP0005671_abnormal_response_to2.93135577
4MP0008057_abnormal_DNA_replication2.83860208
5MP0008877_abnormal_DNA_methylation2.83692386
6MP0010094_abnormal_chromosome_stability2.66818758
7MP0006292_abnormal_olfactory_placode2.64612625
8MP0008872_abnormal_physiological_respon2.56371832
9MP0002163_abnormal_gland_morphology2.54200870
10MP0004147_increased_porphyrin_level2.51034171
11MP0001873_stomach_inflammation2.28586037
12MP0001853_heart_inflammation2.24605933
13MP0003718_maternal_effect2.16868110
14MP0002837_dystrophic_cardiac_calcinosis2.07495233
15MP0008875_abnormal_xenobiotic_pharmacok2.02708476
16MP0003186_abnormal_redox_activity1.98639282
17MP0004957_abnormal_blastocyst_morpholog1.97806558
18MP0003693_abnormal_embryo_hatching1.95287997
19MP0003786_premature_aging1.93132479
20MP0003806_abnormal_nucleotide_metabolis1.92720111
21MP0005387_immune_system_phenotype1.72131376
22MP0001790_abnormal_immune_system1.72131376
23MP0009785_altered_susceptibility_to1.70545704
24MP0002148_abnormal_hypersensitivity_rea1.70000048
25MP0000372_irregular_coat_pigmentation1.69966949
26MP0002736_abnormal_nociception_after1.68499476
27MP0005379_endocrine/exocrine_gland_phen1.66931210
28MP0009333_abnormal_splenocyte_physiolog1.66356567
29MP0002938_white_spotting1.64525790
30MP0000465_gastrointestinal_hemorrhage1.64066441
31MP0002138_abnormal_hepatobiliary_system1.63213777
32MP0004782_abnormal_surfactant_physiolog1.60822502
33MP0005645_abnormal_hypothalamus_physiol1.48772241
34MP0003195_calcinosis1.43947544
35MP0003878_abnormal_ear_physiology1.42875602
36MP0005377_hearing/vestibular/ear_phenot1.42875602
37MP0006072_abnormal_retinal_apoptosis1.41712125
38MP0006036_abnormal_mitochondrial_physio1.37884562
39MP0001984_abnormal_olfaction1.37744015
40MP0001968_abnormal_touch/_nociception1.33047139
41MP0004742_abnormal_vestibular_system1.30839727
42MP0000685_abnormal_immune_system1.30388930
43MP0003763_abnormal_thymus_physiology1.29948166
44MP0003221_abnormal_cardiomyocyte_apopto1.24390880
45MP0002876_abnormal_thyroid_physiology1.22366950
46MP0003077_abnormal_cell_cycle1.21217156
47MP0005084_abnormal_gallbladder_morpholo1.20386813
48MP0003300_gastrointestinal_ulcer1.19499466
49MP0008932_abnormal_embryonic_tissue1.19012531
50MP0001800_abnormal_humoral_immune1.18522826
51MP0003111_abnormal_nucleus_morphology1.16991371
52MP0001986_abnormal_taste_sensitivity1.16594442
53MP0002405_respiratory_system_inflammati1.14442963
54MP0004142_abnormal_muscle_tone1.12016475
55MP0001919_abnormal_reproductive_system1.11512467
56MP0002277_abnormal_respiratory_mucosa1.10027006
57MP0005253_abnormal_eye_physiology1.09483380
58MP0005187_abnormal_penis_morphology1.07932356
59MP0009697_abnormal_copulation1.07139305
60MP0002234_abnormal_pharynx_morphology1.06566375
61MP0006035_abnormal_mitochondrial_morpho1.03470631
62MP0005000_abnormal_immune_tolerance1.03224227
63MP0002102_abnormal_ear_morphology1.03132591
64MP0001485_abnormal_pinna_reflex1.01464564
65MP0001529_abnormal_vocalization1.01351120
66MP0005389_reproductive_system_phenotype0.98859651
67MP0008873_increased_physiological_sensi0.97943790
68MP0008789_abnormal_olfactory_epithelium0.96914106
69MP0004145_abnormal_muscle_electrophysio0.96189294
70MP0003567_abnormal_fetal_cardiomyocyte0.94380523
71MP0004215_abnormal_myocardial_fiber0.93965305
72MP0000703_abnormal_thymus_morphology0.92260196
73MP0002693_abnormal_pancreas_physiology0.92243651
74MP0000689_abnormal_spleen_morphology0.92087408
75MP0005551_abnormal_eye_electrophysiolog0.90340247
76MP0005410_abnormal_fertilization0.90001990
77MP0005636_abnormal_mineral_homeostasis0.89316044
78MP0002254_reproductive_system_inflammat0.87613537
79MP0001188_hyperpigmentation0.87005610
80MP0001348_abnormal_lacrimal_gland0.86262183
81MP0005167_abnormal_blood-brain_barrier0.84781880
82MP0010307_abnormal_tumor_latency0.83060708
83MP0002723_abnormal_immune_serum0.81162915
84MP0010155_abnormal_intestine_physiology0.80970912
85MP0008995_early_reproductive_senescence0.79574339
86MP0003011_delayed_dark_adaptation0.79205959
87MP0002210_abnormal_sex_determination0.76831251
88MP0004043_abnormal_pH_regulation0.76487003
89MP0002722_abnormal_immune_system0.74255530
90MP0002420_abnormal_adaptive_immunity0.70783337
91MP0003936_abnormal_reproductive_system0.69553989
92MP0002160_abnormal_reproductive_system0.68010472
93MP0002398_abnormal_bone_marrow0.67123397
94MP0001845_abnormal_inflammatory_respons0.66256838
95MP0000049_abnormal_middle_ear0.64763880
96MP0001819_abnormal_immune_cell0.64621977
97MP0005395_other_phenotype0.63452678
98MP0009765_abnormal_xenobiotic_induced0.62900084
99MP0005365_abnormal_bile_salt0.62884929
100MP0001929_abnormal_gametogenesis0.62021093

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.56650273
2Abnormality of the labia minora (HP:0012880)4.21960992
3Acute encephalopathy (HP:0006846)4.07695746
4Increased hepatocellular lipid droplets (HP:0006565)4.02213259
5Abnormal mitochondria in muscle tissue (HP:0008316)4.01088194
6Mitochondrial inheritance (HP:0001427)3.99396862
7Increased CSF lactate (HP:0002490)3.96982249
8Lipid accumulation in hepatocytes (HP:0006561)3.82671327
9Progressive macrocephaly (HP:0004481)3.67466050
103-Methylglutaconic aciduria (HP:0003535)3.32342811
11Methylmalonic acidemia (HP:0002912)3.27940338
12Hypoplasia of the pons (HP:0012110)3.22068763
13Abnormality of the pons (HP:0007361)3.21635323
14Increased serum pyruvate (HP:0003542)3.14888676
15IgG deficiency (HP:0004315)3.08301268
16Hepatocellular necrosis (HP:0001404)3.04973834
17Chromsome breakage (HP:0040012)3.00090005
18Methylmalonic aciduria (HP:0012120)2.99333902
19Increased serum lactate (HP:0002151)2.95269758
20Abnormal number of erythroid precursors (HP:0012131)2.89630045
21Cerebral edema (HP:0002181)2.88533914
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.86848709
23Abnormality of alanine metabolism (HP:0010916)2.86848709
24Hyperalaninemia (HP:0003348)2.86848709
25Stomatitis (HP:0010280)2.83223800
26Hepatic necrosis (HP:0002605)2.82155726
27Back pain (HP:0003418)2.79443112
28Pancreatic cysts (HP:0001737)2.76414013
29Renal Fanconi syndrome (HP:0001994)2.68542875
30Constricted visual fields (HP:0001133)2.63246472
31Abnormality of glycolysis (HP:0004366)2.62148107
32Birth length less than 3rd percentile (HP:0003561)2.57632912
33Cystic liver disease (HP:0006706)2.55604036
34Increased intramyocellular lipid droplets (HP:0012240)2.53724186
35Lactic acidosis (HP:0003128)2.49895076
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46124690
37Optic disc pallor (HP:0000543)2.44063391
38Oral leukoplakia (HP:0002745)2.43831109
39Abnormality of cells of the erythroid lineage (HP:0012130)2.35249565
40Leukodystrophy (HP:0002415)2.32893457
41Exertional dyspnea (HP:0002875)2.30534839
42Aplastic anemia (HP:0001915)2.29194578
43Exercise intolerance (HP:0003546)2.27737472
44Microvesicular hepatic steatosis (HP:0001414)2.25637541
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23076394
46Severe combined immunodeficiency (HP:0004430)2.22151936
47Abnormality of midbrain morphology (HP:0002418)2.20624809
48Molar tooth sign on MRI (HP:0002419)2.20624809
49Colon cancer (HP:0003003)2.17488135
50Increased muscle lipid content (HP:0009058)2.17344698
51Respiratory difficulties (HP:0002880)2.15346830
52Respiratory failure (HP:0002878)2.14634065
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13664404
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13664404
55Meckel diverticulum (HP:0002245)2.12488070
56Opisthotonus (HP:0002179)2.11428662
57Abnormality of the anterior horn cell (HP:0006802)2.11286705
58Degeneration of anterior horn cells (HP:0002398)2.11286705
59Congenital, generalized hypertrichosis (HP:0004540)2.11015579
60Hyperglycinemia (HP:0002154)2.10123450
61True hermaphroditism (HP:0010459)2.08171649
62Abnormality of the ileum (HP:0001549)2.07865182
63Pancytopenia (HP:0001876)2.05491971
64Abnormality of serum amino acid levels (HP:0003112)2.04618113
65Lethargy (HP:0001254)2.04587183
66Pancreatic fibrosis (HP:0100732)2.02473757
67Aplasia/hypoplasia of the uterus (HP:0008684)2.01857861
68Thyroiditis (HP:0100646)2.01109316
69Duplicated collecting system (HP:0000081)1.98933578
70Carpal bone hypoplasia (HP:0001498)1.97224968
71Aplasia/Hypoplasia of the uvula (HP:0010293)1.95129454
72Increased IgM level (HP:0003496)1.93965344
73Abnormality of vitamin B metabolism (HP:0004340)1.93565605
74Abnormality of the vitamin B12 metabolism (HP:0004341)1.92732000
75Testicular atrophy (HP:0000029)1.90603028
76Abnormality of the renal collecting system (HP:0004742)1.89978848
77Abnormality of methionine metabolism (HP:0010901)1.89897866
78Hypoproteinemia (HP:0003075)1.89775306
79Abnormality of cochlea (HP:0000375)1.89750409
80T lymphocytopenia (HP:0005403)1.88966894
81Nephronophthisis (HP:0000090)1.86797712
82Type I transferrin isoform profile (HP:0003642)1.86660167
83Pendular nystagmus (HP:0012043)1.84225976
84Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.84039147
85Abnormality of T cells (HP:0002843)1.82430602
86Abnormality of chromosome stability (HP:0003220)1.81969906
87Triphalangeal thumb (HP:0001199)1.81170492
88IgA deficiency (HP:0002720)1.80518530
89Morphological abnormality of the inner ear (HP:0011390)1.76520436
90Abnormality of T cell number (HP:0011839)1.74433851
91Delayed CNS myelination (HP:0002188)1.73573840
92Glycosuria (HP:0003076)1.72923040
93Abnormality of urine glucose concentration (HP:0011016)1.72923040
94Combined immunodeficiency (HP:0005387)1.71999328
95Megaloblastic anemia (HP:0001889)1.70582817
96Cleft eyelid (HP:0000625)1.69115395
97Abnormality of renal resorption (HP:0011038)1.69099110
98Cutaneous melanoma (HP:0012056)1.68726491
99Abnormality of dicarboxylic acid metabolism (HP:0010995)1.68200884
100Dicarboxylic aciduria (HP:0003215)1.68200884

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.25950149
2TSSK64.06887606
3ZAK3.32724360
4EIF2AK33.05605147
5TXK3.01008163
6BUB12.94863467
7MAP4K22.92128963
8NEK12.50020050
9WNK32.31710897
10NME12.31473073
11TLK12.24815217
12STK162.19525207
13EIF2AK12.18522099
14SRPK12.07599886
15TRIM281.94272979
16NUAK11.88234046
17ADRBK21.80706093
18DYRK21.78699972
19WNK41.78091397
20PLK31.64169254
21VRK11.62087305
22VRK21.56675260
23PBK1.49194626
24CDC71.43487747
25CLK11.42332858
26PLK41.30630162
27DAPK21.29166677
28NME21.27266465
29OXSR11.18865739
30ATR1.17181312
31PLK11.16146938
32CCNB11.14868953
33PAK61.10645814
34CSNK1A1L1.06496214
35GRK11.05306809
36TTK1.00758200
37PAK40.98456307
38TAF10.96223532
39CDK190.94904850
40STK40.94048464
41ALK0.93935931
42PAK30.91550168
43CSNK1G30.91185291
44ACVR1B0.90673853
45PASK0.89812515
46FRK0.88808367
47RPS6KA50.87935730
48TIE10.87656083
49IKBKB0.85014990
50MKNK20.83050763
51BRSK20.83017846
52CSNK1G10.76159061
53BCR0.75482369
54BCKDK0.74515669
55STK390.73218480
56MAP3K120.73030594
57DYRK30.72313318
58AKT30.70833781
59AKT20.70712273
60WEE10.70662844
61EIF2AK20.70200754
62PDK20.69821392
63LIMK10.68721080
64CSNK1G20.67145473
65BMPR20.63955709
66BRSK10.63407803
67FGFR10.62676170
68MKNK10.56568710
69ATM0.56240073
70TEC0.54367671
71SGK20.53202121
72DAPK10.52706571
73BMPR1B0.51704846
74PHKG20.50478318
75PHKG10.50478318
76LATS10.50204856
77MAP3K40.48824378
78EPHA30.48677090
79CSNK2A10.48072859
80AURKB0.47784717
81MAP2K60.47367018
82CSNK2A20.46052619
83RPS6KA40.44756929
84INSRR0.44222437
85ITK0.37279000
86PINK10.37194373
87MAP2K70.36980078
88CSNK1A10.36082747
89CHUK0.34475796
90CHEK10.34369459
91PRKCE0.32276816
92PRKCI0.31492382
93RAF10.29997905
94FLT30.29966303
95PLK20.29892161
96SGK4940.28471523
97SGK2230.28471523
98STK30.28102021
99CSNK1E0.27272549
100PRKCG0.25800446

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.76425647
2Protein export_Homo sapiens_hsa030604.34083945
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.23485460
4Mismatch repair_Homo sapiens_hsa034303.02076815
5Homologous recombination_Homo sapiens_hsa034403.01265764
6Oxidative phosphorylation_Homo sapiens_hsa001902.85431714
7RNA polymerase_Homo sapiens_hsa030202.55307996
8Parkinsons disease_Homo sapiens_hsa050122.45990922
9DNA replication_Homo sapiens_hsa030302.30571566
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14168023
11Ribosome_Homo sapiens_hsa030102.06125183
12Nucleotide excision repair_Homo sapiens_hsa034201.86816015
13One carbon pool by folate_Homo sapiens_hsa006701.85689162
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84786655
15Fanconi anemia pathway_Homo sapiens_hsa034601.82471586
16Spliceosome_Homo sapiens_hsa030401.74681299
17RNA transport_Homo sapiens_hsa030131.67865254
18Basal transcription factors_Homo sapiens_hsa030221.65709259
19RNA degradation_Homo sapiens_hsa030181.64417430
20Pyrimidine metabolism_Homo sapiens_hsa002401.62983121
21Non-homologous end-joining_Homo sapiens_hsa034501.62411009
22Primary immunodeficiency_Homo sapiens_hsa053401.62315779
23Huntingtons disease_Homo sapiens_hsa050161.61428814
24Propanoate metabolism_Homo sapiens_hsa006401.59592773
25Caffeine metabolism_Homo sapiens_hsa002321.55907917
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50175282
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48595078
28Alzheimers disease_Homo sapiens_hsa050101.42885799
29Vitamin B6 metabolism_Homo sapiens_hsa007501.41620208
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30137048
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27645953
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.24972585
33Allograft rejection_Homo sapiens_hsa053301.13976350
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13063717
35Base excision repair_Homo sapiens_hsa034101.12662837
36Purine metabolism_Homo sapiens_hsa002301.10686694
37Phototransduction_Homo sapiens_hsa047441.10228128
38Type I diabetes mellitus_Homo sapiens_hsa049401.10002665
39Graft-versus-host disease_Homo sapiens_hsa053321.09354602
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08260291
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95987861
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95391113
43Autoimmune thyroid disease_Homo sapiens_hsa053200.95250513
44Antigen processing and presentation_Homo sapiens_hsa046120.93889664
45Asthma_Homo sapiens_hsa053100.92834720
46Butanoate metabolism_Homo sapiens_hsa006500.90175205
47Systemic lupus erythematosus_Homo sapiens_hsa053220.88864574
48Sulfur metabolism_Homo sapiens_hsa009200.87951407
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82076743
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80690366
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79316822
52Peroxisome_Homo sapiens_hsa041460.78285295
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.77140842
54Nitrogen metabolism_Homo sapiens_hsa009100.74195703
55Pyruvate metabolism_Homo sapiens_hsa006200.72527184
56Rheumatoid arthritis_Homo sapiens_hsa053230.67687932
57Folate biosynthesis_Homo sapiens_hsa007900.67332634
58Steroid biosynthesis_Homo sapiens_hsa001000.65652984
59Sulfur relay system_Homo sapiens_hsa041220.65342270
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63262983
61Metabolic pathways_Homo sapiens_hsa011000.61269984
62mRNA surveillance pathway_Homo sapiens_hsa030150.59529280
63Cardiac muscle contraction_Homo sapiens_hsa042600.58576611
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57828877
65Linoleic acid metabolism_Homo sapiens_hsa005910.57405326
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.57132334
67Glutathione metabolism_Homo sapiens_hsa004800.56103474
68Hematopoietic cell lineage_Homo sapiens_hsa046400.55887883
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52925233
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.52340125
71Collecting duct acid secretion_Homo sapiens_hsa049660.52267762
72Cell cycle_Homo sapiens_hsa041100.51830051
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.50642130
74Regulation of autophagy_Homo sapiens_hsa041400.49241877
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.47914872
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47564250
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45638697
78Fatty acid degradation_Homo sapiens_hsa000710.45049990
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44632350
80Fatty acid biosynthesis_Homo sapiens_hsa000610.44515016
81Fatty acid metabolism_Homo sapiens_hsa012120.44308419
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44257472
83Measles_Homo sapiens_hsa051620.42898196
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42637683
85Tryptophan metabolism_Homo sapiens_hsa003800.40329544
86Fatty acid elongation_Homo sapiens_hsa000620.40180755
87Selenocompound metabolism_Homo sapiens_hsa004500.38270294
88Fat digestion and absorption_Homo sapiens_hsa049750.37827405
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37430370
90Biosynthesis of amino acids_Homo sapiens_hsa012300.36853846
91Ether lipid metabolism_Homo sapiens_hsa005650.36743656
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35608509
93Alcoholism_Homo sapiens_hsa050340.35533620
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.35510399
95Epstein-Barr virus infection_Homo sapiens_hsa051690.35453539
96T cell receptor signaling pathway_Homo sapiens_hsa046600.33742091
97Retinol metabolism_Homo sapiens_hsa008300.32341767
98Chemical carcinogenesis_Homo sapiens_hsa052040.29984551
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29316140
100Mineral absorption_Homo sapiens_hsa049780.29248356

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