

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 5.70355602 |
| 2 | regulation of immunoglobulin secretion (GO:0051023) | 5.44338061 |
| 3 | DNA deamination (GO:0045006) | 5.38211304 |
| 4 | chaperone-mediated protein transport (GO:0072321) | 5.08575010 |
| 5 | proteasome assembly (GO:0043248) | 5.07526180 |
| 6 | regulation of isotype switching to IgG isotypes (GO:0048302) | 4.98218200 |
| 7 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 4.91113793 |
| 8 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.84092693 |
| 9 | regulation of regulatory T cell differentiation (GO:0045589) | 4.59886746 |
| 10 | cytidine metabolic process (GO:0046087) | 4.51837503 |
| 11 | cytidine catabolic process (GO:0006216) | 4.51837503 |
| 12 | cytidine deamination (GO:0009972) | 4.51837503 |
| 13 | positive regulation of interleukin-17 production (GO:0032740) | 4.46239147 |
| 14 | GTP biosynthetic process (GO:0006183) | 4.24701661 |
| 15 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.20056204 |
| 16 | rRNA modification (GO:0000154) | 4.08631428 |
| 17 | transcription from mitochondrial promoter (GO:0006390) | 4.05995319 |
| 18 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.05579061 |
| 19 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.92646436 |
| 20 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.81943958 |
| 21 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.81943958 |
| 22 | NADH dehydrogenase complex assembly (GO:0010257) | 3.81943958 |
| 23 | cullin deneddylation (GO:0010388) | 3.80710543 |
| 24 | UTP biosynthetic process (GO:0006228) | 3.79881539 |
| 25 | ATP synthesis coupled proton transport (GO:0015986) | 3.74730959 |
| 26 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.74730959 |
| 27 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.74306502 |
| 28 | DNA double-strand break processing (GO:0000729) | 3.71818946 |
| 29 | rRNA methylation (GO:0031167) | 3.64775475 |
| 30 | protein deneddylation (GO:0000338) | 3.63613379 |
| 31 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.60453484 |
| 32 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.60453484 |
| 33 | CTP biosynthetic process (GO:0006241) | 3.59095191 |
| 34 | CTP metabolic process (GO:0046036) | 3.59095191 |
| 35 | protein complex biogenesis (GO:0070271) | 3.58978680 |
| 36 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.58902424 |
| 37 | positive regulation of isotype switching (GO:0045830) | 3.58438638 |
| 38 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.56886168 |
| 39 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.56823165 |
| 40 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.55443101 |
| 41 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.51919655 |
| 42 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.48152123 |
| 43 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.44889179 |
| 44 | pyrimidine ribonucleoside biosynthetic process (GO:0046132) | 3.41600095 |
| 45 | negative regulation of ligase activity (GO:0051352) | 3.41396604 |
| 46 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.41396604 |
| 47 | pseudouridine synthesis (GO:0001522) | 3.40733600 |
| 48 | pyrimidine ribonucleoside metabolic process (GO:0046131) | 3.40625153 |
| 49 | UTP metabolic process (GO:0046051) | 3.38178484 |
| 50 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.36201620 |
| 51 | regulation of chronic inflammatory response (GO:0002676) | 3.33273823 |
| 52 | signal peptide processing (GO:0006465) | 3.32730148 |
| 53 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 3.30369907 |
| 54 | ribosome assembly (GO:0042255) | 3.29299282 |
| 55 | intracellular protein transmembrane import (GO:0044743) | 3.26023774 |
| 56 | positive regulation of DNA recombination (GO:0045911) | 3.24362779 |
| 57 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.20097062 |
| 58 | pyrimidine ribonucleotide biosynthetic process (GO:0009220) | 3.19834106 |
| 59 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.16394123 |
| 60 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.15800243 |
| 61 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.14422711 |
| 62 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.11959593 |
| 63 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.11959593 |
| 64 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.11959593 |
| 65 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.10756748 |
| 66 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.09077282 |
| 67 | termination of RNA polymerase III transcription (GO:0006386) | 3.09077282 |
| 68 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.07546580 |
| 69 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.07546580 |
| 70 | tRNA processing (GO:0008033) | 3.05122277 |
| 71 | rRNA processing (GO:0006364) | 3.04028376 |
| 72 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.03396264 |
| 73 | intracellular protein transmembrane transport (GO:0065002) | 3.02314520 |
| 74 | pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208) | 3.02247215 |
| 75 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.01359566 |
| 76 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.01359566 |
| 77 | postreplication repair (GO:0006301) | 3.00672191 |
| 78 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.98979789 |
| 79 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.98384444 |
| 80 | double-strand break repair via homologous recombination (GO:0000724) | 2.97443107 |
| 81 | protein targeting to mitochondrion (GO:0006626) | 2.97285921 |
| 82 | recombinational repair (GO:0000725) | 2.96334565 |
| 83 | positive regulation of ligase activity (GO:0051351) | 2.93711141 |
| 84 | protein-cofactor linkage (GO:0018065) | 2.91541553 |
| 85 | tRNA metabolic process (GO:0006399) | 2.89755019 |
| 86 | rRNA metabolic process (GO:0016072) | 2.89565445 |
| 87 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.89130085 |
| 88 | isotype switching (GO:0045190) | 2.89130085 |
| 89 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.89130085 |
| 90 | spliceosomal complex assembly (GO:0000245) | 2.88920529 |
| 91 | negative regulation of B cell apoptotic process (GO:0002903) | 2.88446052 |
| 92 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.88424510 |
| 93 | nucleoside diphosphate phosphorylation (GO:0006165) | 2.86895950 |
| 94 | telomere maintenance via recombination (GO:0000722) | 2.86800118 |
| 95 | pyrimidine ribonucleotide metabolic process (GO:0009218) | 2.84701869 |
| 96 | peptidyl-histidine modification (GO:0018202) | 2.81334145 |
| 97 | positive regulation of defense response to virus by host (GO:0002230) | 2.80494856 |
| 98 | amino acid activation (GO:0043038) | 2.80395719 |
| 99 | tRNA aminoacylation (GO:0043039) | 2.80395719 |
| 100 | tRNA aminoacylation for protein translation (GO:0006418) | 2.80231685 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 5.23461904 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.16244225 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.58895189 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.05522793 |
| 5 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.58956841 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.49440161 |
| 7 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 3.38315899 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.28235055 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.14687388 |
| 10 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.11943638 |
| 11 | VDR_23849224_ChIP-Seq_CD4+_Human | 3.05044548 |
| 12 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.74218604 |
| 13 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.69602803 |
| 14 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.67554256 |
| 15 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.54436129 |
| 16 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.53776630 |
| 17 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.52385858 |
| 18 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.44554028 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.39858474 |
| 20 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.28718009 |
| 21 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.21243247 |
| 22 | VDR_22108803_ChIP-Seq_LS180_Human | 2.14262029 |
| 23 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.13026981 |
| 24 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.07790601 |
| 25 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.05531943 |
| 26 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.05145163 |
| 27 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.00330797 |
| 28 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.92332688 |
| 29 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.91675629 |
| 30 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.83648124 |
| 31 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.83401016 |
| 32 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.80134812 |
| 33 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.78487276 |
| 34 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.77950788 |
| 35 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.74931097 |
| 36 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.68743137 |
| 37 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.66093568 |
| 38 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.65487333 |
| 39 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.65089554 |
| 40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.61834931 |
| 41 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.58279829 |
| 42 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.57593712 |
| 43 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.53333934 |
| 44 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.49940296 |
| 45 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.47768351 |
| 46 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.47572002 |
| 47 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.46353132 |
| 48 | EWS_26573619_Chip-Seq_HEK293_Human | 1.45503098 |
| 49 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.43590053 |
| 50 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.41650395 |
| 51 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.40389784 |
| 52 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.40310383 |
| 53 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.33725269 |
| 54 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.30118060 |
| 55 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.28898641 |
| 56 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.27336993 |
| 57 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.24720465 |
| 58 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.20970931 |
| 59 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.17522171 |
| 60 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.15400647 |
| 61 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.11904463 |
| 62 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.10930690 |
| 63 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.09787315 |
| 64 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.09409899 |
| 65 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08746479 |
| 66 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.06366355 |
| 67 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.06003316 |
| 68 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.05276646 |
| 69 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.04562294 |
| 70 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.01141471 |
| 71 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.98585515 |
| 72 | FUS_26573619_Chip-Seq_HEK293_Human | 0.98095083 |
| 73 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.95834012 |
| 74 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.95478470 |
| 75 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.93599205 |
| 76 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.93325909 |
| 77 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.93050754 |
| 78 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.90698801 |
| 79 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.90641550 |
| 80 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.89644928 |
| 81 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.89562214 |
| 82 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.88705405 |
| 83 | GATA3_26560356_Chip-Seq_TH2_Human | 0.87227478 |
| 84 | P300_19829295_ChIP-Seq_ESCs_Human | 0.84679516 |
| 85 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.84017831 |
| 86 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.83676226 |
| 87 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.83221339 |
| 88 | AR_20517297_ChIP-Seq_VCAP_Human | 0.83144991 |
| 89 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.82642845 |
| 90 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.80683930 |
| 91 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.80683930 |
| 92 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.79657608 |
| 93 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.78453567 |
| 94 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.76617708 |
| 95 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.76442628 |
| 96 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.76232703 |
| 97 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.76166545 |
| 98 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.75323665 |
| 99 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.75323665 |
| 100 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.75236230 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 3.21307951 |
| 2 | MP0008058_abnormal_DNA_repair | 2.95419535 |
| 3 | MP0005671_abnormal_response_to | 2.93135577 |
| 4 | MP0008057_abnormal_DNA_replication | 2.83860208 |
| 5 | MP0008877_abnormal_DNA_methylation | 2.83692386 |
| 6 | MP0010094_abnormal_chromosome_stability | 2.66818758 |
| 7 | MP0006292_abnormal_olfactory_placode | 2.64612625 |
| 8 | MP0008872_abnormal_physiological_respon | 2.56371832 |
| 9 | MP0002163_abnormal_gland_morphology | 2.54200870 |
| 10 | MP0004147_increased_porphyrin_level | 2.51034171 |
| 11 | MP0001873_stomach_inflammation | 2.28586037 |
| 12 | MP0001853_heart_inflammation | 2.24605933 |
| 13 | MP0003718_maternal_effect | 2.16868110 |
| 14 | MP0002837_dystrophic_cardiac_calcinosis | 2.07495233 |
| 15 | MP0008875_abnormal_xenobiotic_pharmacok | 2.02708476 |
| 16 | MP0003186_abnormal_redox_activity | 1.98639282 |
| 17 | MP0004957_abnormal_blastocyst_morpholog | 1.97806558 |
| 18 | MP0003693_abnormal_embryo_hatching | 1.95287997 |
| 19 | MP0003786_premature_aging | 1.93132479 |
| 20 | MP0003806_abnormal_nucleotide_metabolis | 1.92720111 |
| 21 | MP0005387_immune_system_phenotype | 1.72131376 |
| 22 | MP0001790_abnormal_immune_system | 1.72131376 |
| 23 | MP0009785_altered_susceptibility_to | 1.70545704 |
| 24 | MP0002148_abnormal_hypersensitivity_rea | 1.70000048 |
| 25 | MP0000372_irregular_coat_pigmentation | 1.69966949 |
| 26 | MP0002736_abnormal_nociception_after | 1.68499476 |
| 27 | MP0005379_endocrine/exocrine_gland_phen | 1.66931210 |
| 28 | MP0009333_abnormal_splenocyte_physiolog | 1.66356567 |
| 29 | MP0002938_white_spotting | 1.64525790 |
| 30 | MP0000465_gastrointestinal_hemorrhage | 1.64066441 |
| 31 | MP0002138_abnormal_hepatobiliary_system | 1.63213777 |
| 32 | MP0004782_abnormal_surfactant_physiolog | 1.60822502 |
| 33 | MP0005645_abnormal_hypothalamus_physiol | 1.48772241 |
| 34 | MP0003195_calcinosis | 1.43947544 |
| 35 | MP0003878_abnormal_ear_physiology | 1.42875602 |
| 36 | MP0005377_hearing/vestibular/ear_phenot | 1.42875602 |
| 37 | MP0006072_abnormal_retinal_apoptosis | 1.41712125 |
| 38 | MP0006036_abnormal_mitochondrial_physio | 1.37884562 |
| 39 | MP0001984_abnormal_olfaction | 1.37744015 |
| 40 | MP0001968_abnormal_touch/_nociception | 1.33047139 |
| 41 | MP0004742_abnormal_vestibular_system | 1.30839727 |
| 42 | MP0000685_abnormal_immune_system | 1.30388930 |
| 43 | MP0003763_abnormal_thymus_physiology | 1.29948166 |
| 44 | MP0003221_abnormal_cardiomyocyte_apopto | 1.24390880 |
| 45 | MP0002876_abnormal_thyroid_physiology | 1.22366950 |
| 46 | MP0003077_abnormal_cell_cycle | 1.21217156 |
| 47 | MP0005084_abnormal_gallbladder_morpholo | 1.20386813 |
| 48 | MP0003300_gastrointestinal_ulcer | 1.19499466 |
| 49 | MP0008932_abnormal_embryonic_tissue | 1.19012531 |
| 50 | MP0001800_abnormal_humoral_immune | 1.18522826 |
| 51 | MP0003111_abnormal_nucleus_morphology | 1.16991371 |
| 52 | MP0001986_abnormal_taste_sensitivity | 1.16594442 |
| 53 | MP0002405_respiratory_system_inflammati | 1.14442963 |
| 54 | MP0004142_abnormal_muscle_tone | 1.12016475 |
| 55 | MP0001919_abnormal_reproductive_system | 1.11512467 |
| 56 | MP0002277_abnormal_respiratory_mucosa | 1.10027006 |
| 57 | MP0005253_abnormal_eye_physiology | 1.09483380 |
| 58 | MP0005187_abnormal_penis_morphology | 1.07932356 |
| 59 | MP0009697_abnormal_copulation | 1.07139305 |
| 60 | MP0002234_abnormal_pharynx_morphology | 1.06566375 |
| 61 | MP0006035_abnormal_mitochondrial_morpho | 1.03470631 |
| 62 | MP0005000_abnormal_immune_tolerance | 1.03224227 |
| 63 | MP0002102_abnormal_ear_morphology | 1.03132591 |
| 64 | MP0001485_abnormal_pinna_reflex | 1.01464564 |
| 65 | MP0001529_abnormal_vocalization | 1.01351120 |
| 66 | MP0005389_reproductive_system_phenotype | 0.98859651 |
| 67 | MP0008873_increased_physiological_sensi | 0.97943790 |
| 68 | MP0008789_abnormal_olfactory_epithelium | 0.96914106 |
| 69 | MP0004145_abnormal_muscle_electrophysio | 0.96189294 |
| 70 | MP0003567_abnormal_fetal_cardiomyocyte | 0.94380523 |
| 71 | MP0004215_abnormal_myocardial_fiber | 0.93965305 |
| 72 | MP0000703_abnormal_thymus_morphology | 0.92260196 |
| 73 | MP0002693_abnormal_pancreas_physiology | 0.92243651 |
| 74 | MP0000689_abnormal_spleen_morphology | 0.92087408 |
| 75 | MP0005551_abnormal_eye_electrophysiolog | 0.90340247 |
| 76 | MP0005410_abnormal_fertilization | 0.90001990 |
| 77 | MP0005636_abnormal_mineral_homeostasis | 0.89316044 |
| 78 | MP0002254_reproductive_system_inflammat | 0.87613537 |
| 79 | MP0001188_hyperpigmentation | 0.87005610 |
| 80 | MP0001348_abnormal_lacrimal_gland | 0.86262183 |
| 81 | MP0005167_abnormal_blood-brain_barrier | 0.84781880 |
| 82 | MP0010307_abnormal_tumor_latency | 0.83060708 |
| 83 | MP0002723_abnormal_immune_serum | 0.81162915 |
| 84 | MP0010155_abnormal_intestine_physiology | 0.80970912 |
| 85 | MP0008995_early_reproductive_senescence | 0.79574339 |
| 86 | MP0003011_delayed_dark_adaptation | 0.79205959 |
| 87 | MP0002210_abnormal_sex_determination | 0.76831251 |
| 88 | MP0004043_abnormal_pH_regulation | 0.76487003 |
| 89 | MP0002722_abnormal_immune_system | 0.74255530 |
| 90 | MP0002420_abnormal_adaptive_immunity | 0.70783337 |
| 91 | MP0003936_abnormal_reproductive_system | 0.69553989 |
| 92 | MP0002160_abnormal_reproductive_system | 0.68010472 |
| 93 | MP0002398_abnormal_bone_marrow | 0.67123397 |
| 94 | MP0001845_abnormal_inflammatory_respons | 0.66256838 |
| 95 | MP0000049_abnormal_middle_ear | 0.64763880 |
| 96 | MP0001819_abnormal_immune_cell | 0.64621977 |
| 97 | MP0005395_other_phenotype | 0.63452678 |
| 98 | MP0009765_abnormal_xenobiotic_induced | 0.62900084 |
| 99 | MP0005365_abnormal_bile_salt | 0.62884929 |
| 100 | MP0001929_abnormal_gametogenesis | 0.62021093 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.56650273 |
| 2 | Abnormality of the labia minora (HP:0012880) | 4.21960992 |
| 3 | Acute encephalopathy (HP:0006846) | 4.07695746 |
| 4 | Increased hepatocellular lipid droplets (HP:0006565) | 4.02213259 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.01088194 |
| 6 | Mitochondrial inheritance (HP:0001427) | 3.99396862 |
| 7 | Increased CSF lactate (HP:0002490) | 3.96982249 |
| 8 | Lipid accumulation in hepatocytes (HP:0006561) | 3.82671327 |
| 9 | Progressive macrocephaly (HP:0004481) | 3.67466050 |
| 10 | 3-Methylglutaconic aciduria (HP:0003535) | 3.32342811 |
| 11 | Methylmalonic acidemia (HP:0002912) | 3.27940338 |
| 12 | Hypoplasia of the pons (HP:0012110) | 3.22068763 |
| 13 | Abnormality of the pons (HP:0007361) | 3.21635323 |
| 14 | Increased serum pyruvate (HP:0003542) | 3.14888676 |
| 15 | IgG deficiency (HP:0004315) | 3.08301268 |
| 16 | Hepatocellular necrosis (HP:0001404) | 3.04973834 |
| 17 | Chromsome breakage (HP:0040012) | 3.00090005 |
| 18 | Methylmalonic aciduria (HP:0012120) | 2.99333902 |
| 19 | Increased serum lactate (HP:0002151) | 2.95269758 |
| 20 | Abnormal number of erythroid precursors (HP:0012131) | 2.89630045 |
| 21 | Cerebral edema (HP:0002181) | 2.88533914 |
| 22 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.86848709 |
| 23 | Abnormality of alanine metabolism (HP:0010916) | 2.86848709 |
| 24 | Hyperalaninemia (HP:0003348) | 2.86848709 |
| 25 | Stomatitis (HP:0010280) | 2.83223800 |
| 26 | Hepatic necrosis (HP:0002605) | 2.82155726 |
| 27 | Back pain (HP:0003418) | 2.79443112 |
| 28 | Pancreatic cysts (HP:0001737) | 2.76414013 |
| 29 | Renal Fanconi syndrome (HP:0001994) | 2.68542875 |
| 30 | Constricted visual fields (HP:0001133) | 2.63246472 |
| 31 | Abnormality of glycolysis (HP:0004366) | 2.62148107 |
| 32 | Birth length less than 3rd percentile (HP:0003561) | 2.57632912 |
| 33 | Cystic liver disease (HP:0006706) | 2.55604036 |
| 34 | Increased intramyocellular lipid droplets (HP:0012240) | 2.53724186 |
| 35 | Lactic acidosis (HP:0003128) | 2.49895076 |
| 36 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.46124690 |
| 37 | Optic disc pallor (HP:0000543) | 2.44063391 |
| 38 | Oral leukoplakia (HP:0002745) | 2.43831109 |
| 39 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.35249565 |
| 40 | Leukodystrophy (HP:0002415) | 2.32893457 |
| 41 | Exertional dyspnea (HP:0002875) | 2.30534839 |
| 42 | Aplastic anemia (HP:0001915) | 2.29194578 |
| 43 | Exercise intolerance (HP:0003546) | 2.27737472 |
| 44 | Microvesicular hepatic steatosis (HP:0001414) | 2.25637541 |
| 45 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.23076394 |
| 46 | Severe combined immunodeficiency (HP:0004430) | 2.22151936 |
| 47 | Abnormality of midbrain morphology (HP:0002418) | 2.20624809 |
| 48 | Molar tooth sign on MRI (HP:0002419) | 2.20624809 |
| 49 | Colon cancer (HP:0003003) | 2.17488135 |
| 50 | Increased muscle lipid content (HP:0009058) | 2.17344698 |
| 51 | Respiratory difficulties (HP:0002880) | 2.15346830 |
| 52 | Respiratory failure (HP:0002878) | 2.14634065 |
| 53 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.13664404 |
| 54 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.13664404 |
| 55 | Meckel diverticulum (HP:0002245) | 2.12488070 |
| 56 | Opisthotonus (HP:0002179) | 2.11428662 |
| 57 | Abnormality of the anterior horn cell (HP:0006802) | 2.11286705 |
| 58 | Degeneration of anterior horn cells (HP:0002398) | 2.11286705 |
| 59 | Congenital, generalized hypertrichosis (HP:0004540) | 2.11015579 |
| 60 | Hyperglycinemia (HP:0002154) | 2.10123450 |
| 61 | True hermaphroditism (HP:0010459) | 2.08171649 |
| 62 | Abnormality of the ileum (HP:0001549) | 2.07865182 |
| 63 | Pancytopenia (HP:0001876) | 2.05491971 |
| 64 | Abnormality of serum amino acid levels (HP:0003112) | 2.04618113 |
| 65 | Lethargy (HP:0001254) | 2.04587183 |
| 66 | Pancreatic fibrosis (HP:0100732) | 2.02473757 |
| 67 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.01857861 |
| 68 | Thyroiditis (HP:0100646) | 2.01109316 |
| 69 | Duplicated collecting system (HP:0000081) | 1.98933578 |
| 70 | Carpal bone hypoplasia (HP:0001498) | 1.97224968 |
| 71 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.95129454 |
| 72 | Increased IgM level (HP:0003496) | 1.93965344 |
| 73 | Abnormality of vitamin B metabolism (HP:0004340) | 1.93565605 |
| 74 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.92732000 |
| 75 | Testicular atrophy (HP:0000029) | 1.90603028 |
| 76 | Abnormality of the renal collecting system (HP:0004742) | 1.89978848 |
| 77 | Abnormality of methionine metabolism (HP:0010901) | 1.89897866 |
| 78 | Hypoproteinemia (HP:0003075) | 1.89775306 |
| 79 | Abnormality of cochlea (HP:0000375) | 1.89750409 |
| 80 | T lymphocytopenia (HP:0005403) | 1.88966894 |
| 81 | Nephronophthisis (HP:0000090) | 1.86797712 |
| 82 | Type I transferrin isoform profile (HP:0003642) | 1.86660167 |
| 83 | Pendular nystagmus (HP:0012043) | 1.84225976 |
| 84 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.84039147 |
| 85 | Abnormality of T cells (HP:0002843) | 1.82430602 |
| 86 | Abnormality of chromosome stability (HP:0003220) | 1.81969906 |
| 87 | Triphalangeal thumb (HP:0001199) | 1.81170492 |
| 88 | IgA deficiency (HP:0002720) | 1.80518530 |
| 89 | Morphological abnormality of the inner ear (HP:0011390) | 1.76520436 |
| 90 | Abnormality of T cell number (HP:0011839) | 1.74433851 |
| 91 | Delayed CNS myelination (HP:0002188) | 1.73573840 |
| 92 | Glycosuria (HP:0003076) | 1.72923040 |
| 93 | Abnormality of urine glucose concentration (HP:0011016) | 1.72923040 |
| 94 | Combined immunodeficiency (HP:0005387) | 1.71999328 |
| 95 | Megaloblastic anemia (HP:0001889) | 1.70582817 |
| 96 | Cleft eyelid (HP:0000625) | 1.69115395 |
| 97 | Abnormality of renal resorption (HP:0011038) | 1.69099110 |
| 98 | Cutaneous melanoma (HP:0012056) | 1.68726491 |
| 99 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.68200884 |
| 100 | Dicarboxylic aciduria (HP:0003215) | 1.68200884 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MST4 | 4.25950149 |
| 2 | TSSK6 | 4.06887606 |
| 3 | ZAK | 3.32724360 |
| 4 | EIF2AK3 | 3.05605147 |
| 5 | TXK | 3.01008163 |
| 6 | BUB1 | 2.94863467 |
| 7 | MAP4K2 | 2.92128963 |
| 8 | NEK1 | 2.50020050 |
| 9 | WNK3 | 2.31710897 |
| 10 | NME1 | 2.31473073 |
| 11 | TLK1 | 2.24815217 |
| 12 | STK16 | 2.19525207 |
| 13 | EIF2AK1 | 2.18522099 |
| 14 | SRPK1 | 2.07599886 |
| 15 | TRIM28 | 1.94272979 |
| 16 | NUAK1 | 1.88234046 |
| 17 | ADRBK2 | 1.80706093 |
| 18 | DYRK2 | 1.78699972 |
| 19 | WNK4 | 1.78091397 |
| 20 | PLK3 | 1.64169254 |
| 21 | VRK1 | 1.62087305 |
| 22 | VRK2 | 1.56675260 |
| 23 | PBK | 1.49194626 |
| 24 | CDC7 | 1.43487747 |
| 25 | CLK1 | 1.42332858 |
| 26 | PLK4 | 1.30630162 |
| 27 | DAPK2 | 1.29166677 |
| 28 | NME2 | 1.27266465 |
| 29 | OXSR1 | 1.18865739 |
| 30 | ATR | 1.17181312 |
| 31 | PLK1 | 1.16146938 |
| 32 | CCNB1 | 1.14868953 |
| 33 | PAK6 | 1.10645814 |
| 34 | CSNK1A1L | 1.06496214 |
| 35 | GRK1 | 1.05306809 |
| 36 | TTK | 1.00758200 |
| 37 | PAK4 | 0.98456307 |
| 38 | TAF1 | 0.96223532 |
| 39 | CDK19 | 0.94904850 |
| 40 | STK4 | 0.94048464 |
| 41 | ALK | 0.93935931 |
| 42 | PAK3 | 0.91550168 |
| 43 | CSNK1G3 | 0.91185291 |
| 44 | ACVR1B | 0.90673853 |
| 45 | PASK | 0.89812515 |
| 46 | FRK | 0.88808367 |
| 47 | RPS6KA5 | 0.87935730 |
| 48 | TIE1 | 0.87656083 |
| 49 | IKBKB | 0.85014990 |
| 50 | MKNK2 | 0.83050763 |
| 51 | BRSK2 | 0.83017846 |
| 52 | CSNK1G1 | 0.76159061 |
| 53 | BCR | 0.75482369 |
| 54 | BCKDK | 0.74515669 |
| 55 | STK39 | 0.73218480 |
| 56 | MAP3K12 | 0.73030594 |
| 57 | DYRK3 | 0.72313318 |
| 58 | AKT3 | 0.70833781 |
| 59 | AKT2 | 0.70712273 |
| 60 | WEE1 | 0.70662844 |
| 61 | EIF2AK2 | 0.70200754 |
| 62 | PDK2 | 0.69821392 |
| 63 | LIMK1 | 0.68721080 |
| 64 | CSNK1G2 | 0.67145473 |
| 65 | BMPR2 | 0.63955709 |
| 66 | BRSK1 | 0.63407803 |
| 67 | FGFR1 | 0.62676170 |
| 68 | MKNK1 | 0.56568710 |
| 69 | ATM | 0.56240073 |
| 70 | TEC | 0.54367671 |
| 71 | SGK2 | 0.53202121 |
| 72 | DAPK1 | 0.52706571 |
| 73 | BMPR1B | 0.51704846 |
| 74 | PHKG2 | 0.50478318 |
| 75 | PHKG1 | 0.50478318 |
| 76 | LATS1 | 0.50204856 |
| 77 | MAP3K4 | 0.48824378 |
| 78 | EPHA3 | 0.48677090 |
| 79 | CSNK2A1 | 0.48072859 |
| 80 | AURKB | 0.47784717 |
| 81 | MAP2K6 | 0.47367018 |
| 82 | CSNK2A2 | 0.46052619 |
| 83 | RPS6KA4 | 0.44756929 |
| 84 | INSRR | 0.44222437 |
| 85 | ITK | 0.37279000 |
| 86 | PINK1 | 0.37194373 |
| 87 | MAP2K7 | 0.36980078 |
| 88 | CSNK1A1 | 0.36082747 |
| 89 | CHUK | 0.34475796 |
| 90 | CHEK1 | 0.34369459 |
| 91 | PRKCE | 0.32276816 |
| 92 | PRKCI | 0.31492382 |
| 93 | RAF1 | 0.29997905 |
| 94 | FLT3 | 0.29966303 |
| 95 | PLK2 | 0.29892161 |
| 96 | SGK494 | 0.28471523 |
| 97 | SGK223 | 0.28471523 |
| 98 | STK3 | 0.28102021 |
| 99 | CSNK1E | 0.27272549 |
| 100 | PRKCG | 0.25800446 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.76425647 |
| 2 | Protein export_Homo sapiens_hsa03060 | 4.34083945 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.23485460 |
| 4 | Mismatch repair_Homo sapiens_hsa03430 | 3.02076815 |
| 5 | Homologous recombination_Homo sapiens_hsa03440 | 3.01265764 |
| 6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.85431714 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.55307996 |
| 8 | Parkinsons disease_Homo sapiens_hsa05012 | 2.45990922 |
| 9 | DNA replication_Homo sapiens_hsa03030 | 2.30571566 |
| 10 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.14168023 |
| 11 | Ribosome_Homo sapiens_hsa03010 | 2.06125183 |
| 12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.86816015 |
| 13 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.85689162 |
| 14 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.84786655 |
| 15 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.82471586 |
| 16 | Spliceosome_Homo sapiens_hsa03040 | 1.74681299 |
| 17 | RNA transport_Homo sapiens_hsa03013 | 1.67865254 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.65709259 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 1.64417430 |
| 20 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.62983121 |
| 21 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.62411009 |
| 22 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.62315779 |
| 23 | Huntingtons disease_Homo sapiens_hsa05016 | 1.61428814 |
| 24 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.59592773 |
| 25 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.55907917 |
| 26 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.50175282 |
| 27 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.48595078 |
| 28 | Alzheimers disease_Homo sapiens_hsa05010 | 1.42885799 |
| 29 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.41620208 |
| 30 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.30137048 |
| 31 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.27645953 |
| 32 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.24972585 |
| 33 | Allograft rejection_Homo sapiens_hsa05330 | 1.13976350 |
| 34 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.13063717 |
| 35 | Base excision repair_Homo sapiens_hsa03410 | 1.12662837 |
| 36 | Purine metabolism_Homo sapiens_hsa00230 | 1.10686694 |
| 37 | Phototransduction_Homo sapiens_hsa04744 | 1.10228128 |
| 38 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.10002665 |
| 39 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.09354602 |
| 40 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.08260291 |
| 41 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.95987861 |
| 42 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.95391113 |
| 43 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.95250513 |
| 44 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.93889664 |
| 45 | Asthma_Homo sapiens_hsa05310 | 0.92834720 |
| 46 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.90175205 |
| 47 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.88864574 |
| 48 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.87951407 |
| 49 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.82076743 |
| 50 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.80690366 |
| 51 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.79316822 |
| 52 | Peroxisome_Homo sapiens_hsa04146 | 0.78285295 |
| 53 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.77140842 |
| 54 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.74195703 |
| 55 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.72527184 |
| 56 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.67687932 |
| 57 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.67332634 |
| 58 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.65652984 |
| 59 | Sulfur relay system_Homo sapiens_hsa04122 | 0.65342270 |
| 60 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.63262983 |
| 61 | Metabolic pathways_Homo sapiens_hsa01100 | 0.61269984 |
| 62 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.59529280 |
| 63 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.58576611 |
| 64 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.57828877 |
| 65 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.57405326 |
| 66 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.57132334 |
| 67 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.56103474 |
| 68 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.55887883 |
| 69 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.52925233 |
| 70 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.52340125 |
| 71 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.52267762 |
| 72 | Cell cycle_Homo sapiens_hsa04110 | 0.51830051 |
| 73 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.50642130 |
| 74 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.49241877 |
| 75 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.47914872 |
| 76 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.47564250 |
| 77 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.45638697 |
| 78 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.45049990 |
| 79 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.44632350 |
| 80 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.44515016 |
| 81 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.44308419 |
| 82 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.44257472 |
| 83 | Measles_Homo sapiens_hsa05162 | 0.42898196 |
| 84 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.42637683 |
| 85 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.40329544 |
| 86 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.40180755 |
| 87 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.38270294 |
| 88 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.37827405 |
| 89 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.37430370 |
| 90 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.36853846 |
| 91 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.36743656 |
| 92 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.35608509 |
| 93 | Alcoholism_Homo sapiens_hsa05034 | 0.35533620 |
| 94 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.35510399 |
| 95 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.35453539 |
| 96 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.33742091 |
| 97 | Retinol metabolism_Homo sapiens_hsa00830 | 0.32341767 |
| 98 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.29984551 |
| 99 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.29316140 |
| 100 | Mineral absorption_Homo sapiens_hsa04978 | 0.29248356 |

