HSPD1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of immunoglobulin secretion (GO:0051023)9.92030567
2positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)9.59259162
3regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)8.30843766
4regulation of regulatory T cell differentiation (GO:0045589)6.15905706
5negative regulation of B cell apoptotic process (GO:0002903)6.08429857
6regulation of isotype switching to IgG isotypes (GO:0048302)5.97904213
7positive regulation of interleukin-17 production (GO:0032740)5.93952492
8tachykinin receptor signaling pathway (GO:0007217)5.34116958
9somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)5.30465199
10somatic diversification of immunoglobulins involved in immune response (GO:0002208)5.30465199
11isotype switching (GO:0045190)5.30465199
12positive regulation of isotype switching (GO:0045830)4.96947880
13positive regulation of DNA recombination (GO:0045911)4.79199995
14rRNA modification (GO:0000154)4.76568441
15positive regulation of uterine smooth muscle contraction (GO:0070474)4.73135043
16DNA deamination (GO:0045006)4.55143201
17positive regulation of T cell migration (GO:2000406)4.39414013
18cullin deneddylation (GO:0010388)4.39250205
19rRNA methylation (GO:0031167)4.22980384
20ribosome biogenesis (GO:0042254)4.22940616
21regulation of B cell apoptotic process (GO:0002902)4.20212354
22positive regulation of activated T cell proliferation (GO:0042104)4.06896529
23proteasome assembly (GO:0043248)4.05682705
24positive regulation of protein homodimerization activity (GO:0090073)4.05004547
25protein deneddylation (GO:0000338)4.02561837
26regulation of mitotic spindle checkpoint (GO:1903504)3.89818444
27regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.89818444
28synapsis (GO:0007129)3.82732164
29somatic recombination of immunoglobulin gene segments (GO:0016447)3.71140722
30regulation of T cell migration (GO:2000404)3.68088578
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.63863128
32interferon-gamma production (GO:0032609)3.58094430
33GTP biosynthetic process (GO:0006183)3.57784545
34somatic diversification of immunoglobulins (GO:0016445)3.57387984
35positive regulation of lymphocyte migration (GO:2000403)3.54356824
36regulation of uterine smooth muscle contraction (GO:0070472)3.50877874
37chaperone-mediated protein transport (GO:0072321)3.50784799
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.45395736
39ribonucleoprotein complex biogenesis (GO:0022613)3.40701032
40regulation of immunoglobulin production (GO:0002637)3.39035850
41positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.38635584
42regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.25668680
43regulation of memory T cell differentiation (GO:0043380)3.24017018
44regulation of cellular amino acid metabolic process (GO:0006521)3.23796223
45negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.22183704
46negative regulation of ligase activity (GO:0051352)3.22183704
47pseudouridine synthesis (GO:0001522)3.21675886
48detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.18295168
49positive regulation of triglyceride biosynthetic process (GO:0010867)3.17012292
50regulation of interleukin-17 production (GO:0032660)3.14644241
51energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12846667
52ATP synthesis coupled proton transport (GO:0015986)3.12846667
53protein targeting to mitochondrion (GO:0006626)3.12653365
54positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.11175129
55somatic hypermutation of immunoglobulin genes (GO:0016446)3.08647459
56somatic diversification of immune receptors via somatic mutation (GO:0002566)3.08647459
57tolerance induction (GO:0002507)3.06979992
58positive regulation of immunoglobulin mediated immune response (GO:0002891)3.05967744
59positive regulation of B cell mediated immunity (GO:0002714)3.05967744
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.05757925
61regulation of mitochondrial translation (GO:0070129)3.05059064
62signal peptide processing (GO:0006465)3.04524644
63B cell activation involved in immune response (GO:0002312)3.04360241
64positive regulation of endothelial cell apoptotic process (GO:2000353)3.03027039
65ribosomal small subunit assembly (GO:0000028)3.00654294
66positive regulation of defense response to virus by host (GO:0002230)2.99561395
67signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97106958
68signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97106958
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97106958
70intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.96750575
71signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.96750575
72pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.96486409
73UTP biosynthetic process (GO:0006228)2.96385693
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94749283
75peptidyl-histidine modification (GO:0018202)2.93852057
76rRNA processing (GO:0006364)2.90990716
77regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.90530524
78regulation of isotype switching (GO:0045191)2.86173346
79mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.86112100
80rRNA metabolic process (GO:0016072)2.84873191
81establishment of protein localization to mitochondrion (GO:0072655)2.83710067
82signal transduction involved in DNA integrity checkpoint (GO:0072401)2.82673352
83signal transduction involved in DNA damage checkpoint (GO:0072422)2.82673352
84regulation of tyrosine phosphorylation of STAT protein (GO:0042509)2.79948416
85signal transduction involved in cell cycle checkpoint (GO:0072395)2.79871830
86cellular component biogenesis (GO:0044085)2.79555809
87pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.78379144
88ribosomal large subunit biogenesis (GO:0042273)2.77652948
89protein localization to mitochondrion (GO:0070585)2.77584617
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.76538015
91transcription elongation from RNA polymerase III promoter (GO:0006385)2.73703146
92termination of RNA polymerase III transcription (GO:0006386)2.73703146
93pyrimidine nucleotide biosynthetic process (GO:0006221)2.72533231
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.71601968
95nucleobase biosynthetic process (GO:0046112)2.69985454
96DNA replication-dependent nucleosome organization (GO:0034723)2.69236109
97DNA replication-dependent nucleosome assembly (GO:0006335)2.69236109
98inner mitochondrial membrane organization (GO:0007007)2.68917372
99CTP metabolic process (GO:0046036)2.68771462
100CTP biosynthetic process (GO:0006241)2.68771462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.93372395
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.76684838
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.52182101
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.08607600
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.18922526
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.16168615
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.11422978
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.95827155
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.70373977
10VDR_23849224_ChIP-Seq_CD4+_Human2.68498484
11VDR_22108803_ChIP-Seq_LS180_Human2.65510250
12ELK1_19687146_ChIP-ChIP_HELA_Human2.59568000
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36723046
14FOXP3_21729870_ChIP-Seq_TREG_Human2.35728270
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26486963
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24262602
17E2F7_22180533_ChIP-Seq_HELA_Human2.23345993
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20300024
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03581002
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02445759
21EWS_26573619_Chip-Seq_HEK293_Human1.98957035
22MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96474234
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93415696
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90206674
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89358961
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.87254285
27MYC_18940864_ChIP-ChIP_HL60_Human1.81245027
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.80324579
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77190677
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.71655101
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.71279630
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70435702
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62725660
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62398835
35TTF2_22483619_ChIP-Seq_HELA_Human1.61742268
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.59947435
37DCP1A_22483619_ChIP-Seq_HELA_Human1.59752315
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57544593
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.56610303
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51580291
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50184726
42ZNF274_21170338_ChIP-Seq_K562_Hela1.45708838
43GATA3_26560356_Chip-Seq_TH2_Human1.42678041
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36074599
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35886295
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33872243
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33720327
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32997081
49TP53_22573176_ChIP-Seq_HFKS_Human1.32029544
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31350600
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30438583
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30021119
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28857369
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.27292635
55DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27144407
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20596894
57AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19563225
58ERG_20517297_ChIP-Seq_VCAP_Human1.19030008
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18597235
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17324193
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15527229
62GATA6_21074721_ChIP-Seq_CACO-2_Human1.12313916
63GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.12165448
64MYB_26560356_Chip-Seq_TH2_Human1.11924826
65NCOR_22424771_ChIP-Seq_293T_Human1.10871749
66GATA3_27048872_Chip-Seq_THYMUS_Human1.08751408
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08168208
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.05172076
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05166822
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05145623
71OCT4_18555785_Chip-Seq_ESCs_Mouse1.04887312
72STAT3_18555785_Chip-Seq_ESCs_Mouse1.04429524
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03914614
74AR_21909140_ChIP-Seq_LNCAP_Human1.03397164
75PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02601263
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01506228
77PHF8_20622853_ChIP-Seq_HELA_Human1.01340338
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00536133
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00132307
80EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99889011
81FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98898692
82FOXA1_25329375_ChIP-Seq_VCAP_Human0.98898692
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98391714
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97960953
85P300_18555785_Chip-Seq_ESCs_Mouse0.97835637
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.95253135
87NANOG_19829295_ChIP-Seq_ESCs_Human0.94110813
88SOX2_19829295_ChIP-Seq_ESCs_Human0.94110813
89ELK1_22589737_ChIP-Seq_MCF10A_Human0.93043286
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93041627
91CTCF_18555785_Chip-Seq_ESCs_Mouse0.92659710
92CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92156380
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92109611
94BCAT_22108803_ChIP-Seq_LS180_Human0.91557610
95CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91554033
96RBPJ_21746931_ChIP-Seq_IB4_Human0.91191756
97STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89973301
98SOX2_18555785_Chip-Seq_ESCs_Mouse0.89214188
99KLF4_18555785_Chip-Seq_ESCs_Mouse0.88146184
100XRN2_22483619_ChIP-Seq_HELA_Human0.87253382

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000604_amyloidosis5.24662550
2MP0003300_gastrointestinal_ulcer4.54345304
3MP0001835_abnormal_antigen_presentation4.38103067
4MP0000465_gastrointestinal_hemorrhage4.01486504
5MP0003329_amyloid_beta_deposits3.66292009
6MP0005671_abnormal_response_to3.12775116
7MP0003806_abnormal_nucleotide_metabolis3.08914124
8MP0002102_abnormal_ear_morphology2.86184140
9MP0001853_heart_inflammation2.76108273
10MP0003786_premature_aging2.74182080
11MP0000685_abnormal_immune_system2.50537923
12MP0003763_abnormal_thymus_physiology2.28632062
13MP0004885_abnormal_endolymph2.10032775
14MP0002876_abnormal_thyroid_physiology1.94448231
15MP0003718_maternal_effect1.92518766
16MP0002736_abnormal_nociception_after1.83540253
17MP0000372_irregular_coat_pigmentation1.78399934
18MP0008877_abnormal_DNA_methylation1.73651390
19MP0008875_abnormal_xenobiotic_pharmacok1.69367948
20MP0002148_abnormal_hypersensitivity_rea1.68906938
21MP0001790_abnormal_immune_system1.67778671
22MP0005387_immune_system_phenotype1.67778671
23MP0004782_abnormal_surfactant_physiolog1.58707330
24MP0009840_abnormal_foam_cell1.53951532
25MP0009333_abnormal_splenocyte_physiolog1.53427828
26MP0008789_abnormal_olfactory_epithelium1.53244905
27MP0003191_abnormal_cellular_cholesterol1.50567747
28MP0010094_abnormal_chromosome_stability1.46084728
29MP0001800_abnormal_humoral_immune1.42234519
30MP0006292_abnormal_olfactory_placode1.42085995
31MP0002405_respiratory_system_inflammati1.41737297
32MP0002837_dystrophic_cardiac_calcinosis1.40365587
33MP0001968_abnormal_touch/_nociception1.36860767
34MP0002234_abnormal_pharynx_morphology1.32068671
35MP0001873_stomach_inflammation1.30579826
36MP0008007_abnormal_cellular_replicative1.30308857
37MP0009697_abnormal_copulation1.30185866
38MP0006036_abnormal_mitochondrial_physio1.30102309
39MP0003878_abnormal_ear_physiology1.29429607
40MP0005377_hearing/vestibular/ear_phenot1.29429607
41MP0002138_abnormal_hepatobiliary_system1.26773424
42MP0005000_abnormal_immune_tolerance1.25712469
43MP0003693_abnormal_embryo_hatching1.25185313
44MP0002723_abnormal_immune_serum1.19590155
45MP0005025_abnormal_response_to1.17569632
46MP0008872_abnormal_physiological_respon1.17387522
47MP0004957_abnormal_blastocyst_morpholog1.16482526
48MP0003195_calcinosis1.15866019
49MP0003011_delayed_dark_adaptation1.15486774
50MP0001348_abnormal_lacrimal_gland1.11381114
51MP0005645_abnormal_hypothalamus_physiol1.10301146
52MP0006072_abnormal_retinal_apoptosis1.09504629
53MP0000703_abnormal_thymus_morphology1.03261140
54MP0002420_abnormal_adaptive_immunity1.00543162
55MP0001819_abnormal_immune_cell0.99720276
56MP0002398_abnormal_bone_marrow0.99559961
57MP0001529_abnormal_vocalization0.98981615
58MP0002277_abnormal_respiratory_mucosa0.98980100
59MP0003252_abnormal_bile_duct0.98508356
60MP0000689_abnormal_spleen_morphology0.98498903
61MP0002163_abnormal_gland_morphology0.98233902
62MP0002722_abnormal_immune_system0.97952247
63MP0000049_abnormal_middle_ear0.97720869
64MP0001119_abnormal_female_reproductive0.96365235
65MP0004145_abnormal_muscle_electrophysio0.94297028
66MP0005360_urolithiasis0.93069805
67MP0002452_abnormal_antigen_presenting0.91045243
68MP0008057_abnormal_DNA_replication0.89670121
69MP0003866_abnormal_defecation0.88620423
70MP0005410_abnormal_fertilization0.86598159
71MP0010155_abnormal_intestine_physiology0.86099419
72MP0001881_abnormal_mammary_gland0.85432410
73MP0002796_impaired_skin_barrier0.85076798
74MP0003724_increased_susceptibility_to0.84882797
75MP0005499_abnormal_olfactory_system0.84414251
76MP0005394_taste/olfaction_phenotype0.84414251
77MP0008058_abnormal_DNA_repair0.84095715
78MP0002210_abnormal_sex_determination0.84002340
79MP0000716_abnormal_immune_system0.83940785
80MP0009785_altered_susceptibility_to0.83776810
81MP0001485_abnormal_pinna_reflex0.81206127
82MP0009278_abnormal_bone_marrow0.79854180
83MP0002429_abnormal_blood_cell0.73962239
84MP0003941_abnormal_skin_development0.73799264
85MP0004147_increased_porphyrin_level0.73575691
86MP0003646_muscle_fatigue0.72591936
87MP0009379_abnormal_foot_pigmentation0.72040124
88MP0004043_abnormal_pH_regulation0.71211718
89MP0005646_abnormal_pituitary_gland0.70924157
90MP0001845_abnormal_inflammatory_respons0.69779081
91MP0001501_abnormal_sleep_pattern0.69538899
92MP0010329_abnormal_lipoprotein_level0.69455982
93MP0003077_abnormal_cell_cycle0.67966014
94MP0001929_abnormal_gametogenesis0.67762307
95MP0001346_abnormal_lacrimal_gland0.66764180
96MP0006035_abnormal_mitochondrial_morpho0.65456342
97MP0005551_abnormal_eye_electrophysiolog0.65445209
98MP0002693_abnormal_pancreas_physiology0.63442271
99MP0002229_neurodegeneration0.63319399
100MP0000631_abnormal_neuroendocrine_gland0.60361048

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)9.72782943
2Increased IgM level (HP:0003496)5.78379554
3IgG deficiency (HP:0004315)5.50489727
4IgA deficiency (HP:0002720)4.89701373
5Elevated erythrocyte sedimentation rate (HP:0003565)4.23815638
6Absent rod-and cone-mediated responses on ERG (HP:0007688)4.23216666
7Abnormality of T cell physiology (HP:0011840)4.16997746
83-Methylglutaconic aciduria (HP:0003535)3.86728513
9Hypoplasia of the pons (HP:0012110)3.56396909
10Abnormality of T cells (HP:0002843)3.34802996
11Poor head control (HP:0002421)3.32465794
12Colon cancer (HP:0003003)3.29640986
13Testicular atrophy (HP:0000029)3.26543800
14Abnormal number of erythroid precursors (HP:0012131)3.25577214
15Abnormality of the pons (HP:0007361)3.24336669
16Limb dystonia (HP:0002451)3.22005935
17Abnormal rod and cone electroretinograms (HP:0008323)3.05656673
18Parakeratosis (HP:0001036)2.98290822
19Dysphonia (HP:0001618)2.96792073
20Dyschromatopsia (HP:0007641)2.86778679
21Abnormality of cells of the erythroid lineage (HP:0012130)2.84120311
22Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.82614763
23Acute necrotizing encephalopathy (HP:0006965)2.80010255
24Lipid accumulation in hepatocytes (HP:0006561)2.78183890
25Abnormality of incisor morphology (HP:0011063)2.68690034
26Type 2 muscle fiber atrophy (HP:0003554)2.66805151
27Erythroderma (HP:0001019)2.64160254
28IgM deficiency (HP:0002850)2.62508662
29Pancytopenia (HP:0001876)2.62297508
30Bile duct proliferation (HP:0001408)2.61161534
31Abnormal biliary tract physiology (HP:0012439)2.61161534
32Hypergammaglobulinemia (HP:0010702)2.49445040
33Sensory axonal neuropathy (HP:0003390)2.48390486
34Acute encephalopathy (HP:0006846)2.45746298
35Increased CSF lactate (HP:0002490)2.43516477
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.43206265
37Abnormal mitochondria in muscle tissue (HP:0008316)2.42828633
38Oral leukoplakia (HP:0002745)2.41368713
39Abnormality of the prostate (HP:0008775)2.39913556
40B lymphocytopenia (HP:0010976)2.38917361
41Mitochondrial inheritance (HP:0001427)2.38312989
42Severe combined immunodeficiency (HP:0004430)2.34709953
43Duplicated collecting system (HP:0000081)2.34594036
44Abnormality of B cell number (HP:0010975)2.33547294
45Neutropenia (HP:0001875)2.32158409
46Hyperglycinuria (HP:0003108)2.29816475
47Prostate neoplasm (HP:0100787)2.28410541
48Multiple enchondromatosis (HP:0005701)2.27168493
49Alopecia of scalp (HP:0002293)2.25419282
50Reticulocytopenia (HP:0001896)2.24806965
51Supernumerary spleens (HP:0009799)2.23065699
52Abnormality of the renal collecting system (HP:0004742)2.22750753
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.19973320
54Congenital, generalized hypertrichosis (HP:0004540)2.17533479
55Progressive macrocephaly (HP:0004481)2.13445625
56Muscle fiber atrophy (HP:0100295)2.07026120
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05109003
58Methylmalonic acidemia (HP:0002912)2.03900918
59Cerebral edema (HP:0002181)2.03298921
60Palmoplantar hyperkeratosis (HP:0000972)2.02377235
61Increased hepatocellular lipid droplets (HP:0006565)2.01872195
62Congenital ichthyosiform erythroderma (HP:0007431)1.94976375
63Abnormality of T cell number (HP:0011839)1.92206937
64Renal cortical cysts (HP:0000803)1.92027652
65Paralysis (HP:0003470)1.89199580
66T lymphocytopenia (HP:0005403)1.89159205
67Abnormality of the lower motor neuron (HP:0002366)1.86390957
68Microvesicular hepatic steatosis (HP:0001414)1.86130581
69Optic disc pallor (HP:0000543)1.85879373
70Palmar hyperkeratosis (HP:0010765)1.84343932
71Amaurosis fugax (HP:0100576)1.83295802
72Abnormality of the incisor (HP:0000676)1.83105882
73Combined immunodeficiency (HP:0005387)1.82821575
74Thyroiditis (HP:0100646)1.81392583
75Type I transferrin isoform profile (HP:0003642)1.80802801
76Pustule (HP:0200039)1.80562908
77Myositis (HP:0100614)1.80055463
78Methylmalonic aciduria (HP:0012120)1.78611882
79Chronic diarrhea (HP:0002028)1.75353162
80Pallor (HP:0000980)1.72230404
81Gonadotropin excess (HP:0000837)1.71250715
82Increased serum lactate (HP:0002151)1.70174136
83Hepatocellular necrosis (HP:0001404)1.69477135
84Increased muscle lipid content (HP:0009058)1.67886294
85Gangrene (HP:0100758)1.66922976
86Dicarboxylic aciduria (HP:0003215)1.65708011
87Abnormality of dicarboxylic acid metabolism (HP:0010995)1.65708011
88Cleft eyelid (HP:0000625)1.65159697
89Constricted visual fields (HP:0001133)1.64983688
90Pendular nystagmus (HP:0012043)1.63517856
91Exertional dyspnea (HP:0002875)1.62949659
92Abnormality of male internal genitalia (HP:0000022)1.62513879
93Absent septum pellucidum (HP:0001331)1.62433643
94Keratoconjunctivitis (HP:0001096)1.62017333
95Abnormality of glycine metabolism (HP:0010895)1.60804350
96Abnormality of serine family amino acid metabolism (HP:0010894)1.60804350
97Clubbing of toes (HP:0100760)1.60709095
98Abnormality of placental membranes (HP:0011409)1.60681829
99Amniotic constriction ring (HP:0009775)1.60681829
100Abnormality of the labia minora (HP:0012880)1.59485270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.94095006
2SCYL23.48331034
3EIF2AK33.00205764
4MKNK22.93383020
5ZAK2.89332944
6NUAK12.81580915
7STK392.79733099
8TXK2.61690471
9BUB12.47355519
10OXSR12.39771615
11ADRBK22.39635775
12NME12.37245114
13VRK22.35677216
14TEC2.23652101
15WNK42.16356084
16MKNK12.13403708
17PRPF4B2.06886956
18NEK12.00873642
19TLK11.90267603
20TESK21.89469256
21GRK11.88085649
22TAOK21.87463873
23PASK1.87379841
24TAF11.76794053
25FES1.71668520
26CSK1.64994672
27PAK41.64445271
28VRK11.60835497
29ITK1.50952203
30WNK31.34206225
31ACVR1B1.33334924
32TESK11.29541710
33EIF2AK21.29116542
34MST41.28709997
35DYRK21.25364536
36LIMK11.25265022
37PLK31.24419630
38MAP3K41.24235151
39FRK1.20773031
40NME21.04419205
41STK161.03790452
42RPS6KA51.02725071
43KDR1.01185026
44MAPKAPK50.97205571
45CLK10.93304628
46IKBKB0.91062472
47BTK0.89146653
48PLK40.84448423
49FLT30.81548410
50MAP2K20.76505734
51SRPK10.75088678
52ERBB30.74925397
53CDC70.72720761
54TTK0.72385035
55IKBKE0.71268785
56GRK50.70967255
57TSSK60.70960824
58INSRR0.69260283
59IRAK40.65856450
60PLK10.64886053
61PRKCQ0.64174249
62BCKDK0.62358937
63LCK0.61199886
64WNK10.58224228
65PAK20.53575487
66ATR0.52956088
67PBK0.52878573
68FGFR10.50958921
69ADRBK10.50236136
70LYN0.48324598
71HCK0.42960685
72PLK20.41615077
73CSNK1A1L0.40912846
74WEE10.40260928
75DAPK20.39950992
76MATK0.39654310
77BCR0.39433616
78SYK0.36284734
79CSNK2A20.35878392
80PRKCG0.35720376
81STK40.33615887
82INSR0.33548970
83AURKB0.32221760
84CHEK10.30293700
85CSNK1G30.29482267
86CSNK2A10.28994989
87BMPR1B0.27999012
88RPS6KA60.27446462
89IGF1R0.27284728
90ZAP700.27005221
91RPS6KB20.24939126
92BLK0.23968698
93MELK0.23961091
94MAP4K20.23122708
95TYRO30.23064331
96CDK70.22635138
97ATM0.21896192
98TIE10.21775744
99TGFBR10.20605933
100BMPR20.20223865

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.58470823
2Vitamin B6 metabolism_Homo sapiens_hsa007504.24445866
3Primary immunodeficiency_Homo sapiens_hsa053403.94672429
4Asthma_Homo sapiens_hsa053103.16835957
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.14204304
6Allograft rejection_Homo sapiens_hsa053302.94534687
7Ribosome_Homo sapiens_hsa030102.90125912
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.88495343
9Autoimmune thyroid disease_Homo sapiens_hsa053202.79686505
10Protein export_Homo sapiens_hsa030602.75109782
11Oxidative phosphorylation_Homo sapiens_hsa001902.28475740
12RNA polymerase_Homo sapiens_hsa030202.17592225
13Mismatch repair_Homo sapiens_hsa034301.98426111
14Parkinsons disease_Homo sapiens_hsa050121.87356594
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.83651042
16RNA transport_Homo sapiens_hsa030131.75325659
17Graft-versus-host disease_Homo sapiens_hsa053321.70747479
18T cell receptor signaling pathway_Homo sapiens_hsa046601.70425830
19Caffeine metabolism_Homo sapiens_hsa002321.64618996
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60935422
21DNA replication_Homo sapiens_hsa030301.59603702
22Linoleic acid metabolism_Homo sapiens_hsa005911.59564656
23Homologous recombination_Homo sapiens_hsa034401.55373899
24Spliceosome_Homo sapiens_hsa030401.54255464
25Type I diabetes mellitus_Homo sapiens_hsa049401.53884908
26One carbon pool by folate_Homo sapiens_hsa006701.42808745
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33794438
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29689462
29Pyrimidine metabolism_Homo sapiens_hsa002401.28157517
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24624223
31Hematopoietic cell lineage_Homo sapiens_hsa046401.24515250
32Basal transcription factors_Homo sapiens_hsa030221.23779306
33Alzheimers disease_Homo sapiens_hsa050101.19849309
34Fanconi anemia pathway_Homo sapiens_hsa034601.19599899
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19013597
36Rheumatoid arthritis_Homo sapiens_hsa053231.18187344
37Huntingtons disease_Homo sapiens_hsa050161.15323098
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14645244
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.12890489
40RNA degradation_Homo sapiens_hsa030181.07949015
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06549885
42Base excision repair_Homo sapiens_hsa034101.06363676
43Nucleotide excision repair_Homo sapiens_hsa034200.86055521
44Purine metabolism_Homo sapiens_hsa002300.85355952
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.84409014
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82377538
47Ether lipid metabolism_Homo sapiens_hsa005650.79425897
48Malaria_Homo sapiens_hsa051440.78737756
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78421979
50Viral myocarditis_Homo sapiens_hsa054160.76198563
51Antigen processing and presentation_Homo sapiens_hsa046120.75376234
52Peroxisome_Homo sapiens_hsa041460.72688933
53Folate biosynthesis_Homo sapiens_hsa007900.68848630
54Propanoate metabolism_Homo sapiens_hsa006400.68721823
55Sulfur metabolism_Homo sapiens_hsa009200.67981961
56Selenocompound metabolism_Homo sapiens_hsa004500.67721570
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66322906
58Cardiac muscle contraction_Homo sapiens_hsa042600.63370911
59Phototransduction_Homo sapiens_hsa047440.62885955
60Measles_Homo sapiens_hsa051620.62009038
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.59600951
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58370069
63Apoptosis_Homo sapiens_hsa042100.58160528
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56956701
65Arachidonic acid metabolism_Homo sapiens_hsa005900.52838902
66Retinol metabolism_Homo sapiens_hsa008300.50931802
67Epstein-Barr virus infection_Homo sapiens_hsa051690.49128177
68beta-Alanine metabolism_Homo sapiens_hsa004100.47967434
69Systemic lupus erythematosus_Homo sapiens_hsa053220.47295807
70Tryptophan metabolism_Homo sapiens_hsa003800.47208565
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46562107
72Legionellosis_Homo sapiens_hsa051340.46287249
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46168971
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.44405362
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43919575
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43437404
77TNF signaling pathway_Homo sapiens_hsa046680.42421349
78mRNA surveillance pathway_Homo sapiens_hsa030150.37602517
79Chemical carcinogenesis_Homo sapiens_hsa052040.35516793
80Non-homologous end-joining_Homo sapiens_hsa034500.34257172
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33584500
82Metabolic pathways_Homo sapiens_hsa011000.32780404
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29475916
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29418599
85Ovarian steroidogenesis_Homo sapiens_hsa049130.26457914
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24407575
87p53 signaling pathway_Homo sapiens_hsa041150.23418345
88Fat digestion and absorption_Homo sapiens_hsa049750.23188695
89HTLV-I infection_Homo sapiens_hsa051660.22316828
90Nitrogen metabolism_Homo sapiens_hsa009100.21647079
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21001733
92Nicotine addiction_Homo sapiens_hsa050330.20866024
93Butanoate metabolism_Homo sapiens_hsa006500.20621852
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18275185
95Fatty acid elongation_Homo sapiens_hsa000620.17311600
96Starch and sucrose metabolism_Homo sapiens_hsa005000.16436437
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16410709
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15985850
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.15366895
100Cell cycle_Homo sapiens_hsa041100.14854529

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