HSPD1P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of isotype switching to IgG isotypes (GO:0048302)6.45940964
2positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.56964760
3regulation of immunoglobulin secretion (GO:0051023)5.43066798
4proteasome assembly (GO:0043248)5.08370839
5DNA deamination (GO:0045006)4.85000434
6regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.82247759
7ribosome assembly (GO:0042255)4.21462817
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.06107652
9DNA double-strand break processing (GO:0000729)3.86463740
10somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.83381789
11isotype switching (GO:0045190)3.83381789
12somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.83381789
13maturation of SSU-rRNA (GO:0030490)3.81625447
14positive regulation of isotype switching (GO:0045830)3.81429806
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.75821292
16rRNA modification (GO:0000154)3.74552294
17positive regulation of DNA recombination (GO:0045911)3.65274608
18GTP biosynthetic process (GO:0006183)3.60989984
19exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53945667
20regulation of cellular amino acid metabolic process (GO:0006521)3.53356207
21transcription elongation from RNA polymerase III promoter (GO:0006385)3.53352768
22termination of RNA polymerase III transcription (GO:0006386)3.53352768
23rRNA methylation (GO:0031167)3.48948867
24tRNA aminoacylation (GO:0043039)3.48343632
25amino acid activation (GO:0043038)3.48343632
26water-soluble vitamin biosynthetic process (GO:0042364)3.46834289
27cullin deneddylation (GO:0010388)3.46702727
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46531066
29ribosome biogenesis (GO:0042254)3.43195473
30negative regulation of DNA-dependent DNA replication (GO:2000104)3.41479047
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.40558761
32pseudouridine synthesis (GO:0001522)3.40096509
33RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.39914812
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.39866498
35DNA damage response, detection of DNA damage (GO:0042769)3.37788712
36negative regulation of ligase activity (GO:0051352)3.35573015
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.35573015
38positive regulation of interleukin-17 production (GO:0032740)3.33791101
39tRNA aminoacylation for protein translation (GO:0006418)3.33444003
40chaperone-mediated protein transport (GO:0072321)3.29877138
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28065453
42somatic hypermutation of immunoglobulin genes (GO:0016446)3.28065453
43rRNA processing (GO:0006364)3.26805208
44folic acid-containing compound biosynthetic process (GO:0009396)3.26314113
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.22280307
46rRNA metabolic process (GO:0016072)3.21809830
47somatic diversification of immunoglobulins (GO:0016445)3.20866306
48signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.20338887
49signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.20338887
50signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.20338887
51UTP biosynthetic process (GO:0006228)3.20058620
52anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18356767
53negative regulation of DNA recombination (GO:0045910)3.15739164
54signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.14490672
55intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.14490672
56signal transduction involved in DNA damage checkpoint (GO:0072422)3.11972329
57signal transduction involved in DNA integrity checkpoint (GO:0072401)3.11972329
58respiratory chain complex IV assembly (GO:0008535)3.11946217
59protein deneddylation (GO:0000338)3.10516505
60spliceosomal snRNP assembly (GO:0000387)3.09480183
61somatic recombination of immunoglobulin gene segments (GO:0016447)3.08494323
62signal transduction involved in cell cycle checkpoint (GO:0072395)3.07225221
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.06456406
64tRNA metabolic process (GO:0006399)3.05778169
65DNA catabolic process, exonucleolytic (GO:0000738)2.99537951
66IMP biosynthetic process (GO:0006188)2.97337312
67ncRNA metabolic process (GO:0034660)2.96970789
68synapsis (GO:0007129)2.96476198
69energy coupled proton transport, down electrochemical gradient (GO:0015985)2.93317612
70ATP synthesis coupled proton transport (GO:0015986)2.93317612
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.92366222
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.92366222
73termination of RNA polymerase I transcription (GO:0006363)2.92199776
74protein refolding (GO:0042026)2.91998012
75positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.91650450
76cytidine catabolic process (GO:0006216)2.91169042
77cytidine deamination (GO:0009972)2.91169042
78cytidine metabolic process (GO:0046087)2.91169042
79regulation of podosome assembly (GO:0071801)2.90463053
80mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86529115
81mitochondrial respiratory chain complex I assembly (GO:0032981)2.86529115
82NADH dehydrogenase complex assembly (GO:0010257)2.86529115
83tRNA processing (GO:0008033)2.82068485
84positive regulation of ligase activity (GO:0051351)2.79991329
85regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.79288202
86maturation of 5.8S rRNA (GO:0000460)2.79235638
87signal peptide processing (GO:0006465)2.79233791
88ribosomal large subunit biogenesis (GO:0042273)2.78950965
89UTP metabolic process (GO:0046051)2.78355807
90protein targeting to mitochondrion (GO:0006626)2.77743969
91transcription elongation from RNA polymerase I promoter (GO:0006362)2.75997974
92CTP metabolic process (GO:0046036)2.75374204
93CTP biosynthetic process (GO:0006241)2.75374204
94ncRNA processing (GO:0034470)2.75226013
95ribonucleoprotein complex biogenesis (GO:0022613)2.74593264
96regulation of immunoglobulin production (GO:0002637)2.73405123
97mitochondrial RNA metabolic process (GO:0000959)2.72907110
98positive regulation of immunoglobulin production (GO:0002639)2.72370461
99mitochondrial respiratory chain complex assembly (GO:0033108)2.72294065
100behavioral response to nicotine (GO:0035095)2.71032891

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.23113445
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.35499800
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.15709835
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.87596881
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97000911
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.93242853
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.92697772
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.92025074
9ELK1_19687146_ChIP-ChIP_HELA_Human2.90602339
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.85021719
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.83883578
12VDR_23849224_ChIP-Seq_CD4+_Human2.81495486
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.77386817
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.66467754
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.60757072
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56798735
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47722933
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44265219
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41257591
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40148710
21FOXP3_21729870_ChIP-Seq_TREG_Human2.35528560
22ZNF274_21170338_ChIP-Seq_K562_Hela2.27229680
23PCGF2_27294783_Chip-Seq_ESCs_Mouse2.21250148
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.09567835
25PADI4_21655091_ChIP-ChIP_MCF-7_Human2.03105528
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02427174
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86908686
28E2F7_22180533_ChIP-Seq_HELA_Human1.85115338
29VDR_22108803_ChIP-Seq_LS180_Human1.82680876
30DCP1A_22483619_ChIP-Seq_HELA_Human1.81576846
31EWS_26573619_Chip-Seq_HEK293_Human1.80761468
32TAF15_26573619_Chip-Seq_HEK293_Human1.80454533
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78367481
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75574868
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75471375
36MYC_18940864_ChIP-ChIP_HL60_Human1.72151368
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69995395
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.68610579
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.64757930
40TTF2_22483619_ChIP-Seq_HELA_Human1.63393650
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55928357
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55790435
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53911701
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42833345
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41642978
46TP53_22573176_ChIP-Seq_HFKS_Human1.38458133
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36308419
48FUS_26573619_Chip-Seq_HEK293_Human1.35924780
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35256714
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.34089918
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.34001203
52GABP_19822575_ChIP-Seq_HepG2_Human1.33447162
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32955896
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32844670
55XRN2_22483619_ChIP-Seq_HELA_Human1.30841010
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29432237
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29224084
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28583646
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27457535
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26508913
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26396992
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23987182
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23793025
64P300_19829295_ChIP-Seq_ESCs_Human1.22192303
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.21224954
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20192524
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19946506
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.19253269
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16743535
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11827933
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08554229
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08317524
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03252053
74LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03069377
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02108488
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00198654
77E2F1_21310950_ChIP-Seq_MCF-7_Human0.99601433
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98516558
79IRF1_19129219_ChIP-ChIP_H3396_Human0.97657998
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97496986
81SOX2_16153702_ChIP-ChIP_HESCs_Human0.97189109
82SOX2_19829295_ChIP-Seq_ESCs_Human0.96019216
83NANOG_19829295_ChIP-Seq_ESCs_Human0.96019216
84PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95468060
85CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94770473
86ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94152132
87BP1_19119308_ChIP-ChIP_Hs578T_Human0.93401563
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93157835
89CRX_20693478_ChIP-Seq_RETINA_Mouse0.92216161
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91757347
91FOXA1_25329375_ChIP-Seq_VCAP_Human0.91240346
92FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91240346
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90625778
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89375338
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87160358
96GATA3_26560356_Chip-Seq_TH2_Human0.83109745
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.81731070
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.80909261
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.80399811
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79850011

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.50631065
2MP0002138_abnormal_hepatobiliary_system3.49540811
3MP0008877_abnormal_DNA_methylation3.46560995
4MP0001873_stomach_inflammation3.38437042
5MP0001348_abnormal_lacrimal_gland3.03837335
6MP0005671_abnormal_response_to2.94034378
7MP0003693_abnormal_embryo_hatching2.75752883
8MP0003786_premature_aging2.71891961
9MP0008875_abnormal_xenobiotic_pharmacok2.51604271
10MP0005084_abnormal_gallbladder_morpholo2.45167133
11MP0010094_abnormal_chromosome_stability2.39118139
12MP0006072_abnormal_retinal_apoptosis2.36373439
13MP0008872_abnormal_physiological_respon2.29546353
14MP0008058_abnormal_DNA_repair2.29268409
15MP0004147_increased_porphyrin_level2.27231151
16MP0004957_abnormal_blastocyst_morpholog2.08398890
17MP0005387_immune_system_phenotype2.04833626
18MP0001790_abnormal_immune_system2.04833626
19MP0005645_abnormal_hypothalamus_physiol2.02614213
20MP0003718_maternal_effect1.96154753
21MP0000569_abnormal_digit_pigmentation1.73878215
22MP0006292_abnormal_olfactory_placode1.72077930
23MP0001853_heart_inflammation1.71933865
24MP0008007_abnormal_cellular_replicative1.71922335
25MP0002736_abnormal_nociception_after1.68374991
26MP0004742_abnormal_vestibular_system1.60354380
27MP0002102_abnormal_ear_morphology1.58036296
28MP0003806_abnormal_nucleotide_metabolis1.53587170
29MP0004782_abnormal_surfactant_physiolog1.47037737
30MP0001800_abnormal_humoral_immune1.45870300
31MP0003111_abnormal_nucleus_morphology1.40703208
32MP0008789_abnormal_olfactory_epithelium1.39975644
33MP0009333_abnormal_splenocyte_physiolog1.30819702
34MP0008995_early_reproductive_senescence1.30518649
35MP0002277_abnormal_respiratory_mucosa1.29710454
36MP0003195_calcinosis1.28800750
37MP0001968_abnormal_touch/_nociception1.27439830
38MP0002148_abnormal_hypersensitivity_rea1.25877309
39MP0002405_respiratory_system_inflammati1.22736755
40MP0006036_abnormal_mitochondrial_physio1.22452374
41MP0001984_abnormal_olfaction1.22201612
42MP0005253_abnormal_eye_physiology1.20645888
43MP0000465_gastrointestinal_hemorrhage1.19549926
44MP0002160_abnormal_reproductive_system1.18971341
45MP0005551_abnormal_eye_electrophysiolog1.17943073
46MP0000685_abnormal_immune_system1.17273240
47MP0003878_abnormal_ear_physiology1.16933165
48MP0005377_hearing/vestibular/ear_phenot1.16933165
49MP0009785_altered_susceptibility_to1.15692237
50MP0002254_reproductive_system_inflammat1.12649555
51MP0003646_muscle_fatigue1.12476573
52MP0003077_abnormal_cell_cycle1.09411968
53MP0003186_abnormal_redox_activity1.09089268
54MP0003567_abnormal_fetal_cardiomyocyte1.07302338
55MP0002210_abnormal_sex_determination1.07124236
56MP0006035_abnormal_mitochondrial_morpho1.06994260
57MP0005389_reproductive_system_phenotype1.06047403
58MP0002938_white_spotting1.02626007
59MP0001293_anophthalmia1.02581507
60MP0005000_abnormal_immune_tolerance1.01594293
61MP0000372_irregular_coat_pigmentation1.01295077
62MP0002163_abnormal_gland_morphology1.01042028
63MP0001485_abnormal_pinna_reflex0.99390803
64MP0003011_delayed_dark_adaptation0.98045276
65MP0005187_abnormal_penis_morphology0.95579833
66MP0000653_abnormal_sex_gland0.91237446
67MP0005310_abnormal_salivary_gland0.90601685
68MP0003763_abnormal_thymus_physiology0.88955793
69MP0001502_abnormal_circadian_rhythm0.88682500
70MP0002723_abnormal_immune_serum0.88184093
71MP0005499_abnormal_olfactory_system0.87930327
72MP0005394_taste/olfaction_phenotype0.87930327
73MP0001119_abnormal_female_reproductive0.87906594
74MP0003936_abnormal_reproductive_system0.87137282
75MP0002693_abnormal_pancreas_physiology0.86623183
76MP0001929_abnormal_gametogenesis0.86226259
77MP0004215_abnormal_myocardial_fiber0.84591476
78MP0005379_endocrine/exocrine_gland_phen0.82330119
79MP0001529_abnormal_vocalization0.81040472
80MP0001663_abnormal_digestive_system0.77698187
81MP0005636_abnormal_mineral_homeostasis0.77458959
82MP0005408_hypopigmentation0.77286151
83MP0002751_abnormal_autonomic_nervous0.76795839
84MP0002272_abnormal_nervous_system0.76768736
85MP0002638_abnormal_pupillary_reflex0.76446805
86MP0005646_abnormal_pituitary_gland0.76008732
87MP0005075_abnormal_melanosome_morpholog0.75981871
88MP0002095_abnormal_skin_pigmentation0.75837963
89MP0001145_abnormal_male_reproductive0.75676118
90MP0000631_abnormal_neuroendocrine_gland0.74046901
91MP0000647_abnormal_sebaceous_gland0.74023448
92MP0000689_abnormal_spleen_morphology0.72663275
93MP0001986_abnormal_taste_sensitivity0.72591581
94MP0001764_abnormal_homeostasis0.71833705
95MP0004142_abnormal_muscle_tone0.71474669
96MP0010155_abnormal_intestine_physiology0.70506733
97MP0009745_abnormal_behavioral_response0.68926005
98MP0004145_abnormal_muscle_electrophysio0.68439089
99MP0003866_abnormal_defecation0.67913056
100MP0005395_other_phenotype0.67669619

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.78662706
2Lipid accumulation in hepatocytes (HP:0006561)4.35394043
3Stomatitis (HP:0010280)4.04786791
4Acute necrotizing encephalopathy (HP:0006965)3.69909316
5Mitochondrial inheritance (HP:0001427)3.57931460
6Increased CSF lactate (HP:0002490)3.55252477
7Exertional dyspnea (HP:0002875)3.46883523
8Acute encephalopathy (HP:0006846)3.43616276
9Aplastic anemia (HP:0001915)3.39855053
103-Methylglutaconic aciduria (HP:0003535)3.39548654
11Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.34649323
12Renal Fanconi syndrome (HP:0001994)3.33258011
13Methylmalonic acidemia (HP:0002912)3.25573303
14Abnormality of the labia minora (HP:0012880)3.18896739
15IgG deficiency (HP:0004315)3.17953532
16Abnormal mitochondria in muscle tissue (HP:0008316)3.11944042
17Progressive macrocephaly (HP:0004481)3.08471448
18Colon cancer (HP:0003003)3.03191423
19Increased intramyocellular lipid droplets (HP:0012240)2.99331460
20Hepatocellular necrosis (HP:0001404)2.97998479
21Methylmalonic aciduria (HP:0012120)2.94363449
22Increased serum lactate (HP:0002151)2.83451269
23Abolished electroretinogram (ERG) (HP:0000550)2.79650429
24Hepatic necrosis (HP:0002605)2.78777240
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.75813573
26Abnormality of alanine metabolism (HP:0010916)2.75813573
27Hyperalaninemia (HP:0003348)2.75813573
28Pancreatic cysts (HP:0001737)2.57178197
29Respiratory difficulties (HP:0002880)2.56093545
30Molar tooth sign on MRI (HP:0002419)2.48641302
31Abnormality of midbrain morphology (HP:0002418)2.48641302
32Hyperglycinemia (HP:0002154)2.46522486
33Increased muscle lipid content (HP:0009058)2.45043798
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.44838692
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.43495402
36Cerebral edema (HP:0002181)2.43109964
37Optic disc pallor (HP:0000543)2.39235697
38Chorioretinal atrophy (HP:0000533)2.35047532
39Pancytopenia (HP:0001876)2.29342522
40Nephronophthisis (HP:0000090)2.29067466
41Lactic acidosis (HP:0003128)2.27053988
42Oral leukoplakia (HP:0002745)2.21048125
43Leukodystrophy (HP:0002415)2.20764466
44Hypoproteinemia (HP:0003075)2.19232972
45IgA deficiency (HP:0002720)2.14792191
46Abnormality of serum amino acid levels (HP:0003112)2.13587056
47Renal cortical cysts (HP:0000803)2.12941338
48Congenital stationary night blindness (HP:0007642)2.11914466
49Abnormality of serine family amino acid metabolism (HP:0010894)2.08359936
50Abnormality of glycine metabolism (HP:0010895)2.08359936
51Hyperglycinuria (HP:0003108)2.07615329
52Abnormality of the ileum (HP:0001549)2.05755618
53Exercise intolerance (HP:0003546)2.04000262
54Meckel diverticulum (HP:0002245)2.03843132
55Increased IgM level (HP:0003496)2.03420353
56Increased serum pyruvate (HP:0003542)2.02392501
57Lethargy (HP:0001254)2.02197241
58Abnormality of methionine metabolism (HP:0010901)2.01905501
59Carpal bone hypoplasia (HP:0001498)2.00126067
60Abnormal biliary tract physiology (HP:0012439)1.99583610
61Bile duct proliferation (HP:0001408)1.99583610
62True hermaphroditism (HP:0010459)1.99574488
63Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98325028
64Abnormality of urine glucose concentration (HP:0011016)1.98086038
65Glycosuria (HP:0003076)1.98086038
66Aplasia/hypoplasia of the uterus (HP:0008684)1.96828311
67Abnormality of renal resorption (HP:0011038)1.96084974
68Pancreatic islet-cell hyperplasia (HP:0004510)1.94342233
69Abnormality of the pons (HP:0007361)1.93289509
70Progressive inability to walk (HP:0002505)1.92981285
71Cleft eyelid (HP:0000625)1.91249118
72Respiratory failure (HP:0002878)1.91111584
73Abnormality of homocysteine metabolism (HP:0010919)1.89660539
74Homocystinuria (HP:0002156)1.89660539
75Abnormal lung lobation (HP:0002101)1.88598663
76Microvesicular hepatic steatosis (HP:0001414)1.87568664
77Abnormality of the renal cortex (HP:0011035)1.86725360
78Hypoplasia of the pons (HP:0012110)1.85874050
79Abnormality of the vitamin B12 metabolism (HP:0004341)1.85593010
80Congenital, generalized hypertrichosis (HP:0004540)1.82944320
81Pancreatic fibrosis (HP:0100732)1.82716123
82Neutropenia (HP:0001875)1.82594486
83Prominent metopic ridge (HP:0005487)1.81402810
84Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.79030653
85Degeneration of anterior horn cells (HP:0002398)1.77447547
86Abnormality of the anterior horn cell (HP:0006802)1.77447547
87Abnormality of the renal medulla (HP:0100957)1.75010734
88Rhabdomyosarcoma (HP:0002859)1.73009882
89Hyperphosphaturia (HP:0003109)1.72604125
90Abnormality of vitamin B metabolism (HP:0004340)1.71338948
91Large for gestational age (HP:0001520)1.71246127
92Bilateral microphthalmos (HP:0007633)1.69642577
93Pendular nystagmus (HP:0012043)1.69591598
94Inability to walk (HP:0002540)1.69428836
95Decreased activity of mitochondrial respiratory chain (HP:0008972)1.69127202
96Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.69127202
97Bifid tongue (HP:0010297)1.68718174
98Clitoromegaly (HP:0000057)1.67493417
99Cerebral hypomyelination (HP:0006808)1.66664756
100Abnormality of the preputium (HP:0100587)1.66222084

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.50599491
2BUB14.48247657
3ZAK3.20314379
4EIF2AK33.00301464
5EIF2AK12.98749834
6MST42.91922992
7PBK2.68613095
8NUAK12.48092314
9TXK2.36397384
10NEK12.30075820
11TLK12.24334821
12SRPK12.23723074
13MAP4K22.16850959
14VRK12.00784910
15BMPR1B1.96125184
16PLK31.95081810
17WNK31.74562381
18MKNK21.68903112
19TRIM281.67790216
20NME11.64605488
21VRK21.64331526
22TNIK1.46187134
23TTK1.44248093
24MKNK11.43323951
25ADRBK21.41625316
26CDC71.28778748
27FRK1.27194929
28OXSR11.26995613
29PINK11.23397007
30GRK11.23100633
31RPS6KA41.22706002
32MAP3K121.17340486
33STK161.11545232
34DYRK21.11405814
35PLK40.99209406
36TAF10.96995606
37PLK10.96429409
38WEE10.95117504
39TAOK30.94792856
40BCKDK0.93707294
41BCR0.93481177
42TIE10.93425533
43PAK40.90273898
44PNCK0.87969150
45EIF2AK20.87492863
46CDK80.85410582
47ALK0.84635424
48RPS6KA50.84075577
49CSNK1G10.83054518
50ATR0.82987233
51SIK30.82845076
52CASK0.79388045
53STK40.78473044
54CSNK1G30.76234367
55WNK40.75916942
56ITK0.73047018
57CSNK1A1L0.72322516
58WNK10.71461064
59BRSK20.68733892
60TEC0.68154613
61TGFBR10.67166496
62PASK0.64483923
63CSNK1G20.62561537
64IKBKB0.61582522
65DAPK10.60575578
66MAPKAPK50.59912255
67ACVR1B0.59272468
68MAPK150.59068382
69PLK20.55937745
70CLK10.54699085
71CDK30.52638676
72STK390.51744125
73AURKB0.50624197
74CSNK2A20.49108326
75CSNK2A10.46028970
76CDK90.44661812
77MYLK0.43426215
78BMPR20.42284042
79GRK70.41274470
80AKT30.41245982
81FGFR10.40435342
82DAPK30.36970569
83CHEK10.36932055
84CHEK20.36642399
85CDK190.36621406
86DYRK30.36222952
87ATM0.35682287
88PAK30.34833156
89NME20.34797705
90NLK0.34602650
91INSRR0.32812033
92AURKA0.31799606
93CSNK1A10.30684823
94MAP3K40.30434243
95MAP2K60.30008628
96BLK0.29007614
97AKT20.28953505
98PRKCE0.25019453
99CHUK0.24166024
100CSNK1E0.24044498

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.47691416
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.65750959
3Asthma_Homo sapiens_hsa053102.91347401
4Protein export_Homo sapiens_hsa030602.88760535
5RNA polymerase_Homo sapiens_hsa030202.73037565
6Allograft rejection_Homo sapiens_hsa053302.62643367
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.58603816
8One carbon pool by folate_Homo sapiens_hsa006702.47811932
9Autoimmune thyroid disease_Homo sapiens_hsa053202.36677107
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.21216827
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.20788575
12Mismatch repair_Homo sapiens_hsa034302.13424065
13Oxidative phosphorylation_Homo sapiens_hsa001902.00929651
14Ribosome_Homo sapiens_hsa030101.95588944
15Basal transcription factors_Homo sapiens_hsa030221.86690989
16RNA degradation_Homo sapiens_hsa030181.86011036
17DNA replication_Homo sapiens_hsa030301.85383952
18RNA transport_Homo sapiens_hsa030131.84623159
19Primary immunodeficiency_Homo sapiens_hsa053401.81526443
20Homologous recombination_Homo sapiens_hsa034401.80989715
21Type I diabetes mellitus_Homo sapiens_hsa049401.72685301
22Parkinsons disease_Homo sapiens_hsa050121.68781679
23Spliceosome_Homo sapiens_hsa030401.62777940
24Caffeine metabolism_Homo sapiens_hsa002321.55258681
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51673441
26Graft-versus-host disease_Homo sapiens_hsa053321.51034977
27Propanoate metabolism_Homo sapiens_hsa006401.50359319
28Nucleotide excision repair_Homo sapiens_hsa034201.46023316
29Pyrimidine metabolism_Homo sapiens_hsa002401.43392631
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36869545
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.35613378
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29077089
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27686239
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27482707
35Non-homologous end-joining_Homo sapiens_hsa034501.22417907
36Base excision repair_Homo sapiens_hsa034101.17688022
37Fanconi anemia pathway_Homo sapiens_hsa034601.16980791
38Antigen processing and presentation_Homo sapiens_hsa046121.13567516
39Purine metabolism_Homo sapiens_hsa002301.10955580
40Systemic lupus erythematosus_Homo sapiens_hsa053221.10763045
41Vitamin B6 metabolism_Homo sapiens_hsa007501.07270078
42Rheumatoid arthritis_Homo sapiens_hsa053231.07244571
43Selenocompound metabolism_Homo sapiens_hsa004501.06386928
44Huntingtons disease_Homo sapiens_hsa050161.06174551
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05441306
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03232589
47Butanoate metabolism_Homo sapiens_hsa006501.02747933
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00901647
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88919654
50Linoleic acid metabolism_Homo sapiens_hsa005910.88016853
51Nitrogen metabolism_Homo sapiens_hsa009100.87715655
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.84786963
53mRNA surveillance pathway_Homo sapiens_hsa030150.84465561
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84406462
55Phototransduction_Homo sapiens_hsa047440.78426442
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77779328
57Alzheimers disease_Homo sapiens_hsa050100.74166286
58Hematopoietic cell lineage_Homo sapiens_hsa046400.73281927
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.70636721
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67067700
61Vitamin digestion and absorption_Homo sapiens_hsa049770.65821190
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63994797
63T cell receptor signaling pathway_Homo sapiens_hsa046600.63519102
64Glutathione metabolism_Homo sapiens_hsa004800.61385381
65Peroxisome_Homo sapiens_hsa041460.59843726
66Regulation of autophagy_Homo sapiens_hsa041400.57692348
67Cardiac muscle contraction_Homo sapiens_hsa042600.57649090
68Tryptophan metabolism_Homo sapiens_hsa003800.57201867
69Epstein-Barr virus infection_Homo sapiens_hsa051690.56035451
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50716782
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48474356
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.47365679
73Measles_Homo sapiens_hsa051620.46525106
74Metabolic pathways_Homo sapiens_hsa011000.46364534
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45849848
76Viral myocarditis_Homo sapiens_hsa054160.45706262
77Carbon metabolism_Homo sapiens_hsa012000.45649788
78Pyruvate metabolism_Homo sapiens_hsa006200.45380408
79Ether lipid metabolism_Homo sapiens_hsa005650.45066813
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45003592
81Biosynthesis of amino acids_Homo sapiens_hsa012300.42899149
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41621309
83Cell cycle_Homo sapiens_hsa041100.39288876
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39037228
85beta-Alanine metabolism_Homo sapiens_hsa004100.35901977
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.35573042
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35295818
88Fat digestion and absorption_Homo sapiens_hsa049750.34296278
89Steroid biosynthesis_Homo sapiens_hsa001000.32187135
90Collecting duct acid secretion_Homo sapiens_hsa049660.30839413
91Chemical carcinogenesis_Homo sapiens_hsa052040.30716630
92Fatty acid elongation_Homo sapiens_hsa000620.28205031
93Fatty acid degradation_Homo sapiens_hsa000710.27262321
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26290622
95Fatty acid metabolism_Homo sapiens_hsa012120.26007776
96Mineral absorption_Homo sapiens_hsa049780.23834389
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23427554
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23393146
99Retinol metabolism_Homo sapiens_hsa008300.23044143
100Arachidonic acid metabolism_Homo sapiens_hsa005900.22870826

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