ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.54947656
2	DNA deamination (GO:0045006)	4.82921270
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.13453145
4	ATP synthesis coupled proton transport (GO:0015986)	4.13453145
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.00765249
6	fucose catabolic process (GO:0019317)	3.96840363
7	L-fucose metabolic process (GO:0042354)	3.96840363
8	L-fucose catabolic process (GO:0042355)	3.96840363
9	water-soluble vitamin biosynthetic process (GO:0042364)	3.85191666
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.84748112
11	protein complex biogenesis (GO:0070271)	3.83325354
12	respiratory chain complex IV assembly (GO:0008535)	3.80101456
13	indole-containing compound catabolic process (GO:0042436)	3.79388673
14	indolalkylamine catabolic process (GO:0046218)	3.79388673
15	tryptophan catabolic process (GO:0006569)	3.79388673
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.64936267
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.64936267
18	NADH dehydrogenase complex assembly (GO:0010257)	3.64936267
19	kynurenine metabolic process (GO:0070189)	3.58054798
20	mitochondrial respiratory chain complex assembly (GO:0033108)	3.56171133
21	negative regulation of telomere maintenance (GO:0032205)	3.52979185
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.46645559
23	tryptophan metabolic process (GO:0006568)	3.38668711
24	cytochrome complex assembly (GO:0017004)	3.38323063
25	indolalkylamine metabolic process (GO:0006586)	3.28632029
26	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.25616988
27	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.22321820
28	sulfation (GO:0051923)	3.20664484
29	positive regulation of defense response to virus by host (GO:0002230)	3.10121671
30	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.09116444
31	protein-cofactor linkage (GO:0018065)	3.07649200
32	electron transport chain (GO:0022900)	3.05061143
33	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.01964974
34	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.01964974
35	preassembly of GPI anchor in ER membrane (GO:0016254)	3.00482180
36	response to pheromone (GO:0019236)	3.00301958
37	respiratory electron transport chain (GO:0022904)	2.96191039
38	maturation of 5.8S rRNA (GO:0000460)	2.93548415
39	cellular ketone body metabolic process (GO:0046950)	2.92646367
40	protein neddylation (GO:0045116)	2.90705314
41	pseudouridine synthesis (GO:0001522)	2.90401000
42	negative regulation of mast cell activation (GO:0033004)	2.88237825
43	positive regulation of fatty acid transport (GO:2000193)	2.87778880
44	platelet dense granule organization (GO:0060155)	2.86653063
45	positive regulation of prostaglandin secretion (GO:0032308)	2.84536518
46	neuronal action potential (GO:0019228)	2.84119957
47	detection of light stimulus involved in sensory perception (GO:0050962)	2.83144889
48	detection of light stimulus involved in visual perception (GO:0050908)	2.83144889
49	piRNA metabolic process (GO:0034587)	2.77890415
50	regulation of action potential (GO:0098900)	2.76011622
51	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.74110019
52	regulation of mesoderm development (GO:2000380)	2.71916421
53	nephron tubule morphogenesis (GO:0072078)	2.71849155
54	nephron epithelium morphogenesis (GO:0072088)	2.71849155
55	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.70936105
56	cytidine deamination (GO:0009972)	2.70410327
57	cytidine metabolic process (GO:0046087)	2.70410327
58	cytidine catabolic process (GO:0006216)	2.70410327
59	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.68543737
60	termination of RNA polymerase III transcription (GO:0006386)	2.68543737
61	rhodopsin mediated signaling pathway (GO:0016056)	2.67333915
62	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.66886138
63	synaptic transmission, cholinergic (GO:0007271)	2.66580064
64	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.66540697
65	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.66333724
66	intracellular protein transmembrane import (GO:0044743)	2.64955325
67	protein polyglutamylation (GO:0018095)	2.63358136
68	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.61384157
69	epithelial cilium movement (GO:0003351)	2.60909461
70	ketone body metabolic process (GO:1902224)	2.60343047
71	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.59960537
72	proton transport (GO:0015992)	2.59510048
73	mannosylation (GO:0097502)	2.59120963
74	kidney morphogenesis (GO:0060993)	2.58472231
75	somite development (GO:0061053)	2.56400926
76	hydrogen ion transmembrane transport (GO:1902600)	2.55816519
77	axoneme assembly (GO:0035082)	2.54404287
78	indole-containing compound metabolic process (GO:0042430)	2.54381898
79	hydrogen transport (GO:0006818)	2.52931636
80	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.48235739
81	dopamine transport (GO:0015872)	2.46686549
82	regulation of hippo signaling (GO:0035330)	2.45073632
83	negative regulation of T cell differentiation in thymus (GO:0033085)	2.43341123
84	regulation of mitotic spindle checkpoint (GO:1903504)	2.42282179
85	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.42282179
86	ATP biosynthetic process (GO:0006754)	2.42144454
87	rRNA modification (GO:0000154)	2.42097440
88	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.40099537
89	cellular response to ATP (GO:0071318)	2.38575757
90	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.38007748
91	maturation of SSU-rRNA (GO:0030490)	2.37813232
92	positive regulation of icosanoid secretion (GO:0032305)	2.37591189
93	protein localization to cilium (GO:0061512)	2.35276658
94	gamma-aminobutyric acid transport (GO:0015812)	2.33775803
95	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.33084986
96	amine catabolic process (GO:0009310)	2.33062868
97	cellular biogenic amine catabolic process (GO:0042402)	2.33062868
98	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.32179305
99	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.30221830
100	reflex (GO:0060004)	2.30178443

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.92823967
2	VDR_22108803_ChIP-Seq_LS180_Human	3.48891030
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.75081487
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.68427920
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.49530010
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.47867092
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.34885650
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.22913532
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.21342881
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.20652604
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.17403393
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14029308
13	EWS_26573619_Chip-Seq_HEK293_Human	2.10072590
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.09660312
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.07491478
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.06773268
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.06678675
18	GBX2_23144817_ChIP-Seq_PC3_Human	2.01936326
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.01799248
20	FUS_26573619_Chip-Seq_HEK293_Human	1.94238235
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.92325259
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.85281639
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.83626970
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.82107321
25	P300_19829295_ChIP-Seq_ESCs_Human	1.80019667
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.76117526
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.65966553
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.64746178
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.61761567
30	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.59740558
31	TAF15_26573619_Chip-Seq_HEK293_Human	1.59588870
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.55382682
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.55282125
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.51720405
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50769298
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.49923332
37	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.49923332
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.48542437
39	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.47003233
40	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.45054777
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.44788364
42	ELK1_19687146_ChIP-ChIP_HELA_Human	1.44415986
43	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.43021018
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39972651
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39972651
46	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.35513861
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34758030
48	AR_20517297_ChIP-Seq_VCAP_Human	1.31712034
49	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.30656249
50	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26404166
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.26404166
52	REST_21632747_ChIP-Seq_MESCs_Mouse	1.24197759
53	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.23181423
54	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22801179
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.22624310
56	AR_21572438_ChIP-Seq_LNCaP_Human	1.20808331
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20418058
58	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.20044029
59	CBP_20019798_ChIP-Seq_JUKART_Human	1.18403034
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18403034
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.18012211
62	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17144706
63	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16387295
64	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.15723268
65	AR_25329375_ChIP-Seq_VCAP_Human	1.15620667
66	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11651303
67	NCOR_22424771_ChIP-Seq_293T_Human	1.11273488
68	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11049071
69	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.10387059
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10210971
71	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.09775063
72	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09558186
73	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09343021
74	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.09234401
75	TCF4_23295773_ChIP-Seq_U87_Human	1.08739195
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08162406
77	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08035162
78	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.07447214
79	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06580771
80	GATA3_26560356_Chip-Seq_TH2_Human	1.05527538
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05060870
82	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04029685
83	STAT3_23295773_ChIP-Seq_U87_Human	1.03579067
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02313815
85	MYC_19829295_ChIP-Seq_ESCs_Human	1.02025296
86	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.01874246
87	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.00531296
88	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.00497760
89	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00225197
90	RUNX2_22187159_ChIP-Seq_PCA_Human	1.00023169
91	ERA_21632823_ChIP-Seq_H3396_Human	0.99482914
92	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.99034316
93	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.98975307
94	FOXP3_21729870_ChIP-Seq_TREG_Human	0.98944804
95	SMAD4_21799915_ChIP-Seq_A2780_Human	0.98903508
96	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.97557638
97	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97408616
98	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.97104698
99	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.96424806
100	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95392937

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.07824976
2	MP0008875_abnormal_xenobiotic_pharmacok	2.92747950
3	MP0008877_abnormal_DNA_methylation	2.89203022
4	MP0006072_abnormal_retinal_apoptosis	2.56895199
5	MP0004147_increased_porphyrin_level	2.37788330
6	MP0005551_abnormal_eye_electrophysiolog	2.24786535
7	MP0000569_abnormal_digit_pigmentation	2.24130821
8	MP0003195_calcinosis	2.18628241
9	MP0006292_abnormal_olfactory_placode	2.10709769
10	MP0004142_abnormal_muscle_tone	2.10265157
11	MP0008872_abnormal_physiological_respon	2.08052114
12	MP0004885_abnormal_endolymph	2.07523549
13	MP0001968_abnormal_touch/_nociception	2.02771422
14	MP0002736_abnormal_nociception_after	2.01410015
15	MP0002876_abnormal_thyroid_physiology	2.00480254
16	MP0005646_abnormal_pituitary_gland	1.99904955
17	MP0002138_abnormal_hepatobiliary_system	1.90780552
18	MP0002837_dystrophic_cardiac_calcinosis	1.89147466
19	MP0002102_abnormal_ear_morphology	1.87779641
20	MP0005671_abnormal_response_to	1.87420988
21	MP0009046_muscle_twitch	1.84251234
22	MP0002638_abnormal_pupillary_reflex	1.83568106
23	MP0005084_abnormal_gallbladder_morpholo	1.83400821
24	MP0002277_abnormal_respiratory_mucosa	1.76793803
25	MP0009745_abnormal_behavioral_response	1.72940294
26	MP0001501_abnormal_sleep_pattern	1.69491429
27	MP0002938_white_spotting	1.68000289
28	MP0005253_abnormal_eye_physiology	1.67368535
29	MP0002653_abnormal_ependyma_morphology	1.61965742
30	MP0000372_irregular_coat_pigmentation	1.61768588
31	MP0003011_delayed_dark_adaptation	1.61137645
32	MP0004133_heterotaxia	1.59815802
33	MP0005645_abnormal_hypothalamus_physiol	1.58864162
34	MP0002272_abnormal_nervous_system	1.57359546
35	MP0001485_abnormal_pinna_reflex	1.54547401
36	MP0009379_abnormal_foot_pigmentation	1.53228991
37	MP0003283_abnormal_digestive_organ	1.50588309
38	MP0004145_abnormal_muscle_electrophysio	1.45064885
39	MP0001529_abnormal_vocalization	1.44120202
40	MP0005174_abnormal_tail_pigmentation	1.43010904
41	MP0000631_abnormal_neuroendocrine_gland	1.42078047
42	MP0004043_abnormal_pH_regulation	1.40643076
43	MP0005075_abnormal_melanosome_morpholog	1.30873162
44	MP0002928_abnormal_bile_duct	1.29322504
45	MP0003878_abnormal_ear_physiology	1.22353337
46	MP0005377_hearing/vestibular/ear_phenot	1.22353337
47	MP0001486_abnormal_startle_reflex	1.20267504
48	MP0001905_abnormal_dopamine_level	1.19551236
49	MP0002064_seizures	1.17156109
50	MP0005389_reproductive_system_phenotype	1.15969077
51	MP0003646_muscle_fatigue	1.14666558
52	MP0002572_abnormal_emotion/affect_behav	1.14232130
53	MP0001986_abnormal_taste_sensitivity	1.14012501
54	MP0001919_abnormal_reproductive_system	1.13618540
55	MP0008058_abnormal_DNA_repair	1.11537993
56	MP0005085_abnormal_gallbladder_physiolo	1.07728902
57	MP0002822_catalepsy	1.04654028
58	MP0002733_abnormal_thermal_nociception	1.04634442
59	MP0001970_abnormal_pain_threshold	1.04534390
60	MP0000685_abnormal_immune_system	1.03429035
61	MP0002751_abnormal_autonomic_nervous	1.02695514
62	MP0002735_abnormal_chemical_nociception	1.02231407
63	MP0003890_abnormal_embryonic-extraembry	1.01359708
64	MP0000427_abnormal_hair_cycle	1.00135024
65	MP0003787_abnormal_imprinting	0.99993083
66	MP0003252_abnormal_bile_duct	0.98297204
67	MP0004742_abnormal_vestibular_system	0.97450249
68	MP0005195_abnormal_posterior_eye	0.96033284
69	MP0002557_abnormal_social/conspecific_i	0.95200962
70	MP0003119_abnormal_digestive_system	0.94670484
71	MP0002160_abnormal_reproductive_system	0.92959696
72	MP0002067_abnormal_sensory_capabilities	0.92427892
73	MP0005167_abnormal_blood-brain_barrier	0.91936105
74	MP0001293_anophthalmia	0.90628176
75	MP0001835_abnormal_antigen_presentation	0.90100707
76	MP0003718_maternal_effect	0.89029083
77	MP0002095_abnormal_skin_pigmentation	0.88862110
78	MP0002693_abnormal_pancreas_physiology	0.88299974
79	MP0002148_abnormal_hypersensitivity_rea	0.87023784
80	MP0005332_abnormal_amino_acid	0.86836291
81	MP0002163_abnormal_gland_morphology	0.83490716
82	MP0008995_early_reproductive_senescence	0.83131881
83	MP0005386_behavior/neurological_phenoty	0.82445515
84	MP0004924_abnormal_behavior	0.82445515
85	MP0002234_abnormal_pharynx_morphology	0.81432833
86	MP0005410_abnormal_fertilization	0.79369997
87	MP0000026_abnormal_inner_ear	0.77905957
88	MP0004215_abnormal_myocardial_fiber	0.77028396
89	MP0001984_abnormal_olfaction	0.76510993
90	MP0005379_endocrine/exocrine_gland_phen	0.76132944
91	MP0006036_abnormal_mitochondrial_physio	0.75812387
92	MP0006276_abnormal_autonomic_nervous	0.75285947
93	MP0002752_abnormal_somatic_nervous	0.75051093
94	MP0002909_abnormal_adrenal_gland	0.74496451
95	MP0000230_abnormal_systemic_arterial	0.74342544
96	MP0005365_abnormal_bile_salt	0.73854415
97	MP0001800_abnormal_humoral_immune	0.73528735
98	MP0001502_abnormal_circadian_rhythm	0.73092702
99	MP0003786_premature_aging	0.72403624
100	MP0001764_abnormal_homeostasis	0.71146107

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.54987918
2	Pancreatic cysts (HP:0001737)	4.12751406
3	Congenital, generalized hypertrichosis (HP:0004540)	3.91001676
4	Pancreatic fibrosis (HP:0100732)	3.88572924
5	Abnormality of midbrain morphology (HP:0002418)	3.63793674
6	Molar tooth sign on MRI (HP:0002419)	3.63793674
7	True hermaphroditism (HP:0010459)	3.59229337
8	Type II lissencephaly (HP:0007260)	3.36517182
9	Nephronophthisis (HP:0000090)	3.34756970
10	Mitochondrial inheritance (HP:0001427)	3.11324819
11	Acute necrotizing encephalopathy (HP:0006965)	3.07858426
12	Increased CSF lactate (HP:0002490)	3.00739978
13	Abnormality of the renal cortex (HP:0011035)	2.93170447
14	Increased hepatocellular lipid droplets (HP:0006565)	2.78895707
15	Abolished electroretinogram (ERG) (HP:0000550)	2.77996105
16	Lipid accumulation in hepatocytes (HP:0006561)	2.76914220
17	Abnormality of the renal medulla (HP:0100957)	2.75925326
18	Large for gestational age (HP:0001520)	2.70118077
19	Acute encephalopathy (HP:0006846)	2.68185542
20	Progressive macrocephaly (HP:0004481)	2.67541495
21	Renal cortical cysts (HP:0000803)	2.64259260
22	Attenuation of retinal blood vessels (HP:0007843)	2.59550329
23	Abnormal mitochondria in muscle tissue (HP:0008316)	2.59216415
24	IgG deficiency (HP:0004315)	2.54769356
25	Hepatocellular necrosis (HP:0001404)	2.50971346
26	Abnormality of the pons (HP:0007361)	2.50063779
27	3-Methylglutaconic aciduria (HP:0003535)	2.49926860
28	Pendular nystagmus (HP:0012043)	2.47340178
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.45889506
30	Sclerocornea (HP:0000647)	2.40371916
31	Hypoplasia of the pons (HP:0012110)	2.39690185
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.39141492
33	Absent/shortened dynein arms (HP:0200106)	2.39141492
34	Cystic liver disease (HP:0006706)	2.38310151
35	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.35794417
36	Abnormality of alanine metabolism (HP:0010916)	2.35794417
37	Hyperalaninemia (HP:0003348)	2.35794417
38	Concave nail (HP:0001598)	2.35322995
39	Hepatic necrosis (HP:0002605)	2.33800383
40	Optic disc pallor (HP:0000543)	2.31939920
41	Abnormal drinking behavior (HP:0030082)	2.31685178
42	Polydipsia (HP:0001959)	2.31685178
43	Tubular atrophy (HP:0000092)	2.28732182
44	Abnormal respiratory motile cilium morphology (HP:0005938)	2.26660415
45	Abnormal respiratory epithelium morphology (HP:0012253)	2.26660415
46	Inability to walk (HP:0002540)	2.25010824
47	Chronic hepatic failure (HP:0100626)	2.22296116
48	Aplasia/hypoplasia of the uterus (HP:0008684)	2.21520245
49	Medial flaring of the eyebrow (HP:0010747)	2.20099897
50	Bile duct proliferation (HP:0001408)	2.18344996
51	Abnormal biliary tract physiology (HP:0012439)	2.18344996
52	Methylmalonic acidemia (HP:0002912)	2.18042755
53	Type 2 muscle fiber atrophy (HP:0003554)	2.15138019
54	Methylmalonic aciduria (HP:0012120)	2.10665550
55	Abnormal number of erythroid precursors (HP:0012131)	2.10304115
56	Abnormality of B cell number (HP:0010975)	2.09184469
57	Bilateral microphthalmos (HP:0007633)	2.07215799
58	Abnormal ciliary motility (HP:0012262)	2.05399078
59	Anencephaly (HP:0002323)	2.03623446
60	Stomatitis (HP:0010280)	2.03456463
61	Furrowed tongue (HP:0000221)	2.02388006
62	Cerebellar dysplasia (HP:0007033)	2.00676262
63	Keratoconus (HP:0000563)	1.99784946
64	Increased corneal curvature (HP:0100692)	1.99784946
65	Rib fusion (HP:0000902)	1.97928025
66	Focal motor seizures (HP:0011153)	1.97912817
67	Chorioretinal atrophy (HP:0000533)	1.96127778
68	Renal Fanconi syndrome (HP:0001994)	1.96040312
69	Increased serum lactate (HP:0002151)	1.94872805
70	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.94845774
71	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.93723096
72	Hyperventilation (HP:0002883)	1.93035623
73	Thyroiditis (HP:0100646)	1.92385273
74	Progressive cerebellar ataxia (HP:0002073)	1.91994395
75	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.91832935
76	Polyuria (HP:0000103)	1.89714332
77	B lymphocytopenia (HP:0010976)	1.89559677
78	Abnormal respiratory motile cilium physiology (HP:0012261)	1.87657547
79	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.86784697
80	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.86655692
81	Hypothermia (HP:0002045)	1.86279834
82	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.85782136
83	Optic nerve hypoplasia (HP:0000609)	1.83997459
84	Delayed CNS myelination (HP:0002188)	1.83659969
85	Abnormality of the renal collecting system (HP:0004742)	1.82489556
86	Severe muscular hypotonia (HP:0006829)	1.82488441
87	Cerebral edema (HP:0002181)	1.81849185
88	Duplicated collecting system (HP:0000081)	1.81119439
89	Exertional dyspnea (HP:0002875)	1.79733598
90	Congenital hepatic fibrosis (HP:0002612)	1.79651949
91	Progressive inability to walk (HP:0002505)	1.79519282
92	Male pseudohermaphroditism (HP:0000037)	1.76866602
93	Lissencephaly (HP:0001339)	1.76854088
94	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.76516362
95	Asplenia (HP:0001746)	1.75391534
96	Hypoproteinemia (HP:0003075)	1.75037034
97	Abnormality of cells of the erythroid lineage (HP:0012130)	1.74200217
98	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.73769396
99	Severe combined immunodeficiency (HP:0004430)	1.73248261
100	Short tibia (HP:0005736)	1.72281083

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.45403709
2	TLK1	3.43772985
3	ADRBK2	3.34076088
4	ZAK	3.27878138
5	TXK	2.98522624
6	BMPR1B	2.83359707
7	MAP4K2	2.80294253
8	PNCK	2.76138662
9	GRK1	2.75390872
10	WNK4	2.65155229
11	MAPK15	2.23928484
12	TAOK3	2.07085369
13	NUAK1	2.05974708
14	ACVR1B	2.04984141
15	TSSK6	2.01798145
16	WNK3	1.83057660
17	TIE1	1.76664227
18	DAPK2	1.76209142
19	PINK1	1.54659144
20	OXSR1	1.47783335
21	MKNK2	1.45811651
22	INSRR	1.45730096
23	NME1	1.45659363
24	MAPK13	1.40863862
25	BCKDK	1.39776465
26	VRK1	1.39321998
27	MST4	1.38637793
28	TAF1	1.35588649
29	STK39	1.34055266
30	TGFBR1	1.26542607
31	PHKG2	1.21534045
32	PHKG1	1.21534045
33	EIF2AK3	1.17140922
34	ADRBK1	1.14644032
35	CASK	1.14147751
36	WEE1	1.11624670
37	MKNK1	1.03253959
38	DYRK2	1.02268258
39	MAPKAPK3	0.97990703
40	CAMKK2	0.96527804
41	VRK2	0.94544944
42	MAP3K4	0.86335017
43	IKBKB	0.84093400
44	NTRK2	0.82778777
45	KIT	0.81444259
46	PRKCG	0.79724874
47	STK38L	0.78206536
48	PLK3	0.76324865
49	TNIK	0.74504743
50	TEC	0.74276501
51	SRPK1	0.71931338
52	MAP2K2	0.71833164
53	NTRK3	0.70337655
54	RPS6KA5	0.68619692
55	FES	0.67629385
56	ITK	0.67527319
57	MAP4K1	0.65264961
58	GRK7	0.64700173
59	MAPKAPK5	0.64566951
60	IKBKE	0.62930223
61	PRKCQ	0.62485534
62	PASK	0.60720529
63	MAP2K6	0.59605384
64	PRKCE	0.58750201
65	PAK3	0.56636292
66	PRKCI	0.55687642
67	SYK	0.52178023
68	CHUK	0.51059810
69	CSNK1G1	0.48532501
70	EIF2AK2	0.48460163
71	CDC7	0.47899103
72	EIF2AK1	0.46441946
73	STK11	0.46159399
74	CAMK1	0.45712315
75	CSNK1G2	0.45430943
76	PIK3CA	0.45022126
77	PKN1	0.40432875
78	CSNK1G3	0.39804616
79	CDK8	0.39638278
80	OBSCN	0.39387768
81	PRKACA	0.39047707
82	FGFR2	0.38918158
83	WNK1	0.38259141
84	LCK	0.38132311
85	CAMK2A	0.37123896
86	GRK5	0.36763156
87	LYN	0.36353422
88	IGF1R	0.34572343
89	IRAK1	0.33775790
90	PLK2	0.32348313
91	MUSK	0.32178706
92	PTK2B	0.32140711
93	PRKCA	0.31984035
94	PLK4	0.31687731
95	NEK2	0.31230691
96	GRK6	0.29993411
97	FLT3	0.29690914
98	CDK3	0.28566076
99	CSF1R	0.27794764
100	IRAK4	0.27614029

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.13379516
2	Caffeine metabolism_Homo sapiens_hsa00232	2.86080405
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.51451126
4	Phototransduction_Homo sapiens_hsa04744	2.48243964
5	Proteasome_Homo sapiens_hsa03050	2.45003528
6	Parkinsons disease_Homo sapiens_hsa05012	2.43690144
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.42644667
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.37558101
9	Protein export_Homo sapiens_hsa03060	2.30621810
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.22843919
11	RNA polymerase_Homo sapiens_hsa03020	2.20103829
12	Ribosome_Homo sapiens_hsa03010	2.04125827
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.98283909
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.93183989
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.89064216
16	Homologous recombination_Homo sapiens_hsa03440	1.74903127
17	Asthma_Homo sapiens_hsa05310	1.71762004
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.69478096
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.62059658
20	Alzheimers disease_Homo sapiens_hsa05010	1.60514534
21	Basal transcription factors_Homo sapiens_hsa03022	1.57816884
22	Huntingtons disease_Homo sapiens_hsa05016	1.57770475
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.56934594
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.56311583
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.51014199
26	Butanoate metabolism_Homo sapiens_hsa00650	1.49749795
27	Primary immunodeficiency_Homo sapiens_hsa05340	1.47755389
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.47402417
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.45389314
30	RNA degradation_Homo sapiens_hsa03018	1.44151125
31	Nicotine addiction_Homo sapiens_hsa05033	1.43850141
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.36706254
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.34905673
34	One carbon pool by folate_Homo sapiens_hsa00670	1.34772240
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.29913039
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.28832931
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.28717135
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.27452337
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.24595495
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.21699604
41	Type I diabetes mellitus_Homo sapiens_hsa04940	1.18175718
42	Allograft rejection_Homo sapiens_hsa05330	1.14910870
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.10733701
44	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.09583214
45	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.09083073
46	Chemical carcinogenesis_Homo sapiens_hsa05204	1.08633763
47	Propanoate metabolism_Homo sapiens_hsa00640	1.05439647
48	Peroxisome_Homo sapiens_hsa04146	0.99151372
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.98622177
50	Graft-versus-host disease_Homo sapiens_hsa05332	0.96257975
51	Olfactory transduction_Homo sapiens_hsa04740	0.95793786
52	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.95511175
53	Retinol metabolism_Homo sapiens_hsa00830	0.93017484
54	Taste transduction_Homo sapiens_hsa04742	0.92226335
55	Purine metabolism_Homo sapiens_hsa00230	0.86107630
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.85871718
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.85269196
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.85157162
59	Sulfur metabolism_Homo sapiens_hsa00920	0.84357873
60	Morphine addiction_Homo sapiens_hsa05032	0.80689189
61	Sulfur relay system_Homo sapiens_hsa04122	0.78789687
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.75512008
63	ABC transporters_Homo sapiens_hsa02010	0.73619838
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71363957
65	Antigen processing and presentation_Homo sapiens_hsa04612	0.70792126
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.69499538
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68081349
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65757578
69	Rheumatoid arthritis_Homo sapiens_hsa05323	0.65230099
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.65091281
71	Insulin secretion_Homo sapiens_hsa04911	0.62376160
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61964295
73	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.59657189
74	Serotonergic synapse_Homo sapiens_hsa04726	0.59518468
75	Metabolic pathways_Homo sapiens_hsa01100	0.57459518
76	GABAergic synapse_Homo sapiens_hsa04727	0.57108920
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55075687
78	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52819244
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51417550
80	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.49683315
81	Circadian entrainment_Homo sapiens_hsa04713	0.49203626
82	Glutamatergic synapse_Homo sapiens_hsa04724	0.48570508
83	Salivary secretion_Homo sapiens_hsa04970	0.47178098
84	Regulation of autophagy_Homo sapiens_hsa04140	0.46885794
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44325531
86	Mismatch repair_Homo sapiens_hsa03430	0.42335435
87	Mineral absorption_Homo sapiens_hsa04978	0.40345924
88	Histidine metabolism_Homo sapiens_hsa00340	0.39570358
89	Calcium signaling pathway_Homo sapiens_hsa04020	0.39549077
90	Spliceosome_Homo sapiens_hsa03040	0.38238758
91	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.37986805
92	Folate biosynthesis_Homo sapiens_hsa00790	0.35857537
93	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.34505496
94	Steroid biosynthesis_Homo sapiens_hsa00100	0.34241525
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.34089018
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.33353676
97	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.32515403
98	RNA transport_Homo sapiens_hsa03013	0.32367214
99	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.31721893
100	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.30747172

HSPD1P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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