

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of isotype switching to IgG isotypes (GO:0048302) | 5.39216752 |
| 2 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 5.34240454 |
| 3 | proteasome assembly (GO:0043248) | 5.31058859 |
| 4 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.92315578 |
| 5 | maturation of 5.8S rRNA (GO:0000460) | 4.66055547 |
| 6 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 4.64526475 |
| 7 | chaperone-mediated protein transport (GO:0072321) | 4.53612152 |
| 8 | DNA deamination (GO:0045006) | 4.51898625 |
| 9 | positive regulation of isotype switching (GO:0045830) | 4.38837175 |
| 10 | regulation of immunoglobulin secretion (GO:0051023) | 4.28240076 |
| 11 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.23399279 |
| 12 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.14369045 |
| 13 | positive regulation of DNA recombination (GO:0045911) | 4.10854043 |
| 14 | ribosome assembly (GO:0042255) | 3.97836188 |
| 15 | IMP biosynthetic process (GO:0006188) | 3.95343861 |
| 16 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.93506731 |
| 17 | regulation of chronic inflammatory response (GO:0002676) | 3.90112342 |
| 18 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.88526759 |
| 19 | NADH dehydrogenase complex assembly (GO:0010257) | 3.86360628 |
| 20 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.86360628 |
| 21 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.86360628 |
| 22 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.85995522 |
| 23 | GTP biosynthetic process (GO:0006183) | 3.85354984 |
| 24 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.84260857 |
| 25 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.83695454 |
| 26 | negative regulation of ligase activity (GO:0051352) | 3.83528286 |
| 27 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.83528286 |
| 28 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.73931813 |
| 29 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.73931813 |
| 30 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.67649029 |
| 31 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.65409298 |
| 32 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.65409298 |
| 33 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.65409298 |
| 34 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.60120917 |
| 35 | rRNA modification (GO:0000154) | 3.59994929 |
| 36 | ATP synthesis coupled proton transport (GO:0015986) | 3.59868571 |
| 37 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.59868571 |
| 38 | protein complex biogenesis (GO:0070271) | 3.59622823 |
| 39 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.59583491 |
| 40 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.59583491 |
| 41 | protein neddylation (GO:0045116) | 3.54269865 |
| 42 | UTP biosynthetic process (GO:0006228) | 3.52888793 |
| 43 | regulation of regulatory T cell differentiation (GO:0045589) | 3.52670889 |
| 44 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.52595897 |
| 45 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.52595897 |
| 46 | maturation of SSU-rRNA (GO:0030490) | 3.51124617 |
| 47 | rRNA methylation (GO:0031167) | 3.49032043 |
| 48 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.48744193 |
| 49 | viral mRNA export from host cell nucleus (GO:0046784) | 3.48431638 |
| 50 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.45455732 |
| 51 | rRNA processing (GO:0006364) | 3.42819652 |
| 52 | termination of RNA polymerase I transcription (GO:0006363) | 3.42314520 |
| 53 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.41714260 |
| 54 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.41697776 |
| 55 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.39091888 |
| 56 | nucleobase biosynthetic process (GO:0046112) | 3.36891517 |
| 57 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.32870089 |
| 58 | positive regulation of B cell mediated immunity (GO:0002714) | 3.32870089 |
| 59 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.32700540 |
| 60 | rRNA metabolic process (GO:0016072) | 3.30631880 |
| 61 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.26840199 |
| 62 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.26656500 |
| 63 | ribosome biogenesis (GO:0042254) | 3.22758132 |
| 64 | respiratory chain complex IV assembly (GO:0008535) | 3.21612784 |
| 65 | spliceosomal snRNP assembly (GO:0000387) | 3.18725435 |
| 66 | pseudouridine synthesis (GO:0001522) | 3.15817365 |
| 67 | IMP metabolic process (GO:0046040) | 3.15668214 |
| 68 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.13372370 |
| 69 | positive regulation of ligase activity (GO:0051351) | 3.12115092 |
| 70 | histone mRNA metabolic process (GO:0008334) | 3.10675715 |
| 71 | regulation of podosome assembly (GO:0071801) | 3.10234625 |
| 72 | regulation of isotype switching (GO:0045191) | 3.09941573 |
| 73 | peptidyl-histidine modification (GO:0018202) | 3.09404241 |
| 74 | intracellular protein transmembrane import (GO:0044743) | 3.09284971 |
| 75 | regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339 | 3.07593445 |
| 76 | UTP metabolic process (GO:0046051) | 3.07494141 |
| 77 | DNA replication checkpoint (GO:0000076) | 3.03472647 |
| 78 | protein K6-linked ubiquitination (GO:0085020) | 3.03061778 |
| 79 | ribosomal large subunit biogenesis (GO:0042273) | 3.01731406 |
| 80 | tRNA aminoacylation (GO:0043039) | 3.00940056 |
| 81 | amino acid activation (GO:0043038) | 3.00940056 |
| 82 | positive regulation of immunoglobulin production (GO:0002639) | 2.99178390 |
| 83 | tRNA aminoacylation for protein translation (GO:0006418) | 2.98827347 |
| 84 | 7-methylguanosine mRNA capping (GO:0006370) | 2.98360846 |
| 85 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.97799581 |
| 86 | chromatin remodeling at centromere (GO:0031055) | 2.96475465 |
| 87 | CENP-A containing nucleosome assembly (GO:0034080) | 2.95909434 |
| 88 | tRNA processing (GO:0008033) | 2.93792303 |
| 89 | tRNA metabolic process (GO:0006399) | 2.92932889 |
| 90 | purine nucleobase biosynthetic process (GO:0009113) | 2.92257978 |
| 91 | replication fork processing (GO:0031297) | 2.91246897 |
| 92 | 7-methylguanosine RNA capping (GO:0009452) | 2.91017992 |
| 93 | RNA capping (GO:0036260) | 2.91017992 |
| 94 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.88799764 |
| 95 | isotype switching (GO:0045190) | 2.88799764 |
| 96 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.88799764 |
| 97 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.88069437 |
| 98 | ncRNA metabolic process (GO:0034660) | 2.87274815 |
| 99 | termination of RNA polymerase III transcription (GO:0006386) | 2.86942011 |
| 100 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.86942011 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.62020373 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.74822099 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.30309302 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.63151416 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.37599182 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.33442382 |
| 7 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.14243834 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.09341445 |
| 9 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.05495441 |
| 10 | VDR_23849224_ChIP-Seq_CD4+_Human | 3.04952271 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.97853711 |
| 12 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.97654315 |
| 13 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.72828965 |
| 14 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.46160039 |
| 15 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.45462824 |
| 16 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.44830011 |
| 17 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.32411368 |
| 18 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.25754616 |
| 19 | VDR_22108803_ChIP-Seq_LS180_Human | 2.25063880 |
| 20 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.18923905 |
| 21 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.17889461 |
| 22 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.16434413 |
| 23 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 2.14906756 |
| 24 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.14597132 |
| 25 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.13434085 |
| 26 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.13394278 |
| 27 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.99605235 |
| 28 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.96735885 |
| 29 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.95456578 |
| 30 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.95274485 |
| 31 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.92501140 |
| 32 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.86954864 |
| 33 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.85151360 |
| 34 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.83505365 |
| 35 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.81474554 |
| 36 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.79385300 |
| 37 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.79076262 |
| 38 | EWS_26573619_Chip-Seq_HEK293_Human | 1.78542965 |
| 39 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.76666286 |
| 40 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.75879836 |
| 41 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.72036125 |
| 42 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.71281315 |
| 43 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.66511946 |
| 44 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.64169833 |
| 45 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.59913368 |
| 46 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.58462370 |
| 47 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.58140384 |
| 48 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.56185424 |
| 49 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.54452717 |
| 50 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.52959328 |
| 51 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.51753836 |
| 52 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.50462161 |
| 53 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.50412197 |
| 54 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.43630463 |
| 55 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.38661412 |
| 56 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.35307532 |
| 57 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.34838073 |
| 58 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.22107683 |
| 59 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.17318553 |
| 60 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.17166701 |
| 61 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.16410275 |
| 62 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.15177256 |
| 63 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.14795250 |
| 64 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.13585522 |
| 65 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.12230962 |
| 66 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.11888155 |
| 67 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.09730755 |
| 68 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.08688733 |
| 69 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.07852210 |
| 70 | GATA1_22025678_ChIP-Seq_K562_Human | 1.03560066 |
| 71 | FUS_26573619_Chip-Seq_HEK293_Human | 0.97251327 |
| 72 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.96984456 |
| 73 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.96851421 |
| 74 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.96064759 |
| 75 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.95960614 |
| 76 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.95960614 |
| 77 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.95444405 |
| 78 | P300_19829295_ChIP-Seq_ESCs_Human | 0.95304690 |
| 79 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.94478713 |
| 80 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.93900624 |
| 81 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.93274637 |
| 82 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.93274637 |
| 83 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.91474059 |
| 84 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.90876081 |
| 85 | GATA3_26560356_Chip-Seq_TH2_Human | 0.90462921 |
| 86 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.89739878 |
| 87 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.86654977 |
| 88 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.85092003 |
| 89 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.84836397 |
| 90 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.84445875 |
| 91 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.84247094 |
| 92 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.84000298 |
| 93 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.83958934 |
| 94 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.81376767 |
| 95 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.80462199 |
| 96 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.79637053 |
| 97 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.78797908 |
| 98 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.78387640 |
| 99 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.77243624 |
| 100 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.77040562 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 4.07102722 |
| 2 | MP0001835_abnormal_antigen_presentation | 3.60670625 |
| 3 | MP0001873_stomach_inflammation | 3.55316333 |
| 4 | MP0003693_abnormal_embryo_hatching | 3.23609587 |
| 5 | MP0002138_abnormal_hepatobiliary_system | 3.05866349 |
| 6 | MP0005671_abnormal_response_to | 2.87466578 |
| 7 | MP0004957_abnormal_blastocyst_morpholog | 2.85343344 |
| 8 | MP0008057_abnormal_DNA_replication | 2.59103902 |
| 9 | MP0003195_calcinosis | 2.54772401 |
| 10 | MP0001853_heart_inflammation | 2.42788603 |
| 11 | MP0003806_abnormal_nucleotide_metabolis | 2.41140148 |
| 12 | MP0010094_abnormal_chromosome_stability | 2.30416697 |
| 13 | MP0008875_abnormal_xenobiotic_pharmacok | 2.14151557 |
| 14 | MP0003718_maternal_effect | 2.13084095 |
| 15 | MP0008872_abnormal_physiological_respon | 2.04905308 |
| 16 | MP0002006_tumorigenesis | 2.00731395 |
| 17 | MP0009333_abnormal_splenocyte_physiolog | 1.98039354 |
| 18 | MP0003890_abnormal_embryonic-extraembry | 1.96138431 |
| 19 | MP0005084_abnormal_gallbladder_morpholo | 1.93954179 |
| 20 | MP0002938_white_spotting | 1.91991461 |
| 21 | MP0000685_abnormal_immune_system | 1.89715898 |
| 22 | MP0005387_immune_system_phenotype | 1.89212914 |
| 23 | MP0001790_abnormal_immune_system | 1.89212914 |
| 24 | MP0003786_premature_aging | 1.86377163 |
| 25 | MP0001348_abnormal_lacrimal_gland | 1.79752149 |
| 26 | MP0006072_abnormal_retinal_apoptosis | 1.77099885 |
| 27 | MP0005408_hypopigmentation | 1.74007456 |
| 28 | MP0002102_abnormal_ear_morphology | 1.73606691 |
| 29 | MP0009785_altered_susceptibility_to | 1.72984113 |
| 30 | MP0003077_abnormal_cell_cycle | 1.72706066 |
| 31 | MP0002148_abnormal_hypersensitivity_rea | 1.68699632 |
| 32 | MP0003186_abnormal_redox_activity | 1.68657153 |
| 33 | MP0002166_altered_tumor_susceptibility | 1.67778576 |
| 34 | MP0001529_abnormal_vocalization | 1.61012678 |
| 35 | MP0002163_abnormal_gland_morphology | 1.57484973 |
| 36 | MP0003111_abnormal_nucleus_morphology | 1.57089700 |
| 37 | MP0003878_abnormal_ear_physiology | 1.52278322 |
| 38 | MP0005377_hearing/vestibular/ear_phenot | 1.52278322 |
| 39 | MP0001881_abnormal_mammary_gland | 1.46370096 |
| 40 | MP0001800_abnormal_humoral_immune | 1.45809013 |
| 41 | MP0004147_increased_porphyrin_level | 1.44778877 |
| 42 | MP0001968_abnormal_touch/_nociception | 1.43280591 |
| 43 | MP0000372_irregular_coat_pigmentation | 1.42902265 |
| 44 | MP0008007_abnormal_cellular_replicative | 1.37749199 |
| 45 | MP0009697_abnormal_copulation | 1.35925636 |
| 46 | MP0002736_abnormal_nociception_after | 1.33341223 |
| 47 | MP0002405_respiratory_system_inflammati | 1.32473643 |
| 48 | MP0001501_abnormal_sleep_pattern | 1.30601012 |
| 49 | MP0006292_abnormal_olfactory_placode | 1.22226277 |
| 50 | MP0006036_abnormal_mitochondrial_physio | 1.12839053 |
| 51 | MP0006082_CNS_inflammation | 1.08217256 |
| 52 | MP0003300_gastrointestinal_ulcer | 1.05992061 |
| 53 | MP0001984_abnormal_olfaction | 1.05074556 |
| 54 | MP0004782_abnormal_surfactant_physiolog | 1.04576224 |
| 55 | MP0004142_abnormal_muscle_tone | 1.02984836 |
| 56 | MP0005075_abnormal_melanosome_morpholog | 1.02720801 |
| 57 | MP0008877_abnormal_DNA_methylation | 1.02675823 |
| 58 | MP0003936_abnormal_reproductive_system | 1.01698383 |
| 59 | MP0002837_dystrophic_cardiac_calcinosis | 1.01215971 |
| 60 | MP0003567_abnormal_fetal_cardiomyocyte | 1.00843594 |
| 61 | MP0005000_abnormal_immune_tolerance | 0.99167533 |
| 62 | MP0004145_abnormal_muscle_electrophysio | 0.98729089 |
| 63 | MP0008932_abnormal_embryonic_tissue | 0.94092161 |
| 64 | MP0003950_abnormal_plasma_membrane | 0.93699718 |
| 65 | MP0002723_abnormal_immune_serum | 0.93230217 |
| 66 | MP0004885_abnormal_endolymph | 0.89081819 |
| 67 | MP0002822_catalepsy | 0.87266447 |
| 68 | MP0002210_abnormal_sex_determination | 0.85982180 |
| 69 | MP0005551_abnormal_eye_electrophysiolog | 0.85039883 |
| 70 | MP0001905_abnormal_dopamine_level | 0.83958704 |
| 71 | MP0003436_decreased_susceptibility_to | 0.79718256 |
| 72 | MP0005379_endocrine/exocrine_gland_phen | 0.77725384 |
| 73 | MP0000627_abnormal_mammary_gland | 0.76507135 |
| 74 | MP0002751_abnormal_autonomic_nervous | 0.76160335 |
| 75 | MP0001764_abnormal_homeostasis | 0.75722295 |
| 76 | MP0001845_abnormal_inflammatory_respons | 0.75481091 |
| 77 | MP0003763_abnormal_thymus_physiology | 0.74986744 |
| 78 | MP0005636_abnormal_mineral_homeostasis | 0.74978267 |
| 79 | MP0005253_abnormal_eye_physiology | 0.74680678 |
| 80 | MP0005645_abnormal_hypothalamus_physiol | 0.73799907 |
| 81 | MP0002693_abnormal_pancreas_physiology | 0.73436258 |
| 82 | MP0000689_abnormal_spleen_morphology | 0.73039872 |
| 83 | MP0004742_abnormal_vestibular_system | 0.72345895 |
| 84 | MP0002420_abnormal_adaptive_immunity | 0.72092283 |
| 85 | MP0001663_abnormal_digestive_system | 0.71500630 |
| 86 | MP0002019_abnormal_tumor_incidence | 0.71443256 |
| 87 | MP0003137_abnormal_impulse_conducting | 0.71176590 |
| 88 | MP0010155_abnormal_intestine_physiology | 0.70966666 |
| 89 | MP0001188_hyperpigmentation | 0.69804970 |
| 90 | MP0002452_abnormal_antigen_presenting | 0.68886097 |
| 91 | MP0002277_abnormal_respiratory_mucosa | 0.68259815 |
| 92 | MP0000631_abnormal_neuroendocrine_gland | 0.68207984 |
| 93 | MP0001819_abnormal_immune_cell | 0.66712135 |
| 94 | MP0006035_abnormal_mitochondrial_morpho | 0.65786835 |
| 95 | MP0001293_anophthalmia | 0.65637506 |
| 96 | MP0004215_abnormal_myocardial_fiber | 0.63879026 |
| 97 | MP0000703_abnormal_thymus_morphology | 0.63556597 |
| 98 | MP0001730_embryonic_growth_arrest | 0.62694699 |
| 99 | MP0010030_abnormal_orbit_morphology | 0.61539762 |
| 100 | MP0000613_abnormal_salivary_gland | 0.61151642 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.73112537 |
| 2 | Acute encephalopathy (HP:0006846) | 4.18668877 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.10832448 |
| 4 | Mitochondrial inheritance (HP:0001427) | 3.99621015 |
| 5 | Progressive macrocephaly (HP:0004481) | 3.93735528 |
| 6 | Increased CSF lactate (HP:0002490) | 3.93618657 |
| 7 | Abnormality of the pons (HP:0007361) | 3.62085471 |
| 8 | Stomatitis (HP:0010280) | 3.53147138 |
| 9 | Hepatocellular necrosis (HP:0001404) | 3.44932277 |
| 10 | Hypoproteinemia (HP:0003075) | 3.42176339 |
| 11 | Hepatic necrosis (HP:0002605) | 3.33892914 |
| 12 | Increased hepatocellular lipid droplets (HP:0006565) | 3.32947100 |
| 13 | Pancreatic cysts (HP:0001737) | 3.24644533 |
| 14 | 3-Methylglutaconic aciduria (HP:0003535) | 3.24347648 |
| 15 | Methylmalonic acidemia (HP:0002912) | 3.23474372 |
| 16 | IgG deficiency (HP:0004315) | 3.04777299 |
| 17 | Cerebral edema (HP:0002181) | 3.04537378 |
| 18 | Reduced antithrombin III activity (HP:0001976) | 3.03286305 |
| 19 | Molar tooth sign on MRI (HP:0002419) | 3.02274307 |
| 20 | Abnormality of midbrain morphology (HP:0002418) | 3.02274307 |
| 21 | Hypoplasia of the pons (HP:0012110) | 3.01101110 |
| 22 | Lipid accumulation in hepatocytes (HP:0006561) | 2.97023461 |
| 23 | Increased serum pyruvate (HP:0003542) | 2.90604391 |
| 24 | Increased serum lactate (HP:0002151) | 2.86873273 |
| 25 | Optic disc pallor (HP:0000543) | 2.85149503 |
| 26 | Type I transferrin isoform profile (HP:0003642) | 2.84035564 |
| 27 | Congenital, generalized hypertrichosis (HP:0004540) | 2.70315720 |
| 28 | Oral leukoplakia (HP:0002745) | 2.68737806 |
| 29 | Leukodystrophy (HP:0002415) | 2.66398200 |
| 30 | Exercise intolerance (HP:0003546) | 2.66048437 |
| 31 | Methylmalonic aciduria (HP:0012120) | 2.66032963 |
| 32 | Abnormality of glycolysis (HP:0004366) | 2.65529642 |
| 33 | Abnormality of the renal cortex (HP:0011035) | 2.65229402 |
| 34 | Meckel diverticulum (HP:0002245) | 2.64246767 |
| 35 | Abnormality of the ileum (HP:0001549) | 2.60000383 |
| 36 | Abnormality of the labia minora (HP:0012880) | 2.55767471 |
| 37 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 2.52799093 |
| 38 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.46940171 |
| 39 | Renal cortical cysts (HP:0000803) | 2.46764527 |
| 40 | Respiratory failure (HP:0002878) | 2.40502939 |
| 41 | Duplicated collecting system (HP:0000081) | 2.38876989 |
| 42 | Abnormality of alanine metabolism (HP:0010916) | 2.36391696 |
| 43 | Hyperalaninemia (HP:0003348) | 2.36391696 |
| 44 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.36391696 |
| 45 | Pancreatic fibrosis (HP:0100732) | 2.35257556 |
| 46 | Progressive inability to walk (HP:0002505) | 2.34514086 |
| 47 | Abnormality of the preputium (HP:0100587) | 2.33495463 |
| 48 | Nephronophthisis (HP:0000090) | 2.31417590 |
| 49 | Lactic acidosis (HP:0003128) | 2.29726949 |
| 50 | Testicular atrophy (HP:0000029) | 2.25965062 |
| 51 | Increased IgM level (HP:0003496) | 2.24940684 |
| 52 | Abnormality of the anterior horn cell (HP:0006802) | 2.24421188 |
| 53 | Degeneration of anterior horn cells (HP:0002398) | 2.24421188 |
| 54 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.22628474 |
| 55 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.22506286 |
| 56 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.22506286 |
| 57 | Colon cancer (HP:0003003) | 2.21214372 |
| 58 | Tubular atrophy (HP:0000092) | 2.20734405 |
| 59 | Microvesicular hepatic steatosis (HP:0001414) | 2.19045453 |
| 60 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.17650284 |
| 61 | Renal Fanconi syndrome (HP:0001994) | 2.15354023 |
| 62 | Abnormality of the renal collecting system (HP:0004742) | 2.13951531 |
| 63 | Lethargy (HP:0001254) | 2.11294353 |
| 64 | Constricted visual fields (HP:0001133) | 2.09784043 |
| 65 | Abolished electroretinogram (ERG) (HP:0000550) | 2.08933023 |
| 66 | Inability to walk (HP:0002540) | 2.08228910 |
| 67 | Pancytopenia (HP:0001876) | 2.07780037 |
| 68 | Chromsome breakage (HP:0040012) | 2.04590925 |
| 69 | Bile duct proliferation (HP:0001408) | 2.03372185 |
| 70 | Abnormal biliary tract physiology (HP:0012439) | 2.03372185 |
| 71 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.00726118 |
| 72 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.00726118 |
| 73 | Abnormal protein glycosylation (HP:0012346) | 2.00726118 |
| 74 | Abnormal glycosylation (HP:0012345) | 2.00726118 |
| 75 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.00617201 |
| 76 | Exertional dyspnea (HP:0002875) | 2.00313895 |
| 77 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.98532581 |
| 78 | CNS demyelination (HP:0007305) | 1.92820173 |
| 79 | Abnormality of the renal medulla (HP:0100957) | 1.91716314 |
| 80 | Pendular nystagmus (HP:0012043) | 1.91707235 |
| 81 | Abnormality of chromosome stability (HP:0003220) | 1.91214140 |
| 82 | Abnormality of DNA repair (HP:0003254) | 1.88256134 |
| 83 | Increased intramyocellular lipid droplets (HP:0012240) | 1.87877428 |
| 84 | Amniotic constriction ring (HP:0009775) | 1.86565087 |
| 85 | Abnormality of placental membranes (HP:0011409) | 1.86565087 |
| 86 | Nausea (HP:0002018) | 1.86460817 |
| 87 | Carpal bone hypoplasia (HP:0001498) | 1.85923362 |
| 88 | Delayed CNS myelination (HP:0002188) | 1.84459282 |
| 89 | Horseshoe kidney (HP:0000085) | 1.83634801 |
| 90 | Generalized aminoaciduria (HP:0002909) | 1.83429860 |
| 91 | True hermaphroditism (HP:0010459) | 1.81911796 |
| 92 | Absent thumb (HP:0009777) | 1.81841939 |
| 93 | Aplastic anemia (HP:0001915) | 1.81481124 |
| 94 | Megaloblastic anemia (HP:0001889) | 1.80869507 |
| 95 | Large for gestational age (HP:0001520) | 1.79371945 |
| 96 | Abnormality of methionine metabolism (HP:0010901) | 1.79192661 |
| 97 | Cellular immunodeficiency (HP:0005374) | 1.78251066 |
| 98 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.77059586 |
| 99 | Clubbing of toes (HP:0100760) | 1.76757717 |
| 100 | Opisthotonus (HP:0002179) | 1.73907505 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TSSK6 | 4.53059847 |
| 2 | BMPR1B | 4.40921374 |
| 3 | MST4 | 3.92311649 |
| 4 | ZAK | 3.68691132 |
| 5 | EIF2AK3 | 3.25209258 |
| 6 | EIF2AK1 | 3.22165330 |
| 7 | TXK | 3.13968573 |
| 8 | VRK2 | 3.12545556 |
| 9 | BUB1 | 3.00161889 |
| 10 | VRK1 | 2.58118452 |
| 11 | TLK1 | 2.53097927 |
| 12 | NME1 | 2.42489646 |
| 13 | PBK | 2.34405692 |
| 14 | NUAK1 | 2.34372883 |
| 15 | NEK1 | 2.19032518 |
| 16 | PLK3 | 2.16679773 |
| 17 | SRPK1 | 2.14023392 |
| 18 | TRIM28 | 1.99802262 |
| 19 | TAF1 | 1.94892170 |
| 20 | PASK | 1.68898081 |
| 21 | ADRBK2 | 1.53043576 |
| 22 | MKNK2 | 1.35884912 |
| 23 | TTK | 1.31157895 |
| 24 | TGFBR1 | 1.30655414 |
| 25 | EIF2AK2 | 1.22730758 |
| 26 | ALK | 1.21312614 |
| 27 | CDC7 | 1.19286136 |
| 28 | GRK1 | 1.15720252 |
| 29 | WNK4 | 1.13022335 |
| 30 | TAOK3 | 1.11799861 |
| 31 | TNIK | 1.11607980 |
| 32 | DYRK2 | 1.10899476 |
| 33 | STK39 | 1.03047528 |
| 34 | PLK4 | 1.01617748 |
| 35 | STK16 | 0.97579719 |
| 36 | MKNK1 | 0.95378048 |
| 37 | WNK3 | 0.89987243 |
| 38 | MAP4K2 | 0.88391017 |
| 39 | TEC | 0.85790480 |
| 40 | MAP4K1 | 0.83392656 |
| 41 | WEE1 | 0.81918507 |
| 42 | FRK | 0.80231335 |
| 43 | ATR | 0.79763760 |
| 44 | CDK8 | 0.79009776 |
| 45 | PLK1 | 0.77560453 |
| 46 | DAPK1 | 0.72928181 |
| 47 | BCKDK | 0.70780655 |
| 48 | STK4 | 0.69184430 |
| 49 | TIE1 | 0.64692865 |
| 50 | RPS6KA5 | 0.63696231 |
| 51 | PDK2 | 0.62672343 |
| 52 | AKT3 | 0.62103380 |
| 53 | RPS6KA4 | 0.60852098 |
| 54 | PLK2 | 0.57738466 |
| 55 | SIK3 | 0.57657418 |
| 56 | DYRK3 | 0.53475851 |
| 57 | AURKB | 0.52521692 |
| 58 | MAPKAPK3 | 0.50428292 |
| 59 | OXSR1 | 0.49764981 |
| 60 | FGFR1 | 0.48893642 |
| 61 | IKBKB | 0.48396726 |
| 62 | ITK | 0.48307310 |
| 63 | STK38L | 0.43897782 |
| 64 | ATM | 0.42980821 |
| 65 | CHEK2 | 0.42731088 |
| 66 | IKBKE | 0.41756301 |
| 67 | CDK9 | 0.40009619 |
| 68 | CSNK2A2 | 0.39808340 |
| 69 | CSNK2A1 | 0.39010152 |
| 70 | CCNB1 | 0.38336317 |
| 71 | PHKG1 | 0.36244243 |
| 72 | PHKG2 | 0.36244243 |
| 73 | PAK4 | 0.35415039 |
| 74 | CSNK1A1L | 0.34084904 |
| 75 | BRSK2 | 0.34010882 |
| 76 | NME2 | 0.32289844 |
| 77 | FLT3 | 0.30919899 |
| 78 | NEK9 | 0.30545522 |
| 79 | PNCK | 0.30210828 |
| 80 | CHEK1 | 0.30140502 |
| 81 | LATS1 | 0.29610141 |
| 82 | CSNK1G1 | 0.29398360 |
| 83 | INSRR | 0.29310521 |
| 84 | DAPK3 | 0.28535222 |
| 85 | NLK | 0.28502962 |
| 86 | CSNK1G3 | 0.28404064 |
| 87 | CAMK2D | 0.27727561 |
| 88 | AURKA | 0.27631605 |
| 89 | ERBB4 | 0.27258273 |
| 90 | PRKCE | 0.26520125 |
| 91 | IRAK1 | 0.25459842 |
| 92 | CSNK1A1 | 0.24915031 |
| 93 | PRKCG | 0.24897080 |
| 94 | CSNK1E | 0.24515991 |
| 95 | BCR | 0.24484066 |
| 96 | PRKCQ | 0.24281337 |
| 97 | HIPK2 | 0.24206136 |
| 98 | MAP3K12 | 0.22763456 |
| 99 | STK3 | 0.21553679 |
| 100 | ACVR1B | 0.21547248 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.34783210 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.71506516 |
| 3 | Protein export_Homo sapiens_hsa03060 | 2.99901640 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.64795970 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.51251276 |
| 6 | Ribosome_Homo sapiens_hsa03010 | 2.23470216 |
| 7 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.20508852 |
| 8 | Mismatch repair_Homo sapiens_hsa03430 | 2.18345228 |
| 9 | RNA degradation_Homo sapiens_hsa03018 | 2.12934733 |
| 10 | Parkinsons disease_Homo sapiens_hsa05012 | 2.10614515 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.09475775 |
| 12 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.05751546 |
| 13 | Basal transcription factors_Homo sapiens_hsa03022 | 1.96500253 |
| 14 | RNA transport_Homo sapiens_hsa03013 | 1.94881984 |
| 15 | DNA replication_Homo sapiens_hsa03030 | 1.86922446 |
| 16 | Asthma_Homo sapiens_hsa05310 | 1.86440692 |
| 17 | Allograft rejection_Homo sapiens_hsa05330 | 1.85446677 |
| 18 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.72431110 |
| 19 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.68964588 |
| 20 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.67897597 |
| 21 | Spliceosome_Homo sapiens_hsa03040 | 1.66572779 |
| 22 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.56783978 |
| 23 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.51233249 |
| 24 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.50038002 |
| 25 | Base excision repair_Homo sapiens_hsa03410 | 1.49373464 |
| 26 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.46599069 |
| 27 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.46077825 |
| 28 | Huntingtons disease_Homo sapiens_hsa05016 | 1.45107922 |
| 29 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.43970358 |
| 30 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.42702740 |
| 31 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.42519956 |
| 32 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.39765572 |
| 33 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.28971005 |
| 34 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.26867716 |
| 35 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.22160896 |
| 36 | Purine metabolism_Homo sapiens_hsa00230 | 1.19230415 |
| 37 | Alzheimers disease_Homo sapiens_hsa05010 | 1.19204474 |
| 38 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.09001848 |
| 39 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.04856463 |
| 40 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.02163592 |
| 41 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.00537766 |
| 42 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.00181284 |
| 43 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.98943334 |
| 44 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.98500004 |
| 45 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.97425817 |
| 46 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.96205885 |
| 47 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.94313721 |
| 48 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.92375906 |
| 49 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.89729230 |
| 50 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.89513442 |
| 51 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.89025743 |
| 52 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.88543752 |
| 53 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.83512030 |
| 54 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.83124645 |
| 55 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.80456844 |
| 56 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.78040674 |
| 57 | Peroxisome_Homo sapiens_hsa04146 | 0.76706511 |
| 58 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.75684416 |
| 59 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.75130698 |
| 60 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.75105159 |
| 61 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.74613950 |
| 62 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.73642941 |
| 63 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.69162010 |
| 64 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.68524535 |
| 65 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.68408583 |
| 66 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.66934309 |
| 67 | Metabolic pathways_Homo sapiens_hsa01100 | 0.61107510 |
| 68 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.57521397 |
| 69 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.56836194 |
| 70 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.56243270 |
| 71 | Measles_Homo sapiens_hsa05162 | 0.54543092 |
| 72 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.53652987 |
| 73 | Carbon metabolism_Homo sapiens_hsa01200 | 0.53508310 |
| 74 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.52455096 |
| 75 | Phototransduction_Homo sapiens_hsa04744 | 0.51885603 |
| 76 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.51813716 |
| 77 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.49256455 |
| 78 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.48128035 |
| 79 | Cell cycle_Homo sapiens_hsa04110 | 0.47733094 |
| 80 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.47013433 |
| 81 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.46485148 |
| 82 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.45227259 |
| 83 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.43810632 |
| 84 | Alcoholism_Homo sapiens_hsa05034 | 0.42364426 |
| 85 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.41633907 |
| 86 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.37318629 |
| 87 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.36673821 |
| 88 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.36356795 |
| 89 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.36038011 |
| 90 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.36000257 |
| 91 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.35270699 |
| 92 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.35177968 |
| 93 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.34076134 |
| 94 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.33346978 |
| 95 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.31211615 |
| 96 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.30925390 |
| 97 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.30862106 |
| 98 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.28798271 |
| 99 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.28743158 |
| 100 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.27967115 |

