

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | folic acid-containing compound biosynthetic process (GO:0009396) | 7.07230062 |
| 2 | regulation of isotype switching to IgG isotypes (GO:0048302) | 6.72950967 |
| 3 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 6.31647665 |
| 4 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 6.31647665 |
| 5 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 5.92792768 |
| 6 | positive regulation of interleukin-17 production (GO:0032740) | 5.47533704 |
| 7 | pteridine-containing compound biosynthetic process (GO:0042559) | 5.39702743 |
| 8 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 5.25566519 |
| 9 | mitochondrial RNA metabolic process (GO:0000959) | 4.81668477 |
| 10 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.79214002 |
| 11 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.79214002 |
| 12 | NADH dehydrogenase complex assembly (GO:0010257) | 4.79214002 |
| 13 | homocysteine metabolic process (GO:0050667) | 4.78948572 |
| 14 | regulation of chronic inflammatory response (GO:0002676) | 4.77837352 |
| 15 | positive regulation of DNA recombination (GO:0045911) | 4.69298527 |
| 16 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.65937744 |
| 17 | rRNA modification (GO:0000154) | 4.60934690 |
| 18 | cullin deneddylation (GO:0010388) | 4.58981862 |
| 19 | rRNA methylation (GO:0031167) | 4.56253634 |
| 20 | adenosine metabolic process (GO:0046085) | 4.50221571 |
| 21 | IMP biosynthetic process (GO:0006188) | 4.48692305 |
| 22 | positive regulation of isotype switching (GO:0045830) | 4.38560739 |
| 23 | regulation of immunoglobulin secretion (GO:0051023) | 4.34456026 |
| 24 | protein complex biogenesis (GO:0070271) | 4.30539300 |
| 25 | protein deneddylation (GO:0000338) | 4.23031562 |
| 26 | chaperone-mediated protein transport (GO:0072321) | 4.22628553 |
| 27 | purine nucleotide salvage (GO:0032261) | 4.18771570 |
| 28 | tetrahydrofolate metabolic process (GO:0046653) | 4.17727627 |
| 29 | epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198) | 4.12035681 |
| 30 | regulation of regulatory T cell differentiation (GO:0045589) | 4.04492692 |
| 31 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.00576633 |
| 32 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.98065061 |
| 33 | regulation of plasminogen activation (GO:0010755) | 3.89548618 |
| 34 | transcription from mitochondrial promoter (GO:0006390) | 3.76362710 |
| 35 | protein refolding (GO:0042026) | 3.76077339 |
| 36 | sulfur amino acid catabolic process (GO:0000098) | 3.72164831 |
| 37 | tRNA processing (GO:0008033) | 3.70993604 |
| 38 | tRNA modification (GO:0006400) | 3.68738968 |
| 39 | folic acid-containing compound metabolic process (GO:0006760) | 3.67584880 |
| 40 | ribosome assembly (GO:0042255) | 3.66758284 |
| 41 | IMP metabolic process (GO:0046040) | 3.66736289 |
| 42 | cysteine metabolic process (GO:0006534) | 3.66666883 |
| 43 | ribosome biogenesis (GO:0042254) | 3.65448239 |
| 44 | termination of RNA polymerase I transcription (GO:0006363) | 3.59590571 |
| 45 | pseudouridine synthesis (GO:0001522) | 3.47507264 |
| 46 | positive regulation of immunoglobulin production (GO:0002639) | 3.46722859 |
| 47 | microtubule nucleation (GO:0007020) | 3.46367541 |
| 48 | GTP biosynthetic process (GO:0006183) | 3.44408895 |
| 49 | cytokine production involved in immune response (GO:0002367) | 3.42060279 |
| 50 | negative regulation of acute inflammatory response (GO:0002674) | 3.41917250 |
| 51 | respiratory chain complex IV assembly (GO:0008535) | 3.40604295 |
| 52 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.39957125 |
| 53 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.31757515 |
| 54 | pteridine-containing compound metabolic process (GO:0042558) | 3.30939560 |
| 55 | regulation of vitamin D biosynthetic process (GO:0060556) | 3.27670517 |
| 56 | protein-cofactor linkage (GO:0018065) | 3.26596198 |
| 57 | proteasome assembly (GO:0043248) | 3.26462277 |
| 58 | negative regulation of DNA biosynthetic process (GO:2000279) | 3.18344192 |
| 59 | inner mitochondrial membrane organization (GO:0007007) | 3.12574879 |
| 60 | UTP biosynthetic process (GO:0006228) | 3.09397472 |
| 61 | alternative mRNA splicing, via spliceosome (GO:0000380) | 3.08245720 |
| 62 | positive regulation of B cell mediated immunity (GO:0002714) | 3.07540453 |
| 63 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.07540453 |
| 64 | tRNA metabolic process (GO:0006399) | 3.04685237 |
| 65 | protein targeting to mitochondrion (GO:0006626) | 3.01858323 |
| 66 | regulation of podosome assembly (GO:0071801) | 3.00634231 |
| 67 | signal peptide processing (GO:0006465) | 3.00450294 |
| 68 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.98979463 |
| 69 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 2.98979463 |
| 70 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.92969238 |
| 71 | regulation of isotype switching (GO:0045191) | 2.92785176 |
| 72 | L-serine metabolic process (GO:0006563) | 2.91317568 |
| 73 | protein localization to mitochondrion (GO:0070585) | 2.91222357 |
| 74 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 2.91092255 |
| 75 | T-helper cell differentiation (GO:0042093) | 2.91092255 |
| 76 | intracellular protein transmembrane import (GO:0044743) | 2.90841245 |
| 77 | positive regulation of interleukin-10 production (GO:0032733) | 2.90510879 |
| 78 | DNA deamination (GO:0045006) | 2.88906299 |
| 79 | purine-containing compound salvage (GO:0043101) | 2.87439434 |
| 80 | positive regulation of immune response to tumor cell (GO:0002839) | 2.86813854 |
| 81 | regulation of immune response to tumor cell (GO:0002837) | 2.86813854 |
| 82 | regulation of response to tumor cell (GO:0002834) | 2.86813854 |
| 83 | positive regulation of response to tumor cell (GO:0002836) | 2.86813854 |
| 84 | positive regulation of activated T cell proliferation (GO:0042104) | 2.84253158 |
| 85 | sulfur amino acid biosynthetic process (GO:0000097) | 2.82682781 |
| 86 | platelet dense granule organization (GO:0060155) | 2.81683239 |
| 87 | positive regulation of natural killer cell differentiation (GO:0032825) | 2.81502285 |
| 88 | positive regulation of B cell proliferation (GO:0030890) | 2.81142538 |
| 89 | behavioral response to nicotine (GO:0035095) | 2.80086599 |
| 90 | response to mercury ion (GO:0046689) | 2.79057873 |
| 91 | polyamine metabolic process (GO:0006595) | 2.78890250 |
| 92 | establishment of protein localization to mitochondrion (GO:0072655) | 2.76173427 |
| 93 | UTP metabolic process (GO:0046051) | 2.75558124 |
| 94 | protein-chromophore linkage (GO:0018298) | 2.75462212 |
| 95 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 2.74992019 |
| 96 | protein neddylation (GO:0045116) | 2.74319700 |
| 97 | cellular ketone body metabolic process (GO:0046950) | 2.72951773 |
| 98 | regulation of interleukin-17 production (GO:0032660) | 2.71973709 |
| 99 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.70648013 |
| 100 | alpha-beta T cell activation involved in immune response (GO:0002287) | 2.69188048 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 8.39897602 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.99443250 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.61053944 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.65623566 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.28580872 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.13716098 |
| 7 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 3.04496819 |
| 8 | VDR_22108803_ChIP-Seq_LS180_Human | 2.94337450 |
| 9 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.92780015 |
| 10 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.78094104 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.74815437 |
| 12 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.65403366 |
| 13 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.57820292 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.51034790 |
| 15 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.29624348 |
| 16 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.26778546 |
| 17 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.21299186 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.13227820 |
| 19 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.99200584 |
| 20 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.87380028 |
| 21 | EWS_26573619_Chip-Seq_HEK293_Human | 1.82898893 |
| 22 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.82678073 |
| 23 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.82572953 |
| 24 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.81380350 |
| 25 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.76028377 |
| 26 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.74392280 |
| 27 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.73380345 |
| 28 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.71610291 |
| 29 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.71336977 |
| 30 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.71110198 |
| 31 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.70267444 |
| 32 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.57529546 |
| 33 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.55709350 |
| 34 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.53914433 |
| 35 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.47471246 |
| 36 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.42309772 |
| 37 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.41815360 |
| 38 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.39597117 |
| 39 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.37213686 |
| 40 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.35488356 |
| 41 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.33126470 |
| 42 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.32300637 |
| 43 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.31825550 |
| 44 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.31094828 |
| 45 | FUS_26573619_Chip-Seq_HEK293_Human | 1.30175764 |
| 46 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.29766808 |
| 47 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.29521463 |
| 48 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.26942847 |
| 49 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.25777496 |
| 50 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.23975129 |
| 51 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.23214377 |
| 52 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.21543153 |
| 53 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.20717594 |
| 54 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.19911273 |
| 55 | P300_19829295_ChIP-Seq_ESCs_Human | 1.18366825 |
| 56 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.17778644 |
| 57 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.17189227 |
| 58 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.13768226 |
| 59 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.12352782 |
| 60 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.06880623 |
| 61 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.06575424 |
| 62 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.02707053 |
| 63 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.02346285 |
| 64 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.01016971 |
| 65 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.99826419 |
| 66 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.99826419 |
| 67 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.98477007 |
| 68 | NCOR_22424771_ChIP-Seq_293T_Human | 0.95305444 |
| 69 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.93933346 |
| 70 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.93933346 |
| 71 | GATA3_26560356_Chip-Seq_TH2_Human | 0.93686607 |
| 72 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.93072267 |
| 73 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.91783878 |
| 74 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.91380947 |
| 75 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.91017183 |
| 76 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.89308657 |
| 77 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.89308657 |
| 78 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.89142906 |
| 79 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.89057316 |
| 80 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.88367606 |
| 81 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.86825924 |
| 82 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.86172874 |
| 83 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.85717272 |
| 84 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.85225113 |
| 85 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.85020390 |
| 86 | GATA3_26560356_Chip-Seq_TH1_Human | 0.84932541 |
| 87 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.84794250 |
| 88 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.83878751 |
| 89 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.83478691 |
| 90 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.82154949 |
| 91 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.81885570 |
| 92 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.80672367 |
| 93 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.80000286 |
| 94 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.78729645 |
| 95 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.78051332 |
| 96 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.77274043 |
| 97 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.77081142 |
| 98 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.77072701 |
| 99 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.77009534 |
| 100 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.77005533 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004147_increased_porphyrin_level | 5.63138103 |
| 2 | MP0002138_abnormal_hepatobiliary_system | 4.10731092 |
| 3 | MP0001873_stomach_inflammation | 3.14121073 |
| 4 | MP0008872_abnormal_physiological_respon | 3.09712471 |
| 5 | MP0001348_abnormal_lacrimal_gland | 3.01297447 |
| 6 | MP0008058_abnormal_DNA_repair | 2.83421366 |
| 7 | MP0002736_abnormal_nociception_after | 2.69182480 |
| 8 | MP0005646_abnormal_pituitary_gland | 2.55914253 |
| 9 | MP0005084_abnormal_gallbladder_morpholo | 2.47201200 |
| 10 | MP0001835_abnormal_antigen_presentation | 2.41196274 |
| 11 | MP0008995_early_reproductive_senescence | 2.40144132 |
| 12 | MP0008875_abnormal_xenobiotic_pharmacok | 2.39571671 |
| 13 | MP0005360_urolithiasis | 2.38003426 |
| 14 | MP0003186_abnormal_redox_activity | 2.25176606 |
| 15 | MP0003718_maternal_effect | 2.05177192 |
| 16 | MP0001968_abnormal_touch/_nociception | 2.04521783 |
| 17 | MP0004742_abnormal_vestibular_system | 1.80137544 |
| 18 | MP0004885_abnormal_endolymph | 1.76667648 |
| 19 | MP0003786_premature_aging | 1.71759412 |
| 20 | MP0001853_heart_inflammation | 1.67944839 |
| 21 | MP0000013_abnormal_adipose_tissue | 1.65381169 |
| 22 | MP0003806_abnormal_nucleotide_metabolis | 1.64402545 |
| 23 | MP0000465_gastrointestinal_hemorrhage | 1.57551995 |
| 24 | MP0002938_white_spotting | 1.54353534 |
| 25 | MP0004233_abnormal_muscle_weight | 1.53604866 |
| 26 | MP0005387_immune_system_phenotype | 1.51332594 |
| 27 | MP0001790_abnormal_immune_system | 1.51332594 |
| 28 | MP0009333_abnormal_splenocyte_physiolog | 1.50838284 |
| 29 | MP0005670_abnormal_white_adipose | 1.50813886 |
| 30 | MP0003878_abnormal_ear_physiology | 1.46154695 |
| 31 | MP0005377_hearing/vestibular/ear_phenot | 1.46154695 |
| 32 | MP0009697_abnormal_copulation | 1.41668510 |
| 33 | MP0000685_abnormal_immune_system | 1.36620732 |
| 34 | MP0005551_abnormal_eye_electrophysiolog | 1.34492546 |
| 35 | MP0003646_muscle_fatigue | 1.34271025 |
| 36 | MP0005332_abnormal_amino_acid | 1.32941576 |
| 37 | MP0004142_abnormal_muscle_tone | 1.29347732 |
| 38 | MP0001502_abnormal_circadian_rhythm | 1.23670276 |
| 39 | MP0002837_dystrophic_cardiac_calcinosis | 1.23628953 |
| 40 | MP0005310_abnormal_salivary_gland | 1.22034500 |
| 41 | MP0001661_extended_life_span | 1.20891067 |
| 42 | MP0005636_abnormal_mineral_homeostasis | 1.17595128 |
| 43 | MP0005167_abnormal_blood-brain_barrier | 1.16941481 |
| 44 | MP0002876_abnormal_thyroid_physiology | 1.16758482 |
| 45 | MP0003567_abnormal_fetal_cardiomyocyte | 1.16471401 |
| 46 | MP0005085_abnormal_gallbladder_physiolo | 1.14872608 |
| 47 | MP0003183_abnormal_peptide_metabolism | 1.14148821 |
| 48 | MP0006072_abnormal_retinal_apoptosis | 1.11824416 |
| 49 | MP0001764_abnormal_homeostasis | 1.11469824 |
| 50 | MP0004782_abnormal_surfactant_physiolog | 1.11104613 |
| 51 | MP0002277_abnormal_respiratory_mucosa | 1.09878408 |
| 52 | MP0008877_abnormal_DNA_methylation | 1.09384502 |
| 53 | MP0005253_abnormal_eye_physiology | 1.08456738 |
| 54 | MP0002735_abnormal_chemical_nociception | 1.06139356 |
| 55 | MP0001800_abnormal_humoral_immune | 1.03277923 |
| 56 | MP0002102_abnormal_ear_morphology | 1.02712440 |
| 57 | MP0002148_abnormal_hypersensitivity_rea | 1.02465071 |
| 58 | MP0010094_abnormal_chromosome_stability | 1.01432777 |
| 59 | MP0004043_abnormal_pH_regulation | 0.99646633 |
| 60 | MP0001919_abnormal_reproductive_system | 0.99032633 |
| 61 | MP0009745_abnormal_behavioral_response | 0.97654835 |
| 62 | MP0002163_abnormal_gland_morphology | 0.96902809 |
| 63 | MP0003195_calcinosis | 0.93933209 |
| 64 | MP0004133_heterotaxia | 0.92447351 |
| 65 | MP0004957_abnormal_blastocyst_morpholog | 0.92305209 |
| 66 | MP0005671_abnormal_response_to | 0.85037456 |
| 67 | MP0002095_abnormal_skin_pigmentation | 0.84015689 |
| 68 | MP0002928_abnormal_bile_duct | 0.83132813 |
| 69 | MP0003724_increased_susceptibility_to | 0.82023384 |
| 70 | MP0002693_abnormal_pancreas_physiology | 0.81752543 |
| 71 | MP0000631_abnormal_neuroendocrine_gland | 0.81162166 |
| 72 | MP0001485_abnormal_pinna_reflex | 0.79883130 |
| 73 | MP0000026_abnormal_inner_ear | 0.79786476 |
| 74 | MP0002210_abnormal_sex_determination | 0.79421582 |
| 75 | MP0002254_reproductive_system_inflammat | 0.77555685 |
| 76 | MP0002160_abnormal_reproductive_system | 0.77339629 |
| 77 | MP0002234_abnormal_pharynx_morphology | 0.77182959 |
| 78 | MP0005410_abnormal_fertilization | 0.76851555 |
| 79 | MP0005645_abnormal_hypothalamus_physiol | 0.76317247 |
| 80 | MP0003045_fibrosis | 0.70975689 |
| 81 | MP0001984_abnormal_olfaction | 0.70335535 |
| 82 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.69957526 |
| 83 | MP0002006_tumorigenesis | 0.69816367 |
| 84 | MP0002396_abnormal_hematopoietic_system | 0.69097705 |
| 85 | MP0009764_decreased_sensitivity_to | 0.67250444 |
| 86 | MP0005000_abnormal_immune_tolerance | 0.66747715 |
| 87 | MP0001944_abnormal_pancreas_morphology | 0.66118699 |
| 88 | MP0005389_reproductive_system_phenotype | 0.65799219 |
| 89 | MP0001501_abnormal_sleep_pattern | 0.65246789 |
| 90 | MP0005379_endocrine/exocrine_gland_phen | 0.64899665 |
| 91 | MP0002272_abnormal_nervous_system | 0.64890647 |
| 92 | MP0002405_respiratory_system_inflammati | 0.63093850 |
| 93 | MP0000647_abnormal_sebaceous_gland | 0.62883128 |
| 94 | MP0005395_other_phenotype | 0.62865742 |
| 95 | MP0000653_abnormal_sex_gland | 0.62071125 |
| 96 | MP0003119_abnormal_digestive_system | 0.61143285 |
| 97 | MP0003763_abnormal_thymus_physiology | 0.61018223 |
| 98 | MP0006036_abnormal_mitochondrial_physio | 0.59412872 |
| 99 | MP0001188_hyperpigmentation | 0.58406591 |
| 100 | MP0001486_abnormal_startle_reflex | 0.57975507 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of alanine metabolism (HP:0010916) | 6.41148317 |
| 2 | Hyperalaninemia (HP:0003348) | 6.41148317 |
| 3 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 6.41148317 |
| 4 | Constricted visual fields (HP:0001133) | 4.01256115 |
| 5 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 3.55501255 |
| 6 | Increased hepatocellular lipid droplets (HP:0006565) | 3.48061154 |
| 7 | Congenital sensorineural hearing impairment (HP:0008527) | 3.39297073 |
| 8 | Acute necrotizing encephalopathy (HP:0006965) | 3.34661574 |
| 9 | Type 2 muscle fiber atrophy (HP:0003554) | 3.34524041 |
| 10 | Abnormality of homocysteine metabolism (HP:0010919) | 3.33750464 |
| 11 | Homocystinuria (HP:0002156) | 3.33750464 |
| 12 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.30722957 |
| 13 | Mitochondrial inheritance (HP:0001427) | 3.27648374 |
| 14 | Increased CSF lactate (HP:0002490) | 3.25972206 |
| 15 | Generalized aminoaciduria (HP:0002909) | 3.13319607 |
| 16 | Abnormality of serum amino acid levels (HP:0003112) | 3.09389871 |
| 17 | Lipid accumulation in hepatocytes (HP:0006561) | 3.04957491 |
| 18 | Muscle fiber atrophy (HP:0100295) | 2.99403905 |
| 19 | Increased serum lactate (HP:0002151) | 2.99370925 |
| 20 | Acute encephalopathy (HP:0006846) | 2.97671955 |
| 21 | Pendular nystagmus (HP:0012043) | 2.95398736 |
| 22 | Chorioretinal atrophy (HP:0000533) | 2.93623524 |
| 23 | Methylmalonic acidemia (HP:0002912) | 2.81802990 |
| 24 | Esophageal varix (HP:0002040) | 2.74234065 |
| 25 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.73172385 |
| 26 | Abnormality of the pons (HP:0007361) | 2.67416528 |
| 27 | Progressive macrocephaly (HP:0004481) | 2.63274017 |
| 28 | Fatigue (HP:0012378) | 2.61961342 |
| 29 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.57214678 |
| 30 | Hypoplasia of the pons (HP:0012110) | 2.56207641 |
| 31 | Methylmalonic aciduria (HP:0012120) | 2.55306980 |
| 32 | Renal Fanconi syndrome (HP:0001994) | 2.53657856 |
| 33 | Birth length less than 3rd percentile (HP:0003561) | 2.52505288 |
| 34 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.48273156 |
| 35 | Lactic acidosis (HP:0003128) | 2.46848439 |
| 36 | Abnormality of the renal collecting system (HP:0004742) | 2.44482829 |
| 37 | Anorexia (HP:0002039) | 2.43112770 |
| 38 | Exertional dyspnea (HP:0002875) | 2.42924686 |
| 39 | Hepatocellular necrosis (HP:0001404) | 2.41550935 |
| 40 | Chronic diarrhea (HP:0002028) | 2.38889627 |
| 41 | Poor suck (HP:0002033) | 2.37316733 |
| 42 | Spontaneous hematomas (HP:0007420) | 2.36913658 |
| 43 | Hepatic necrosis (HP:0002605) | 2.36051299 |
| 44 | Increased serum pyruvate (HP:0003542) | 2.34753312 |
| 45 | Abnormality of methionine metabolism (HP:0010901) | 2.34117910 |
| 46 | Duplicated collecting system (HP:0000081) | 2.32452223 |
| 47 | Congenital, generalized hypertrichosis (HP:0004540) | 2.32256234 |
| 48 | Hyperphosphaturia (HP:0003109) | 2.28736501 |
| 49 | Large for gestational age (HP:0001520) | 2.21230364 |
| 50 | Poor speech (HP:0002465) | 2.20764704 |
| 51 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.20742351 |
| 52 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.20742351 |
| 53 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.20651022 |
| 54 | Cerebral hypomyelination (HP:0006808) | 2.16354196 |
| 55 | Short tibia (HP:0005736) | 2.16279012 |
| 56 | Cerebral edema (HP:0002181) | 2.14944095 |
| 57 | Abnormality of the labia minora (HP:0012880) | 2.13939025 |
| 58 | Attenuation of retinal blood vessels (HP:0007843) | 2.13502844 |
| 59 | Pancreatic cysts (HP:0001737) | 2.11351089 |
| 60 | Exercise intolerance (HP:0003546) | 2.10289850 |
| 61 | Megaloblastic anemia (HP:0001889) | 2.10218268 |
| 62 | Abnormality of glycolysis (HP:0004366) | 2.08809547 |
| 63 | 3-Methylglutaconic aciduria (HP:0003535) | 2.05327452 |
| 64 | Hypomagnesemia (HP:0002917) | 2.04697765 |
| 65 | Abnormality of the ileum (HP:0001549) | 2.04012086 |
| 66 | Lethargy (HP:0001254) | 2.02997797 |
| 67 | Patchy hypopigmentation of hair (HP:0011365) | 2.00727631 |
| 68 | Optic disc pallor (HP:0000543) | 1.99668574 |
| 69 | White forelock (HP:0002211) | 1.98737547 |
| 70 | Conjugated hyperbilirubinemia (HP:0002908) | 1.96379141 |
| 71 | Reduced antithrombin III activity (HP:0001976) | 1.96134412 |
| 72 | Meckel diverticulum (HP:0002245) | 1.96085680 |
| 73 | Pigmentary retinal degeneration (HP:0001146) | 1.95372265 |
| 74 | Cavernous hemangioma (HP:0001048) | 1.94365310 |
| 75 | Hyperglycinemia (HP:0002154) | 1.93872459 |
| 76 | Chronic otitis media (HP:0000389) | 1.92165907 |
| 77 | Congenital stationary night blindness (HP:0007642) | 1.91667031 |
| 78 | Paralysis (HP:0003470) | 1.91281310 |
| 79 | Chronic sinusitis (HP:0011109) | 1.89635166 |
| 80 | Progressive cerebellar ataxia (HP:0002073) | 1.88633941 |
| 81 | Abnormality of urine glucose concentration (HP:0011016) | 1.88392059 |
| 82 | Glycosuria (HP:0003076) | 1.88392059 |
| 83 | Type I transferrin isoform profile (HP:0003642) | 1.87930974 |
| 84 | Nausea (HP:0002018) | 1.86996467 |
| 85 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.86819806 |
| 86 | True hermaphroditism (HP:0010459) | 1.86648761 |
| 87 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.85631237 |
| 88 | Pancreatic fibrosis (HP:0100732) | 1.82557343 |
| 89 | Abnormality of glycine metabolism (HP:0010895) | 1.82221869 |
| 90 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.82221869 |
| 91 | Abnormality of midbrain morphology (HP:0002418) | 1.79586719 |
| 92 | Molar tooth sign on MRI (HP:0002419) | 1.79586719 |
| 93 | Increased intramyocellular lipid droplets (HP:0012240) | 1.78562090 |
| 94 | Ileus (HP:0002595) | 1.75628962 |
| 95 | Abolished electroretinogram (ERG) (HP:0000550) | 1.75231916 |
| 96 | Cortical visual impairment (HP:0100704) | 1.74383848 |
| 97 | Chronic hepatic failure (HP:0100626) | 1.73083332 |
| 98 | Bile duct proliferation (HP:0001408) | 1.72729515 |
| 99 | Abnormal biliary tract physiology (HP:0012439) | 1.72729515 |
| 100 | Respiratory difficulties (HP:0002880) | 1.71594494 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TSSK6 | 8.54563221 |
| 2 | EIF2AK1 | 3.68148760 |
| 3 | MST4 | 3.54473439 |
| 4 | PBK | 3.17650851 |
| 5 | EIF2AK3 | 2.86143653 |
| 6 | ACVR1B | 2.78892130 |
| 7 | BUB1 | 2.52934862 |
| 8 | NEK1 | 2.12177546 |
| 9 | VRK2 | 2.11311790 |
| 10 | ADRBK2 | 1.96721470 |
| 11 | NME1 | 1.72680100 |
| 12 | MAP3K3 | 1.60606402 |
| 13 | FRK | 1.52172459 |
| 14 | VRK1 | 1.44246139 |
| 15 | TRIM28 | 1.42114260 |
| 16 | TAF1 | 1.41432598 |
| 17 | TIE1 | 1.35640343 |
| 18 | SRPK1 | 1.35449355 |
| 19 | PLK3 | 1.34890501 |
| 20 | GRK1 | 1.34289274 |
| 21 | TXK | 1.31470796 |
| 22 | PDK2 | 1.30099856 |
| 23 | JAK3 | 1.25056711 |
| 24 | MAPK15 | 1.23813839 |
| 25 | PAK4 | 1.20224882 |
| 26 | TAOK3 | 1.16522543 |
| 27 | SGK2 | 1.11275986 |
| 28 | DYRK2 | 1.10987026 |
| 29 | RPS6KB2 | 1.10847035 |
| 30 | WNK4 | 1.10779103 |
| 31 | MKNK2 | 1.10514774 |
| 32 | FGR | 1.03239972 |
| 33 | NUAK1 | 1.00652575 |
| 34 | ZAK | 0.99736335 |
| 35 | SGK494 | 0.94367131 |
| 36 | SGK223 | 0.94367131 |
| 37 | MAP4K2 | 0.88732336 |
| 38 | BCKDK | 0.88649433 |
| 39 | MAP2K3 | 0.87590126 |
| 40 | WNK3 | 0.87276804 |
| 41 | MKNK1 | 0.86612929 |
| 42 | DAPK2 | 0.83747247 |
| 43 | NTRK2 | 0.83738957 |
| 44 | IKBKB | 0.78867308 |
| 45 | TEC | 0.78672760 |
| 46 | PAK6 | 0.76474240 |
| 47 | CDK9 | 0.76336965 |
| 48 | SIK3 | 0.75843009 |
| 49 | ADRBK1 | 0.74427389 |
| 50 | TLK1 | 0.73452943 |
| 51 | STK38L | 0.70553820 |
| 52 | PHKG2 | 0.69981036 |
| 53 | PHKG1 | 0.69981036 |
| 54 | EIF2AK2 | 0.69639997 |
| 55 | PAK3 | 0.69511254 |
| 56 | BMPR1B | 0.68681656 |
| 57 | INSRR | 0.67960110 |
| 58 | PLK4 | 0.66576749 |
| 59 | BCR | 0.66511484 |
| 60 | CCNB1 | 0.65722509 |
| 61 | PRKCE | 0.63667246 |
| 62 | ALK | 0.60615319 |
| 63 | CDK8 | 0.60411873 |
| 64 | ITK | 0.59552369 |
| 65 | IRAK1 | 0.59420848 |
| 66 | PLK1 | 0.58924121 |
| 67 | STK39 | 0.57503359 |
| 68 | OXSR1 | 0.57056396 |
| 69 | BRD4 | 0.49627441 |
| 70 | CSNK1A1 | 0.49318787 |
| 71 | MAPK13 | 0.47325401 |
| 72 | PASK | 0.46782639 |
| 73 | PRKD3 | 0.45136044 |
| 74 | PIK3CG | 0.44297129 |
| 75 | PLK2 | 0.42489149 |
| 76 | ATR | 0.42458646 |
| 77 | SGK3 | 0.41820850 |
| 78 | AKT3 | 0.41617413 |
| 79 | CSNK2A2 | 0.41087456 |
| 80 | CAMK2A | 0.40135839 |
| 81 | IKBKE | 0.37569851 |
| 82 | SGK1 | 0.37379758 |
| 83 | CSNK2A1 | 0.35870582 |
| 84 | STK16 | 0.35677452 |
| 85 | MAP2K6 | 0.34392480 |
| 86 | TGFBR1 | 0.33795704 |
| 87 | STK3 | 0.32749538 |
| 88 | STK4 | 0.32049243 |
| 89 | NLK | 0.31547739 |
| 90 | CAMKK2 | 0.31509756 |
| 91 | MAPKAPK3 | 0.30165273 |
| 92 | CAMK2D | 0.29803668 |
| 93 | NEK9 | 0.29778804 |
| 94 | MAPKAPK5 | 0.29419797 |
| 95 | IRAK4 | 0.29113032 |
| 96 | RPS6KA5 | 0.28680948 |
| 97 | FGFR1 | 0.28016514 |
| 98 | DAPK1 | 0.27713824 |
| 99 | PRKCG | 0.27682377 |
| 100 | RPS6KA1 | 0.26692511 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.04696039 |
| 2 | One carbon pool by folate_Homo sapiens_hsa00670 | 3.92906764 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.56315713 |
| 4 | Protein export_Homo sapiens_hsa03060 | 3.14740442 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.62436406 |
| 6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.33836343 |
| 7 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.29880834 |
| 8 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.25953590 |
| 9 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.04398027 |
| 10 | Basal transcription factors_Homo sapiens_hsa03022 | 1.91079338 |
| 11 | Parkinsons disease_Homo sapiens_hsa05012 | 1.85680926 |
| 12 | Asthma_Homo sapiens_hsa05310 | 1.85538056 |
| 13 | Spliceosome_Homo sapiens_hsa03040 | 1.80874217 |
| 14 | RNA degradation_Homo sapiens_hsa03018 | 1.75311427 |
| 15 | Allograft rejection_Homo sapiens_hsa05330 | 1.72157716 |
| 16 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.67711372 |
| 17 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.66884983 |
| 18 | RNA transport_Homo sapiens_hsa03013 | 1.62990271 |
| 19 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.60044444 |
| 20 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.59734972 |
| 21 | Sulfur relay system_Homo sapiens_hsa04122 | 1.59094806 |
| 22 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.58019420 |
| 23 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.52281187 |
| 24 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.50866606 |
| 25 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.42470040 |
| 26 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.41374731 |
| 27 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.35055724 |
| 28 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.32399773 |
| 29 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.31399426 |
| 30 | Homologous recombination_Homo sapiens_hsa03440 | 1.31370521 |
| 31 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.28517059 |
| 32 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.23357679 |
| 33 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.18358884 |
| 34 | Huntingtons disease_Homo sapiens_hsa05016 | 1.17859696 |
| 35 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.17810507 |
| 36 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.15773194 |
| 37 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.13244868 |
| 38 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.11488284 |
| 39 | Ribosome_Homo sapiens_hsa03010 | 1.10228347 |
| 40 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.07490348 |
| 41 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.06793246 |
| 42 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.05892802 |
| 43 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.04422334 |
| 44 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.04380745 |
| 45 | Mismatch repair_Homo sapiens_hsa03430 | 1.01190285 |
| 46 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.00806154 |
| 47 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.98696169 |
| 48 | Purine metabolism_Homo sapiens_hsa00230 | 0.97652825 |
| 49 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.93647723 |
| 50 | Peroxisome_Homo sapiens_hsa04146 | 0.93077919 |
| 51 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.90132878 |
| 52 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.90070039 |
| 53 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.89561075 |
| 54 | Alzheimers disease_Homo sapiens_hsa05010 | 0.88428311 |
| 55 | Phototransduction_Homo sapiens_hsa04744 | 0.86131848 |
| 56 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.84282390 |
| 57 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.83197400 |
| 58 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.81630828 |
| 59 | Retinol metabolism_Homo sapiens_hsa00830 | 0.80445225 |
| 60 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.78855844 |
| 61 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.78195291 |
| 62 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.74761246 |
| 63 | Olfactory transduction_Homo sapiens_hsa04740 | 0.73740009 |
| 64 | Legionellosis_Homo sapiens_hsa05134 | 0.73673148 |
| 65 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.73400585 |
| 66 | Mineral absorption_Homo sapiens_hsa04978 | 0.68608768 |
| 67 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.66942308 |
| 68 | Metabolic pathways_Homo sapiens_hsa01100 | 0.66745957 |
| 69 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.66644110 |
| 70 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.64744023 |
| 71 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.63725008 |
| 72 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.63167636 |
| 73 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.62587585 |
| 74 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.59722420 |
| 75 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.58862540 |
| 76 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.58549778 |
| 77 | Measles_Homo sapiens_hsa05162 | 0.57416861 |
| 78 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.56505949 |
| 79 | GABAergic synapse_Homo sapiens_hsa04727 | 0.56400813 |
| 80 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.56198639 |
| 81 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.55580428 |
| 82 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.55291422 |
| 83 | Morphine addiction_Homo sapiens_hsa05032 | 0.55080135 |
| 84 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.55018949 |
| 85 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.54177311 |
| 86 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.53923576 |
| 87 | Nicotine addiction_Homo sapiens_hsa05033 | 0.53435424 |
| 88 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.52417802 |
| 89 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.47218021 |
| 90 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.45946508 |
| 91 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.44245517 |
| 92 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.43078204 |
| 93 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.42700434 |
| 94 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.42408580 |
| 95 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.41229947 |
| 96 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.41047067 |
| 97 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.40352754 |
| 98 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.39590791 |
| 99 | Base excision repair_Homo sapiens_hsa03410 | 0.39457123 |
| 100 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.39245980 |

