HSPD1P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)7.07230062
2regulation of isotype switching to IgG isotypes (GO:0048302)6.72950967
3RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.31647665
4tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.31647665
5positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.92792768
6positive regulation of interleukin-17 production (GO:0032740)5.47533704
7pteridine-containing compound biosynthetic process (GO:0042559)5.39702743
8regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.25566519
9mitochondrial RNA metabolic process (GO:0000959)4.81668477
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.79214002
11mitochondrial respiratory chain complex I assembly (GO:0032981)4.79214002
12NADH dehydrogenase complex assembly (GO:0010257)4.79214002
13homocysteine metabolic process (GO:0050667)4.78948572
14regulation of chronic inflammatory response (GO:0002676)4.77837352
15positive regulation of DNA recombination (GO:0045911)4.69298527
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.65937744
17rRNA modification (GO:0000154)4.60934690
18cullin deneddylation (GO:0010388)4.58981862
19rRNA methylation (GO:0031167)4.56253634
20adenosine metabolic process (GO:0046085)4.50221571
21IMP biosynthetic process (GO:0006188)4.48692305
22positive regulation of isotype switching (GO:0045830)4.38560739
23regulation of immunoglobulin secretion (GO:0051023)4.34456026
24protein complex biogenesis (GO:0070271)4.30539300
25protein deneddylation (GO:0000338)4.23031562
26chaperone-mediated protein transport (GO:0072321)4.22628553
27purine nucleotide salvage (GO:0032261)4.18771570
28tetrahydrofolate metabolic process (GO:0046653)4.17727627
29epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.12035681
30regulation of regulatory T cell differentiation (GO:0045589)4.04492692
31water-soluble vitamin biosynthetic process (GO:0042364)4.00576633
32mitochondrial respiratory chain complex assembly (GO:0033108)3.98065061
33regulation of plasminogen activation (GO:0010755)3.89548618
34transcription from mitochondrial promoter (GO:0006390)3.76362710
35protein refolding (GO:0042026)3.76077339
36sulfur amino acid catabolic process (GO:0000098)3.72164831
37tRNA processing (GO:0008033)3.70993604
38tRNA modification (GO:0006400)3.68738968
39folic acid-containing compound metabolic process (GO:0006760)3.67584880
40ribosome assembly (GO:0042255)3.66758284
41IMP metabolic process (GO:0046040)3.66736289
42cysteine metabolic process (GO:0006534)3.66666883
43ribosome biogenesis (GO:0042254)3.65448239
44termination of RNA polymerase I transcription (GO:0006363)3.59590571
45pseudouridine synthesis (GO:0001522)3.47507264
46positive regulation of immunoglobulin production (GO:0002639)3.46722859
47microtubule nucleation (GO:0007020)3.46367541
48GTP biosynthetic process (GO:0006183)3.44408895
49cytokine production involved in immune response (GO:0002367)3.42060279
50negative regulation of acute inflammatory response (GO:0002674)3.41917250
51respiratory chain complex IV assembly (GO:0008535)3.40604295
52CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.39957125
53transcription elongation from RNA polymerase I promoter (GO:0006362)3.31757515
54pteridine-containing compound metabolic process (GO:0042558)3.30939560
55regulation of vitamin D biosynthetic process (GO:0060556)3.27670517
56protein-cofactor linkage (GO:0018065)3.26596198
57proteasome assembly (GO:0043248)3.26462277
58negative regulation of DNA biosynthetic process (GO:2000279)3.18344192
59inner mitochondrial membrane organization (GO:0007007)3.12574879
60UTP biosynthetic process (GO:0006228)3.09397472
61alternative mRNA splicing, via spliceosome (GO:0000380)3.08245720
62positive regulation of B cell mediated immunity (GO:0002714)3.07540453
63positive regulation of immunoglobulin mediated immune response (GO:0002891)3.07540453
64tRNA metabolic process (GO:0006399)3.04685237
65protein targeting to mitochondrion (GO:0006626)3.01858323
66regulation of podosome assembly (GO:0071801)3.00634231
67signal peptide processing (GO:0006465)3.00450294
68negative regulation of T-helper cell differentiation (GO:0045623)2.98979463
69negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.98979463
70guanosine-containing compound biosynthetic process (GO:1901070)2.92969238
71regulation of isotype switching (GO:0045191)2.92785176
72L-serine metabolic process (GO:0006563)2.91317568
73protein localization to mitochondrion (GO:0070585)2.91222357
74CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.91092255
75T-helper cell differentiation (GO:0042093)2.91092255
76intracellular protein transmembrane import (GO:0044743)2.90841245
77positive regulation of interleukin-10 production (GO:0032733)2.90510879
78DNA deamination (GO:0045006)2.88906299
79purine-containing compound salvage (GO:0043101)2.87439434
80positive regulation of immune response to tumor cell (GO:0002839)2.86813854
81regulation of immune response to tumor cell (GO:0002837)2.86813854
82regulation of response to tumor cell (GO:0002834)2.86813854
83positive regulation of response to tumor cell (GO:0002836)2.86813854
84positive regulation of activated T cell proliferation (GO:0042104)2.84253158
85sulfur amino acid biosynthetic process (GO:0000097)2.82682781
86platelet dense granule organization (GO:0060155)2.81683239
87positive regulation of natural killer cell differentiation (GO:0032825)2.81502285
88positive regulation of B cell proliferation (GO:0030890)2.81142538
89behavioral response to nicotine (GO:0035095)2.80086599
90response to mercury ion (GO:0046689)2.79057873
91polyamine metabolic process (GO:0006595)2.78890250
92establishment of protein localization to mitochondrion (GO:0072655)2.76173427
93UTP metabolic process (GO:0046051)2.75558124
94protein-chromophore linkage (GO:0018298)2.75462212
95transcription initiation from RNA polymerase I promoter (GO:0006361)2.74992019
96protein neddylation (GO:0045116)2.74319700
97cellular ketone body metabolic process (GO:0046950)2.72951773
98regulation of interleukin-17 production (GO:0032660)2.71973709
99regulation of cellular amino acid metabolic process (GO:0006521)2.70648013
100alpha-beta T cell activation involved in immune response (GO:0002287)2.69188048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse8.39897602
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.99443250
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.61053944
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.65623566
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.28580872
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.13716098
7NOTCH1_21737748_ChIP-Seq_TLL_Human3.04496819
8VDR_22108803_ChIP-Seq_LS180_Human2.94337450
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92780015
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.78094104
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.74815437
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65403366
13VDR_23849224_ChIP-Seq_CD4+_Human2.57820292
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51034790
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.29624348
16ELK1_19687146_ChIP-ChIP_HELA_Human2.26778546
17FOXP3_21729870_ChIP-Seq_TREG_Human2.21299186
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13227820
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.99200584
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.87380028
21EWS_26573619_Chip-Seq_HEK293_Human1.82898893
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82678073
23TAF15_26573619_Chip-Seq_HEK293_Human1.82572953
24ZNF274_21170338_ChIP-Seq_K562_Hela1.81380350
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76028377
26GABP_19822575_ChIP-Seq_HepG2_Human1.74392280
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73380345
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71610291
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71336977
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71110198
31TP53_22573176_ChIP-Seq_HFKS_Human1.70267444
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57529546
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55709350
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.53914433
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.47471246
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42309772
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41815360
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39597117
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37213686
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35488356
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33126470
42TTF2_22483619_ChIP-Seq_HELA_Human1.32300637
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31825550
44XRN2_22483619_ChIP-Seq_HELA_Human1.31094828
45FUS_26573619_Chip-Seq_HEK293_Human1.30175764
46MYC_18940864_ChIP-ChIP_HL60_Human1.29766808
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.29521463
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26942847
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25777496
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23975129
51DCP1A_22483619_ChIP-Seq_HELA_Human1.23214377
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21543153
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20717594
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19911273
55P300_19829295_ChIP-Seq_ESCs_Human1.18366825
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.17778644
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17189227
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13768226
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12352782
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06880623
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06575424
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.02707053
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02346285
64LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01016971
65FOXA1_25329375_ChIP-Seq_VCAP_Human0.99826419
66FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99826419
67CDX2_22108803_ChIP-Seq_LS180_Human0.98477007
68NCOR_22424771_ChIP-Seq_293T_Human0.95305444
69SOX2_19829295_ChIP-Seq_ESCs_Human0.93933346
70NANOG_19829295_ChIP-Seq_ESCs_Human0.93933346
71GATA3_26560356_Chip-Seq_TH2_Human0.93686607
72E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93072267
73HOXB7_26014856_ChIP-Seq_BT474_Human0.91783878
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91380947
75CRX_20693478_ChIP-Seq_RETINA_Mouse0.91017183
76CBP_20019798_ChIP-Seq_JUKART_Human0.89308657
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89308657
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89142906
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89057316
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88367606
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86825924
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86172874
83MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85717272
84PHF8_20622853_ChIP-Seq_HELA_Human0.85225113
85FOXH1_21741376_ChIP-Seq_EPCs_Human0.85020390
86GATA3_26560356_Chip-Seq_TH1_Human0.84932541
87FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84794250
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83878751
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83478691
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82154949
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81885570
92FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.80672367
93POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80000286
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.78729645
95KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.78051332
96NELFA_20434984_ChIP-Seq_ESCs_Mouse0.77274043
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.77081142
98TCF4_22108803_ChIP-Seq_LS180_Human0.77072701
99POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77009534
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.77005533

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.63138103
2MP0002138_abnormal_hepatobiliary_system4.10731092
3MP0001873_stomach_inflammation3.14121073
4MP0008872_abnormal_physiological_respon3.09712471
5MP0001348_abnormal_lacrimal_gland3.01297447
6MP0008058_abnormal_DNA_repair2.83421366
7MP0002736_abnormal_nociception_after2.69182480
8MP0005646_abnormal_pituitary_gland2.55914253
9MP0005084_abnormal_gallbladder_morpholo2.47201200
10MP0001835_abnormal_antigen_presentation2.41196274
11MP0008995_early_reproductive_senescence2.40144132
12MP0008875_abnormal_xenobiotic_pharmacok2.39571671
13MP0005360_urolithiasis2.38003426
14MP0003186_abnormal_redox_activity2.25176606
15MP0003718_maternal_effect2.05177192
16MP0001968_abnormal_touch/_nociception2.04521783
17MP0004742_abnormal_vestibular_system1.80137544
18MP0004885_abnormal_endolymph1.76667648
19MP0003786_premature_aging1.71759412
20MP0001853_heart_inflammation1.67944839
21MP0000013_abnormal_adipose_tissue1.65381169
22MP0003806_abnormal_nucleotide_metabolis1.64402545
23MP0000465_gastrointestinal_hemorrhage1.57551995
24MP0002938_white_spotting1.54353534
25MP0004233_abnormal_muscle_weight1.53604866
26MP0005387_immune_system_phenotype1.51332594
27MP0001790_abnormal_immune_system1.51332594
28MP0009333_abnormal_splenocyte_physiolog1.50838284
29MP0005670_abnormal_white_adipose1.50813886
30MP0003878_abnormal_ear_physiology1.46154695
31MP0005377_hearing/vestibular/ear_phenot1.46154695
32MP0009697_abnormal_copulation1.41668510
33MP0000685_abnormal_immune_system1.36620732
34MP0005551_abnormal_eye_electrophysiolog1.34492546
35MP0003646_muscle_fatigue1.34271025
36MP0005332_abnormal_amino_acid1.32941576
37MP0004142_abnormal_muscle_tone1.29347732
38MP0001502_abnormal_circadian_rhythm1.23670276
39MP0002837_dystrophic_cardiac_calcinosis1.23628953
40MP0005310_abnormal_salivary_gland1.22034500
41MP0001661_extended_life_span1.20891067
42MP0005636_abnormal_mineral_homeostasis1.17595128
43MP0005167_abnormal_blood-brain_barrier1.16941481
44MP0002876_abnormal_thyroid_physiology1.16758482
45MP0003567_abnormal_fetal_cardiomyocyte1.16471401
46MP0005085_abnormal_gallbladder_physiolo1.14872608
47MP0003183_abnormal_peptide_metabolism1.14148821
48MP0006072_abnormal_retinal_apoptosis1.11824416
49MP0001764_abnormal_homeostasis1.11469824
50MP0004782_abnormal_surfactant_physiolog1.11104613
51MP0002277_abnormal_respiratory_mucosa1.09878408
52MP0008877_abnormal_DNA_methylation1.09384502
53MP0005253_abnormal_eye_physiology1.08456738
54MP0002735_abnormal_chemical_nociception1.06139356
55MP0001800_abnormal_humoral_immune1.03277923
56MP0002102_abnormal_ear_morphology1.02712440
57MP0002148_abnormal_hypersensitivity_rea1.02465071
58MP0010094_abnormal_chromosome_stability1.01432777
59MP0004043_abnormal_pH_regulation0.99646633
60MP0001919_abnormal_reproductive_system0.99032633
61MP0009745_abnormal_behavioral_response0.97654835
62MP0002163_abnormal_gland_morphology0.96902809
63MP0003195_calcinosis0.93933209
64MP0004133_heterotaxia0.92447351
65MP0004957_abnormal_blastocyst_morpholog0.92305209
66MP0005671_abnormal_response_to0.85037456
67MP0002095_abnormal_skin_pigmentation0.84015689
68MP0002928_abnormal_bile_duct0.83132813
69MP0003724_increased_susceptibility_to0.82023384
70MP0002693_abnormal_pancreas_physiology0.81752543
71MP0000631_abnormal_neuroendocrine_gland0.81162166
72MP0001485_abnormal_pinna_reflex0.79883130
73MP0000026_abnormal_inner_ear0.79786476
74MP0002210_abnormal_sex_determination0.79421582
75MP0002254_reproductive_system_inflammat0.77555685
76MP0002160_abnormal_reproductive_system0.77339629
77MP0002234_abnormal_pharynx_morphology0.77182959
78MP0005410_abnormal_fertilization0.76851555
79MP0005645_abnormal_hypothalamus_physiol0.76317247
80MP0003045_fibrosis0.70975689
81MP0001984_abnormal_olfaction0.70335535
82MP0005584_abnormal_enzyme/coenzyme_acti0.69957526
83MP0002006_tumorigenesis0.69816367
84MP0002396_abnormal_hematopoietic_system0.69097705
85MP0009764_decreased_sensitivity_to0.67250444
86MP0005000_abnormal_immune_tolerance0.66747715
87MP0001944_abnormal_pancreas_morphology0.66118699
88MP0005389_reproductive_system_phenotype0.65799219
89MP0001501_abnormal_sleep_pattern0.65246789
90MP0005379_endocrine/exocrine_gland_phen0.64899665
91MP0002272_abnormal_nervous_system0.64890647
92MP0002405_respiratory_system_inflammati0.63093850
93MP0000647_abnormal_sebaceous_gland0.62883128
94MP0005395_other_phenotype0.62865742
95MP0000653_abnormal_sex_gland0.62071125
96MP0003119_abnormal_digestive_system0.61143285
97MP0003763_abnormal_thymus_physiology0.61018223
98MP0006036_abnormal_mitochondrial_physio0.59412872
99MP0001188_hyperpigmentation0.58406591
100MP0001486_abnormal_startle_reflex0.57975507

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)6.41148317
2Hyperalaninemia (HP:0003348)6.41148317
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.41148317
4Constricted visual fields (HP:0001133)4.01256115
5Decreased electroretinogram (ERG) amplitude (HP:0000654)3.55501255
6Increased hepatocellular lipid droplets (HP:0006565)3.48061154
7Congenital sensorineural hearing impairment (HP:0008527)3.39297073
8Acute necrotizing encephalopathy (HP:0006965)3.34661574
9Type 2 muscle fiber atrophy (HP:0003554)3.34524041
10Abnormality of homocysteine metabolism (HP:0010919)3.33750464
11Homocystinuria (HP:0002156)3.33750464
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.30722957
13Mitochondrial inheritance (HP:0001427)3.27648374
14Increased CSF lactate (HP:0002490)3.25972206
15Generalized aminoaciduria (HP:0002909)3.13319607
16Abnormality of serum amino acid levels (HP:0003112)3.09389871
17Lipid accumulation in hepatocytes (HP:0006561)3.04957491
18Muscle fiber atrophy (HP:0100295)2.99403905
19Increased serum lactate (HP:0002151)2.99370925
20Acute encephalopathy (HP:0006846)2.97671955
21Pendular nystagmus (HP:0012043)2.95398736
22Chorioretinal atrophy (HP:0000533)2.93623524
23Methylmalonic acidemia (HP:0002912)2.81802990
24Esophageal varix (HP:0002040)2.74234065
25Abnormal mitochondria in muscle tissue (HP:0008316)2.73172385
26Abnormality of the pons (HP:0007361)2.67416528
27Progressive macrocephaly (HP:0004481)2.63274017
28Fatigue (HP:0012378)2.61961342
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.57214678
30Hypoplasia of the pons (HP:0012110)2.56207641
31Methylmalonic aciduria (HP:0012120)2.55306980
32Renal Fanconi syndrome (HP:0001994)2.53657856
33Birth length less than 3rd percentile (HP:0003561)2.52505288
34Abnormality of sulfur amino acid metabolism (HP:0004339)2.48273156
35Lactic acidosis (HP:0003128)2.46848439
36Abnormality of the renal collecting system (HP:0004742)2.44482829
37Anorexia (HP:0002039)2.43112770
38Exertional dyspnea (HP:0002875)2.42924686
39Hepatocellular necrosis (HP:0001404)2.41550935
40Chronic diarrhea (HP:0002028)2.38889627
41Poor suck (HP:0002033)2.37316733
42Spontaneous hematomas (HP:0007420)2.36913658
43Hepatic necrosis (HP:0002605)2.36051299
44Increased serum pyruvate (HP:0003542)2.34753312
45Abnormality of methionine metabolism (HP:0010901)2.34117910
46Duplicated collecting system (HP:0000081)2.32452223
47Congenital, generalized hypertrichosis (HP:0004540)2.32256234
48Hyperphosphaturia (HP:0003109)2.28736501
49Large for gestational age (HP:0001520)2.21230364
50Poor speech (HP:0002465)2.20764704
51Abnormal respiratory motile cilium morphology (HP:0005938)2.20742351
52Abnormal respiratory epithelium morphology (HP:0012253)2.20742351
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.20651022
54Cerebral hypomyelination (HP:0006808)2.16354196
55Short tibia (HP:0005736)2.16279012
56Cerebral edema (HP:0002181)2.14944095
57Abnormality of the labia minora (HP:0012880)2.13939025
58Attenuation of retinal blood vessels (HP:0007843)2.13502844
59Pancreatic cysts (HP:0001737)2.11351089
60Exercise intolerance (HP:0003546)2.10289850
61Megaloblastic anemia (HP:0001889)2.10218268
62Abnormality of glycolysis (HP:0004366)2.08809547
633-Methylglutaconic aciduria (HP:0003535)2.05327452
64Hypomagnesemia (HP:0002917)2.04697765
65Abnormality of the ileum (HP:0001549)2.04012086
66Lethargy (HP:0001254)2.02997797
67Patchy hypopigmentation of hair (HP:0011365)2.00727631
68Optic disc pallor (HP:0000543)1.99668574
69White forelock (HP:0002211)1.98737547
70Conjugated hyperbilirubinemia (HP:0002908)1.96379141
71Reduced antithrombin III activity (HP:0001976)1.96134412
72Meckel diverticulum (HP:0002245)1.96085680
73Pigmentary retinal degeneration (HP:0001146)1.95372265
74Cavernous hemangioma (HP:0001048)1.94365310
75Hyperglycinemia (HP:0002154)1.93872459
76Chronic otitis media (HP:0000389)1.92165907
77Congenital stationary night blindness (HP:0007642)1.91667031
78Paralysis (HP:0003470)1.91281310
79Chronic sinusitis (HP:0011109)1.89635166
80Progressive cerebellar ataxia (HP:0002073)1.88633941
81Abnormality of urine glucose concentration (HP:0011016)1.88392059
82Glycosuria (HP:0003076)1.88392059
83Type I transferrin isoform profile (HP:0003642)1.87930974
84Nausea (HP:0002018)1.86996467
85Aplasia/hypoplasia of the uterus (HP:0008684)1.86819806
86True hermaphroditism (HP:0010459)1.86648761
87Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85631237
88Pancreatic fibrosis (HP:0100732)1.82557343
89Abnormality of glycine metabolism (HP:0010895)1.82221869
90Abnormality of serine family amino acid metabolism (HP:0010894)1.82221869
91Abnormality of midbrain morphology (HP:0002418)1.79586719
92Molar tooth sign on MRI (HP:0002419)1.79586719
93Increased intramyocellular lipid droplets (HP:0012240)1.78562090
94Ileus (HP:0002595)1.75628962
95Abolished electroretinogram (ERG) (HP:0000550)1.75231916
96Cortical visual impairment (HP:0100704)1.74383848
97Chronic hepatic failure (HP:0100626)1.73083332
98Bile duct proliferation (HP:0001408)1.72729515
99Abnormal biliary tract physiology (HP:0012439)1.72729515
100Respiratory difficulties (HP:0002880)1.71594494

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK68.54563221
2EIF2AK13.68148760
3MST43.54473439
4PBK3.17650851
5EIF2AK32.86143653
6ACVR1B2.78892130
7BUB12.52934862
8NEK12.12177546
9VRK22.11311790
10ADRBK21.96721470
11NME11.72680100
12MAP3K31.60606402
13FRK1.52172459
14VRK11.44246139
15TRIM281.42114260
16TAF11.41432598
17TIE11.35640343
18SRPK11.35449355
19PLK31.34890501
20GRK11.34289274
21TXK1.31470796
22PDK21.30099856
23JAK31.25056711
24MAPK151.23813839
25PAK41.20224882
26TAOK31.16522543
27SGK21.11275986
28DYRK21.10987026
29RPS6KB21.10847035
30WNK41.10779103
31MKNK21.10514774
32FGR1.03239972
33NUAK11.00652575
34ZAK0.99736335
35SGK4940.94367131
36SGK2230.94367131
37MAP4K20.88732336
38BCKDK0.88649433
39MAP2K30.87590126
40WNK30.87276804
41MKNK10.86612929
42DAPK20.83747247
43NTRK20.83738957
44IKBKB0.78867308
45TEC0.78672760
46PAK60.76474240
47CDK90.76336965
48SIK30.75843009
49ADRBK10.74427389
50TLK10.73452943
51STK38L0.70553820
52PHKG20.69981036
53PHKG10.69981036
54EIF2AK20.69639997
55PAK30.69511254
56BMPR1B0.68681656
57INSRR0.67960110
58PLK40.66576749
59BCR0.66511484
60CCNB10.65722509
61PRKCE0.63667246
62ALK0.60615319
63CDK80.60411873
64ITK0.59552369
65IRAK10.59420848
66PLK10.58924121
67STK390.57503359
68OXSR10.57056396
69BRD40.49627441
70CSNK1A10.49318787
71MAPK130.47325401
72PASK0.46782639
73PRKD30.45136044
74PIK3CG0.44297129
75PLK20.42489149
76ATR0.42458646
77SGK30.41820850
78AKT30.41617413
79CSNK2A20.41087456
80CAMK2A0.40135839
81IKBKE0.37569851
82SGK10.37379758
83CSNK2A10.35870582
84STK160.35677452
85MAP2K60.34392480
86TGFBR10.33795704
87STK30.32749538
88STK40.32049243
89NLK0.31547739
90CAMKK20.31509756
91MAPKAPK30.30165273
92CAMK2D0.29803668
93NEK90.29778804
94MAPKAPK50.29419797
95IRAK40.29113032
96RPS6KA50.28680948
97FGFR10.28016514
98DAPK10.27713824
99PRKCG0.27682377
100RPS6KA10.26692511

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.04696039
2One carbon pool by folate_Homo sapiens_hsa006703.92906764
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.56315713
4Protein export_Homo sapiens_hsa030603.14740442
5RNA polymerase_Homo sapiens_hsa030202.62436406
6Oxidative phosphorylation_Homo sapiens_hsa001902.33836343
7Sulfur metabolism_Homo sapiens_hsa009202.29880834
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25953590
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04398027
10Basal transcription factors_Homo sapiens_hsa030221.91079338
11Parkinsons disease_Homo sapiens_hsa050121.85680926
12Asthma_Homo sapiens_hsa053101.85538056
13Spliceosome_Homo sapiens_hsa030401.80874217
14RNA degradation_Homo sapiens_hsa030181.75311427
15Allograft rejection_Homo sapiens_hsa053301.72157716
16Autoimmune thyroid disease_Homo sapiens_hsa053201.67711372
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.66884983
18RNA transport_Homo sapiens_hsa030131.62990271
19Selenocompound metabolism_Homo sapiens_hsa004501.60044444
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59734972
21Sulfur relay system_Homo sapiens_hsa041221.59094806
22Arginine biosynthesis_Homo sapiens_hsa002201.58019420
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.52281187
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50866606
25Caffeine metabolism_Homo sapiens_hsa002321.42470040
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41374731
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.35055724
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32399773
29Collecting duct acid secretion_Homo sapiens_hsa049661.31399426
30Homologous recombination_Homo sapiens_hsa034401.31370521
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28517059
32Nitrogen metabolism_Homo sapiens_hsa009101.23357679
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18358884
34Huntingtons disease_Homo sapiens_hsa050161.17859696
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17810507
36Type I diabetes mellitus_Homo sapiens_hsa049401.15773194
37Propanoate metabolism_Homo sapiens_hsa006401.13244868
38Pyrimidine metabolism_Homo sapiens_hsa002401.11488284
39Ribosome_Homo sapiens_hsa030101.10228347
40Folate biosynthesis_Homo sapiens_hsa007901.07490348
41Linoleic acid metabolism_Homo sapiens_hsa005911.06793246
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.05892802
43Fanconi anemia pathway_Homo sapiens_hsa034601.04422334
44Butanoate metabolism_Homo sapiens_hsa006501.04380745
45Mismatch repair_Homo sapiens_hsa034301.01190285
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00806154
47Vitamin B6 metabolism_Homo sapiens_hsa007500.98696169
48Purine metabolism_Homo sapiens_hsa002300.97652825
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93647723
50Peroxisome_Homo sapiens_hsa041460.93077919
51Nucleotide excision repair_Homo sapiens_hsa034200.90132878
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90070039
53Arginine and proline metabolism_Homo sapiens_hsa003300.89561075
54Alzheimers disease_Homo sapiens_hsa050100.88428311
55Phototransduction_Homo sapiens_hsa047440.86131848
56Non-homologous end-joining_Homo sapiens_hsa034500.84282390
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83197400
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81630828
59Retinol metabolism_Homo sapiens_hsa008300.80445225
60Regulation of autophagy_Homo sapiens_hsa041400.78855844
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78195291
62mRNA surveillance pathway_Homo sapiens_hsa030150.74761246
63Olfactory transduction_Homo sapiens_hsa047400.73740009
64Legionellosis_Homo sapiens_hsa051340.73673148
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73400585
66Mineral absorption_Homo sapiens_hsa049780.68608768
67Biosynthesis of amino acids_Homo sapiens_hsa012300.66942308
68Metabolic pathways_Homo sapiens_hsa011000.66745957
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66644110
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.64744023
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63725008
72Fatty acid biosynthesis_Homo sapiens_hsa000610.63167636
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.62587585
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59722420
75Ether lipid metabolism_Homo sapiens_hsa005650.58862540
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.58549778
77Measles_Homo sapiens_hsa051620.57416861
78Steroid biosynthesis_Homo sapiens_hsa001000.56505949
79GABAergic synapse_Homo sapiens_hsa047270.56400813
80Tryptophan metabolism_Homo sapiens_hsa003800.56198639
81Hematopoietic cell lineage_Homo sapiens_hsa046400.55580428
82Graft-versus-host disease_Homo sapiens_hsa053320.55291422
83Morphine addiction_Homo sapiens_hsa050320.55080135
84Chemical carcinogenesis_Homo sapiens_hsa052040.55018949
85Glutathione metabolism_Homo sapiens_hsa004800.54177311
86Vitamin digestion and absorption_Homo sapiens_hsa049770.53923576
87Nicotine addiction_Homo sapiens_hsa050330.53435424
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52417802
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47218021
90Primary immunodeficiency_Homo sapiens_hsa053400.45946508
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44245517
92Pyruvate metabolism_Homo sapiens_hsa006200.43078204
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42700434
94T cell receptor signaling pathway_Homo sapiens_hsa046600.42408580
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41229947
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41047067
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40352754
98Rheumatoid arthritis_Homo sapiens_hsa053230.39590791
99Base excision repair_Homo sapiens_hsa034100.39457123
100Arachidonic acid metabolism_Homo sapiens_hsa005900.39245980

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