ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of SSU-rRNA (GO:0030490)	5.54394218
2	gonadal mesoderm development (GO:0007506)	5.39070009
3	maturation of 5.8S rRNA (GO:0000460)	5.37580636
4	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.83730296
5	chaperone-mediated protein transport (GO:0072321)	4.77143986
6	signal peptide processing (GO:0006465)	4.58383759
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.45493526
8	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.42579984
9	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.34243669
10	respiratory chain complex IV assembly (GO:0008535)	4.28761388
11	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.25132456
12	left/right axis specification (GO:0070986)	4.19364425
13	rRNA catabolic process (GO:0016075)	4.12541866
14	ATP synthesis coupled proton transport (GO:0015986)	3.98982328
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.98982328
16	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.94470862
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.90461750
18	cullin deneddylation (GO:0010388)	3.86022256
19	cytochrome complex assembly (GO:0017004)	3.83898354
20	protein neddylation (GO:0045116)	3.78545966
21	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.74854934
22	proteasome assembly (GO:0043248)	3.73351423
23	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.67448657
24	DNA deamination (GO:0045006)	3.65637614
25	regulation of cellular amino acid metabolic process (GO:0006521)	3.59623806
26	protein deneddylation (GO:0000338)	3.58491747
27	GTP biosynthetic process (GO:0006183)	3.58370708
28	respiratory electron transport chain (GO:0022904)	3.57258470
29	electron transport chain (GO:0022900)	3.56566473
30	protein-cofactor linkage (GO:0018065)	3.52624562
31	resolution of meiotic recombination intermediates (GO:0000712)	3.47551182
32	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.45049024
33	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.43406277
34	mannosylation (GO:0097502)	3.42605654
35	epithelial cilium movement (GO:0003351)	3.40904542
36	ncRNA catabolic process (GO:0034661)	3.38365780
37	UTP metabolic process (GO:0046051)	3.34777287
38	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.34225103
39	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.34225103
40	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.34225103
41	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.33404458
42	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.33404458
43	response to pheromone (GO:0019236)	3.30296320
44	histone mRNA metabolic process (GO:0008334)	3.29580734
45	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.29372213
46	negative regulation of ligase activity (GO:0051352)	3.29372213
47	rRNA modification (GO:0000154)	3.27282129
48	heme transport (GO:0015886)	3.26722520
49	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.25643861
50	protein complex biogenesis (GO:0070271)	3.17132458
51	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.16762857
52	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.16762857
53	synapsis (GO:0007129)	3.15390899
54	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.12925837
55	meiotic chromosome segregation (GO:0045132)	3.09464765
56	rRNA methylation (GO:0031167)	3.09462053
57	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.06897694
58	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.06897694
59	hydrogen ion transmembrane transport (GO:1902600)	3.06061777
60	mitochondrial respiratory chain complex assembly (GO:0033108)	3.05913020
61	UTP biosynthetic process (GO:0006228)	3.05350953
62	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.02258072
63	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.01925718
64	water-soluble vitamin biosynthetic process (GO:0042364)	3.01835136
65	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.00209638
66	peptidyl-histidine modification (GO:0018202)	2.97744529
67	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.96392998
68	tRNA aminoacylation (GO:0043039)	2.94470159
69	amino acid activation (GO:0043038)	2.94470159
70	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.94359968
71	RNA phosphodiester bond hydrolysis (GO:0090501)	2.93141376
72	tRNA aminoacylation for protein translation (GO:0006418)	2.92742769
73	base-excision repair, AP site formation (GO:0006285)	2.91320845
74	positive regulation of ligase activity (GO:0051351)	2.87264073
75	ATP biosynthetic process (GO:0006754)	2.84538292
76	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.84034340
77	proton transport (GO:0015992)	2.82839565
78	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.80616909
79	intraciliary transport (GO:0042073)	2.80258331
80	cilium morphogenesis (GO:0060271)	2.80187412
81	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.79602122
82	protein K63-linked deubiquitination (GO:0070536)	2.79299362
83	hydrogen transport (GO:0006818)	2.78327700
84	intracellular protein transmembrane import (GO:0044743)	2.77430649
85	protein localization to cilium (GO:0061512)	2.77292857
86	pteridine-containing compound biosynthetic process (GO:0042559)	2.74800217
87	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.74715391
88	single strand break repair (GO:0000012)	2.74361485
89	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.68355570
90	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.68355570
91	NADH dehydrogenase complex assembly (GO:0010257)	2.68355570
92	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.68080133
93	glycerophospholipid catabolic process (GO:0046475)	2.67621921
94	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.66781855
95	histone mRNA catabolic process (GO:0071044)	2.66775461
96	negative regulation of B cell apoptotic process (GO:0002903)	2.66666211
97	microtubule severing (GO:0051013)	2.66538478
98	CTP biosynthetic process (GO:0006241)	2.66524613
99	CTP metabolic process (GO:0046036)	2.66524613
100	preassembly of GPI anchor in ER membrane (GO:0016254)	2.65452448

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.49905708
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.62894490
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.48045003
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.33571748
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.84467342
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.83433353
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.78317167
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.76687868
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.54339949
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.48437098
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.41487922
12	VDR_22108803_ChIP-Seq_LS180_Human	2.37247432
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.36380478
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.29088648
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.23373764
16	EWS_26573619_Chip-Seq_HEK293_Human	2.19424195
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.12177372
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.11125343
19	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.01026525
20	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.95643815
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.90335771
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.88942231
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.87547008
24	P300_19829295_ChIP-Seq_ESCs_Human	1.86926058
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.82196645
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.81966469
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.78496914
28	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.77484852
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.76999922
30	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.66613721
31	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.59394150
32	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.55177723
33	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.54156369
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46285762
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.45692928
36	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.45099246
37	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.44968235
38	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.41862884
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.40671023
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.38633324
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.36677181
42	FUS_26573619_Chip-Seq_HEK293_Human	1.35771147
43	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.35700167
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.34938146
45	GBX2_23144817_ChIP-Seq_PC3_Human	1.32277917
46	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.30975781
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27635294
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26327938
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26327938
50	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.22838928
51	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22823629
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19306300
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19306300
54	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.17681193
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.17267926
56	AR_20517297_ChIP-Seq_VCAP_Human	1.16413218
57	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13212338
58	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12987710
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12246503
60	TTF2_22483619_ChIP-Seq_HELA_Human	1.11993187
61	HTT_18923047_ChIP-ChIP_STHdh_Human	1.11710021
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.11521995
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.11521995
64	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.10183425
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09887918
66	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.08399773
67	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.08381005
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.07196909
69	ER_23166858_ChIP-Seq_MCF-7_Human	1.06646098
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05130346
71	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.04624677
72	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.04545980
73	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.04271323
74	PHF8_20622853_ChIP-Seq_HELA_Human	1.03547776
75	EZH2_22144423_ChIP-Seq_EOC_Human	1.02937614
76	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.02911307
77	GABP_19822575_ChIP-Seq_HepG2_Human	1.00494453
78	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.99750871
79	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.99392053
80	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.99011129
81	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99011129
82	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98644659
83	P300_18555785_Chip-Seq_ESCs_Mouse	0.98355070
84	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.97499305
85	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97321648
86	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.97257287
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97119859
88	P53_22387025_ChIP-Seq_ESCs_Mouse	0.96704395
89	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.96036379
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.95814924
91	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95698759
92	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.95481908
93	ERG_20517297_ChIP-Seq_VCAP_Human	0.95463807
94	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.95291003
95	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.95185662
96	NCOR_22424771_ChIP-Seq_293T_Human	0.95043195
97	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.93897905
98	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.92924773
99	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.92054994
100	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.91538193

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005408_hypopigmentation	4.15195258
2	MP0002837_dystrophic_cardiac_calcinosis	3.22486028
3	MP0002102_abnormal_ear_morphology	3.16598401
4	MP0003806_abnormal_nucleotide_metabolis	2.91024027
5	MP0002736_abnormal_nociception_after	2.88797262
6	MP0008058_abnormal_DNA_repair	2.61557309
7	MP0004142_abnormal_muscle_tone	2.41711399
8	MP0006292_abnormal_olfactory_placode	2.35768362
9	MP0005075_abnormal_melanosome_morpholog	2.33465048
10	MP0001968_abnormal_touch/_nociception	2.33306076
11	MP0002938_white_spotting	2.19544250
12	MP0008877_abnormal_DNA_methylation	2.19178166
13	MP0009379_abnormal_foot_pigmentation	2.15736087
14	MP0003693_abnormal_embryo_hatching	2.15724455
15	MP0008057_abnormal_DNA_replication	2.10426283
16	MP0002138_abnormal_hepatobiliary_system	2.09697302
17	MP0008875_abnormal_xenobiotic_pharmacok	2.09586895
18	MP0003718_maternal_effect	1.85419588
19	MP0004885_abnormal_endolymph	1.85056017
20	MP0005379_endocrine/exocrine_gland_phen	1.83553976
21	MP0000372_irregular_coat_pigmentation	1.80147690
22	MP0003195_calcinosis	1.80042333
23	MP0002163_abnormal_gland_morphology	1.77514907
24	MP0004147_increased_porphyrin_level	1.74540879
25	MP0005551_abnormal_eye_electrophysiolog	1.70492841
26	MP0008789_abnormal_olfactory_epithelium	1.65648673
27	MP0003880_abnormal_central_pattern	1.63325346
28	MP0005253_abnormal_eye_physiology	1.55370185
29	MP0005084_abnormal_gallbladder_morpholo	1.54390722
30	MP0005248_abnormal_Harderian_gland	1.52274913
31	MP0005671_abnormal_response_to	1.52177408
32	MP0003878_abnormal_ear_physiology	1.34480269
33	MP0005377_hearing/vestibular/ear_phenot	1.34480269
34	MP0002139_abnormal_hepatobiliary_system	1.34158733
35	MP0003646_muscle_fatigue	1.30964809
36	MP0003300_gastrointestinal_ulcer	1.30286367
37	MP0005646_abnormal_pituitary_gland	1.29587817
38	MP0002234_abnormal_pharynx_morphology	1.27642098
39	MP0010030_abnormal_orbit_morphology	1.25326561
40	MP0005645_abnormal_hypothalamus_physiol	1.21923845
41	MP0001984_abnormal_olfaction	1.19043642
42	MP0005636_abnormal_mineral_homeostasis	1.16972272
43	MP0003786_premature_aging	1.16848796
44	MP0002928_abnormal_bile_duct	1.14965633
45	MP0001905_abnormal_dopamine_level	1.14515282
46	MP0001485_abnormal_pinna_reflex	1.14373107
47	MP0004133_heterotaxia	1.13508870
48	MP0006072_abnormal_retinal_apoptosis	1.12725240
49	MP0009745_abnormal_behavioral_response	1.11528978
50	MP0004742_abnormal_vestibular_system	1.10911638
51	MP0005395_other_phenotype	1.10693000
52	MP0003011_delayed_dark_adaptation	1.09433877
53	MP0003252_abnormal_bile_duct	1.09119739
54	MP0001293_anophthalmia	1.08579490
55	MP0005410_abnormal_fertilization	1.08553069
56	MP0008872_abnormal_physiological_respon	1.08174601
57	MP0005332_abnormal_amino_acid	1.03688703
58	MP0006036_abnormal_mitochondrial_physio	1.02813087
59	MP0009046_muscle_twitch	1.02541772
60	MP0005365_abnormal_bile_salt	1.01228685
61	MP0002254_reproductive_system_inflammat	1.00836155
62	MP0005499_abnormal_olfactory_system	0.96250331
63	MP0005394_taste/olfaction_phenotype	0.96250331
64	MP0001486_abnormal_startle_reflex	0.96073992
65	MP0001756_abnormal_urination	0.95977381
66	MP0002272_abnormal_nervous_system	0.95579539
67	MP0002095_abnormal_skin_pigmentation	0.92018002
68	MP0003137_abnormal_impulse_conducting	0.91854357
69	MP0002233_abnormal_nose_morphology	0.91818152
70	MP0002822_catalepsy	0.89575970
71	MP0003136_yellow_coat_color	0.88463679
72	MP0002693_abnormal_pancreas_physiology	0.86887124
73	MP0004019_abnormal_vitamin_homeostasis	0.86173020
74	MP0001764_abnormal_homeostasis	0.83913073
75	MP0001835_abnormal_antigen_presentation	0.82936838
76	MP0005389_reproductive_system_phenotype	0.81355228
77	MP0001963_abnormal_hearing_physiology	0.80808626
78	MP0001986_abnormal_taste_sensitivity	0.79409880
79	MP0008995_early_reproductive_senescence	0.79242420
80	MP0004084_abnormal_cardiac_muscle	0.78380912
81	MP0005195_abnormal_posterior_eye	0.77820837
82	MP0001919_abnormal_reproductive_system	0.77409036
83	MP0002168_other_aberrant_phenotype	0.76664657
84	MP0002638_abnormal_pupillary_reflex	0.76197148
85	MP0004215_abnormal_myocardial_fiber	0.75369617
86	MP0002064_seizures	0.73564215
87	MP0001501_abnormal_sleep_pattern	0.73485649
88	MP0004145_abnormal_muscle_electrophysio	0.72720637
89	MP0003943_abnormal_hepatobiliary_system	0.72481486
90	MP0010094_abnormal_chromosome_stability	0.71885132
91	MP0008007_abnormal_cellular_replicative	0.70562679
92	MP0002067_abnormal_sensory_capabilities	0.70504679
93	MP0000685_abnormal_immune_system	0.70367852
94	MP0001324_abnormal_eye_pigmentation	0.70277147
95	MP0006276_abnormal_autonomic_nervous	0.68639462
96	MP0001186_pigmentation_phenotype	0.68542614
97	MP0000631_abnormal_neuroendocrine_gland	0.68533921
98	MP0003045_fibrosis	0.68484150
99	MP0002210_abnormal_sex_determination	0.67430819
100	MP0003890_abnormal_embryonic-extraembry	0.66260415

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatocellular necrosis (HP:0001404)	4.15175356
2	Acute necrotizing encephalopathy (HP:0006965)	3.84457922
3	Methylmalonic acidemia (HP:0002912)	3.83431874
4	Mitochondrial inheritance (HP:0001427)	3.83219309
5	Decreased central vision (HP:0007663)	3.72986102
6	Methylmalonic aciduria (HP:0012120)	3.71483002
7	Increased CSF lactate (HP:0002490)	3.62077954
8	Acute encephalopathy (HP:0006846)	3.56922703
9	Hepatic necrosis (HP:0002605)	3.54964117
10	Pancreatic fibrosis (HP:0100732)	3.51029702
11	Hypokalemic alkalosis (HP:0001949)	3.45615026
12	Chronic bronchitis (HP:0004469)	3.42848417
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.38968176
14	Pancreatic cysts (HP:0001737)	3.28340775
15	Type I transferrin isoform profile (HP:0003642)	3.22801546
16	Decreased circulating renin level (HP:0003351)	3.11732430
17	Progressive macrocephaly (HP:0004481)	3.09169446
18	Medial flaring of the eyebrow (HP:0010747)	2.97794631
19	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.90919856
20	Bile duct proliferation (HP:0001408)	2.85520719
21	Abnormal biliary tract physiology (HP:0012439)	2.85520719
22	Abnormality of DNA repair (HP:0003254)	2.85242511
23	Reduced antithrombin III activity (HP:0001976)	2.75697675
24	True hermaphroditism (HP:0010459)	2.72183675
25	Abnormality of midbrain morphology (HP:0002418)	2.72174360
26	Molar tooth sign on MRI (HP:0002419)	2.72174360
27	Cerebral edema (HP:0002181)	2.68578569
28	Dyschromatopsia (HP:0007641)	2.64822224
29	Congenital primary aphakia (HP:0007707)	2.64458671
30	Hyperglycinuria (HP:0003108)	2.64016881
31	Chronic hepatic failure (HP:0100626)	2.62978265
32	Hypoproteinemia (HP:0003075)	2.60721444
33	Abnormality of vitamin B metabolism (HP:0004340)	2.58840539
34	Hyperaldosteronism (HP:0000859)	2.56048768
35	Reticulocytopenia (HP:0001896)	2.54182941
36	Gait imbalance (HP:0002141)	2.53492837
37	Supernumerary spleens (HP:0009799)	2.52251633
38	Nephrogenic diabetes insipidus (HP:0009806)	2.52039219
39	CNS demyelination (HP:0007305)	2.51264633
40	Abnormality of the pons (HP:0007361)	2.44911173
41	Abnormal rod and cone electroretinograms (HP:0008323)	2.44788901
42	Hyperactive renin-angiotensin system (HP:0000841)	2.43544260
43	Abnormal protein N-linked glycosylation (HP:0012347)	2.42027923
44	Abnormal protein glycosylation (HP:0012346)	2.42027923
45	Abnormal glycosylation (HP:0012345)	2.42027923
46	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.42027923
47	Postaxial foot polydactyly (HP:0001830)	2.36925027
48	Optic disc pallor (HP:0000543)	2.33833514
49	Hypoplasia of the pons (HP:0012110)	2.32462818
50	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.31962379
51	Chronic diarrhea (HP:0002028)	2.26426686
52	Nephronophthisis (HP:0000090)	2.21312788
53	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.19267639
54	Abnormality of the renal cortex (HP:0011035)	2.19082159
55	Increased serum lactate (HP:0002151)	2.18305481
56	Congenital, generalized hypertrichosis (HP:0004540)	2.18038067
57	Respiratory failure (HP:0002878)	2.16945949
58	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.16857579
59	Meckel diverticulum (HP:0002245)	2.15787238
60	Abnormality of chromosome stability (HP:0003220)	2.15709338
61	Macular degeneration (HP:0000608)	2.14049300
62	Abnormality of the ileum (HP:0001549)	2.12838920
63	Polydipsia (HP:0001959)	2.12033236
64	Abnormal drinking behavior (HP:0030082)	2.12033236
65	Abnormality of serine family amino acid metabolism (HP:0010894)	2.11279642
66	Abnormality of glycine metabolism (HP:0010895)	2.11279642
67	Dysdiadochokinesis (HP:0002075)	2.11016843
68	Central scotoma (HP:0000603)	2.10484520
69	Renal salt wasting (HP:0000127)	2.09423122
70	Megaloblastic anemia (HP:0001889)	2.08647591
71	Poor coordination (HP:0002370)	2.08052915
72	Increased hepatocellular lipid droplets (HP:0006565)	2.07812424
73	Lactic acidosis (HP:0003128)	2.06914724
74	Abnormality of the renal medulla (HP:0100957)	2.04551782
75	Sclerocornea (HP:0000647)	2.02700927
76	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.00333014
77	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.00333014
78	Stomatitis (HP:0010280)	2.00099655
79	Short tibia (HP:0005736)	1.97098467
80	Abnormality of renin-angiotensin system (HP:0000847)	1.96051282
81	Congenital stationary night blindness (HP:0007642)	1.95306303
82	Leukodystrophy (HP:0002415)	1.94348877
83	Duplicated collecting system (HP:0000081)	1.94086352
84	Genital tract atresia (HP:0001827)	1.93379360
85	Glycosuria (HP:0003076)	1.92329118
86	Abnormality of urine glucose concentration (HP:0011016)	1.92329118
87	Abnormality of methionine metabolism (HP:0010901)	1.91114640
88	Adrenal hypoplasia (HP:0000835)	1.87881817
89	Pancytopenia (HP:0001876)	1.87669810
90	Lipid accumulation in hepatocytes (HP:0006561)	1.86753805
91	Emotional lability (HP:0000712)	1.85092815
92	Abnormality of vitamin metabolism (HP:0100508)	1.84385028
93	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.84007203
94	Hyperglycinemia (HP:0002154)	1.83734821
95	Palpitations (HP:0001962)	1.83525240
96	Abnormality of abdominal situs (HP:0011620)	1.82944083
97	Abdominal situs inversus (HP:0003363)	1.82944083
98	Constricted visual fields (HP:0001133)	1.82615973
99	Polyuria (HP:0000103)	1.80160648
100	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.79045710

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	4.58223970
2	EIF2AK3	3.37622892
3	NME1	2.93769325
4	MAP3K9	2.61673558
5	FRK	2.57185686
6	MST4	2.47820478
7	OXSR1	2.44600095
8	EIF2AK1	2.31224267
9	MKNK2	2.08755326
10	TSSK6	2.06123995
11	VRK2	2.01997472
12	NEK1	2.00465486
13	STK39	1.91880845
14	PLK4	1.83243103
15	GRK1	1.77551272
16	WNK4	1.76484961
17	ZAK	1.75165062
18	ACVR1B	1.71848397
19	WNK3	1.65597986
20	CDK19	1.62655782
21	CSNK1G3	1.58075668
22	CSNK1G2	1.54369983
23	NEK9	1.50376778
24	CSNK1A1L	1.46834483
25	PLK3	1.43205023
26	ADRBK2	1.40336105
27	TNIK	1.34001463
28	BUB1	1.30404291
29	PLK2	1.30110071
30	EPHA4	1.29455336
31	INSRR	1.29290267
32	SRPK1	1.29110628
33	BCR	1.27398710
34	CSNK1G1	1.25692386
35	TXK	1.23864585
36	PDK2	1.23785501
37	VRK1	1.16664871
38	CDC7	1.13117145
39	PLK1	1.10051917
40	MAP3K12	1.10021706
41	MAP3K4	1.07290068
42	TIE1	1.06844953
43	NEK2	1.06764411
44	BMPR1B	1.04615607
45	PRKCG	0.98022994
46	PHKG2	0.97975545
47	PHKG1	0.97975545
48	PINK1	0.96272751
49	MKNK1	0.95895355
50	DYRK2	0.90081013
51	TLK1	0.86350079
52	IKBKB	0.85007127
53	TEC	0.84087200
54	BCKDK	0.80213121
55	TNK2	0.77615776
56	PAK3	0.77399119
57	MAPKAPK3	0.77308192
58	ERBB3	0.70242484
59	MAP3K13	0.66260330
60	ATR	0.65479037
61	DAPK2	0.64842030
62	PRKCE	0.64011701
63	EIF2AK2	0.63388903
64	DAPK1	0.59529090
65	NUAK1	0.58494571
66	CSNK2A2	0.57963937
67	ARAF	0.56713518
68	MAP2K7	0.56448990
69	PIK3CG	0.55161960
70	ABL2	0.55141944
71	BMPR2	0.54603223
72	PRKACA	0.50765674
73	IKBKE	0.49520030
74	ERBB4	0.48326540
75	CAMK2A	0.48306431
76	CSNK1E	0.47432529
77	ATM	0.46352651
78	CSNK2A1	0.45304817
79	OBSCN	0.44976990
80	MYLK	0.44767024
81	UHMK1	0.44300820
82	PIM1	0.43195716
83	PRKCA	0.42105814
84	PRKACB	0.41608216
85	STK38L	0.40940167
86	PRKDC	0.40236814
87	STK4	0.39806891
88	CSNK1A1	0.38656697
89	TAF1	0.37584295
90	LYN	0.36876216
91	GRK5	0.36681851
92	WEE1	0.36225894
93	PTK2B	0.34001479
94	AURKB	0.33705244
95	CSNK1D	0.33274208
96	TTK	0.31385370
97	CCNB1	0.30382976
98	STK3	0.28941983
99	MINK1	0.28830725
100	PASK	0.28278895

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.61365885
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.82078652
3	Protein export_Homo sapiens_hsa03060	3.23225229
4	Parkinsons disease_Homo sapiens_hsa05012	2.74994835
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.28800549
6	Homologous recombination_Homo sapiens_hsa03440	2.24087379
7	Propanoate metabolism_Homo sapiens_hsa00640	2.15995561
8	RNA degradation_Homo sapiens_hsa03018	2.14422443
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10916817
10	Alzheimers disease_Homo sapiens_hsa05010	2.08359044
11	Huntingtons disease_Homo sapiens_hsa05016	1.99038593
12	Ribosome_Homo sapiens_hsa03010	1.95370723
13	Basal transcription factors_Homo sapiens_hsa03022	1.82550421
14	One carbon pool by folate_Homo sapiens_hsa00670	1.82202281
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.77778310
16	Sulfur metabolism_Homo sapiens_hsa00920	1.77392225
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.73466122
18	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.68271418
19	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.68035027
20	Caffeine metabolism_Homo sapiens_hsa00232	1.65985529
21	Collecting duct acid secretion_Homo sapiens_hsa04966	1.63026487
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.61187482
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.57733562
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.55621840
25	RNA transport_Homo sapiens_hsa03013	1.55476565
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.51763186
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.48084799
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.46889619
29	Mismatch repair_Homo sapiens_hsa03430	1.46178385
30	Asthma_Homo sapiens_hsa05310	1.45162237
31	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.41859302
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.39271264
33	Non-homologous end-joining_Homo sapiens_hsa03450	1.39183193
34	beta-Alanine metabolism_Homo sapiens_hsa00410	1.26547611
35	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.24987150
36	Arginine and proline metabolism_Homo sapiens_hsa00330	1.20354783
37	Histidine metabolism_Homo sapiens_hsa00340	1.18349964
38	Folate biosynthesis_Homo sapiens_hsa00790	1.13453743
39	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.12880303
40	Nitrogen metabolism_Homo sapiens_hsa00910	1.09950815
41	RNA polymerase_Homo sapiens_hsa03020	1.07511568
42	Nucleotide excision repair_Homo sapiens_hsa03420	1.07076933
43	Fatty acid elongation_Homo sapiens_hsa00062	1.02852648
44	Ether lipid metabolism_Homo sapiens_hsa00565	1.01810504
45	DNA replication_Homo sapiens_hsa03030	0.99220112
46	Type I diabetes mellitus_Homo sapiens_hsa04940	0.99135895
47	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.98047276
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.97633962
49	Spliceosome_Homo sapiens_hsa03040	0.97509453
50	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.95444822
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.92369685
52	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.88078529
53	Phototransduction_Homo sapiens_hsa04744	0.84044812
54	Taste transduction_Homo sapiens_hsa04742	0.83559301
55	Peroxisome_Homo sapiens_hsa04146	0.83277343
56	Pyruvate metabolism_Homo sapiens_hsa00620	0.83247181
57	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.82199563
58	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.82181349
59	Metabolic pathways_Homo sapiens_hsa01100	0.80562167
60	Fatty acid degradation_Homo sapiens_hsa00071	0.79456458
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.78677094
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.78362164
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.78021313
64	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.78017583
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.69095523
66	Base excision repair_Homo sapiens_hsa03410	0.67636216
67	Pyrimidine metabolism_Homo sapiens_hsa00240	0.66955071
68	Glutathione metabolism_Homo sapiens_hsa00480	0.66223908
69	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.65870474
70	Allograft rejection_Homo sapiens_hsa05330	0.65816965
71	Purine metabolism_Homo sapiens_hsa00230	0.62792370
72	Butanoate metabolism_Homo sapiens_hsa00650	0.62565065
73	Nicotine addiction_Homo sapiens_hsa05033	0.60731406
74	Rheumatoid arthritis_Homo sapiens_hsa05323	0.59045912
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56135515
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55054918
77	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.53081145
78	Vibrio cholerae infection_Homo sapiens_hsa05110	0.51506951
79	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.49011862
80	Olfactory transduction_Homo sapiens_hsa04740	0.48879319
81	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.47480112
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46952532
83	Fatty acid metabolism_Homo sapiens_hsa01212	0.46295989
84	GABAergic synapse_Homo sapiens_hsa04727	0.44723710
85	Graft-versus-host disease_Homo sapiens_hsa05332	0.43653836
86	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43607359
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37960108
88	Mineral absorption_Homo sapiens_hsa04978	0.37198098
89	Regulation of autophagy_Homo sapiens_hsa04140	0.37059045
90	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.36222140
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35944681
92	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.33253569
93	Retinol metabolism_Homo sapiens_hsa00830	0.33056713
94	Morphine addiction_Homo sapiens_hsa05032	0.32903225
95	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.32680909
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.32639685
97	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.31626809
98	PPAR signaling pathway_Homo sapiens_hsa03320	0.31156923
99	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.25818626
100	Selenocompound metabolism_Homo sapiens_hsa00450	0.24437664

HSPD1P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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