HSPE1-MOB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring HSPE1 (heat shock 10kDa protein 1 (chaperonin 10)) and MOB4 (MOB family member 4, phocein) genes on chromosome 2. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.62489931
2cullin deneddylation (GO:0010388)5.37662465
3DNA double-strand break processing (GO:0000729)5.11187169
4protein deneddylation (GO:0000338)5.06724890
5negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.58222849
6regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.49743442
7DNA damage response, detection of DNA damage (GO:0042769)4.48786276
8positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.38207721
9regulation of cellular amino acid metabolic process (GO:0006521)4.28320945
10anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.22891164
11negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.13143028
12negative regulation of ligase activity (GO:0051352)4.13143028
13DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.12934091
14signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.05580542
15signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.05580542
16signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.05580542
17signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.04100241
18intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.04100241
19CENP-A containing nucleosome assembly (GO:0034080)3.96454083
20chromatin remodeling at centromere (GO:0031055)3.90119636
21signal transduction involved in cell cycle checkpoint (GO:0072395)3.87695273
22signal transduction involved in DNA damage checkpoint (GO:0072422)3.87292523
23signal transduction involved in DNA integrity checkpoint (GO:0072401)3.87292523
24respiratory chain complex IV assembly (GO:0008535)3.86171197
25DNA replication-dependent nucleosome assembly (GO:0006335)3.75654521
26DNA replication-dependent nucleosome organization (GO:0034723)3.75654521
27positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.74081506
28regulation of mitotic spindle checkpoint (GO:1903504)3.66002921
29regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.66002921
30positive regulation of ligase activity (GO:0051351)3.59307724
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.57374806
32RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.57374806
33establishment of integrated proviral latency (GO:0075713)3.54342521
34ribosome assembly (GO:0042255)3.51967453
35DNA catabolic process, exonucleolytic (GO:0000738)3.51806532
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.49642422
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.48814693
38protein neddylation (GO:0045116)3.48753325
39DNA ligation (GO:0006266)3.40227228
40regulation of ubiquitin-protein transferase activity (GO:0051438)3.39444051
41IMP biosynthetic process (GO:0006188)3.36691546
42somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.36342173
43isotype switching (GO:0045190)3.36342173
44somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.36342173
45regulation of helicase activity (GO:0051095)3.35058648
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.33950215
47histone exchange (GO:0043486)3.33412321
48DNA deamination (GO:0045006)3.30906660
49regulation of ligase activity (GO:0051340)3.28498005
50purine nucleobase biosynthetic process (GO:0009113)3.23167456
51histone mRNA metabolic process (GO:0008334)3.21358223
52non-recombinational repair (GO:0000726)3.19931587
53double-strand break repair via nonhomologous end joining (GO:0006303)3.19931587
54DNA replication checkpoint (GO:0000076)3.19368484
55negative regulation of DNA-dependent DNA replication (GO:2000104)3.18475722
56cytochrome complex assembly (GO:0017004)3.16215617
57tRNA aminoacylation for protein translation (GO:0006418)3.13699801
58DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.13563711
59histone H2A acetylation (GO:0043968)3.12658706
60peptidyl-histidine modification (GO:0018202)3.09961501
61negative regulation of protein ubiquitination (GO:0031397)3.09382906
62regulation of cellular amine metabolic process (GO:0033238)3.09022597
63amino acid activation (GO:0043038)3.08656375
64tRNA aminoacylation (GO:0043039)3.08656375
65lactate metabolic process (GO:0006089)3.06013423
66dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.05095872
67L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.05081298
68establishment of viral latency (GO:0019043)3.04914382
69response to pheromone (GO:0019236)3.02777719
70positive regulation of cell cycle arrest (GO:0071158)3.01025755
71organelle disassembly (GO:1903008)3.00847986
72branched-chain amino acid catabolic process (GO:0009083)2.96406253
73mitotic metaphase plate congression (GO:0007080)2.96299245
74platelet dense granule organization (GO:0060155)2.95936395
75antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.95602318
76attachment of spindle microtubules to kinetochore (GO:0008608)2.94758739
77nucleobase biosynthetic process (GO:0046112)2.94337013
78response to X-ray (GO:0010165)2.92738538
79DNA replication-independent nucleosome assembly (GO:0006336)2.92381771
80DNA replication-independent nucleosome organization (GO:0034724)2.92381771
81cell cycle G1/S phase transition (GO:0044843)2.89543583
82G1/S transition of mitotic cell cycle (GO:0000082)2.89543583
83negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.88695462
84maturation of 5.8S rRNA (GO:0000460)2.87384401
85RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.87380051
86postreplication repair (GO:0006301)2.84950395
87water-soluble vitamin biosynthetic process (GO:0042364)2.83147823
88IMP metabolic process (GO:0046040)2.81457618
89mitochondrial RNA metabolic process (GO:0000959)2.81306817
90mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.81272894
91somatic hypermutation of immunoglobulin genes (GO:0016446)2.78724466
92somatic diversification of immune receptors via somatic mutation (GO:0002566)2.78724466
93transcription elongation from RNA polymerase III promoter (GO:0006385)2.77567135
94termination of RNA polymerase III transcription (GO:0006386)2.77567135
95tRNA metabolic process (GO:0006399)2.75922937
96protein complex biogenesis (GO:0070271)2.74944223
97protein localization to kinetochore (GO:0034501)2.74364951
98spindle checkpoint (GO:0031577)2.73692051
99signal transduction in response to DNA damage (GO:0042770)2.72809198
100protein K11-linked ubiquitination (GO:0070979)2.72770180

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.02020964
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.13091842
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.59977903
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.40560957
5E2F7_22180533_ChIP-Seq_HELA_Human3.24542967
6ELK1_19687146_ChIP-ChIP_HELA_Human2.99103321
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91221634
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91157808
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.85307843
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.80470048
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72943153
12VDR_23849224_ChIP-Seq_CD4+_Human2.58242718
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56553350
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50201863
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.49031324
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37094668
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35694650
18ZNF274_21170338_ChIP-Seq_K562_Hela2.30492160
19FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.22101229
20FOXP3_21729870_ChIP-Seq_TREG_Human2.17487581
21PADI4_21655091_ChIP-ChIP_MCF-7_Human2.13338852
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00109257
23DCP1A_22483619_ChIP-Seq_HELA_Human1.97548314
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94440939
25IGF1R_20145208_ChIP-Seq_DFB_Human1.93090111
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.93031380
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.92441290
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.89467156
29EWS_26573619_Chip-Seq_HEK293_Human1.89000953
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87669469
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87086451
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.80652085
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76487817
34VDR_22108803_ChIP-Seq_LS180_Human1.70571545
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70096904
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68611555
37GABP_19822575_ChIP-Seq_HepG2_Human1.67738467
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62878323
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61735393
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61727382
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54973586
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48463399
43MYC_18940864_ChIP-ChIP_HL60_Human1.43274596
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42718250
45FUS_26573619_Chip-Seq_HEK293_Human1.41280822
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.38977491
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37361572
48P300_19829295_ChIP-Seq_ESCs_Human1.36732457
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35296162
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33795715
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33422370
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30152861
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29771325
54AR_21909140_ChIP-Seq_LNCAP_Human1.29497124
55IRF1_19129219_ChIP-ChIP_H3396_Human1.27472038
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22271473
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20948114
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18225862
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16753688
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14134438
61TAF15_26573619_Chip-Seq_HEK293_Human1.12773168
62ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12681753
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12643200
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.11070614
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.09962810
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09676297
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.09362776
68TTF2_22483619_ChIP-Seq_HELA_Human1.09280295
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09024013
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08438228
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07734961
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05577733
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01293904
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.00586033
75CBP_20019798_ChIP-Seq_JUKART_Human1.00029608
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00029608
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99562815
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99499298
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98176067
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97948370
81SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97899010
82CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97071042
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96233890
84TP53_22573176_ChIP-Seq_HFKS_Human0.94031684
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93331255
86PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92943128
87NFE2_27457419_Chip-Seq_LIVER_Mouse0.91910119
88SALL4_22934838_ChIP-ChIP_CD34+_Human0.91681353
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91586004
90NANOG_19829295_ChIP-Seq_ESCs_Human0.90688661
91SOX2_19829295_ChIP-Seq_ESCs_Human0.90688661
92HTT_18923047_ChIP-ChIP_STHdh_Human0.89711457
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89611427
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89527178
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88848788
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.88813280
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88354780
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86678731
99TFEB_21752829_ChIP-Seq_HELA_Human0.85213123
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83850669

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.41630634
2MP0010094_abnormal_chromosome_stability3.74601399
3MP0002102_abnormal_ear_morphology3.57170158
4MP0008877_abnormal_DNA_methylation2.97140461
5MP0003693_abnormal_embryo_hatching2.88274764
6MP0006054_spinal_hemorrhage2.86587176
7MP0003806_abnormal_nucleotide_metabolis2.81797796
8MP0003718_maternal_effect2.80823936
9MP0004957_abnormal_blastocyst_morpholog2.70540765
10MP0003786_premature_aging2.62139135
11MP0000372_irregular_coat_pigmentation2.52624673
12MP0009697_abnormal_copulation2.45415955
13MP0003111_abnormal_nucleus_morphology2.44833673
14MP0000516_abnormal_urinary_system2.34753091
15MP0005367_renal/urinary_system_phenotyp2.34753091
16MP0005084_abnormal_gallbladder_morpholo2.29678657
17MP0008789_abnormal_olfactory_epithelium2.22646668
18MP0003077_abnormal_cell_cycle2.10645194
19MP0002254_reproductive_system_inflammat2.10448734
20MP0003195_calcinosis2.10097625
21MP0008932_abnormal_embryonic_tissue2.09717194
22MP0008057_abnormal_DNA_replication2.07593662
23MP0001529_abnormal_vocalization2.06170119
24MP0006072_abnormal_retinal_apoptosis2.00146916
25MP0008995_early_reproductive_senescence1.91752265
26MP0006035_abnormal_mitochondrial_morpho1.91391515
27MP0003941_abnormal_skin_development1.89528942
28MP0006036_abnormal_mitochondrial_physio1.89280384
29MP0008007_abnormal_cellular_replicative1.89251507
30MP0003186_abnormal_redox_activity1.87571670
31MP0003950_abnormal_plasma_membrane1.78536009
32MP0003890_abnormal_embryonic-extraembry1.76219102
33MP0005394_taste/olfaction_phenotype1.70092802
34MP0005499_abnormal_olfactory_system1.70092802
35MP0003121_genomic_imprinting1.64906516
36MP0005075_abnormal_melanosome_morpholog1.53075631
37MP0002736_abnormal_nociception_after1.48754286
38MP0005645_abnormal_hypothalamus_physiol1.47074823
39MP0005253_abnormal_eye_physiology1.45039264
40MP0003567_abnormal_fetal_cardiomyocyte1.42569807
41MP0002751_abnormal_autonomic_nervous1.41791387
42MP0003221_abnormal_cardiomyocyte_apopto1.36984444
43MP0002090_abnormal_vision1.33381782
44MP0003880_abnormal_central_pattern1.29974379
45MP0006292_abnormal_olfactory_placode1.28832777
46MP0001984_abnormal_olfaction1.25587018
47MP0001929_abnormal_gametogenesis1.23098719
48MP0003122_maternal_imprinting1.22827369
49MP0000358_abnormal_cell_content/1.16342765
50MP0004215_abnormal_myocardial_fiber1.14633559
51MP0000647_abnormal_sebaceous_gland1.11757102
52MP0002210_abnormal_sex_determination1.11035535
53MP0002938_white_spotting1.10423801
54MP0005395_other_phenotype1.09558537
55MP0001119_abnormal_female_reproductive1.07789033
56MP0003119_abnormal_digestive_system1.07054130
57MP0001293_anophthalmia1.05293551
58MP0004147_increased_porphyrin_level1.04786168
59MP0001764_abnormal_homeostasis1.04576291
60MP0004133_heterotaxia1.03328122
61MP0002837_dystrophic_cardiac_calcinosis1.02483535
62MP0000653_abnormal_sex_gland1.02189160
63MP0002234_abnormal_pharynx_morphology1.01893161
64MP0001145_abnormal_male_reproductive0.98180101
65MP0008875_abnormal_xenobiotic_pharmacok0.97665162
66MP0000639_abnormal_adrenal_gland0.91983437
67MP0003011_delayed_dark_adaptation0.91044703
68MP0001730_embryonic_growth_arrest0.89674604
69MP0003937_abnormal_limbs/digits/tail_de0.87467874
70MP0002233_abnormal_nose_morphology0.86770410
71MP0009046_muscle_twitch0.86727315
72MP0005410_abnormal_fertilization0.85058250
73MP0005551_abnormal_eye_electrophysiolog0.81292795
74MP0005380_embryogenesis_phenotype0.79593192
75MP0001672_abnormal_embryogenesis/_devel0.79593192
76MP0005408_hypopigmentation0.78012375
77MP0002163_abnormal_gland_morphology0.76989163
78MP0000749_muscle_degeneration0.76705206
79MP0001697_abnormal_embryo_size0.76688234
80MP0008872_abnormal_physiological_respon0.75718699
81MP0005671_abnormal_response_to0.75583779
82MP0010307_abnormal_tumor_latency0.74855294
83MP0005379_endocrine/exocrine_gland_phen0.73232415
84MP0001177_atelectasis0.72590014
85MP0002084_abnormal_developmental_patter0.72049051
86MP0005647_abnormal_sex_gland0.69886744
87MP0002006_tumorigenesis0.68303036
88MP0001188_hyperpigmentation0.67813729
89MP0003698_abnormal_male_reproductive0.63396624
90MP0003137_abnormal_impulse_conducting0.63028599
91MP0001919_abnormal_reproductive_system0.62602334
92MP0002080_prenatal_lethality0.62505920
93MP0004197_abnormal_fetal_growth/weight/0.61669453
94MP0005332_abnormal_amino_acid0.61228335
95MP0001986_abnormal_taste_sensitivity0.60743575
96MP0000350_abnormal_cell_proliferation0.59207815
97MP0002085_abnormal_embryonic_tissue0.58192921
98MP0005389_reproductive_system_phenotype0.58164331
99MP0000313_abnormal_cell_death0.58065761
100MP0003787_abnormal_imprinting0.56347178

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.52035321
2Abnormality of the labia minora (HP:0012880)3.41278891
3Acute encephalopathy (HP:0006846)3.31428647
4Progressive macrocephaly (HP:0004481)3.18693547
5Hepatocellular necrosis (HP:0001404)3.17496511
6Increased CSF lactate (HP:0002490)3.10099851
7Abnormal mitochondria in muscle tissue (HP:0008316)3.05358690
8Mitochondrial inheritance (HP:0001427)3.04778771
9Increased serum pyruvate (HP:0003542)2.99466555
10Hepatic necrosis (HP:0002605)2.96036617
11Type I transferrin isoform profile (HP:0003642)2.91467616
12Methylmalonic acidemia (HP:0002912)2.80598144
13Abnormality of glycolysis (HP:0004366)2.77151851
14Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.66689224
15Abnormal protein N-linked glycosylation (HP:0012347)2.66689224
16Abnormal protein glycosylation (HP:0012346)2.66689224
17Abnormal glycosylation (HP:0012345)2.66689224
18Meckel diverticulum (HP:0002245)2.63230534
19Abnormality of the ileum (HP:0001549)2.54881188
20Abnormal lung lobation (HP:0002101)2.54338322
21Abnormality of chromosome stability (HP:0003220)2.51017361
22Cerebral edema (HP:0002181)2.49628619
23Increased serum lactate (HP:0002151)2.47773272
24Median cleft lip (HP:0000161)2.46309233
25Amniotic constriction ring (HP:0009775)2.45901182
26Abnormality of placental membranes (HP:0011409)2.45901182
27Ependymoma (HP:0002888)2.42589133
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.42413715
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.42413715
30Increased hepatocellular lipid droplets (HP:0006565)2.37892961
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.37678953
32Prominent metopic ridge (HP:0005487)2.33764374
33Methylmalonic aciduria (HP:0012120)2.25834686
34Renal cortical cysts (HP:0000803)2.25335081
353-Methylglutaconic aciduria (HP:0003535)2.24520362
36Lactic acidosis (HP:0003128)2.23695022
37Duodenal stenosis (HP:0100867)2.23513872
38Small intestinal stenosis (HP:0012848)2.23513872
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22416859
40Reduced antithrombin III activity (HP:0001976)2.20183474
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20030992
42Abnormality of alanine metabolism (HP:0010916)2.20030992
43Hyperalaninemia (HP:0003348)2.20030992
44Colon cancer (HP:0003003)2.19932396
45Abnormality of methionine metabolism (HP:0010901)2.18027133
46Abnormality of the metopic suture (HP:0005556)2.16411045
47Aplasia/hypoplasia of the uterus (HP:0008684)2.15952288
48Abnormality of the preputium (HP:0100587)2.15301208
49Abnormality of the anterior horn cell (HP:0006802)2.14757882
50Degeneration of anterior horn cells (HP:0002398)2.14757882
51Aplastic anemia (HP:0001915)2.13970036
52Medial flaring of the eyebrow (HP:0010747)2.13912689
53Chromsome breakage (HP:0040012)2.13358241
54Pancreatic islet-cell hyperplasia (HP:0004510)2.11917067
55Neoplasm of the adrenal gland (HP:0100631)2.11405841
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11184208
57Lipid accumulation in hepatocytes (HP:0006561)2.09504906
58Hypothermia (HP:0002045)2.06643775
59Intestinal atresia (HP:0011100)2.06331685
60Short tibia (HP:0005736)2.05701444
61Respiratory failure (HP:0002878)2.05673961
62Rhabdomyosarcoma (HP:0002859)2.02804499
63Abnormality of the duodenum (HP:0002246)2.01889434
64Postnatal microcephaly (HP:0005484)2.00724998
65Volvulus (HP:0002580)1.99836257
66Abnormality of serum amino acid levels (HP:0003112)1.99453939
67Cerebral hypomyelination (HP:0006808)1.96954098
68Embryonal renal neoplasm (HP:0011794)1.96544949
69Adrenal hypoplasia (HP:0000835)1.94811669
70Gonadotropin excess (HP:0000837)1.93070290
71Type 2 muscle fiber atrophy (HP:0003554)1.92497398
72Hypoglycemic coma (HP:0001325)1.92162596
73CNS demyelination (HP:0007305)1.91883121
74Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91203947
75Progressive inability to walk (HP:0002505)1.89562405
76Nephroblastoma (Wilms tumor) (HP:0002667)1.88651641
77Bifid tongue (HP:0010297)1.88021697
78Hypoplastic pelvis (HP:0008839)1.87438877
79Lethargy (HP:0001254)1.86040640
80Renal Fanconi syndrome (HP:0001994)1.85757355
81Aplasia/Hypoplasia of the tibia (HP:0005772)1.85228905
82Dyschromatopsia (HP:0007641)1.85180202
83Medulloblastoma (HP:0002885)1.83220587
84Astrocytoma (HP:0009592)1.82960329
85Abnormality of the astrocytes (HP:0100707)1.82960329
86Glioma (HP:0009733)1.82516654
87Microvesicular hepatic steatosis (HP:0001414)1.82449553
88Ovarian neoplasm (HP:0100615)1.81895710
89Pancreatic cysts (HP:0001737)1.81730735
90Poor suck (HP:0002033)1.81620340
91Atrophy/Degeneration involving motor neurons (HP:0007373)1.79523043
92Congenital primary aphakia (HP:0007707)1.79404490
93Hypoglycemic seizures (HP:0002173)1.77750320
94Spastic diplegia (HP:0001264)1.77715146
95Hyperglycinemia (HP:0002154)1.77447383
96Supernumerary spleens (HP:0009799)1.75277076
97Exertional dyspnea (HP:0002875)1.74424910
98Abnormality of the pons (HP:0007361)1.72574583
99Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72393122
100Abnormality of the fovea (HP:0000493)1.71593453

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.73265481
2MST43.61296705
3EIF2AK33.13405528
4BUB13.12629298
5TSSK62.83096521
6MAP4K22.79991442
7SRPK12.71352078
8NEK12.65071344
9NUAK12.54605460
10PBK2.33157708
11WNK32.16833286
12BCR2.07719425
13MAP3K122.06435356
14EIF2AK12.06238730
15PLK32.02122640
16PLK41.88751510
17ZAK1.78230511
18BMPR1B1.77294117
19VRK21.76506650
20TTK1.73345832
21ERBB31.72736486
22FRK1.67627058
23PLK21.67043324
24SIK31.62574809
25BCKDK1.42294403
26WEE11.41486674
27VRK11.37280715
28CSNK1G31.36477893
29FER1.34469958
30CSNK1G11.33383655
31MKNK21.32365643
32MKNK11.30900796
33CDK191.29548358
34CSNK1A1L1.22671256
35INSRR1.17797009
36PLK11.17541563
37CSNK1G21.17507811
38CCNB11.16644943
39STK161.16361025
40ACVR1B1.16176378
41MAP2K71.06541567
42TIE11.01297990
43TAOK30.95117018
44CDC70.94964755
45MAP3K40.94688912
46DAPK10.94460585
47BRSK20.93102566
48GRK10.93024596
49EIF2AK20.92137616
50PDK20.91382629
51LIMK10.91256020
52BMPR20.88228098
53TNIK0.87262701
54MYLK0.83519284
55ERBB40.80736004
56OXSR10.79961953
57MAPK130.77503899
58PAK40.76742856
59PINK10.69627634
60ADRBK20.67443732
61MINK10.66805079
62ATR0.63514825
63KDR0.61558315
64PRKCE0.59407610
65FLT30.59251744
66DYRK20.58562964
67TESK10.55037837
68AURKB0.54136028
69NME20.53979740
70BRSK10.50837717
71TGFBR10.50538619
72ATM0.48531094
73STK100.48476576
74STK390.45334493
75CHEK20.44366423
76FES0.43919120
77CSNK2A10.43655461
78MUSK0.41787185
79STK30.39722021
80MAP3K50.38965963
81CSNK1A10.38740331
82TXK0.38432585
83NME10.37074930
84PAK30.36140244
85SCYL20.35231535
86TLK10.34236848
87EGFR0.33155771
88TESK20.32902781
89GRK70.32169539
90FGFR10.31053242
91STK38L0.30518825
92CAMK2D0.30093989
93CHEK10.29057244
94TEC0.28784392
95TAF10.28713207
96CSNK2A20.28456853
97PRKCI0.28405712
98ILK0.28395786
99PASK0.28142690
100RPS6KA40.26305783

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.20668922
2Protein export_Homo sapiens_hsa030603.51875945
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.83701599
4Non-homologous end-joining_Homo sapiens_hsa034502.65511352
5Mismatch repair_Homo sapiens_hsa034302.63524601
6RNA polymerase_Homo sapiens_hsa030202.36979837
7Homologous recombination_Homo sapiens_hsa034402.36815678
8Steroid biosynthesis_Homo sapiens_hsa001002.31161642
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.22970997
10Oxidative phosphorylation_Homo sapiens_hsa001902.18103495
11Propanoate metabolism_Homo sapiens_hsa006402.15350123
12Basal transcription factors_Homo sapiens_hsa030222.14579717
13DNA replication_Homo sapiens_hsa030302.13451076
14Fatty acid elongation_Homo sapiens_hsa000622.03068260
15Fanconi anemia pathway_Homo sapiens_hsa034602.02872565
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02634763
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98939827
18Parkinsons disease_Homo sapiens_hsa050121.97431629
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91851963
20RNA transport_Homo sapiens_hsa030131.91287252
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79467796
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78258027
23RNA degradation_Homo sapiens_hsa030181.69309030
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.66262448
25Nucleotide excision repair_Homo sapiens_hsa034201.58022380
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53724663
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.52108045
28One carbon pool by folate_Homo sapiens_hsa006701.51639616
29Base excision repair_Homo sapiens_hsa034101.46441953
30Spliceosome_Homo sapiens_hsa030401.45329274
31Pyrimidine metabolism_Homo sapiens_hsa002401.36837043
32Pyruvate metabolism_Homo sapiens_hsa006201.33102982
33Cell cycle_Homo sapiens_hsa041101.24116990
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23351527
35Huntingtons disease_Homo sapiens_hsa050161.21621391
36Glutathione metabolism_Homo sapiens_hsa004801.21518656
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19987592
38Purine metabolism_Homo sapiens_hsa002301.09138945
39Asthma_Homo sapiens_hsa053101.08354330
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02457999
41Selenocompound metabolism_Homo sapiens_hsa004501.02433913
42Alzheimers disease_Homo sapiens_hsa050101.00879774
43Oocyte meiosis_Homo sapiens_hsa041141.00039218
44Caffeine metabolism_Homo sapiens_hsa002320.94178731
45Carbon metabolism_Homo sapiens_hsa012000.93353761
46Sulfur metabolism_Homo sapiens_hsa009200.93225347
47Butanoate metabolism_Homo sapiens_hsa006500.92955945
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92077155
49Phototransduction_Homo sapiens_hsa047440.91058598
50Collecting duct acid secretion_Homo sapiens_hsa049660.89312211
51Peroxisome_Homo sapiens_hsa041460.89030516
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85705364
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84857838
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84136063
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83483612
56p53 signaling pathway_Homo sapiens_hsa041150.83237556
57Vitamin B6 metabolism_Homo sapiens_hsa007500.83229456
58Type I diabetes mellitus_Homo sapiens_hsa049400.77451490
59Regulation of autophagy_Homo sapiens_hsa041400.75653563
60Biosynthesis of amino acids_Homo sapiens_hsa012300.71969853
61Metabolic pathways_Homo sapiens_hsa011000.67939678
62mRNA surveillance pathway_Homo sapiens_hsa030150.65056145
63N-Glycan biosynthesis_Homo sapiens_hsa005100.64797878
64Fatty acid metabolism_Homo sapiens_hsa012120.62811217
65Rheumatoid arthritis_Homo sapiens_hsa053230.62648088
66Folate biosynthesis_Homo sapiens_hsa007900.62117653
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61163756
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59484637
69Legionellosis_Homo sapiens_hsa051340.59211176
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59158074
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58325514
72beta-Alanine metabolism_Homo sapiens_hsa004100.57974411
73Allograft rejection_Homo sapiens_hsa053300.57005297
74Tryptophan metabolism_Homo sapiens_hsa003800.52836521
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48508287
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.47386885
77Vibrio cholerae infection_Homo sapiens_hsa051100.46922433
78Autoimmune thyroid disease_Homo sapiens_hsa053200.46681330
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44751268
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.44704812
81Epstein-Barr virus infection_Homo sapiens_hsa051690.44264548
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44204360
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42473549
84Graft-versus-host disease_Homo sapiens_hsa053320.40852980
85Fatty acid degradation_Homo sapiens_hsa000710.40559211
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38518840
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.35648428
88Antigen processing and presentation_Homo sapiens_hsa046120.33430168
89Viral myocarditis_Homo sapiens_hsa054160.31143322
90Chemical carcinogenesis_Homo sapiens_hsa052040.25695021
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24966196
92TGF-beta signaling pathway_Homo sapiens_hsa043500.24435483
93Herpes simplex infection_Homo sapiens_hsa051680.21563057
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21389209
95Arginine and proline metabolism_Homo sapiens_hsa003300.20512389
96Systemic lupus erythematosus_Homo sapiens_hsa053220.19838805
97Olfactory transduction_Homo sapiens_hsa047400.19688505
98Nitrogen metabolism_Homo sapiens_hsa009100.19454089
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18516153
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16324221

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