ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.68757739
2	ATP synthesis coupled proton transport (GO:0015986)	5.88237203
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.88237203
4	protein neddylation (GO:0045116)	5.78165075
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.70725977
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.62642968
7	cytidine deamination (GO:0009972)	5.55792705
8	cytidine metabolic process (GO:0046087)	5.55792705
9	cytidine catabolic process (GO:0006216)	5.55792705
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.97417013
11	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.93634158
12	respiratory electron transport chain (GO:0022904)	4.75114727
13	electron transport chain (GO:0022900)	4.69078903
14	chaperone-mediated protein transport (GO:0072321)	4.40504043
15	protein complex biogenesis (GO:0070271)	4.40339788
16	ribosomal small subunit biogenesis (GO:0042274)	4.38497223
17	ribosomal small subunit assembly (GO:0000028)	4.18410129
18	maturation of SSU-rRNA (GO:0030490)	4.13441018
19	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.09337147
20	NADH dehydrogenase complex assembly (GO:0010257)	4.09337147
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.09337147
22	positive regulation of T cell apoptotic process (GO:0070234)	4.03696070
23	mitochondrial respiratory chain complex assembly (GO:0033108)	3.99084042
24	viral transcription (GO:0019083)	3.96860021
25	translational termination (GO:0006415)	3.82169305
26	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.81042220
27	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.77900490
28	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.77900490
29	hypothalamus development (GO:0021854)	3.75883783
30	behavioral response to nicotine (GO:0035095)	3.65131756
31	cotranslational protein targeting to membrane (GO:0006613)	3.59083134
32	protein targeting to ER (GO:0045047)	3.58133765
33	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.57767050
34	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.53966559
35	translational elongation (GO:0006414)	3.48862135
36	protein localization to endoplasmic reticulum (GO:0070972)	3.45715000
37	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.42890654
38	ubiquinone biosynthetic process (GO:0006744)	3.40074529
39	hydrogen ion transmembrane transport (GO:1902600)	3.33771636
40	GTP biosynthetic process (GO:0006183)	3.31722407
41	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.25498821
42	response to pheromone (GO:0019236)	3.24452111
43	ATP biosynthetic process (GO:0006754)	3.23533478
44	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.22917306
45	ubiquinone metabolic process (GO:0006743)	3.21799218
46	proton transport (GO:0015992)	3.16278980
47	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.13583609
48	sequestering of actin monomers (GO:0042989)	3.11586048
49	hydrogen transport (GO:0006818)	3.08893905
50	pyrimidine nucleotide catabolic process (GO:0006244)	3.07326634
51	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.05001720
52	pyrimidine nucleobase catabolic process (GO:0006208)	3.04464458
53	DNA demethylation (GO:0080111)	3.01221590
54	cellular component biogenesis (GO:0044085)	3.00226434
55	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.97752907
56	translation (GO:0006412)	2.96717851
57	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.96584745
58	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.96131202
59	proteasome assembly (GO:0043248)	2.95447615
60	negative regulation of B cell apoptotic process (GO:0002903)	2.92287049
61	cellular protein complex disassembly (GO:0043624)	2.90944423
62	negative regulation of T cell differentiation in thymus (GO:0033085)	2.89166033
63	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.86567716
64	viral life cycle (GO:0019058)	2.85500004
65	pyrimidine-containing compound catabolic process (GO:0072529)	2.85167043
66	respiratory chain complex IV assembly (GO:0008535)	2.82412445
67	ovulation cycle (GO:0042698)	2.81654347
68	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.79708702
69	termination of RNA polymerase III transcription (GO:0006386)	2.79708702
70	tRNA processing (GO:0008033)	2.78199801
71	UTP biosynthetic process (GO:0006228)	2.77955159
72	protein-cofactor linkage (GO:0018065)	2.76470396
73	quinone biosynthetic process (GO:1901663)	2.75732965
74	ribosomal large subunit biogenesis (GO:0042273)	2.75233587
75	positive regulation of protein homodimerization activity (GO:0090073)	2.74171213
76	water-soluble vitamin biosynthetic process (GO:0042364)	2.72268620
77	DNA dealkylation (GO:0035510)	2.72182510
78	protein targeting to mitochondrion (GO:0006626)	2.70999089
79	cytochrome complex assembly (GO:0017004)	2.69421652
80	spinal cord association neuron differentiation (GO:0021527)	2.68987465
81	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.67657285
82	parturition (GO:0007567)	2.67592430
83	actin nucleation (GO:0045010)	2.66474577
84	negative regulation of telomere maintenance (GO:0032205)	2.66473324
85	cell proliferation in forebrain (GO:0021846)	2.65241591
86	cellular biogenic amine catabolic process (GO:0042402)	2.64857919
87	amine catabolic process (GO:0009310)	2.64857919
88	establishment of protein localization to mitochondrion (GO:0072655)	2.60024833
89	regulation of cellular amino acid metabolic process (GO:0006521)	2.59626637
90	pseudouridine synthesis (GO:0001522)	2.59235379
91	regulation of isotype switching to IgG isotypes (GO:0048302)	2.58887639
92	translational initiation (GO:0006413)	2.58601955
93	protein peptidyl-prolyl isomerization (GO:0000413)	2.57755533
94	isoprenoid biosynthetic process (GO:0008299)	2.56826301
95	substrate-independent telencephalic tangential migration (GO:0021826)	2.56804139
96	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.56804139
97	tongue development (GO:0043586)	2.55712765
98	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.55442870
99	ribonucleoprotein complex biogenesis (GO:0022613)	2.52905780
100	estrogen biosynthetic process (GO:0006703)	2.52812788

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.81180025
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.99940124
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.83843878
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.72533401
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.70432771
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.35147246
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.03694296
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.01716660
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.89277022
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.86434434
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.70853762
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.62699658
13	IRF1_19129219_ChIP-ChIP_H3396_Human	2.27896657
14	VDR_22108803_ChIP-Seq_LS180_Human	2.19939726
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.19869007
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.07098772
17	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.02413206
18	MYC_18940864_ChIP-ChIP_HL60_Human	1.81473133
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.80626415
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.72907087
21	ZNF274_21170338_ChIP-Seq_K562_Hela	1.70335368
22	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.69875008
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.65478656
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.62912871
25	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.61178022
26	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.58092855
27	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.57837224
28	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.54462864
29	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.54105210
30	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.52326577
31	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.50905777
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.50242460
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.46740245
34	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.45752015
35	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.44570590
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.44569119
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.42258294
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39684993
39	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.38628694
40	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.37307133
41	TAF2_19829295_ChIP-Seq_ESCs_Human	1.32378983
42	TTF2_22483619_ChIP-Seq_HELA_Human	1.29105304
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.28816216
44	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.25268300
45	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.25205052
46	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.24864868
47	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.22871266
48	XRN2_22483619_ChIP-Seq_HELA_Human	1.21791347
49	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.21157296
50	CIITA_25753668_ChIP-Seq_RAJI_Human	1.18184565
51	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17563825
52	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17187203
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17014917
54	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.16204348
55	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.16111157
56	NANOG_20526341_ChIP-Seq_ESCs_Human	1.14940956
57	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.14669951
58	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.14009813
59	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.13914478
60	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.13818528
61	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.11510457
62	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.10221696
63	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.09822708
64	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.09361566
65	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.06479074
66	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.05653828
67	BCL6_27268052_Chip-Seq_Bcells_Human	1.04692788
68	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.04200791
69	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.02888270
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02701776
71	ERA_21632823_ChIP-Seq_H3396_Human	1.01654402
72	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.01487384
73	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.01413170
74	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.00567672
75	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99596772
76	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99555017
77	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.99552126
78	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.98710044
79	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.98474906
80	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.97991660
81	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.97277592
82	IGF1R_20145208_ChIP-Seq_DFB_Human	0.96519519
83	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.95140015
84	NCOR_22424771_ChIP-Seq_293T_Human	0.94108464
85	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.93263399
86	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.93248045
87	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.91559125
88	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.89557171
89	P53_21459846_ChIP-Seq_SAOS-2_Human	0.89535482
90	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.88154568
91	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.87881403
92	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.86203583
93	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.86186827
94	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.85333876
95	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.83640111
96	CTCF_20526341_ChIP-Seq_ESCs_Human	0.83229926
97	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.83007905
98	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.81752743
99	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.81027087
100	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.80166833

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.79030813
2	MP0003787_abnormal_imprinting	3.45107982
3	MP0005646_abnormal_pituitary_gland	3.38549611
4	MP0009379_abnormal_foot_pigmentation	3.20462468
5	MP0003880_abnormal_central_pattern	2.90478946
6	MP0005645_abnormal_hypothalamus_physiol	2.69062547
7	MP0002163_abnormal_gland_morphology	2.44454653
8	MP0005671_abnormal_response_to	2.35715084
9	MP0004147_increased_porphyrin_level	2.23696723
10	MP0003011_delayed_dark_adaptation	2.06657489
11	MP0002102_abnormal_ear_morphology	2.02963034
12	MP0005423_abnormal_somatic_nervous	2.01745516
13	MP0006276_abnormal_autonomic_nervous	1.88210516
14	MP0002653_abnormal_ependyma_morphology	1.86026961
15	MP0008789_abnormal_olfactory_epithelium	1.85409276
16	MP0001905_abnormal_dopamine_level	1.82726922
17	MP0005379_endocrine/exocrine_gland_phen	1.82400115
18	MP0001348_abnormal_lacrimal_gland	1.75445243
19	MP0009046_muscle_twitch	1.72224650
20	MP0003315_abnormal_perineum_morphology	1.64058220
21	MP0000631_abnormal_neuroendocrine_gland	1.62136803
22	MP0001188_hyperpigmentation	1.57822035
23	MP0001919_abnormal_reproductive_system	1.56751289
24	MP0004142_abnormal_muscle_tone	1.55841884
25	MP0001968_abnormal_touch/_nociception	1.50911585
26	MP0004145_abnormal_muscle_electrophysio	1.45047753
27	MP0008877_abnormal_DNA_methylation	1.44652937
28	MP0005187_abnormal_penis_morphology	1.44269996
29	MP0002160_abnormal_reproductive_system	1.43294177
30	MP0005394_taste/olfaction_phenotype	1.42541470
31	MP0005499_abnormal_olfactory_system	1.42541470
32	MP0005389_reproductive_system_phenotype	1.41949526
33	MP0002138_abnormal_hepatobiliary_system	1.41856442
34	MP0003123_paternal_imprinting	1.41191699
35	MP0001835_abnormal_antigen_presentation	1.40813328
36	MP0002272_abnormal_nervous_system	1.39084104
37	MP0003121_genomic_imprinting	1.38933589
38	MP0009745_abnormal_behavioral_response	1.35191864
39	MP0002938_white_spotting	1.34242891
40	MP0008875_abnormal_xenobiotic_pharmacok	1.33953274
41	MP0000049_abnormal_middle_ear	1.32424805
42	MP0003646_muscle_fatigue	1.29297329
43	MP0004133_heterotaxia	1.28087024
44	MP0005084_abnormal_gallbladder_morpholo	1.27590496
45	MP0000778_abnormal_nervous_system	1.26306942
46	MP0005551_abnormal_eye_electrophysiolog	1.23834157
47	MP0002234_abnormal_pharynx_morphology	1.23614440
48	MP0003122_maternal_imprinting	1.23019906
49	MP0008872_abnormal_physiological_respon	1.20086411
50	MP0002736_abnormal_nociception_after	1.16916014
51	MP0000372_irregular_coat_pigmentation	1.16747409
52	MP0002095_abnormal_skin_pigmentation	1.16256936
53	MP0001293_anophthalmia	1.16240309
54	MP0003635_abnormal_synaptic_transmissio	1.12450876
55	MP0002557_abnormal_social/conspecific_i	1.10965413
56	MP0004742_abnormal_vestibular_system	1.08385063
57	MP0002063_abnormal_learning/memory/cond	1.04860937
58	MP0002184_abnormal_innervation	1.04692155
59	MP0002733_abnormal_thermal_nociception	1.04556765
60	MP0001529_abnormal_vocalization	1.01396800
61	MP0001984_abnormal_olfaction	1.01115791
62	MP0002837_dystrophic_cardiac_calcinosis	0.99916724
63	MP0002572_abnormal_emotion/affect_behav	0.99734338
64	MP0005253_abnormal_eye_physiology	0.97861600
65	MP0002638_abnormal_pupillary_reflex	0.95503703
66	MP0008058_abnormal_DNA_repair	0.95135527
67	MP0002752_abnormal_somatic_nervous	0.94907283
68	MP0003693_abnormal_embryo_hatching	0.94716995
69	MP0002067_abnormal_sensory_capabilities	0.90738284
70	MP0001970_abnormal_pain_threshold	0.90523261
71	MP0001790_abnormal_immune_system	0.88336109
72	MP0005387_immune_system_phenotype	0.88336109
73	MP0001873_stomach_inflammation	0.88067134
74	MP0005195_abnormal_posterior_eye	0.87993748
75	MP0004859_abnormal_synaptic_plasticity	0.87430515
76	MP0006072_abnormal_retinal_apoptosis	0.86345793
77	MP0004885_abnormal_endolymph	0.86278339
78	MP0003567_abnormal_fetal_cardiomyocyte	0.86158604
79	MP0001800_abnormal_humoral_immune	0.86143997
80	MP0000955_abnormal_spinal_cord	0.86073542
81	MP0000026_abnormal_inner_ear	0.86034511
82	MP0002822_catalepsy	0.85022920
83	MP0003136_yellow_coat_color	0.83885222
84	MP0003186_abnormal_redox_activity	0.83581766
85	MP0000685_abnormal_immune_system	0.83260087
86	MP0009333_abnormal_splenocyte_physiolog	0.83045673
87	MP0003878_abnormal_ear_physiology	0.82734098
88	MP0005377_hearing/vestibular/ear_phenot	0.82734098
89	MP0000613_abnormal_salivary_gland	0.81366106
90	MP0002210_abnormal_sex_determination	0.81170765
91	MP0002064_seizures	0.79055563
92	MP0001986_abnormal_taste_sensitivity	0.76646972
93	MP0001485_abnormal_pinna_reflex	0.76111469
94	MP0006036_abnormal_mitochondrial_physio	0.74984668
95	MP0003718_maternal_effect	0.74864625
96	MP0002876_abnormal_thyroid_physiology	0.74560261
97	MP0002882_abnormal_neuron_morphology	0.73097203
98	MP0001119_abnormal_female_reproductive	0.70451713
99	MP0003938_abnormal_ear_development	0.69332430
100	MP0002735_abnormal_chemical_nociception	0.69327245

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.28360041
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.95624780
3	Mitochondrial inheritance (HP:0001427)	4.72611791
4	Acute encephalopathy (HP:0006846)	4.58575107
5	Progressive macrocephaly (HP:0004481)	4.15819590
6	Increased CSF lactate (HP:0002490)	4.02961371
7	Hepatocellular necrosis (HP:0001404)	3.95003292
8	Lipid accumulation in hepatocytes (HP:0006561)	3.46021762
9	Increased hepatocellular lipid droplets (HP:0006565)	3.45495114
10	Hepatic necrosis (HP:0002605)	3.45118223
11	Congenital stationary night blindness (HP:0007642)	3.21977392
12	Cerebral edema (HP:0002181)	3.17547252
13	Renal Fanconi syndrome (HP:0001994)	3.17336098
14	3-Methylglutaconic aciduria (HP:0003535)	3.16338178
15	Pancreatic fibrosis (HP:0100732)	3.05844960
16	Abnormality of cells of the erythroid lineage (HP:0012130)	2.95023161
17	Increased intramyocellular lipid droplets (HP:0012240)	2.94671189
18	Pancreatic cysts (HP:0001737)	2.86631906
19	Increased serum lactate (HP:0002151)	2.85585829
20	Optic disc pallor (HP:0000543)	2.83474922
21	Elevated erythrocyte sedimentation rate (HP:0003565)	2.77252790
22	Abnormality of midbrain morphology (HP:0002418)	2.75962324
23	Molar tooth sign on MRI (HP:0002419)	2.75962324
24	Abnormal ciliary motility (HP:0012262)	2.69680653
25	Lactic acidosis (HP:0003128)	2.68180186
26	Rib fusion (HP:0000902)	2.61242687
27	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.61221301
28	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.61221301
29	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.60818169
30	Leukodystrophy (HP:0002415)	2.60642989
31	Increased muscle lipid content (HP:0009058)	2.59466156
32	Abnormal number of erythroid precursors (HP:0012131)	2.53127679
33	True hermaphroditism (HP:0010459)	2.50759260
34	Myokymia (HP:0002411)	2.48630030
35	Medial flaring of the eyebrow (HP:0010747)	2.46031612
36	Abnormality of renal resorption (HP:0011038)	2.43613317
37	Sclerocornea (HP:0000647)	2.41456206
38	Reticulocytopenia (HP:0001896)	2.38522046
39	Nephronophthisis (HP:0000090)	2.36412138
40	IgG deficiency (HP:0004315)	2.28914873
41	Exercise intolerance (HP:0003546)	2.27474086
42	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.25831231
43	Abnormal respiratory motile cilium physiology (HP:0012261)	2.25009148
44	Abnormal respiratory epithelium morphology (HP:0012253)	2.21601297
45	Abnormal respiratory motile cilium morphology (HP:0005938)	2.21601297
46	Abolished electroretinogram (ERG) (HP:0000550)	2.18697935
47	Exertional dyspnea (HP:0002875)	2.14928179
48	Aplastic anemia (HP:0001915)	2.11297037
49	Microretrognathia (HP:0000308)	2.10448138
50	Respiratory failure (HP:0002878)	2.10218425
51	Lethargy (HP:0001254)	2.07779346
52	Abnormality of alanine metabolism (HP:0010916)	2.07460173
53	Hyperalaninemia (HP:0003348)	2.07460173
54	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.07460173
55	Chronic obstructive pulmonary disease (HP:0006510)	2.06115222
56	Obstructive lung disease (HP:0006536)	2.06115222
57	Progressive cerebellar ataxia (HP:0002073)	2.05035895
58	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.04314053
59	Abnormal rod and cone electroretinograms (HP:0008323)	2.03367120
60	X-linked dominant inheritance (HP:0001423)	2.02423502
61	Agitation (HP:0000713)	2.01906500
62	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.00525946
63	Hyperglycinemia (HP:0002154)	2.00481527
64	Macrocytic anemia (HP:0001972)	1.99477475
65	Abnormality of the prostate (HP:0008775)	1.98023358
66	Severe visual impairment (HP:0001141)	1.97676368
67	Absent thumb (HP:0009777)	1.95398313
68	Increased IgM level (HP:0003496)	1.95272604
69	Patent foramen ovale (HP:0001655)	1.94144490
70	Anophthalmia (HP:0000528)	1.89192292
71	Hyperthyroidism (HP:0000836)	1.88703453
72	Abnormality of the renal medulla (HP:0100957)	1.88135635
73	Type I transferrin isoform profile (HP:0003642)	1.87837168
74	Pendular nystagmus (HP:0012043)	1.87182734
75	Glycosuria (HP:0003076)	1.86629342
76	Abnormality of urine glucose concentration (HP:0011016)	1.86629342
77	Nephrogenic diabetes insipidus (HP:0009806)	1.85175339
78	Hyperphosphaturia (HP:0003109)	1.84589132
79	Colon cancer (HP:0003003)	1.84581494
80	Gait imbalance (HP:0002141)	1.83739000
81	Lissencephaly (HP:0001339)	1.82414771
82	Septo-optic dysplasia (HP:0100842)	1.82109474
83	Abnormal hair whorl (HP:0010721)	1.79657866
84	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.79269993
85	Absent/shortened dynein arms (HP:0200106)	1.79269993
86	Agammaglobulinemia (HP:0004432)	1.79238059
87	Cystic liver disease (HP:0006706)	1.74531986
88	Congenital primary aphakia (HP:0007707)	1.72642652
89	Bile duct proliferation (HP:0001408)	1.70316654
90	Abnormal biliary tract physiology (HP:0012439)	1.70316654
91	Progressive microcephaly (HP:0000253)	1.69814696
92	Abnormal drinking behavior (HP:0030082)	1.66584978
93	Polydipsia (HP:0001959)	1.66584978
94	Type II lissencephaly (HP:0007260)	1.63660874
95	Hypoplasia of the radius (HP:0002984)	1.63365898
96	Neutropenia (HP:0001875)	1.62502456
97	Severe combined immunodeficiency (HP:0004430)	1.59655250
98	Anosmia (HP:0000458)	1.57385049
99	Large eyes (HP:0001090)	1.57244382
100	Male pseudohermaphroditism (HP:0000037)	1.56694880

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR1B	3.38712944
2	VRK2	3.20449606
3	BCKDK	3.16827125
4	TXK	2.98470917
5	VRK1	2.87151135
6	WNK4	2.83459777
7	ZAK	2.82146306
8	DYRK2	2.59263536
9	MAP2K7	2.55445538
10	KDR	2.30001847
11	TLK1	2.23585253
12	MAP3K4	2.13431492
13	CDK19	2.12957689
14	MAP4K2	1.93236838
15	TYRO3	1.85156045
16	MUSK	1.81379812
17	PIM2	1.70956241
18	ADRBK2	1.59848051
19	GRK1	1.57287487
20	NUAK1	1.55749769
21	AURKA	1.48326392
22	WNK3	1.48313036
23	STK16	1.44377152
24	NTRK2	1.43990820
25	DAPK3	1.42945056
26	TESK2	1.42836239
27	STK39	1.37529760
28	CASK	1.34665747
29	LIMK1	1.32579702
30	MAP3K11	1.29867104
31	RPS6KA5	1.29785197
32	BUB1	1.23521139
33	PRKCQ	1.19564212
34	MINK1	1.08799881
35	OXSR1	1.08504441
36	MAP4K1	1.08352801
37	PRKCG	1.08195872
38	ITK	1.08175330
39	TNK2	1.06552285
40	PINK1	1.05303453
41	TAOK3	1.01168341
42	TAF1	0.93065378
43	INSRR	0.91066696
44	PRKCH	0.90753362
45	NME1	0.88766640
46	DYRK1B	0.86873984
47	FES	0.86609893
48	DYRK3	0.85244986
49	BTK	0.82608063
50	AURKB	0.82396223
51	CSNK1G2	0.74493969
52	EPHA4	0.73185064
53	CSNK1G3	0.73052541
54	CDC7	0.71349842
55	MAP3K12	0.70870084
56	SYK	0.70646680
57	TIE1	0.69821402
58	LYN	0.66069900
59	TEC	0.65983701
60	MST4	0.65016923
61	MAPK13	0.64520152
62	CAMK1	0.64361964
63	CSNK1A1L	0.62765939
64	CSNK2A2	0.61138873
65	PLK1	0.58018988
66	ATR	0.56294003
67	MARK1	0.56095690
68	ARAF	0.55258460
69	PRKACA	0.53226285
70	PKN1	0.52878163
71	RPS6KA4	0.51851928
72	NEK1	0.44182771
73	PRKCD	0.44050170
74	MATK	0.43933904
75	CSNK1G1	0.43667553
76	BRAF	0.43665159
77	CSNK1A1	0.43210414
78	CSNK2A1	0.43050535
79	PAK1	0.42862720
80	PAK3	0.40692253
81	CDK5	0.39498022
82	CSNK1E	0.38412338
83	CAMK2A	0.38283386
84	WNK1	0.37652207
85	PTK6	0.37588359
86	LCK	0.37343281
87	CDK11A	0.36390789
88	TESK1	0.36228257
89	TNIK	0.35798524
90	CDK14	0.33391335
91	PRKCA	0.33236479
92	IKBKB	0.32536432
93	RPS6KA6	0.32068558
94	SGK494	0.31715297
95	SGK223	0.31715297
96	CSF1R	0.31582808
97	STK11	0.31371640
98	ROCK1	0.30260969
99	IKBKE	0.30149134
100	CDK15	0.29167461

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.34994829
2	Ribosome_Homo sapiens_hsa03010	3.84469104
3	Parkinsons disease_Homo sapiens_hsa05012	3.72375585
4	Proteasome_Homo sapiens_hsa03050	3.36583946
5	Systemic lupus erythematosus_Homo sapiens_hsa05322	3.08321557
6	Protein export_Homo sapiens_hsa03060	2.94208405
7	Alzheimers disease_Homo sapiens_hsa05010	2.57179446
8	Huntingtons disease_Homo sapiens_hsa05016	2.55440114
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.45466271
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.45109097
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.36314650
12	Asthma_Homo sapiens_hsa05310	2.29841442
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.20984098
14	Allograft rejection_Homo sapiens_hsa05330	2.18277834
15	RNA polymerase_Homo sapiens_hsa03020	2.13001121
16	Alcoholism_Homo sapiens_hsa05034	2.07120666
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.04306025
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.03288702
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.03263581
20	Graft-versus-host disease_Homo sapiens_hsa05332	2.00045654
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.84045991
22	Type I diabetes mellitus_Homo sapiens_hsa04940	1.65283807
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.47799156
24	Steroid biosynthesis_Homo sapiens_hsa00100	1.46895604
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.43480278
26	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.40703160
27	Homologous recombination_Homo sapiens_hsa03440	1.36428205
28	Sulfur relay system_Homo sapiens_hsa04122	1.29502707
29	Phototransduction_Homo sapiens_hsa04744	1.20942167
30	Basal transcription factors_Homo sapiens_hsa03022	1.20885346
31	Antigen processing and presentation_Homo sapiens_hsa04612	1.10213650
32	Spliceosome_Homo sapiens_hsa03040	0.98775772
33	Pyrimidine metabolism_Homo sapiens_hsa00240	0.98485404
34	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.98353978
35	RNA degradation_Homo sapiens_hsa03018	0.97314721
36	Peroxisome_Homo sapiens_hsa04146	0.96942533
37	Butanoate metabolism_Homo sapiens_hsa00650	0.94880754
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.92102272
39	Linoleic acid metabolism_Homo sapiens_hsa00591	0.91196704
40	Rheumatoid arthritis_Homo sapiens_hsa05323	0.90662657
41	Nicotine addiction_Homo sapiens_hsa05033	0.89376026
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.89331556
43	DNA replication_Homo sapiens_hsa03030	0.88430966
44	Propanoate metabolism_Homo sapiens_hsa00640	0.82323628
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.82163086
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.81112172
47	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.80279264
48	Viral myocarditis_Homo sapiens_hsa05416	0.78024101
49	Mismatch repair_Homo sapiens_hsa03430	0.73657718
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.70232985
51	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.69707910
52	Nitrogen metabolism_Homo sapiens_hsa00910	0.67779192
53	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.66818933
54	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.65804061
55	Nucleotide excision repair_Homo sapiens_hsa03420	0.65751398
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65592522
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62739952
58	Fanconi anemia pathway_Homo sapiens_hsa03460	0.62260162
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61499381
60	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.61262839
61	Retinol metabolism_Homo sapiens_hsa00830	0.57466921
62	Metabolic pathways_Homo sapiens_hsa01100	0.56683676
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.54820158
64	Olfactory transduction_Homo sapiens_hsa04740	0.53936738
65	RNA transport_Homo sapiens_hsa03013	0.51119938
66	Base excision repair_Homo sapiens_hsa03410	0.50578549
67	Phenylalanine metabolism_Homo sapiens_hsa00360	0.49837215
68	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49170639
69	Tyrosine metabolism_Homo sapiens_hsa00350	0.47248933
70	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.47039280
71	Purine metabolism_Homo sapiens_hsa00230	0.46227423
72	Morphine addiction_Homo sapiens_hsa05032	0.45647901
73	One carbon pool by folate_Homo sapiens_hsa00670	0.45379524
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44615164
75	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.43823476
76	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.42922055
77	GABAergic synapse_Homo sapiens_hsa04727	0.41266111
78	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.39748616
79	Selenocompound metabolism_Homo sapiens_hsa00450	0.39136902
80	Fatty acid degradation_Homo sapiens_hsa00071	0.38600542
81	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.38069113
82	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.36638581
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.35053618
84	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.32839818
85	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.32622797
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.30153970
87	Sulfur metabolism_Homo sapiens_hsa00920	0.28102381
88	Pyruvate metabolism_Homo sapiens_hsa00620	0.25562714
89	Chemical carcinogenesis_Homo sapiens_hsa05204	0.25470793
90	Ether lipid metabolism_Homo sapiens_hsa00565	0.25282718
91	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.25029620
92	Caffeine metabolism_Homo sapiens_hsa00232	0.23163749
93	Basal cell carcinoma_Homo sapiens_hsa05217	0.22639020
94	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.20861464
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.20673723
96	Dopaminergic synapse_Homo sapiens_hsa04728	0.20302223
97	Serotonergic synapse_Homo sapiens_hsa04726	0.19814841
98	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.18135529
99	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.17797204
100	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.16132245

HSPE1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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