HSPE1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.97886501
2maturation of 5.8S rRNA (GO:0000460)4.72181606
3ribosome assembly (GO:0042255)4.39071587
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.39024180
5ATP synthesis coupled proton transport (GO:0015986)4.39024180
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.37659826
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.27991551
8chaperone-mediated protein transport (GO:0072321)4.25853517
9negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.19603724
10rRNA modification (GO:0000154)4.16257037
11DNA double-strand break processing (GO:0000729)4.04561359
12pseudouridine synthesis (GO:0001522)4.00136768
13cullin deneddylation (GO:0010388)3.93518512
14regulation of cellular amino acid metabolic process (GO:0006521)3.92969302
15protein neddylation (GO:0045116)3.91379662
16positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.89956034
17negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.88615575
18negative regulation of ligase activity (GO:0051352)3.88615575
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.88433647
20exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.86552737
21DNA deamination (GO:0045006)3.86270227
22ribosomal large subunit biogenesis (GO:0042273)3.84583175
23protein deneddylation (GO:0000338)3.81726103
24nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.80700049
25DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.75082166
26rRNA methylation (GO:0031167)3.74864780
27signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.72253436
28signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.72253436
29signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.72253436
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.71359570
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.71359570
32somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.70031444
33somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.70031444
34isotype switching (GO:0045190)3.70031444
35intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.68356565
36signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.68356565
37rRNA processing (GO:0006364)3.67313988
38IMP biosynthetic process (GO:0006188)3.62590123
39signal transduction involved in DNA integrity checkpoint (GO:0072401)3.57581300
40signal transduction involved in DNA damage checkpoint (GO:0072422)3.57581300
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.57030155
42folic acid-containing compound biosynthetic process (GO:0009396)3.55484129
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.55217536
44termination of RNA polymerase III transcription (GO:0006386)3.55217536
45rRNA metabolic process (GO:0016072)3.54877869
46nucleobase biosynthetic process (GO:0046112)3.51136526
47signal transduction involved in cell cycle checkpoint (GO:0072395)3.50414780
48chromatin remodeling at centromere (GO:0031055)3.48255458
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.46945035
50DNA damage response, detection of DNA damage (GO:0042769)3.43436690
51maturation of SSU-rRNA (GO:0030490)3.41664104
52amino acid activation (GO:0043038)3.40298378
53tRNA aminoacylation (GO:0043039)3.40298378
54DNA catabolic process, exonucleolytic (GO:0000738)3.39403178
55CENP-A containing nucleosome assembly (GO:0034080)3.36982538
56tRNA aminoacylation for protein translation (GO:0006418)3.33984089
57positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.33735215
58DNA replication checkpoint (GO:0000076)3.32407948
59purine nucleobase biosynthetic process (GO:0009113)3.30321755
60tRNA metabolic process (GO:0006399)3.27964594
61ribosome biogenesis (GO:0042254)3.27016756
62mitochondrial respiratory chain complex assembly (GO:0033108)3.26841476
63respiratory chain complex IV assembly (GO:0008535)3.26832682
64GTP biosynthetic process (GO:0006183)3.24680680
65positive regulation of ligase activity (GO:0051351)3.24096489
66IMP metabolic process (GO:0046040)3.23978775
67protein targeting to mitochondrion (GO:0006626)3.23928912
68protein complex biogenesis (GO:0070271)3.23502517
69tRNA processing (GO:0008033)3.20265161
70peptidyl-histidine modification (GO:0018202)3.19434292
71termination of RNA polymerase I transcription (GO:0006363)3.17375999
72RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.16917766
73transcription elongation from RNA polymerase I promoter (GO:0006362)3.15619333
74regulation of mitotic spindle checkpoint (GO:1903504)3.15454742
75regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.15454742
76water-soluble vitamin biosynthetic process (GO:0042364)3.14490139
77ribonucleoprotein complex biogenesis (GO:0022613)3.14087237
78translation (GO:0006412)3.13545295
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.13076776
80histone mRNA metabolic process (GO:0008334)3.11506270
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.10081500
82mitochondrial respiratory chain complex I assembly (GO:0032981)3.10081500
83NADH dehydrogenase complex assembly (GO:0010257)3.10081500
84cellular component biogenesis (GO:0044085)3.06700685
85transcription from mitochondrial promoter (GO:0006390)3.06448819
86ncRNA metabolic process (GO:0034660)3.05728703
87CTP biosynthetic process (GO:0006241)3.05434826
88CTP metabolic process (GO:0046036)3.05434826
89regulation of immunoglobulin secretion (GO:0051023)3.05427270
90respiratory electron transport chain (GO:0022904)3.04349734
91protein localization to mitochondrion (GO:0070585)3.02560216
92ncRNA processing (GO:0034470)3.02539561
93ribosomal small subunit assembly (GO:0000028)3.02402358
94electron transport chain (GO:0022900)3.01867376
95regulation of ubiquitin-protein transferase activity (GO:0051438)3.01618667
96pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.00972622
97UTP biosynthetic process (GO:0006228)3.00062613
98pteridine-containing compound biosynthetic process (GO:0042559)2.99952567
99establishment of integrated proviral latency (GO:0075713)2.98550741
100positive regulation of cell cycle arrest (GO:0071158)2.98472815

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.51741513
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.89255555
3E2F7_22180533_ChIP-Seq_HELA_Human4.55400589
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.24641794
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.70607977
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.42003468
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.18066125
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.15321306
9ELK1_19687146_ChIP-ChIP_HELA_Human3.02807282
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.91416084
11VDR_23849224_ChIP-Seq_CD4+_Human2.83383705
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82301836
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.80241669
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.75882606
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64868461
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.52807551
17FOXP3_21729870_ChIP-Seq_TREG_Human2.51248875
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.43556841
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41368017
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34436499
21DCP1A_22483619_ChIP-Seq_HELA_Human2.30522877
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25888479
23FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.18534807
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12839814
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12791303
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12296993
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02801574
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01643382
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.99103761
30TTF2_22483619_ChIP-Seq_HELA_Human1.97768045
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.96169396
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89326509
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.87766678
34VDR_22108803_ChIP-Seq_LS180_Human1.86920713
35GABP_19822575_ChIP-Seq_HepG2_Human1.82789645
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.81217392
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78995824
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77798802
39MYC_18940864_ChIP-ChIP_HL60_Human1.67800607
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63434725
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63393204
42ZNF274_21170338_ChIP-Seq_K562_Hela1.62766594
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62574892
44EWS_26573619_Chip-Seq_HEK293_Human1.58670583
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56643077
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53670910
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.50807363
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49444302
49XRN2_22483619_ChIP-Seq_HELA_Human1.48400468
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39704418
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34925148
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33221327
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.30466881
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27889010
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27184449
56ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27161031
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.23662993
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23497131
59AR_21909140_ChIP-Seq_LNCAP_Human1.22858995
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22266190
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20320647
62FUS_26573619_Chip-Seq_HEK293_Human1.18409547
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16515137
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14865416
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.11958828
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.10530847
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.07515047
68TP53_22573176_ChIP-Seq_HFKS_Human1.07259086
69KDM5A_27292631_Chip-Seq_BREAST_Human1.05529409
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02650826
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00126129
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98913763
73FOXM1_23109430_ChIP-Seq_U2OS_Human0.98715343
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98255511
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.97209302
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96805415
77EZH2_27294783_Chip-Seq_NPCs_Mouse0.96640907
78ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93279223
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90531546
80ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88561587
81NANOG_16153702_ChIP-ChIP_HESCs_Human0.87976071
82FOXA1_25329375_ChIP-Seq_VCAP_Human0.84287793
83FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84287793
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83617023
85IRF1_19129219_ChIP-ChIP_H3396_Human0.83019901
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80513262
87POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80448163
88P300_19829295_ChIP-Seq_ESCs_Human0.79448346
89ELF5_23300383_ChIP-Seq_T47D_Human0.79329752
90POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78365711
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76929940
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76857686
93CRX_20693478_ChIP-Seq_RETINA_Mouse0.76791814
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75555488
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.75249735
96NANOG_18555785_ChIP-Seq_MESCs_Mouse0.73938698
97P300_18555785_Chip-Seq_ESCs_Mouse0.73100458
98NANOG_19829295_ChIP-Seq_ESCs_Human0.72274984
99SOX2_19829295_ChIP-Seq_ESCs_Human0.72274984
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.71879805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.76486831
2MP0004957_abnormal_blastocyst_morpholog3.72405477
3MP0010094_abnormal_chromosome_stability3.60291993
4MP0008058_abnormal_DNA_repair3.46465552
5MP0001835_abnormal_antigen_presentation3.29580606
6MP0008877_abnormal_DNA_methylation3.17957409
7MP0003806_abnormal_nucleotide_metabolis2.90709942
8MP0008057_abnormal_DNA_replication2.88763906
9MP0003786_premature_aging2.73545906
10MP0001873_stomach_inflammation2.46135046
11MP0006072_abnormal_retinal_apoptosis2.40842049
12MP0005671_abnormal_response_to2.37652559
13MP0003111_abnormal_nucleus_morphology2.35806071
14MP0003186_abnormal_redox_activity2.23980202
15MP0003077_abnormal_cell_cycle2.19309528
16MP0009697_abnormal_copulation2.14097411
17MP0003718_maternal_effect2.01382622
18MP0008932_abnormal_embryonic_tissue1.86768239
19MP0002102_abnormal_ear_morphology1.85539789
20MP0008872_abnormal_physiological_respon1.85530883
21MP0006036_abnormal_mitochondrial_physio1.84109821
22MP0001529_abnormal_vocalization1.83357785
23MP0008007_abnormal_cellular_replicative1.83241428
24MP0004147_increased_porphyrin_level1.76930011
25MP0002006_tumorigenesis1.71370172
26MP0000685_abnormal_immune_system1.66038458
27MP0001790_abnormal_immune_system1.65984034
28MP0005387_immune_system_phenotype1.65984034
29MP0009785_altered_susceptibility_to1.64257505
30MP0005084_abnormal_gallbladder_morpholo1.63423614
31MP0002163_abnormal_gland_morphology1.62754301
32MP0009333_abnormal_splenocyte_physiolog1.61549385
33MP0003195_calcinosis1.57324856
34MP0008875_abnormal_xenobiotic_pharmacok1.53985625
35MP0001661_extended_life_span1.45353714
36MP0002837_dystrophic_cardiac_calcinosis1.44943627
37MP0006292_abnormal_olfactory_placode1.39943596
38MP0003890_abnormal_embryonic-extraembry1.38972928
39MP0001348_abnormal_lacrimal_gland1.32816182
40MP0000372_irregular_coat_pigmentation1.25247701
41MP0005645_abnormal_hypothalamus_physiol1.25208277
42MP0002148_abnormal_hypersensitivity_rea1.24083447
43MP0003567_abnormal_fetal_cardiomyocyte1.22200969
44MP0004782_abnormal_surfactant_physiolog1.19540559
45MP0000516_abnormal_urinary_system1.16068142
46MP0005367_renal/urinary_system_phenotyp1.16068142
47MP0001730_embryonic_growth_arrest1.14414234
48MP0001800_abnormal_humoral_immune1.11397992
49MP0002166_altered_tumor_susceptibility1.10303037
50MP0006035_abnormal_mitochondrial_morpho1.09497511
51MP0000490_abnormal_crypts_of1.07897514
52MP0001293_anophthalmia1.07494369
53MP0003941_abnormal_skin_development1.05165341
54MP0005075_abnormal_melanosome_morpholog1.03880257
55MP0006054_spinal_hemorrhage1.02637066
56MP0001853_heart_inflammation1.01746189
57MP0001881_abnormal_mammary_gland1.01679167
58MP0005379_endocrine/exocrine_gland_phen1.01477981
59MP0001188_hyperpigmentation1.00936241
60MP0004215_abnormal_myocardial_fiber0.99036194
61MP0005332_abnormal_amino_acid0.98148464
62MP0009379_abnormal_foot_pigmentation0.96498252
63MP0003646_muscle_fatigue0.94964423
64MP0002210_abnormal_sex_determination0.94739449
65MP0010307_abnormal_tumor_latency0.91826971
66MP0002751_abnormal_autonomic_nervous0.91507774
67MP0008873_increased_physiological_sensi0.89343803
68MP0000427_abnormal_hair_cycle0.88258151
69MP0002019_abnormal_tumor_incidence0.87139684
70MP0005408_hypopigmentation0.86580436
71MP0005636_abnormal_mineral_homeostasis0.86220637
72MP0003936_abnormal_reproductive_system0.85005131
73MP0002138_abnormal_hepatobiliary_system0.82766535
74MP0004145_abnormal_muscle_electrophysio0.82146086
75MP0005389_reproductive_system_phenotype0.81975229
76MP0001984_abnormal_olfaction0.81930610
77MP0001929_abnormal_gametogenesis0.80942722
78MP0005551_abnormal_eye_electrophysiolog0.80934873
79MP0001727_abnormal_embryo_implantation0.80559892
80MP0005000_abnormal_immune_tolerance0.79723384
81MP0001501_abnormal_sleep_pattern0.79039791
82MP0003937_abnormal_limbs/digits/tail_de0.78122772
83MP0001919_abnormal_reproductive_system0.77451535
84MP0000313_abnormal_cell_death0.77281563
85MP0000350_abnormal_cell_proliferation0.76164942
86MP0005410_abnormal_fertilization0.75183594
87MP0008995_early_reproductive_senescence0.75028431
88MP0002396_abnormal_hematopoietic_system0.74585603
89MP0000653_abnormal_sex_gland0.74101504
90MP0005253_abnormal_eye_physiology0.73995092
91MP0002938_white_spotting0.73523689
92MP0001145_abnormal_male_reproductive0.72969226
93MP0009764_decreased_sensitivity_to0.72566579
94MP0001697_abnormal_embryo_size0.72536863
95MP0001119_abnormal_female_reproductive0.71768555
96MP0000689_abnormal_spleen_morphology0.71531088
97MP0002736_abnormal_nociception_after0.71447487
98MP0000627_abnormal_mammary_gland0.70915223
99MP0001286_abnormal_eye_development0.70597421
100MP0002234_abnormal_pharynx_morphology0.70349610

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.12557323
2Increased hepatocellular lipid droplets (HP:0006565)4.66438780
3Acute encephalopathy (HP:0006846)4.51744799
4Abnormal mitochondria in muscle tissue (HP:0008316)4.45904421
5Increased CSF lactate (HP:0002490)4.34446676
6Mitochondrial inheritance (HP:0001427)4.29687006
7Progressive macrocephaly (HP:0004481)4.25701729
8Lipid accumulation in hepatocytes (HP:0006561)4.24799239
9Congenital, generalized hypertrichosis (HP:0004540)3.72550332
10Stomatitis (HP:0010280)3.70978194
11Hepatocellular necrosis (HP:0001404)3.51440250
123-Methylglutaconic aciduria (HP:0003535)3.48895813
13Cerebral edema (HP:0002181)3.45207533
14Renal Fanconi syndrome (HP:0001994)3.35706056
15Increased serum lactate (HP:0002151)3.29844586
16Exertional dyspnea (HP:0002875)3.27042869
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.12176953
18Hepatic necrosis (HP:0002605)3.11005396
19Increased intramyocellular lipid droplets (HP:0012240)2.94835152
20Abnormality of alanine metabolism (HP:0010916)2.89277151
21Hyperalaninemia (HP:0003348)2.89277151
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.89277151
23Abnormality of the pons (HP:0007361)2.88850319
24Abnormality of the anterior horn cell (HP:0006802)2.81053768
25Degeneration of anterior horn cells (HP:0002398)2.81053768
26Leukodystrophy (HP:0002415)2.78587082
27Colon cancer (HP:0003003)2.77583316
28Lactic acidosis (HP:0003128)2.75556679
29IgG deficiency (HP:0004315)2.72739144
30Hypoplasia of the pons (HP:0012110)2.68259180
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.64506906
32Methylmalonic acidemia (HP:0002912)2.63097820
33Respiratory difficulties (HP:0002880)2.62578402
34Optic disc pallor (HP:0000543)2.54636279
35Exercise intolerance (HP:0003546)2.51561023
36Meckel diverticulum (HP:0002245)2.49228784
37Abnormality of the labia minora (HP:0012880)2.46319512
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.43889295
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.43889295
40Increased serum pyruvate (HP:0003542)2.39123019
41Abnormality of the ileum (HP:0001549)2.36797421
42Respiratory failure (HP:0002878)2.36547938
43Aplastic anemia (HP:0001915)2.34167040
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.33848785
45Increased muscle lipid content (HP:0009058)2.31498883
46Abnormality of the preputium (HP:0100587)2.29924098
47Multiple enchondromatosis (HP:0005701)2.29629035
48Microvesicular hepatic steatosis (HP:0001414)2.25805772
49Abnormality of chromosome stability (HP:0003220)2.21252540
50Lethargy (HP:0001254)2.16932743
51Hypoproteinemia (HP:0003075)2.15170613
52Hypothermia (HP:0002045)2.13388436
53Abnormality of methionine metabolism (HP:0010901)2.11906838
54Absent thumb (HP:0009777)2.11006921
55Abnormality of glycolysis (HP:0004366)2.09335078
56Abnormality of midbrain morphology (HP:0002418)2.08240192
57Molar tooth sign on MRI (HP:0002419)2.08240192
58Pancreatic cysts (HP:0001737)2.07156099
59Abnormality of serum amino acid levels (HP:0003112)2.06939541
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05536336
61Chromsome breakage (HP:0040012)2.04067370
62Pancytopenia (HP:0001876)2.02720748
63Bile duct proliferation (HP:0001408)1.98999361
64Abnormal biliary tract physiology (HP:0012439)1.98999361
65Cleft eyelid (HP:0000625)1.96634107
66Testicular atrophy (HP:0000029)1.96043204
67Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92317091
68Abnormality of renal resorption (HP:0011038)1.91588645
69Methylmalonic aciduria (HP:0012120)1.89801481
70Megaloblastic anemia (HP:0001889)1.88656485
71Palpitations (HP:0001962)1.88309929
72Abolished electroretinogram (ERG) (HP:0000550)1.88144104
73Horseshoe kidney (HP:0000085)1.84399731
74Cerebral hypomyelination (HP:0006808)1.83213487
75Reticulocytopenia (HP:0001896)1.82805867
76Increased IgM level (HP:0003496)1.81941792
77Type I transferrin isoform profile (HP:0003642)1.81897443
78Macrocytic anemia (HP:0001972)1.79107051
79Small intestinal stenosis (HP:0012848)1.79031449
80Duodenal stenosis (HP:0100867)1.79031449
81Aplasia/hypoplasia of the uterus (HP:0008684)1.78995539
82Abnormality of the vitamin B12 metabolism (HP:0004341)1.76893775
83Progressive microcephaly (HP:0000253)1.76483573
84Abnormality of vitamin B metabolism (HP:0004340)1.76382566
85Congenital stationary night blindness (HP:0007642)1.74739892
86Amniotic constriction ring (HP:0009775)1.74682046
87Abnormality of placental membranes (HP:0011409)1.74682046
88Birth length less than 3rd percentile (HP:0003561)1.74457411
89Sensory axonal neuropathy (HP:0003390)1.74032622
90Abnormality of T cell physiology (HP:0011840)1.72989438
91Abnormality of urine glucose concentration (HP:0011016)1.71497408
92Glycosuria (HP:0003076)1.71497408
93Hyperphosphaturia (HP:0003109)1.68716601
94Oral leukoplakia (HP:0002745)1.68349686
95CNS demyelination (HP:0007305)1.67837492
96Aplasia/hypoplasia of the humerus (HP:0006507)1.66927524
97Abnormality of the duodenum (HP:0002246)1.66581477
98Clubbing of toes (HP:0100760)1.66281574
99Sparse eyelashes (HP:0000653)1.66231624
100B lymphocytopenia (HP:0010976)1.65302134

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK65.75646413
2EIF2AK33.76618423
3MST43.73869717
4EIF2AK13.32061044
5SRPK13.11111124
6NEK13.09714214
7BUB12.74118987
8VRK22.60804912
9PBK2.44304815
10NUAK12.41683977
11PLK32.19150661
12MAP3K122.11440474
13MKNK22.00540041
14ZAK2.00074164
15TXK1.97060012
16TTK1.91991331
17TRIM281.90052170
18MKNK11.72392654
19PLK41.71407232
20NME11.64229868
21CDC71.60381255
22MAP4K21.59369184
23NME21.58686677
24TAF11.57939861
25WNK41.48301796
26PASK1.34583146
27VRK11.34183414
28WNK31.32246172
29SIK31.30109131
30EIF2AK21.29380665
31GRK11.24159685
32TLK11.18700543
33PLK11.13965893
34BMPR1B1.07904462
35ADRBK21.07240053
36ALK1.03417700
37BMPR21.02105363
38ACVR1B0.99389953
39WEE10.96665321
40STK390.95821669
41ATR0.94096104
42TNIK0.92309139
43OXSR10.92194535
44TEC0.89860234
45CDK190.86817749
46BCKDK0.86041807
47STK160.85971205
48ILK0.81470787
49PAK40.81188220
50CSNK1G30.79972529
51CSNK1G10.77354143
52PDK20.77281043
53FRK0.76203434
54MAP2K60.76047294
55ERBB30.74276521
56DAPK10.71523576
57AURKB0.70507689
58CSNK1A1L0.69914588
59CSNK1G20.69859205
60FLT30.65804124
61BCR0.63810068
62SCYL20.63052561
63PHKG10.62224302
64PHKG20.62224302
65MYLK0.61385949
66TIE10.59577338
67PLK20.59042719
68ERBB40.57237580
69BRSK20.56093682
70CSNK2A20.52737939
71ATM0.50874241
72CSNK2A10.50489824
73TGFBR10.49839728
74CHEK20.49801162
75CDK80.48399450
76CSNK1E0.46079056
77FGFR10.45528346
78MAPKAPK50.44283785
79WNK10.43276579
80CHEK10.41836611
81STK30.40738207
82TAOK30.37431666
83STK40.36760229
84CDK70.36669026
85IKBKB0.33559996
86STK100.30140990
87TESK10.28820614
88DYRK20.28102682
89BRSK10.26712602
90INSRR0.24754162
91MAP3K80.24702585
92PIK3CG0.23363441
93MAP3K140.23148026
94KIT0.22416227
95ITK0.22275022
96ADRBK10.21485994
97RPS6KB20.20967271
98CDK10.19359405
99CSNK1A10.18361796
100IGF1R0.16889553

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.05551856
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.64247276
3Protein export_Homo sapiens_hsa030603.62276791
4RNA polymerase_Homo sapiens_hsa030202.85450173
5Oxidative phosphorylation_Homo sapiens_hsa001902.76270166
6Ribosome_Homo sapiens_hsa030102.72460227
7Mismatch repair_Homo sapiens_hsa034302.61246832
8One carbon pool by folate_Homo sapiens_hsa006702.46764267
9Asthma_Homo sapiens_hsa053102.44274415
10DNA replication_Homo sapiens_hsa030302.40231594
11Parkinsons disease_Homo sapiens_hsa050122.28950977
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23840852
13Non-homologous end-joining_Homo sapiens_hsa034502.23493000
14Vitamin B6 metabolism_Homo sapiens_hsa007502.13571125
15Basal transcription factors_Homo sapiens_hsa030222.11337899
16RNA degradation_Homo sapiens_hsa030182.11168698
17RNA transport_Homo sapiens_hsa030132.03036565
18Homologous recombination_Homo sapiens_hsa034402.00974505
19Allograft rejection_Homo sapiens_hsa053301.92863720
20Spliceosome_Homo sapiens_hsa030401.80887144
21Autoimmune thyroid disease_Homo sapiens_hsa053201.71909579
22Nucleotide excision repair_Homo sapiens_hsa034201.69476877
23Pyrimidine metabolism_Homo sapiens_hsa002401.59720354
24Huntingtons disease_Homo sapiens_hsa050161.55698504
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53248650
26Propanoate metabolism_Homo sapiens_hsa006401.51644256
27Type I diabetes mellitus_Homo sapiens_hsa049401.48282757
28Alzheimers disease_Homo sapiens_hsa050101.44642692
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43561347
30Fanconi anemia pathway_Homo sapiens_hsa034601.42408195
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41913240
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.41694030
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37777500
34Base excision repair_Homo sapiens_hsa034101.31608240
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.23369458
36Graft-versus-host disease_Homo sapiens_hsa053321.22929262
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20870592
38Purine metabolism_Homo sapiens_hsa002301.17552977
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16937579
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16692142
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08616073
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06416268
43Sulfur metabolism_Homo sapiens_hsa009201.00145459
44Pyruvate metabolism_Homo sapiens_hsa006200.95692335
45Caffeine metabolism_Homo sapiens_hsa002320.90282804
46Antigen processing and presentation_Homo sapiens_hsa046120.88190699
47Phototransduction_Homo sapiens_hsa047440.85710397
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84771576
49Cell cycle_Homo sapiens_hsa041100.82781661
50Selenocompound metabolism_Homo sapiens_hsa004500.79987923
51Rheumatoid arthritis_Homo sapiens_hsa053230.79468958
52Primary immunodeficiency_Homo sapiens_hsa053400.70173442
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68015671
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67367736
55Epstein-Barr virus infection_Homo sapiens_hsa051690.67357184
56Cardiac muscle contraction_Homo sapiens_hsa042600.65639924
57Folate biosynthesis_Homo sapiens_hsa007900.65252486
58Steroid biosynthesis_Homo sapiens_hsa001000.64599421
59Collecting duct acid secretion_Homo sapiens_hsa049660.64404622
60p53 signaling pathway_Homo sapiens_hsa041150.60264952
61Metabolic pathways_Homo sapiens_hsa011000.57316790
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54905899
63Regulation of autophagy_Homo sapiens_hsa041400.54783405
64Tryptophan metabolism_Homo sapiens_hsa003800.54706421
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54481609
66Viral myocarditis_Homo sapiens_hsa054160.53178520
67mRNA surveillance pathway_Homo sapiens_hsa030150.51543277
68Fatty acid elongation_Homo sapiens_hsa000620.50733460
69Linoleic acid metabolism_Homo sapiens_hsa005910.48756610
70Hematopoietic cell lineage_Homo sapiens_hsa046400.47953762
71Peroxisome_Homo sapiens_hsa041460.47569972
72Glutathione metabolism_Homo sapiens_hsa004800.46866702
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46160998
74Carbon metabolism_Homo sapiens_hsa012000.44769144
75Butanoate metabolism_Homo sapiens_hsa006500.42801020
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41855274
77Legionellosis_Homo sapiens_hsa051340.41434868
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41057432
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40009728
80Measles_Homo sapiens_hsa051620.38500569
81Sulfur relay system_Homo sapiens_hsa041220.38429866
82Nitrogen metabolism_Homo sapiens_hsa009100.37410637
83Biosynthesis of amino acids_Homo sapiens_hsa012300.33651933
84Ether lipid metabolism_Homo sapiens_hsa005650.32493548
85Fatty acid degradation_Homo sapiens_hsa000710.31290961
86beta-Alanine metabolism_Homo sapiens_hsa004100.28130039
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26024686
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25537810
89Fat digestion and absorption_Homo sapiens_hsa049750.23964151
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.23017519
91Herpes simplex infection_Homo sapiens_hsa051680.22950658
92Oocyte meiosis_Homo sapiens_hsa041140.21569990
93Arginine and proline metabolism_Homo sapiens_hsa003300.21440652
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21187364
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.20609057
96T cell receptor signaling pathway_Homo sapiens_hsa046600.20456416
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18353412
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15797392
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15249565
100Fatty acid metabolism_Homo sapiens_hsa012120.13816460

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