HSPE1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.63176366
2ATP synthesis coupled proton transport (GO:0015986)7.29952809
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.29952809
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.95280356
5respiratory electron transport chain (GO:0022904)5.93448010
6electron transport chain (GO:0022900)5.81748360
7establishment of protein localization to mitochondrial membrane (GO:0090151)5.38511756
8protein complex biogenesis (GO:0070271)5.14320903
9ribosomal small subunit assembly (GO:0000028)5.10686246
10proteasome assembly (GO:0043248)4.87481915
11viral transcription (GO:0019083)4.79117209
12mitochondrial respiratory chain complex assembly (GO:0033108)4.72621790
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.71830772
14NADH dehydrogenase complex assembly (GO:0010257)4.71830772
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.71830772
16translational termination (GO:0006415)4.64160312
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.57548515
18cotranslational protein targeting to membrane (GO:0006613)4.48529781
19protein targeting to ER (GO:0045047)4.43728599
20hydrogen ion transmembrane transport (GO:1902600)4.35771324
21chaperone-mediated protein transport (GO:0072321)4.29049881
22protein localization to endoplasmic reticulum (GO:0070972)4.25261881
23establishment of protein localization to endoplasmic reticulum (GO:0072599)4.23430305
24ATP biosynthetic process (GO:0006754)4.19684285
25purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.19136065
26GTP biosynthetic process (GO:0006183)4.17400036
27purine nucleoside triphosphate biosynthetic process (GO:0009145)4.17223739
28tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.14505104
29RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.14505104
30ribosomal large subunit biogenesis (GO:0042273)3.95933590
31proton transport (GO:0015992)3.88572220
32translational elongation (GO:0006414)3.88446524
33hydrogen transport (GO:0006818)3.80994814
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.80972308
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.80588255
36regulation of oxidative phosphorylation (GO:0002082)3.80110238
37cytochrome complex assembly (GO:0017004)3.79998037
38oxidative phosphorylation (GO:0006119)3.79656126
39gonadal mesoderm development (GO:0007506)3.73825600
40respiratory chain complex IV assembly (GO:0008535)3.71891169
41translation (GO:0006412)3.67128029
42ribonucleoside triphosphate biosynthetic process (GO:0009201)3.66439313
43regulation of hypersensitivity (GO:0002883)3.59796006
44UTP biosynthetic process (GO:0006228)3.52490685
45positive regulation of mast cell activation involved in immune response (GO:0033008)3.49207362
46positive regulation of mast cell degranulation (GO:0043306)3.49207362
47protein neddylation (GO:0045116)3.49142446
48maturation of SSU-rRNA (GO:0030490)3.47960626
49regulation of cellular respiration (GO:0043457)3.46865175
50viral life cycle (GO:0019058)3.39217870
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.39105329
52cellular protein complex disassembly (GO:0043624)3.38186140
53translational initiation (GO:0006413)3.35351861
54positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.35190944
55positive regulation of mast cell activation (GO:0033005)3.27893555
56base-excision repair, AP site formation (GO:0006285)3.25113173
57nucleoside triphosphate biosynthetic process (GO:0009142)3.23272725
58UTP metabolic process (GO:0046051)3.19834560
59DNA deamination (GO:0045006)3.19735637
60regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.17534792
61aldehyde catabolic process (GO:0046185)3.14069765
62antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.08621097
63spliceosomal complex assembly (GO:0000245)3.02307143
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02168704
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99856440
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.98100191
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97786257
68regulation of cellular amino acid metabolic process (GO:0006521)2.97133540
69protein targeting to membrane (GO:0006612)2.97062143
70CTP metabolic process (GO:0046036)2.94060014
71CTP biosynthetic process (GO:0006241)2.94060014
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.93038203
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.93038203
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.93038203
75purine deoxyribonucleotide catabolic process (GO:0009155)2.91074712
76regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90421834
77intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.90112324
78signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.90112324
79purine nucleoside monophosphate biosynthetic process (GO:0009127)2.84195625
80purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.84195625
81signal transduction involved in DNA integrity checkpoint (GO:0072401)2.80857011
82signal transduction involved in DNA damage checkpoint (GO:0072422)2.80857011
83RNA phosphodiester bond hydrolysis (GO:0090501)2.80256518
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.78616902
85negative regulation of ligase activity (GO:0051352)2.78616902
86energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.78075329
87ATP hydrolysis coupled proton transport (GO:0015991)2.78075329
88signal transduction involved in cell cycle checkpoint (GO:0072395)2.77656152
89platelet dense granule organization (GO:0060155)2.75604678
90cellular component biogenesis (GO:0044085)2.75564304
91nuclear-transcribed mRNA catabolic process (GO:0000956)2.75356514
92one-carbon compound transport (GO:0019755)2.74681035
93protein targeting to mitochondrion (GO:0006626)2.73625070
94RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73349680
95protein complex disassembly (GO:0043241)2.73278034
96pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72962746
97cellular respiration (GO:0045333)2.72496540
98guanosine-containing compound biosynthetic process (GO:1901070)2.72211228
99deoxyribose phosphate catabolic process (GO:0046386)2.71840660
100protein localization to mitochondrion (GO:0070585)2.71823725

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.74332299
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.64822637
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.43699392
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.21721220
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01259467
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.98960612
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.87297055
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83503867
9VDR_23849224_ChIP-Seq_CD4+_Human2.80639862
10ELK1_19687146_ChIP-ChIP_HELA_Human2.63397526
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.61104283
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.60695557
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48278378
14VDR_22108803_ChIP-Seq_LS180_Human2.44413764
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29854979
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.23992494
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21791669
18TAF15_26573619_Chip-Seq_HEK293_Human2.17115828
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.13830111
20FOXP3_21729870_ChIP-Seq_TREG_Human2.08489154
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02130359
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72347987
23ZNF274_21170338_ChIP-Seq_K562_Hela1.72319543
24EZH2_22144423_ChIP-Seq_EOC_Human1.70630819
25TP53_22573176_ChIP-Seq_HFKS_Human1.65106414
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62800633
27EWS_26573619_Chip-Seq_HEK293_Human1.62202821
28TTF2_22483619_ChIP-Seq_HELA_Human1.60771762
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.57507436
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57178592
31IGF1R_20145208_ChIP-Seq_DFB_Human1.55788135
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53198166
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52960178
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51150232
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47811416
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46458806
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46056978
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45414638
39ERG_20517297_ChIP-Seq_VCAP_Human1.36601588
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34813647
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34338567
42MYC_18940864_ChIP-ChIP_HL60_Human1.34316226
43GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30925080
44P300_19829295_ChIP-Seq_ESCs_Human1.29080536
45CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27640339
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.27306541
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27306541
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26851842
49DCP1A_22483619_ChIP-Seq_HELA_Human1.26620797
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24046778
51IRF1_19129219_ChIP-ChIP_H3396_Human1.23722427
52GABP_19822575_ChIP-Seq_HepG2_Human1.22920537
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22814018
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.18222272
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17699044
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16738567
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.16336048
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15635390
59FUS_26573619_Chip-Seq_HEK293_Human1.15365001
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15171535
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14660085
62CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14536151
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14501485
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12523612
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10327216
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10295734
67TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10234519
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.09957290
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.07059382
70AR_20517297_ChIP-Seq_VCAP_Human1.06965207
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06462514
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05387809
73FOXH1_21741376_ChIP-Seq_EPCs_Human1.05302004
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04796131
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03683796
76ER_23166858_ChIP-Seq_MCF-7_Human1.03556973
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02242996
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01993519
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99550830
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97695531
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96622368
82PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95713740
83NANOG_19829295_ChIP-Seq_ESCs_Human0.95528062
84SOX2_19829295_ChIP-Seq_ESCs_Human0.95528062
85CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95264933
86CBP_20019798_ChIP-Seq_JUKART_Human0.95171702
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95171702
88TAF2_19829295_ChIP-Seq_ESCs_Human0.95007786
89ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94888484
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94845476
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94493030
92NCOR_22424771_ChIP-Seq_293T_Human0.93577959
93GATA3_26560356_Chip-Seq_TH2_Human0.93503519
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92962300
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92333421
96TCF4_22108803_ChIP-Seq_LS180_Human0.90099297
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88799324
98HOXB7_26014856_ChIP-Seq_BT474_Human0.87336460
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87080259
100POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86677386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.56333282
2MP0009379_abnormal_foot_pigmentation4.36235823
3MP0002837_dystrophic_cardiac_calcinosis3.69398574
4MP0001835_abnormal_antigen_presentation3.13621963
5MP0001529_abnormal_vocalization3.11299689
6MP0008877_abnormal_DNA_methylation2.63872104
7MP0003787_abnormal_imprinting2.44128388
8MP0006072_abnormal_retinal_apoptosis2.36213837
9MP0003646_muscle_fatigue2.36037339
10MP0006036_abnormal_mitochondrial_physio2.27174244
11MP0005671_abnormal_response_to2.22451904
12MP0002102_abnormal_ear_morphology2.15761184
13MP0002163_abnormal_gland_morphology2.14333702
14MP0003186_abnormal_redox_activity2.04518496
15MP0000372_irregular_coat_pigmentation2.01301664
16MP0004142_abnormal_muscle_tone1.99663823
17MP0008995_early_reproductive_senescence1.95156679
18MP0005367_renal/urinary_system_phenotyp1.86018984
19MP0000516_abnormal_urinary_system1.86018984
20MP0008875_abnormal_xenobiotic_pharmacok1.82797759
21MP0005423_abnormal_somatic_nervous1.81489095
22MP0008872_abnormal_physiological_respon1.81399595
23MP0005075_abnormal_melanosome_morpholog1.75490146
24MP0005379_endocrine/exocrine_gland_phen1.67761050
25MP0004145_abnormal_muscle_electrophysio1.62660170
26MP0009764_decreased_sensitivity_to1.61921630
27MP0001919_abnormal_reproductive_system1.60827739
28MP0006292_abnormal_olfactory_placode1.48554371
29MP0000569_abnormal_digit_pigmentation1.43282318
30MP0001905_abnormal_dopamine_level1.42879820
31MP0005253_abnormal_eye_physiology1.40251467
32MP0001968_abnormal_touch/_nociception1.38131665
33MP0005551_abnormal_eye_electrophysiolog1.31380507
34MP0008058_abnormal_DNA_repair1.31157635
35MP0002090_abnormal_vision1.27557204
36MP0002736_abnormal_nociception_after1.27081909
37MP0003121_genomic_imprinting1.26985445
38MP0003786_premature_aging1.26162683
39MP0003195_calcinosis1.26121000
40MP0001800_abnormal_humoral_immune1.25262950
41MP0003567_abnormal_fetal_cardiomyocyte1.25130641
42MP0005389_reproductive_system_phenotype1.24253282
43MP0001727_abnormal_embryo_implantation1.23205024
44MP0002272_abnormal_nervous_system1.22205402
45MP0009046_muscle_twitch1.21064055
46MP0001440_abnormal_grooming_behavior1.20953253
47MP0005645_abnormal_hypothalamus_physiol1.19185903
48MP0003252_abnormal_bile_duct1.16700299
49MP0006082_CNS_inflammation1.15578687
50MP0001984_abnormal_olfaction1.15555494
51MP0002160_abnormal_reproductive_system1.14269664
52MP0003880_abnormal_central_pattern1.14109806
53MP0002234_abnormal_pharynx_morphology1.12608841
54MP0001486_abnormal_startle_reflex1.10922932
55MP0009785_altered_susceptibility_to1.10756455
56MP0005646_abnormal_pituitary_gland1.10615581
57MP0006276_abnormal_autonomic_nervous1.10049584
58MP0001756_abnormal_urination1.07350694
59MP0005410_abnormal_fertilization1.06570983
60MP0002876_abnormal_thyroid_physiology1.05714937
61MP0001485_abnormal_pinna_reflex1.04995766
62MP0005408_hypopigmentation1.03371421
63MP0008789_abnormal_olfactory_epithelium1.03124807
64MP0009745_abnormal_behavioral_response1.03062076
65MP0002148_abnormal_hypersensitivity_rea1.02853478
66MP0005332_abnormal_amino_acid1.02312518
67MP0002095_abnormal_skin_pigmentation0.99258577
68MP0000639_abnormal_adrenal_gland0.97822300
69MP0005386_behavior/neurological_phenoty0.94380920
70MP0004924_abnormal_behavior0.94380920
71MP0004019_abnormal_vitamin_homeostasis0.90541874
72MP0001970_abnormal_pain_threshold0.89442083
73MP0005636_abnormal_mineral_homeostasis0.88568326
74MP0005377_hearing/vestibular/ear_phenot0.87579036
75MP0003878_abnormal_ear_physiology0.87579036
76MP0004742_abnormal_vestibular_system0.87432589
77MP0006035_abnormal_mitochondrial_morpho0.87051941
78MP0003137_abnormal_impulse_conducting0.86943266
79MP0002557_abnormal_social/conspecific_i0.85070055
80MP0004215_abnormal_myocardial_fiber0.84614188
81MP0005394_taste/olfaction_phenotype0.83504458
82MP0005499_abnormal_olfactory_system0.83504458
83MP0001986_abnormal_taste_sensitivity0.83440037
84MP0002229_neurodegeneration0.82966097
85MP0005266_abnormal_metabolism0.82877271
86MP0005084_abnormal_gallbladder_morpholo0.81858237
87MP0002822_catalepsy0.81472577
88MP0005174_abnormal_tail_pigmentation0.80931768
89MP0009333_abnormal_splenocyte_physiolog0.78367164
90MP0004885_abnormal_endolymph0.78017781
91MP0002452_abnormal_antigen_presenting0.77371395
92MP0000427_abnormal_hair_cycle0.76162069
93MP0005000_abnormal_immune_tolerance0.75875913
94MP0008775_abnormal_heart_ventricle0.75705639
95MP0001873_stomach_inflammation0.74967229
96MP0001765_abnormal_ion_homeostasis0.73576350
97MP0002723_abnormal_immune_serum0.73332992
98MP0003638_abnormal_response/metabolism_0.72515902
99MP0003315_abnormal_perineum_morphology0.71829788
100MP0001764_abnormal_homeostasis0.71641021

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.89078170
2Abnormal mitochondria in muscle tissue (HP:0008316)6.06089430
3Mitochondrial inheritance (HP:0001427)5.87142807
4Progressive macrocephaly (HP:0004481)5.75637205
5Acute encephalopathy (HP:0006846)5.69257276
6Hepatocellular necrosis (HP:0001404)5.56043753
7Increased CSF lactate (HP:0002490)5.23553783
8Hepatic necrosis (HP:0002605)4.92260593
9Congenital, generalized hypertrichosis (HP:0004540)4.29628192
10Cerebral edema (HP:0002181)4.17381133
11Increased hepatocellular lipid droplets (HP:0006565)3.98318343
123-Methylglutaconic aciduria (HP:0003535)3.96752950
13Lipid accumulation in hepatocytes (HP:0006561)3.75867424
14Leukodystrophy (HP:0002415)3.65686342
15Renal Fanconi syndrome (HP:0001994)3.50833735
16Respiratory failure (HP:0002878)3.36638708
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.35706650
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.35706650
19Exertional dyspnea (HP:0002875)3.29162492
20Optic disc pallor (HP:0000543)3.25204996
21Increased serum lactate (HP:0002151)3.10108179
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.06717272
23Lactic acidosis (HP:0003128)3.00569412
24Increased intramyocellular lipid droplets (HP:0012240)2.89128686
25Reticulocytopenia (HP:0001896)2.83849063
26Exercise intolerance (HP:0003546)2.67665412
27Macrocytic anemia (HP:0001972)2.65952283
28Stomatitis (HP:0010280)2.56675559
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.56280139
30Myokymia (HP:0002411)2.52191167
31Abnormality of renal resorption (HP:0011038)2.50773349
32Abolished electroretinogram (ERG) (HP:0000550)2.48143543
33Increased muscle lipid content (HP:0009058)2.43665010
34Molar tooth sign on MRI (HP:0002419)2.41714715
35Abnormality of midbrain morphology (HP:0002418)2.41714715
36Abnormality of the prostate (HP:0008775)2.33665872
37X-linked dominant inheritance (HP:0001423)2.33431061
38Pancreatic cysts (HP:0001737)2.33183641
39CNS demyelination (HP:0007305)2.30973545
40Medial flaring of the eyebrow (HP:0010747)2.30109059
41Respiratory difficulties (HP:0002880)2.26866197
42Lethargy (HP:0001254)2.26548535
43Hypothermia (HP:0002045)2.24059098
44Colon cancer (HP:0003003)2.19647835
45Abnormality of urine glucose concentration (HP:0011016)2.17812415
46Glycosuria (HP:0003076)2.17812415
47Hyperphosphaturia (HP:0003109)2.08000327
48Abnormality of cells of the erythroid lineage (HP:0012130)2.00010441
49Woolly hair (HP:0002224)1.92995825
50Gait imbalance (HP:0002141)1.92817129
51Porencephaly (HP:0002132)1.92741073
52Congenital stationary night blindness (HP:0007642)1.92481263
53Sclerocornea (HP:0000647)1.91700639
54Progressive microcephaly (HP:0000253)1.91622471
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.91358057
56Absent/shortened dynein arms (HP:0200106)1.89604790
57Dynein arm defect of respiratory motile cilia (HP:0012255)1.89604790
58Congenital primary aphakia (HP:0007707)1.88095640
59Male pseudohermaphroditism (HP:0000037)1.85053299
60Cleft eyelid (HP:0000625)1.84799464
61Obstructive lung disease (HP:0006536)1.83109149
62Chronic obstructive pulmonary disease (HP:0006510)1.83109149
63Abnormal rod and cone electroretinograms (HP:0008323)1.82907499
64Nephrogenic diabetes insipidus (HP:0009806)1.82746334
65Sensory axonal neuropathy (HP:0003390)1.82738318
66Emotional lability (HP:0000712)1.79220792
67Abnormality of the anterior horn cell (HP:0006802)1.78750545
68Degeneration of anterior horn cells (HP:0002398)1.78750545
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74601575
70Abnormality of alanine metabolism (HP:0010916)1.74601575
71Hyperalaninemia (HP:0003348)1.74601575
72Delayed CNS myelination (HP:0002188)1.72915941
73Agitation (HP:0000713)1.72355720
74Abnormal respiratory motile cilium physiology (HP:0012261)1.72205146
75Blindness (HP:0000618)1.71322321
76Hypomagnesemia (HP:0002917)1.68800867
77Aplasia/hypoplasia of the uterus (HP:0008684)1.67265162
78Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66470344
79Gliosis (HP:0002171)1.65256402
80Nephronophthisis (HP:0000090)1.64595059
81Absent rod-and cone-mediated responses on ERG (HP:0007688)1.64181623
82Decreased electroretinogram (ERG) amplitude (HP:0000654)1.63306859
83Abnormality of magnesium homeostasis (HP:0004921)1.63242540
84Hypoproteinemia (HP:0003075)1.62387550
85Pendular nystagmus (HP:0012043)1.60527724
86Pallor (HP:0000980)1.59961162
87Neoplasm of the adrenal cortex (HP:0100641)1.59416051
88Abnormality of male internal genitalia (HP:0000022)1.57126245
89Absent thumb (HP:0009777)1.55475201
90Abnormal respiratory motile cilium morphology (HP:0005938)1.55378746
91Abnormal respiratory epithelium morphology (HP:0012253)1.55378746
92IgG deficiency (HP:0004315)1.54869444
93Rectal fistula (HP:0100590)1.53150609
94Rectovaginal fistula (HP:0000143)1.53150609
95Abnormality of the renal medulla (HP:0100957)1.53131185
96Metaphyseal dysplasia (HP:0100255)1.51909409
97Parakeratosis (HP:0001036)1.51314293
98Vomiting (HP:0002013)1.51047340
99Neoplasm of the adrenal gland (HP:0100631)1.49703715
100Pancreatic fibrosis (HP:0100732)1.49668262

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.46518105
2VRK23.24423135
3BMPR23.17124269
4CDK192.53270289
5STK162.27692311
6MAP4K22.22217819
7ZAK2.17276878
8MYLK2.13912040
9FRK2.12614769
10MST42.05454397
11SRPK12.02419640
12TAF11.94011297
13EIF2AK31.89100580
14DYRK21.81027234
15NUAK11.69132984
16ADRBK21.67706938
17WNK41.64586116
18OXSR11.63315672
19NEK11.61766320
20EIF2AK11.61173276
21TLK11.56149675
22VRK11.51315861
23TAOK31.50383356
24DAPK11.46935240
25ILK1.40092423
26GRK11.32430902
27RIPK41.27794660
28TXK1.25682327
29DAPK31.24373591
30TEC1.20227784
31TIE11.18978443
32CAMKK21.16997355
33PBK1.14353660
34CSNK1G31.13144287
35PLK41.12764193
36TSSK61.11308443
37NME11.08711617
38CSNK1G21.07751178
39INSRR1.04613451
40PLK31.01546615
41ERBB30.97369630
42MKNK20.96562744
43CDK80.95236539
44WNK30.94965758
45IKBKB0.92543967
46CSNK1A1L0.90252577
47ABL20.89580101
48DAPK20.88920989
49PIK3CG0.84237780
50MAP2K70.83092613
51MINK10.82523206
52TNK20.81167449
53PHKG10.78295997
54PHKG20.78295997
55CSNK1G10.78121530
56GRK70.72654730
57CSF1R0.72133616
58LYN0.71594523
59PLK20.70417572
60ITK0.68935608
61KIT0.67690264
62PNCK0.66126919
63ACVR1B0.64495029
64GRK50.64003450
65MAP3K40.63729616
66AURKB0.61216328
67BCKDK0.60444461
68ATR0.58598051
69PAK30.58407559
70CSNK2A20.57935794
71BTK0.57540738
72PAK40.57019700
73EIF2AK20.56918462
74CHEK20.56863880
75PRKCG0.55723696
76ADRBK10.55013021
77BMPR1B0.53920685
78STK390.53257781
79PRKCE0.53227692
80PDK20.52858368
81MKNK10.52777929
82CSNK1A10.51884487
83NME20.49521679
84TRIM280.49252603
85PRKACA0.47277521
86SYK0.45884077
87PLK10.45384592
88OBSCN0.44501841
89PKN10.42758876
90DYRK30.42027554
91CSNK2A10.41823747
92SCYL20.41773809
93MAPK130.40083912
94PRKCD0.38958368
95PRKG10.38603062
96CCNB10.38428760
97PINK10.38068320
98TRPM70.37690607
99MAP2K40.37007299
100CDK30.34729396

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.79875675
2Asthma_Homo sapiens_hsa053104.58231968
3Ribosome_Homo sapiens_hsa030103.88082413
4Parkinsons disease_Homo sapiens_hsa050123.83553945
5Proteasome_Homo sapiens_hsa030503.57154697
6Allograft rejection_Homo sapiens_hsa053302.98043605
7Protein export_Homo sapiens_hsa030602.91506161
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.88578571
9Autoimmune thyroid disease_Homo sapiens_hsa053202.87605101
10Alzheimers disease_Homo sapiens_hsa050102.76297395
11Huntingtons disease_Homo sapiens_hsa050162.58878364
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.37307881
13Cardiac muscle contraction_Homo sapiens_hsa042602.36011371
14Graft-versus-host disease_Homo sapiens_hsa053322.25423407
15Type I diabetes mellitus_Homo sapiens_hsa049402.23393934
16Homologous recombination_Homo sapiens_hsa034402.01141513
17Rheumatoid arthritis_Homo sapiens_hsa053231.84023583
18Mismatch repair_Homo sapiens_hsa034301.81330802
19Collecting duct acid secretion_Homo sapiens_hsa049661.71152567
20DNA replication_Homo sapiens_hsa030301.56028159
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50651138
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48500065
23RNA degradation_Homo sapiens_hsa030181.48437583
24RNA polymerase_Homo sapiens_hsa030201.40814494
25Viral myocarditis_Homo sapiens_hsa054161.39303112
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36749941
27Antigen processing and presentation_Homo sapiens_hsa046121.25750764
28Nucleotide excision repair_Homo sapiens_hsa034201.14490388
29Staphylococcus aureus infection_Homo sapiens_hsa051501.10009505
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93564537
31Spliceosome_Homo sapiens_hsa030400.91267699
32Propanoate metabolism_Homo sapiens_hsa006400.90730999
33Linoleic acid metabolism_Homo sapiens_hsa005910.89316119
34Fanconi anemia pathway_Homo sapiens_hsa034600.84114329
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84046963
36Phototransduction_Homo sapiens_hsa047440.83463624
37Regulation of autophagy_Homo sapiens_hsa041400.82748014
38Pyrimidine metabolism_Homo sapiens_hsa002400.82714906
39Base excision repair_Homo sapiens_hsa034100.80951061
40RNA transport_Homo sapiens_hsa030130.80943759
41Tryptophan metabolism_Homo sapiens_hsa003800.76013759
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74314701
43Phagosome_Homo sapiens_hsa041450.73475966
44Basal transcription factors_Homo sapiens_hsa030220.72987601
45Leishmaniasis_Homo sapiens_hsa051400.70813710
46Systemic lupus erythematosus_Homo sapiens_hsa053220.68887771
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68196192
48Non-homologous end-joining_Homo sapiens_hsa034500.65393373
49Vibrio cholerae infection_Homo sapiens_hsa051100.64674242
50Peroxisome_Homo sapiens_hsa041460.62758209
51One carbon pool by folate_Homo sapiens_hsa006700.61417419
52Purine metabolism_Homo sapiens_hsa002300.59994412
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.59130232
54Ether lipid metabolism_Homo sapiens_hsa005650.58204305
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57159863
56Arachidonic acid metabolism_Homo sapiens_hsa005900.56546358
57Metabolic pathways_Homo sapiens_hsa011000.52557821
58Fatty acid elongation_Homo sapiens_hsa000620.51763368
59Olfactory transduction_Homo sapiens_hsa047400.51369251
60Pyruvate metabolism_Homo sapiens_hsa006200.51007055
61Glutathione metabolism_Homo sapiens_hsa004800.50748775
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46924819
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.46173928
64Caffeine metabolism_Homo sapiens_hsa002320.44300584
65Tuberculosis_Homo sapiens_hsa051520.43689671
66Hematopoietic cell lineage_Homo sapiens_hsa046400.43153266
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42678886
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42324333
69Synaptic vesicle cycle_Homo sapiens_hsa047210.41782839
70Butanoate metabolism_Homo sapiens_hsa006500.40758822
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.36865141
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36848554
73Primary immunodeficiency_Homo sapiens_hsa053400.36642040
74beta-Alanine metabolism_Homo sapiens_hsa004100.35965216
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34640450
76Chemical carcinogenesis_Homo sapiens_hsa052040.34014063
77Legionellosis_Homo sapiens_hsa051340.33957061
78Sulfur metabolism_Homo sapiens_hsa009200.30539469
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30397795
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29188847
81p53 signaling pathway_Homo sapiens_hsa041150.29070988
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28951642
83Nicotine addiction_Homo sapiens_hsa050330.27586764
84Fatty acid degradation_Homo sapiens_hsa000710.27439441
85Steroid biosynthesis_Homo sapiens_hsa001000.27418200
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.26750397
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26619892
88Fat digestion and absorption_Homo sapiens_hsa049750.26464023
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.26173982
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24791406
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23592718
92Epstein-Barr virus infection_Homo sapiens_hsa051690.23316870
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.22541804
94GABAergic synapse_Homo sapiens_hsa047270.22445633
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20715902
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19437113
97Taste transduction_Homo sapiens_hsa047420.18857849
98Morphine addiction_Homo sapiens_hsa050320.17096268
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13918055
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.13685453

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