ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	6.29735919
2	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	6.02359134
3	protein neddylation (GO:0045116)	5.78835448
4	ribosomal small subunit assembly (GO:0000028)	5.65323057
5	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	5.10081684
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.09728228
7	ATP synthesis coupled proton transport (GO:0015986)	5.09728228
8	GTP biosynthetic process (GO:0006183)	4.91224665
9	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.86146710
10	DNA deamination (GO:0045006)	4.86142741
11	regulation of immunoglobulin secretion (GO:0051023)	4.85103221
12	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.61485988
13	regulation of isotype switching to IgG isotypes (GO:0048302)	4.60443626
14	proteasome assembly (GO:0043248)	4.44216053
15	UTP biosynthetic process (GO:0006228)	4.39295286
16	UTP metabolic process (GO:0046051)	4.17191585
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.09224198
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.09224198
19	NADH dehydrogenase complex assembly (GO:0010257)	4.09224198
20	protein complex biogenesis (GO:0070271)	4.05921152
21	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.04826017
22	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.04826017
23	mitochondrial respiratory chain complex assembly (GO:0033108)	4.00449006
24	protein targeting to mitochondrion (GO:0006626)	3.72400674
25	peptidyl-histidine modification (GO:0018202)	3.71155025
26	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.67622265
27	respiratory electron transport chain (GO:0022904)	3.65337038
28	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.64296841
29	termination of RNA polymerase III transcription (GO:0006386)	3.64296841
30	electron transport chain (GO:0022900)	3.62854265
31	guanosine-containing compound biosynthetic process (GO:1901070)	3.60252661
32	regulation of chronic inflammatory response (GO:0002676)	3.57403386
33	behavioral response to nicotine (GO:0035095)	3.57346943
34	ncRNA 3-end processing (GO:0043628)	3.55268916
35	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.49939985
36	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.46510279
37	tRNA processing (GO:0008033)	3.46370750
38	DNA methylation involved in gamete generation (GO:0043046)	3.40343255
39	positive regulation of isotype switching (GO:0045830)	3.34854637
40	ribosomal small subunit biogenesis (GO:0042274)	3.34370576
41	peptidyl-threonine dephosphorylation (GO:0035970)	3.34263465
42	CTP biosynthetic process (GO:0006241)	3.32900559
43	CTP metabolic process (GO:0046036)	3.32900559
44	establishment of protein localization to mitochondrion (GO:0072655)	3.31870861
45	protein localization to mitochondrion (GO:0070585)	3.29980830
46	transcription from mitochondrial promoter (GO:0006390)	3.24945395
47	negative regulation of B cell apoptotic process (GO:0002903)	3.22787563
48	positive regulation of DNA recombination (GO:0045911)	3.18530473
49	rRNA processing (GO:0006364)	3.17001631
50	regulation of regulatory T cell differentiation (GO:0045589)	3.14190987
51	respiratory chain complex IV assembly (GO:0008535)	3.13902802
52	DNA damage response, detection of DNA damage (GO:0042769)	3.13099009
53	water-soluble vitamin biosynthetic process (GO:0042364)	3.12981816
54	intracellular protein transmembrane import (GO:0044743)	3.10453084
55	tRNA metabolic process (GO:0006399)	3.09017137
56	piRNA metabolic process (GO:0034587)	3.08058535
57	rRNA modification (GO:0000154)	3.06918029
58	cellular component biogenesis (GO:0044085)	3.05955903
59	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.04823648
60	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.04191791
61	rRNA metabolic process (GO:0016072)	3.04006269
62	sphingosine metabolic process (GO:0006670)	3.03217791
63	pseudouridine synthesis (GO:0001522)	3.02908520
64	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.01897683
65	chromatin remodeling at centromere (GO:0031055)	3.01688124
66	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.00970086
67	ATP biosynthetic process (GO:0006754)	3.00811000
68	hydrogen ion transmembrane transport (GO:1902600)	3.00303093
69	translation (GO:0006412)	2.99444013
70	mitochondrial RNA metabolic process (GO:0000959)	2.99256415
71	protein-cofactor linkage (GO:0018065)	2.96538514
72	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.95318664
73	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.95015563
74	maturation of SSU-rRNA (GO:0030490)	2.92265697
75	7-methylguanosine mRNA capping (GO:0006370)	2.92017269
76	inner mitochondrial membrane organization (GO:0007007)	2.91929185
77	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.90535796
78	DNA double-strand break processing (GO:0000729)	2.88434294
79	nucleoside diphosphate phosphorylation (GO:0006165)	2.87710699
80	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.87400126
81	ribonucleoprotein complex biogenesis (GO:0022613)	2.86991348
82	7-methylguanosine RNA capping (GO:0009452)	2.86556166
83	RNA capping (GO:0036260)	2.86556166
84	proton transport (GO:0015992)	2.86481783
85	translational termination (GO:0006415)	2.85408512
86	protein polyglutamylation (GO:0018095)	2.84411922
87	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.82319169
88	hydrogen transport (GO:0006818)	2.80585207
89	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.80570561
90	positive regulation of B cell mediated immunity (GO:0002714)	2.80570561
91	CENP-A containing nucleosome assembly (GO:0034080)	2.79919591
92	organelle disassembly (GO:1903008)	2.79611535
93	ribosome biogenesis (GO:0042254)	2.79031166
94	ncRNA processing (GO:0034470)	2.78389408
95	regulation of meiosis I (GO:0060631)	2.77550270
96	ribosomal large subunit biogenesis (GO:0042273)	2.76519401
97	viral transcription (GO:0019083)	2.74542258
98	ncRNA metabolic process (GO:0034660)	2.72941611
99	diol metabolic process (GO:0034311)	2.71055771
100	positive regulation of interleukin-17 production (GO:0032740)	2.68382843

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.79835241
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.44516812
3	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.20510003
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.18071400
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.04639840
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.04163252
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.87169506
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.82302427
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.74258677
10	VDR_22108803_ChIP-Seq_LS180_Human	2.67355811
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.53489946
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.35396949
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.35142674
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.32829986
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.09859300
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.08388361
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.02117131
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.99369374
19	ELK1_19687146_ChIP-ChIP_HELA_Human	1.98966726
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.96824399
21	FOXP3_21729870_ChIP-Seq_TREG_Human	1.93947169
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.83897949
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.83715027
24	EWS_26573619_Chip-Seq_HEK293_Human	1.74494595
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.67718285
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62927663
27	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.60762727
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.57846718
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.55448937
30	AR_21572438_ChIP-Seq_LNCaP_Human	1.53931713
31	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.53826653
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.52136324
33	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.52060502
34	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.51749708
35	TTF2_22483619_ChIP-Seq_HELA_Human	1.51210772
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.50820416
37	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.48779820
38	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.48268541
39	GABP_19822575_ChIP-Seq_HepG2_Human	1.47551372
40	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.40952104
41	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.38868533
42	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.38121457
43	P300_19829295_ChIP-Seq_ESCs_Human	1.35946968
44	IRF1_19129219_ChIP-ChIP_H3396_Human	1.35741948
45	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.35598702
46	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.32324858
47	NCOR_22424771_ChIP-Seq_293T_Human	1.31367613
48	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.31242105
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31068634
50	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.29805115
51	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.28883053
52	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.28093150
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26852314
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26852314
55	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.26275290
56	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25611921
57	XRN2_22483619_ChIP-Seq_HELA_Human	1.25452831
58	DCP1A_22483619_ChIP-Seq_HELA_Human	1.24969306
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24417852
60	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.22668784
61	ER_23166858_ChIP-Seq_MCF-7_Human	1.22262161
62	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.21864216
63	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.21553585
64	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.21138095
65	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.21001979
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17252343
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13727492
68	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.12550977
69	TAF15_26573619_Chip-Seq_HEK293_Human	1.12384457
70	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12202419
71	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12202419
72	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.11252129
73	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.10734657
74	FUS_26573619_Chip-Seq_HEK293_Human	1.09662705
75	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.07578739
76	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.04627480
77	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01938757
78	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01856359
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01588808
80	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.96786767
81	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96590542
82	TCF4_22108803_ChIP-Seq_LS180_Human	0.94221893
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.91898516
84	MYC_19829295_ChIP-Seq_ESCs_Human	0.91398113
85	GBX2_23144817_ChIP-Seq_PC3_Human	0.90021882
86	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.89281826
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.87404959
88	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.87088488
89	NANOG_20526341_ChIP-Seq_ESCs_Human	0.86786435
90	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.86783147
91	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.86417320
92	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.85624439
93	ERG_20517297_ChIP-Seq_VCAP_Human	0.83659745
94	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.83524261
95	CBP_20019798_ChIP-Seq_JUKART_Human	0.83270296
96	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.83270296
97	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.83080959
98	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.82639991
99	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.81922119
100	P53_21459846_ChIP-Seq_SAOS-2_Human	0.81652733

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	4.63752857
2	MP0006292_abnormal_olfactory_placode	3.97257630
3	MP0002653_abnormal_ependyma_morphology	3.63112657
4	MP0003136_yellow_coat_color	3.16532404
5	MP0001348_abnormal_lacrimal_gland	2.58998752
6	MP0004147_increased_porphyrin_level	2.48523830
7	MP0003646_muscle_fatigue	2.42997244
8	MP0008877_abnormal_DNA_methylation	2.31977599
9	MP0002160_abnormal_reproductive_system	2.23669359
10	MP0002138_abnormal_hepatobiliary_system	2.14617381
11	MP0005171_absent_coat_pigmentation	2.01136933
12	MP0003786_premature_aging	1.90690040
13	MP0003890_abnormal_embryonic-extraembry	1.83063756
14	MP0002102_abnormal_ear_morphology	1.82779410
15	MP0004742_abnormal_vestibular_system	1.77050649
16	MP0008875_abnormal_xenobiotic_pharmacok	1.70947082
17	MP0008058_abnormal_DNA_repair	1.67358001
18	MP0005085_abnormal_gallbladder_physiolo	1.65675876
19	MP0004142_abnormal_muscle_tone	1.63083741
20	MP0002234_abnormal_pharynx_morphology	1.60724970
21	MP0005389_reproductive_system_phenotype	1.58409304
22	MP0001984_abnormal_olfaction	1.57949828
23	MP0008872_abnormal_physiological_respon	1.55301000
24	MP0008789_abnormal_olfactory_epithelium	1.50660961
25	MP0002938_white_spotting	1.44368378
26	MP0002736_abnormal_nociception_after	1.43569697
27	MP0009745_abnormal_behavioral_response	1.39206641
28	MP0004145_abnormal_muscle_electrophysio	1.38323021
29	MP0004957_abnormal_blastocyst_morpholog	1.38124998
30	MP0001835_abnormal_antigen_presentation	1.37522698
31	MP0002876_abnormal_thyroid_physiology	1.37170170
32	MP0003195_calcinosis	1.36909577
33	MP0001529_abnormal_vocalization	1.35225144
34	MP0000604_amyloidosis	1.34956822
35	MP0004885_abnormal_endolymph	1.34691172
36	MP0006276_abnormal_autonomic_nervous	1.32883471
37	MP0003718_maternal_effect	1.32610366
38	MP0001968_abnormal_touch/_nociception	1.29390621
39	MP0003315_abnormal_perineum_morphology	1.29056691
40	MP0002272_abnormal_nervous_system	1.27646059
41	MP0002735_abnormal_chemical_nociception	1.27085534
42	MP0004381_abnormal_hair_follicle	1.26794904
43	MP0004043_abnormal_pH_regulation	1.24844688
44	MP0003879_abnormal_hair_cell	1.23505195
45	MP0001501_abnormal_sleep_pattern	1.22553927
46	MP0000049_abnormal_middle_ear	1.21299430
47	MP0001485_abnormal_pinna_reflex	1.20576492
48	MP0001970_abnormal_pain_threshold	1.20317595
49	MP0003878_abnormal_ear_physiology	1.20015751
50	MP0005377_hearing/vestibular/ear_phenot	1.20015751
51	MP0005551_abnormal_eye_electrophysiolog	1.19723052
52	MP0003119_abnormal_digestive_system	1.19576919
53	MP0006036_abnormal_mitochondrial_physio	1.18498533
54	MP0006072_abnormal_retinal_apoptosis	1.18107481
55	MP0002751_abnormal_autonomic_nervous	1.17822097
56	MP0001881_abnormal_mammary_gland	1.17588327
57	MP0002733_abnormal_thermal_nociception	1.17524533
58	MP0005646_abnormal_pituitary_gland	1.17315817
59	MP0002638_abnormal_pupillary_reflex	1.17137046
60	MP0005671_abnormal_response_to	1.14926624
61	MP0003300_gastrointestinal_ulcer	1.14461685
62	MP0001486_abnormal_startle_reflex	1.08611705
63	MP0009379_abnormal_foot_pigmentation	1.08067449
64	MP0001919_abnormal_reproductive_system	1.04519770
65	MP0003186_abnormal_redox_activity	1.03855729
66	MP0003693_abnormal_embryo_hatching	1.03684427
67	MP0001293_anophthalmia	1.02878989
68	MP0002557_abnormal_social/conspecific_i	1.01705531
69	MP0005670_abnormal_white_adipose	1.00166002
70	MP0005499_abnormal_olfactory_system	0.99699162
71	MP0005394_taste/olfaction_phenotype	0.99699162
72	MP0009046_muscle_twitch	0.99634921
73	MP0002163_abnormal_gland_morphology	0.98344760
74	MP0003936_abnormal_reproductive_system	0.97148419
75	MP0010094_abnormal_chromosome_stability	0.96261301
76	MP0000631_abnormal_neuroendocrine_gland	0.92436467
77	MP0002277_abnormal_respiratory_mucosa	0.91941276
78	MP0003137_abnormal_impulse_conducting	0.91268271
79	MP0000026_abnormal_inner_ear	0.89829513
80	MP0001188_hyperpigmentation	0.89652918
81	MP0005379_endocrine/exocrine_gland_phen	0.89291160
82	MP0005253_abnormal_eye_physiology	0.89282277
83	MP0002572_abnormal_emotion/affect_behav	0.87370427
84	MP0008569_lethality_at_weaning	0.85708995
85	MP0001440_abnormal_grooming_behavior	0.85686271
86	MP0001905_abnormal_dopamine_level	0.84255447
87	MP0004133_heterotaxia	0.83898205
88	MP0003567_abnormal_fetal_cardiomyocyte	0.83417634
89	MP0002184_abnormal_innervation	0.83039268
90	MP0003011_delayed_dark_adaptation	0.80923390
91	MP0000685_abnormal_immune_system	0.80616914
92	MP0003787_abnormal_imprinting	0.80534319
93	MP0003937_abnormal_limbs/digits/tail_de	0.80431908
94	MP0001963_abnormal_hearing_physiology	0.80079502
95	MP0002210_abnormal_sex_determination	0.79790226
96	MP0003635_abnormal_synaptic_transmissio	0.79370984
97	MP0001119_abnormal_female_reproductive	0.79128575
98	MP0003122_maternal_imprinting	0.78974020
99	MP0006035_abnormal_mitochondrial_morpho	0.75644796
100	MP0002064_seizures	0.75577048

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.21057272
2	Acute encephalopathy (HP:0006846)	4.80328272
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.51526491
4	Progressive macrocephaly (HP:0004481)	4.31070867
5	3-Methylglutaconic aciduria (HP:0003535)	4.21064255
6	Mitochondrial inheritance (HP:0001427)	4.09034538
7	Colon cancer (HP:0003003)	4.08205171
8	Increased CSF lactate (HP:0002490)	3.96614128
9	Pancreatic cysts (HP:0001737)	3.75316475
10	Aplastic anemia (HP:0001915)	3.64499165
11	Increased hepatocellular lipid droplets (HP:0006565)	3.41230570
12	Pendular nystagmus (HP:0012043)	3.39488445
13	Reticulocytopenia (HP:0001896)	3.33026404
14	Lipid accumulation in hepatocytes (HP:0006561)	3.31235682
15	Hepatocellular necrosis (HP:0001404)	3.30999295
16	Focal motor seizures (HP:0011153)	3.17602970
17	Cerebral edema (HP:0002181)	3.11078128
18	Pancreatic fibrosis (HP:0100732)	3.07941138
19	Parakeratosis (HP:0001036)	3.06522839
20	Congenital stationary night blindness (HP:0007642)	2.94926293
21	Stomatitis (HP:0010280)	2.92278421
22	Optic disc pallor (HP:0000543)	2.89039275
23	Molar tooth sign on MRI (HP:0002419)	2.82993246
24	Abnormality of midbrain morphology (HP:0002418)	2.82993246
25	Hepatic necrosis (HP:0002605)	2.78990869
26	Increased serum lactate (HP:0002151)	2.74329963
27	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.56552980
28	Abnormality of alanine metabolism (HP:0010916)	2.56552980
29	Hyperalaninemia (HP:0003348)	2.56552980
30	Nephronophthisis (HP:0000090)	2.56111132
31	True hermaphroditism (HP:0010459)	2.56049019
32	Renal Fanconi syndrome (HP:0001994)	2.52566245
33	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.43578034
34	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.43404702
35	Agitation (HP:0000713)	2.40937193
36	Lactic acidosis (HP:0003128)	2.38355186
37	Leukodystrophy (HP:0002415)	2.35623239
38	Abnormality of the labia minora (HP:0012880)	2.34465808
39	Pancytopenia (HP:0001876)	2.33561841
40	Chromsome breakage (HP:0040012)	2.33513833
41	Increased intramyocellular lipid droplets (HP:0012240)	2.31863040
42	Respiratory failure (HP:0002878)	2.31844603
43	Hyperglycinemia (HP:0002154)	2.31139002
44	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.31091421
45	Abnormality of the anterior horn cell (HP:0006802)	2.29717698
46	Degeneration of anterior horn cells (HP:0002398)	2.29717698
47	Type II lissencephaly (HP:0007260)	2.26954842
48	Abnormality of the renal medulla (HP:0100957)	2.22509830
49	Exercise intolerance (HP:0003546)	2.21996991
50	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.21380288
51	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.21380288
52	Increased serum pyruvate (HP:0003542)	2.20113784
53	Abnormality of the renal cortex (HP:0011035)	2.12920591
54	Chorioretinal atrophy (HP:0000533)	2.12914455
55	Progressive inability to walk (HP:0002505)	2.09689706
56	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.07523496
57	IgG deficiency (HP:0004315)	2.07451933
58	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.07353908
59	Sclerocornea (HP:0000647)	2.06231386
60	Lethargy (HP:0001254)	2.03176042
61	Median cleft lip (HP:0000161)	2.02980789
62	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.02087939
63	Macrocytic anemia (HP:0001972)	2.00841384
64	Focal seizures (HP:0007359)	2.00743771
65	Congenital, generalized hypertrichosis (HP:0004540)	2.00584755
66	Abnormal biliary tract physiology (HP:0012439)	1.98963588
67	Bile duct proliferation (HP:0001408)	1.98963588
68	Cystic liver disease (HP:0006706)	1.98933396
69	Increased muscle lipid content (HP:0009058)	1.98091321
70	Horseshoe kidney (HP:0000085)	1.96748955
71	Medial flaring of the eyebrow (HP:0010747)	1.96525321
72	Supernumerary spleens (HP:0009799)	1.93643639
73	Methylmalonic acidemia (HP:0002912)	1.91269353
74	Synostosis of carpal bones (HP:0005048)	1.89378576
75	Exertional dyspnea (HP:0002875)	1.89216584
76	Amelogenesis imperfecta (HP:0000705)	1.86593818
77	Inability to walk (HP:0002540)	1.84459331
78	Absent thumb (HP:0009777)	1.84205947
79	Microvesicular hepatic steatosis (HP:0001414)	1.83694003
80	Rectal prolapse (HP:0002035)	1.83479189
81	Abnormality of cells of the erythroid lineage (HP:0012130)	1.82492156
82	Respiratory difficulties (HP:0002880)	1.81973058
83	Impulsivity (HP:0100710)	1.81797891
84	Postaxial foot polydactyly (HP:0001830)	1.80891236
85	Methylmalonic aciduria (HP:0012120)	1.80097993
86	Anencephaly (HP:0002323)	1.78350075
87	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.76983455
88	Delayed myelination (HP:0012448)	1.76807704
89	X-linked dominant inheritance (HP:0001423)	1.76554344
90	Abolished electroretinogram (ERG) (HP:0000550)	1.76216235
91	Abnormality of serum amino acid levels (HP:0003112)	1.75877867
92	Myokymia (HP:0002411)	1.75027480
93	Abnormal number of erythroid precursors (HP:0012131)	1.74804001
94	Chronic hepatic failure (HP:0100626)	1.73085589
95	Dialeptic seizures (HP:0011146)	1.71850417
96	Meckel diverticulum (HP:0002245)	1.71511221
97	Abnormality of glycolysis (HP:0004366)	1.69524726
98	Triphalangeal thumb (HP:0001199)	1.69061453
99	CNS demyelination (HP:0007305)	1.68895456
100	Hyperglycinuria (HP:0003108)	1.68195736

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	3.19467517
2	LATS1	3.18204636
3	STK38L	2.85967956
4	ZAK	2.83624879
5	NME1	2.70592745
6	TSSK6	2.66507216
7	ADRBK2	2.48699062
8	WNK3	2.40271421
9	EIF2AK3	2.29272873
10	VRK2	2.06188276
11	PDK2	2.04296177
12	STK16	1.97022054
13	WNK4	1.96446204
14	FRK	1.72947004
15	EIF2AK1	1.69812242
16	LATS2	1.65915321
17	DYRK3	1.65834082
18	GRK1	1.62196653
19	CSNK1A1L	1.61053216
20	DYRK2	1.60052032
21	SRPK1	1.57090871
22	TAF1	1.53595007
23	PRKD3	1.51504789
24	PLK3	1.41953307
25	EIF2AK2	1.35209351
26	NLK	1.34180313
27	NUAK1	1.32644810
28	NEK1	1.30764215
29	MAP4K2	1.27745617
30	CSNK1G2	1.25325637
31	VRK1	1.21778693
32	BCR	1.19722961
33	CSNK1G3	1.18808226
34	MST4	1.17922839
35	PINK1	1.12853897
36	PLK2	1.12593555
37	BMPR1B	1.07731526
38	NME2	1.07597207
39	MAP2K2	1.07071171
40	MKNK2	1.02205181
41	BUB1	1.00173999
42	PBK	0.99993901
43	IKBKE	0.99690874
44	ACVR1B	0.99022168
45	CSNK1G1	0.99001042
46	OXSR1	0.96998492
47	PIK3CA	0.96691159
48	MARK1	0.93254048
49	CASK	0.91987215
50	PLK1	0.91226135
51	TXK	0.88935383
52	PHKG2	0.87254390
53	PHKG1	0.87254390
54	PLK4	0.86076330
55	MAP3K4	0.85879961
56	ATR	0.84050507
57	CDK19	0.83465535
58	STK39	0.83262484
59	ADRBK1	0.80965338
60	STK3	0.79633470
61	MKNK1	0.74792578
62	PRKCG	0.73275300
63	MAP3K11	0.72514065
64	GRK7	0.72331533
65	TEC	0.69734767
66	INSRR	0.68205821
67	PAK4	0.66132634
68	ALK	0.65802193
69	RPS6KA4	0.65367073
70	MAPK13	0.65326454
71	PIK3CG	0.65092127
72	EPHA4	0.60862230
73	TNIK	0.59955565
74	CDC7	0.59938037
75	TIE1	0.59438085
76	CSNK2A2	0.59375109
77	CSNK1E	0.59070899
78	ITK	0.57557819
79	SIK3	0.57466543
80	GRK5	0.56602079
81	PAK3	0.55677316
82	CSNK1A1	0.54816052
83	MINK1	0.54095562
84	CSNK2A1	0.53283092
85	TLK1	0.51058010
86	RPS6KA5	0.50888059
87	CSNK1D	0.47699852
88	AURKB	0.46959494
89	STK10	0.46801644
90	PRKACA	0.46613883
91	LIMK1	0.43804966
92	PRKCI	0.42598163
93	MAPKAPK3	0.38082052
94	CAMK2A	0.37336390
95	DAPK1	0.37280851
96	MAP3K8	0.36502923
97	PRKCQ	0.36427118
98	BCKDK	0.35611550
99	NEK2	0.35186112
100	PRKCE	0.32887551

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.84268934
2	Ribosome_Homo sapiens_hsa03010	3.50441769
3	Parkinsons disease_Homo sapiens_hsa05012	3.11924182
4	Proteasome_Homo sapiens_hsa03050	3.09148769
5	RNA polymerase_Homo sapiens_hsa03020	3.07233333
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.06230914
7	Protein export_Homo sapiens_hsa03060	2.93735984
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.64500749
9	Basal transcription factors_Homo sapiens_hsa03022	2.52124921
10	Huntingtons disease_Homo sapiens_hsa05016	2.26375798
11	Alzheimers disease_Homo sapiens_hsa05010	2.10940655
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.10135252
13	Phototransduction_Homo sapiens_hsa04744	2.08878921
14	Asthma_Homo sapiens_hsa05310	2.07271105
15	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.97582960
16	Homologous recombination_Homo sapiens_hsa03440	1.92477565
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.86763418
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.81952894
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.76860809
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.65506719
21	Mismatch repair_Homo sapiens_hsa03430	1.60653656
22	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.49493968
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.46028572
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.45974953
25	One carbon pool by folate_Homo sapiens_hsa00670	1.39575743
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.37864426
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.36115598
28	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.34064727
29	Allograft rejection_Homo sapiens_hsa05330	1.32647568
30	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.32146972
31	RNA transport_Homo sapiens_hsa03013	1.31879629
32	RNA degradation_Homo sapiens_hsa03018	1.28959022
33	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.26769185
34	Propanoate metabolism_Homo sapiens_hsa00640	1.25542960
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.19200898
36	Spliceosome_Homo sapiens_hsa03040	1.17085217
37	Nucleotide excision repair_Homo sapiens_hsa03420	1.15544733
38	Steroid biosynthesis_Homo sapiens_hsa00100	1.15370193
39	Caffeine metabolism_Homo sapiens_hsa00232	1.10262319
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.10261216
41	Nicotine addiction_Homo sapiens_hsa05033	1.09949831
42	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.03839352
43	Butanoate metabolism_Homo sapiens_hsa00650	1.03314257
44	Purine metabolism_Homo sapiens_hsa00230	1.02396731
45	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.00339685
46	Pyruvate metabolism_Homo sapiens_hsa00620	0.95860746
47	Non-homologous end-joining_Homo sapiens_hsa03450	0.93727512
48	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.93087043
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.91827142
50	Peroxisome_Homo sapiens_hsa04146	0.91781019
51	Primary immunodeficiency_Homo sapiens_hsa05340	0.90840537
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.86190378
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.82307040
54	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.81573737
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.78973735
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78504257
57	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.75409070
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.73220732
59	Metabolic pathways_Homo sapiens_hsa01100	0.72828586
60	DNA replication_Homo sapiens_hsa03030	0.72329155
61	Arginine and proline metabolism_Homo sapiens_hsa00330	0.70209932
62	Taste transduction_Homo sapiens_hsa04742	0.69703919
63	Type I diabetes mellitus_Homo sapiens_hsa04940	0.65037835
64	Olfactory transduction_Homo sapiens_hsa04740	0.64903188
65	Folate biosynthesis_Homo sapiens_hsa00790	0.64573911
66	Sulfur metabolism_Homo sapiens_hsa00920	0.63051908
67	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.57498504
68	Morphine addiction_Homo sapiens_hsa05032	0.55535122
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.54283370
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.53648268
71	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.52685332
72	Retinol metabolism_Homo sapiens_hsa00830	0.51782786
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50973921
74	GABAergic synapse_Homo sapiens_hsa04727	0.48091544
75	Nitrogen metabolism_Homo sapiens_hsa00910	0.47893644
76	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.46682947
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.45821086
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.45229194
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.44108120
80	Ether lipid metabolism_Homo sapiens_hsa00565	0.44062606
81	Base excision repair_Homo sapiens_hsa03410	0.43774190
82	Serotonergic synapse_Homo sapiens_hsa04726	0.42875373
83	p53 signaling pathway_Homo sapiens_hsa04115	0.42691702
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42305298
85	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40913843
86	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.39032821
87	Graft-versus-host disease_Homo sapiens_hsa05332	0.38953019
88	Glutathione metabolism_Homo sapiens_hsa00480	0.33448273
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.32575253
90	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.29519369
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.28497187
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.24090115
93	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.22522706
94	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.22424550
95	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.19703004
96	Rheumatoid arthritis_Homo sapiens_hsa05323	0.18621111
97	Glutamatergic synapse_Homo sapiens_hsa04724	0.18467990
98	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.17856237
99	Histidine metabolism_Homo sapiens_hsa00340	0.15122490
100	Phenylalanine metabolism_Homo sapiens_hsa00360	0.14332037

HSPE1P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »