HSPE1P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)5.49892301
2protein neddylation (GO:0045116)5.18004443
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.91521581
4ATP synthesis coupled proton transport (GO:0015986)4.81698497
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.81698497
6proteasome assembly (GO:0043248)4.67937054
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.59911842
8DNA deamination (GO:0045006)4.55945028
9pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.42385787
10protein complex biogenesis (GO:0070271)4.39069322
11exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.34511927
12nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.24935376
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.09089303
14NADH dehydrogenase complex assembly (GO:0010257)4.09089303
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.09089303
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.06452482
17respiratory electron transport chain (GO:0022904)3.99224320
18electron transport chain (GO:0022900)3.95060394
19mitochondrial respiratory chain complex assembly (GO:0033108)3.94723497
20behavioral response to nicotine (GO:0035095)3.86221754
21GTP biosynthetic process (GO:0006183)3.82448431
22pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.80947380
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.75802982
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.75802982
25spliceosomal complex assembly (GO:0000245)3.74605755
26sequestering of actin monomers (GO:0042989)3.65459700
27DNA double-strand break processing (GO:0000729)3.61133024
28chaperone-mediated protein transport (GO:0072321)3.60053941
29rRNA modification (GO:0000154)3.55039794
30nonmotile primary cilium assembly (GO:0035058)3.47342964
31left/right axis specification (GO:0070986)3.40047907
32pyrimidine nucleotide catabolic process (GO:0006244)3.38302191
33histone mRNA metabolic process (GO:0008334)3.38245575
34regulation of mitochondrial translation (GO:0070129)3.34029820
35UTP biosynthetic process (GO:0006228)3.31717768
36cell wall macromolecule catabolic process (GO:0016998)3.31127052
37respiratory chain complex IV assembly (GO:0008535)3.28999211
38maturation of 5.8S rRNA (GO:0000460)3.22530380
39indolalkylamine metabolic process (GO:0006586)3.21793908
40epithelial cilium movement (GO:0003351)3.21790043
41rRNA methylation (GO:0031167)3.20863422
42base-excision repair, AP site formation (GO:0006285)3.20818556
43platelet dense granule organization (GO:0060155)3.20123028
44peptidyl-histidine modification (GO:0018202)3.20085359
45organelle disassembly (GO:1903008)3.19883451
46cytochrome complex assembly (GO:0017004)3.19263920
47somite development (GO:0061053)3.19110604
48substrate-independent telencephalic tangential migration (GO:0021826)3.19052352
49substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.19052352
50negative regulation of oligodendrocyte differentiation (GO:0048715)3.18374009
51ubiquinone metabolic process (GO:0006743)3.18125233
52termination of RNA polymerase III transcription (GO:0006386)3.14100499
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.14100499
54regulation of immunoglobulin secretion (GO:0051023)3.11641030
55ubiquinone biosynthetic process (GO:0006744)3.10524118
56spliceosomal snRNP assembly (GO:0000387)3.09908907
57cullin deneddylation (GO:0010388)3.09276391
58protein-cofactor linkage (GO:0018065)3.05826554
59purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.05542374
60purine nucleoside triphosphate biosynthetic process (GO:0009145)3.05473190
61chromatin remodeling at centromere (GO:0031055)3.04895168
62UTP metabolic process (GO:0046051)3.04033500
63preassembly of GPI anchor in ER membrane (GO:0016254)3.03353317
64protein targeting to mitochondrion (GO:0006626)2.99065106
65CENP-A containing nucleosome assembly (GO:0034080)2.98319893
66regulation of development, heterochronic (GO:0040034)2.98242298
67protein localization to mitochondrion (GO:0070585)2.97219287
68DNA damage response, detection of DNA damage (GO:0042769)2.95657943
69hydrogen ion transmembrane transport (GO:1902600)2.94828035
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.94377469
717-methylguanosine mRNA capping (GO:0006370)2.90340253
72pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.88176646
73positive regulation of mitochondrial fission (GO:0090141)2.86435016
74establishment of protein localization to mitochondrion (GO:0072655)2.85239411
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85009271
76pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.84837313
777-methylguanosine RNA capping (GO:0009452)2.84732310
78RNA capping (GO:0036260)2.84732310
79protein peptidyl-prolyl isomerization (GO:0000413)2.84702624
80anterograde synaptic vesicle transport (GO:0048490)2.82782813
81ATP biosynthetic process (GO:0006754)2.81256250
82negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.77489124
83CTP metabolic process (GO:0046036)2.77333335
84CTP biosynthetic process (GO:0006241)2.77333335
85mannosylation (GO:0097502)2.77143184
86proton transport (GO:0015992)2.76854396
87metallo-sulfur cluster assembly (GO:0031163)2.74668092
88iron-sulfur cluster assembly (GO:0016226)2.74668092
89regulation of timing of cell differentiation (GO:0048505)2.74614833
90cell wall macromolecule metabolic process (GO:0044036)2.73737619
91hydrogen transport (GO:0006818)2.73129653
92protein deneddylation (GO:0000338)2.72679969
93DNA catabolic process, exonucleolytic (GO:0000738)2.71114600
94DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.70982784
95ribonucleoside triphosphate biosynthetic process (GO:0009201)2.70095608
96tRNA processing (GO:0008033)2.69980194
97auditory behavior (GO:0031223)2.68604164
98regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.67598736
99regulation of mitotic spindle checkpoint (GO:1903504)2.67598736
100water-soluble vitamin biosynthetic process (GO:0042364)2.66138078

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.70079645
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.46757908
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.21071656
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.26158345
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.21407161
6ELK1_19687146_ChIP-ChIP_HELA_Human2.92023472
7VDR_23849224_ChIP-Seq_CD4+_Human2.76411142
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63909516
9ZNF274_21170338_ChIP-Seq_K562_Hela2.63674207
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48750821
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.46760868
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.42909176
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.40556026
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.38894349
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20319447
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16614579
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.12711130
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.07661315
19EZH2_22144423_ChIP-Seq_EOC_Human1.99642684
20EWS_26573619_Chip-Seq_HEK293_Human1.98240578
21MYC_18940864_ChIP-ChIP_HL60_Human1.93508245
22IGF1R_20145208_ChIP-Seq_DFB_Human1.93051764
23FOXP3_21729870_ChIP-Seq_TREG_Human1.88977376
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88644052
25VDR_22108803_ChIP-Seq_LS180_Human1.85627122
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80849272
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.76837867
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76446313
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.75254550
30IRF1_19129219_ChIP-ChIP_H3396_Human1.72661930
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69440309
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67677961
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67361496
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64934366
35GABP_19822575_ChIP-Seq_HepG2_Human1.63971876
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62590514
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60936973
38TP53_22573176_ChIP-Seq_HFKS_Human1.57268705
39DCP1A_22483619_ChIP-Seq_HELA_Human1.56602381
40TAF15_26573619_Chip-Seq_HEK293_Human1.56122385
41TTF2_22483619_ChIP-Seq_HELA_Human1.51435729
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50439578
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45780138
44P300_19829295_ChIP-Seq_ESCs_Human1.44856155
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42948482
46ELK1_22589737_ChIP-Seq_MCF10A_Human1.40082013
47FUS_26573619_Chip-Seq_HEK293_Human1.39925190
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38976240
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38953355
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38398973
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38224405
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34882873
53PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.32944065
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31885542
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28058982
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27591439
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.25289000
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24523524
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24024288
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23460997
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.23460997
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20854735
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20724968
64AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19486662
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18767591
66NANOG_19829295_ChIP-Seq_ESCs_Human1.17056802
67SOX2_19829295_ChIP-Seq_ESCs_Human1.17056802
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16619390
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.16160604
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13817919
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11872645
72ER_23166858_ChIP-Seq_MCF-7_Human1.11533336
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09279633
74AR_20517297_ChIP-Seq_VCAP_Human1.05966262
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04896250
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.04269817
77XRN2_22483619_ChIP-Seq_HELA_Human1.02384597
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02365670
79RNF2_27304074_Chip-Seq_NSC_Mouse1.02333807
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01447030
81CBP_20019798_ChIP-Seq_JUKART_Human1.01447030
82NCOR_22424771_ChIP-Seq_293T_Human0.98139029
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96514233
84TCF4_22108803_ChIP-Seq_LS180_Human0.95253881
85SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94896887
86THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94454879
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94109082
88NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93542895
89TAL1_26923725_Chip-Seq_HPCs_Mouse0.93478957
90E2F7_22180533_ChIP-Seq_HELA_Human0.89989596
91BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89969515
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89954965
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89406755
94CRX_20693478_ChIP-Seq_RETINA_Mouse0.89240792
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.86709900
96ERG_20517297_ChIP-Seq_VCAP_Human0.86500600
97TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85691572
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84196021
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.83310093
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83206647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.48740918
2MP0008877_abnormal_DNA_methylation2.95726979
3MP0002102_abnormal_ear_morphology2.91167414
4MP0005645_abnormal_hypothalamus_physiol2.89570293
5MP0005084_abnormal_gallbladder_morpholo2.83373602
6MP0006292_abnormal_olfactory_placode2.77022720
7MP0003787_abnormal_imprinting2.49836851
8MP0008789_abnormal_olfactory_epithelium2.43461881
9MP0008058_abnormal_DNA_repair2.31376534
10MP0008057_abnormal_DNA_replication2.23338188
11MP0004145_abnormal_muscle_electrophysio2.18739889
12MP0001529_abnormal_vocalization2.15824289
13MP0010094_abnormal_chromosome_stability2.14055038
14MP0005167_abnormal_blood-brain_barrier2.13829513
15MP0006072_abnormal_retinal_apoptosis2.08428689
16MP0005646_abnormal_pituitary_gland2.03606088
17MP0002837_dystrophic_cardiac_calcinosis1.97538062
18MP0003011_delayed_dark_adaptation1.91457977
19MP0003122_maternal_imprinting1.90403813
20MP0003880_abnormal_central_pattern1.87215683
21MP0002234_abnormal_pharynx_morphology1.77526393
22MP0006276_abnormal_autonomic_nervous1.70850639
23MP0002653_abnormal_ependyma_morphology1.70660261
24MP0005499_abnormal_olfactory_system1.70519188
25MP0005394_taste/olfaction_phenotype1.70519188
26MP0008995_early_reproductive_senescence1.65710084
27MP0003786_premature_aging1.61336150
28MP0002736_abnormal_nociception_after1.58446042
29MP0005253_abnormal_eye_physiology1.58225149
30MP0000372_irregular_coat_pigmentation1.55373107
31MP0005075_abnormal_melanosome_morpholog1.54162672
32MP0002928_abnormal_bile_duct1.54140065
33MP0005085_abnormal_gallbladder_physiolo1.54132230
34MP0005551_abnormal_eye_electrophysiolog1.53837353
35MP0004142_abnormal_muscle_tone1.49605632
36MP0003121_genomic_imprinting1.47741481
37MP0008872_abnormal_physiological_respon1.46934861
38MP0001984_abnormal_olfaction1.44720309
39MP0001293_anophthalmia1.43787586
40MP0000685_abnormal_immune_system1.42141331
41MP0000631_abnormal_neuroendocrine_gland1.38736231
42MP0009379_abnormal_foot_pigmentation1.38010687
43MP0003646_muscle_fatigue1.35013900
44MP0009046_muscle_twitch1.34176965
45MP0003718_maternal_effect1.33551174
46MP0002938_white_spotting1.29498330
47MP0003186_abnormal_redox_activity1.25006503
48MP0006036_abnormal_mitochondrial_physio1.22353382
49MP0002095_abnormal_skin_pigmentation1.19273082
50MP0009745_abnormal_behavioral_response1.19151765
51MP0005671_abnormal_response_to1.19089745
52MP0001968_abnormal_touch/_nociception1.17168745
53MP0001727_abnormal_embryo_implantation1.16082019
54MP0000049_abnormal_middle_ear1.13909133
55MP0002638_abnormal_pupillary_reflex1.13355100
56MP0003567_abnormal_fetal_cardiomyocyte1.11041160
57MP0003119_abnormal_digestive_system1.10380881
58MP0009697_abnormal_copulation1.10116194
59MP0005083_abnormal_biliary_tract1.07689599
60MP0002272_abnormal_nervous_system1.04404733
61MP0001835_abnormal_antigen_presentation1.01974337
62MP0004133_heterotaxia0.97640618
63MP0001879_abnormal_lymphatic_vessel0.94445816
64MP0008875_abnormal_xenobiotic_pharmacok0.90369178
65MP0005187_abnormal_penis_morphology0.89049640
66MP0002090_abnormal_vision0.88762637
67MP0002751_abnormal_autonomic_nervous0.87478615
68MP0005195_abnormal_posterior_eye0.87125539
69MP0001764_abnormal_homeostasis0.86205841
70MP0008007_abnormal_cellular_replicative0.85593799
71MP0001905_abnormal_dopamine_level0.84638772
72MP0001501_abnormal_sleep_pattern0.83517903
73MP0002160_abnormal_reproductive_system0.82722692
74MP0002210_abnormal_sex_determination0.82658373
75MP0005367_renal/urinary_system_phenotyp0.81925629
76MP0000516_abnormal_urinary_system0.81925629
77MP0005389_reproductive_system_phenotype0.81667045
78MP0005410_abnormal_fertilization0.80230254
79MP0001919_abnormal_reproductive_system0.77363937
80MP0008961_abnormal_basal_metabolism0.76439621
81MP0003077_abnormal_cell_cycle0.75745116
82MP0005408_hypopigmentation0.75533444
83MP0005391_vision/eye_phenotype0.75311106
84MP0002557_abnormal_social/conspecific_i0.74853842
85MP0001286_abnormal_eye_development0.74354857
86MP0003315_abnormal_perineum_morphology0.73933204
87MP0001270_distended_abdomen0.72870462
88MP0002572_abnormal_emotion/affect_behav0.72621657
89MP0004215_abnormal_myocardial_fiber0.71627039
90MP0008932_abnormal_embryonic_tissue0.69969311
91MP0000647_abnormal_sebaceous_gland0.69294397
92MP0000026_abnormal_inner_ear0.69042669
93MP0001188_hyperpigmentation0.67447122
94MP0003137_abnormal_impulse_conducting0.66586581
95MP0002752_abnormal_somatic_nervous0.65747958
96MP0002067_abnormal_sensory_capabilities0.64965926
97MP0005387_immune_system_phenotype0.64657602
98MP0001790_abnormal_immune_system0.64657602
99MP0005266_abnormal_metabolism0.64403254
100MP0001929_abnormal_gametogenesis0.63612594

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.45810708
2Acute encephalopathy (HP:0006846)4.69824323
3Mitochondrial inheritance (HP:0001427)4.68246771
4Abnormal mitochondria in muscle tissue (HP:0008316)4.68178591
5Progressive macrocephaly (HP:0004481)4.48725921
6Type II lissencephaly (HP:0007260)4.41139923
7Increased CSF lactate (HP:0002490)4.24768243
8Congenital, generalized hypertrichosis (HP:0004540)4.09677948
9Increased hepatocellular lipid droplets (HP:0006565)4.02100014
10Lipid accumulation in hepatocytes (HP:0006561)3.92473760
11Abnormality of midbrain morphology (HP:0002418)3.85702991
12Molar tooth sign on MRI (HP:0002419)3.85702991
13Pancreatic cysts (HP:0001737)3.59803787
14Pancreatic fibrosis (HP:0100732)3.49855617
15Hepatocellular necrosis (HP:0001404)3.38252446
16Cerebral edema (HP:0002181)3.31589039
17Retinal dysplasia (HP:0007973)3.08973509
18Renal Fanconi syndrome (HP:0001994)3.06495854
193-Methylglutaconic aciduria (HP:0003535)3.04640638
20Hepatic necrosis (HP:0002605)2.98761101
21True hermaphroditism (HP:0010459)2.94071991
22Leukodystrophy (HP:0002415)2.87029330
23Medial flaring of the eyebrow (HP:0010747)2.85949717
24Exertional dyspnea (HP:0002875)2.80762114
25Nephronophthisis (HP:0000090)2.78564135
26Delayed CNS myelination (HP:0002188)2.78509420
27Increased intramyocellular lipid droplets (HP:0012240)2.68064171
28Optic disc pallor (HP:0000543)2.65254815
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49330219
30Increased serum lactate (HP:0002151)2.47373949
31Abnormality of the renal medulla (HP:0100957)2.44570987
32Supernumerary spleens (HP:0009799)2.42793783
33Hyperglycinemia (HP:0002154)2.38625438
34Respiratory failure (HP:0002878)2.38591939
35Stomatitis (HP:0010280)2.34734450
36Lissencephaly (HP:0001339)2.32350127
37Increased muscle lipid content (HP:0009058)2.28945462
38Congenital primary aphakia (HP:0007707)2.27453516
39Lactic acidosis (HP:0003128)2.26807477
40Thyroid-stimulating hormone excess (HP:0002925)2.23763421
41Gait imbalance (HP:0002141)2.22880410
42IgG deficiency (HP:0004315)2.19248008
43Exercise intolerance (HP:0003546)2.18370951
44Abnormality of the renal cortex (HP:0011035)2.17584071
45Colon cancer (HP:0003003)2.14978643
46Cystic liver disease (HP:0006706)2.13792848
47Abnormality of the renal collecting system (HP:0004742)2.13238704
48Sclerocornea (HP:0000647)2.13062636
49Nephrogenic diabetes insipidus (HP:0009806)2.11851120
50Lethargy (HP:0001254)2.11207627
51Abnormality of the labia minora (HP:0012880)2.10046303
52Respiratory difficulties (HP:0002880)2.06904909
53Pendular nystagmus (HP:0012043)2.06220356
54Abnormal drinking behavior (HP:0030082)2.05113490
55Polydipsia (HP:0001959)2.05113490
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04594753
57Morphological abnormality of the pyramidal tract (HP:0002062)2.03962777
58Hemiparesis (HP:0001269)2.03350654
59Tubular atrophy (HP:0000092)2.02344356
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.02324453
61Abolished electroretinogram (ERG) (HP:0000550)1.99060880
62Dandy-Walker malformation (HP:0001305)1.98651932
63Abnormality of DNA repair (HP:0003254)1.97212656
64Duplicated collecting system (HP:0000081)1.95839523
65Aplasia/Hypoplasia of the uvula (HP:0010293)1.95276353
66Abnormality of renal resorption (HP:0011038)1.93013810
67X-linked dominant inheritance (HP:0001423)1.91365494
68Reticulocytopenia (HP:0001896)1.86605478
69Congenital stationary night blindness (HP:0007642)1.86201721
70Meckel diverticulum (HP:0002245)1.84682519
71Aplasia/hypoplasia of the uterus (HP:0008684)1.83537951
72Anencephaly (HP:0002323)1.82805608
73Congenital hepatic fibrosis (HP:0002612)1.82395367
74Postaxial foot polydactyly (HP:0001830)1.79732405
75Polyuria (HP:0000103)1.79486856
76Aplasia/Hypoplasia of the spleen (HP:0010451)1.78212269
77Abnormal rod and cone electroretinograms (HP:0008323)1.74760484
78Abnormality of the ileum (HP:0001549)1.73714284
79Inability to walk (HP:0002540)1.72839694
80Male pseudohermaphroditism (HP:0000037)1.71335163
81Broad-based gait (HP:0002136)1.70641601
82Type 2 muscle fiber atrophy (HP:0003554)1.70485814
83Absent rod-and cone-mediated responses on ERG (HP:0007688)1.68317728
84Abnormality of the anterior horn cell (HP:0006802)1.67485296
85Degeneration of anterior horn cells (HP:0002398)1.67485296
86Woolly hair (HP:0002224)1.67196530
87Postaxial hand polydactyly (HP:0001162)1.66606716
88Abnormal respiratory epithelium morphology (HP:0012253)1.65367071
89Abnormal respiratory motile cilium morphology (HP:0005938)1.65367071
90Increased serum pyruvate (HP:0003542)1.65009101
91Facial hemangioma (HP:0000329)1.64280272
92Cerebellar dysplasia (HP:0007033)1.63445396
93Abnormality of the vitreous humor (HP:0004327)1.62686412
94Median cleft lip (HP:0000161)1.62034668
95Abnormal biliary tract physiology (HP:0012439)1.61001472
96Bile duct proliferation (HP:0001408)1.61001472
97Aganglionic megacolon (HP:0002251)1.59766074
98Hypoplasia of the uterus (HP:0000013)1.58364720
99Aplastic anemia (HP:0001915)1.56604265
100Absent eyebrow (HP:0002223)1.54232144

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.96985928
2TIE13.50629772
3TXK2.95636527
4MAP4K22.84047480
5BCR2.62701535
6EIF2AK12.52696750
7VRK22.42418313
8CDK192.31166482
9SRPK12.29347224
10VRK12.10184994
11MST42.01628258
12MAPK151.98211894
13BCKDK1.88641707
14NUAK11.81565580
15EIF2AK31.78587022
16CSNK1G31.77212198
17WNK31.72157906
18MAPK131.69035376
19NME11.60744422
20CSNK1G21.60274291
21TRIM281.53636394
22CSNK1A1L1.52877389
23GRK11.50058536
24GRK71.48188202
25DYRK31.41225006
26CSNK1G11.40084145
27ZAK1.38275988
28OXSR11.37742603
29STK161.32833110
30ADRBK21.27359560
31EIF2AK21.22717203
32MAP3K41.21016117
33STK391.19039065
34MAP2K71.18445025
35TEC1.14243170
36TAF11.12849424
37PLK31.10804348
38SIK31.10001881
39DYRK21.06881424
40RPS6KA50.96376292
41WNK40.95189827
42GRK50.94314565
43WEE10.91395565
44PINK10.90716742
45BMPR20.90698122
46TAOK30.89699370
47MUSK0.88606494
48FRK0.86026714
49ERBB30.85677538
50BMPR1B0.85581241
51BUB10.85140340
52DAPK20.79223960
53UHMK10.79222587
54ATR0.77645436
55EPHA40.77124405
56CCNB10.76003043
57PLK40.72588581
58EPHB20.72105827
59RPS6KA40.69334068
60CDC70.68528423
61INSRR0.66975304
62NTRK20.65670458
63PLK10.65621782
64NEK10.64357013
65PLK20.63246260
66MOS0.62661806
67PNCK0.60760734
68AURKB0.59934345
69MKNK10.59367847
70CSNK2A10.59320002
71DAPK30.56618775
72AURKA0.56161797
73DAPK10.53281612
74PRKCG0.52933545
75TLK10.51908698
76PIK3CA0.51250921
77CHEK20.50878191
78CSNK1A10.48554455
79TNIK0.47260765
80ITK0.46485479
81CSNK2A20.46341047
82MAPKAPK50.45190058
83CAMK2A0.44005023
84MINK10.41679217
85SIK20.41657171
86CDK80.41019302
87STK100.40219262
88CAMK40.37740349
89KDR0.37054691
90PRKACA0.35608952
91PRKCE0.34625090
92ADRBK10.33821703
93NEK90.33330528
94PKN10.33281335
95PAK30.31714516
96OBSCN0.30785858
97BTK0.30613901
98PRKCQ0.30325347
99PDK20.30267004
100LYN0.30224802

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.96756903
2Protein export_Homo sapiens_hsa030603.89929374
3Proteasome_Homo sapiens_hsa030503.63443366
4Parkinsons disease_Homo sapiens_hsa050123.24036434
5Ribosome_Homo sapiens_hsa030102.72798533
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42020134
7RNA polymerase_Homo sapiens_hsa030202.40500646
8Mismatch repair_Homo sapiens_hsa034302.34219880
9Homologous recombination_Homo sapiens_hsa034402.30363329
10Huntingtons disease_Homo sapiens_hsa050162.22634512
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21186205
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.19018707
13Alzheimers disease_Homo sapiens_hsa050102.15579943
14DNA replication_Homo sapiens_hsa030302.02687749
15RNA degradation_Homo sapiens_hsa030182.00778881
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98553256
17Spliceosome_Homo sapiens_hsa030401.97271703
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94311878
19Nucleotide excision repair_Homo sapiens_hsa034201.93661954
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.80095795
21Basal transcription factors_Homo sapiens_hsa030221.77003287
22Fanconi anemia pathway_Homo sapiens_hsa034601.75367165
23Phototransduction_Homo sapiens_hsa047441.67710733
24Asthma_Homo sapiens_hsa053101.63073571
25Pyrimidine metabolism_Homo sapiens_hsa002401.59443771
26Propanoate metabolism_Homo sapiens_hsa006401.46269915
27Butanoate metabolism_Homo sapiens_hsa006501.39790418
28Cardiac muscle contraction_Homo sapiens_hsa042601.39095742
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.37315168
30One carbon pool by folate_Homo sapiens_hsa006701.24442876
31Systemic lupus erythematosus_Homo sapiens_hsa053221.22346598
32Steroid biosynthesis_Homo sapiens_hsa001001.21233028
33RNA transport_Homo sapiens_hsa030131.16389197
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14477967
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11996252
36Tryptophan metabolism_Homo sapiens_hsa003801.11513961
37Base excision repair_Homo sapiens_hsa034101.10148808
38Primary immunodeficiency_Homo sapiens_hsa053401.05853519
39Allograft rejection_Homo sapiens_hsa053301.03648750
40Autoimmune thyroid disease_Homo sapiens_hsa053200.98786441
41Purine metabolism_Homo sapiens_hsa002300.97244315
42Nitrogen metabolism_Homo sapiens_hsa009100.96887361
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93382323
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93224709
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89261357
46Peroxisome_Homo sapiens_hsa041460.89136565
47Type I diabetes mellitus_Homo sapiens_hsa049400.88767580
48Linoleic acid metabolism_Homo sapiens_hsa005910.85948033
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83132557
50Antigen processing and presentation_Homo sapiens_hsa046120.81442482
51Nicotine addiction_Homo sapiens_hsa050330.81297717
52Alcoholism_Homo sapiens_hsa050340.78403151
53Olfactory transduction_Homo sapiens_hsa047400.77573230
54Folate biosynthesis_Homo sapiens_hsa007900.75005476
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74089670
56Sulfur metabolism_Homo sapiens_hsa009200.72059072
57Rheumatoid arthritis_Homo sapiens_hsa053230.70519109
58Graft-versus-host disease_Homo sapiens_hsa053320.67747604
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.67423316
60Metabolic pathways_Homo sapiens_hsa011000.67167542
61Collecting duct acid secretion_Homo sapiens_hsa049660.62908840
62beta-Alanine metabolism_Homo sapiens_hsa004100.60753092
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58672217
64Vitamin B6 metabolism_Homo sapiens_hsa007500.58538405
65Pyruvate metabolism_Homo sapiens_hsa006200.58380461
66GABAergic synapse_Homo sapiens_hsa047270.53498245
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53027983
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.51383581
69Retinol metabolism_Homo sapiens_hsa008300.49830827
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49694830
71Ether lipid metabolism_Homo sapiens_hsa005650.49211918
72Epstein-Barr virus infection_Homo sapiens_hsa051690.48730938
73Chemical carcinogenesis_Homo sapiens_hsa052040.48425767
74Caffeine metabolism_Homo sapiens_hsa002320.48053456
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44835387
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44561017
77Taste transduction_Homo sapiens_hsa047420.44513459
78Sulfur relay system_Homo sapiens_hsa041220.43719109
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.42617549
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38956892
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38328161
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38295603
83mRNA surveillance pathway_Homo sapiens_hsa030150.37724900
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37544732
85Morphine addiction_Homo sapiens_hsa050320.37382976
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36788515
87Hematopoietic cell lineage_Homo sapiens_hsa046400.35543557
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34260561
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32479863
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29127084
91Fatty acid metabolism_Homo sapiens_hsa012120.28313536
92Cell cycle_Homo sapiens_hsa041100.28008753
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27693325
94Arginine and proline metabolism_Homo sapiens_hsa003300.27194457
95Arachidonic acid metabolism_Homo sapiens_hsa005900.25541170
96Fatty acid degradation_Homo sapiens_hsa000710.25480011
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25039247
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24891395
99p53 signaling pathway_Homo sapiens_hsa041150.23611290
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22965322

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