HSPG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)6.73560335
2basement membrane organization (GO:0071711)6.07450209
3plasma membrane repair (GO:0001778)5.93410652
4protein heterotrimerization (GO:0070208)4.96487841
5retina vasculature morphogenesis in camera-type eye (GO:0061299)4.83489899
6branching involved in salivary gland morphogenesis (GO:0060445)4.83413309
7cardiac myofibril assembly (GO:0055003)4.57388230
8vascular endothelial growth factor signaling pathway (GO:0038084)4.48154763
9collagen fibril organization (GO:0030199)4.36516786
10sequestering of extracellular ligand from receptor (GO:0035581)4.36190852
11endodermal cell differentiation (GO:0035987)4.30887650
12cell-substrate junction assembly (GO:0007044)4.23795043
13adherens junction assembly (GO:0034333)4.19710980
14substrate-dependent cell migration (GO:0006929)4.04314832
15focal adhesion assembly (GO:0048041)3.96800427
16cell-substrate adherens junction assembly (GO:0007045)3.96800427
17bone trabecula formation (GO:0060346)3.92681375
18polarized epithelial cell differentiation (GO:0030859)3.91708746
19epithelial cell-cell adhesion (GO:0090136)3.82901228
20cell migration involved in sprouting angiogenesis (GO:0002042)3.82624435
21negative regulation of blood vessel endothelial cell migration (GO:0043537)3.80353848
22sarcomere organization (GO:0045214)3.79679137
23renal filtration (GO:0097205)3.78302383
24hippo signaling (GO:0035329)3.73873230
25regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.72537675
26glomerular filtration (GO:0003094)3.69129309
27sprouting angiogenesis (GO:0002040)3.64585299
28axon extension involved in axon guidance (GO:0048846)3.64505432
29neuron projection extension involved in neuron projection guidance (GO:1902284)3.64505432
30positive regulation of blood vessel endothelial cell migration (GO:0043536)3.64423987
31regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.63854085
32lymphangiogenesis (GO:0001946)3.62448709
33myofibril assembly (GO:0030239)3.60494770
34paraxial mesoderm development (GO:0048339)3.60138041
35hemidesmosome assembly (GO:0031581)3.58560009
36collagen metabolic process (GO:0032963)3.57575889
37cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.56994702
38chondrocyte proliferation (GO:0035988)3.56264139
39substrate adhesion-dependent cell spreading (GO:0034446)3.55202171
40endothelial cell morphogenesis (GO:0001886)3.53099836
41skin morphogenesis (GO:0043589)3.51843416
42endothelial tube morphogenesis (GO:0061154)3.51440826
43morphogenesis of an endothelium (GO:0003159)3.51440826
44blood vessel endothelial cell migration (GO:0043534)3.48276331
45collagen catabolic process (GO:0030574)3.46854117
46* extracellular matrix disassembly (GO:0022617)3.41605461
47negative regulation of adherens junction organization (GO:1903392)3.41265085
48negative regulation of focal adhesion assembly (GO:0051895)3.41265085
49negative regulation of cell junction assembly (GO:1901889)3.41265085
50heart trabecula formation (GO:0060347)3.41225658
51venous blood vessel morphogenesis (GO:0048845)3.40098842
52trabecula formation (GO:0060343)3.39497306
53multicellular organismal macromolecule metabolic process (GO:0044259)3.38449652
54positive regulation of receptor recycling (GO:0001921)3.37930978
55bundle of His cell to Purkinje myocyte communication (GO:0086069)3.37712567
56angiogenesis involved in wound healing (GO:0060055)3.37530650
57insulin-like growth factor receptor signaling pathway (GO:0048009)3.36732082
58dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.36216421
59endothelial cell chemotaxis (GO:0035767)3.33061899
60blood vessel maturation (GO:0001955)3.32704528
61glomerular basement membrane development (GO:0032836)3.29662485
62regulation of blood vessel endothelial cell migration (GO:0043535)3.28508946
63wound healing, spreading of cells (GO:0044319)3.26297366
64negative regulation of chondrocyte differentiation (GO:0032331)3.22419587
65lymph vessel development (GO:0001945)3.21814659
66extracellular matrix assembly (GO:0085029)3.21474803
67regulation of tight junction assembly (GO:2000810)3.21075463
68multicellular organismal catabolic process (GO:0044243)3.19375443
69multicellular organismal metabolic process (GO:0044236)3.18288440
70positive regulation of endothelial cell migration (GO:0010595)3.17618318
71wound healing, spreading of epidermal cells (GO:0035313)3.15043361
72artery development (GO:0060840)3.10752714
73cell adhesion mediated by integrin (GO:0033627)3.10042661
74positive regulation of chondrocyte differentiation (GO:0032332)3.09034946
75cytoskeletal anchoring at plasma membrane (GO:0007016)3.07190271
76negative regulation of endothelial cell migration (GO:0010596)3.06132415
77patterning of blood vessels (GO:0001569)3.04533828
78semaphorin-plexin signaling pathway (GO:0071526)3.02722105
79regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.02360076
80actomyosin structure organization (GO:0031032)3.02173973
81heart morphogenesis (GO:0003007)3.01276997
82positive regulation of cartilage development (GO:0061036)3.00146535
83regulation of cardioblast differentiation (GO:0051890)2.99058414
84positive regulation of endothelial cell differentiation (GO:0045603)2.96660691
85regulation of chondrocyte differentiation (GO:0032330)2.95252833
86muscle filament sliding (GO:0030049)2.95208502
87actin-myosin filament sliding (GO:0033275)2.95208502
88endocardial cushion development (GO:0003197)2.94317978
89establishment of apical/basal cell polarity (GO:0035089)2.93466797
90neuron remodeling (GO:0016322)2.92454395
91regulation of hippo signaling (GO:0035330)2.91801946
92stress fiber assembly (GO:0043149)2.91510893
93positive regulation of endothelial cell apoptotic process (GO:2000353)2.90618092
94positive regulation of osteoblast proliferation (GO:0033690)2.89016854
95regulation of transforming growth factor beta1 production (GO:0032908)2.88222325
96cardiac muscle cell development (GO:0055013)2.87330064
97protein localization to endosome (GO:0036010)2.86914840
98regulation of endothelial cell differentiation (GO:0045601)2.86361578
99regulation of glomerular filtration (GO:0003093)2.85401654
100negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.85305280
101negative regulation of cartilage development (GO:0061037)2.84962430
102negative regulation of fatty acid transport (GO:2000192)2.84228722
103adherens junction organization (GO:0034332)2.83471716
104hyaluronan catabolic process (GO:0030214)2.83231268
105apoptotic cell clearance (GO:0043277)2.82790754
106regulation of endothelial cell migration (GO:0010594)2.82702208
107endothelial cell migration (GO:0043542)2.82407422
108negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.81154717
109mRNA transcription (GO:0009299)2.80107905
110cardiac cell development (GO:0055006)2.78299509
111regulation of cartilage development (GO:0061035)2.78024816
112vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.77495458
113regulation of plasminogen activation (GO:0010755)2.74816759
114atrioventricular valve morphogenesis (GO:0003181)2.74217242
115regulation of SMAD protein import into nucleus (GO:0060390)2.74198860
116endothelial cell proliferation (GO:0001935)2.73961550
117cell migration involved in heart development (GO:0060973)2.73561138
118positive regulation of epithelial cell migration (GO:0010634)2.70896842
119smooth muscle tissue development (GO:0048745)2.70719116
120positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.67682584
121positive regulation of glycogen biosynthetic process (GO:0045725)2.67302071
122regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.65182070
123negative regulation of cell size (GO:0045792)2.64745977
124vasculogenesis (GO:0001570)2.64216227
125positive regulation of collagen biosynthetic process (GO:0032967)2.63584393
126cardiac muscle cell proliferation (GO:0060038)2.62640910
127planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61311814
128ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.59588831
129extracellular fibril organization (GO:0043206)2.58753464
130regulation of gonadotropin secretion (GO:0032276)2.58559916
131actin-mediated cell contraction (GO:0070252)2.58237193
132regulation of p38MAPK cascade (GO:1900744)2.57976445
133negative regulation of smooth muscle cell migration (GO:0014912)2.56741652
134negative regulation of potassium ion transmembrane transport (GO:1901380)2.55884157
135negative regulation of heart growth (GO:0061117)2.55863452
136negative regulation of cardiac muscle tissue growth (GO:0055022)2.55863452
137cell-substrate adhesion (GO:0031589)2.55834333
138endothelial cell differentiation (GO:0045446)2.55693103
139* extracellular matrix organization (GO:0030198)2.54936213
140fibroblast migration (GO:0010761)2.54719476
141* extracellular structure organization (GO:0043062)2.54111982
142apoptotic process involved in morphogenesis (GO:0060561)2.53928063
143regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.52377043

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.88015298
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.26009557
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.72803140
4ZNF263_19887448_ChIP-Seq_K562_Human3.44285205
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.21260315
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.16891926
7CLOCK_20551151_ChIP-Seq_293T_Human3.03126006
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.60050953
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.59216990
10* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.56015777
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.51399736
12* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.50500576
13* ELK3_25401928_ChIP-Seq_HUVEC_Human2.47987792
14* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.35651012
15HIF1A_21447827_ChIP-Seq_MCF-7_Human2.17394089
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10905487
17TBX20_22080862_ChIP-Seq_HEART_Mouse2.08291220
18TBX20_22328084_ChIP-Seq_HEART_Mouse2.08291220
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06320981
20* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.05640843
21ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.01695663
22* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96233230
23WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.95684751
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.90405721
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.84583104
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.79332921
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.78564768
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.76548193
29* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73719915
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71754473
31KDM2B_26808549_Chip-Seq_DND41_Human1.70280577
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.69271562
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68804000
34* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.68684779
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65663389
36* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.63770806
37CJUN_26792858_Chip-Seq_BT549_Human1.62545520
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58550821
39* KDM2B_26808549_Chip-Seq_K562_Human1.57621006
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57064198
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55814427
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.55500206
43* BRD4_25478319_ChIP-Seq_HGPS_Human1.55219299
44* RACK7_27058665_Chip-Seq_MCF-7_Human1.54554983
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53733457
46SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50752634
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.48982404
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47643257
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47643257
50MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.46182756
51ISL1_27105846_Chip-Seq_CPCs_Mouse1.45709896
52* ATF3_27146783_Chip-Seq_COLON_Human1.44073406
53* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.42407068
54HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41396669
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41369574
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.41008903
57* GATA2_21666600_ChIP-Seq_HMVEC_Human1.40376810
58SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.40209781
59SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.40209781
60SALL4_18804426_ChIP-ChIP_XEN_Mouse1.38804899
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.38486424
62TP53_22127205_ChIP-Seq_IMR90_Human1.37051523
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.35683230
64UBF1/2_26484160_Chip-Seq_HMECs_Human1.34631465
65* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34000788
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32871689
67LXR_22292898_ChIP-Seq_THP-1_Human1.32247180
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31511114
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29982817
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29509262
71TCF3_18692474_ChIP-Seq_MEFs_Mouse1.28714483
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27885156
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27314681
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27242077
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.26282013
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.25587798
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24704604
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22485935
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21467093
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21467093
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21467093
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.21205411
83* TP53_23651856_ChIP-Seq_MEFs_Mouse1.19701853
84* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19348346
85FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.17387380
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.17326779
87SMC1_22415368_ChIP-Seq_MEFs_Mouse1.16118875
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15728433
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.15627692
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14105936
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14072472
92TP53_16413492_ChIP-PET_HCT116_Human1.13884789
93* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12834802
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12541938
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12536237
96RUNX1_27514584_Chip-Seq_MCF-7_Human1.12035216
97EED_16625203_ChIP-ChIP_MESCs_Mouse1.11502307
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11074642
99TCF7_22412390_ChIP-Seq_EML_Mouse1.10614898
100* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10329585
101* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09515132
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08648252
103MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08248029
104TET1_21490601_ChIP-Seq_MESCs_Mouse1.06841420
105* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06403494
106JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04930716
107PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04838959
108* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04198087
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03614468
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02592279
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01663700
112SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00845043
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99266539
114SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97994167
115* KLF5_25053715_ChIP-Seq_YYC3_Human0.97545422
116JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95615509
117CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94810353
118TCF4_18268006_ChIP-ChIP_LS174T_Human0.94306396
119SA1_22415368_ChIP-Seq_MEFs_Mouse0.94298989
120RNF2_27304074_Chip-Seq_ESCs_Mouse0.92671639
121DROSHA_22980978_ChIP-Seq_HELA_Human0.92268224
122* GATA1_19941826_ChIP-Seq_K562_Human0.90419976
123SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90330955
124* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89037546
125CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88700688

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.93661574
2* MP0004272_abnormal_basement_membrane4.50621464
3MP0003705_abnormal_hypodermis_morpholog4.42263738
4MP0005275_abnormal_skin_tensile3.94435588
5MP0010368_abnormal_lymphatic_system3.58596606
6MP0005503_abnormal_tendon_morphology3.14424946
7MP0005623_abnormal_meninges_morphology3.12195408
8MP0000751_myopathy2.95383059
9* MP0003279_aneurysm2.80847582
10MP0004084_abnormal_cardiac_muscle2.72774027
11MP0001958_emphysema2.34979168
12MP0002837_dystrophic_cardiac_calcinosis2.20628144
13MP0003566_abnormal_cell_adhesion2.17727108
14MP0000750_abnormal_muscle_regeneration2.11769445
15MP0001879_abnormal_lymphatic_vessel2.09454118
16MP0003941_abnormal_skin_development1.97528995
17MP0005409_darkened_coat_color1.94468051
18MP0005330_cardiomyopathy1.81377613
19MP0003828_pulmonary_edema1.74995964
20MP0006054_spinal_hemorrhage1.73381267
21MP0005595_abnormal_vascular_smooth1.72937858
22MP0000749_muscle_degeneration1.72619174
23* MP0004087_abnormal_muscle_fiber1.71689012
24MP0000733_abnormal_muscle_development1.68261474
25MP0006138_congestive_heart_failure1.63251759
26MP0010030_abnormal_orbit_morphology1.58588025
27MP0010630_abnormal_cardiac_muscle1.57487800
28MP0000767_abnormal_smooth_muscle1.54820784
29MP0010352_gastrointestinal_tract_polyps1.53896596
30MP0004215_abnormal_myocardial_fiber1.53833506
31MP0004036_abnormal_muscle_relaxation1.53723557
32MP0003091_abnormal_cell_migration1.48714938
33MP0004858_abnormal_nervous_system1.39749130
34* MP0002108_abnormal_muscle_morphology1.39295670
35MP0002060_abnormal_skin_morphology1.38097216
36MP0003385_abnormal_body_wall1.38049419
37MP0000013_abnormal_adipose_tissue1.37436582
38MP0003115_abnormal_respiratory_system1.31064552
39MP0000465_gastrointestinal_hemorrhage1.29415333
40MP0005076_abnormal_cell_differentiation1.28449413
41* MP0000759_abnormal_skeletal_muscle1.28070976
42MP0003950_abnormal_plasma_membrane1.26940615
43MP0005023_abnormal_wound_healing1.25443856
44MP0008775_abnormal_heart_ventricle1.24821368
45MP0001544_abnormal_cardiovascular_syste1.24750706
46MP0005385_cardiovascular_system_phenoty1.24750706
47MP0002972_abnormal_cardiac_muscle1.23819424
48* MP0005508_abnormal_skeleton_morphology1.23242115
49MP0002295_abnormal_pulmonary_circulatio1.19383378
50MP0009384_cardiac_valve_regurgitation1.17843341
51MP0003283_abnormal_digestive_organ1.16271488
52MP0003045_fibrosis1.16017125
53* MP0002128_abnormal_blood_circulation1.15771205
54MP0000003_abnormal_adipose_tissue1.14792791
55MP0001243_abnormal_dermal_layer1.14739245
56* MP0002925_abnormal_cardiovascular_devel1.13640213
57* MP0002106_abnormal_muscle_physiology1.11626016
58MP0004185_abnormal_adipocyte_glucose1.11104259
59MP0002269_muscular_atrophy1.10624182
60MP0005620_abnormal_muscle_contractility1.10535770
61MP0004233_abnormal_muscle_weight1.09166660
62* MP0001614_abnormal_blood_vessel1.08829323
63* MP0005369_muscle_phenotype1.08687803
64MP0005670_abnormal_white_adipose1.08063590
65MP0003122_maternal_imprinting1.08024014
66MP0003942_abnormal_urinary_system1.07994186
67MP0005375_adipose_tissue_phenotype1.06666272
68MP0000467_abnormal_esophagus_morphology1.05431666
69MP0000249_abnormal_blood_vessel1.05155660
70MP0008004_abnormal_stomach_pH1.04830761
71MP0000747_muscle_weakness1.04262525
72MP0001915_intracranial_hemorrhage1.04247038
73MP0005666_abnormal_adipose_tissue1.04052446
74MP0005171_absent_coat_pigmentation1.03696696
75* MP0000266_abnormal_heart_morphology1.02898820
76MP0003567_abnormal_fetal_cardiomyocyte1.01977794
77MP0001348_abnormal_lacrimal_gland1.00728359
78MP0000534_abnormal_ureter_morphology0.99747883
79MP0009780_abnormal_chondrocyte_physiolo0.99740780
80MP0004197_abnormal_fetal_growth/weight/0.98937986
81MP0009053_abnormal_anal_canal0.98638556
82MP0005257_abnormal_intraocular_pressure0.98580160
83MP0003935_abnormal_craniofacial_develop0.98462068
84* MP0002896_abnormal_bone_mineralization0.97980841
85MP0000537_abnormal_urethra_morphology0.97734143
86MP0001661_extended_life_span0.96747707
87MP0005165_increased_susceptibility_to0.94863546
88MP0000462_abnormal_digestive_system0.94296887
89MP0002282_abnormal_trachea_morphology0.93963731
90* MP0002933_joint_inflammation0.92300241
91MP0004134_abnormal_chest_morphology0.91042434
92MP0004130_abnormal_muscle_cell0.89436818
93MP0002168_other_aberrant_phenotype0.88672162
94MP0002138_abnormal_hepatobiliary_system0.87325074
95MP0004133_heterotaxia0.85046778
96MP0004782_abnormal_surfactant_physiolog0.84810527
97MP0000762_abnormal_tongue_morphology0.84412943
98MP0005167_abnormal_blood-brain_barrier0.83733327
99MP0003300_gastrointestinal_ulcer0.83330915
100MP0002088_abnormal_embryonic_growth/wei0.81601610
101MP0003984_embryonic_growth_retardation0.81499106
102* MP0009250_abnormal_appendicular_skeleto0.78337395
103MP0002877_abnormal_melanocyte_morpholog0.77621844
104MP0002086_abnormal_extraembryonic_tissu0.77447141
105MP0002092_abnormal_eye_morphology0.77300944
106MP0005197_abnormal_uvea_morphology0.76427042
107* MP0002932_abnormal_joint_morphology0.76305985
108MP0001849_ear_inflammation0.76127488
109* MP0000428_abnormal_craniofacial_morphol0.75785295
110MP0000678_abnormal_parathyroid_gland0.75118801
111MP0009278_abnormal_bone_marrow0.75004814
112MP0002127_abnormal_cardiovascular_syste0.74218392
113* MP0002697_abnormal_eye_size0.73382923
114MP0003303_peritoneal_inflammation0.72120691
115MP0002796_impaired_skin_barrier0.72103993
116MP0003137_abnormal_impulse_conducting0.71779411
117MP0001299_abnormal_eye_distance/0.71704029
118MP0004484_altered_response_of0.69426228
119MP0002998_abnormal_bone_remodeling0.68727742
120MP0005380_embryogenesis_phenotype0.68119681
121MP0001672_abnormal_embryogenesis/_devel0.68119681
122MP0001175_abnormal_lung_morphology0.67890475
123MP0005164_abnormal_response_to0.67218460
124* MP0004085_abnormal_heartbeat0.67163968
125MP0002332_abnormal_exercise_endurance0.66919430
126MP0002133_abnormal_respiratory_system0.65524882
127MP0005388_respiratory_system_phenotype0.65524882
128MP0001542_abnormal_bone_strength0.65045975
129* MP0001784_abnormal_fluid_regulation0.64506936
130MP0003868_abnormal_feces_composition0.64098653
131* MP0005390_skeleton_phenotype0.62573437

Predicted human phenotypes

RankGene SetZ-score
1* Protrusio acetabuli (HP:0003179)6.61926326
2Premature rupture of membranes (HP:0001788)5.74021895
3Cerebral aneurysm (HP:0004944)5.51815920
4Increased connective tissue (HP:0009025)4.89067664
5Ankle contracture (HP:0006466)4.68485394
6Shallow orbits (HP:0000586)4.61409588
7Broad metatarsal (HP:0001783)4.58506986
8Muscle fiber splitting (HP:0003555)4.23952447
9Vascular tortuosity (HP:0004948)4.02614977
10Arterial tortuosity (HP:0005116)4.01881370
11Aortic dissection (HP:0002647)4.00919904
12Type 1 muscle fiber predominance (HP:0003803)3.84012979
13Atrophic scars (HP:0001075)3.70533757
14Fragile skin (HP:0001030)3.39347341
15Mitral valve prolapse (HP:0001634)3.30823674
16Increased variability in muscle fiber diameter (HP:0003557)3.30270004
17Bladder diverticulum (HP:0000015)3.24906303
18Aortic aneurysm (HP:0004942)3.19766456
19Difficulty climbing stairs (HP:0003551)3.14197416
20Hyporeflexia of lower limbs (HP:0002600)3.12951654
21Dilatation of the ascending aorta (HP:0005111)3.08574648
22Esophageal varix (HP:0002040)3.04928788
23Right ventricular cardiomyopathy (HP:0011663)3.02095328
24Soft skin (HP:0000977)3.01256638
25Mildly elevated creatine phosphokinase (HP:0008180)3.01112494
26Genu recurvatum (HP:0002816)3.00485658
27Aneurysm (HP:0002617)2.96770215
28Abnormality of skeletal muscle fiber size (HP:0012084)2.95031698
29Peritonitis (HP:0002586)2.90389699
30Ventricular tachycardia (HP:0004756)2.89510586
31Round ear (HP:0100830)2.87965069
32Broad face (HP:0000283)2.87774748
33Ulnar bowing (HP:0003031)2.85167107
34Sudden death (HP:0001699)2.85106858
35* Spinal rigidity (HP:0003306)2.85070813
36Difficulty running (HP:0009046)2.84254262
37Spontaneous hematomas (HP:0007420)2.79130565
38Hematochezia (HP:0002573)2.77501778
39Short 4th metacarpal (HP:0010044)2.75374824
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.75374824
41Polycythemia (HP:0001901)2.71061863
42Thin bony cortex (HP:0002753)2.68515887
43Lipoatrophy (HP:0100578)2.60068169
44Follicular hyperkeratosis (HP:0007502)2.60022374
45Lymphangioma (HP:0100764)2.59232924
46Aortic valve stenosis (HP:0001650)2.58127372
47Radial bowing (HP:0002986)2.56621721
48Cervical subluxation (HP:0003308)2.54092576
49Slender build (HP:0001533)2.46343045
50Abnormality of the calf musculature (HP:0001430)2.44210306
51Short nail (HP:0001799)2.40084416
52Abnormality of the 4th metacarpal (HP:0010012)2.35694135
53Aortic regurgitation (HP:0001659)2.35201290
54Abnormality of dentin (HP:0010299)2.34420661
55Hemorrhage of the eye (HP:0011885)2.32923095
56Neonatal short-limb short stature (HP:0008921)2.28466088
57Hypoplasia of the iris (HP:0007676)2.27736600
58Distal lower limb muscle weakness (HP:0009053)2.23150403
59* Blue sclerae (HP:0000592)2.23072426
60Joint stiffness (HP:0001387)2.21972691
61Camptodactyly of toe (HP:0001836)2.20149755
62Abnormality of the distal phalanx of the thumb (HP:0009617)2.19480045
63Hyperextensible skin (HP:0000974)2.15623274
64Hypoplastic ischia (HP:0003175)2.15425368
65Bowel diverticulosis (HP:0005222)2.15132256
66Striae distensae (HP:0001065)2.14813958
67Bowed forearm bones (HP:0003956)2.12432566
68Bowing of the arm (HP:0006488)2.12432566
69Nonimmune hydrops fetalis (HP:0001790)2.11714441
70Vertebral compression fractures (HP:0002953)2.11276769
71Tibial bowing (HP:0002982)2.10404936
72Abnormality of carpal bone ossification (HP:0006257)2.08676749
73Abnormal ossification of hand bones (HP:0005921)2.07506870
74Hemangiomatosis (HP:0007461)2.05303160
75Distal lower limb amyotrophy (HP:0008944)2.05015180
76Short 1st metacarpal (HP:0010034)2.03991070
77Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.03991070
78Visceral angiomatosis (HP:0100761)2.03879309
79Disproportionate tall stature (HP:0001519)2.03875172
80Joint laxity (HP:0001388)2.03123346
81Scapular winging (HP:0003691)2.03097100
82Atrial fibrillation (HP:0005110)2.02669320
83Supraventricular arrhythmia (HP:0005115)1.99796996
84Broad ribs (HP:0000885)1.99187204
85Wide anterior fontanel (HP:0000260)1.98559362
86* Wormian bones (HP:0002645)1.98501473
87* Overgrowth (HP:0001548)1.98098958
88Mitral regurgitation (HP:0001653)1.96249104
89Tracheal stenosis (HP:0002777)1.95232160
90Conjunctival telangiectasia (HP:0000524)1.95114899
91Flat cornea (HP:0007720)1.94839596
92EMG: myopathic abnormalities (HP:0003458)1.94339278
93Venous insufficiency (HP:0005293)1.94333192
94* Wrist flexion contracture (HP:0001239)1.94075923
95Venous abnormality (HP:0002624)1.93397045
96Abnormality of the peritoneum (HP:0002585)1.92989933
97Menorrhagia (HP:0000132)1.92257948
98Abnormality of the ischium (HP:0003174)1.88822302
99Subaortic stenosis (HP:0001682)1.88119848
100Abnormality of the left ventricular outflow tract (HP:0011103)1.88119848
101Primary atrial arrhythmia (HP:0001692)1.87917218
102Biconcave vertebral bodies (HP:0004586)1.87561336
103Asymmetry of the thorax (HP:0001555)1.87439653
104* Ectopia lentis (HP:0001083)1.86152692
105Upper limb amyotrophy (HP:0009129)1.86100480
106Distal upper limb amyotrophy (HP:0007149)1.86100480
107Elbow flexion contracture (HP:0002987)1.85887304
108Premature skin wrinkling (HP:0100678)1.85406314
109Spondylolisthesis (HP:0003302)1.84723068
110Cupped ribs (HP:0000887)1.84446516
111Buphthalmos (HP:0000557)1.83385963
112Hyperacusis (HP:0010780)1.80581393
113Ovoid vertebral bodies (HP:0003300)1.79587635
114Asymmetric septal hypertrophy (HP:0001670)1.79269634
115* Coxa vara (HP:0002812)1.78798659
116Stroke (HP:0001297)1.77857190
117Flat acetabular roof (HP:0003180)1.77572556
118* Skull defect (HP:0001362)1.77278620
119Supraventricular tachycardia (HP:0004755)1.76871307
120Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76562246
121Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.76431457
122Short phalanx of the thumb (HP:0009660)1.75907757
123Abnormal delivery (HP:0001787)1.75393942
124Portal hypertension (HP:0001409)1.75139170
125Abnormality of the anterior chamber (HP:0000593)1.73933906
126Knee flexion contracture (HP:0006380)1.73856966
127* Hip contracture (HP:0003273)1.73172563
128Abnormality of the 1st metacarpal (HP:0010009)1.73097374
129* Abnormality of the acetabulum (HP:0003170)1.72832082
130Spinal cord compression (HP:0002176)1.72638263
131Flared iliac wings (HP:0002869)1.71787792
132Arachnodactyly (HP:0001166)1.71601086
133Abnormality of oral frenula (HP:0000190)1.71279833
134Rectal prolapse (HP:0002035)1.71055782
135Relative macrocephaly (HP:0004482)1.70973653
136Mitral stenosis (HP:0001718)1.70969414
137Lower limb amyotrophy (HP:0007210)1.70447796
138Limb-girdle muscle weakness (HP:0003325)1.70416687
139Protruding ear (HP:0000411)1.70399501
140Deviation of the hallux (HP:0010051)1.69807070
141Infantile muscular hypotonia (HP:0008947)1.66817555
142Osteolytic defects of the hand bones (HP:0009699)1.66555075
143Osteolytic defects of the phalanges of the hand (HP:0009771)1.66555075

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.57689786
2SCYL24.26953300
3TTN4.19412589
4TRIB33.99895394
5PKN23.19094789
6KDR2.68927739
7RIPK12.64437893
8PDGFRA2.54745866
9LATS12.37359588
10DDR22.29962563
11NTRK12.10746041
12CDK121.97428831
13DMPK1.94990556
14EPHB21.94934644
15LATS21.93290879
16SIK11.89204179
17MST1R1.82472487
18TGFBR21.76530433
19PTK61.71566398
20MAP3K101.60419827
21ERN11.51780047
22EPHA21.47768818
23PAK41.42912202
24PTK21.41071898
25PTK2B1.40123636
26BMX1.37737264
27PRPF4B1.36143855
28EEF2K1.30819819
29SIK21.30816957
30MTOR1.30672361
31FER1.29170758
32PAK21.29043757
33TGFBR11.25522911
34EPHB11.25356375
35ICK1.23810245
36CAMK1D1.23329124
37SMG11.20926333
38MYLK1.13849887
39LMTK21.12308766
40MET1.09245057
41FES1.09234048
42PRKD31.07659007
43NEK21.01092914
44MAP3K61.00955481
45NEK90.98771402
46ILK0.96460381
47CAMK1G0.96200713
48LRRK20.95854627
49PDGFRB0.92757990
50FGFR10.89554991
51OBSCN0.85015502
52STK30.84052139
53PAK30.83541632
54PRKD10.82276185
55TRPM70.81535258
56FGFR40.79375880
57ROCK10.79176641
58IRAK30.75070159
59NEK10.72302546
60MAP2K30.71201109
61PRKG20.70258041
62STK380.69679651
63PIK3CA0.68229098
64MAPK70.68220360
65PDK40.67354633
66PDK30.67354633
67RPS6KB20.67156876
68STK38L0.63855241
69MAP3K30.63669623
70FLT30.60305447
71RET0.57925215
72PHKG20.56602752
73PHKG10.56602752
74FGFR20.56159205
75CDK60.53901151
76ROCK20.51739993
77PRKCH0.51666686
78ZAP700.51027836
79CDC42BPA0.50930724
80MAP3K70.50780466
81TYRO30.50629828
82MAPKAPK30.46920973
83MAPK120.46889456
84TAOK20.46827080
85PDK20.44777450
86JAK30.42827062
87AKT20.42440435
88LIMK10.41239202
89PDPK10.40191386
90STK100.40094019
91PRKD20.40014924
92RPS6KA60.39992821
93MAP2K10.39477351
94BRD40.39271876
95SRC0.38808099
96INSR0.38338098
97FGFR30.38280425
98MAP3K130.37467797
99MAP3K80.37059810
100MOS0.36831132
101CDK90.36737657
102PIK3CG0.36085766
103MARK20.35668251
104CDK40.35602596
105CSK0.35565748
106ERBB40.34560272
107ALK0.32935694
108GSK3A0.32361172
109PRKAA20.32279188
110RPS6KA40.30530750
111KSR20.29790001
112DAPK30.28829520
113CDK80.28804948
114JAK10.28561264
115MELK0.28504783
116CDK70.26797977
117MAPK10.26438631
118AKT30.25929417
119RPS6KC10.25526438
120RPS6KL10.25526438
121EPHA30.25033999
122MAP3K10.24775994
123PAK60.24730125
124PAK10.23957699
125PRKAA10.23791578
126RPS6KA20.23356505
127WNK10.23300252
128MAP3K110.22050475
129TESK10.21291374
130ARAF0.20875805
131HIPK20.19647234
132ABL20.19640747
133SGK30.19601661

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045125.03635659
2Focal adhesion_Homo sapiens_hsa045103.31499744
3Dilated cardiomyopathy_Homo sapiens_hsa054142.97420861
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.87558573
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.80591629
6Small cell lung cancer_Homo sapiens_hsa052222.74986236
7Amoebiasis_Homo sapiens_hsa051462.72340419
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.68184859
9Adherens junction_Homo sapiens_hsa045202.36473231
10Protein digestion and absorption_Homo sapiens_hsa049742.30153316
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.00719189
12* Proteoglycans in cancer_Homo sapiens_hsa052051.97653800
13Viral myocarditis_Homo sapiens_hsa054161.93148894
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.83630127
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.78774676
16Basal cell carcinoma_Homo sapiens_hsa052171.75700398
17Tight junction_Homo sapiens_hsa045301.68777470
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65594634
19Hippo signaling pathway_Homo sapiens_hsa043901.64083368
20PI3K-Akt signaling pathway_Homo sapiens_hsa041511.58992501
21MicroRNAs in cancer_Homo sapiens_hsa052061.50715802
22Notch signaling pathway_Homo sapiens_hsa043301.43837031
23Hedgehog signaling pathway_Homo sapiens_hsa043401.43326265
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.41799894
25Toxoplasmosis_Homo sapiens_hsa051451.41075964
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.38636386
27Bladder cancer_Homo sapiens_hsa052191.36818208
28TGF-beta signaling pathway_Homo sapiens_hsa043501.30023874
29Pathways in cancer_Homo sapiens_hsa052001.23772609
30Regulation of actin cytoskeleton_Homo sapiens_hsa048101.23448488
31Lysine degradation_Homo sapiens_hsa003101.22674877
32Other glycan degradation_Homo sapiens_hsa005111.20065461
33Chronic myeloid leukemia_Homo sapiens_hsa052201.17605976
34Insulin resistance_Homo sapiens_hsa049311.14710259
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13166233
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12020451
37Complement and coagulation cascades_Homo sapiens_hsa046101.10488553
38Rap1 signaling pathway_Homo sapiens_hsa040151.08538363
39Dorso-ventral axis formation_Homo sapiens_hsa043201.07378965
40Axon guidance_Homo sapiens_hsa043601.03092162
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.02835530
42Platelet activation_Homo sapiens_hsa046111.00754945
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92293910
44Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92248845
45HIF-1 signaling pathway_Homo sapiens_hsa040660.92085705
46AMPK signaling pathway_Homo sapiens_hsa041520.91676171
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91371994
48Melanoma_Homo sapiens_hsa052180.88779194
49Renal cell carcinoma_Homo sapiens_hsa052110.88067360
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.87445878
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85398627
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84675738
53PPAR signaling pathway_Homo sapiens_hsa033200.84067548
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83296071
55Insulin signaling pathway_Homo sapiens_hsa049100.80684744
56Melanogenesis_Homo sapiens_hsa049160.79931569
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79660658
58Estrogen signaling pathway_Homo sapiens_hsa049150.79656819
59Cardiac muscle contraction_Homo sapiens_hsa042600.79467019
60mTOR signaling pathway_Homo sapiens_hsa041500.78890654
61HTLV-I infection_Homo sapiens_hsa051660.78580316
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78364530
63VEGF signaling pathway_Homo sapiens_hsa043700.78329000
64Malaria_Homo sapiens_hsa051440.77742738
65Fatty acid metabolism_Homo sapiens_hsa012120.77383284
66Fatty acid degradation_Homo sapiens_hsa000710.77159636
67Prostate cancer_Homo sapiens_hsa052150.74911029
68Glioma_Homo sapiens_hsa052140.74639841
69Glucagon signaling pathway_Homo sapiens_hsa049220.74623009
70Wnt signaling pathway_Homo sapiens_hsa043100.71622001
71Choline metabolism in cancer_Homo sapiens_hsa052310.68119872
72Endometrial cancer_Homo sapiens_hsa052130.67549867
73Carbon metabolism_Homo sapiens_hsa012000.66254249
74Gap junction_Homo sapiens_hsa045400.65932164
75Galactose metabolism_Homo sapiens_hsa000520.63426635
76Pancreatic cancer_Homo sapiens_hsa052120.63178337
77Thyroid cancer_Homo sapiens_hsa052160.61210357
78Fatty acid biosynthesis_Homo sapiens_hsa000610.59222787
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.58090782
80Propanoate metabolism_Homo sapiens_hsa006400.56532709
81Salmonella infection_Homo sapiens_hsa051320.56403781
82Colorectal cancer_Homo sapiens_hsa052100.56380776
83ErbB signaling pathway_Homo sapiens_hsa040120.55207250
84p53 signaling pathway_Homo sapiens_hsa041150.52792386
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50557547
86Thyroid hormone synthesis_Homo sapiens_hsa049180.50434809
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.50251514
88Pertussis_Homo sapiens_hsa051330.49455397
89Inositol phosphate metabolism_Homo sapiens_hsa005620.49363346
90Ovarian steroidogenesis_Homo sapiens_hsa049130.48829904
91TNF signaling pathway_Homo sapiens_hsa046680.47909486
92cAMP signaling pathway_Homo sapiens_hsa040240.47751670
93Pentose phosphate pathway_Homo sapiens_hsa000300.47427332
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47316548
95Viral carcinogenesis_Homo sapiens_hsa052030.46196374
96FoxO signaling pathway_Homo sapiens_hsa040680.44174807
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43774611
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.42919160
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.42567133
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41832311
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41388163
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41035260
103Shigellosis_Homo sapiens_hsa051310.40905270
104Ras signaling pathway_Homo sapiens_hsa040140.40829192
105Acute myeloid leukemia_Homo sapiens_hsa052210.40449136
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40354769
107N-Glycan biosynthesis_Homo sapiens_hsa005100.39955281
108Prion diseases_Homo sapiens_hsa050200.39901916
109Gastric acid secretion_Homo sapiens_hsa049710.39559075
110Oxytocin signaling pathway_Homo sapiens_hsa049210.39357972
111Endocytosis_Homo sapiens_hsa041440.38804986
112GnRH signaling pathway_Homo sapiens_hsa049120.38661074
113Renin secretion_Homo sapiens_hsa049240.38136350
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38119336
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37128400
116MAPK signaling pathway_Homo sapiens_hsa040100.36876607
117Non-small cell lung cancer_Homo sapiens_hsa052230.36040955
118Bile secretion_Homo sapiens_hsa049760.31489298
119Arginine biosynthesis_Homo sapiens_hsa002200.30925831

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