HSPH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein refolding (GO:0042026)8.23578987
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.85803258
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.50400987
4synaptic vesicle exocytosis (GO:0016079)5.50106739
5regulation of inclusion body assembly (GO:0090083)5.49277444
6synaptic vesicle maturation (GO:0016188)5.34112153
7glutamate secretion (GO:0014047)5.33641933
8regulation of synaptic vesicle exocytosis (GO:2000300)5.14974047
9axonemal dynein complex assembly (GO:0070286)5.03292192
10vocalization behavior (GO:0071625)5.02915995
11locomotory exploration behavior (GO:0035641)5.02339326
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.99562622
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.85613459
14mitotic sister chromatid cohesion (GO:0007064)4.69305575
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.68480986
16regulation of glutamate receptor signaling pathway (GO:1900449)4.65148801
17protein localization to synapse (GO:0035418)4.55471021
18regulation of synaptic vesicle transport (GO:1902803)4.52258241
19neuron cell-cell adhesion (GO:0007158)4.50989204
20synapsis (GO:0007129)4.45560622
21cilium or flagellum-dependent cell motility (GO:0001539)4.43202885
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.40404352
23neurotransmitter secretion (GO:0007269)4.38137647
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.36346407
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.28804461
26nuclear pore complex assembly (GO:0051292)4.28623258
27neuronal action potential propagation (GO:0019227)4.18093345
28regulation of neuronal synaptic plasticity (GO:0048168)4.15862294
29exploration behavior (GO:0035640)4.05049495
30positive regulation of synapse maturation (GO:0090129)4.03103565
31glutamate receptor signaling pathway (GO:0007215)4.00313992
32neuron-neuron synaptic transmission (GO:0007270)3.92362971
33piRNA metabolic process (GO:0034587)3.91330321
34synaptic transmission, glutamatergic (GO:0035249)3.87723625
35chaperone-mediated protein complex assembly (GO:0051131)3.85979653
36motile cilium assembly (GO:0044458)3.80363797
37layer formation in cerebral cortex (GO:0021819)3.78671967
38gamma-aminobutyric acid signaling pathway (GO:0007214)3.75667977
39long-term synaptic potentiation (GO:0060291)3.73012383
40neuron recognition (GO:0008038)3.69198242
41nuclear pore organization (GO:0006999)3.69123008
42long-term memory (GO:0007616)3.67363379
43regulation of meiosis I (GO:0060631)3.66315446
44regulation of synaptic plasticity (GO:0048167)3.63569187
45cilium movement (GO:0003341)3.62327175
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.61984510
47response to histamine (GO:0034776)3.59347483
48mitotic chromosome condensation (GO:0007076)3.56295736
49synaptic vesicle endocytosis (GO:0048488)3.54954152
50neurotransmitter transport (GO:0006836)3.54220548
51regulation of postsynaptic membrane potential (GO:0060078)3.53260312
52activation of protein kinase A activity (GO:0034199)3.49525748
53behavioral fear response (GO:0001662)3.49437596
54behavioral defense response (GO:0002209)3.49437596
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46321882
56regulation of dendritic spine morphogenesis (GO:0061001)3.39419162
57axonal fasciculation (GO:0007413)3.35943946
58fear response (GO:0042596)3.35018331
59microtubule depolymerization (GO:0007019)3.31582027
60regulation of centriole replication (GO:0046599)3.31567739
61positive regulation of membrane potential (GO:0045838)3.30507543
62regulation of neurotransmitter levels (GO:0001505)3.29772126
63epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.29281992
64proline transport (GO:0015824)3.28240452
65sister chromatid cohesion (GO:0007062)3.27501344
66cellular potassium ion homeostasis (GO:0030007)3.27325220
67regulation of centrosome duplication (GO:0010824)3.27125728
68dendritic spine morphogenesis (GO:0060997)3.26968275
69regulation of DNA endoreduplication (GO:0032875)3.25663009
70vesicle transport along microtubule (GO:0047496)3.25474481
71regulation of synapse structural plasticity (GO:0051823)3.24144007
72chromosome organization involved in meiosis (GO:0070192)3.23676078
73protein complex localization (GO:0031503)3.22478971
74innervation (GO:0060384)3.22212866
75regulation of neurotransmitter secretion (GO:0046928)3.21700904
76establishment of protein localization to mitochondrial membrane (GO:0090151)3.21223270
77neuromuscular process controlling posture (GO:0050884)3.20143213
78neurotransmitter-gated ion channel clustering (GO:0072578)3.20118336
79pore complex assembly (GO:0046931)3.19289683
80regulation of centrosome cycle (GO:0046605)3.18162994
81positive regulation of neurotransmitter secretion (GO:0001956)3.17536967
82transmission of nerve impulse (GO:0019226)3.16886118
83regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.16829788
84DNA synthesis involved in DNA repair (GO:0000731)3.16680309
85negative regulation of inclusion body assembly (GO:0090084)3.16525773
86mitotic metaphase plate congression (GO:0007080)3.15203748
87positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14269263
88positive regulation of neurotransmitter transport (GO:0051590)3.13764465
89regulation of vesicle fusion (GO:0031338)3.11977950
90negative regulation of synaptic transmission, GABAergic (GO:0032229)3.11961317
91G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.10203815
92positive regulation of dendritic spine morphogenesis (GO:0061003)3.09343261
93cerebellar Purkinje cell differentiation (GO:0021702)3.08525539
94metaphase plate congression (GO:0051310)3.07273206
95regulation of synaptic transmission, glutamatergic (GO:0051966)3.05049544
96epithelial cilium movement (GO:0003351)3.04917954
97gamma-aminobutyric acid transport (GO:0015812)3.04800598
98neuromuscular process controlling balance (GO:0050885)3.04684644
99regulation of glutamate secretion (GO:0014048)3.03415212
100intraspecies interaction between organisms (GO:0051703)3.02649960
101social behavior (GO:0035176)3.02649960
102cerebellar Purkinje cell layer development (GO:0021680)3.02392639
103microtubule polymerization or depolymerization (GO:0031109)3.01317552
104notochord development (GO:0030903)3.01020857
105regulation of neurotransmitter transport (GO:0051588)2.98650956
106postsynaptic membrane organization (GO:0001941)2.96795688
107cellular protein complex localization (GO:0034629)2.95805634
108mating behavior (GO:0007617)2.94426339
109chemosensory behavior (GO:0007635)2.94190363
110behavioral response to cocaine (GO:0048148)2.93194313
111resolution of meiotic recombination intermediates (GO:0000712)2.91853447
112regulation of calcium ion-dependent exocytosis (GO:0017158)2.91375627
113presynaptic membrane assembly (GO:0097105)2.91259170
114cochlea development (GO:0090102)2.91079255
115learning (GO:0007612)2.89543293
116positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.89300408
117centriole assembly (GO:0098534)2.88192371
118regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87858339
119positive regulation of synaptic transmission (GO:0050806)2.87610645
120regulation of clathrin-mediated endocytosis (GO:2000369)2.86271016
121regulation of synaptic transmission (GO:0050804)2.84693388
122regulation of dendritic spine development (GO:0060998)2.83409765
123membrane depolarization (GO:0051899)2.83358220
124apical protein localization (GO:0045176)2.83333809
125organelle transport along microtubule (GO:0072384)2.83310293
126cerebellar granule cell differentiation (GO:0021707)2.83213810
127ER overload response (GO:0006983)2.83154541
128neuromuscular process (GO:0050905)2.83023985
129prepulse inhibition (GO:0060134)2.82978866
130synaptic transmission (GO:0007268)2.82360246
131sodium ion export (GO:0071436)2.82233691
132long term synaptic depression (GO:0060292)2.82190545
133regulation of synapse maturation (GO:0090128)2.82016118
134membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.80391117
135striatum development (GO:0021756)2.80165913
136positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.79419447
137regulation of mitotic spindle organization (GO:0060236)2.78270592
138asymmetric protein localization (GO:0008105)2.77705755
139establishment of synaptic vesicle localization (GO:0097480)2.75704678
140mitotic sister chromatid segregation (GO:0000070)2.73978841
141meiotic chromosome segregation (GO:0045132)2.71680834
142positive regulation of cell size (GO:0045793)2.69853442
143sister chromatid segregation (GO:0000819)2.66348862
144male meiosis (GO:0007140)2.62029021
145male meiosis I (GO:0007141)2.60276484
146establishment of chromosome localization (GO:0051303)2.58098132
147chromosome condensation (GO:0030261)2.56470557
148centriole replication (GO:0007099)2.54684976
149DNA packaging (GO:0006323)2.50919559
150DNA unwinding involved in DNA replication (GO:0006268)2.50772326
151binding of sperm to zona pellucida (GO:0007339)2.49585843
152histone exchange (GO:0043486)2.48718325
153* chaperone mediated protein folding requiring cofactor (GO:0051085)2.48531239
154positive regulation of meiosis (GO:0045836)2.44804755
155regulation of cilium movement (GO:0003352)2.44273014
156DNA methylation involved in gamete generation (GO:0043046)2.42777707
157acrosome assembly (GO:0001675)2.42631520
158positive regulation of meiotic cell cycle (GO:0051446)2.42050136
159meiotic nuclear division (GO:0007126)2.40893096
160glucocorticoid receptor signaling pathway (GO:0042921)2.40239091
161histone H2A acetylation (GO:0043968)2.37579215
162regulation of sister chromatid cohesion (GO:0007063)2.37574209
163meiotic cell cycle (GO:0051321)2.35754064
164establishment of integrated proviral latency (GO:0075713)2.35024541
165de novo protein folding (GO:0006458)2.34026377
166axon ensheathment in central nervous system (GO:0032291)2.31675289
167central nervous system myelination (GO:0022010)2.31675289
168negative regulation of meiosis (GO:0045835)2.31177989
169CENP-A containing nucleosome assembly (GO:0034080)2.31137578
170meiotic cell cycle process (GO:1903046)2.31052265
171protein localization to chromosome, centromeric region (GO:0071459)2.30975412
172regulation of spindle organization (GO:0090224)2.30744791
173neural crest cell development (GO:0014032)2.30684361
174synaptonemal complex assembly (GO:0007130)2.27350947
175neuronal stem cell maintenance (GO:0097150)2.27216636
176protein localization to kinetochore (GO:0034501)2.26456296
177left/right axis specification (GO:0070986)2.26349669
178double-strand break repair via nonhomologous end joining (GO:0006303)2.26130368
179non-recombinational repair (GO:0000726)2.26130368
180synaptonemal complex organization (GO:0070193)2.25532641
181chromatin remodeling at centromere (GO:0031055)2.23552436
182negative regulation of oligodendrocyte differentiation (GO:0048715)2.22721655
183meiosis I (GO:0007127)2.22453841
184mitotic spindle organization (GO:0007052)2.21897086
185cell morphogenesis involved in neuron differentiation (GO:0048667)2.21133121
186de novo posttranslational protein folding (GO:0051084)2.20142645
187left/right pattern formation (GO:0060972)2.18333260
188ribosome assembly (GO:0042255)2.18123312
189regulation of chromosome segregation (GO:0051983)2.18078915
190righting reflex (GO:0060013)2.18067481
191protein localization to chromosome (GO:0034502)2.17184958
192regulation of RNA export from nucleus (GO:0046831)2.16873750
193DNA topological change (GO:0006265)2.16276003
194negative regulation of JUN kinase activity (GO:0043508)2.14213325

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.44027320
2E2F7_22180533_ChIP-Seq_HELA_Human5.36076976
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.84790256
4GBX2_23144817_ChIP-Seq_PC3_Human3.53081445
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.26205826
6RARB_27405468_Chip-Seq_BRAIN_Mouse3.13426982
7AR_21909140_ChIP-Seq_LNCAP_Human2.96552921
8REST_21632747_ChIP-Seq_MESCs_Mouse2.96226615
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88433025
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.84836507
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.83741157
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82037896
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76050601
14* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.61345120
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.56416062
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.43765581
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41495253
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40974598
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40974598
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37457902
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.34172107
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28725168
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.25632691
24TAF15_26573619_Chip-Seq_HEK293_Human2.23805297
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22664668
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15550360
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13352970
28MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13222965
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12350774
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08796742
31CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02199459
32DROSHA_22980978_ChIP-Seq_HELA_Human2.00924804
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.97600704
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89391123
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88937354
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.86750244
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.85229945
38AR_21572438_ChIP-Seq_LNCaP_Human1.83733572
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82102829
40ZNF274_21170338_ChIP-Seq_K562_Hela1.82013702
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81616771
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78632298
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.77921166
44SMAD4_21799915_ChIP-Seq_A2780_Human1.77512056
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77046880
46* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.76883376
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73862419
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71471671
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.71285951
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66214863
51FUS_26573619_Chip-Seq_HEK293_Human1.65563750
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64428023
53HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.62946641
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61222407
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.59276690
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58740801
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55538407
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.55434863
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54025585
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.50234205
61P300_19829295_ChIP-Seq_ESCs_Human1.48258016
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46373558
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.45078551
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44857638
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.44538755
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.42546359
67KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42095735
68MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40788708
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39499791
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38694301
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38446517
72CLOCK_20551151_ChIP-Seq_293T_Human1.37060768
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35093155
74* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33990004
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33808974
76* SMAD3_21741376_ChIP-Seq_EPCs_Human1.33366485
77DCP1A_22483619_ChIP-Seq_HELA_Human1.32998649
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30556475
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29414682
80SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29110001
81STAT3_23295773_ChIP-Seq_U87_Human1.29080091
82* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28273414
83AR_19668381_ChIP-Seq_PC3_Human1.27110631
84EGR1_19374776_ChIP-ChIP_THP-1_Human1.26897809
85WT1_19549856_ChIP-ChIP_CCG9911_Human1.25963264
86ZNF263_19887448_ChIP-Seq_K562_Human1.21219612
87MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20717520
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20423004
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20255218
90* AR_25329375_ChIP-Seq_VCAP_Human1.19467374
91ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19009367
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.16994202
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16774811
94ELK1_19687146_ChIP-ChIP_HELA_Human1.15142916
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.14690205
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14533139
97JUN_21703547_ChIP-Seq_K562_Human1.13785876
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13334264
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13278613
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13278613
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13278613
102RING1B_27294783_Chip-Seq_NPCs_Mouse1.12941170
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12196539
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12066641
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11591666
106PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11124742
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10153190
108BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09138698
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08765930
110POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08674338
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08652948
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.07643717
113PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07535507
114TCF4_23295773_ChIP-Seq_U87_Human1.07179279
115TP53_16413492_ChIP-PET_HCT116_Human1.04631152
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04357254
117TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.03893650
118RNF2_27304074_Chip-Seq_NSC_Mouse1.03644097
119FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03300088
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03212754
121MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02644569
122ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02551598
123NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02183513
124VDR_22108803_ChIP-Seq_LS180_Human1.01044508
125ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00420681
126IGF1R_20145208_ChIP-Seq_DFB_Human1.00030815
127ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99889896
128DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99336375
129* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99100267
130SOX9_26525672_Chip-Seq_HEART_Mouse0.99075596
131YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98248760
132RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94744522
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.94718531
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94198679
135STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94070380
136SALL1_21062744_ChIP-ChIP_HESCs_Human0.93877343
137WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93469929
138RXR_22108803_ChIP-Seq_LS180_Human0.93218960
139* TTF2_22483619_ChIP-Seq_HELA_Human0.93012889
140* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92214999
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.92132419
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92013339
143DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91131051
144RUNX2_22187159_ChIP-Seq_PCA_Human0.90392708
145ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90359040
146CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90090666
147EWS_26573619_Chip-Seq_HEK293_Human0.90011508
148MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89346285
149GABP_17652178_ChIP-ChIP_JURKAT_Human0.89249258
150TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88383861
151POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.88328787
152CBX2_27304074_Chip-Seq_ESCs_Mouse0.88200131
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87689182
154CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86544286
155* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85422128
156GATA1_26923725_Chip-Seq_HPCs_Mouse0.85217006
157POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84991176
158CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84849045
159ARNT_22903824_ChIP-Seq_MCF-7_Human0.84292438
160EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84100185
161HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84057196
162KDM2B_26808549_Chip-Seq_K562_Human0.83968726
163POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.83376252

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.01807927
2MP0003880_abnormal_central_pattern5.93974002
3MP0003635_abnormal_synaptic_transmissio4.00484425
4MP0004270_analgesia3.48110528
5MP0009745_abnormal_behavioral_response3.26237257
6MP0002063_abnormal_learning/memory/cond3.17275358
7MP0010094_abnormal_chromosome_stability3.09959798
8MP0002064_seizures3.02852026
9MP0001968_abnormal_touch/_nociception3.01279026
10MP0009046_muscle_twitch2.67409255
11MP0002572_abnormal_emotion/affect_behav2.67364184
12MP0008058_abnormal_DNA_repair2.66072763
13MP0003693_abnormal_embryo_hatching2.56749657
14MP0000579_abnormal_nail_morphology2.53425684
15MP0005423_abnormal_somatic_nervous2.48704477
16MP0001501_abnormal_sleep_pattern2.44211820
17MP0002736_abnormal_nociception_after2.41410474
18MP0008007_abnormal_cellular_replicative2.41108984
19MP0002272_abnormal_nervous_system2.35583493
20MP0009780_abnormal_chondrocyte_physiolo2.31015457
21MP0002734_abnormal_mechanical_nocicepti2.29627607
22MP0008057_abnormal_DNA_replication2.25104690
23MP0001440_abnormal_grooming_behavior2.20307162
24MP0003122_maternal_imprinting2.12459992
25MP0004957_abnormal_blastocyst_morpholog2.12214020
26MP0001486_abnormal_startle_reflex2.07452385
27MP0002822_catalepsy2.06294375
28MP0006276_abnormal_autonomic_nervous2.05215835
29MP0003077_abnormal_cell_cycle1.93662691
30MP0002735_abnormal_chemical_nociception1.87798135
31MP0003787_abnormal_imprinting1.86157929
32MP0002733_abnormal_thermal_nociception1.80959511
33MP0002067_abnormal_sensory_capabilities1.80889362
34MP0004924_abnormal_behavior1.73850667
35MP0005386_behavior/neurological_phenoty1.73850667
36MP0001529_abnormal_vocalization1.72945512
37MP0000569_abnormal_digit_pigmentation1.72040330
38MP0000778_abnormal_nervous_system1.71525101
39MP0003329_amyloid_beta_deposits1.70910965
40MP0002909_abnormal_adrenal_gland1.70833561
41MP0003111_abnormal_nucleus_morphology1.70164616
42MP0004811_abnormal_neuron_physiology1.69844743
43MP0000566_synostosis1.69567057
44MP0003123_paternal_imprinting1.69419356
45MP0002184_abnormal_innervation1.69141222
46MP0001970_abnormal_pain_threshold1.66687632
47MP0002557_abnormal_social/conspecific_i1.64559799
48MP0001929_abnormal_gametogenesis1.63926760
49MP0003136_yellow_coat_color1.62655606
50MP0008932_abnormal_embryonic_tissue1.59437140
51MP0002210_abnormal_sex_determination1.55404332
52MP0002160_abnormal_reproductive_system1.53231792
53MP0000383_abnormal_hair_follicle1.50330977
54MP0010678_abnormal_skin_adnexa1.50272864
55MP0000955_abnormal_spinal_cord1.45596976
56MP0005646_abnormal_pituitary_gland1.38667901
57MP0008569_lethality_at_weaning1.37668045
58MP0003941_abnormal_skin_development1.37337053
59MP0000350_abnormal_cell_proliferation1.34032979
60MP0003937_abnormal_limbs/digits/tail_de1.33533041
61MP0000762_abnormal_tongue_morphology1.33263597
62MP0001346_abnormal_lacrimal_gland1.33244405
63MP0002066_abnormal_motor_capabilities/c1.31984716
64MP0003698_abnormal_male_reproductive1.30107238
65MP0009053_abnormal_anal_canal1.29711480
66MP0001984_abnormal_olfaction1.28802549
67MP0010307_abnormal_tumor_latency1.27897975
68MP0002882_abnormal_neuron_morphology1.27667146
69MP0004742_abnormal_vestibular_system1.25598424
70MP0009672_abnormal_birth_weight1.25521429
71MP0002084_abnormal_developmental_patter1.25461936
72MP0003121_genomic_imprinting1.24854587
73MP0009703_decreased_birth_body1.24640180
74MP0003943_abnormal_hepatobiliary_system1.23948574
75MP0001730_embryonic_growth_arrest1.23893657
76MP0001188_hyperpigmentation1.23745956
77MP0004233_abnormal_muscle_weight1.23231326
78MP0002796_impaired_skin_barrier1.21010255
79MP0005409_darkened_coat_color1.20849871
80MP0008961_abnormal_basal_metabolism1.20501458
81MP0002152_abnormal_brain_morphology1.17926494
82MP0004145_abnormal_muscle_electrophysio1.17315454
83MP0000013_abnormal_adipose_tissue1.16669239
84MP0002009_preneoplasia1.16601856
85MP0002085_abnormal_embryonic_tissue1.15920983
86MP0004264_abnormal_extraembryonic_tissu1.14241798
87MP0001905_abnormal_dopamine_level1.14175013
88MP0001145_abnormal_male_reproductive1.13913806
89MP0002098_abnormal_vibrissa_morphology1.11541208
90MP0003879_abnormal_hair_cell1.11360189
91MP0002282_abnormal_trachea_morphology1.10812835
92MP0000467_abnormal_esophagus_morphology1.08564896
93MP0008872_abnormal_physiological_respon1.06103267
94MP0005623_abnormal_meninges_morphology1.05370639
95MP0001502_abnormal_circadian_rhythm1.05310657
96MP0004858_abnormal_nervous_system1.04203309
97MP0000653_abnormal_sex_gland1.02768623
98MP0003950_abnormal_plasma_membrane1.02517884
99MP0005187_abnormal_penis_morphology1.02513083
100MP0004885_abnormal_endolymph1.01842893
101MP0001697_abnormal_embryo_size0.99169211
102MP0008877_abnormal_DNA_methylation0.98882370
103MP0003755_abnormal_palate_morphology0.97392549
104MP0003633_abnormal_nervous_system0.95436514
105MP0005380_embryogenesis_phenotype0.95023466
106MP0001672_abnormal_embryogenesis/_devel0.95023466
107MP0005394_taste/olfaction_phenotype0.93823045
108MP0005499_abnormal_olfactory_system0.93823045
109MP0010352_gastrointestinal_tract_polyps0.93785950
110MP0004142_abnormal_muscle_tone0.93623865
111MP0002697_abnormal_eye_size0.89718323
112MP0002069_abnormal_eating/drinking_beha0.89481695
113MP0002080_prenatal_lethality0.88403041
114MP0001879_abnormal_lymphatic_vessel0.88209520
115MP0003935_abnormal_craniofacial_develop0.87936075
116MP0002161_abnormal_fertility/fecundity0.87785594
117MP0003631_nervous_system_phenotype0.87699860
118MP0003861_abnormal_nervous_system0.87419357
119MP0000647_abnormal_sebaceous_gland0.87417779
120MP0001286_abnormal_eye_development0.87072715
121MP0005171_absent_coat_pigmentation0.85495493
122MP0005076_abnormal_cell_differentiation0.85172495
123MP0005645_abnormal_hypothalamus_physiol0.84395657
124MP0003718_maternal_effect0.84205904
125MP0000631_abnormal_neuroendocrine_gland0.82259666
126MP0000432_abnormal_head_morphology0.82231801
127MP0002837_dystrophic_cardiac_calcinosis0.82209152
128MP0002653_abnormal_ependyma_morphology0.81777383
129MP0001299_abnormal_eye_distance/0.81244580
130MP0003890_abnormal_embryonic-extraembry0.80967899
131MP0002928_abnormal_bile_duct0.79925364
132MP0003315_abnormal_perineum_morphology0.78291034
133MP0010234_abnormal_vibrissa_follicle0.78161368
134MP0004197_abnormal_fetal_growth/weight/0.77768860
135MP0002938_white_spotting0.77207589
136MP0002233_abnormal_nose_morphology0.76590839
137MP0002234_abnormal_pharynx_morphology0.75737135
138MP0003283_abnormal_digestive_organ0.75226745
139MP0001177_atelectasis0.73874959
140MP0000751_myopathy0.73384905
141MP0008874_decreased_physiological_sensi0.72191978
142MP0004085_abnormal_heartbeat0.71559570
143MP0003119_abnormal_digestive_system0.69290776
144MP0004043_abnormal_pH_regulation0.67802349
145MP0003632_abnormal_nervous_system0.67620369
146MP0000747_muscle_weakness0.67379052
147MP0001943_abnormal_respiration0.66419467
148MP0005535_abnormal_body_temperature0.64627481
149MP0010769_abnormal_survival0.63310387
150MP0010770_preweaning_lethality0.63060603
151MP0002082_postnatal_lethality0.63060603
152MP0002229_neurodegeneration0.62516271
153MP0010768_mortality/aging0.59923750
154MP0002752_abnormal_somatic_nervous0.57851559
155MP0001664_abnormal_digestion0.57623932
156MP0003956_abnormal_body_size0.56172909
157MP0001485_abnormal_pinna_reflex0.55756059
158MP0002081_perinatal_lethality0.53574525
159MP0001963_abnormal_hearing_physiology0.53567219
160MP0000537_abnormal_urethra_morphology0.53398981
161MP0006072_abnormal_retinal_apoptosis0.53070509
162MP0004215_abnormal_myocardial_fiber0.52641735
163MP0004484_altered_response_of0.51480024
164MP0002751_abnormal_autonomic_nervous0.50523340

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.30467362
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.49585764
3Focal seizures (HP:0007359)5.25813774
4Myokymia (HP:0002411)5.11735724
5Atonic seizures (HP:0010819)4.72623323
6Visual hallucinations (HP:0002367)4.66858626
7Epileptic encephalopathy (HP:0200134)4.51301895
8Abnormal respiratory motile cilium physiology (HP:0012261)4.40225507
9Rhinitis (HP:0012384)4.28904320
10Abnormal respiratory motile cilium morphology (HP:0005938)4.24414833
11Abnormal respiratory epithelium morphology (HP:0012253)4.24414833
12Absence seizures (HP:0002121)4.23939610
13Absent/shortened dynein arms (HP:0200106)4.16921621
14Dynein arm defect of respiratory motile cilia (HP:0012255)4.16921621
15Dialeptic seizures (HP:0011146)3.76227766
16Febrile seizures (HP:0002373)3.70889758
17Progressive cerebellar ataxia (HP:0002073)3.59993448
18Impaired vibration sensation in the lower limbs (HP:0002166)3.47524207
19Hyperventilation (HP:0002883)3.36142994
20Generalized tonic-clonic seizures (HP:0002069)3.35819839
21Chronic bronchitis (HP:0004469)3.23800304
22Broad-based gait (HP:0002136)3.12610201
23Poor eye contact (HP:0000817)3.03642711
24Excessive salivation (HP:0003781)2.87673469
25Drooling (HP:0002307)2.87673469
26Impaired smooth pursuit (HP:0007772)2.85738442
27Urinary urgency (HP:0000012)2.82629556
28Urinary bladder sphincter dysfunction (HP:0002839)2.80808231
29Amblyopia (HP:0000646)2.80018634
30Impaired social interactions (HP:0000735)2.77971876
31Abnormal social behavior (HP:0012433)2.77971876
32Genetic anticipation (HP:0003743)2.72848647
33Insidious onset (HP:0003587)2.72628495
34Termporal pattern (HP:0011008)2.72628495
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.72215886
36Bronchiectasis (HP:0002110)2.71642575
37Truncal ataxia (HP:0002078)2.71610911
38Abnormality of the labia minora (HP:0012880)2.70320800
39Chromsome breakage (HP:0040012)2.69241943
40Depression (HP:0000716)2.69125228
41Dysdiadochokinesis (HP:0002075)2.68152281
42Epileptiform EEG discharges (HP:0011182)2.65052651
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.54706103
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.54706103
45Abnormal eating behavior (HP:0100738)2.52426118
46Abnormality of the lower motor neuron (HP:0002366)2.52136758
47Dysmetria (HP:0001310)2.46586730
48EEG with generalized epileptiform discharges (HP:0011198)2.46455802
49Increased nuchal translucency (HP:0010880)2.45830547
50Action tremor (HP:0002345)2.45345038
51Shoulder girdle muscle weakness (HP:0003547)2.42539654
52Anxiety (HP:0000739)2.38549204
53Cerebral inclusion bodies (HP:0100314)2.38270487
54Gaze-evoked nystagmus (HP:0000640)2.35716426
55Hypsarrhythmia (HP:0002521)2.33395030
56Absent speech (HP:0001344)2.33135935
57Papilledema (HP:0001085)2.32472829
58Abnormality of ocular smooth pursuit (HP:0000617)2.29551264
59Resting tremor (HP:0002322)2.28488742
60Hyperthyroidism (HP:0000836)2.24336758
61Horizontal nystagmus (HP:0000666)2.23690996
62Dysmetric saccades (HP:0000641)2.23067983
63Medulloblastoma (HP:0002885)2.17125976
64Delusions (HP:0000746)2.16701046
65Postural instability (HP:0002172)2.16599499
66Bradykinesia (HP:0002067)2.15351316
67Oligodactyly (hands) (HP:0001180)2.13248923
68Scanning speech (HP:0002168)2.13182851
69Impaired vibratory sensation (HP:0002495)2.12377300
70Supranuclear gaze palsy (HP:0000605)2.11720149
71Megalencephaly (HP:0001355)2.11653214
72Deep palmar crease (HP:0006191)2.11510975
73Stereotypic behavior (HP:0000733)2.11288892
74Abnormality of chromosome stability (HP:0003220)2.09541829
75Spastic gait (HP:0002064)2.08803305
76Ankyloglossia (HP:0010296)2.08216586
77Status epilepticus (HP:0002133)2.07639006
78Tubulointerstitial nephritis (HP:0001970)2.07098619
79Median cleft lip (HP:0000161)2.04717508
80Fetal akinesia sequence (HP:0001989)2.02302713
81Gonadotropin excess (HP:0000837)2.01177609
82Diaphragmatic weakness (HP:0009113)2.00490784
83Pointed chin (HP:0000307)1.98916279
84Abnormality of chromosome segregation (HP:0002916)1.98573777
85Abnormality of binocular vision (HP:0011514)1.95779256
86Diplopia (HP:0000651)1.95779256
87Abnormality of salivation (HP:0100755)1.95266661
88Amyotrophic lateral sclerosis (HP:0007354)1.95044117
89True hermaphroditism (HP:0010459)1.94072041
90Glioma (HP:0009733)1.93674165
91Limb dystonia (HP:0002451)1.93522492
92Protruding tongue (HP:0010808)1.92986744
93Ankle clonus (HP:0011448)1.91743190
94Missing ribs (HP:0000921)1.91565987
95Truncus arteriosus (HP:0001660)1.91004970
96Failure to thrive in infancy (HP:0001531)1.88590112
97Hemiparesis (HP:0001269)1.87690212
98Intellectual disability, profound (HP:0002187)1.87352641
99Inability to walk (HP:0002540)1.86285232
100Duodenal stenosis (HP:0100867)1.85599601
101Small intestinal stenosis (HP:0012848)1.85599601
102Split foot (HP:0001839)1.85093803
103Hypoventilation (HP:0002791)1.84919649
104Esophageal atresia (HP:0002032)1.84112817
105Annular pancreas (HP:0001734)1.83852669
106Abnormality of the carotid arteries (HP:0005344)1.82692267
107Polyphagia (HP:0002591)1.80362584
108Spinal muscular atrophy (HP:0007269)1.80287749
109Thickened helices (HP:0000391)1.80283985
110Hydroureter (HP:0000072)1.79244150
111Progressive inability to walk (HP:0002505)1.78996474
112Pelvic girdle muscle weakness (HP:0003749)1.78855339
113Glossoptosis (HP:0000162)1.78745154
114Pheochromocytoma (HP:0002666)1.77990051
115Occipital encephalocele (HP:0002085)1.76225516
116Male infertility (HP:0003251)1.75898182
117Aplasia/Hypoplasia of the uvula (HP:0010293)1.75875454
118Abnormal ciliary motility (HP:0012262)1.75527474
119Infertility (HP:0000789)1.75058170
120Generalized myoclonic seizures (HP:0002123)1.74771603
121Insomnia (HP:0100785)1.73497996
122Volvulus (HP:0002580)1.73145642
123Meckel diverticulum (HP:0002245)1.70791822
124Gait ataxia (HP:0002066)1.70307876
125Neoplasm of the heart (HP:0100544)1.70037807
126Abnormality of the corticospinal tract (HP:0002492)1.69515395
127Lower limb amyotrophy (HP:0007210)1.69436346
128Mutism (HP:0002300)1.68978250
129Hemiplegia (HP:0002301)1.68316668
130Rapidly progressive (HP:0003678)1.68281392
131Abnormality of the hip-girdle musculature (HP:0001445)1.68151376
132Abnormality of the musculature of the pelvis (HP:0001469)1.68151376
133Oligodactyly (HP:0012165)1.67692329
134Incomplete penetrance (HP:0003829)1.67094869
135Global brain atrophy (HP:0002283)1.67027134
136Unsteady gait (HP:0002317)1.66860907
137Abnormality of oral frenula (HP:0000190)1.66328530
138Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.66120956
139Aplasia/Hypoplasia of the sternum (HP:0006714)1.65386761
140Abnormality of the preputium (HP:0100587)1.65355261
141Heterotopia (HP:0002282)1.65008601
14211 pairs of ribs (HP:0000878)1.64679479
143Lower limb muscle weakness (HP:0007340)1.64432759
144Neoplasm of the oral cavity (HP:0100649)1.63583352
145Papillary thyroid carcinoma (HP:0002895)1.63264620
146Molar tooth sign on MRI (HP:0002419)1.61899625
147Abnormality of midbrain morphology (HP:0002418)1.61899625
148Nasal polyposis (HP:0100582)1.60846218
149Abnormality of the duodenum (HP:0002246)1.57626965
150Scotoma (HP:0000575)1.56831460
151Abnormal lung lobation (HP:0002101)1.55858905
152Abnormality of the ileum (HP:0001549)1.54414757
153Axonal loss (HP:0003447)1.53927913
154Cortical dysplasia (HP:0002539)1.53385170
155Spastic paraplegia (HP:0001258)1.52052524
156Gastrointestinal atresia (HP:0002589)1.51499645
157Limb-girdle muscle weakness (HP:0003325)1.51281073
158Abnormal number of incisors (HP:0011064)1.51263937
159Depressed nasal tip (HP:0000437)1.50799835
160Pancreatic fibrosis (HP:0100732)1.50478746
161Nephronophthisis (HP:0000090)1.49872006
162Aplasia involving forearm bones (HP:0009822)1.48303870
163Absent forearm bone (HP:0003953)1.48303870
164Bifid scrotum (HP:0000048)1.45130761
165Milia (HP:0001056)1.44855202
166Broad face (HP:0000283)1.44268108
167Abnormality of the anterior horn cell (HP:0006802)1.42409034
168Degeneration of anterior horn cells (HP:0002398)1.42409034
169Choanal atresia (HP:0000453)1.41490041
170Preaxial hand polydactyly (HP:0001177)1.41192247
171Rhabdomyosarcoma (HP:0002859)1.40230729
172Proximal placement of thumb (HP:0009623)1.39953186
173Type II lissencephaly (HP:0007260)1.39855822
174Upper limb muscle weakness (HP:0003484)1.38123836
175Facial cleft (HP:0002006)1.37257255
176Non-midline cleft lip (HP:0100335)1.36297425
177Vertebral arch anomaly (HP:0008438)1.35941946

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.58645422
2NTRK34.46036540
3EPHA44.38725223
4PNCK4.05539113
5MAP3K93.60633101
6MAP3K43.37496877
7TSSK63.30787378
8MINK12.60542150
9MAP2K72.24734662
10MAP3K122.14451407
11MAP2K42.04945001
12TTK2.04049721
13PLK22.03783117
14KSR21.97925541
15KSR11.93793550
16DAPK21.83700322
17PAK61.82367961
18LATS21.74322977
19CASK1.73165847
20MARK11.69547659
21EIF2AK31.67320108
22PRKD31.66025383
23RIPK41.59953118
24DAPK11.57921513
25EPHA21.56200172
26NTRK11.50091992
27BRD41.49537941
28CDK191.41042378
29NTRK21.36082875
30CDK51.31203396
31MAP3K21.29572616
32AKT31.28258324
33PLK41.26870885
34CDK121.26635551
35STK38L1.25816995
36GRK51.24602043
37ARAF1.24428475
38NME11.23665224
39CAMKK11.20810829
40STK381.17326495
41PRKCG1.14990048
42STK391.14360166
43RAF11.09429296
44NEK11.05786598
45MKNK21.05437494
46PBK1.04843399
47MST41.02350638
48SIK21.02247699
49CDK181.02082417
50UHMK11.01182634
51CDK141.01032300
52TYRO31.00588535
53VRK11.00512582
54ALK0.98830280
55SCYL20.97588147
56BRSK20.97283113
57CDK150.97114648
58SRPK10.96467723
59FES0.94887874
60CDK30.93892754
61MAP3K130.93014957
62CAMK2A0.89881561
63ACVR1B0.87941423
64OXSR10.86893548
65CCNB10.86172637
66CDK11A0.86162599
67MST1R0.84796988
68MET0.83744348
69CAMK2B0.82987745
70WNK30.80336135
71PLK10.79757530
72PLK30.79152074
73ERBB40.77556243
74TAF10.77428802
75STK110.77043006
76FER0.76720354
77NEK60.76502543
78LATS10.74480939
79TRIM280.73393205
80DYRK1A0.72098755
81PTK2B0.71678673
82SGK4940.71096563
83SGK2230.71096563
84CSNK1E0.70540091
85TAOK10.68390482
86CDC70.66577401
87CHEK20.65602481
88BMPR1B0.65568744
89SMG10.61908993
90RET0.61302140
91SGK10.60964355
92SGK20.60512364
93MAPKAPK50.60345149
94BMPR20.59839630
95SIK30.58843213
96DMPK0.58545912
97CSNK1G20.57844600
98CHEK10.57389934
99YES10.56763115
100BRAF0.55937449
101PAK30.54557496
102MKNK10.54449921
103* MAPK100.54248442
104CDK80.53082348
105BRSK10.52916765
106MAPK130.52871811
107MAP3K10.52217186
108ATM0.51678046
109ROCK20.50826695
110BUB10.49391444
111CAMKK20.49171639
112MOS0.48662353
113ATR0.47516944
114EIF2AK10.46766539
115CDK90.46420858
116SGK30.46332992
117FGFR10.45206095
118RPS6KA30.44516702
119MAP2K10.43837120
120PRKCH0.42450870
121WEE10.42061523
122BCR0.40911716
123PDGFRA0.40889101
124CAMK10.40788488
125ERBB30.39708493
126PRKCZ0.37194200
127CDK10.37078529
128CDK70.36741921
129AURKA0.36649638
130AURKB0.36620774
131GRK60.36445323
132PRPF4B0.35821405
133PRKDC0.34487391
134EIF2AK20.33904177
135MAP3K100.33631619
136TGFBR10.33442364
137CAMK2D0.33115179
138PASK0.31831633
139MAP3K70.31635440
140PDK10.31526216
141CSNK1A10.31411895
142MAP3K50.31118606
143PDGFRB0.31082216
144MAP3K60.30967448
145PAK20.30655741
146RPS6KB20.30650037
147PRKCI0.30590963
148CAMK2G0.30298607
149PDPK10.30108862
150STK30.29542194
151PTK20.29469019
152FGR0.29224055
153MELK0.28505685
154CAMK1G0.28003225
155STK240.26415114
156RPS6KB10.26355587
157CDK20.25015814
158MTOR0.24539983

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.80368775
2Synaptic vesicle cycle_Homo sapiens_hsa047213.30185146
3Long-term potentiation_Homo sapiens_hsa047203.03613150
4Amphetamine addiction_Homo sapiens_hsa050312.88347149
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58058247
6GABAergic synapse_Homo sapiens_hsa047272.57613431
7Circadian entrainment_Homo sapiens_hsa047132.46785048
8Cell cycle_Homo sapiens_hsa041102.44673185
9Non-homologous end-joining_Homo sapiens_hsa034502.44205937
10DNA replication_Homo sapiens_hsa030302.41367050
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.37796253
12Olfactory transduction_Homo sapiens_hsa047402.36158224
13Dopaminergic synapse_Homo sapiens_hsa047282.33315515
14Spliceosome_Homo sapiens_hsa030402.31498166
15Glutamatergic synapse_Homo sapiens_hsa047242.29784946
16Mismatch repair_Homo sapiens_hsa034302.28166648
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26421436
18Morphine addiction_Homo sapiens_hsa050322.24183354
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17487166
20Fanconi anemia pathway_Homo sapiens_hsa034602.11013162
21* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.05581148
22Insulin secretion_Homo sapiens_hsa049112.05341709
23Salivary secretion_Homo sapiens_hsa049702.02593034
24Cocaine addiction_Homo sapiens_hsa050301.88095746
25Gastric acid secretion_Homo sapiens_hsa049711.81835988
26Long-term depression_Homo sapiens_hsa047301.80232578
27Nucleotide excision repair_Homo sapiens_hsa034201.79108956
28Renin secretion_Homo sapiens_hsa049241.75773437
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73774080
30Protein export_Homo sapiens_hsa030601.71741423
31Taste transduction_Homo sapiens_hsa047421.69969143
32Collecting duct acid secretion_Homo sapiens_hsa049661.68214419
33Cholinergic synapse_Homo sapiens_hsa047251.64573979
34Basal transcription factors_Homo sapiens_hsa030221.62954410
35Oxytocin signaling pathway_Homo sapiens_hsa049211.62536996
36Serotonergic synapse_Homo sapiens_hsa047261.59685677
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57548979
38Gap junction_Homo sapiens_hsa045401.53286446
39Oocyte meiosis_Homo sapiens_hsa041141.52842008
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51458672
41Estrogen signaling pathway_Homo sapiens_hsa049151.51190249
42GnRH signaling pathway_Homo sapiens_hsa049121.50274700
43Calcium signaling pathway_Homo sapiens_hsa040201.41660789
44Steroid biosynthesis_Homo sapiens_hsa001001.35206407
45Homologous recombination_Homo sapiens_hsa034401.26225445
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25913999
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25165281
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19680962
49Vibrio cholerae infection_Homo sapiens_hsa051101.18929280
50Melanogenesis_Homo sapiens_hsa049161.18551406
51TGF-beta signaling pathway_Homo sapiens_hsa043501.17854007
52Glioma_Homo sapiens_hsa052141.15723405
53Dorso-ventral axis formation_Homo sapiens_hsa043201.15435261
54Base excision repair_Homo sapiens_hsa034101.14982608
55Basal cell carcinoma_Homo sapiens_hsa052171.14035272
56cAMP signaling pathway_Homo sapiens_hsa040241.13511039
57RNA degradation_Homo sapiens_hsa030181.11001749
58Adherens junction_Homo sapiens_hsa045201.10028204
59Legionellosis_Homo sapiens_hsa051341.07915942
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04632133
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04625577
62ErbB signaling pathway_Homo sapiens_hsa040121.04440039
63Tight junction_Homo sapiens_hsa045301.03347191
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99060598
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98852682
66Prostate cancer_Homo sapiens_hsa052150.94249902
67Thyroid hormone synthesis_Homo sapiens_hsa049180.92156073
68Type II diabetes mellitus_Homo sapiens_hsa049300.91868582
69Cardiac muscle contraction_Homo sapiens_hsa042600.89306450
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89074195
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88222107
72Folate biosynthesis_Homo sapiens_hsa007900.88214400
73Axon guidance_Homo sapiens_hsa043600.86657679
74Vitamin B6 metabolism_Homo sapiens_hsa007500.85901845
75MAPK signaling pathway_Homo sapiens_hsa040100.85230391
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.84480398
77Selenocompound metabolism_Homo sapiens_hsa004500.84418494
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83938777
79Type I diabetes mellitus_Homo sapiens_hsa049400.80129549
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80110107
81Glucagon signaling pathway_Homo sapiens_hsa049220.79635196
82p53 signaling pathway_Homo sapiens_hsa041150.78680467
83Prion diseases_Homo sapiens_hsa050200.76963261
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75956597
85Circadian rhythm_Homo sapiens_hsa047100.74863520
86Pancreatic secretion_Homo sapiens_hsa049720.73675338
87Wnt signaling pathway_Homo sapiens_hsa043100.73648455
88Proteasome_Homo sapiens_hsa030500.73520990
89MicroRNAs in cancer_Homo sapiens_hsa052060.73020674
90Fatty acid biosynthesis_Homo sapiens_hsa000610.70992612
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70882350
92mTOR signaling pathway_Homo sapiens_hsa041500.70705642
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70192997
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69475777
95Choline metabolism in cancer_Homo sapiens_hsa052310.68928496
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68875888
97Nitrogen metabolism_Homo sapiens_hsa009100.63882468
98VEGF signaling pathway_Homo sapiens_hsa043700.63553400
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60534773
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.60034708
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59577573
102beta-Alanine metabolism_Homo sapiens_hsa004100.58684533
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.58285592
104Alzheimers disease_Homo sapiens_hsa050100.55425243
105Renal cell carcinoma_Homo sapiens_hsa052110.54095405
106Dilated cardiomyopathy_Homo sapiens_hsa054140.53272997
107Hedgehog signaling pathway_Homo sapiens_hsa043400.53138538
108RNA polymerase_Homo sapiens_hsa030200.51525145
109Alcoholism_Homo sapiens_hsa050340.50144213
110Epstein-Barr virus infection_Homo sapiens_hsa051690.49585161
111Rap1 signaling pathway_Homo sapiens_hsa040150.49077556
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.48350382
113Proteoglycans in cancer_Homo sapiens_hsa052050.46814440
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46337273
115Ras signaling pathway_Homo sapiens_hsa040140.45942084
116mRNA surveillance pathway_Homo sapiens_hsa030150.45119244
117Pathways in cancer_Homo sapiens_hsa052000.44387781
118Oxidative phosphorylation_Homo sapiens_hsa001900.43051480
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42731893
120Melanoma_Homo sapiens_hsa052180.42474535
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42414860
122Colorectal cancer_Homo sapiens_hsa052100.42332993
123Phototransduction_Homo sapiens_hsa047440.41083649
124Non-small cell lung cancer_Homo sapiens_hsa052230.41032315
125Small cell lung cancer_Homo sapiens_hsa052220.40146234
126Insulin signaling pathway_Homo sapiens_hsa049100.39538205
127Inositol phosphate metabolism_Homo sapiens_hsa005620.39151180
128Thyroid cancer_Homo sapiens_hsa052160.38282871
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.37763567
130Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37737375
131Endometrial cancer_Homo sapiens_hsa052130.37588513
132Huntingtons disease_Homo sapiens_hsa050160.37547440
133Parkinsons disease_Homo sapiens_hsa050120.37255442
134N-Glycan biosynthesis_Homo sapiens_hsa005100.36916994
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36570000
136Endocytosis_Homo sapiens_hsa041440.34645669
137Hippo signaling pathway_Homo sapiens_hsa043900.34482340
138RNA transport_Homo sapiens_hsa030130.34003372
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32473423
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30472575
141Bladder cancer_Homo sapiens_hsa052190.29655650
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29057234
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.28325832

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