Rank | Gene Set | Z-score |
---|---|---|
1 | L-phenylalanine catabolic process (GO:0006559) | 5.00953967 |
2 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 5.00953967 |
3 | L-phenylalanine metabolic process (GO:0006558) | 4.98800637 |
4 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 4.98800637 |
5 | neutrophil activation involved in immune response (GO:0002283) | 4.87823231 |
6 | aromatic amino acid family catabolic process (GO:0009074) | 4.60649931 |
7 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 4.51886684 |
8 | cysteine metabolic process (GO:0006534) | 4.39923646 |
9 | indole-containing compound catabolic process (GO:0042436) | 4.29421127 |
10 | indolalkylamine catabolic process (GO:0046218) | 4.29421127 |
11 | tryptophan catabolic process (GO:0006569) | 4.29421127 |
12 | tryptophan metabolic process (GO:0006568) | 4.20798830 |
13 | protein carboxylation (GO:0018214) | 4.18775409 |
14 | peptidyl-glutamic acid carboxylation (GO:0017187) | 4.18775409 |
15 | urea metabolic process (GO:0019627) | 4.15063533 |
16 | urea cycle (GO:0000050) | 4.15063533 |
17 | polyketide metabolic process (GO:0030638) | 4.13635184 |
18 | doxorubicin metabolic process (GO:0044598) | 4.13635184 |
19 | daunorubicin metabolic process (GO:0044597) | 4.13635184 |
20 | kynurenine metabolic process (GO:0070189) | 4.13132742 |
21 | aldehyde catabolic process (GO:0046185) | 4.11683104 |
22 | high-density lipoprotein particle remodeling (GO:0034375) | 4.07057942 |
23 | sulfur amino acid catabolic process (GO:0000098) | 4.05305726 |
24 | bile acid biosynthetic process (GO:0006699) | 3.99203758 |
25 | nitrogen cycle metabolic process (GO:0071941) | 3.88872342 |
26 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 3.84885163 |
27 | regulation of protein activation cascade (GO:2000257) | 3.83245091 |
28 | glyoxylate metabolic process (GO:0046487) | 3.79123050 |
29 | amino-acid betaine metabolic process (GO:0006577) | 3.78248443 |
30 | phospholipid efflux (GO:0033700) | 3.76909903 |
31 | regulation of cholesterol esterification (GO:0010872) | 3.74803362 |
32 | negative regulation of fibrinolysis (GO:0051918) | 3.74410862 |
33 | regulation of triglyceride catabolic process (GO:0010896) | 3.73714758 |
34 | epoxygenase P450 pathway (GO:0019373) | 3.71631226 |
35 | complement activation, alternative pathway (GO:0006957) | 3.70725469 |
36 | regulation of complement activation (GO:0030449) | 3.65170420 |
37 | aminoglycoside antibiotic metabolic process (GO:0030647) | 3.60170562 |
38 | plasma lipoprotein particle clearance (GO:0034381) | 3.58807216 |
39 | aromatic amino acid family metabolic process (GO:0009072) | 3.55259672 |
40 | plasma lipoprotein particle remodeling (GO:0034369) | 3.53404256 |
41 | protein-lipid complex remodeling (GO:0034368) | 3.53404256 |
42 | macromolecular complex remodeling (GO:0034367) | 3.53404256 |
43 | cyclooxygenase pathway (GO:0019371) | 3.51413119 |
44 | serine family amino acid catabolic process (GO:0009071) | 3.50958498 |
45 | reverse cholesterol transport (GO:0043691) | 3.50703056 |
46 | alpha-linolenic acid metabolic process (GO:0036109) | 3.46747989 |
47 | regulation of fibrinolysis (GO:0051917) | 3.44606643 |
48 | cofactor catabolic process (GO:0051187) | 3.44573938 |
49 | homocysteine metabolic process (GO:0050667) | 3.42799897 |
50 | tyrosine metabolic process (GO:0006570) | 3.42393208 |
51 | lysine metabolic process (GO:0006553) | 3.40129587 |
52 | lysine catabolic process (GO:0006554) | 3.40129587 |
53 | ethanol oxidation (GO:0006069) | 3.38229943 |
54 | bile acid metabolic process (GO:0008206) | 3.33818698 |
55 | glycoside metabolic process (GO:0016137) | 3.31905818 |
56 | glycolipid catabolic process (GO:0019377) | 3.28488589 |
57 | glycosphingolipid catabolic process (GO:0046479) | 3.27192875 |
58 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.23878706 |
59 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.23878706 |
60 | drug catabolic process (GO:0042737) | 3.23489578 |
61 | cholesterol efflux (GO:0033344) | 3.21206305 |
62 | plasma lipoprotein particle assembly (GO:0034377) | 3.19539568 |
63 | cellular glucuronidation (GO:0052695) | 3.16091848 |
64 | carnitine metabolic process (GO:0009437) | 3.15610026 |
65 | benzene-containing compound metabolic process (GO:0042537) | 3.13239314 |
66 | NAD biosynthetic process (GO:0009435) | 3.13121216 |
67 | fibrinolysis (GO:0042730) | 3.13117341 |
68 | nicotinamide nucleotide biosynthetic process (GO:0019359) | 3.12615678 |
69 | pyridine nucleotide biosynthetic process (GO:0019363) | 3.12615678 |
70 | indolalkylamine metabolic process (GO:0006586) | 3.10374578 |
71 | negative regulation of cholesterol transport (GO:0032375) | 3.09461783 |
72 | negative regulation of sterol transport (GO:0032372) | 3.09461783 |
73 | alpha-amino acid catabolic process (GO:1901606) | 3.08067614 |
74 | acylglycerol homeostasis (GO:0055090) | 3.07476094 |
75 | triglyceride homeostasis (GO:0070328) | 3.07476094 |
76 | serine family amino acid metabolic process (GO:0009069) | 3.07126061 |
77 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.06813795 |
78 | cellular biogenic amine catabolic process (GO:0042402) | 3.06313906 |
79 | amine catabolic process (GO:0009310) | 3.06313906 |
80 | uronic acid metabolic process (GO:0006063) | 3.05853979 |
81 | glucuronate metabolic process (GO:0019585) | 3.05853979 |
82 | glycine metabolic process (GO:0006544) | 3.05224970 |
83 | peptide catabolic process (GO:0043171) | 3.00230319 |
84 | xenobiotic catabolic process (GO:0042178) | 3.00082256 |
85 | bile acid and bile salt transport (GO:0015721) | 2.99976181 |
86 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 2.99311416 |
87 | positive regulation of Cdc42 GTPase activity (GO:0043089) | 2.98229423 |
88 | pyrimidine nucleoside catabolic process (GO:0046135) | 2.95231629 |
89 | acute-phase response (GO:0006953) | 2.93210924 |
90 | positive regulation of lipid catabolic process (GO:0050996) | 2.93173467 |
91 | pentose-phosphate shunt (GO:0006098) | 2.92446911 |
92 | plasma lipoprotein particle organization (GO:0071827) | 2.91812658 |
93 | low-density lipoprotein particle remodeling (GO:0034374) | 2.90970318 |
94 | ethanol metabolic process (GO:0006067) | 2.90608930 |
95 | protein maturation by protein folding (GO:0022417) | 2.90409807 |
96 | flavonoid metabolic process (GO:0009812) | 2.90138056 |
97 | primary alcohol catabolic process (GO:0034310) | 2.89749817 |
98 | complement activation, classical pathway (GO:0006958) | 2.89297262 |
99 | response to nitrosative stress (GO:0051409) | 2.87204086 |
100 | complement activation (GO:0006956) | 2.86369354 |
101 | serine family amino acid biosynthetic process (GO:0009070) | 2.86281000 |
102 | exogenous drug catabolic process (GO:0042738) | 2.85831679 |
103 | protein-lipid complex assembly (GO:0065005) | 2.85687588 |
104 | blood coagulation, intrinsic pathway (GO:0007597) | 2.84175457 |
105 | cellular amino acid catabolic process (GO:0009063) | 2.82956892 |
106 | NADPH regeneration (GO:0006740) | 2.82864690 |
107 | protein activation cascade (GO:0072376) | 2.81894649 |
108 | alkaloid metabolic process (GO:0009820) | 2.81703174 |
109 | arginine metabolic process (GO:0006525) | 2.81684030 |
110 | imidazole-containing compound metabolic process (GO:0052803) | 2.81229393 |
111 | heme metabolic process (GO:0042168) | 2.79786969 |
112 | fatty acid oxidation (GO:0019395) | 2.79017473 |
113 | phospholipid homeostasis (GO:0055091) | 2.78923490 |
114 | oligosaccharide catabolic process (GO:0009313) | 2.76435122 |
115 | cholesterol homeostasis (GO:0042632) | 2.76244433 |
116 | neutrophil activation (GO:0042119) | 2.68921908 |
117 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.65822681 |
118 | granulocyte activation (GO:0036230) | 2.65538512 |
119 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 2.64012515 |
120 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.61267018 |
121 | ceramide catabolic process (GO:0046514) | 2.57353629 |
122 | response to peptidoglycan (GO:0032494) | 2.54619613 |
123 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.54251188 |
124 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 2.53365377 |
125 | Golgi transport vesicle coating (GO:0048200) | 2.52947209 |
126 | COPI coating of Golgi vesicle (GO:0048205) | 2.52947209 |
127 | NIK/NF-kappaB signaling (GO:0038061) | 2.51260707 |
128 | NADH metabolic process (GO:0006734) | 2.48802304 |
129 | progesterone metabolic process (GO:0042448) | 2.48160700 |
130 | immunoglobulin mediated immune response (GO:0016064) | 2.45600624 |
131 | regulation of superoxide anion generation (GO:0032928) | 2.45094257 |
132 | glucose catabolic process (GO:0006007) | 2.44423825 |
133 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 2.43938873 |
134 | lipoxygenase pathway (GO:0019372) | 2.43397975 |
135 | proteasome assembly (GO:0043248) | 2.42330385 |
136 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 2.40563013 |
137 | regulation of metalloenzyme activity (GO:0048552) | 2.39078741 |
138 | fat-soluble vitamin biosynthetic process (GO:0042362) | 2.36755303 |
139 | B cell mediated immunity (GO:0019724) | 2.35920015 |
140 | membrane lipid catabolic process (GO:0046466) | 2.35547829 |
141 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 2.35032265 |
142 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.34003091 |
143 | antigen processing and presentation of endogenous antigen (GO:0019883) | 2.33297938 |
144 | regulation of vitamin metabolic process (GO:0030656) | 2.32614192 |
145 | nucleotide-sugar biosynthetic process (GO:0009226) | 2.31766942 |
146 | pentose metabolic process (GO:0019321) | 2.29197506 |
147 | GDP-mannose metabolic process (GO:0019673) | 2.28217951 |
148 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.25244106 |
149 | negative regulation of protein localization to plasma membrane (GO:1903077) | 2.24656023 |
150 | sphingolipid catabolic process (GO:0030149) | 2.23900396 |
151 | NADP metabolic process (GO:0006739) | 2.23602937 |
152 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.22569236 |
153 | arachidonic acid metabolic process (GO:0019369) | 2.20724126 |
154 | regulation of RIG-I signaling pathway (GO:0039535) | 2.20353957 |
155 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 2.19791307 |
156 | glucose 6-phosphate metabolic process (GO:0051156) | 2.19613123 |
157 | ribosome assembly (GO:0042255) | 2.17391415 |
158 | cellular response to cadmium ion (GO:0071276) | 2.16105710 |
159 | positive regulation of cellular amine metabolic process (GO:0033240) | 2.15970959 |
160 | detection of other organism (GO:0098543) | 2.14625988 |
161 | negative regulation of release of cytochrome c from mitochondria (GO:0090201) | 2.14013612 |
162 | regulation of interferon-beta biosynthetic process (GO:0045357) | 2.13318093 |
163 | pyrimidine-containing compound salvage (GO:0008655) | 2.12247312 |
164 | pyrimidine nucleoside salvage (GO:0043097) | 2.12247312 |
165 | cellular response to arsenic-containing substance (GO:0071243) | 2.12228712 |
166 | nucleoside diphosphate biosynthetic process (GO:0009133) | 2.11306601 |
167 | detection of bacterium (GO:0016045) | 2.09089565 |
168 | positive regulation by symbiont of host defense response (GO:0052509) | 2.08254547 |
169 | modulation by symbiont of host defense response (GO:0052031) | 2.08254547 |
170 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 2.08254547 |
171 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 2.08254547 |
172 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 2.08254547 |
173 | modulation by symbiont of host immune response (GO:0052553) | 2.08254547 |
174 | hormone catabolic process (GO:0042447) | 2.07189538 |
175 | positive regulation of leukocyte degranulation (GO:0043302) | 2.06743422 |
176 | regulation of podosome assembly (GO:0071801) | 2.06584032 |
177 | thrombin receptor signaling pathway (GO:0070493) | 2.05296749 |
178 | negative regulation of hemostasis (GO:1900047) | 2.03372706 |
179 | negative regulation of blood coagulation (GO:0030195) | 2.03372706 |
180 | pinocytosis (GO:0006907) | 2.02504627 |
181 | mitochondrial calcium ion transport (GO:0006851) | 2.01997291 |
182 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.01697028 |
Rank | Gene Set | Z-score |
---|---|---|
1 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 7.26639838 |
2 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 5.03574358 |
3 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 4.54829990 |
4 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 4.22291547 |
5 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.07710750 |
6 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 3.79751757 |
7 | * LXR_22158963_ChIP-Seq_LIVER_Mouse | 3.60299383 |
8 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.52762310 |
9 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 2.97642273 |
10 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.88366486 |
11 | GATA1_22025678_ChIP-Seq_K562_Human | 2.62598520 |
12 | * IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.33916797 |
13 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.30100468 |
14 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.20541887 |
15 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.12773938 |
16 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.09212280 |
17 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.98709444 |
18 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.95579617 |
19 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.92974938 |
20 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.92288809 |
21 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.88267042 |
22 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.85158769 |
23 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.81245217 |
24 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.79464531 |
25 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.69397663 |
26 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.64143947 |
27 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.57775698 |
28 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.55800285 |
29 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.55503513 |
30 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.54242696 |
31 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.53566357 |
32 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.49644969 |
33 | * Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.48047176 |
34 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.46138824 |
35 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.43121376 |
36 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.38583765 |
37 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.36201731 |
38 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.35913196 |
39 | * SOX2_20726797_ChIP-Seq_SW620_Human | 1.35881420 |
40 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.35533931 |
41 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.35426312 |
42 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.35395475 |
43 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.31536102 |
44 | * GATA6_25053715_ChIP-Seq_YYC3_Human | 1.30285838 |
45 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.30157248 |
46 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.27943295 |
47 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.27936275 |
48 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.27936275 |
49 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.25131583 |
50 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.24924695 |
51 | SPI1_23127762_ChIP-Seq_K562_Human | 1.23951094 |
52 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.23068206 |
53 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.22342302 |
54 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.22137398 |
55 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.21987723 |
56 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.20467650 |
57 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.18747038 |
58 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.17927356 |
59 | * RACK7_27058665_Chip-Seq_MCF-7_Human | 1.16172364 |
60 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.15997012 |
61 | * ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.15124379 |
62 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.14291268 |
63 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.14277008 |
64 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.14230413 |
65 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.13129601 |
66 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.12504245 |
67 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.10683487 |
68 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.10482154 |
69 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.10006039 |
70 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.09708524 |
71 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.08183712 |
72 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.07200200 |
73 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.07098860 |
74 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.06370531 |
75 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.04900292 |
76 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.03933637 |
77 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.03421173 |
78 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.02970807 |
79 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.02928057 |
80 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.02876816 |
81 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.02053316 |
82 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.01880488 |
83 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.01621305 |
84 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.00650692 |
85 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.99017609 |
86 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.97994913 |
87 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.97648554 |
88 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.97399252 |
89 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.97139424 |
90 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.96851275 |
91 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.95635547 |
92 | * CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.95514912 |
93 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 0.94966734 |
94 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.93941405 |
95 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93852034 |
96 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.93602741 |
97 | MAF_26560356_Chip-Seq_TH1_Human | 0.93258487 |
98 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.92831990 |
99 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.91904849 |
100 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.89991084 |
101 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.88596425 |
102 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.87833870 |
103 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 0.87772481 |
104 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.87691470 |
105 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.87651070 |
106 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.87395446 |
107 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.86523766 |
108 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.86461840 |
109 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.86236308 |
110 | MYB_26560356_Chip-Seq_TH1_Human | 0.86162635 |
111 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.85831843 |
112 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.84996397 |
113 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.83377280 |
114 | MYB_26560356_Chip-Seq_TH2_Human | 0.82837047 |
115 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.82030795 |
116 | * SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.81594981 |
117 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.81500481 |
118 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.80843620 |
119 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.80405625 |
120 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.79621869 |
121 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 0.79299688 |
122 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 0.77890757 |
123 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.76944102 |
124 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.76345095 |
125 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.76302049 |
126 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.75480499 |
127 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.75389542 |
128 | ATF3_27146783_Chip-Seq_COLON_Human | 0.75368246 |
129 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.74886453 |
130 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.74782472 |
131 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.73397432 |
132 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 0.72499014 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 5.46215505 |
2 | MP0005360_urolithiasis | 5.06326655 |
3 | MP0005085_abnormal_gallbladder_physiolo | 4.29362330 |
4 | MP0005365_abnormal_bile_salt | 4.16413180 |
5 | MP0003806_abnormal_nucleotide_metabolis | 4.03503647 |
6 | MP0008875_abnormal_xenobiotic_pharmacok | 3.80284026 |
7 | MP0009840_abnormal_foam_cell | 3.13603326 |
8 | MP0005083_abnormal_biliary_tract | 2.73360466 |
9 | MP0010329_abnormal_lipoprotein_level | 2.53780580 |
10 | MP0003191_abnormal_cellular_cholesterol | 2.52606391 |
11 | MP0003656_abnormal_erythrocyte_physiolo | 2.48908698 |
12 | MP0003252_abnormal_bile_duct | 2.39788121 |
13 | MP0003186_abnormal_redox_activity | 2.30024434 |
14 | MP0003195_calcinosis | 2.28181779 |
15 | MP0005332_abnormal_amino_acid | 2.10349063 |
16 | MP0002877_abnormal_melanocyte_morpholog | 1.97873775 |
17 | MP0003436_decreased_susceptibility_to | 1.97074428 |
18 | MP0000609_abnormal_liver_physiology | 1.92852772 |
19 | MP0001666_abnormal_nutrient_absorption | 1.89876724 |
20 | MP0005319_abnormal_enzyme/_coenzyme | 1.81631928 |
21 | MP0001835_abnormal_antigen_presentation | 1.81282418 |
22 | MP0009785_altered_susceptibility_to | 1.78827240 |
23 | MP0008004_abnormal_stomach_pH | 1.77945316 |
24 | MP0010352_gastrointestinal_tract_polyps | 1.71328326 |
25 | MP0002138_abnormal_hepatobiliary_system | 1.70609494 |
26 | MP0005058_abnormal_lysosome_morphology | 1.63585574 |
27 | MP0001764_abnormal_homeostasis | 1.60124107 |
28 | MP0005464_abnormal_platelet_physiology | 1.59236424 |
29 | MP0009764_decreased_sensitivity_to | 1.59091941 |
30 | MP0003566_abnormal_cell_adhesion | 1.58925695 |
31 | MP0004019_abnormal_vitamin_homeostasis | 1.58496894 |
32 | MP0002118_abnormal_lipid_homeostasis | 1.55593342 |
33 | MP0008469_abnormal_protein_level | 1.51441592 |
34 | MP0008260_abnormal_autophagy | 1.49088725 |
35 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.44988449 |
36 | MP0003453_abnormal_keratinocyte_physiol | 1.44747549 |
37 | MP0005025_abnormal_response_to | 1.43771070 |
38 | MP0009643_abnormal_urine_homeostasis | 1.42216336 |
39 | MP0003724_increased_susceptibility_to | 1.41377925 |
40 | MP0002148_abnormal_hypersensitivity_rea | 1.40702768 |
41 | MP0000465_gastrointestinal_hemorrhage | 1.40562695 |
42 | MP0002419_abnormal_innate_immunity | 1.36821593 |
43 | MP0005451_abnormal_body_composition | 1.35916270 |
44 | MP0000685_abnormal_immune_system | 1.35770537 |
45 | MP0001853_heart_inflammation | 1.31228539 |
46 | MP0006082_CNS_inflammation | 1.30480579 |
47 | MP0000604_amyloidosis | 1.27878680 |
48 | MP0005636_abnormal_mineral_homeostasis | 1.26593511 |
49 | MP0005501_abnormal_skin_physiology | 1.25532592 |
50 | MP0004947_skin_inflammation | 1.25355975 |
51 | MP0000490_abnormal_crypts_of | 1.22740801 |
52 | MP0004264_abnormal_extraembryonic_tissu | 1.20998672 |
53 | MP0006036_abnormal_mitochondrial_physio | 1.19578784 |
54 | MP0009763_increased_sensitivity_to | 1.19253964 |
55 | MP0003866_abnormal_defecation | 1.17143880 |
56 | MP0005000_abnormal_immune_tolerance | 1.16891409 |
57 | MP0005165_increased_susceptibility_to | 1.16723539 |
58 | MP0001845_abnormal_inflammatory_respons | 1.16718870 |
59 | MP0009697_abnormal_copulation | 1.16013735 |
60 | MP0000598_abnormal_liver_morphology | 1.15792781 |
61 | MP0005671_abnormal_response_to | 1.11436645 |
62 | MP0001800_abnormal_humoral_immune | 1.10462830 |
63 | MP0004147_increased_porphyrin_level | 1.08934067 |
64 | MP0001790_abnormal_immune_system | 1.05022241 |
65 | MP0005387_immune_system_phenotype | 1.05022241 |
66 | MP0002723_abnormal_immune_serum | 1.02541099 |
67 | MP0002166_altered_tumor_susceptibility | 1.02054427 |
68 | MP0003172_abnormal_lysosome_physiology | 1.02042807 |
69 | MP0003705_abnormal_hypodermis_morpholog | 1.00641913 |
70 | MP0002452_abnormal_antigen_presenting | 1.00615089 |
71 | MP0000343_altered_response_to | 0.99678524 |
72 | MP0004957_abnormal_blastocyst_morpholog | 0.99473435 |
73 | MP0001756_abnormal_urination | 0.99234950 |
74 | MP0001873_stomach_inflammation | 0.99073634 |
75 | MP0003448_altered_tumor_morphology | 0.97117178 |
76 | MP0002132_abnormal_respiratory_system | 0.94639019 |
77 | MP0005408_hypopigmentation | 0.93655508 |
78 | MP0001533_abnormal_skeleton_physiology | 0.93407307 |
79 | MP0009765_abnormal_xenobiotic_induced | 0.93079548 |
80 | MP0003183_abnormal_peptide_metabolism | 0.90762879 |
81 | MP0002405_respiratory_system_inflammati | 0.88973411 |
82 | MP0001216_abnormal_epidermal_layer | 0.88682275 |
83 | MP0004782_abnormal_surfactant_physiolog | 0.88553756 |
84 | MP0002136_abnormal_kidney_physiology | 0.87560075 |
85 | MP0009642_abnormal_blood_homeostasis | 0.87385418 |
86 | MP0001819_abnormal_immune_cell | 0.87367236 |
87 | MP0002420_abnormal_adaptive_immunity | 0.87094172 |
88 | MP0001542_abnormal_bone_strength | 0.86973760 |
89 | MP0002006_tumorigenesis | 0.86596540 |
90 | MP0001881_abnormal_mammary_gland | 0.85167850 |
91 | MP0002796_impaired_skin_barrier | 0.83234743 |
92 | MP0005376_homeostasis/metabolism_phenot | 0.82363661 |
93 | MP0010155_abnormal_intestine_physiology | 0.81998554 |
94 | MP0001851_eye_inflammation | 0.81666592 |
95 | MP0002254_reproductive_system_inflammat | 0.80786938 |
96 | MP0009333_abnormal_splenocyte_physiolog | 0.80716954 |
97 | MP0000689_abnormal_spleen_morphology | 0.78399125 |
98 | MP0002998_abnormal_bone_remodeling | 0.78333751 |
99 | MP0003300_gastrointestinal_ulcer | 0.78196112 |
100 | MP0005164_abnormal_response_to | 0.76558772 |
101 | MP0003868_abnormal_feces_composition | 0.76502547 |
102 | MP0005397_hematopoietic_system_phenotyp | 0.76485467 |
103 | MP0001545_abnormal_hematopoietic_system | 0.76485467 |
104 | MP0003763_abnormal_thymus_physiology | 0.75997756 |
105 | MP0004510_myositis | 0.73661506 |
106 | MP0006035_abnormal_mitochondrial_morpho | 0.72859390 |
107 | MP0003011_delayed_dark_adaptation | 0.72587311 |
108 | MP0005023_abnormal_wound_healing | 0.69614194 |
109 | MP0000716_abnormal_immune_system | 0.69180044 |
110 | MP0002722_abnormal_immune_system | 0.68997161 |
111 | MP0002876_abnormal_thyroid_physiology | 0.68760391 |
112 | MP0008873_increased_physiological_sensi | 0.67781054 |
113 | MP0005266_abnormal_metabolism | 0.66772530 |
114 | MP0003303_peritoneal_inflammation | 0.66704128 |
115 | MP0006054_spinal_hemorrhage | 0.65756016 |
116 | MP0002398_abnormal_bone_marrow | 0.65568910 |
117 | MP0005166_decreased_susceptibility_to | 0.65465927 |
118 | MP0002429_abnormal_blood_cell | 0.65367376 |
119 | * MP0000858_altered_metastatic_potential | 0.63495618 |
120 | MP0003075_altered_response_to | 0.63349996 |
121 | MP0010234_abnormal_vibrissa_follicle | 0.62522421 |
122 | MP0002060_abnormal_skin_morphology | 0.61935756 |
123 | MP0001243_abnormal_dermal_layer | 0.60805759 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 5.05275341 |
2 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 5.04556377 |
3 | Intrahepatic cholestasis (HP:0001406) | 4.62772545 |
4 | Hypobetalipoproteinemia (HP:0003563) | 4.55316604 |
5 | Deep venous thrombosis (HP:0002625) | 4.52628277 |
6 | Xanthomatosis (HP:0000991) | 4.51621782 |
7 | Prolonged partial thromboplastin time (HP:0003645) | 4.24869139 |
8 | Hyperlipoproteinemia (HP:0010980) | 3.91385181 |
9 | Joint hemorrhage (HP:0005261) | 3.67644833 |
10 | Abnormality of glycolipid metabolism (HP:0010969) | 3.54659319 |
11 | Abnormality of liposaccharide metabolism (HP:0010968) | 3.54659319 |
12 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 3.54659319 |
13 | Complement deficiency (HP:0004431) | 3.49773257 |
14 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 3.48513528 |
15 | Hyperammonemia (HP:0001987) | 3.47563222 |
16 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.40865462 |
17 | Hypolipoproteinemia (HP:0010981) | 3.37044797 |
18 | Abnormality of the common coagulation pathway (HP:0010990) | 3.36833589 |
19 | Hyperbilirubinemia (HP:0002904) | 3.23401960 |
20 | Systemic lupus erythematosus (HP:0002725) | 3.22255385 |
21 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.19698637 |
22 | Prolonged bleeding time (HP:0003010) | 3.16617014 |
23 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 3.16069504 |
24 | Increased mean platelet volume (HP:0011877) | 3.15668455 |
25 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 3.09927920 |
26 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.08617099 |
27 | Abnormal platelet volume (HP:0011876) | 3.08255960 |
28 | Conjugated hyperbilirubinemia (HP:0002908) | 3.06475365 |
29 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.05090043 |
30 | Fat malabsorption (HP:0002630) | 3.04714461 |
31 | Abnormality of methionine metabolism (HP:0010901) | 2.94406326 |
32 | Abnormality of complement system (HP:0005339) | 2.94384870 |
33 | Abnormality of the intrinsic pathway (HP:0010989) | 2.92044089 |
34 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.90365552 |
35 | Hypoalphalipoproteinemia (HP:0003233) | 2.83723288 |
36 | Hyperglycinuria (HP:0003108) | 2.83471828 |
37 | Ketosis (HP:0001946) | 2.80459490 |
38 | Eczematoid dermatitis (HP:0000976) | 2.78546960 |
39 | Myocardial infarction (HP:0001658) | 2.77874259 |
40 | Hyperglycinemia (HP:0002154) | 2.77266347 |
41 | Hypoglycemic coma (HP:0001325) | 2.71054149 |
42 | Epidermoid cyst (HP:0200040) | 2.70128948 |
43 | Hepatosplenomegaly (HP:0001433) | 2.68636801 |
44 | Vacuolated lymphocytes (HP:0001922) | 2.65625100 |
45 | Poikilocytosis (HP:0004447) | 2.64911226 |
46 | Nausea (HP:0002018) | 2.62454223 |
47 | Abnormality of nucleobase metabolism (HP:0010932) | 2.58454023 |
48 | Hypercholesterolemia (HP:0003124) | 2.57031854 |
49 | Abnormality of glycine metabolism (HP:0010895) | 2.55538449 |
50 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.55538449 |
51 | Acanthocytosis (HP:0001927) | 2.52378365 |
52 | Dysostosis multiplex (HP:0000943) | 2.51767151 |
53 | Steatorrhea (HP:0002570) | 2.50325297 |
54 | Abnormality of iron homeostasis (HP:0011031) | 2.48273167 |
55 | Abnormality of transition element cation homeostasis (HP:0011030) | 2.47990555 |
56 | Metabolic acidosis (HP:0001942) | 2.47209400 |
57 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.46687877 |
58 | Dicarboxylic aciduria (HP:0003215) | 2.46687877 |
59 | Autoimmune thrombocytopenia (HP:0001973) | 2.44214109 |
60 | Increased serum ferritin (HP:0003281) | 2.42778873 |
61 | Vascular calcification (HP:0004934) | 2.41056956 |
62 | Loss of speech (HP:0002371) | 2.41002247 |
63 | Progressive neurologic deterioration (HP:0002344) | 2.40773951 |
64 | Pustule (HP:0200039) | 2.39726429 |
65 | Cholelithiasis (HP:0001081) | 2.38517067 |
66 | Recurrent bacterial skin infections (HP:0005406) | 2.36885160 |
67 | Recurrent abscess formation (HP:0002722) | 2.36672573 |
68 | Abnormal gallbladder morphology (HP:0012437) | 2.35062677 |
69 | Abnormality of purine metabolism (HP:0004352) | 2.33372486 |
70 | Gingival bleeding (HP:0000225) | 2.29744003 |
71 | Lethargy (HP:0001254) | 2.26598622 |
72 | Abnormality of serum amino acid levels (HP:0003112) | 2.26370851 |
73 | Glomerulonephritis (HP:0000099) | 2.26244334 |
74 | Hepatocellular carcinoma (HP:0001402) | 2.22177953 |
75 | Purpura (HP:0000979) | 2.21728275 |
76 | Axonal loss (HP:0003447) | 2.20502314 |
77 | Tetraparesis (HP:0002273) | 2.17755354 |
78 | Cerebral edema (HP:0002181) | 2.15807330 |
79 | Cardiovascular calcification (HP:0011915) | 2.15557885 |
80 | Menorrhagia (HP:0000132) | 2.12572693 |
81 | Generalized aminoaciduria (HP:0002909) | 2.11814499 |
82 | Hypochromic microcytic anemia (HP:0004840) | 2.10664807 |
83 | Amyloidosis (HP:0011034) | 2.08702229 |
84 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.08582360 |
85 | Mucopolysacchariduria (HP:0008155) | 2.08582360 |
86 | Increased cerebral lipofuscin (HP:0011813) | 2.07374634 |
87 | Hydroxyprolinuria (HP:0003080) | 2.07234433 |
88 | Abnormality of proline metabolism (HP:0010907) | 2.07234433 |
89 | Malnutrition (HP:0004395) | 2.06773273 |
90 | Petechiae (HP:0000967) | 2.06279587 |
91 | Vomiting (HP:0002013) | 2.05867454 |
92 | Obstructive lung disease (HP:0006536) | 2.05579569 |
93 | Chronic obstructive pulmonary disease (HP:0006510) | 2.05579569 |
94 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.05393612 |
95 | Urticaria (HP:0001025) | 2.05203743 |
96 | Vertebral compression fractures (HP:0002953) | 2.02155599 |
97 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.02130427 |
98 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.02130427 |
99 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.02130427 |
100 | Impaired platelet aggregation (HP:0003540) | 2.00329439 |
101 | Abnormal platelet function (HP:0011869) | 2.00329439 |
102 | Hypokinesia (HP:0002375) | 1.99582468 |
103 | Pancreatitis (HP:0001733) | 1.99544352 |
104 | Osteolytic defects of the hand bones (HP:0009699) | 1.98613575 |
105 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.98613575 |
106 | Abnormality of macrophages (HP:0004311) | 1.97053396 |
107 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.97006422 |
108 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.97006422 |
109 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.96541886 |
110 | Micronodular cirrhosis (HP:0001413) | 1.95367638 |
111 | Opisthotonus (HP:0002179) | 1.95143425 |
112 | Sensorimotor neuropathy (HP:0007141) | 1.92729254 |
113 | Reticulocytosis (HP:0001923) | 1.91762591 |
114 | Microcytic anemia (HP:0001935) | 1.91416382 |
115 | Hypertriglyceridemia (HP:0002155) | 1.91346258 |
116 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 1.90382801 |
117 | Alkalosis (HP:0001948) | 1.89082652 |
118 | Skin nodule (HP:0200036) | 1.88999471 |
119 | Increased IgM level (HP:0003496) | 1.88648754 |
120 | Bone pain (HP:0002653) | 1.88386672 |
121 | Rough bone trabeculation (HP:0100670) | 1.87421154 |
122 | Abnormality of the gallbladder (HP:0005264) | 1.87357807 |
123 | Epistaxis (HP:0000421) | 1.86912419 |
124 | Ketoacidosis (HP:0001993) | 1.86541621 |
125 | Joint swelling (HP:0001386) | 1.86050196 |
126 | Brushfield spots (HP:0001088) | 1.85287171 |
127 | Prolonged neonatal jaundice (HP:0006579) | 1.85171860 |
128 | Spontaneous abortion (HP:0005268) | 1.83919968 |
129 | Abnormal cartilage morphology (HP:0002763) | 1.83760182 |
130 | Paralysis (HP:0003470) | 1.83374144 |
131 | Irritability (HP:0000737) | 1.82939033 |
132 | Abnormal gallbladder physiology (HP:0012438) | 1.82874178 |
133 | Orchitis (HP:0100796) | 1.79880468 |
134 | Orthostatic hypotension (HP:0001278) | 1.78222334 |
135 | Rickets (HP:0002748) | 1.76968369 |
136 | Autoimmune hemolytic anemia (HP:0001890) | 1.75509467 |
137 | Anorexia (HP:0002039) | 1.74892781 |
138 | Abnormality of the Achilles tendon (HP:0005109) | 1.73911520 |
139 | Abnormal trabecular bone morphology (HP:0100671) | 1.73400234 |
140 | Cardiomegaly (HP:0001640) | 1.72738542 |
141 | Conjunctival telangiectasia (HP:0000524) | 1.72701892 |
142 | Symptomatic seizures (HP:0011145) | 1.72467467 |
143 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.72301782 |
144 | Right ventricular cardiomyopathy (HP:0011663) | 1.71635985 |
145 | Stomatitis (HP:0010280) | 1.67895825 |
146 | Myositis (HP:0100614) | 1.67810129 |
147 | Abnormal pupillary function (HP:0007686) | 1.66150893 |
148 | Reduced antithrombin III activity (HP:0001976) | 1.65076644 |
Rank | Gene Set | Z-score |
---|---|---|
1 | ERN1 | 3.34782401 |
2 | BCKDK | 3.27122732 |
3 | PIM2 | 3.16167344 |
4 | NME2 | 2.86596046 |
5 | BLK | 2.60430984 |
6 | TBK1 | 2.52166533 |
7 | MAP3K14 | 2.34682278 |
8 | TYK2 | 2.29753888 |
9 | MAP4K1 | 2.29043796 |
10 | EIF2AK1 | 2.28895372 |
11 | NEK9 | 2.25159443 |
12 | FGFR4 | 2.12471858 |
13 | MAP3K11 | 2.10667717 |
14 | IRAK3 | 2.01396668 |
15 | ZAP70 | 1.96184699 |
16 | ARAF | 1.88282321 |
17 | MAP3K3 | 1.79052980 |
18 | MST1R | 1.78327825 |
19 | TAOK3 | 1.76880744 |
20 | TESK1 | 1.74697153 |
21 | IKBKE | 1.70383359 |
22 | TRIB3 | 1.68897641 |
23 | MAP2K3 | 1.67123456 |
24 | KDR | 1.53038025 |
25 | BMX | 1.48591724 |
26 | ABL2 | 1.40120388 |
27 | BMPR2 | 1.39484860 |
28 | IRAK4 | 1.36584050 |
29 | PIM1 | 1.32528244 |
30 | FRK | 1.32359544 |
31 | KIT | 1.29704813 |
32 | IKBKB | 1.28671894 |
33 | SCYL2 | 1.28549803 |
34 | RIPK4 | 1.28497943 |
35 | JAK1 | 1.28208764 |
36 | PKN2 | 1.27533768 |
37 | MAPKAPK3 | 1.27496129 |
38 | JAK3 | 1.21601392 |
39 | STK24 | 1.19568783 |
40 | PBK | 1.19563297 |
41 | TXK | 1.18022294 |
42 | SYK | 1.17364515 |
43 | MET | 1.16028213 |
44 | FLT3 | 1.14135593 |
45 | TEC | 1.02265937 |
46 | GRK6 | 1.01948181 |
47 | ILK | 1.00849192 |
48 | MAP3K12 | 1.00434666 |
49 | RPS6KA4 | 0.99118079 |
50 | LMTK2 | 0.97612118 |
51 | MST4 | 0.94714418 |
52 | JAK2 | 0.94371730 |
53 | MAP3K5 | 0.92887198 |
54 | MYLK | 0.89182667 |
55 | TESK2 | 0.88351606 |
56 | LRRK2 | 0.87104772 |
57 | DAPK1 | 0.86829767 |
58 | EIF2AK3 | 0.86498079 |
59 | CDK6 | 0.85005526 |
60 | PRPF4B | 0.84958019 |
61 | NEK1 | 0.82944330 |
62 | RPS6KB2 | 0.82819416 |
63 | SIK1 | 0.82257242 |
64 | PIK3CG | 0.81811981 |
65 | BRAF | 0.81214123 |
66 | PDK3 | 0.80788182 |
67 | PDK4 | 0.80788182 |
68 | MAPK11 | 0.78916071 |
69 | STK10 | 0.75685095 |
70 | STK16 | 0.75574026 |
71 | SIK3 | 0.74566196 |
72 | VRK2 | 0.73636911 |
73 | STK4 | 0.73114237 |
74 | FER | 0.73025080 |
75 | ZAK | 0.72288993 |
76 | BTK | 0.69541534 |
77 | MATK | 0.68169458 |
78 | SMG1 | 0.67214204 |
79 | EPHA3 | 0.66764577 |
80 | PRKG2 | 0.65295443 |
81 | ACVR1B | 0.65019148 |
82 | IRAK1 | 0.64813140 |
83 | YES1 | 0.64497691 |
84 | IRAK2 | 0.64297688 |
85 | FGR | 0.63852562 |
86 | TAOK2 | 0.63828603 |
87 | CHUK | 0.63619439 |
88 | ERBB4 | 0.63450179 |
89 | PAK1 | 0.60533909 |
90 | LYN | 0.60100134 |
91 | PRKCI | 0.59829164 |
92 | CSK | 0.59323589 |
93 | MARK3 | 0.57995406 |
94 | MAP3K1 | 0.56480596 |
95 | MAP2K1 | 0.55713416 |
96 | TRPM7 | 0.55290460 |
97 | NME1 | 0.53564338 |
98 | ALK | 0.53050908 |
99 | MAP3K8 | 0.51997235 |
100 | PDK2 | 0.50924137 |
101 | LCK | 0.50892465 |
102 | PDPK1 | 0.50123200 |
103 | BUB1 | 0.49701042 |
104 | EPHB1 | 0.49463324 |
105 | LIMK1 | 0.48086461 |
106 | DYRK1B | 0.46736025 |
107 | TAOK1 | 0.46671536 |
108 | PRKCD | 0.46208169 |
109 | PTK2 | 0.46128137 |
110 | MAP2K2 | 0.44942122 |
111 | CSF1R | 0.44891096 |
112 | RIPK1 | 0.44092178 |
113 | EPHA2 | 0.43142848 |
114 | MAP2K6 | 0.42243766 |
115 | DAPK3 | 0.40797410 |
116 | MAP3K2 | 0.40209245 |
117 | RAF1 | 0.39955430 |
118 | PTK6 | 0.38427098 |
119 | TGFBR2 | 0.37522165 |
120 | TTK | 0.37405017 |
121 | FGFR3 | 0.36047003 |
122 | MAP3K13 | 0.35938208 |
123 | MAPKAPK2 | 0.35497394 |
124 | HCK | 0.35364586 |
125 | PAK4 | 0.35319979 |
126 | BRSK2 | 0.35295826 |
127 | CAMK2G | 0.34688770 |
128 | KSR2 | 0.31511101 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 3.63874505 |
2 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 2.93213319 |
3 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.81419278 |
4 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.59495052 |
5 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.46580302 |
6 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.42147931 |
7 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.34558720 |
8 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.32301274 |
9 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.31395929 |
10 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.16977226 |
11 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.16553869 |
12 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 2.16519024 |
13 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 2.09810285 |
14 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.06478831 |
15 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.02974716 |
16 | Peroxisome_Homo sapiens_hsa04146 | 2.02292312 |
17 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.00118149 |
18 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.84261282 |
19 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.82156678 |
20 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.78192699 |
21 | Histidine metabolism_Homo sapiens_hsa00340 | 1.73771294 |
22 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.68858071 |
23 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.66866840 |
24 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.64755060 |
25 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.58338740 |
26 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.57531582 |
27 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.57525263 |
28 | Retinol metabolism_Homo sapiens_hsa00830 | 1.57064278 |
29 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.56534775 |
30 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.51181445 |
31 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.51178524 |
32 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.43137336 |
33 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.38958753 |
34 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.35382509 |
35 | Sulfur relay system_Homo sapiens_hsa04122 | 1.33522342 |
36 | Proteasome_Homo sapiens_hsa03050 | 1.32735233 |
37 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.32645804 |
38 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.31113519 |
39 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.26765991 |
40 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.26086316 |
41 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.24644012 |
42 | Carbon metabolism_Homo sapiens_hsa01200 | 1.24585415 |
43 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.23529016 |
44 | ABC transporters_Homo sapiens_hsa02010 | 1.20116333 |
45 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.19134771 |
46 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.17861776 |
47 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.15158029 |
48 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.14072917 |
49 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.13645233 |
50 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.08583746 |
51 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.07081389 |
52 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.07024503 |
53 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.03063202 |
54 | Shigellosis_Homo sapiens_hsa05131 | 1.01740275 |
55 | Bile secretion_Homo sapiens_hsa04976 | 0.97647219 |
56 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.96654859 |
57 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.91425518 |
58 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.91242122 |
59 | Mineral absorption_Homo sapiens_hsa04978 | 0.90872247 |
60 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.90849562 |
61 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.90761276 |
62 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.89762984 |
63 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.88676347 |
64 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.85739497 |
65 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.84798245 |
66 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.84179615 |
67 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.83356570 |
68 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.81590407 |
69 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.81361150 |
70 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.75335051 |
71 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.74626848 |
72 | Salmonella infection_Homo sapiens_hsa05132 | 0.72734811 |
73 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.72330217 |
74 | Hepatitis C_Homo sapiens_hsa05160 | 0.71924444 |
75 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.70736702 |
76 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.69903491 |
77 | Platelet activation_Homo sapiens_hsa04611 | 0.68684556 |
78 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.66698951 |
79 | Lysosome_Homo sapiens_hsa04142 | 0.64709338 |
80 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.63415322 |
81 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.63091189 |
82 | Mismatch repair_Homo sapiens_hsa03430 | 0.62669009 |
83 | Legionellosis_Homo sapiens_hsa05134 | 0.62509932 |
84 | Galactose metabolism_Homo sapiens_hsa00052 | 0.61777576 |
85 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.60636955 |
86 | Influenza A_Homo sapiens_hsa05164 | 0.58648193 |
87 | Other glycan degradation_Homo sapiens_hsa00511 | 0.57514711 |
88 | Metabolic pathways_Homo sapiens_hsa01100 | 0.56971774 |
89 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.56579220 |
90 | Asthma_Homo sapiens_hsa05310 | 0.56165623 |
91 | Leishmaniasis_Homo sapiens_hsa05140 | 0.54353888 |
92 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.52858054 |
93 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.52349462 |
94 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.52326424 |
95 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.52168553 |
96 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.51652328 |
97 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.50362148 |
98 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.50341510 |
99 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.48056296 |
100 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.47457189 |
101 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.47441766 |
102 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.47140083 |
103 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.45325217 |
104 | Protein export_Homo sapiens_hsa03060 | 0.41051390 |
105 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.39097952 |
106 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.38231792 |
107 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.37733511 |
108 | Pertussis_Homo sapiens_hsa05133 | 0.37493007 |
109 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.35725929 |
110 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.35634239 |
111 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.33541225 |
112 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.33132311 |
113 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.33057380 |
114 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.32830902 |
115 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.30953070 |
116 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.29747273 |
117 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.29738034 |
118 | Malaria_Homo sapiens_hsa05144 | 0.29589952 |
119 | Apoptosis_Homo sapiens_hsa04210 | 0.29120820 |
120 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.29117525 |
121 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.28536892 |
122 | Phagosome_Homo sapiens_hsa04145 | 0.27624099 |
123 | Measles_Homo sapiens_hsa05162 | 0.24024009 |
124 | Tuberculosis_Homo sapiens_hsa05152 | 0.23918852 |
125 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.23000281 |
126 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.22893568 |
127 | Ribosome_Homo sapiens_hsa03010 | 0.22880391 |
128 | Allograft rejection_Homo sapiens_hsa05330 | 0.21633281 |