HTATSF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)3.78494730
2mitotic sister chromatid cohesion (GO:0007064)3.64283160
3positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.59213012
4mRNA splice site selection (GO:0006376)3.30178773
5cardiac myofibril assembly (GO:0055003)3.22502448
6positive regulation of synapse maturation (GO:0090129)3.19081903
7pyrimidine nucleobase catabolic process (GO:0006208)3.07353257
8muscle filament sliding (GO:0030049)3.05898176
9actin-myosin filament sliding (GO:0033275)3.05898176
10DNA topological change (GO:0006265)3.04937548
11cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.04200637
12establishment of mitochondrion localization (GO:0051654)3.00660540
13CENP-A containing nucleosome assembly (GO:0034080)2.98412679
14ATP-dependent chromatin remodeling (GO:0043044)2.95808496
15cell communication by electrical coupling (GO:0010644)2.95682210
16chromatin remodeling at centromere (GO:0031055)2.95457312
17regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.95112682
18negative regulation of potassium ion transmembrane transport (GO:1901380)2.93068074
19regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.92228013
20histone H2B ubiquitination (GO:0033523)2.89814215
21sarcoplasmic reticulum calcium ion transport (GO:0070296)2.88319648
22formation of translation preinitiation complex (GO:0001731)2.84606892
23regulation of acyl-CoA biosynthetic process (GO:0050812)2.79751756
24establishment of viral latency (GO:0019043)2.79589350
25regulation of coenzyme metabolic process (GO:0051196)2.77419261
26regulation of cofactor metabolic process (GO:0051193)2.77419261
27DNA replication-independent nucleosome assembly (GO:0006336)2.76546985
28DNA replication-independent nucleosome organization (GO:0034724)2.76546985
29positive regulation of dendritic spine morphogenesis (GO:0061003)2.76091379
30DNA ligation (GO:0006266)2.75814051
31interkinetic nuclear migration (GO:0022027)2.74823055
32cardiac muscle contraction (GO:0060048)2.74727100
33DNA damage response, detection of DNA damage (GO:0042769)2.72502700
34myofibril assembly (GO:0030239)2.72277688
35histone exchange (GO:0043486)2.71843187
36negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.69285842
37sarcomere organization (GO:0045214)2.69071927
38protein localization to kinetochore (GO:0034501)2.67074503
39non-recombinational repair (GO:0000726)2.64893912
40double-strand break repair via nonhomologous end joining (GO:0006303)2.64893912
41membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.64860643
42regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.64628605
43cell migration in hindbrain (GO:0021535)2.64446794
44regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.63525404
45sister chromatid cohesion (GO:0007062)2.63378827
46gonadal mesoderm development (GO:0007506)2.62999384
47ribosome assembly (GO:0042255)2.61726280
48negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61441491
49negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.60556194
50regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.60497939
51resolution of meiotic recombination intermediates (GO:0000712)2.60289888
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.60072889
53detection of calcium ion (GO:0005513)2.58887678
54actin-mediated cell contraction (GO:0070252)2.58636989
55nucleosome disassembly (GO:0006337)2.58519304
56protein-DNA complex disassembly (GO:0032986)2.58519304
57negative regulation of norepinephrine secretion (GO:0010700)2.57773316
58nucleus localization (GO:0051647)2.56189471
59regulation of membrane repolarization (GO:0060306)2.53741652
60mitotic metaphase plate congression (GO:0007080)2.52813838
61positive regulation of RNA splicing (GO:0033120)2.52701048
62regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.50406974
63positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.49865362
64cerebral cortex radially oriented cell migration (GO:0021799)2.48900663
65alternative mRNA splicing, via spliceosome (GO:0000380)2.47881654
66regulation of centriole replication (GO:0046599)2.47594116
67protein localization to chromosome, centromeric region (GO:0071459)2.47437045
68mRNA splicing, via spliceosome (GO:0000398)2.46932129
69RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.46932129
70negative regulation of DNA recombination (GO:0045910)2.46709912
71sister chromatid segregation (GO:0000819)2.46707857
72presynaptic membrane organization (GO:0097090)2.45831597
73presynaptic membrane assembly (GO:0097105)2.45238493
74regulation of synapse maturation (GO:0090128)2.44178311
75atrial cardiac muscle cell action potential (GO:0086014)2.44092336
76DNA strand elongation involved in DNA replication (GO:0006271)2.43820183
77RNA splicing, via transesterification reactions (GO:0000375)2.43476474
78mitotic spindle organization (GO:0007052)2.41696224
79striated muscle contraction (GO:0006941)2.40544048
80nucleobase catabolic process (GO:0046113)2.40479104
81synapsis (GO:0007129)2.39922853
82DNA unwinding involved in DNA replication (GO:0006268)2.39886739
83DNA synthesis involved in DNA repair (GO:0000731)2.38660532
84regulation of sarcomere organization (GO:0060297)2.37893271
85DNA strand elongation (GO:0022616)2.37254235
86stress granule assembly (GO:0034063)2.36231213
87substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.36104915
88substrate-independent telencephalic tangential migration (GO:0021826)2.36104915
89peptidyl-lysine dimethylation (GO:0018027)2.35735900
90plasma membrane repair (GO:0001778)2.34203615
91regulation of cell communication by electrical coupling (GO:0010649)2.33998292
92postsynaptic membrane organization (GO:0001941)2.33844504
93negative regulation of mRNA processing (GO:0050686)2.33793473
94metaphase plate congression (GO:0051310)2.33608743
95neuron recognition (GO:0008038)2.32422993
96innervation (GO:0060384)2.32398790
97protein localization to chromosome (GO:0034502)2.32127042
98neuron cell-cell adhesion (GO:0007158)2.31989860
99regulation of sulfur metabolic process (GO:0042762)2.31264719
100mitotic sister chromatid segregation (GO:0000070)2.31103447
101somite development (GO:0061053)2.30894084
102regulation of RNA export from nucleus (GO:0046831)2.30374285
103layer formation in cerebral cortex (GO:0021819)2.29662046
104membrane repolarization during action potential (GO:0086011)2.29488961
105mitochondrion transport along microtubule (GO:0047497)2.28766374
106establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.28766374
107DNA replication-dependent nucleosome organization (GO:0034723)2.28551679
108DNA replication-dependent nucleosome assembly (GO:0006335)2.28551679
109negative regulation of RNA splicing (GO:0033119)2.28094555
110regulation of transcription from RNA polymerase I promoter (GO:0006356)2.27524619
111termination of RNA polymerase II transcription (GO:0006369)2.27227127
112DNA replication checkpoint (GO:0000076)2.26646816
113central nervous system projection neuron axonogenesis (GO:0021952)2.26005412
114regulation of skeletal muscle contraction (GO:0014819)2.24679599
115IMP metabolic process (GO:0046040)2.24524209
116regulation of synaptic vesicle exocytosis (GO:2000300)2.24460594
117axonal fasciculation (GO:0007413)2.23911826
118dendritic spine organization (GO:0097061)2.23886533
119peptidyl-arginine methylation (GO:0018216)2.23765801
120peptidyl-arginine N-methylation (GO:0035246)2.23765801
121synaptic vesicle exocytosis (GO:0016079)2.23676924
122negative regulation of histone methylation (GO:0031061)2.23353941
123protein localization to synapse (GO:0035418)2.23237050
124regulation of synapse structural plasticity (GO:0051823)2.23105382
125membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.22903108
126regulation of DNA endoreduplication (GO:0032875)2.22300908
127meiotic chromosome segregation (GO:0045132)2.22001941
128dendritic spine morphogenesis (GO:0060997)2.21964208
129nuclear pore organization (GO:0006999)2.20248461
130regulation of meiosis I (GO:0060631)2.20096288
131cytoplasmic mRNA processing body assembly (GO:0033962)2.19743737
132IMP biosynthetic process (GO:0006188)2.19646450
133spliceosomal tri-snRNP complex assembly (GO:0000244)2.19553155
134regulation of potassium ion transmembrane transport (GO:1901379)2.19420702
135regulation of mRNA splicing, via spliceosome (GO:0048024)2.19062081
136telomere maintenance via semi-conservative replication (GO:0032201)2.18983307
137establishment of nucleus localization (GO:0040023)2.18851634
138hippocampus development (GO:0021766)2.18058221
139cell communication involved in cardiac conduction (GO:0086065)2.17929970
140glucocorticoid receptor signaling pathway (GO:0042921)2.17572185
141regulation of short-term neuronal synaptic plasticity (GO:0048172)2.16924157
142chromatin assembly or disassembly (GO:0006333)2.16625107
143positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.16223972
144positive regulation of dendrite morphogenesis (GO:0050775)2.15312037
145histone H3-K4 trimethylation (GO:0080182)2.15099147
146regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.15003148
147cardiac muscle cell development (GO:0055013)2.14462510
148positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.13000586
149peptidyl-arginine omega-N-methylation (GO:0035247)2.12837447
150ventricular cardiac muscle cell action potential (GO:0086005)2.11633605
151pyrimidine dimer repair (GO:0006290)2.11351624
152negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.10966580
153positive regulation of chromosome segregation (GO:0051984)2.10763850
154positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.10670079
155kinetochore organization (GO:0051383)2.10607645
156chromosome organization involved in meiosis (GO:0070192)2.10594966
157pore complex assembly (GO:0046931)2.10514657
158regulation of potassium ion transmembrane transporter activity (GO:1901016)2.10121336
159regulation of synaptic vesicle transport (GO:1902803)2.08879435
160male sex determination (GO:0030238)2.07950465
161paraxial mesoderm development (GO:0048339)2.07438083
162membrane repolarization (GO:0086009)2.07194080
163negative regulation of mRNA metabolic process (GO:1903312)2.07104517
164mRNA stabilization (GO:0048255)2.06958293
165RNA stabilization (GO:0043489)2.06958293
166histone H2A acetylation (GO:0043968)2.06916078
167regulation of dendritic spine morphogenesis (GO:0061001)2.06846072
168regulation of growth hormone secretion (GO:0060123)2.06652770
169actomyosin structure organization (GO:0031032)2.05959989
170regulation of glutamate receptor signaling pathway (GO:1900449)2.05183664
171mRNA polyadenylation (GO:0006378)2.04475628
172actin filament-based movement (GO:0030048)2.03654565
173regulation of calcium ion transmembrane transporter activity (GO:1901019)2.02410444
174regulation of calcium ion transmembrane transport (GO:1903169)2.02410444
175nuclear pore complex assembly (GO:0051292)2.02174947
176mitotic chromosome condensation (GO:0007076)2.01731078

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.89594060
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.87091198
3E2F7_22180533_ChIP-Seq_HELA_Human2.91266760
4KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.57612238
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.52552397
6ZNF274_21170338_ChIP-Seq_K562_Hela2.38649247
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38267769
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20646305
9HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.18736710
10FUS_26573619_Chip-Seq_HEK293_Human2.13576872
11GBX2_23144817_ChIP-Seq_PC3_Human2.11597212
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.04715717
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03138977
14* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01537554
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99494898
16JARID2_20064375_ChIP-Seq_MESCs_Mouse1.97288456
17EZH2_27304074_Chip-Seq_ESCs_Mouse1.96958983
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96311895
19TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.92220001
20CIITA_25753668_ChIP-Seq_RAJI_Human1.89808846
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80847955
22TP63_19390658_ChIP-ChIP_HaCaT_Human1.77467279
23RARB_27405468_Chip-Seq_BRAIN_Mouse1.73659362
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72434329
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66164744
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65905502
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65173074
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.65169061
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.64666021
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63459095
31* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.60379324
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.60163009
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60114394
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60055899
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59200950
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58758209
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.58314184
38XRN2_22483619_ChIP-Seq_HELA_Human1.58228444
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56958264
40EWS_26573619_Chip-Seq_HEK293_Human1.55183689
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54820923
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51894039
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51726843
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.48654895
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48044068
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48044068
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.47542892
48ELK1_19687146_ChIP-ChIP_HELA_Human1.46904487
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46868341
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45899163
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43436171
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42531312
53IGF1R_20145208_ChIP-Seq_DFB_Human1.41199108
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41161770
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38410430
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37137412
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36307580
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35983743
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35786602
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.35267572
61MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.34873769
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34755429
63* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33300030
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31923013
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31591369
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.30951133
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29343111
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.27621353
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25901886
70* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25881190
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25069738
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23854880
73SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.23738595
74REST_21632747_ChIP-Seq_MESCs_Mouse1.23288232
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21946059
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21936665
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21107248
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20761047
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20491974
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19486811
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17685977
82SOX2_21211035_ChIP-Seq_LN229_Gbm1.17203284
83SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16451490
84DCP1A_22483619_ChIP-Seq_HELA_Human1.15966866
85GABP_19822575_ChIP-Seq_HepG2_Human1.15347420
86REST_19997604_ChIP-ChIP_NEURONS_Mouse1.14843904
87EP300_21415370_ChIP-Seq_HL-1_Mouse1.13285089
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13115444
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13010688
90SMAD4_21799915_ChIP-Seq_A2780_Human1.12814404
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12172354
92ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11343484
93NANOG_21062744_ChIP-ChIP_HESCs_Human1.11292578
94EED_16625203_ChIP-ChIP_MESCs_Mouse1.11273972
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10847043
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10741342
97P300_19829295_ChIP-Seq_ESCs_Human1.10670754
98AR_21572438_ChIP-Seq_LNCaP_Human1.10605392
99ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09419429
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09296202
101DROSHA_22980978_ChIP-Seq_HELA_Human1.09227256
102AR_19668381_ChIP-Seq_PC3_Human1.08839707
103FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.08819943
104MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08685819
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07485245
106RNF2_27304074_Chip-Seq_NSC_Mouse1.07434616
107EZH2_27294783_Chip-Seq_ESCs_Mouse1.06859814
108ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05595494
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03649496
110CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03318518
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03280355
112SOX9_26525672_Chip-Seq_HEART_Mouse1.03228751
113* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03156522
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03015682
115GATA1_26923725_Chip-Seq_HPCs_Mouse1.01864442
116RING1B_27294783_Chip-Seq_NPCs_Mouse1.00438859
117WT1_19549856_ChIP-ChIP_CCG9911_Human1.00376433
118TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00361082
119SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99987345
120TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99951008
121NANOG_16153702_ChIP-ChIP_HESCs_Human0.99822880
122STAT3_23295773_ChIP-Seq_U87_Human0.99577328
123SOX17_20123909_ChIP-Seq_XEN_Mouse0.98066448
124TAF15_26573619_Chip-Seq_HEK293_Human0.97932097
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97544504
126POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97448472
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97269379
128REST_18959480_ChIP-ChIP_MESCs_Mouse0.96847382
129MYC_18940864_ChIP-ChIP_HL60_Human0.96727643
130VDR_23849224_ChIP-Seq_CD4+_Human0.95544650
131MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95165299
132PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94920711
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94555791
134SOX2_16153702_ChIP-ChIP_HESCs_Human0.94330020
135NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93898108
136BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93412937
137EGR1_19374776_ChIP-ChIP_THP-1_Human0.93355944
138KDM5A_27292631_Chip-Seq_BREAST_Human0.93220046
139AR_21909140_ChIP-Seq_LNCAP_Human0.92559752
140ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92523488
141MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92123791
142RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90135975
143E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89748547
144BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89730659
145THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89036798
146POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87191454
147TTF2_22483619_ChIP-Seq_HELA_Human0.86881536
148SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86812862
149SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85365453
150P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85022409
151ISL1_27105846_Chip-Seq_CPCs_Mouse0.84675183
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84574022
153SMAD3_21741376_ChIP-Seq_EPCs_Human0.84407771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio3.79815239
2MP0004084_abnormal_cardiac_muscle3.05537315
3MP0000751_myopathy2.82073455
4MP0003122_maternal_imprinting2.76213294
5MP0003121_genomic_imprinting2.53076806
6MP0002837_dystrophic_cardiac_calcinosis2.44074372
7MP0004859_abnormal_synaptic_plasticity2.44073948
8MP0003787_abnormal_imprinting2.41589579
9MP0004215_abnormal_myocardial_fiber2.34642209
10MP0004036_abnormal_muscle_relaxation2.34191821
11MP0003123_paternal_imprinting2.25171759
12MP0008058_abnormal_DNA_repair2.00165516
13MP0000749_muscle_degeneration1.89790569
14MP0008877_abnormal_DNA_methylation1.89562476
15MP0004233_abnormal_muscle_weight1.88269443
16MP0003693_abnormal_embryo_hatching1.81535497
17MP0003880_abnormal_central_pattern1.80106450
18MP0002234_abnormal_pharynx_morphology1.77071355
19MP0005187_abnormal_penis_morphology1.76727701
20MP0003646_muscle_fatigue1.74543817
21MP0005620_abnormal_muscle_contractility1.69802286
22MP0003137_abnormal_impulse_conducting1.67406112
23MP0002106_abnormal_muscle_physiology1.66003116
24MP0003635_abnormal_synaptic_transmissio1.65013050
25MP0008932_abnormal_embryonic_tissue1.63678830
26MP0006072_abnormal_retinal_apoptosis1.58322015
27MP0004270_analgesia1.56657686
28MP0001984_abnormal_olfaction1.55309433
29MP0004087_abnormal_muscle_fiber1.52050590
30MP0008789_abnormal_olfactory_epithelium1.47508241
31MP0005330_cardiomyopathy1.47071607
32MP0002063_abnormal_learning/memory/cond1.46877667
33MP0000747_muscle_weakness1.45029186
34MP0001299_abnormal_eye_distance/1.44013698
35MP0005499_abnormal_olfactory_system1.42311722
36MP0005394_taste/olfaction_phenotype1.42311722
37MP0005369_muscle_phenotype1.37275404
38MP0003221_abnormal_cardiomyocyte_apopto1.36460813
39MP0002184_abnormal_innervation1.36192786
40MP0003567_abnormal_fetal_cardiomyocyte1.35286361
41MP0002909_abnormal_adrenal_gland1.35157020
42MP0003937_abnormal_limbs/digits/tail_de1.33230402
43MP0001293_anophthalmia1.32718286
44MP0005248_abnormal_Harderian_gland1.31767006
45MP0000778_abnormal_nervous_system1.31554287
46MP0000013_abnormal_adipose_tissue1.29729445
47MP0002972_abnormal_cardiac_muscle1.27420547
48MP0004085_abnormal_heartbeat1.27139260
49MP0002697_abnormal_eye_size1.24854087
50MP0000759_abnormal_skeletal_muscle1.24794273
51MP0004484_altered_response_of1.24762251
52MP0002233_abnormal_nose_morphology1.24415523
53MP0003283_abnormal_digestive_organ1.22347724
54MP0008057_abnormal_DNA_replication1.21162079
55MP0005423_abnormal_somatic_nervous1.20444263
56MP0006292_abnormal_olfactory_placode1.18446713
57MP0002877_abnormal_melanocyte_morpholog1.17151921
58MP0003938_abnormal_ear_development1.15454746
59MP0006138_congestive_heart_failure1.13325503
60MP0002085_abnormal_embryonic_tissue1.12729920
61MP0009672_abnormal_birth_weight1.10640212
62MP0005551_abnormal_eye_electrophysiolog1.10598076
63MP0002734_abnormal_mechanical_nocicepti1.09883336
64MP0001188_hyperpigmentation1.09737743
65MP0002822_catalepsy1.09710496
66MP0002572_abnormal_emotion/affect_behav1.09100181
67MP0000631_abnormal_neuroendocrine_gland1.08482724
68MP0006276_abnormal_autonomic_nervous1.07980189
69MP0002210_abnormal_sex_determination1.07142415
70MP0004134_abnormal_chest_morphology1.04247965
71MP0002269_muscular_atrophy1.03985134
72MP0001286_abnormal_eye_development1.03907679
73MP0003385_abnormal_body_wall1.03353654
74MP0008995_early_reproductive_senescence1.02650469
75MP0000537_abnormal_urethra_morphology1.01557045
76MP0009745_abnormal_behavioral_response0.99839015
77MP0005380_embryogenesis_phenotype0.99542742
78MP0001672_abnormal_embryogenesis/_devel0.99542742
79MP0010630_abnormal_cardiac_muscle0.97989267
80MP0002084_abnormal_developmental_patter0.97194185
81MP0000428_abnormal_craniofacial_morphol0.95787180
82MP0002127_abnormal_cardiovascular_syste0.95367749
83MP0002557_abnormal_social/conspecific_i0.95113543
84MP0010094_abnormal_chromosome_stability0.95076751
85MP0002751_abnormal_autonomic_nervous0.94357018
86MP0000350_abnormal_cell_proliferation0.94230507
87MP0003119_abnormal_digestive_system0.92628529
88MP0010030_abnormal_orbit_morphology0.91827422
89MP0002272_abnormal_nervous_system0.91166989
90MP0000566_synostosis0.90826717
91MP0003942_abnormal_urinary_system0.90014812
92MP0009053_abnormal_anal_canal0.89972602
93MP0003890_abnormal_embryonic-extraembry0.89542234
94MP0002735_abnormal_chemical_nociception0.89109565
95MP0005385_cardiovascular_system_phenoty0.88107062
96MP0001544_abnormal_cardiovascular_syste0.88107062
97MP0001529_abnormal_vocalization0.87206227
98MP0009703_decreased_birth_body0.86985622
99MP0001727_abnormal_embryo_implantation0.86823524
100MP0004957_abnormal_blastocyst_morpholog0.86530569
101MP0003861_abnormal_nervous_system0.85532055
102MP0003984_embryonic_growth_retardation0.85372959
103MP0004185_abnormal_adipocyte_glucose0.85291723
104MP0004811_abnormal_neuron_physiology0.85125291
105MP0009250_abnormal_appendicular_skeleto0.83910424
106MP0000569_abnormal_digit_pigmentation0.83463778
107MP0003935_abnormal_craniofacial_develop0.83195176
108MP0002160_abnormal_reproductive_system0.82605211
109MP0004133_heterotaxia0.82292461
110MP0002088_abnormal_embryonic_growth/wei0.82249126
111MP0001440_abnormal_grooming_behavior0.82232687
112MP0002080_prenatal_lethality0.82076624
113MP0003111_abnormal_nucleus_morphology0.81804449
114MP0003755_abnormal_palate_morphology0.81295485
115MP0002064_seizures0.81253469
116MP0003115_abnormal_respiratory_system0.81085599
117MP0001730_embryonic_growth_arrest0.80163001
118MP0004885_abnormal_endolymph0.79732157
119MP0004197_abnormal_fetal_growth/weight/0.79558448
120MP0002152_abnormal_brain_morphology0.78949869
121MP0002638_abnormal_pupillary_reflex0.78743343
122MP0008569_lethality_at_weaning0.78581734
123MP0000049_abnormal_middle_ear0.78408107
124MP0001486_abnormal_startle_reflex0.77442584
125MP0002882_abnormal_neuron_morphology0.77101007
126MP0003315_abnormal_perineum_morphology0.77001511
127MP0005253_abnormal_eye_physiology0.76317219
128MP0008775_abnormal_heart_ventricle0.75608140
129MP0003077_abnormal_cell_cycle0.75164310
130MP0009780_abnormal_chondrocyte_physiolo0.74656560
131MP0002081_perinatal_lethality0.74293810
132MP0002116_abnormal_craniofacial_bone0.73933889
133MP0000955_abnormal_spinal_cord0.73495096
134MP0002067_abnormal_sensory_capabilities0.71969945
135MP0000266_abnormal_heart_morphology0.71490974
136MP0009384_cardiac_valve_regurgitation0.71282844
137MP0001697_abnormal_embryo_size0.71174926
138MP0005646_abnormal_pituitary_gland0.69882411
139MP0008007_abnormal_cellular_replicative0.69825890

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.00811332
2Muscle fiber inclusion bodies (HP:0100299)3.66665109
3Shoulder girdle muscle weakness (HP:0003547)3.60116393
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.55592860
5Exercise-induced muscle cramps (HP:0003710)3.42333596
6Cortical dysplasia (HP:0002539)3.41711782
7Nemaline bodies (HP:0003798)3.30417151
8Pelvic girdle muscle weakness (HP:0003749)3.18076454
9Calf muscle hypertrophy (HP:0008981)3.13643525
10Volvulus (HP:0002580)3.12185892
11Muscle hypertrophy of the lower extremities (HP:0008968)3.10837763
12Abnormality of the hip-girdle musculature (HP:0001445)3.05856453
13Abnormality of the musculature of the pelvis (HP:0001469)3.05856453
14Visual hallucinations (HP:0002367)2.95743328
15Rimmed vacuoles (HP:0003805)2.88963265
16Abnormality of the calf musculature (HP:0001430)2.78630198
17Type 1 muscle fiber predominance (HP:0003803)2.69894427
18Myopathic facies (HP:0002058)2.69808704
19Sudden death (HP:0001699)2.63326062
20Focal motor seizures (HP:0011153)2.42971808
21Central scotoma (HP:0000603)2.41604863
22Atrial fibrillation (HP:0005110)2.37087502
23Abnormality of the left ventricular outflow tract (HP:0011103)2.34558534
24Subaortic stenosis (HP:0001682)2.34558534
25Primary atrial arrhythmia (HP:0001692)2.34223890
26Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.30715792
27Abnormality of the lower motor neuron (HP:0002366)2.27026047
28Supraventricular tachycardia (HP:0004755)2.26091646
29High anterior hairline (HP:0009890)2.24565829
30Supraventricular arrhythmia (HP:0005115)2.24496378
31Difficulty running (HP:0009046)2.22624884
32EMG: myopathic abnormalities (HP:0003458)2.16278393
33Hypoplastic ischia (HP:0003175)2.16126274
34Colon cancer (HP:0003003)2.15868026
35Limb-girdle muscle weakness (HP:0003325)2.13781781
36Abnormality of the labia minora (HP:0012880)2.12799444
37Abnormality of alanine metabolism (HP:0010916)2.12614658
38Hyperalaninemia (HP:0003348)2.12614658
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12614658
40Insidious onset (HP:0003587)2.10899836
41Termporal pattern (HP:0011008)2.10899836
42Muscle fiber splitting (HP:0003555)2.07099456
43Limb-girdle muscle atrophy (HP:0003797)2.06954665
44Ulnar deviation of the wrist (HP:0003049)2.06519311
45Distal arthrogryposis (HP:0005684)2.06306311
46Scotoma (HP:0000575)2.05954509
47Abnormality of the corticospinal tract (HP:0002492)2.05702599
48Obsessive-compulsive behavior (HP:0000722)2.00786717
49Proximal amyotrophy (HP:0007126)1.98560668
50Progressive cerebellar ataxia (HP:0002073)1.96306717
51Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95341565
52Myoglobinuria (HP:0002913)1.94693012
53Broad palm (HP:0001169)1.94301643
54Papillary thyroid carcinoma (HP:0002895)1.93427148
55Broad-based gait (HP:0002136)1.92420868
56Congenital stationary night blindness (HP:0007642)1.90883824
57Genetic anticipation (HP:0003743)1.89035313
58Abnormality of the ischium (HP:0003174)1.83656084
59Gonadotropin excess (HP:0000837)1.82052485
60Prolonged QT interval (HP:0001657)1.81666473
61Urinary urgency (HP:0000012)1.81448275
62Chromsome breakage (HP:0040012)1.80739751
63Increased variability in muscle fiber diameter (HP:0003557)1.80071295
64Oligodactyly (HP:0012165)1.78224083
65Abnormality of the pubic bones (HP:0003172)1.78138574
66Abnormality of skeletal muscle fiber size (HP:0012084)1.77640553
67Obstructive sleep apnea (HP:0002870)1.77320144
68Pheochromocytoma (HP:0002666)1.77135912
69Oligodactyly (hands) (HP:0001180)1.74550707
70Myotonia (HP:0002486)1.72915062
71Overriding aorta (HP:0002623)1.72267794
72Chromosomal breakage induced by crosslinking agents (HP:0003221)1.71648518
73Ventricular tachycardia (HP:0004756)1.71491770
74Focal seizures (HP:0007359)1.68587698
75Drooling (HP:0002307)1.66619531
76Excessive salivation (HP:0003781)1.66619531
77Epileptic encephalopathy (HP:0200134)1.65562705
78Breech presentation (HP:0001623)1.65307842
79Hyporeflexia of lower limbs (HP:0002600)1.65275119
80Bundle branch block (HP:0011710)1.65066341
81Abnormal lung lobation (HP:0002101)1.64502838
82Vertebral arch anomaly (HP:0008438)1.64160708
83Depression (HP:0000716)1.64018851
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.63633748
85Degeneration of the lateral corticospinal tracts (HP:0002314)1.63633748
86Morphological abnormality of the middle ear (HP:0008609)1.63146412
87Truncal obesity (HP:0001956)1.63071652
88Neck muscle weakness (HP:0000467)1.62213816
89Long clavicles (HP:0000890)1.61409541
90Ankle clonus (HP:0011448)1.61216308
91Abnormality of the septum pellucidum (HP:0007375)1.61004318
92Amyotrophic lateral sclerosis (HP:0007354)1.59504548
93Abnormal hair whorl (HP:0010721)1.57922846
94Syncope (HP:0001279)1.56519626
95Absence seizures (HP:0002121)1.56338343
96Cystic hygroma (HP:0000476)1.56301334
97Insomnia (HP:0100785)1.55849214
98Limb dystonia (HP:0002451)1.55231745
99Left ventricular hypertrophy (HP:0001712)1.54999176
100Metaphyseal cupping (HP:0003021)1.54207688
101Calcaneovalgus deformity (HP:0001848)1.54157073
102Tented upper lip vermilion (HP:0010804)1.54094018
103Exostoses (HP:0100777)1.53787079
104Hyperacusis (HP:0010780)1.53577225
105Abnormal EKG (HP:0003115)1.52884268
106Fetal akinesia sequence (HP:0001989)1.52718621
107Abnormality of the shoulder girdle musculature (HP:0001435)1.52020927
108Macroorchidism (HP:0000053)1.51550851
109Progressive muscle weakness (HP:0003323)1.51381059
110Broad face (HP:0000283)1.50684244
111Renal duplication (HP:0000075)1.50625813
112Impaired vibration sensation in the lower limbs (HP:0002166)1.50387511
113Increased nuchal translucency (HP:0010880)1.49096411
114Proximal placement of thumb (HP:0009623)1.48794527
115Abnormality of chromosome segregation (HP:0002916)1.47807363
116Hepatoblastoma (HP:0002884)1.47728311
117Abnormality of the calcaneus (HP:0008364)1.47727902
118Medulloblastoma (HP:0002885)1.47250271
119Unsteady gait (HP:0002317)1.46471789
120Supernumerary spleens (HP:0009799)1.46145309
121Missing ribs (HP:0000921)1.45407892
122Aplasia/Hypoplasia of the sternum (HP:0006714)1.44579110
123Ependymoma (HP:0002888)1.44269218
124Short philtrum (HP:0000322)1.44160751
125Neuroendocrine neoplasm (HP:0100634)1.43193035
126Hyperventilation (HP:0002883)1.43120819
127Omphalocele (HP:0001539)1.42943110
128Mesomelia (HP:0003027)1.42848169
129Deformed tarsal bones (HP:0008119)1.42584729
130Increased serum pyruvate (HP:0003542)1.41779615
131Multiple enchondromatosis (HP:0005701)1.41717141
132Centrally nucleated skeletal muscle fibers (HP:0003687)1.41202422
133Generalized tonic-clonic seizures (HP:0002069)1.40589868
134Papilledema (HP:0001085)1.40588265
135Abnormality of the astrocytes (HP:0100707)1.40415844
136Astrocytoma (HP:0009592)1.40415844
137Poor eye contact (HP:0000817)1.39373776
138Partial agenesis of the corpus callosum (HP:0001338)1.39368175
139Gait imbalance (HP:0002141)1.39258436
140Postnatal microcephaly (HP:0005484)1.39254253
141Rhabdomyolysis (HP:0003201)1.39093086
142Tubulointerstitial nephritis (HP:0001970)1.38459838
143Meckel diverticulum (HP:0002245)1.38167017
144Hyperglycinemia (HP:0002154)1.37998233
145Horseshoe kidney (HP:0000085)1.37587709
146Narrow face (HP:0000275)1.37429025
147Abnormality of glycolysis (HP:0004366)1.37020768
148Sacral dimple (HP:0000960)1.36775931
149Overlapping toe (HP:0001845)1.35883751
150Unilateral renal agenesis (HP:0000122)1.35171403
151Progressive external ophthalmoplegia (HP:0000590)1.34950174
152Nephroblastoma (Wilms tumor) (HP:0002667)1.34736485
153Absent septum pellucidum (HP:0001331)1.34504206
154Retinal dysplasia (HP:0007973)1.33808316
155Elfin facies (HP:0004428)1.33619681
156Adducted thumb (HP:0001181)1.33235629
157Coarctation of aorta (HP:0001680)1.32028267
158Thyroid carcinoma (HP:0002890)1.31897254
159Webbed neck (HP:0000465)1.31696684

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K43.45404461
2OBSCN3.06058186
3MAP2K72.66782745
4NEK12.66232655
5NTRK32.65964425
6CDC72.42910890
7MARK12.35377127
8CASK2.28189535
9KSR12.27488442
10EPHA42.22110200
11RPS6KA42.13143016
12PHKG12.11599179
13PHKG22.11599179
14NME11.99615471
15MINK11.99431156
16PNCK1.97773250
17MAP2K41.93786588
18ERBB31.86137599
19TRIM281.84650011
20DMPK1.78126022
21PLK31.60347814
22TTN1.58570905
23PBK1.55366304
24WNK31.42772076
25PLK21.42484506
26NTRK11.40871464
27PLK41.35859274
28TYRO31.31498624
29CSNK1G21.30302322
30PAK31.26088422
31PKN21.25492300
32PIK3CG1.25130535
33CDK121.19717616
34EIF2AK11.18429144
35CDK191.15678444
36PAK61.12739701
37DYRK21.12186591
38MAP3K101.08280069
39MKNK11.08049370
40BUB11.07709083
41DYRK31.07226054
42GRK71.06121237
43CDK81.04856828
44FGFR21.03725512
45MAP3K71.03331571
46PINK11.02678108
47MAP3K90.99712819
48PRKD30.98364416
49ALK0.97559636
50CAMK1G0.93558906
51CSNK1G30.92436139
52CDK180.91996475
53CDK11A0.91341143
54TSSK60.91014138
55CDC42BPA0.90987432
56DYRK1A0.90721090
57SRPK10.88953498
58CDK140.88570550
59CDK150.87967923
60CSNK1G10.86307223
61MAPK130.85052524
62MKNK20.84877755
63VRK20.82672420
64PDGFRA0.82125819
65ATR0.81938580
66BRAF0.80841379
67* CSNK1E0.80371609
68STK38L0.78882263
69LATS10.78639457
70FGFR10.78633706
71NTRK20.78478650
72CSNK1A1L0.78142616
73ARAF0.77847641
74WEE10.77556678
75EPHB20.76968813
76UHMK10.74631040
77BRSK10.74402780
78CHEK10.73873825
79LIMK10.73873774
80SIK20.73788989
81DYRK1B0.73724187
82CCNB10.73498599
83AURKB0.73474207
84PASK0.72718171
85EEF2K0.72341535
86BCR0.72200418
87SCYL20.71239546
88TRIB30.70425975
89STK240.70127477
90RAF10.69559231
91CDK60.68757079
92CDK50.68588585
93YES10.68269506
94PLK10.66691035
95MOS0.66689969
96CDK10.66533404
97LATS20.65848009
98SIK30.65312532
99RPS6KB20.64308106
100FRK0.63970292
101WNK10.63177129
102CHEK20.62469180
103AURKA0.62319827
104NEK20.62032383
105CDK20.61148901
106PDK20.59961309
107MAPK100.59947821
108PRKDC0.59882176
109MUSK0.59205324
110CAMK2A0.58584564
111ATM0.57350843
112ILK0.57160677
113AKT20.56001668
114CAMK10.55810896
115GRK50.54933941
116GSK3B0.54703646
117PRKCG0.54037907
118PDK30.53748098
119PDK40.53748098
120SGK10.53541316
121STK380.52840242
122BRD40.52252822
123TNIK0.51758459
124TAOK20.51615145
125RPS6KA30.51092529
126TTK0.50769532
127CAMK2B0.50761965
128CDK30.50176450
129CDK70.49628786
130MAP3K50.49282684
131CAMK2D0.49069097
132PTK2B0.48088487
133RPS6KB10.47909335
134ACVR1B0.47108384
135FER0.46700973
136MAPK140.46346861
137TAF10.46128007
138CDK90.44922324
139CSNK2A20.44892864
140PRKACB0.44843658
141PRKG10.43358138

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.26952685
2Long-term potentiation_Homo sapiens_hsa047202.00921291
3Non-homologous end-joining_Homo sapiens_hsa034502.00104642
4Olfactory transduction_Homo sapiens_hsa047401.98297691
5Cardiac muscle contraction_Homo sapiens_hsa042601.85548529
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82288957
7Dilated cardiomyopathy_Homo sapiens_hsa054141.81476929
8Circadian entrainment_Homo sapiens_hsa047131.81473829
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78225468
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.76121626
11Dopaminergic synapse_Homo sapiens_hsa047281.75396665
12Protein export_Homo sapiens_hsa030601.74996603
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73857664
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.70824050
15GABAergic synapse_Homo sapiens_hsa047271.67748437
16Spliceosome_Homo sapiens_hsa030401.66788238
17Oxytocin signaling pathway_Homo sapiens_hsa049211.61597531
18Amphetamine addiction_Homo sapiens_hsa050311.60797748
19Oocyte meiosis_Homo sapiens_hsa041141.59414447
20Phototransduction_Homo sapiens_hsa047441.59096303
21Morphine addiction_Homo sapiens_hsa050321.58031912
22RNA transport_Homo sapiens_hsa030131.54957352
23Insulin secretion_Homo sapiens_hsa049111.53157956
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52387260
25mRNA surveillance pathway_Homo sapiens_hsa030151.52319836
26cGMP-PKG signaling pathway_Homo sapiens_hsa040221.51409562
27Propanoate metabolism_Homo sapiens_hsa006401.50730250
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48990360
29Glutamatergic synapse_Homo sapiens_hsa047241.47157224
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47121847
31Renin secretion_Homo sapiens_hsa049241.39339671
32Calcium signaling pathway_Homo sapiens_hsa040201.36553115
33Proteasome_Homo sapiens_hsa030501.34330683
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29027103
35Cholinergic synapse_Homo sapiens_hsa047251.26700594
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.26231814
37Taste transduction_Homo sapiens_hsa047421.25474836
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24888679
39DNA replication_Homo sapiens_hsa030301.24621023
40Carbon metabolism_Homo sapiens_hsa012001.24532722
41RNA degradation_Homo sapiens_hsa030181.23500250
42Cell cycle_Homo sapiens_hsa041101.20216469
43Long-term depression_Homo sapiens_hsa047301.19702491
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18438703
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17543561
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16521874
47Pyruvate metabolism_Homo sapiens_hsa006201.16498104
48Biosynthesis of amino acids_Homo sapiens_hsa012301.15349922
49Wnt signaling pathway_Homo sapiens_hsa043101.15021733
50cAMP signaling pathway_Homo sapiens_hsa040241.14407316
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12593617
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12098275
53Mismatch repair_Homo sapiens_hsa034301.10793799
54Gap junction_Homo sapiens_hsa045401.07405767
55Glucagon signaling pathway_Homo sapiens_hsa049221.03997549
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03823634
57Serotonergic synapse_Homo sapiens_hsa047261.02672820
58Circadian rhythm_Homo sapiens_hsa047101.02578687
59Axon guidance_Homo sapiens_hsa043601.01675945
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00287759
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99434733
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99274707
63Homologous recombination_Homo sapiens_hsa034400.98476645
64Folate biosynthesis_Homo sapiens_hsa007900.98225196
65Salivary secretion_Homo sapiens_hsa049700.98084538
66Oxidative phosphorylation_Homo sapiens_hsa001900.97078314
67GnRH signaling pathway_Homo sapiens_hsa049120.96998601
68Glioma_Homo sapiens_hsa052140.94423821
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94130361
70Gastric acid secretion_Homo sapiens_hsa049710.93979040
71Estrogen signaling pathway_Homo sapiens_hsa049150.93925400
72Melanogenesis_Homo sapiens_hsa049160.93214368
73RNA polymerase_Homo sapiens_hsa030200.92582704
74Colorectal cancer_Homo sapiens_hsa052100.90900111
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90394027
76Endometrial cancer_Homo sapiens_hsa052130.89362928
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87638622
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87115927
79Cocaine addiction_Homo sapiens_hsa050300.87022996
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85249713
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.83936294
82Hippo signaling pathway_Homo sapiens_hsa043900.83804452
83Synaptic vesicle cycle_Homo sapiens_hsa047210.83249977
84Type II diabetes mellitus_Homo sapiens_hsa049300.82771761
85Butanoate metabolism_Homo sapiens_hsa006500.77846878
86Insulin signaling pathway_Homo sapiens_hsa049100.76958205
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76911552
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.76316046
89Nucleotide excision repair_Homo sapiens_hsa034200.75860554
90mTOR signaling pathway_Homo sapiens_hsa041500.74349371
91VEGF signaling pathway_Homo sapiens_hsa043700.73216404
92Hedgehog signaling pathway_Homo sapiens_hsa043400.72675319
93Base excision repair_Homo sapiens_hsa034100.71934464
94Basal cell carcinoma_Homo sapiens_hsa052170.70691104
95Tight junction_Homo sapiens_hsa045300.70681839
96Parkinsons disease_Homo sapiens_hsa050120.69604141
97Dorso-ventral axis formation_Homo sapiens_hsa043200.69419718
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69409671
99Choline metabolism in cancer_Homo sapiens_hsa052310.69383684
100Non-small cell lung cancer_Homo sapiens_hsa052230.68019846
101Focal adhesion_Homo sapiens_hsa045100.67321100
102Ribosome_Homo sapiens_hsa030100.66854283
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66772661
104Alzheimers disease_Homo sapiens_hsa050100.66430810
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.66069934
106Pancreatic secretion_Homo sapiens_hsa049720.65881976
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64156371
108Renal cell carcinoma_Homo sapiens_hsa052110.64057264
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63282351
110ErbB signaling pathway_Homo sapiens_hsa040120.61866940
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61526423
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61389680
113Huntingtons disease_Homo sapiens_hsa050160.61351904
114Adherens junction_Homo sapiens_hsa045200.60811958
115MAPK signaling pathway_Homo sapiens_hsa040100.60420518
116Alcoholism_Homo sapiens_hsa050340.60221505
117Fatty acid elongation_Homo sapiens_hsa000620.58762675
118One carbon pool by folate_Homo sapiens_hsa006700.58697558
119Pyrimidine metabolism_Homo sapiens_hsa002400.57928119
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57511618
121Basal transcription factors_Homo sapiens_hsa030220.56762343
122Thyroid cancer_Homo sapiens_hsa052160.56529052
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.55271798
124Lysine degradation_Homo sapiens_hsa003100.55122731
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54873059
126Purine metabolism_Homo sapiens_hsa002300.54135316
127beta-Alanine metabolism_Homo sapiens_hsa004100.53443186
128Fanconi anemia pathway_Homo sapiens_hsa034600.52381502
129Steroid biosynthesis_Homo sapiens_hsa001000.51600415
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51394455
131Pentose phosphate pathway_Homo sapiens_hsa000300.50926685
132Selenocompound metabolism_Homo sapiens_hsa004500.50888854
133FoxO signaling pathway_Homo sapiens_hsa040680.50279218
134AMPK signaling pathway_Homo sapiens_hsa041520.50262437
135MicroRNAs in cancer_Homo sapiens_hsa052060.49996952
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48236183
137Arginine and proline metabolism_Homo sapiens_hsa003300.47905065

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