HTATSF1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.41504117
2positive regulation of mast cell activation (GO:0033005)4.40767984
3response to peptidoglycan (GO:0032494)4.36186542
4granulocyte activation (GO:0036230)4.07285476
5positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.05162692
6neutrophil activation (GO:0042119)4.03014467
7regulation of platelet aggregation (GO:0090330)3.97358971
8cellular extravasation (GO:0045123)3.96424039
9lipopolysaccharide-mediated signaling pathway (GO:0031663)3.92225769
10positive regulation of cellular amide metabolic process (GO:0034250)3.87010604
11regulation of mast cell degranulation (GO:0043304)3.83817810
12regulation of platelet activation (GO:0010543)3.76874312
13adenosine receptor signaling pathway (GO:0001973)3.73469753
14cellular response to thyroid hormone stimulus (GO:0097067)3.73074558
15positive regulation of macrophage differentiation (GO:0045651)3.63855212
16positive regulation of gamma-delta T cell activation (GO:0046645)3.61957129
17detection of molecule of bacterial origin (GO:0032490)3.56408327
18leukocyte migration involved in inflammatory response (GO:0002523)3.55124721
19regulation of mast cell activation involved in immune response (GO:0033006)3.54326625
20thrombin receptor signaling pathway (GO:0070493)3.49708672
21positive regulation of mast cell activation involved in immune response (GO:0033008)3.48389083
22positive regulation of mast cell degranulation (GO:0043306)3.48389083
23negative regulation of erythrocyte differentiation (GO:0045647)3.47332261
24regulation of mast cell activation (GO:0033003)3.41352108
25positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.39890871
26negative regulation of interleukin-12 production (GO:0032695)3.38385516
27protein neddylation (GO:0045116)3.37835924
28platelet aggregation (GO:0070527)3.33555924
29regulation of neuron projection regeneration (GO:0070570)3.33285740
30regulation of axon regeneration (GO:0048679)3.33285740
31germinal center formation (GO:0002467)3.26514458
32regulation of leukocyte degranulation (GO:0043300)3.20055143
33positive regulation of leukocyte degranulation (GO:0043302)3.18355004
34glycosphingolipid catabolic process (GO:0046479)3.15276148
35leukocyte degranulation (GO:0043299)3.14251112
36regulation of integrin activation (GO:0033623)3.13744187
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.12882740
38positive regulation by organism of defense response of other organism involved in symbiotic interact3.12882740
39modulation by symbiont of host immune response (GO:0052553)3.12882740
40positive regulation by symbiont of host defense response (GO:0052509)3.12882740
41modulation by symbiont of host defense response (GO:0052031)3.12882740
42modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.12882740
43response to thyroid hormone (GO:0097066)3.11519851
44myeloid cell activation involved in immune response (GO:0002275)3.10736960
45negative regulation of homotypic cell-cell adhesion (GO:0034111)3.07920609
46positive regulation of receptor recycling (GO:0001921)3.04081490
47oligosaccharide catabolic process (GO:0009313)3.00806569
48negative regulation of protein localization to plasma membrane (GO:1903077)3.00791756
49regulation of interferon-beta biosynthetic process (GO:0045357)3.00330311
50regulation of integrin-mediated signaling pathway (GO:2001044)3.00138053
51macrophage activation involved in immune response (GO:0002281)2.97800930
52regulation of vitamin D biosynthetic process (GO:0060556)2.97474498
53negative regulation of interleukin-17 production (GO:0032700)2.97180287
54regulation of transmission of nerve impulse (GO:0051969)2.95974831
55regulation of myeloid leukocyte mediated immunity (GO:0002886)2.95582150
56regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.92390368
57negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.88833147
58protein localization to endosome (GO:0036010)2.86991807
59regulation of T-helper 2 cell differentiation (GO:0045628)2.84786081
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.81068608
61lipoxygenase pathway (GO:0019372)2.80245367
62regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.79637329
63Arp2/3 complex-mediated actin nucleation (GO:0034314)2.78429880
64negative regulation of platelet activation (GO:0010544)2.76503695
65glycolipid catabolic process (GO:0019377)2.75440325
66positive regulation of toll-like receptor signaling pathway (GO:0034123)2.74609031
67positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.73493180
68hepatocyte apoptotic process (GO:0097284)2.73009891
69platelet degranulation (GO:0002576)2.72507185
70megakaryocyte development (GO:0035855)2.70604002
71positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.70285340
72regulation of homotypic cell-cell adhesion (GO:0034110)2.68689100
73positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.67369603
74hypotonic response (GO:0006971)2.66533094
75detection of other organism (GO:0098543)2.66200064
76regulation of early endosome to late endosome transport (GO:2000641)2.64287109
77detection of external biotic stimulus (GO:0098581)2.63878559
78positive regulation of interleukin-6 production (GO:0032755)2.63678149
79positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.63160561
80G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.62682594
81platelet formation (GO:0030220)2.60626493
82cellular response to arsenic-containing substance (GO:0071243)2.59628457
83leukocyte aggregation (GO:0070486)2.58757003
84positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.55476575
85iron ion import (GO:0097286)2.53681356
86positive regulation of B cell differentiation (GO:0045579)2.53448084
87regulation of interleukin-17 production (GO:0032660)2.53433449
88G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.52305118
89negative regulation of stress fiber assembly (GO:0051497)2.52071256
90homotypic cell-cell adhesion (GO:0034109)2.50911194
91mesodermal cell differentiation (GO:0048333)2.50236639
92positive regulation of hemostasis (GO:1900048)2.49109110
93positive regulation of blood coagulation (GO:0030194)2.49109110
94negative regulation of lipid storage (GO:0010888)2.47727920
95immunoglobulin mediated immune response (GO:0016064)2.46084871
96cellular response to molecule of bacterial origin (GO:0071219)2.42512773
97positive regulation of tumor necrosis factor production (GO:0032760)2.40665191
98phagocytosis, engulfment (GO:0006911)2.40579919
99cellular response to lipopolysaccharide (GO:0071222)2.40540566
100platelet activation (GO:0030168)2.39325350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.56848421
2MYB_21317192_ChIP-Seq_ERMYB_Mouse3.41864512
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.38414958
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.20664920
5NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.18028964
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.06072953
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.00942520
8SPI1_23127762_ChIP-Seq_K562_Human2.78661473
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.70094245
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.69285563
11SCL_19346495_ChIP-Seq_HPC-7_Human2.67490931
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.60914950
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.57579918
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.53509977
15GATA1_19941826_ChIP-Seq_K562_Human2.48270281
16GATA1_22025678_ChIP-Seq_K562_Human2.47002959
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.36336612
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32264195
19SPI1_23547873_ChIP-Seq_NB4_Human2.29213664
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.21805438
21SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.19080146
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.12560001
23GATA2_19941826_ChIP-Seq_K562_Human2.11956427
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.10305775
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.06915282
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.05922503
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05127228
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.03866599
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.99776594
30TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.99656385
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.96566926
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.94004841
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.89743264
34NCOR1_26117541_ChIP-Seq_K562_Human1.86227267
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.86108304
36GATA1_19941827_ChIP-Seq_MEL_Mouse1.83805235
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.82202389
38GATA1_22383799_ChIP-Seq_G1ME_Mouse1.80828029
39VDR_24763502_ChIP-Seq_THP-1_Human1.79296482
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77325144
41GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.72157795
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69869063
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.65653903
44GATA2_22383799_ChIP-Seq_G1ME_Mouse1.65422829
45MYC_22102868_ChIP-Seq_BL_Human1.62573079
46RUNX_20019798_ChIP-Seq_JUKART_Human1.61681446
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57800290
48MAF_26560356_Chip-Seq_TH1_Human1.55133095
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54830064
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.54445429
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49221139
52MYB_26560356_Chip-Seq_TH2_Human1.47963215
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47521693
54PU_27001747_Chip-Seq_BMDM_Mouse1.45237340
55TFEB_21752829_ChIP-Seq_HELA_Human1.44267186
56GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.42497901
57VDR_24787735_ChIP-Seq_THP-1_Human1.39842679
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37630584
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37451686
60UTX_26944678_Chip-Seq_JUKART_Human1.36059868
61VDR_21846776_ChIP-Seq_THP-1_Human1.35533108
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34707533
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34008537
64MYB_26560356_Chip-Seq_TH1_Human1.33777587
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.33130932
66ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.32674346
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29356615
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28766899
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25490988
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24860681
71TCF7_22412390_ChIP-Seq_EML_Mouse1.21915719
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21667569
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17820390
74EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14998978
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14219191
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13951977
77FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13866724
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13162300
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.13109943
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12424082
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11593767
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10011890
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07689079
84SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07689079
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07100682
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06896055
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05661854
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05408732
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04466428
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04112015
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02221793
92FOXM1_23109430_ChIP-Seq_U2OS_Human1.02150006
93PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99247732
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98706308
95JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98050481
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97731493
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96421985
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94483783
99GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93394551
100E2F7_22180533_ChIP-Seq_HELA_Human0.92529058

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology4.82319035
2MP0002877_abnormal_melanocyte_morpholog3.54659557
3MP0003724_increased_susceptibility_to3.51129128
4MP0003303_peritoneal_inflammation3.44614251
5MP0003436_decreased_susceptibility_to2.86556708
6MP0000343_altered_response_to2.70684448
7MP0005058_abnormal_lysosome_morphology2.66731562
8MP0005451_abnormal_body_composition2.61703225
9MP0001835_abnormal_antigen_presentation2.59651946
10MP0003191_abnormal_cellular_cholesterol2.52759958
11MP0002148_abnormal_hypersensitivity_rea2.48451549
12MP0008004_abnormal_stomach_pH2.27485039
13MP0002419_abnormal_innate_immunity2.23399741
14MP0004510_myositis2.18184536
15MP0003656_abnormal_erythrocyte_physiolo2.05831693
16MP0005000_abnormal_immune_tolerance2.04478946
17MP0003300_gastrointestinal_ulcer1.97897153
18MP0000858_altered_metastatic_potential1.97584738
19MP0009840_abnormal_foam_cell1.92084561
20MP0009278_abnormal_bone_marrow1.90856515
21MP0005397_hematopoietic_system_phenotyp1.81762011
22MP0001545_abnormal_hematopoietic_system1.81762011
23MP0003566_abnormal_cell_adhesion1.81418682
24MP0003828_pulmonary_edema1.80948707
25MP0002452_abnormal_antigen_presenting1.70894220
26MP0005025_abnormal_response_to1.70682630
27MP0001533_abnormal_skeleton_physiology1.70275490
28MP0004947_skin_inflammation1.69790179
29MP0009785_altered_susceptibility_to1.67726740
30MP0009764_decreased_sensitivity_to1.66252977
31MP0002723_abnormal_immune_serum1.65019442
32MP0003172_abnormal_lysosome_physiology1.62041647
33MP0002332_abnormal_exercise_endurance1.50515717
34MP0005171_absent_coat_pigmentation1.50167261
35MP0005387_immune_system_phenotype1.50086737
36MP0001790_abnormal_immune_system1.50086737
37MP0003950_abnormal_plasma_membrane1.49213407
38MP0003075_altered_response_to1.48166449
39MP0002420_abnormal_adaptive_immunity1.43423275
40MP0001819_abnormal_immune_cell1.42275940
41MP0005671_abnormal_response_to1.41616093
42MP0001800_abnormal_humoral_immune1.39274916
43MP0002998_abnormal_bone_remodeling1.37162093
44MP0001845_abnormal_inflammatory_respons1.36426505
45MP0003448_altered_tumor_morphology1.34073992
46MP0002398_abnormal_bone_marrow1.32946498
47MP0009333_abnormal_splenocyte_physiolog1.32556814
48MP0000685_abnormal_immune_system1.32330861
49MP0000015_abnormal_ear_pigmentation1.30664959
50MP0005164_abnormal_response_to1.28368049
51MP0005167_abnormal_blood-brain_barrier1.28073524
52MP0006082_CNS_inflammation1.24356860
53MP0003705_abnormal_hypodermis_morpholog1.23102795
54MP0008260_abnormal_autophagy1.23042470
55MP0010155_abnormal_intestine_physiology1.22846530
56MP0000465_gastrointestinal_hemorrhage1.18176049
57MP0009763_increased_sensitivity_to1.17855133
58MP0002405_respiratory_system_inflammati1.13855684
59MP0000716_abnormal_immune_system1.09714770
60MP0002429_abnormal_blood_cell1.08692626
61MP0004782_abnormal_surfactant_physiolog1.08547707
62MP0010352_gastrointestinal_tract_polyps1.08013619
63MP0005408_hypopigmentation1.06914421
64MP0004808_abnormal_hematopoietic_stem1.06166040
65MP0002132_abnormal_respiratory_system1.06080374
66MP0003091_abnormal_cell_migration1.05765547
67MP0000249_abnormal_blood_vessel1.05160717
68MP0000689_abnormal_spleen_morphology1.04228994
69MP0008469_abnormal_protein_level1.03795396
70MP0002722_abnormal_immune_system1.03588208
71MP0003453_abnormal_keratinocyte_physiol1.02883391
72MP0003806_abnormal_nucleotide_metabolis1.02477771
73MP0004130_abnormal_muscle_cell1.00077541
74MP0005166_decreased_susceptibility_to0.96400198
75MP0001853_heart_inflammation0.95893727
76MP0002006_tumorigenesis0.94079268
77MP0005023_abnormal_wound_healing0.88317944
78MP0004036_abnormal_muscle_relaxation0.85189547
79MP0000569_abnormal_digit_pigmentation0.84045155
80MP0005165_increased_susceptibility_to0.82784719
81MP0000749_muscle_degeneration0.82003752
82MP0006054_spinal_hemorrhage0.81226579
83MP0005174_abnormal_tail_pigmentation0.80992030
84MP0004883_abnormal_blood_vessel0.79916997
85MP0004381_abnormal_hair_follicle0.78652055
86MP0004084_abnormal_cardiac_muscle0.77668502
87MP0005666_abnormal_adipose_tissue0.77392846
88MP0003795_abnormal_bone_structure0.75895619
89MP0002166_altered_tumor_susceptibility0.75315978
90MP0000604_amyloidosis0.74872417
91MP0001851_eye_inflammation0.74546382
92MP0005083_abnormal_biliary_tract0.73838581
93MP0003045_fibrosis0.70204787
94MP0005621_abnormal_cell_physiology0.70126709
95MP0008438_abnormal_cutaneous_collagen0.68816704
96MP0000358_abnormal_cell_content/0.68776717
97MP0003221_abnormal_cardiomyocyte_apopto0.68489059
98MP0009765_abnormal_xenobiotic_induced0.68284376
99MP0003763_abnormal_thymus_physiology0.67809775
100MP0000371_diluted_coat_color0.67429675

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)5.89120602
2Increased mean platelet volume (HP:0011877)5.55779045
3Abnormal platelet volume (HP:0011876)5.40076662
4Petechiae (HP:0000967)5.16792931
5Menorrhagia (HP:0000132)5.13030969
6Purpura (HP:0000979)4.52583781
7Epistaxis (HP:0000421)4.48079818
8Abnormality of macrophages (HP:0004311)4.46376084
9Myocardial infarction (HP:0001658)3.90766768
10Abnormal platelet function (HP:0011869)3.85610498
11Impaired platelet aggregation (HP:0003540)3.85610498
12Gingival bleeding (HP:0000225)3.70956789
13Eczematoid dermatitis (HP:0000976)3.52491280
14Recurrent bacterial skin infections (HP:0005406)3.36117013
15Abnormality of liposaccharide metabolism (HP:0010968)3.33509548
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.33509548
17Abnormality of glycolipid metabolism (HP:0010969)3.33509548
18Recurrent abscess formation (HP:0002722)3.33067221
19Spontaneous hematomas (HP:0007420)3.10518450
20Vacuolated lymphocytes (HP:0001922)2.95566157
21Hepatosplenomegaly (HP:0001433)2.88746845
22Polycythemia (HP:0001901)2.87149386
23Upper limb muscle weakness (HP:0003484)2.86626973
24Dysostosis multiplex (HP:0000943)2.74272917
25Abnormality of the common coagulation pathway (HP:0010990)2.71073512
26Distal lower limb amyotrophy (HP:0008944)2.65018640
27Obstructive lung disease (HP:0006536)2.61769405
28Chronic obstructive pulmonary disease (HP:0006510)2.61769405
29Abnormality of the vasculature of the conjunctiva (HP:0008054)2.59583707
30Stomatitis (HP:0010280)2.58580068
31Fatigue (HP:0012378)2.56471556
32Recurrent gram-negative bacterial infections (HP:0005420)2.45899243
33Increased serum ferritin (HP:0003281)2.44944648
34Conjunctival telangiectasia (HP:0000524)2.44424201
35Orchitis (HP:0100796)2.44387515
36Abnormal gallbladder physiology (HP:0012438)2.43598295
37Cholecystitis (HP:0001082)2.43598295
38Arterial thrombosis (HP:0004420)2.43267574
39Increased cerebral lipofuscin (HP:0011813)2.37848234
40Retrobulbar optic neuritis (HP:0100654)2.37356502
41Optic neuritis (HP:0100653)2.37356502
42Episodic fever (HP:0001954)2.36018476
43Paralysis (HP:0003470)2.34614857
44Abnormality of the sella turcica (HP:0002679)2.34037007
45Loss of speech (HP:0002371)2.23460792
46Abnormality of iron homeostasis (HP:0011031)2.21496077
47Hyperlipoproteinemia (HP:0010980)2.19317015
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.18389069
49Osteolytic defects of the hand bones (HP:0009699)2.18389069
50Increased connective tissue (HP:0009025)2.17110183
51Bruising susceptibility (HP:0000978)2.17022272
52Myositis (HP:0100614)2.12987933
53Nausea (HP:0002018)2.03969930
54Hypertensive crisis (HP:0100735)2.03252624
55Male infertility (HP:0003251)2.03180991
56Recurrent skin infections (HP:0001581)2.02227486
57Thick nail (HP:0001805)1.98206132
58Abnormality of the heme biosynthetic pathway (HP:0010472)1.97771702
59Poikilocytosis (HP:0004447)1.96478999
60Orthostatic hypotension (HP:0001278)1.95359294
61Amyloidosis (HP:0011034)1.94479978
62Distal lower limb muscle weakness (HP:0009053)1.93807870
63Nemaline bodies (HP:0003798)1.92837479
64Tinnitus (HP:0000360)1.91549721
65Mucosal telangiectasiae (HP:0100579)1.90919497
66Albinism (HP:0001022)1.90114587
67Ventricular fibrillation (HP:0001663)1.88431308
68Recurrent fungal infections (HP:0002841)1.87155949
69Encephalitis (HP:0002383)1.87024384
70Lower limb amyotrophy (HP:0007210)1.86478124
71Keratoconjunctivitis sicca (HP:0001097)1.85608042
72Anorexia (HP:0002039)1.82903717
73Thrombocytosis (HP:0001894)1.82766231
74Urticaria (HP:0001025)1.80893231
75Chest pain (HP:0100749)1.80799735
76Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.79916710
77Recurrent viral infections (HP:0004429)1.79466083
78Abnormality of skeletal muscle fiber size (HP:0012084)1.78383215
79Subacute progressive viral hepatitis (HP:0006572)1.77606789
80Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.76909057
81Abnormality of the Achilles tendon (HP:0005109)1.76260783
82Autoimmune hemolytic anemia (HP:0001890)1.75244652
83Acanthocytosis (HP:0001927)1.73905272
84Muscle fiber inclusion bodies (HP:0100299)1.73731888
85Hypertriglyceridemia (HP:0002155)1.73635874
86Amaurosis fugax (HP:0100576)1.71065050
87Mediastinal lymphadenopathy (HP:0100721)1.70906236
88Elevated erythrocyte sedimentation rate (HP:0003565)1.70595034
89Tetraparesis (HP:0002273)1.70446854
90Abnormal pupillary function (HP:0007686)1.69403610
91Joint swelling (HP:0001386)1.69091996
92Mitral stenosis (HP:0001718)1.69029292
93Increased neuronal autofluorescent lipopigment (HP:0002074)1.68955928
94Abnormality of transition element cation homeostasis (HP:0011030)1.68691796
95Xanthomatosis (HP:0000991)1.68430141
96Gingivitis (HP:0000230)1.68411910
97Increased IgM level (HP:0003496)1.67426715
98Cellulitis (HP:0100658)1.66486443
99Glomerulopathy (HP:0100820)1.64571491
100Viral hepatitis (HP:0006562)1.63666779

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.44476409
2RIPK45.27716596
3BMPR22.81735124
4MAP2K32.36255367
5BLK2.20866691
6ZAP702.18947914
7ERBB42.18010455
8MAP3K142.13489434
9BMX2.09299221
10MST42.06335867
11IRAK42.05612778
12TAOK21.88582027
13TAOK31.88403569
14PIK3CG1.88063814
15PRPF4B1.87872219
16CSK1.73513287
17MAP3K31.71186215
18CLK11.69345921
19TTN1.64330036
20EIF2AK11.62182793
21BTK1.61691497
22SIK31.46557740
23IRAK21.39783177
24MATK1.39076766
25TESK21.38649754
26FGR1.35557395
27EPHB11.33562425
28MARK31.32848231
29TYK21.29028821
30KSR21.27641151
31TXK1.22426512
32TEC1.21935883
33HCK1.19335984
34IKBKB1.17419010
35SYK1.16336427
36IRAK11.15234262
37MYLK1.13562387
38JAK31.02912303
39LYN1.02652195
40PTK2B1.00703234
41RAF11.00519410
42TBK10.98774763
43JAK20.97065732
44ERN10.96643218
45PAK10.95074383
46SCYL20.94673969
47PBK0.94177276
48CSF1R0.92875041
49YES10.92774092
50NME20.92566969
51STK100.90635751
52ILK0.86326938
53PIM20.85238708
54JAK10.84592884
55MOS0.84113290
56PAK40.83248623
57MAP3K10.82662270
58STK30.81692475
59MAP3K20.76459522
60DDR20.76243101
61FER0.74600581
62ARAF0.73578395
63GRK70.71318344
64TRPM70.67095980
65KSR10.64591710
66PDK20.62681162
67STK240.61224272
68MAP4K10.60910086
69MAP3K50.60365202
70FES0.58130281
71MAP3K130.57807471
72MAP3K80.57604612
73MAP2K10.56905038
74PDPK10.55109577
75MAP3K60.54685404
76RET0.53160545
77PDGFRB0.51107227
78TGFBR20.50363522
79GRK60.50281457
80TAOK10.48439400
81NEK90.48202832
82PLK20.46901139
83CDK60.45922884
84MAPKAPK30.45724252
85CDC42BPA0.44178681
86TESK10.43824854
87PDK10.40606763
88LCK0.39386860
89MAPKAPK20.39153256
90ICK0.38863501
91IKBKE0.38719113
92GSK3A0.38110803
93PRKD10.37179717
94SIK10.36724173
95STK40.35196253
96MAPK120.35038052
97ABL10.33076562
98TRIB30.32487423
99TRIM280.30313365
100BRSK20.29344140

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.95126020
2Osteoclast differentiation_Homo sapiens_hsa043802.41663129
3Platelet activation_Homo sapiens_hsa046112.38568478
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.32678782
5Other glycan degradation_Homo sapiens_hsa005112.28345952
6Leishmaniasis_Homo sapiens_hsa051402.25175884
7Legionellosis_Homo sapiens_hsa051342.10229294
8Lysosome_Homo sapiens_hsa041421.94678856
9Hematopoietic cell lineage_Homo sapiens_hsa046401.94156338
10Shigellosis_Homo sapiens_hsa051311.90569835
11B cell receptor signaling pathway_Homo sapiens_hsa046621.90142520
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.89033259
13Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.88947464
14Malaria_Homo sapiens_hsa051441.81015831
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.79218543
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74949421
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.73077217
18Tuberculosis_Homo sapiens_hsa051521.71034991
19Acute myeloid leukemia_Homo sapiens_hsa052211.53880131
20Pancreatic cancer_Homo sapiens_hsa052121.52640768
21Salmonella infection_Homo sapiens_hsa051321.51137049
22Staphylococcus aureus infection_Homo sapiens_hsa051501.50298833
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.49944844
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49926020
25Chronic myeloid leukemia_Homo sapiens_hsa052201.48844339
26Phagosome_Homo sapiens_hsa041451.47623926
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45773934
28TNF signaling pathway_Homo sapiens_hsa046681.45608384
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.42010745
30Chemokine signaling pathway_Homo sapiens_hsa040621.40968829
31Toxoplasmosis_Homo sapiens_hsa051451.37088466
32Non-small cell lung cancer_Homo sapiens_hsa052231.36018401
33Rheumatoid arthritis_Homo sapiens_hsa053231.34339423
34Pertussis_Homo sapiens_hsa051331.32190340
35Bladder cancer_Homo sapiens_hsa052191.31572592
36Influenza A_Homo sapiens_hsa051641.27092123
37Measles_Homo sapiens_hsa051621.26320739
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25743191
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23640599
40Hepatitis B_Homo sapiens_hsa051611.22248208
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17435078
42Apoptosis_Homo sapiens_hsa042101.16753508
43Renal cell carcinoma_Homo sapiens_hsa052111.14757145
44Pentose phosphate pathway_Homo sapiens_hsa000301.13631182
45VEGF signaling pathway_Homo sapiens_hsa043701.12032830
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.10371073
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09829404
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03619229
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03021663
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96878216
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96219825
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.95820090
53HIF-1 signaling pathway_Homo sapiens_hsa040660.95240336
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.95125041
55Galactose metabolism_Homo sapiens_hsa000520.93049813
56Amoebiasis_Homo sapiens_hsa051460.92940310
57Graft-versus-host disease_Homo sapiens_hsa053320.92821471
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90289600
59Endocytosis_Homo sapiens_hsa041440.85452749
60Endometrial cancer_Homo sapiens_hsa052130.84445928
61Viral myocarditis_Homo sapiens_hsa054160.83123014
62T cell receptor signaling pathway_Homo sapiens_hsa046600.82780035
63Viral carcinogenesis_Homo sapiens_hsa052030.80605574
64Herpes simplex infection_Homo sapiens_hsa051680.78361558
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.76197291
66Hepatitis C_Homo sapiens_hsa051600.74636039
67Small cell lung cancer_Homo sapiens_hsa052220.74014279
68Focal adhesion_Homo sapiens_hsa045100.72657365
69Glioma_Homo sapiens_hsa052140.70183153
70Fructose and mannose metabolism_Homo sapiens_hsa000510.69072339
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68485087
72Insulin signaling pathway_Homo sapiens_hsa049100.67299592
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65670892
74Prostate cancer_Homo sapiens_hsa052150.65578953
75Thyroid cancer_Homo sapiens_hsa052160.65344136
76Allograft rejection_Homo sapiens_hsa053300.65126846
77Sphingolipid metabolism_Homo sapiens_hsa006000.63642662
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.61416841
79Type II diabetes mellitus_Homo sapiens_hsa049300.60772740
80ECM-receptor interaction_Homo sapiens_hsa045120.60490343
81Sulfur metabolism_Homo sapiens_hsa009200.59592258
82Epstein-Barr virus infection_Homo sapiens_hsa051690.58093843
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57618037
84ErbB signaling pathway_Homo sapiens_hsa040120.57050000
85Insulin resistance_Homo sapiens_hsa049310.56914476
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56677158
87Proteoglycans in cancer_Homo sapiens_hsa052050.56140430
88Prolactin signaling pathway_Homo sapiens_hsa049170.55482665
89Antigen processing and presentation_Homo sapiens_hsa046120.55049300
90mTOR signaling pathway_Homo sapiens_hsa041500.54270772
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52716146
92Prion diseases_Homo sapiens_hsa050200.51078214
93African trypanosomiasis_Homo sapiens_hsa051430.51003441
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.50022078
95Inositol phosphate metabolism_Homo sapiens_hsa005620.48043120
96Collecting duct acid secretion_Homo sapiens_hsa049660.47801070
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47712290
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.47086337
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44814634
100Fatty acid biosynthesis_Homo sapiens_hsa000610.43418454

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