HTN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tryptophan catabolic process (GO:0006569)4.85597605
2indole-containing compound catabolic process (GO:0042436)4.85597605
3indolalkylamine catabolic process (GO:0046218)4.85597605
4indolalkylamine metabolic process (GO:0006586)4.70237681
5kynurenine metabolic process (GO:0070189)4.62334275
6detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.42697496
7tryptophan metabolic process (GO:0006568)4.16620588
8signal peptide processing (GO:0006465)4.13154488
9behavioral response to nicotine (GO:0035095)4.07661528
10detection of light stimulus involved in visual perception (GO:0050908)4.06678541
11detection of light stimulus involved in sensory perception (GO:0050962)4.06678541
12neural tube formation (GO:0001841)3.95526438
13fucose catabolic process (GO:0019317)3.91109820
14L-fucose metabolic process (GO:0042354)3.91109820
15L-fucose catabolic process (GO:0042355)3.91109820
16cilium or flagellum-dependent cell motility (GO:0001539)3.86374725
17protein K11-linked deubiquitination (GO:0035871)3.79945639
18photoreceptor cell maintenance (GO:0045494)3.72275382
19establishment of protein localization to Golgi (GO:0072600)3.52498677
20cellular ketone body metabolic process (GO:0046950)3.51702333
21indole-containing compound metabolic process (GO:0042430)3.49836132
22regulation of hippo signaling (GO:0035330)3.49318694
23reflex (GO:0060004)3.47201816
24positive regulation of developmental pigmentation (GO:0048087)3.39917406
25negative regulation of mast cell activation (GO:0033004)3.26391294
26tachykinin receptor signaling pathway (GO:0007217)3.24247386
27ketone body metabolic process (GO:1902224)3.23875592
28response to pheromone (GO:0019236)3.23090263
29cellular biogenic amine catabolic process (GO:0042402)3.14065655
30amine catabolic process (GO:0009310)3.14065655
31sulfation (GO:0051923)3.12996949
32regulation of pigment cell differentiation (GO:0050932)3.11811006
33negative regulation of cytosolic calcium ion concentration (GO:0051481)3.10728702
34gamma-aminobutyric acid transport (GO:0015812)3.08086986
35monoubiquitinated protein deubiquitination (GO:0035520)3.06971509
36serotonin metabolic process (GO:0042428)3.06163076
37auditory receptor cell stereocilium organization (GO:0060088)3.05267106
38behavioral response to ethanol (GO:0048149)3.04963217
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.03341884
40regulation of sarcomere organization (GO:0060297)3.02478611
41benzene-containing compound metabolic process (GO:0042537)3.02451533
42regulation of establishment of cell polarity (GO:2000114)3.02079460
43protein K48-linked deubiquitination (GO:0071108)2.99909612
44regulation of gene silencing by RNA (GO:0060966)2.98599965
45regulation of posttranscriptional gene silencing (GO:0060147)2.98599965
46regulation of gene silencing by miRNA (GO:0060964)2.98599965
47oxidative demethylation (GO:0070989)2.96374402
48piRNA metabolic process (GO:0034587)2.95158939
49detection of mechanical stimulus involved in sensory perception (GO:0050974)2.94616473
50neuronal action potential (GO:0019228)2.92672018
51axoneme assembly (GO:0035082)2.92321464
52thyroid hormone metabolic process (GO:0042403)2.89890375
53primary amino compound metabolic process (GO:1901160)2.88892838
54cilium morphogenesis (GO:0060271)2.85316788
55retinal cone cell development (GO:0046549)2.84081108
56NAD biosynthetic process (GO:0009435)2.83553102
57cellular response to sterol (GO:0036315)2.83406056
58negative regulation of translation, ncRNA-mediated (GO:0040033)2.83143412
59regulation of translation, ncRNA-mediated (GO:0045974)2.83143412
60negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.83143412
61protein K63-linked deubiquitination (GO:0070536)2.81904362
62inner ear receptor stereocilium organization (GO:0060122)2.80497514
63G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79174646
64aromatic amino acid family catabolic process (GO:0009074)2.73987008
65protein localization to cilium (GO:0061512)2.73396816
66L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70842152
67phospholipid translocation (GO:0045332)2.70120660
68lipid translocation (GO:0034204)2.70120660
69negative regulation of systemic arterial blood pressure (GO:0003085)2.69886121
70cilium organization (GO:0044782)2.69811324
71cilium assembly (GO:0042384)2.65996557
72regulation of action potential (GO:0098900)2.65947677
73flavonoid metabolic process (GO:0009812)2.64969583
74DNA methylation involved in gamete generation (GO:0043046)2.64888283
75regulation of establishment or maintenance of cell polarity (GO:0032878)2.64749734
76membrane depolarization during action potential (GO:0086010)2.64504789
77snRNA transcription (GO:0009301)2.64417958
78adaptation of signaling pathway (GO:0023058)2.63498565
79proline transport (GO:0015824)2.62577780
80cAMP catabolic process (GO:0006198)2.60623944
81epithelial cilium movement (GO:0003351)2.58130011
82recombinational repair (GO:0000725)2.56536857
83double-strand break repair via homologous recombination (GO:0000724)2.55589636
84aromatic amino acid family metabolic process (GO:0009072)2.55355282
85cilium movement (GO:0003341)2.53482456
86prenylation (GO:0097354)2.52507146
87protein prenylation (GO:0018342)2.52507146
88reciprocal DNA recombination (GO:0035825)2.50664629
89reciprocal meiotic recombination (GO:0007131)2.50664629
90nonmotile primary cilium assembly (GO:0035058)2.50461205
91interkinetic nuclear migration (GO:0022027)2.50045127
92dopamine transport (GO:0015872)2.49863840
93transmission of nerve impulse (GO:0019226)2.49754225
94neuronal action potential propagation (GO:0019227)2.49746437
95photoreceptor cell development (GO:0042461)2.47736789
96negative regulation of calcium ion transport into cytosol (GO:0010523)2.46492659
97positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.46219185
98negative regulation of sodium ion transport (GO:0010766)2.45106605
99positive regulation of oligodendrocyte differentiation (GO:0048714)2.44518581
100rhodopsin mediated signaling pathway (GO:0016056)2.44485265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.62378450
2VDR_22108803_ChIP-Seq_LS180_Human3.15232278
3ZNF274_21170338_ChIP-Seq_K562_Hela2.98856318
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.87277825
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78926185
6IGF1R_20145208_ChIP-Seq_DFB_Human2.78816867
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65840523
8* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.59722763
9EZH2_22144423_ChIP-Seq_EOC_Human2.48978603
10TAF15_26573619_Chip-Seq_HEK293_Human2.43799023
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.42405877
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40717325
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.36872825
14P300_19829295_ChIP-Seq_ESCs_Human2.17479349
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.07154314
16FUS_26573619_Chip-Seq_HEK293_Human2.03467175
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00288666
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.99962698
19EWS_26573619_Chip-Seq_HEK293_Human1.99329618
20ER_23166858_ChIP-Seq_MCF-7_Human1.98656727
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.91299526
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91272477
23STAT3_23295773_ChIP-Seq_U87_Human1.85804272
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.85145799
25SMAD4_21799915_ChIP-Seq_A2780_Human1.82152887
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80497358
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.75023486
28BCAT_22108803_ChIP-Seq_LS180_Human1.69690951
29TCF4_23295773_ChIP-Seq_U87_Human1.65500087
30CBP_20019798_ChIP-Seq_JUKART_Human1.62092232
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62092232
32NR3C1_21868756_ChIP-Seq_MCF10A_Human1.60811349
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57775087
34AR_25329375_ChIP-Seq_VCAP_Human1.56546356
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.51219038
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51140237
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51009902
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47326163
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47326163
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46676837
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.46266151
42AR_21572438_ChIP-Seq_LNCaP_Human1.45321473
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43123236
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42795326
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41299016
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.39962267
47TCF4_22108803_ChIP-Seq_LS180_Human1.39873274
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39388442
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38635824
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37038129
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36754935
52PRDM14_20953172_ChIP-Seq_ESCs_Human1.34611225
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33596600
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.33010788
55RUNX2_22187159_ChIP-Seq_PCA_Human1.32806031
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31030538
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29974202
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29696224
59NANOG_19829295_ChIP-Seq_ESCs_Human1.28708758
60SOX2_19829295_ChIP-Seq_ESCs_Human1.28708758
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28650253
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28592228
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28517572
64TP53_22573176_ChIP-Seq_HFKS_Human1.27281577
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27023480
66SMAD4_21741376_ChIP-Seq_EPCs_Human1.26934052
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.26864014
68TP53_16413492_ChIP-PET_HCT116_Human1.25818351
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.23691155
70P53_22387025_ChIP-Seq_ESCs_Mouse1.21122040
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18979479
72REST_21632747_ChIP-Seq_MESCs_Mouse1.18561068
73CDX2_22108803_ChIP-Seq_LS180_Human1.17021268
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16495403
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14975715
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.14731437
77DROSHA_22980978_ChIP-Seq_HELA_Human1.13798347
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12393440
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11085100
80OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10453955
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.10447239
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.10048587
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.09747948
84IRF1_19129219_ChIP-ChIP_H3396_Human1.09401529
85KDM2B_26808549_Chip-Seq_REH_Human1.08514295
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.06365840
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06365840
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06161546
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.05787869
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.05787164
91TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05221408
92SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05193097
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04505676
94P300_18555785_Chip-Seq_ESCs_Mouse1.04431090
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.04160452
96RNF2_27304074_Chip-Seq_NSC_Mouse1.03944665
97AHR_22903824_ChIP-Seq_MCF-7_Human1.01596381
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01404752
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00135656
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99960147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.25211071
2MP0003195_calcinosis3.35744001
3MP0005551_abnormal_eye_electrophysiolog2.74283086
4MP0001501_abnormal_sleep_pattern2.57539860
5MP0002102_abnormal_ear_morphology2.56630932
6MP0001968_abnormal_touch/_nociception2.53317781
7MP0003646_muscle_fatigue2.47291088
8MP0009046_muscle_twitch2.42225797
9MP0008877_abnormal_DNA_methylation2.37843996
10MP0002736_abnormal_nociception_after2.28592098
11MP0002837_dystrophic_cardiac_calcinosis2.22935774
12MP0004043_abnormal_pH_regulation2.14703129
13MP0008057_abnormal_DNA_replication2.04410007
14MP0000427_abnormal_hair_cycle2.02882888
15MP0009745_abnormal_behavioral_response2.00649463
16MP0005253_abnormal_eye_physiology1.91965980
17MP0000372_irregular_coat_pigmentation1.90440613
18MP0008872_abnormal_physiological_respon1.84822054
19MP0003787_abnormal_imprinting1.80795231
20MP0005646_abnormal_pituitary_gland1.79147640
21MP0005174_abnormal_tail_pigmentation1.79094931
22MP0001986_abnormal_taste_sensitivity1.71887453
23MP0003136_yellow_coat_color1.69388835
24MP0006072_abnormal_retinal_apoptosis1.68325648
25MP0006276_abnormal_autonomic_nervous1.66972994
26MP0002735_abnormal_chemical_nociception1.65867837
27MP0001486_abnormal_startle_reflex1.65230690
28MP0002272_abnormal_nervous_system1.62221115
29MP0002876_abnormal_thyroid_physiology1.61647314
30MP0004142_abnormal_muscle_tone1.58838312
31MP0001485_abnormal_pinna_reflex1.57238796
32MP0010386_abnormal_urinary_bladder1.45331627
33MP0003880_abnormal_central_pattern1.45022012
34MP0005645_abnormal_hypothalamus_physiol1.44382903
35MP0001984_abnormal_olfaction1.43333332
36MP0005075_abnormal_melanosome_morpholog1.42390192
37MP0004147_increased_porphyrin_level1.41960004
38MP0002064_seizures1.38575251
39MP0002138_abnormal_hepatobiliary_system1.37908369
40MP0002572_abnormal_emotion/affect_behav1.37226665
41MP0000383_abnormal_hair_follicle1.35829969
42MP0002938_white_spotting1.34432022
43MP0002733_abnormal_thermal_nociception1.34418167
44MP0001970_abnormal_pain_threshold1.34332274
45MP0004145_abnormal_muscle_electrophysio1.34167975
46MP0003252_abnormal_bile_duct1.30453290
47MP0002928_abnormal_bile_duct1.28844792
48MP0005171_absent_coat_pigmentation1.28418299
49MP0005386_behavior/neurological_phenoty1.26411880
50MP0004924_abnormal_behavior1.26411880
51MP0000631_abnormal_neuroendocrine_gland1.26185247
52MP0003950_abnormal_plasma_membrane1.23996495
53MP0005085_abnormal_gallbladder_physiolo1.20782282
54MP0002095_abnormal_skin_pigmentation1.20728733
55MP0003635_abnormal_synaptic_transmissio1.15632120
56MP0002557_abnormal_social/conspecific_i1.14283967
57MP0002067_abnormal_sensory_capabilities1.14121125
58MP0003045_fibrosis1.10885130
59MP0002638_abnormal_pupillary_reflex1.10429547
60MP0000230_abnormal_systemic_arterial1.09811751
61MP0004215_abnormal_myocardial_fiber1.09751908
62MP0005167_abnormal_blood-brain_barrier1.09740499
63MP0005377_hearing/vestibular/ear_phenot1.08432342
64MP0003878_abnormal_ear_physiology1.08432342
65MP0002234_abnormal_pharynx_morphology1.07504839
66MP0004885_abnormal_endolymph1.06573115
67MP0000371_diluted_coat_color1.04746551
68MP0005410_abnormal_fertilization1.00915179
69MP0006054_spinal_hemorrhage0.99980344
70MP0002063_abnormal_learning/memory/cond0.99853252
71MP0008875_abnormal_xenobiotic_pharmacok0.98907085
72MP0000015_abnormal_ear_pigmentation0.98048650
73MP0003011_delayed_dark_adaptation0.97992290
74MP0004742_abnormal_vestibular_system0.97917194
75MP0002653_abnormal_ependyma_morphology0.96849980
76MP0003137_abnormal_impulse_conducting0.96522095
77MP0001324_abnormal_eye_pigmentation0.94000119
78MP0003890_abnormal_embryonic-extraembry0.93881788
79MP0003718_maternal_effect0.93824159
80MP0005195_abnormal_posterior_eye0.93545737
81MP0002229_neurodegeneration0.92700302
82MP0004133_heterotaxia0.92160625
83MP0005389_reproductive_system_phenotype0.91947848
84MP0006292_abnormal_olfactory_placode0.89502002
85MP0005310_abnormal_salivary_gland0.86515638
86MP0003698_abnormal_male_reproductive0.85887876
87MP0000538_abnormal_urinary_bladder0.83156740
88MP0004085_abnormal_heartbeat0.82212182
89MP0005266_abnormal_metabolism0.82047060
90MP0002752_abnormal_somatic_nervous0.80898784
91MP0002734_abnormal_mechanical_nocicepti0.80605849
92MP0005670_abnormal_white_adipose0.80098108
93MP0001963_abnormal_hearing_physiology0.79911518
94MP0003633_abnormal_nervous_system0.79822754
95MP0002693_abnormal_pancreas_physiology0.79551849
96MP0004130_abnormal_muscle_cell0.78786223
97MP0002168_other_aberrant_phenotype0.78383660
98MP0005084_abnormal_gallbladder_morpholo0.78157679
99MP0002160_abnormal_reproductive_system0.73656989
100MP0008961_abnormal_basal_metabolism0.72867632

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.93724412
2Pancreatic fibrosis (HP:0100732)4.35322671
3True hermaphroditism (HP:0010459)4.26335021
4Hyperventilation (HP:0002883)4.14680888
5Genetic anticipation (HP:0003743)4.02632603
6Congenital stationary night blindness (HP:0007642)3.77933410
7Gaze-evoked nystagmus (HP:0000640)3.77846181
8Abnormality of midbrain morphology (HP:0002418)3.64202174
9Molar tooth sign on MRI (HP:0002419)3.64202174
10Attenuation of retinal blood vessels (HP:0007843)3.56692060
11Abnormality of the renal cortex (HP:0011035)3.53200889
12Progressive cerebellar ataxia (HP:0002073)3.50534487
13Nephronophthisis (HP:0000090)3.42013885
14Cystic liver disease (HP:0006706)3.22676692
15Chronic hepatic failure (HP:0100626)3.21172225
16Abnormality of the renal medulla (HP:0100957)3.20182220
17Abolished electroretinogram (ERG) (HP:0000550)3.12426197
18Medial flaring of the eyebrow (HP:0010747)3.09952655
19Protruding tongue (HP:0010808)2.91944569
20Aplasia/Hypoplasia of the tibia (HP:0005772)2.81987371
21Febrile seizures (HP:0002373)2.76192201
22Congenital sensorineural hearing impairment (HP:0008527)2.72757278
23Inability to walk (HP:0002540)2.72155279
24Clumsiness (HP:0002312)2.71928117
25Absent speech (HP:0001344)2.69067256
26Bony spicule pigmentary retinopathy (HP:0007737)2.64531447
27Fair hair (HP:0002286)2.62644064
28Progressive inability to walk (HP:0002505)2.62275561
29Increased corneal curvature (HP:0100692)2.60340376
30Keratoconus (HP:0000563)2.60340376
31Type II lissencephaly (HP:0007260)2.54622719
32Tubular atrophy (HP:0000092)2.52519524
33Gait imbalance (HP:0002141)2.52428581
34Broad-based gait (HP:0002136)2.52211597
35Aplasia/Hypoplasia of the tongue (HP:0010295)2.52120515
36Renal cortical cysts (HP:0000803)2.50915949
37Focal seizures (HP:0007359)2.47976003
38Congenital primary aphakia (HP:0007707)2.46963532
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45911544
40Abnormality of alanine metabolism (HP:0010916)2.45911544
41Hyperalaninemia (HP:0003348)2.45911544
42Congenital hepatic fibrosis (HP:0002612)2.39513779
43Furrowed tongue (HP:0000221)2.38248325
44Abnormal drinking behavior (HP:0030082)2.37519029
45Polydipsia (HP:0001959)2.37519029
46Sclerocornea (HP:0000647)2.36173744
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.34151380
48Dialeptic seizures (HP:0011146)2.31476285
49Focal motor seizures (HP:0011153)2.30712778
50Decreased central vision (HP:0007663)2.30470855
51Abnormal rod and cone electroretinograms (HP:0008323)2.29971413
52Pendular nystagmus (HP:0012043)2.29431323
53Large for gestational age (HP:0001520)2.28237552
54Central scotoma (HP:0000603)2.27743371
55Nephrogenic diabetes insipidus (HP:0009806)2.26276750
56Genital tract atresia (HP:0001827)2.25160578
57Decreased circulating renin level (HP:0003351)2.22331893
58Abnormality of macular pigmentation (HP:0008002)2.20336875
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.18184812
60Widely spaced teeth (HP:0000687)2.17870235
61Decreased electroretinogram (ERG) amplitude (HP:0000654)2.15941003
62Stomach cancer (HP:0012126)2.14752362
63Postaxial foot polydactyly (HP:0001830)2.14549172
64Anencephaly (HP:0002323)2.14380036
65Vaginal atresia (HP:0000148)2.13113207
66Generalized hypopigmentation of hair (HP:0011358)2.10191454
67Constricted visual fields (HP:0001133)2.08211912
68Lissencephaly (HP:0001339)2.06948856
69Absent/shortened dynein arms (HP:0200106)2.05485276
70Dynein arm defect of respiratory motile cilia (HP:0012255)2.05485276
71Intestinal atresia (HP:0011100)2.03998562
72Cerebellar dysplasia (HP:0007033)2.03925065
73Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03554268
74Hypothermia (HP:0002045)1.97617808
75Male pseudohermaphroditism (HP:0000037)1.97378314
76Small hand (HP:0200055)1.91000639
77Bile duct proliferation (HP:0001408)1.90999263
78Abnormal biliary tract physiology (HP:0012439)1.90999263
79Retinitis pigmentosa (HP:0000510)1.88487576
80Hemiparesis (HP:0001269)1.86464727
81Chorioretinal atrophy (HP:0000533)1.85838176
82Abnormal ciliary motility (HP:0012262)1.84822753
83Severe visual impairment (HP:0001141)1.84545396
84Aplasia/Hypoplasia of the fovea (HP:0008060)1.84333222
85Hypoplasia of the fovea (HP:0007750)1.84333222
86Congenital, generalized hypertrichosis (HP:0004540)1.84287571
87Drooling (HP:0002307)1.84118093
88Polyuria (HP:0000103)1.83946370
89Absence seizures (HP:0002121)1.83219644
90Short foot (HP:0001773)1.81708556
91Poor coordination (HP:0002370)1.79732866
92Hypoplastic ischia (HP:0003175)1.76813992
93Astigmatism (HP:0000483)1.74877238
94Preaxial hand polydactyly (HP:0001177)1.73987430
95Scotoma (HP:0000575)1.73755122
96Patellar aplasia (HP:0006443)1.73366735
97Abnormality of the pons (HP:0007361)1.70125949
98Hypoplasia of the pons (HP:0012110)1.70121563
99Aplasia/Hypoplasia of the uvula (HP:0010293)1.69526325
100Postaxial hand polydactyly (HP:0001162)1.67131044

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.24572768
2ACVR1B2.91201529
3ADRBK22.79703141
4BMPR1B2.78760405
5MAP4K22.48041468
6WNK32.29111565
7GRK12.10300713
8NUAK12.09733415
9TAOK32.05915496
10CASK1.92709999
11ZAK1.87615648
12INSRR1.87528402
13MAPK131.84844387
14OXSR11.74967545
15TNIK1.55195355
16STK38L1.54583200
17PINK11.53064257
18MAP3K41.49578904
19MKNK21.37730770
20TXK1.36726363
21STK391.35368835
22WNK41.30616574
23ADRBK11.28070884
24NTRK31.24849919
25NLK1.14416579
26TRIM281.14339672
27MARK11.12017147
28PIK3CG1.11164285
29DAPK21.02056187
30PAK31.01596587
31PRKCE0.96685229
32LATS10.93161082
33PTK2B0.92032486
34TEC0.91558180
35CAMKK20.91312742
36STK30.89411910
37TGFBR10.87617517
38FER0.85517703
39PLK20.78332670
40PRKCG0.77827562
41ERBB30.77037054
42BRSK20.76887368
43AKT30.75746416
44TNK20.70365238
45CDK190.68851449
46CSNK1G10.68126218
47MUSK0.65056522
48MKNK10.63991389
49BCR0.62682207
50SGK20.62497145
51MAP2K70.62477136
52CSNK1G20.61123868
53PRKAA20.60656166
54PIK3CA0.60586987
55CSNK1A1L0.59102619
56GRK70.58000203
57CAMK2A0.57606845
58EPHA40.57021338
59TIE10.56729217
60FGFR20.55954634
61KIT0.54654068
62OBSCN0.52352142
63PKN10.52204752
64EIF2AK30.50687480
65TLK10.49855088
66IKBKB0.48325519
67STK380.47519291
68GRK50.47170305
69CSNK1G30.46475282
70IRAK10.46201515
71PLK40.45724673
72STK110.43862770
73FLT30.43722377
74ITK0.43277418
75MAPKAPK30.43230448
76TRPM70.42416264
77MAP3K70.42213117
78CSNK1D0.42033808
79PRKACA0.41046032
80MAP2K60.40256266
81MAPKAPK50.39801992
82EPHA30.39090137
83CHUK0.37017737
84PRKCQ0.35751422
85PRKG10.35679080
86NTRK20.34748902
87CAMK10.34259396
88PHKG10.33689645
89PHKG20.33689645
90ERBB20.33177836
91DYRK20.32341011
92PRKAA10.31796499
93VRK10.31761295
94CSNK1A10.31756065
95MST40.31475638
96DYRK1A0.30382907
97MELK0.30298579
98PRKACB0.29251268
99CDK30.28144533
100CAMK40.27985744

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.84374881
2Butanoate metabolism_Homo sapiens_hsa006502.74465822
3Nicotine addiction_Homo sapiens_hsa050332.53162815
4Linoleic acid metabolism_Homo sapiens_hsa005912.42185730
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.36090529
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.31185663
7Nitrogen metabolism_Homo sapiens_hsa009102.24932852
8Tryptophan metabolism_Homo sapiens_hsa003802.17884352
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.17123571
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12386900
11ABC transporters_Homo sapiens_hsa020102.11973187
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.07985821
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99219413
14Homologous recombination_Homo sapiens_hsa034401.93544048
15Taste transduction_Homo sapiens_hsa047421.91461809
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.89577038
17Ether lipid metabolism_Homo sapiens_hsa005651.82333339
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80879584
19Morphine addiction_Homo sapiens_hsa050321.71568808
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.67029272
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.65887117
22Olfactory transduction_Homo sapiens_hsa047401.65183519
23Selenocompound metabolism_Homo sapiens_hsa004501.55501573
24Propanoate metabolism_Homo sapiens_hsa006401.50308431
25Fanconi anemia pathway_Homo sapiens_hsa034601.47721640
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46155017
27Circadian entrainment_Homo sapiens_hsa047131.42481541
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40476088
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38770192
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36597900
31GABAergic synapse_Homo sapiens_hsa047271.34784259
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33639597
33Glutamatergic synapse_Homo sapiens_hsa047241.33357836
34Serotonergic synapse_Homo sapiens_hsa047261.32523519
35Caffeine metabolism_Homo sapiens_hsa002321.29071542
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28138827
37Retinol metabolism_Homo sapiens_hsa008301.25860723
38Chemical carcinogenesis_Homo sapiens_hsa052041.25741615
39Basal transcription factors_Homo sapiens_hsa030221.19747126
40Histidine metabolism_Homo sapiens_hsa003401.18164131
41Glycerolipid metabolism_Homo sapiens_hsa005611.17934917
42Insulin secretion_Homo sapiens_hsa049111.14842785
43Calcium signaling pathway_Homo sapiens_hsa040201.14691726
44beta-Alanine metabolism_Homo sapiens_hsa004101.10542786
45* Salivary secretion_Homo sapiens_hsa049701.08789968
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.06743865
47Ovarian steroidogenesis_Homo sapiens_hsa049131.05430783
48Arachidonic acid metabolism_Homo sapiens_hsa005900.99750146
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97678108
50Dorso-ventral axis formation_Homo sapiens_hsa043200.96631594
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91930003
52Peroxisome_Homo sapiens_hsa041460.91861161
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.89212361
54Regulation of autophagy_Homo sapiens_hsa041400.88250057
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82409733
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77623591
57Renin secretion_Homo sapiens_hsa049240.76805174
58Long-term depression_Homo sapiens_hsa047300.76288626
59Non-homologous end-joining_Homo sapiens_hsa034500.73871613
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73707997
61Sphingolipid metabolism_Homo sapiens_hsa006000.73366955
62Fatty acid biosynthesis_Homo sapiens_hsa000610.72668273
63Asthma_Homo sapiens_hsa053100.71183024
64RNA polymerase_Homo sapiens_hsa030200.71167922
65Circadian rhythm_Homo sapiens_hsa047100.66976629
66Fatty acid degradation_Homo sapiens_hsa000710.66834387
67Gastric acid secretion_Homo sapiens_hsa049710.66569331
68Cholinergic synapse_Homo sapiens_hsa047250.64671546
69Dopaminergic synapse_Homo sapiens_hsa047280.64203561
70Oxytocin signaling pathway_Homo sapiens_hsa049210.62236608
71cAMP signaling pathway_Homo sapiens_hsa040240.61447443
72One carbon pool by folate_Homo sapiens_hsa006700.61314470
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.60827911
74Primary immunodeficiency_Homo sapiens_hsa053400.56090408
75Lysine degradation_Homo sapiens_hsa003100.55120102
76RNA degradation_Homo sapiens_hsa030180.51704370
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51200833
78Protein export_Homo sapiens_hsa030600.50654792
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49900268
80Fat digestion and absorption_Homo sapiens_hsa049750.48361382
81Graft-versus-host disease_Homo sapiens_hsa053320.47026522
82Pancreatic secretion_Homo sapiens_hsa049720.46222091
83Purine metabolism_Homo sapiens_hsa002300.45919211
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45344255
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42046851
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41458494
87Fatty acid metabolism_Homo sapiens_hsa012120.40453855
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40027377
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38788583
90Amphetamine addiction_Homo sapiens_hsa050310.37805786
91Metabolic pathways_Homo sapiens_hsa011000.35201479
92Type I diabetes mellitus_Homo sapiens_hsa049400.35166336
93Type II diabetes mellitus_Homo sapiens_hsa049300.33770592
94Collecting duct acid secretion_Homo sapiens_hsa049660.29469468
95Mineral absorption_Homo sapiens_hsa049780.29445763
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.29077527
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26495303
98Platelet activation_Homo sapiens_hsa046110.25886952
99Cocaine addiction_Homo sapiens_hsa050300.24245196
100Bile secretion_Homo sapiens_hsa049760.22622497

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