HTR1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1blood vessel maturation (GO:0001955)8.92432781
2endothelium development (GO:0003158)8.50066959
3lymphangiogenesis (GO:0001946)8.41069189
4wound healing, spreading of epidermal cells (GO:0035313)7.30255914
5positive regulation of endothelial cell differentiation (GO:0045603)5.99123812
6retina vasculature morphogenesis in camera-type eye (GO:0061299)5.73284401
7regulation of glomerular filtration (GO:0003093)4.99812606
8negative regulation of focal adhesion assembly (GO:0051895)4.87931535
9negative regulation of cell junction assembly (GO:1901889)4.87931535
10negative regulation of adherens junction organization (GO:1903392)4.87931535
11wound healing, spreading of cells (GO:0044319)4.87724390
12negative regulation of blood vessel endothelial cell migration (GO:0043537)4.85028799
13sprouting angiogenesis (GO:0002040)4.74893894
14artery development (GO:0060840)4.72156536
15regulation of endothelial cell differentiation (GO:0045601)4.66421499
16morphogenesis of an endothelium (GO:0003159)4.59748927
17endothelial tube morphogenesis (GO:0061154)4.59748927
18positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)4.59312938
19substrate-dependent cell migration (GO:0006929)4.59089368
20response to pheromone (GO:0019236)4.47201632
21vocalization behavior (GO:0071625)4.32453388
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.29713463
23positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-4.27786375
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.26362201
25ionotropic glutamate receptor signaling pathway (GO:0035235)4.23850409
26positive regulation of blood vessel endothelial cell migration (GO:0043536)4.10232165
27cell adhesion mediated by integrin (GO:0033627)4.02122825
28locomotory exploration behavior (GO:0035641)4.00879709
29regulation of synapse structural plasticity (GO:0051823)3.97437016
30regulation of short-term neuronal synaptic plasticity (GO:0048172)3.92225987
31lymph vessel development (GO:0001945)3.90879181
32glutamate receptor signaling pathway (GO:0007215)3.89556799
33regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.86963247
34synaptic vesicle maturation (GO:0016188)3.86309202
35positive regulation of endothelial cell migration (GO:0010595)3.85929030
36regulation of chemokine-mediated signaling pathway (GO:0070099)3.85759152
37regulation of glutamate receptor signaling pathway (GO:1900449)3.83413063
38vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.82818520
39endodermal cell differentiation (GO:0035987)3.82571460
40protein localization to synapse (GO:0035418)3.82171448
41embryonic heart tube development (GO:0035050)3.78318963
42response to magnesium ion (GO:0032026)3.77561642
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.74060209
44regulation of blood vessel endothelial cell migration (GO:0043535)3.72779140
45positive regulation of odontogenesis (GO:0042482)3.71565724
46positive regulation of urine volume (GO:0035810)3.70184344
47cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.69422777
48negative regulation of chondrocyte differentiation (GO:0032331)3.68886569
49neuron-neuron synaptic transmission (GO:0007270)3.63868245
50negative regulation of endothelial cell proliferation (GO:0001937)3.63451087
51negative regulation of endothelial cell migration (GO:0010596)3.63027852
52synaptic transmission, glutamatergic (GO:0035249)3.60757189
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.59473793
54positive regulation of chondrocyte differentiation (GO:0032332)3.58098774
55endothelial cell proliferation (GO:0001935)3.57795596
56endothelial cell differentiation (GO:0045446)3.57764600
57patterning of blood vessels (GO:0001569)3.53622968
58negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.53104888
59synaptic vesicle docking involved in exocytosis (GO:0016081)3.52111083
60negative regulation of fatty acid transport (GO:2000192)3.51279783
61positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.51050751
62protein localization to endosome (GO:0036010)3.49135741
63negative regulation of nitric-oxide synthase activity (GO:0051001)3.48631725
64neuron cell-cell adhesion (GO:0007158)3.47255655
65vascular endothelial growth factor signaling pathway (GO:0038084)3.45839352
66neurotransmitter-gated ion channel clustering (GO:0072578)3.44235254
67regulation of chondrocyte differentiation (GO:0032330)3.41959030
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.41237557
69regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)3.39586028
70type B pancreatic cell development (GO:0003323)3.39512871
71regulation of plasminogen activation (GO:0010755)3.39482818
72anatomical structure maturation (GO:0071695)3.38402481
73regulation of synaptic vesicle exocytosis (GO:2000300)3.37886631
74positive regulation of cartilage development (GO:0061036)3.37379039
75regulation of neuronal synaptic plasticity (GO:0048168)3.34330553
76positive regulation of interleukin-8 secretion (GO:2000484)3.33739393
77axonal fasciculation (GO:0007413)3.32418723
78exploration behavior (GO:0035640)3.32099567
79pathway-restricted SMAD protein phosphorylation (GO:0060389)3.29774006
80positive regulation of fibroblast migration (GO:0010763)3.29680892
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.28993015
82negative regulation of cell-substrate adhesion (GO:0010812)3.28496678
83synaptic vesicle exocytosis (GO:0016079)3.27102060
84negative regulation of cell-matrix adhesion (GO:0001953)3.26673652
85regulation of endothelial cell migration (GO:0010594)3.25372730
86transmission of nerve impulse (GO:0019226)3.25066694
87synaptic transmission, dopaminergic (GO:0001963)3.23634932
88neuron recognition (GO:0008038)3.23171459
89adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.21851844
90behavioral response to cocaine (GO:0048148)3.21704885
91regulation of excitatory postsynaptic membrane potential (GO:0060079)3.19860332
92positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.19780632
93positive regulation of epithelial cell migration (GO:0010634)3.19394611
94regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.19307362
95prepulse inhibition (GO:0060134)3.18916107
96apoptotic cell clearance (GO:0043277)3.16901806
97* negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.16588284
98renal system process involved in regulation of blood volume (GO:0001977)3.16077810
99startle response (GO:0001964)3.15099527
100regulation of dendritic spine morphogenesis (GO:0061001)3.15085412
101long-term memory (GO:0007616)3.14218696
102response to auditory stimulus (GO:0010996)3.13379675
103* regulation of synaptic transmission, glutamatergic (GO:0051966)3.13299322
104dendritic spine morphogenesis (GO:0060997)3.13157916
105regulation of transforming growth factor beta1 production (GO:0032908)3.12016095
106response to histamine (GO:0034776)3.10212262
107neuronal action potential propagation (GO:0019227)3.09897744
108plasma membrane repair (GO:0001778)3.09397675
109basement membrane organization (GO:0071711)3.09143739
110striatum development (GO:0021756)3.06759535
111neuron projection extension involved in neuron projection guidance (GO:1902284)3.06751543
112axon extension involved in axon guidance (GO:0048846)3.06751543
113substrate adhesion-dependent cell spreading (GO:0034446)3.05652763
114negative regulation of DNA biosynthetic process (GO:2000279)3.05479497
115negative regulation of fibrinolysis (GO:0051918)3.05263014
116gamma-aminobutyric acid signaling pathway (GO:0007214)3.05250596
117activin receptor signaling pathway (GO:0032924)3.04870663
118regulation of postsynaptic membrane potential (GO:0060078)3.04039613
119long term synaptic depression (GO:0060292)3.03988974
120neural crest cell development (GO:0014032)3.03032967
121response to amphetamine (GO:0001975)3.02629016
122endocardial cushion development (GO:0003197)3.02554746
123positive regulation of neurotransmitter secretion (GO:0001956)3.01932656
124regulation of synaptic vesicle transport (GO:1902803)3.00982060
125venous blood vessel morphogenesis (GO:0048845)2.98746247
126regulation of sarcomere organization (GO:0060297)2.96711725
127cytoskeletal anchoring at plasma membrane (GO:0007016)2.95653950
128renal filtration (GO:0097205)2.93707807
129dopamine receptor signaling pathway (GO:0007212)2.93589251
130angiogenesis (GO:0001525)2.93257905
131positive regulation of cell size (GO:0045793)2.93013873
132positive regulation of neurotransmitter transport (GO:0051590)2.92193936
133regulation of cartilage development (GO:0061035)2.91536524
134behavioral fear response (GO:0001662)2.90269198
135behavioral defense response (GO:0002209)2.90269198
136negative regulation of dendrite development (GO:2000171)2.90047185
137neuromuscular process controlling balance (GO:0050885)2.89761702
138regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89753179
139regulation of synaptic plasticity (GO:0048167)2.89679914
140regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.89489422
141histamine secretion (GO:0001821)2.89028745
142angiogenesis involved in wound healing (GO:0060055)2.88482435
143positive regulation of endothelial cell apoptotic process (GO:2000353)2.87118317
144cell migration involved in sprouting angiogenesis (GO:0002042)2.86832455
145chondrocyte proliferation (GO:0035988)2.86137475
146glutamate secretion (GO:0014047)2.85986206
147glomerular filtration (GO:0003094)2.85631987
148proline transport (GO:0015824)2.84026926
149tonic smooth muscle contraction (GO:0014820)2.83496219
150facial nerve structural organization (GO:0021612)2.82959569
151auditory behavior (GO:0031223)2.82263404
152dendritic spine organization (GO:0097061)2.82171368
153sequestering of extracellular ligand from receptor (GO:0035581)2.81926801
154negative regulation of epithelial cell migration (GO:0010633)2.81855827
155cell migration involved in heart development (GO:0060973)2.81014704
156learning (GO:0007612)2.80810084
157negative chemotaxis (GO:0050919)2.79646750
158positive regulation of smooth muscle contraction (GO:0045987)2.79615557
159positive regulation of macrophage activation (GO:0043032)2.77540976
160regulation of integrin activation (GO:0033623)2.77147970
161nephron epithelium development (GO:0072009)2.76160766
162presynaptic membrane assembly (GO:0097105)2.76012701
163mating behavior (GO:0007617)2.75828073
164G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.75598922
165positive regulation of hormone biosynthetic process (GO:0046886)2.74261997
166artery smooth muscle contraction (GO:0014824)2.74046102
167long-term synaptic potentiation (GO:0060291)2.72947487
168neurotransmitter secretion (GO:0007269)2.71491982
169innervation (GO:0060384)2.71063448
170regulation of female receptivity (GO:0045924)2.69433171
171presynaptic membrane organization (GO:0097090)2.69336452
172positive regulation of membrane potential (GO:0045838)2.68694809
173neuronal ion channel clustering (GO:0045161)2.67856920
174cAMP catabolic process (GO:0006198)2.67598237
175dendrite morphogenesis (GO:0048813)2.67567144
176negative regulation of dendrite morphogenesis (GO:0050774)2.66697521
177regulation of dendritic spine development (GO:0060998)2.63274023
178membrane depolarization (GO:0051899)2.59977259
179regulation of glutamate secretion (GO:0014048)2.59416686
180fear response (GO:0042596)2.58804121
181urinary tract smooth muscle contraction (GO:0014848)2.57191600
182synapse assembly (GO:0007416)2.56945368
183neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.56863156
184postsynaptic membrane organization (GO:0001941)2.56269598
185neuromuscular process (GO:0050905)2.55690832
186positive regulation of synapse maturation (GO:0090129)2.55594375
187* regulation of synaptic transmission, GABAergic (GO:0032228)2.54729812
188neuron remodeling (GO:0016322)2.53756569
189layer formation in cerebral cortex (GO:0021819)2.53747089
190visual learning (GO:0008542)2.52678822
191regulation of neurotransmitter secretion (GO:0046928)2.51823820
192membrane depolarization during action potential (GO:0086010)2.51402505
193cellular potassium ion homeostasis (GO:0030007)2.47264704
194regulation of voltage-gated calcium channel activity (GO:1901385)2.46775623
195cerebellar Purkinje cell differentiation (GO:0021702)2.46274106

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_21666600_ChIP-Seq_HMVEC_Human5.05954181
2EZH2_22144423_ChIP-Seq_EOC_Human4.63772965
3GBX2_23144817_ChIP-Seq_PC3_Human3.85090422
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95581409
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84846735
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.84815104
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60346595
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60346595
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59681840
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41206978
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41172432
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40231075
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.36811807
14* CJUN_26792858_Chip-Seq_BT549_Human2.36097007
15* EZH2_27304074_Chip-Seq_ESCs_Mouse2.31650276
16* EED_16625203_ChIP-ChIP_MESCs_Mouse2.30991353
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22534445
18* BRD4_25478319_ChIP-Seq_HGPS_Human2.17843496
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15054971
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.14007985
21DROSHA_22980978_ChIP-Seq_HELA_Human2.13311633
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.11101548
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.05971025
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05064285
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.90422774
26* RARB_27405468_Chip-Seq_BRAIN_Mouse1.87355568
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86774973
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.85605357
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84728588
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.83621535
31REST_21632747_ChIP-Seq_MESCs_Mouse1.82563566
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.81811929
33SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.81564649
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78509222
35AR_21572438_ChIP-Seq_LNCaP_Human1.77658585
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76733115
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75419023
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.71483307
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71213606
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69986566
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67769517
42RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.67572937
43SMAD4_21799915_ChIP-Seq_A2780_Human1.67567533
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66566395
45TAF15_26573619_Chip-Seq_HEK293_Human1.66107050
46SALL4_18804426_ChIP-ChIP_XEN_Mouse1.65522361
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63344602
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.62858731
49* P300_19829295_ChIP-Seq_ESCs_Human1.62580804
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61532338
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58918692
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.58753206
53* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50658447
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50176280
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48476244
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.47612151
57SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.47612151
58* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46072277
59TP53_18474530_ChIP-ChIP_U2OS_Human1.45940132
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45002343
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.43486746
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42454709
63TRIM28_21343339_ChIP-Seq_HEK293_Human1.41943042
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.41146956
65TP53_16413492_ChIP-PET_HCT116_Human1.39430110
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38999895
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38199568
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37667191
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36588561
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36198637
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35649661
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.35119975
73TBX20_22080862_ChIP-Seq_HEART_Mouse1.33279662
74TBX20_22328084_ChIP-Seq_HEART_Mouse1.33279662
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32119359
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31710662
77ELK4_26923725_Chip-Seq_MESODERM_Mouse1.30036814
78SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28567677
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27561588
80REST_18959480_ChIP-ChIP_MESCs_Mouse1.27311549
81STAT3_23295773_ChIP-Seq_U87_Human1.25842933
82* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25704457
83AR_25329375_ChIP-Seq_VCAP_Human1.25372575
84* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25111963
85RNF2_27304074_Chip-Seq_NSC_Mouse1.25018705
86TP53_23651856_ChIP-Seq_MEFs_Mouse1.24647511
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24322076
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22656891
89PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.22361802
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.21731615
91* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21601358
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21526911
93* ISL1_27105846_Chip-Seq_CPCs_Mouse1.20747640
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20679097
95EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20331511
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20185097
97AR_19668381_ChIP-Seq_PC3_Human1.18934096
98RXR_22108803_ChIP-Seq_LS180_Human1.18641180
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18162107
100* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16604102
101* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16527643
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16302427
103CLOCK_20551151_ChIP-Seq_293T_Human1.16131287
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.16100876
105TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15577364
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14259122
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14228480
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13582016
109AHR_22903824_ChIP-Seq_MCF-7_Human1.13439877
110* JUN_21703547_ChIP-Seq_K562_Human1.13411532
111RUNX2_22187159_ChIP-Seq_PCA_Human1.12453608
112ARNT_22903824_ChIP-Seq_MCF-7_Human1.11888276
113TCF4_23295773_ChIP-Seq_U87_Human1.11672610
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.11112297
115RING1B_27294783_Chip-Seq_ESCs_Mouse1.11005797
116FUS_26573619_Chip-Seq_HEK293_Human1.10124554
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.09959318
118FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09885016
119WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09609304
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.09549512
121IGF1R_20145208_ChIP-Seq_DFB_Human1.09431093
122STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08456868
123P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07361465
124SMAD3_21741376_ChIP-Seq_HESCs_Human1.07353254
125ER_23166858_ChIP-Seq_MCF-7_Human1.07192035
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06808270
127NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06808270
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06686226
129WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05976016
130NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05314662
131WT1_19549856_ChIP-ChIP_CCG9911_Human1.05091507
132KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05003173
133ZNF274_21170338_ChIP-Seq_K562_Hela1.03817887
134E2F1_18555785_Chip-Seq_ESCs_Mouse1.03811951
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01845510
136BCAT_22108803_ChIP-Seq_LS180_Human1.00999567
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99898997
138PRDM14_20953172_ChIP-Seq_ESCs_Human0.99734804
139CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99344161
140SOX9_26525672_Chip-Seq_HEART_Mouse0.98807656
141* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98794558
142YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98664015
143* TET1_21490601_ChIP-Seq_MESCs_Mouse0.98032859
144TP53_22127205_ChIP-Seq_IMR90_Human0.97800465
145PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97402001
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.97117750
147HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96973796
148EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96787867
149TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96461632
150TP53_20018659_ChIP-ChIP_R1E_Mouse0.96264050
151ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95191780
152SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93968543
153ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.92831936
154UBF1/2_26484160_Chip-Seq_HMECs_Human0.92631129
155OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91750601
156NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91070962
157TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90168590

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.59992497
2MP0004859_abnormal_synaptic_plasticity5.35672457
3MP0004272_abnormal_basement_membrane5.00382555
4MP0003880_abnormal_central_pattern4.49609939
5MP0001879_abnormal_lymphatic_vessel4.25950450
6MP0002822_catalepsy3.96647171
7MP0003635_abnormal_synaptic_transmissio3.46344968
8MP0003705_abnormal_hypodermis_morpholog3.27471749
9MP0005167_abnormal_blood-brain_barrier3.23632756
10MP0009745_abnormal_behavioral_response3.17779007
11* MP0002063_abnormal_learning/memory/cond2.96852543
12MP0010030_abnormal_orbit_morphology2.84254892
13MP0004270_analgesia2.81803139
14MP0001968_abnormal_touch/_nociception2.80392521
15MP0000767_abnormal_smooth_muscle2.63813281
16MP0000465_gastrointestinal_hemorrhage2.62018069
17MP0002736_abnormal_nociception_after2.55243011
18* MP0002572_abnormal_emotion/affect_behav2.50716144
19MP0003828_pulmonary_edema2.46410207
20MP0002064_seizures2.45958706
21MP0009046_muscle_twitch2.44382760
22MP0003950_abnormal_plasma_membrane2.35954012
23MP0002735_abnormal_chemical_nociception2.32180225
24* MP0001486_abnormal_startle_reflex2.30589587
25MP0001188_hyperpigmentation2.26532179
26MP0001501_abnormal_sleep_pattern2.25502103
27MP0004233_abnormal_muscle_weight2.16937300
28MP0002272_abnormal_nervous_system2.15371498
29MP0005623_abnormal_meninges_morphology2.12133422
30MP0010352_gastrointestinal_tract_polyps2.07789230
31MP0002734_abnormal_mechanical_nocicepti2.07274991
32MP0006276_abnormal_autonomic_nervous2.01035746
33MP0009697_abnormal_copulation1.92190107
34MP0005646_abnormal_pituitary_gland1.88303551
35MP0001440_abnormal_grooming_behavior1.84767120
36MP0001529_abnormal_vocalization1.82254529
37MP0002138_abnormal_hepatobiliary_system1.79886051
38MP0002877_abnormal_melanocyte_morpholog1.79473948
39MP0005423_abnormal_somatic_nervous1.79112412
40MP0008438_abnormal_cutaneous_collagen1.78169011
41MP0002184_abnormal_innervation1.69888983
42MP0001970_abnormal_pain_threshold1.68000777
43MP0001984_abnormal_olfaction1.66029360
44MP0001915_intracranial_hemorrhage1.63705771
45MP0002067_abnormal_sensory_capabilities1.57588444
46* MP0002557_abnormal_social/conspecific_i1.55825521
47MP0000778_abnormal_nervous_system1.52706289
48MP0003879_abnormal_hair_cell1.51893479
49MP0005409_darkened_coat_color1.51481435
50MP0003787_abnormal_imprinting1.50404358
51MP0002733_abnormal_thermal_nociception1.49400808
52MP0003283_abnormal_digestive_organ1.48691695
53MP0006054_spinal_hemorrhage1.48259233
54MP0005645_abnormal_hypothalamus_physiol1.48187783
55MP0003300_gastrointestinal_ulcer1.43908261
56MP0005386_behavior/neurological_phenoty1.41455838
57MP0004924_abnormal_behavior1.41455838
58MP0002127_abnormal_cardiovascular_syste1.40603105
59MP0001614_abnormal_blood_vessel1.39411665
60MP0004811_abnormal_neuron_physiology1.37921925
61MP0001177_atelectasis1.32618902
62MP0003045_fibrosis1.32426363
63MP0003279_aneurysm1.31970856
64MP0005171_absent_coat_pigmentation1.28331424
65MP0002925_abnormal_cardiovascular_devel1.27881013
66MP0006138_congestive_heart_failure1.27298291
67MP0004742_abnormal_vestibular_system1.26554680
68MP0000537_abnormal_urethra_morphology1.26130756
69MP0001299_abnormal_eye_distance/1.22143020
70MP0000049_abnormal_middle_ear1.21994950
71MP0001502_abnormal_circadian_rhythm1.20584768
72MP0002128_abnormal_blood_circulation1.20075470
73MP0005084_abnormal_gallbladder_morpholo1.19535848
74MP0005503_abnormal_tendon_morphology1.19075363
75MP0008569_lethality_at_weaning1.15230973
76MP0000569_abnormal_digit_pigmentation1.14537791
77MP0001348_abnormal_lacrimal_gland1.13707665
78MP0004858_abnormal_nervous_system1.12573180
79MP0002168_other_aberrant_phenotype1.12318508
80MP0002092_abnormal_eye_morphology1.11367081
81MP0002332_abnormal_exercise_endurance1.09705314
82MP0009780_abnormal_chondrocyte_physiolo1.09529270
83MP0002882_abnormal_neuron_morphology1.08661110
84MP0002909_abnormal_adrenal_gland1.08121002
85MP0005023_abnormal_wound_healing1.07412773
86MP0009250_abnormal_appendicular_skeleto1.06729708
87* MP0002066_abnormal_motor_capabilities/c1.06688294
88MP0010386_abnormal_urinary_bladder1.06179021
89MP0003091_abnormal_cell_migration1.05428187
90MP0002932_abnormal_joint_morphology1.04405611
91MP0000467_abnormal_esophagus_morphology1.04009447
92MP0003935_abnormal_craniofacial_develop1.03687822
93MP0000733_abnormal_muscle_development1.03071129
94MP0002277_abnormal_respiratory_mucosa1.02168800
95MP0000955_abnormal_spinal_cord1.02069713
96MP0005197_abnormal_uvea_morphology1.01672335
97MP0003329_amyloid_beta_deposits1.01488287
98MP0005275_abnormal_skin_tensile1.00724262
99MP0005257_abnormal_intraocular_pressure1.00264241
100MP0001849_ear_inflammation0.98770202
101MP0003385_abnormal_body_wall0.96930133
102MP0004885_abnormal_endolymph0.96248654
103MP0003868_abnormal_feces_composition0.93414971
104MP0002896_abnormal_bone_mineralization0.93052231
105MP0000013_abnormal_adipose_tissue0.87973991
106MP0001243_abnormal_dermal_layer0.86308273
107MP0001293_anophthalmia0.86050680
108MP0003633_abnormal_nervous_system0.86047454
109MP0000631_abnormal_neuroendocrine_gland0.82689023
110MP0001905_abnormal_dopamine_level0.82067291
111MP0002152_abnormal_brain_morphology0.81808984
112MP0000613_abnormal_salivary_gland0.81725749
113MP0005508_abnormal_skeleton_morphology0.81529563
114MP0000249_abnormal_blood_vessel0.80887434
115MP0000751_myopathy0.80820761
116MP0003303_peritoneal_inflammation0.80213717
117MP0008874_decreased_physiological_sensi0.79892489
118MP0002295_abnormal_pulmonary_circulatio0.79194331
119MP0000762_abnormal_tongue_morphology0.77841309
120MP0005394_taste/olfaction_phenotype0.77427643
121MP0005499_abnormal_olfactory_system0.77427643
122MP0004084_abnormal_cardiac_muscle0.77302066
123MP0000534_abnormal_ureter_morphology0.77127512
124MP0002697_abnormal_eye_size0.76612362
125MP0004085_abnormal_heartbeat0.76351710
126MP0001784_abnormal_fluid_regulation0.75779900
127MP0005595_abnormal_vascular_smooth0.74354039
128MP0003984_embryonic_growth_retardation0.72622583
129MP0003631_nervous_system_phenotype0.72349331
130MP0003755_abnormal_palate_morphology0.72056451
131MP0003122_maternal_imprinting0.71723984
132MP0000343_altered_response_to0.71046872
133* MP0000266_abnormal_heart_morphology0.70879478
134MP0004133_heterotaxia0.70769295
135MP0001346_abnormal_lacrimal_gland0.70378448
136MP0005165_increased_susceptibility_to0.68221384
137MP0006292_abnormal_olfactory_placode0.67687587
138MP0003941_abnormal_skin_development0.67091615
139MP0001963_abnormal_hearing_physiology0.66614745
140MP0002933_joint_inflammation0.66583989
141MP0003566_abnormal_cell_adhesion0.65574045
142MP0005193_abnormal_anterior_eye0.64627087
143MP0002088_abnormal_embryonic_growth/wei0.64559677
144MP0003075_altered_response_to0.63766589
145MP0005551_abnormal_eye_electrophysiolog0.63646160
146MP0004510_myositis0.63432551
147MP0002086_abnormal_extraembryonic_tissu0.62392154
148MP0004883_abnormal_blood_vessel0.62048604
149* MP0002069_abnormal_eating/drinking_beha0.61472686
150MP0003191_abnormal_cellular_cholesterol0.61336871
151MP0002177_abnormal_outer_ear0.61190642
152MP0001958_emphysema0.60820825
153MP0010630_abnormal_cardiac_muscle0.60666204
154MP0002752_abnormal_somatic_nervous0.60336205
155MP0001485_abnormal_pinna_reflex0.59615495
156MP0005385_cardiovascular_system_phenoty0.58914114
157MP0001544_abnormal_cardiovascular_syste0.58914114
158MP0005395_other_phenotype0.58849278
159MP0002876_abnormal_thyroid_physiology0.57874248
160MP0004484_altered_response_of0.57287576
161MP0002114_abnormal_axial_skeleton0.57050959
162MP0004145_abnormal_muscle_electrophysio0.56960958
163MP0005380_embryogenesis_phenotype0.55345065
164MP0001672_abnormal_embryogenesis/_devel0.55345065
165MP0002133_abnormal_respiratory_system0.55134298
166MP0005388_respiratory_system_phenotype0.55134298
167MP0000759_abnormal_skeletal_muscle0.54399836
168MP0002085_abnormal_embryonic_tissue0.53907983

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.50744137
2Myokymia (HP:0002411)5.18259444
3Wrist flexion contracture (HP:0001239)4.85983227
4Focal seizures (HP:0007359)4.66490202
5Hematochezia (HP:0002573)4.40274802
6Spontaneous hematomas (HP:0007420)4.39914534
7Febrile seizures (HP:0002373)4.13166835
8Esophageal varix (HP:0002040)3.85125169
9Atonic seizures (HP:0010819)3.71228524
10Skull defect (HP:0001362)3.67899238
11Spinal rigidity (HP:0003306)3.61262809
12Premature rupture of membranes (HP:0001788)3.60417638
13Aortic aneurysm (HP:0004942)3.60004613
14Epileptic encephalopathy (HP:0200134)3.37075531
15Polycythemia (HP:0001901)3.36077681
16Cervical subluxation (HP:0003308)3.32101581
17Adactyly (HP:0009776)3.26685030
18Absence seizures (HP:0002121)3.26504360
19Conjunctival telangiectasia (HP:0000524)3.23509482
20Mitral valve prolapse (HP:0001634)3.21658938
21Stenosis of the external auditory canal (HP:0000402)3.18730385
22Progressive cerebellar ataxia (HP:0002073)3.11054049
23Cerebral hemorrhage (HP:0001342)3.06230846
24Vertebral clefting (HP:0008428)3.05774147
25Visual hallucinations (HP:0002367)3.03850592
26Aortic valve stenosis (HP:0001650)3.00745904
27Action tremor (HP:0002345)2.96303406
28Dialeptic seizures (HP:0011146)2.93862138
29Termporal pattern (HP:0011008)2.90680898
30Insidious onset (HP:0003587)2.90680898
31Aplasia involving bones of the extremities (HP:0009825)2.84887890
32Aplasia involving bones of the upper limbs (HP:0009823)2.84887890
33Aplasia of the phalanges of the hand (HP:0009802)2.84887890
34Nonimmune hydrops fetalis (HP:0001790)2.84801744
35Generalized tonic-clonic seizures (HP:0002069)2.80279911
36Protrusio acetabuli (HP:0003179)2.75199783
37Wormian bones (HP:0002645)2.73501958
38Difficulty climbing stairs (HP:0003551)2.73156861
39Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71568709
40Short 4th metacarpal (HP:0010044)2.71568709
41Portal hypertension (HP:0001409)2.65373503
42Lower limb amyotrophy (HP:0007210)2.65370858
43Broad-based gait (HP:0002136)2.61002940
44Lymphangioma (HP:0100764)2.57165415
45Myotonia (HP:0002486)2.56554183
46Joint contractures involving the joints of the feet (HP:0100492)2.55463933
47Flexion contracture of toe (HP:0005830)2.55463933
48Gaze-evoked nystagmus (HP:0000640)2.53903886
49Abnormality of the vasculature of the conjunctiva (HP:0008054)2.51001147
50Broad face (HP:0000283)2.49540263
51Hemangiomatosis (HP:0007461)2.48171483
52Visceral angiomatosis (HP:0100761)2.40257159
53Distal lower limb amyotrophy (HP:0008944)2.39799585
54Absent speech (HP:0001344)2.39793842
55Abnormality of the hepatic vasculature (HP:0006707)2.38933429
56Short nail (HP:0001799)2.36696241
57Absent frontal sinuses (HP:0002688)2.33596738
58Hyperventilation (HP:0002883)2.32737240
59Ectopia lentis (HP:0001083)2.31826804
60Menorrhagia (HP:0000132)2.31550904
61Hip contracture (HP:0003273)2.27930407
62Glossoptosis (HP:0000162)2.26066410
63Bradycardia (HP:0001662)2.25879282
64Vascular tortuosity (HP:0004948)2.25708556
65Dysdiadochokinesis (HP:0002075)2.25636229
66Neonatal death (HP:0003811)2.22636264
67Excessive salivation (HP:0003781)2.19395081
68Drooling (HP:0002307)2.19395081
69Truncal ataxia (HP:0002078)2.17714361
70Anxiety (HP:0000739)2.16949479
71Blue sclerae (HP:0000592)2.16603853
72Disproportionate tall stature (HP:0001519)2.16528813
73Reduced subcutaneous adipose tissue (HP:0003758)2.15596885
74Abnormality of the corticospinal tract (HP:0002492)2.14801324
75Morphological abnormality of the middle ear (HP:0008609)2.11258792
76Aortic dissection (HP:0002647)2.10273611
77Genu recurvatum (HP:0002816)2.10122416
78Camptodactyly of toe (HP:0001836)2.09990227
79Upper limb amyotrophy (HP:0009129)2.09661266
80Distal upper limb amyotrophy (HP:0007149)2.09661266
81Urinary bladder sphincter dysfunction (HP:0002839)2.09635037
82Abnormal vertebral ossification (HP:0100569)2.09346350
83Hand muscle atrophy (HP:0009130)2.08514602
84Shallow orbits (HP:0000586)2.08371247
85Abnormality of the nasal mucosa (HP:0000433)2.08306043
86Limited hip movement (HP:0008800)2.07880244
87Dilatation of the ascending aorta (HP:0005111)2.07735363
88Cerebral aneurysm (HP:0004944)2.04808066
89Ankle contracture (HP:0006466)2.04505038
90Genetic anticipation (HP:0003743)2.02043742
91Abnormality of the acetabulum (HP:0003170)2.01406626
92Arterial tortuosity (HP:0005116)2.00707440
93Poor eye contact (HP:0000817)2.00259831
94Amblyopia (HP:0000646)1.99905589
95Fragile skin (HP:0001030)1.99578128
96Abnormality of the nasal septum (HP:0000419)1.99366473
97Pulmonary hypertension (HP:0002092)1.98828177
98Tetraparesis (HP:0002273)1.98555216
99Fibular aplasia (HP:0002990)1.98155134
100Ankyloglossia (HP:0010296)1.98149647
101Dysmetria (HP:0001310)1.97896021
102Abnormality of the 4th metacarpal (HP:0010012)1.97860292
103Abnormality of dentin (HP:0010299)1.97397875
104Abnormality of the intrinsic pathway (HP:0010989)1.96255517
105Mucosal telangiectasiae (HP:0100579)1.95694573
106Asymmetry of the thorax (HP:0001555)1.95258879
107Trismus (HP:0000211)1.94716097
108Atrophic scars (HP:0001075)1.93841586
109Joint laxity (HP:0001388)1.92902981
110Scanning speech (HP:0002168)1.92693071
111Abnormality of salivation (HP:0100755)1.91365094
112Spinal canal stenosis (HP:0003416)1.91123050
113Protruding tongue (HP:0010808)1.90430576
114Bifid uvula (HP:0000193)1.90407136
115Soft skin (HP:0000977)1.88978104
116Autoamputation (HP:0001218)1.88733777
117Bicuspid aortic valve (HP:0001647)1.87639964
118Torticollis (HP:0000473)1.85167555
119Primary atrial arrhythmia (HP:0001692)1.85047185
120Palpebral edema (HP:0100540)1.84195378
121Impaired vibration sensation in the lower limbs (HP:0002166)1.84080710
122Venous insufficiency (HP:0005293)1.83995282
123Arachnodactyly (HP:0001166)1.83971294
124Bladder diverticulum (HP:0000015)1.83597173
125Short clavicles (HP:0000894)1.82925876
126Atrial fibrillation (HP:0005110)1.82140397
127Abnormality of the anterior chamber (HP:0000593)1.81679896
128Severe short stature (HP:0003510)1.81365891
129Infantile muscular hypotonia (HP:0008947)1.81192793
130Abnormality of the frontal sinuses (HP:0002687)1.80686487
131Impaired smooth pursuit (HP:0007772)1.79729036
132Depression (HP:0000716)1.79721981
133Bowel diverticulosis (HP:0005222)1.79267747
134Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.78564722
135Stereotypic behavior (HP:0000733)1.78171202
136Increased mean platelet volume (HP:0011877)1.78081877
137Supranuclear gaze palsy (HP:0000605)1.77471339
138Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.77411086
139Abnormal EKG (HP:0003115)1.76861471
140Flat face (HP:0012368)1.76694617
141Prolonged QT interval (HP:0001657)1.75899818
142Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75037879
143Papilledema (HP:0001085)1.74426773
144Protruding ear (HP:0000411)1.74242532
145Aneurysm (HP:0002617)1.73388267
146Fetal akinesia sequence (HP:0001989)1.73328569
147Pointed chin (HP:0000307)1.72978235
148Hypoplasia of the iris (HP:0007676)1.72435672
149Venous abnormality (HP:0002624)1.72389482
150Degeneration of the lateral corticospinal tracts (HP:0002314)1.71586015
151Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71586015
152Microcytic anemia (HP:0001935)1.71580749
153Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.71459387
154Annular pancreas (HP:0001734)1.71255516
155Impaired platelet aggregation (HP:0003540)1.71101411
156Abnormal platelet function (HP:0011869)1.71101411
157Abnormal social behavior (HP:0012433)1.69614068
158Impaired social interactions (HP:0000735)1.69614068
159Deeply set eye (HP:0000490)1.69547924
160Cavernous hemangioma (HP:0001048)1.69298044
161Bilateral sensorineural hearing impairment (HP:0008619)1.69260422
162Overgrowth (HP:0001548)1.68808308
163Peritonitis (HP:0002586)1.67904800
164Supraventricular tachycardia (HP:0004755)1.66954568
165Abnormality of oral frenula (HP:0000190)1.66247604
166Supraventricular arrhythmia (HP:0005115)1.64981000
167Aqueductal stenosis (HP:0002410)1.64477310
168Increased number of teeth (HP:0011069)1.64469666
169Postural instability (HP:0002172)1.64413542
170Ulnar claw (HP:0001178)1.63667264
171Exotropia (HP:0000577)1.62552613
172Tubulointerstitial nephritis (HP:0001970)1.62099975
173Ankle clonus (HP:0011448)1.60720567
174Epileptiform EEG discharges (HP:0011182)1.60184177
175Broad ribs (HP:0000885)1.57929204
176Hydroureter (HP:0000072)1.57900661
177Spinal cord lesions (HP:0100561)1.56895999
178Syringomyelia (HP:0003396)1.56895999
179Nuclear cataract (HP:0100018)1.56601509
180Inappropriate behavior (HP:0000719)1.56342819
181Cutaneous finger syndactyly (HP:0010554)1.54882486
182Abnormal eating behavior (HP:0100738)1.51698397

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.04446230
2NTRK34.84688760
3TGFBR23.55210576
4RIPK43.11038548
5KDR2.94046864
6SIK32.64319938
7PRPF4B2.49303292
8MINK12.40533577
9CASK2.38178017
10SIK22.33502544
11TTN2.29672435
12TIE111.6319866
13MARK11.90111471
14MAP3K91.83056629
15LIMK11.81357793
16MAP3K41.73310532
17BMPR21.73272633
18PLK21.73220810
19NTRK11.70386206
20MAP2K71.68740524
21TGFBR11.66811101
22LATS21.58058151
23CAMKK11.56477731
24DAPK21.51668572
25MYLK1.48395703
26NTRK21.43423282
27MET1.42101008
28PRKG21.41999336
29FLT31.39551257
30TEC1.39107925
31KSR11.34063574
32CAMKK21.33061032
33TESK11.31676187
34PAK61.31041791
35MAPK131.28898063
36EPHA21.27394348
37PAK31.27058104
38TNK21.25743562
39CDK51.24714782
40DDR21.24355802
41TNIK1.22666774
42ARAF1.22581168
43MAP3K121.20530004
44STK381.11997737
45PTK2B1.11796281
46DMPK1.10792626
47LATS11.10311000
48PAK21.09809621
49GRK51.08601066
50PINK11.04455487
51PAK41.04447728
52RIPK11.03690216
53MAP3K131.02074857
54MAP2K41.01670459
55CAMK2A1.01470461
56GRK70.98161096
57FES0.97679048
58EEF2K0.96406238
59PRKCG0.95030591
60SGK20.94572790
61DAPK10.84736062
62WNK10.84651604
63CSNK1A1L0.84024333
64ERBB30.83851972
65FER0.82965197
66SGK10.82037596
67CSNK1G30.81391777
68CAMK2B0.79983160
69MAP3K20.79711509
70SGK2230.79205389
71SGK4940.79205389
72CSNK1G10.78547094
73KSR20.78128151
74PIK3CG0.73603801
75ICK0.73478027
76CDC42BPA0.72889924
77LMTK20.72434343
78PRKCE0.72312053
79MARK20.72019860
80ITK0.70694345
81BCR0.70299007
82PDGFRB0.69973158
83DAPK30.69755753
84CDK180.69586258
85PDGFRA0.69533448
86PTK20.68107433
87YES10.67282589
88SGK30.67266240
89EPHB20.64861865
90CDK140.64467770
91NEK60.64312291
92PIK3CA0.64294262
93SCYL20.63883032
94MAPKAPK30.62672297
95CDK150.61586853
96RAF10.61326889
97SMG10.60815552
98CAMK10.59785677
99UHMK10.59662973
100PRKD30.59097556
101PRKCH0.58513071
102TRIB30.58219095
103ERBB40.57941353
104CAMK2D0.55274497
105STK110.54680606
106FYN0.53821897
107FGR0.53368263
108MAPK100.52183825
109MAP2K10.51445919
110STK38L0.51054808
111CDK11A0.50838242
112GSK3A0.50772974
113BMX0.49772605
114MAPKAPK50.48976863
115TYRO30.48250078
116ILK0.47521713
117RPS6KA20.46950016
118TRPM70.46169282
119WNK30.45706029
120CDK80.43321861
121ADRBK10.42276887
122TAOK10.42097455
123ROCK10.41364441
124MOS0.40771432
125RET0.40278728
126ADRBK20.40106176
127SRC0.40073952
128CSNK1G20.39178951
129PRKCZ0.38558516
130CSNK1A10.37933799
131EGFR0.36970180
132CAMK1D0.36353881
133RPS6KA30.35575292
134ROCK20.34776935
135MAP3K140.34738043
136OXSR10.34229911
137ZAP700.34217511
138TAOK20.34165472
139INSR0.33696324
140CAMK1G0.33209468
141DYRK20.31018841
142NEK90.29501746
143MTOR0.29235580
144ABL20.27428565
145BRSK10.27126148
146EPHB10.26770970
147PTK60.26659301
148CLK10.25802340
149CDK120.25801913
150MAP2K30.25045731
151PKN20.22987647
152PRKD10.19529553
153IRAK30.18854339
154PRKD20.18262922
155NEK10.15033139
156PDPK10.14634353
157MELK0.14609716
158PAK10.14404622
159CDK90.14012550

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.40647031
2Olfactory transduction_Homo sapiens_hsa047402.58484788
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.43949506
4Morphine addiction_Homo sapiens_hsa050322.41095985
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40210418
6Circadian entrainment_Homo sapiens_hsa047132.39600293
7Synaptic vesicle cycle_Homo sapiens_hsa047212.33502129
8TGF-beta signaling pathway_Homo sapiens_hsa043502.29343245
9Glutamatergic synapse_Homo sapiens_hsa047242.27705025
10Long-term potentiation_Homo sapiens_hsa047202.24401879
11GABAergic synapse_Homo sapiens_hsa047272.22394873
12Amphetamine addiction_Homo sapiens_hsa050312.15234048
13Dopaminergic synapse_Homo sapiens_hsa047281.89307395
14Salivary secretion_Homo sapiens_hsa049701.87022153
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.82060212
16Cocaine addiction_Homo sapiens_hsa050301.74566181
17Renin secretion_Homo sapiens_hsa049241.73212552
18Cholinergic synapse_Homo sapiens_hsa047251.72553292
19* Serotonergic synapse_Homo sapiens_hsa047261.68599273
20Calcium signaling pathway_Homo sapiens_hsa040201.63752046
21Long-term depression_Homo sapiens_hsa047301.61994296
22Oxytocin signaling pathway_Homo sapiens_hsa049211.60445572
23Small cell lung cancer_Homo sapiens_hsa052221.59493607
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.58989965
25* Taste transduction_Homo sapiens_hsa047421.58595482
26Tight junction_Homo sapiens_hsa045301.52993525
27Gastric acid secretion_Homo sapiens_hsa049711.52479165
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46956838
29GnRH signaling pathway_Homo sapiens_hsa049121.46724599
30Insulin secretion_Homo sapiens_hsa049111.43272033
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41140036
32Axon guidance_Homo sapiens_hsa043601.39410486
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39305387
34Gap junction_Homo sapiens_hsa045401.37797302
35Collecting duct acid secretion_Homo sapiens_hsa049661.36829782
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35117286
37* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33779027
38Bladder cancer_Homo sapiens_hsa052191.28844265
39PI3K-Akt signaling pathway_Homo sapiens_hsa041511.28504135
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26626208
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23336467
42Dilated cardiomyopathy_Homo sapiens_hsa054141.22899233
43* cAMP signaling pathway_Homo sapiens_hsa040241.19958368
44Chronic myeloid leukemia_Homo sapiens_hsa052201.19105883
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18073878
46Basal cell carcinoma_Homo sapiens_hsa052171.17224054
47Phototransduction_Homo sapiens_hsa047441.14413913
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10595642
49Pathways in cancer_Homo sapiens_hsa052001.09317876
50Glioma_Homo sapiens_hsa052141.08972937
51N-Glycan biosynthesis_Homo sapiens_hsa005101.08058532
52Hedgehog signaling pathway_Homo sapiens_hsa043401.07602300
53ErbB signaling pathway_Homo sapiens_hsa040121.04622318
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03996639
55MicroRNAs in cancer_Homo sapiens_hsa052061.03316879
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01742886
57Selenocompound metabolism_Homo sapiens_hsa004500.97994020
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97763764
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95499354
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.95015423
61Melanogenesis_Homo sapiens_hsa049160.94602391
62Pancreatic cancer_Homo sapiens_hsa052120.93287148
63Rap1 signaling pathway_Homo sapiens_hsa040150.93195432
64Vibrio cholerae infection_Homo sapiens_hsa051100.89512189
65Renal cell carcinoma_Homo sapiens_hsa052110.87758490
66MAPK signaling pathway_Homo sapiens_hsa040100.87246147
67Estrogen signaling pathway_Homo sapiens_hsa049150.86833356
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83689220
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83427741
70Rheumatoid arthritis_Homo sapiens_hsa053230.83341920
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83179717
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82343148
73Alcoholism_Homo sapiens_hsa050340.81461312
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.80929968
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79889443
76Type II diabetes mellitus_Homo sapiens_hsa049300.79663818
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77808119
78Ras signaling pathway_Homo sapiens_hsa040140.77758532
79Ovarian steroidogenesis_Homo sapiens_hsa049130.77054418
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76062341
81Dorso-ventral axis formation_Homo sapiens_hsa043200.74483593
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72860171
83African trypanosomiasis_Homo sapiens_hsa051430.72344511
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71251986
85Malaria_Homo sapiens_hsa051440.69888029
86Melanoma_Homo sapiens_hsa052180.69395065
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69367858
88Wnt signaling pathway_Homo sapiens_hsa043100.68002150
89Focal adhesion_Homo sapiens_hsa045100.65216070
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64798734
91HIF-1 signaling pathway_Homo sapiens_hsa040660.64783888
92Choline metabolism in cancer_Homo sapiens_hsa052310.64763509
93Inositol phosphate metabolism_Homo sapiens_hsa005620.64719080
94Phagosome_Homo sapiens_hsa041450.64454741
95VEGF signaling pathway_Homo sapiens_hsa043700.64254664
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.62929743
97ECM-receptor interaction_Homo sapiens_hsa045120.62440222
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62212673
99Pancreatic secretion_Homo sapiens_hsa049720.61063718
100Thyroid hormone synthesis_Homo sapiens_hsa049180.59578042
101Chemokine signaling pathway_Homo sapiens_hsa040620.59014664
102Platelet activation_Homo sapiens_hsa046110.58549740
103Non-small cell lung cancer_Homo sapiens_hsa052230.58545982
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58435494
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57052685
106Hippo signaling pathway_Homo sapiens_hsa043900.56285367
107Amoebiasis_Homo sapiens_hsa051460.56274379
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.55158502
109Salmonella infection_Homo sapiens_hsa051320.54647767
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54567684
111Proteoglycans in cancer_Homo sapiens_hsa052050.53502813
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53106347
113Renin-angiotensin system_Homo sapiens_hsa046140.52804083
114Type I diabetes mellitus_Homo sapiens_hsa049400.52697799
115Protein digestion and absorption_Homo sapiens_hsa049740.52679567
116Fatty acid biosynthesis_Homo sapiens_hsa000610.50476961
117Shigellosis_Homo sapiens_hsa051310.47930171
118p53 signaling pathway_Homo sapiens_hsa041150.46567355
119Oocyte meiosis_Homo sapiens_hsa041140.45271331
120Tuberculosis_Homo sapiens_hsa051520.45267995
121Adherens junction_Homo sapiens_hsa045200.43464801
122Mineral absorption_Homo sapiens_hsa049780.43161729
123Prion diseases_Homo sapiens_hsa050200.43160871
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41967152
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41662046
126Colorectal cancer_Homo sapiens_hsa052100.41653841
127Notch signaling pathway_Homo sapiens_hsa043300.41421668
128Endocytosis_Homo sapiens_hsa041440.40611064
129mTOR signaling pathway_Homo sapiens_hsa041500.40595896
130Cardiac muscle contraction_Homo sapiens_hsa042600.40470651
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40336185
132Endometrial cancer_Homo sapiens_hsa052130.39249950

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