HTR1D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)7.24027364
2negative regulation of dendrite morphogenesis (GO:0050774)6.78397694
3peripheral nervous system neuron development (GO:0048935)6.47896829
4neuronal action potential propagation (GO:0019227)6.04748217
5cell migration in hindbrain (GO:0021535)6.00389939
6negative regulation of homotypic cell-cell adhesion (GO:0034111)5.20611789
7negative regulation of dendrite development (GO:2000171)4.99665717
8neuronal action potential (GO:0019228)4.99068667
9calcium-mediated signaling using intracellular calcium source (GO:0035584)4.82943917
10response to pheromone (GO:0019236)4.74478133
11behavioral response to nicotine (GO:0035095)4.53910845
12water-soluble vitamin biosynthetic process (GO:0042364)4.49730503
13fucose catabolic process (GO:0019317)4.42387907
14L-fucose metabolic process (GO:0042354)4.42387907
15L-fucose catabolic process (GO:0042355)4.42387907
16membrane depolarization during action potential (GO:0086010)4.30063300
17inositol phosphate catabolic process (GO:0071545)4.21064550
18innervation (GO:0060384)4.17127856
19protein localization to synapse (GO:0035418)4.16312415
20negative regulation of calcium ion transport into cytosol (GO:0010523)4.07154926
21vocalization behavior (GO:0071625)3.91917848
22protein complex biogenesis (GO:0070271)3.91708389
23negative regulation of cation channel activity (GO:2001258)3.87362861
24regulation of synaptic vesicle exocytosis (GO:2000300)3.86066732
25respiratory chain complex IV assembly (GO:0008535)3.84978195
26cerebellar Purkinje cell differentiation (GO:0021702)3.84461161
27synaptic vesicle maturation (GO:0016188)3.84180046
28kidney morphogenesis (GO:0060993)3.80058389
29positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.77939884
30glutamate secretion (GO:0014047)3.76577284
31synaptic vesicle exocytosis (GO:0016079)3.74274966
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.71847877
33NADH dehydrogenase complex assembly (GO:0010257)3.71847877
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.71847877
35mitochondrial respiratory chain complex assembly (GO:0033108)3.71238006
36negative regulation of heart rate (GO:0010459)3.68282480
37neuron cell-cell adhesion (GO:0007158)3.65492741
38regulation of platelet aggregation (GO:0090330)3.62725990
39cytochrome complex assembly (GO:0017004)3.62709741
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.59178826
41regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.57889151
42establishment of mitochondrion localization (GO:0051654)3.54701011
43regulation of neuron projection regeneration (GO:0070570)3.49877289
44regulation of axon regeneration (GO:0048679)3.49877289
45negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.48330091
46protein-cofactor linkage (GO:0018065)3.47781277
47regulation of short-term neuronal synaptic plasticity (GO:0048172)3.47513789
48regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.45717956
49regulation of protein kinase A signaling (GO:0010738)3.45602532
50regulation of mitotic spindle checkpoint (GO:1903504)3.42262105
51regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.42262105
52intermediate filament organization (GO:0045109)3.39649003
53action potential (GO:0001508)3.35799862
54energy coupled proton transport, down electrochemical gradient (GO:0015985)3.35609920
55ATP synthesis coupled proton transport (GO:0015986)3.35609920
56presynaptic membrane assembly (GO:0097105)3.33450843
57regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.32416396
58regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.31952553
59cellular ketone body metabolic process (GO:0046950)3.31054364
60cell communication by electrical coupling (GO:0010644)3.30315306
61detection of temperature stimulus (GO:0016048)3.29899992
62neural tube formation (GO:0001841)3.28705485
63positive regulation of mitochondrial fission (GO:0090141)3.28601232
64proline transport (GO:0015824)3.28365830
65mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.26296823
66regulation of synaptic vesicle transport (GO:1902803)3.25580029
67detection of mechanical stimulus involved in sensory perception (GO:0050974)3.23652976
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.23296508
69peptidyl-histidine modification (GO:0018202)3.22841100
70mannosylation (GO:0097502)3.21149337
71protein polyglutamylation (GO:0018095)3.20793647
72neuromuscular process controlling posture (GO:0050884)3.20427629
73negative regulation of telomere maintenance (GO:0032205)3.20160976
74platelet dense granule organization (GO:0060155)3.20101601
75acrosome reaction (GO:0007340)3.18764070
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.18551332
77presynaptic membrane organization (GO:0097090)3.16813175
78regulation of NFAT protein import into nucleus (GO:0051532)3.16252969
79mitochondrion transport along microtubule (GO:0047497)3.15908918
80establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.15908918
81striatum development (GO:0021756)3.15397571
82regulation of cell communication by electrical coupling (GO:0010649)3.15105746
83positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.14925742
84positive regulation of potassium ion transmembrane transport (GO:1901381)3.14391780
85regulation of relaxation of muscle (GO:1901077)3.14296198
86rRNA catabolic process (GO:0016075)3.12902418
87axon development (GO:0061564)3.12785160
88ketone body metabolic process (GO:1902224)3.09195620
89detection of temperature stimulus involved in sensory perception (GO:0050961)3.08841364
90detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.08841364
91potassium ion export (GO:0071435)3.08555726
92DNA deamination (GO:0045006)3.07656130
93pseudouridine synthesis (GO:0001522)3.07560950
94neuron fate specification (GO:0048665)3.06138254
95establishment of protein localization to mitochondrial membrane (GO:0090151)3.03046731
96calcium ion-dependent exocytosis (GO:0017156)3.02590292
97synapse assembly (GO:0007416)3.02459911
98detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.02299431
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00802252
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00802252
101regulation of cell maturation (GO:1903429)3.00728629
102negative regulation of synaptic transmission, GABAergic (GO:0032229)3.00704606
103preassembly of GPI anchor in ER membrane (GO:0016254)2.97382977
104retinal ganglion cell axon guidance (GO:0031290)2.96177165
105proteasome assembly (GO:0043248)2.95243004
106postsynaptic membrane organization (GO:0001941)2.95077137
107membrane assembly (GO:0071709)2.93864828
108DNA double-strand break processing (GO:0000729)2.92648710
109regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.92200425
110positive regulation of synaptic transmission, GABAergic (GO:0032230)2.90731551
111regulation of nuclear cell cycle DNA replication (GO:0033262)2.90437513
112behavioral response to pain (GO:0048266)2.90061509
113cell communication involved in cardiac conduction (GO:0086065)2.89501044
114regulation of neuronal synaptic plasticity (GO:0048168)2.86862572
115negative regulation of DNA-dependent DNA replication (GO:2000104)2.84521102
116neurotransmitter secretion (GO:0007269)2.83097895
117activation of protein kinase A activity (GO:0034199)2.82403496
118omega-hydroxylase P450 pathway (GO:0097267)2.82153835
119membrane depolarization (GO:0051899)2.81370686
120neurotransmitter-gated ion channel clustering (GO:0072578)2.80656693
121regulation of sodium ion transmembrane transporter activity (GO:2000649)2.80596240
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80443851
123cranial nerve development (GO:0021545)2.80227332
124transcription elongation from RNA polymerase III promoter (GO:0006385)2.80057735
125termination of RNA polymerase III transcription (GO:0006386)2.80057735
126pyrimidine nucleobase catabolic process (GO:0006208)2.79148205
127maturation of 5.8S rRNA (GO:0000460)2.78685526
128electron transport chain (GO:0022900)2.77917620
129sodium ion transmembrane transport (GO:0035725)2.77915452
130negative regulation of membrane potential (GO:0045837)2.77274974
131regulation of mitochondrial fission (GO:0090140)2.76977636
132dopamine transport (GO:0015872)2.76789062
133regulation of glucokinase activity (GO:0033131)2.76544968
134regulation of hexokinase activity (GO:1903299)2.76544968
135protein neddylation (GO:0045116)2.76113560
136DNA damage response, detection of DNA damage (GO:0042769)2.74700461
137regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74092033
138exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74088110
139response to acidic pH (GO:0010447)2.73880642
140suckling behavior (GO:0001967)2.72940599
141tRNA processing (GO:0008033)2.72480616
142sodium ion homeostasis (GO:0055078)2.71908810
143positive regulation of amino acid transport (GO:0051957)2.71788971
144positive regulation of potassium ion transport (GO:0043268)2.71386470
145negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.71372726
146negative regulation of calcium ion transmembrane transport (GO:1903170)2.71372726
147respiratory electron transport chain (GO:0022904)2.70898636
148axon cargo transport (GO:0008088)2.70738480
149positive regulation of axon extension (GO:0045773)2.70594191
150regulation of translational termination (GO:0006449)2.68807037
151cilium morphogenesis (GO:0060271)2.66932776
152piRNA metabolic process (GO:0034587)2.66659828
153neuromuscular process (GO:0050905)2.66447363
154indolalkylamine metabolic process (GO:0006586)2.65865858
155peripheral nervous system development (GO:0007422)2.65620873
156anterograde synaptic vesicle transport (GO:0048490)2.64702506
157inositol phosphate dephosphorylation (GO:0046855)2.64435090
158phosphorylated carbohydrate dephosphorylation (GO:0046838)2.64435090
159nonmotile primary cilium assembly (GO:0035058)2.64316605
160somite development (GO:0061053)2.61907611
161replication fork processing (GO:0031297)2.59485646
162reciprocal DNA recombination (GO:0035825)2.57546924
163reciprocal meiotic recombination (GO:0007131)2.57546924
164nucleobase catabolic process (GO:0046113)2.55803273
165regulation of hippo signaling (GO:0035330)2.55457147
166photoreceptor cell development (GO:0042461)2.54468301
167cornea development in camera-type eye (GO:0061303)2.54370109
168limb bud formation (GO:0060174)2.53627824
169L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.53284585
170regulation of mitochondrial translation (GO:0070129)2.51601488
171cell fate commitment involved in formation of primary germ layer (GO:0060795)2.50623202
172regulation of cilium movement (GO:0003352)2.48310070
173epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.47942277
174single strand break repair (GO:0000012)2.45600430
175organelle disassembly (GO:1903008)2.45426772
176kynurenine metabolic process (GO:0070189)2.44885708
177signal peptide processing (GO:0006465)2.44284735
178sulfation (GO:0051923)2.42392540
179intraciliary transport (GO:0042073)2.41834362
180negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.41524634
181negative regulation of translation, ncRNA-mediated (GO:0040033)2.41524634
182regulation of translation, ncRNA-mediated (GO:0045974)2.41524634
183tRNA modification (GO:0006400)2.41397571
184otic vesicle formation (GO:0030916)2.40958026
185detection of light stimulus involved in sensory perception (GO:0050962)2.40897731
186detection of light stimulus involved in visual perception (GO:0050908)2.40897731
187G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.39576280
188regulation of gene silencing by RNA (GO:0060966)2.39486895
189regulation of posttranscriptional gene silencing (GO:0060147)2.39486895
190regulation of gene silencing by miRNA (GO:0060964)2.39486895
191somatic hypermutation of immunoglobulin genes (GO:0016446)2.39262435
192somatic diversification of immune receptors via somatic mutation (GO:0002566)2.39262435
193chaperone-mediated protein transport (GO:0072321)2.39175425
194ubiquinone biosynthetic process (GO:0006744)2.38216112
195RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.37837189
196recombinational repair (GO:0000725)2.36774584
197negative regulation of transcription regulatory region DNA binding (GO:2000678)2.35162094
198indole-containing compound catabolic process (GO:0042436)2.34659228
199indolalkylamine catabolic process (GO:0046218)2.34659228
200tryptophan catabolic process (GO:0006569)2.34659228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.69194323
2ZNF274_21170338_ChIP-Seq_K562_Hela4.27532194
3TAF15_26573619_Chip-Seq_HEK293_Human3.97773792
4EZH2_22144423_ChIP-Seq_EOC_Human3.94871995
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09170081
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02995112
7VDR_22108803_ChIP-Seq_LS180_Human3.00544322
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97638750
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.95577465
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94359265
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92331488
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.84152465
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.71662233
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62760657
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61731632
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61731632
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.58239913
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.55782382
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34874270
20* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31605091
21EWS_26573619_Chip-Seq_HEK293_Human2.30755187
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29927266
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26392437
24FUS_26573619_Chip-Seq_HEK293_Human2.25428972
25REST_21632747_ChIP-Seq_MESCs_Mouse2.23114630
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.20484726
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14720394
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07192669
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.04944646
30* P300_19829295_ChIP-Seq_ESCs_Human2.04747093
31SMAD4_21799915_ChIP-Seq_A2780_Human2.04662850
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.03836693
33MYC_18940864_ChIP-ChIP_HL60_Human1.98137067
34ELK1_19687146_ChIP-ChIP_HELA_Human1.97363910
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.97049782
36AR_21572438_ChIP-Seq_LNCaP_Human1.93188697
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91984071
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88437072
39* EZH2_27294783_Chip-Seq_ESCs_Mouse1.84548238
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82285754
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.77690023
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.76301781
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74525452
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.74023430
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73218143
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69087934
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67597082
48* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.65251414
49RNF2_27304074_Chip-Seq_NSC_Mouse1.63386167
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62326647
51VDR_23849224_ChIP-Seq_CD4+_Human1.62042660
52ER_23166858_ChIP-Seq_MCF-7_Human1.61371271
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60316894
54TP53_22573176_ChIP-Seq_HFKS_Human1.58711132
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58421901
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56825920
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55731810
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.55279102
59AR_25329375_ChIP-Seq_VCAP_Human1.54920794
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53998861
61* STAT3_23295773_ChIP-Seq_U87_Human1.53119663
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.52583183
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50923498
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50918449
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50890288
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.48887805
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.48811544
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48059426
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47173388
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47089522
71IRF1_19129219_ChIP-ChIP_H3396_Human1.46909740
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46532499
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43303621
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42530181
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.40778355
76IGF1R_20145208_ChIP-Seq_DFB_Human1.39878259
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39751500
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37315910
79JUN_21703547_ChIP-Seq_K562_Human1.36941134
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35644348
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33917383
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33805599
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.32594081
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31902758
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.31562527
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29436247
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29302974
88CBP_20019798_ChIP-Seq_JUKART_Human1.29302974
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.27332030
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.27238091
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25418081
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.25418081
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25130347
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.24880712
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24681932
96FOXP3_21729870_ChIP-Seq_TREG_Human1.23859352
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23342173
98NANOG_19829295_ChIP-Seq_ESCs_Human1.23037101
99SOX2_19829295_ChIP-Seq_ESCs_Human1.23037101
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.22205551
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.21785438
102AHR_22903824_ChIP-Seq_MCF-7_Human1.19497439
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.19481141
104* AR_20517297_ChIP-Seq_VCAP_Human1.19363047
105P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19023836
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.17832676
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.17819059
108PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17340727
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16257047
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16104897
111KDM2B_26808549_Chip-Seq_REH_Human1.15372338
112P53_22387025_ChIP-Seq_ESCs_Mouse1.15147430
113* TCF4_23295773_ChIP-Seq_U87_Human1.14970821
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14809953
115DROSHA_22980978_ChIP-Seq_HELA_Human1.14715587
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14605525
117RUNX2_22187159_ChIP-Seq_PCA_Human1.14223957
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14132579
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13551523
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.13472241
121NCOR_22424771_ChIP-Seq_293T_Human1.12800204
122* GATA3_21878914_ChIP-Seq_MCF-7_Human1.11527561
123EZH2_27294783_Chip-Seq_NPCs_Mouse1.11328806
124* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10302068
125NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10273063
126PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09526147
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09158769
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09158769
129HOXB7_26014856_ChIP-Seq_BT474_Human1.08199723
130SOX2_16153702_ChIP-ChIP_HESCs_Human1.07872828
131PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07276744
132PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05725002
133TCF4_22108803_ChIP-Seq_LS180_Human1.03872859
134ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03419729
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03342096
136TP53_18474530_ChIP-ChIP_U2OS_Human1.03271208
137KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03269254
138CMYC_18555785_Chip-Seq_ESCs_Mouse1.02471955
139AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01334061
140E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01179199
141* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00550815
142BCAT_22108803_ChIP-Seq_LS180_Human1.00165012
143FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99914431
144RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99885446
145CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99857109
146RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98789296
147FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98188808
148AR_19668381_ChIP-Seq_PC3_Human0.97962268
149CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97377525
150MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96989055
151TAL1_26923725_Chip-Seq_HPCs_Mouse0.96216611
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96059237
153* P300_18555785_Chip-Seq_ESCs_Mouse0.95281597
154CDX2_22108803_ChIP-Seq_LS180_Human0.94733046
155STAT3_18555785_Chip-Seq_ESCs_Mouse0.94251338
156MYC_19829295_ChIP-Seq_ESCs_Human0.94193251
157NANOG_16153702_ChIP-ChIP_HESCs_Human0.90345045
158CRX_20693478_ChIP-Seq_RETINA_Mouse0.89818254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity6.87794931
2MP0002735_abnormal_chemical_nociception4.78449142
3MP0004270_analgesia4.73032275
4MP0004858_abnormal_nervous_system3.72758997
5MP0001968_abnormal_touch/_nociception3.69071034
6MP0006292_abnormal_olfactory_placode3.63274092
7MP0003880_abnormal_central_pattern3.43040112
8MP0003183_abnormal_peptide_metabolism3.20392815
9MP0002734_abnormal_mechanical_nocicepti3.15102757
10MP0006276_abnormal_autonomic_nervous3.12022886
11MP0002102_abnormal_ear_morphology3.01261615
12MP0004859_abnormal_synaptic_plasticity2.97689913
13MP0002736_abnormal_nociception_after2.96796039
14MP0008877_abnormal_DNA_methylation2.95528352
15MP0002163_abnormal_gland_morphology2.68772998
16MP0009046_muscle_twitch2.60270825
17MP0003635_abnormal_synaptic_transmissio2.46723377
18MP0002733_abnormal_thermal_nociception2.44389026
19MP0001188_hyperpigmentation2.41868144
20MP0002272_abnormal_nervous_system2.34423269
21MP0003718_maternal_effect2.15910160
22MP0001970_abnormal_pain_threshold2.15504040
23MP0009745_abnormal_behavioral_response2.13708142
24MP0002067_abnormal_sensory_capabilities2.08379671
25MP0006072_abnormal_retinal_apoptosis2.07299615
26MP0002938_white_spotting2.00113557
27MP0002064_seizures1.97929932
28MP0002184_abnormal_innervation1.97019374
29MP0003890_abnormal_embryonic-extraembry1.94837330
30MP0008260_abnormal_autophagy1.93129764
31MP0002063_abnormal_learning/memory/cond1.92063957
32MP0002837_dystrophic_cardiac_calcinosis1.91374779
33MP0008058_abnormal_DNA_repair1.90757650
34MP0008875_abnormal_xenobiotic_pharmacok1.89162617
35MP0004133_heterotaxia1.86711563
36MP0001486_abnormal_startle_reflex1.86008534
37MP0002572_abnormal_emotion/affect_behav1.84542944
38MP0004147_increased_porphyrin_level1.83487090
39MP0005379_endocrine/exocrine_gland_phen1.82131285
40MP0003195_calcinosis1.80713115
41MP0001984_abnormal_olfaction1.76200208
42MP0005084_abnormal_gallbladder_morpholo1.69959820
43MP0004142_abnormal_muscle_tone1.69387048
44MP0002751_abnormal_autonomic_nervous1.66296983
45MP0003787_abnormal_imprinting1.63485892
46MP0005646_abnormal_pituitary_gland1.63024962
47MP0002254_reproductive_system_inflammat1.62448468
48MP0003879_abnormal_hair_cell1.60141496
49MP0004043_abnormal_pH_regulation1.57028222
50MP0000778_abnormal_nervous_system1.53251388
51MP0001501_abnormal_sleep_pattern1.53105567
52MP0005253_abnormal_eye_physiology1.52944535
53MP0002822_catalepsy1.52919575
54MP0000955_abnormal_spinal_cord1.50895118
55MP0000569_abnormal_digit_pigmentation1.50780149
56MP0004811_abnormal_neuron_physiology1.50293197
57MP0005423_abnormal_somatic_nervous1.49642368
58MP0009379_abnormal_foot_pigmentation1.49475955
59MP0002876_abnormal_thyroid_physiology1.47776411
60MP0004885_abnormal_endolymph1.47549388
61MP0003329_amyloid_beta_deposits1.42764905
62MP0001529_abnormal_vocalization1.40090983
63MP0009697_abnormal_copulation1.39994899
64MP0002638_abnormal_pupillary_reflex1.39436216
65MP0005386_behavior/neurological_phenoty1.35488816
66MP0004924_abnormal_behavior1.35488816
67MP0002229_neurodegeneration1.33711530
68MP0001293_anophthalmia1.33618296
69MP0002882_abnormal_neuron_morphology1.32156959
70MP0005085_abnormal_gallbladder_physiolo1.31988922
71MP0005409_darkened_coat_color1.30983974
72MP0000427_abnormal_hair_cycle1.29591905
73MP0008569_lethality_at_weaning1.27935234
74MP0003252_abnormal_bile_duct1.27830455
75MP0000749_muscle_degeneration1.27631436
76MP0002557_abnormal_social/conspecific_i1.21577213
77MP0000647_abnormal_sebaceous_gland1.21328369
78MP0002277_abnormal_respiratory_mucosa1.21237606
79MP0003011_delayed_dark_adaptation1.17031761
80MP0001440_abnormal_grooming_behavior1.15436688
81MP0003878_abnormal_ear_physiology1.12889018
82MP0005377_hearing/vestibular/ear_phenot1.12889018
83MP0003283_abnormal_digestive_organ1.12319138
84MP0001348_abnormal_lacrimal_gland1.11303401
85MP0002752_abnormal_somatic_nervous1.07597767
86MP0005195_abnormal_posterior_eye1.07288558
87MP0005174_abnormal_tail_pigmentation1.07045864
88MP0002066_abnormal_motor_capabilities/c1.06330434
89MP0008789_abnormal_olfactory_epithelium1.06287802
90MP0005410_abnormal_fertilization1.04987513
91MP0000751_myopathy1.04775571
92MP0003121_genomic_imprinting1.04358914
93MP0001905_abnormal_dopamine_level1.01403852
94MP0005075_abnormal_melanosome_morpholog1.01387324
95MP0002160_abnormal_reproductive_system1.00078020
96MP0001502_abnormal_circadian_rhythm0.99930588
97MP0001485_abnormal_pinna_reflex0.99541575
98MP0005332_abnormal_amino_acid0.98657315
99MP0003136_yellow_coat_color0.97545780
100MP0002928_abnormal_bile_duct0.97541627
101MP0000015_abnormal_ear_pigmentation0.97511190
102MP0003937_abnormal_limbs/digits/tail_de0.95951947
103MP0005171_absent_coat_pigmentation0.95549238
104MP0003119_abnormal_digestive_system0.95022979
105MP0002234_abnormal_pharynx_morphology0.94197592
106MP0005645_abnormal_hypothalamus_physiol0.94123171
107MP0000383_abnormal_hair_follicle0.93512496
108MP0001963_abnormal_hearing_physiology0.93238754
109MP0005187_abnormal_penis_morphology0.92039827
110MP0003567_abnormal_fetal_cardiomyocyte0.90583140
111MP0004215_abnormal_myocardial_fiber0.90226945
112MP0001764_abnormal_homeostasis0.90148642
113MP0002653_abnormal_ependyma_morphology0.87206105
114MP0004742_abnormal_vestibular_system0.86715663
115MP0002138_abnormal_hepatobiliary_system0.86640346
116MP0001286_abnormal_eye_development0.85744587
117MP0001919_abnormal_reproductive_system0.85369113
118MP0001929_abnormal_gametogenesis0.84987471
119MP0002210_abnormal_sex_determination0.84786232
120MP0002009_preneoplasia0.84471422
121MP0005360_urolithiasis0.84430288
122MP0001299_abnormal_eye_distance/0.84098764
123MP0003693_abnormal_embryo_hatching0.83215690
124MP0000049_abnormal_middle_ear0.83117616
125MP0010094_abnormal_chromosome_stability0.83065424
126MP0003698_abnormal_male_reproductive0.82633449
127MP0002909_abnormal_adrenal_gland0.81424133
128MP0004145_abnormal_muscle_electrophysio0.80103065
129MP0003634_abnormal_glial_cell0.79415673
130MP0000372_irregular_coat_pigmentation0.76728385
131MP0003633_abnormal_nervous_system0.76098787
132MP0003631_nervous_system_phenotype0.72332339
133MP0008872_abnormal_physiological_respon0.69873803
134MP0004085_abnormal_heartbeat0.68512490
135MP0008874_decreased_physiological_sensi0.68012804
136MP0000026_abnormal_inner_ear0.65945182
137MP0001664_abnormal_digestion0.64315478
138MP0000920_abnormal_myelination0.64303837
139MP0005535_abnormal_body_temperature0.63027370
140MP0002152_abnormal_brain_morphology0.59419699
141MP0006036_abnormal_mitochondrial_physio0.57071874
142MP0002069_abnormal_eating/drinking_beha0.56954462
143MP0005551_abnormal_eye_electrophysiolog0.56416142
144MP0003646_muscle_fatigue0.54628426
145MP0009780_abnormal_chondrocyte_physiolo0.54292046
146MP0000604_amyloidosis0.53108854
147MP0005389_reproductive_system_phenotype0.53098715
148MP0004484_altered_response_of0.50598943
149MP0006035_abnormal_mitochondrial_morpho0.50051671
150MP0003315_abnormal_perineum_morphology0.49937783
151MP0001270_distended_abdomen0.49897229
152MP0005394_taste/olfaction_phenotype0.48334441
153MP0005499_abnormal_olfactory_system0.48334441
154MP0005083_abnormal_biliary_tract0.47395883
155MP0000631_abnormal_neuroendocrine_gland0.47124681

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.73685750
2Ulnar claw (HP:0001178)6.36525471
3Focal motor seizures (HP:0011153)5.72435013
4Febrile seizures (HP:0002373)5.25561971
5Pheochromocytoma (HP:0002666)5.14903234
6Action tremor (HP:0002345)4.76313934
7Neuroendocrine neoplasm (HP:0100634)4.68184753
8Atonic seizures (HP:0010819)4.48352174
9Hypothermia (HP:0002045)4.36047370
10Thoracolumbar scoliosis (HP:0002944)4.13264525
11Pancreatic cysts (HP:0001737)3.74045268
12Fetal akinesia sequence (HP:0001989)3.71004522
13Focal seizures (HP:0007359)3.67348154
14Type II lissencephaly (HP:0007260)3.65890477
15Progressive cerebellar ataxia (HP:0002073)3.63536336
16Termporal pattern (HP:0011008)3.60981266
17Insidious onset (HP:0003587)3.60981266
18Molar tooth sign on MRI (HP:0002419)3.59483586
19Abnormality of midbrain morphology (HP:0002418)3.59483586
20Pancreatic fibrosis (HP:0100732)3.54915485
21Submucous cleft hard palate (HP:0000176)3.36080233
22Steppage gait (HP:0003376)3.25668254
23Nephronophthisis (HP:0000090)3.17764315
24Abnormality of the renal cortex (HP:0011035)3.16519751
25Congenital stationary night blindness (HP:0007642)3.13412652
26True hermaphroditism (HP:0010459)3.10362207
27Vertebral arch anomaly (HP:0008438)3.05678582
28J-shaped sella turcica (HP:0002680)3.00529134
29Diastasis recti (HP:0001540)2.96274232
30Absence seizures (HP:0002121)2.89871116
31Scanning speech (HP:0002168)2.83407167
32Bradycardia (HP:0001662)2.79552252
33Abnormality of the renal medulla (HP:0100957)2.79421713
34Distal arthrogryposis (HP:0005684)2.78495604
35Neoplasm of the peripheral nervous system (HP:0100007)2.76920115
36Pendular nystagmus (HP:0012043)2.75668440
37Epileptic encephalopathy (HP:0200134)2.74884644
38Optic nerve hypoplasia (HP:0000609)2.68843255
39Foot dorsiflexor weakness (HP:0009027)2.67266943
40Abnormality of pain sensation (HP:0010832)2.67102511
41Impaired pain sensation (HP:0007328)2.67102511
42Renal cortical cysts (HP:0000803)2.66975010
43Generalized tonic-clonic seizures (HP:0002069)2.65925833
44Hepatic necrosis (HP:0002605)2.65143386
45Medial flaring of the eyebrow (HP:0010747)2.64941978
46Gaze-evoked nystagmus (HP:0000640)2.62907339
47Hypoplasia of the pons (HP:0012110)2.61820443
48Segmental peripheral demyelination/remyelination (HP:0003481)2.60676403
49Abnormality of the pons (HP:0007361)2.60388431
50Tubular atrophy (HP:0000092)2.55141680
51Septo-optic dysplasia (HP:0100842)2.54960366
52Dialeptic seizures (HP:0011146)2.54658898
53Akinesia (HP:0002304)2.54237892
54Hyperventilation (HP:0002883)2.53938661
55Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.53590112
56Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.53090901
57Poor suck (HP:0002033)2.51184563
58Acute necrotizing encephalopathy (HP:0006965)2.50236678
59Abnormality of the lumbar spine (HP:0100712)2.49422028
60Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.48893491
61Truncal ataxia (HP:0002078)2.47304969
62Cerebellar dysplasia (HP:0007033)2.47092846
63Abnormal rod and cone electroretinograms (HP:0008323)2.45207706
64Carpal bone hypoplasia (HP:0001498)2.43187654
65Decreased motor nerve conduction velocity (HP:0003431)2.41882047
66Abolished electroretinogram (ERG) (HP:0000550)2.41302285
67Lissencephaly (HP:0001339)2.40603185
68Hypercortisolism (HP:0001578)2.40251531
69Methylmalonic acidemia (HP:0002912)2.38866043
70Supranuclear gaze palsy (HP:0000605)2.37303409
71Abnormality of the labia minora (HP:0012880)2.35631208
72Hyperglycinuria (HP:0003108)2.35426375
73Sclerocornea (HP:0000647)2.32827608
74Bilateral microphthalmos (HP:0007633)2.30459430
75Decreased muscle mass (HP:0003199)2.30306074
76Abnormality of the foot musculature (HP:0001436)2.29653397
77Progressive macrocephaly (HP:0004481)2.29580729
78Ankle clonus (HP:0011448)2.27921433
79Hammertoe (HP:0001765)2.27772063
80Anxiety (HP:0000739)2.26892271
81Methylmalonic aciduria (HP:0012120)2.26349433
82Lipid accumulation in hepatocytes (HP:0006561)2.25734507
83Retinal dysplasia (HP:0007973)2.24024709
84Abnormality of the vocal cords (HP:0008777)2.23007067
85Abnormality of glycolipid metabolism (HP:0010969)2.22741535
86Abnormality of liposaccharide metabolism (HP:0010968)2.22741535
87Abnormality of glycosphingolipid metabolism (HP:0004343)2.22741535
88Abnormal drinking behavior (HP:0030082)2.22393619
89Polydipsia (HP:0001959)2.22393619
90Attenuation of retinal blood vessels (HP:0007843)2.21695770
91Increased hepatocellular lipid droplets (HP:0006565)2.20942736
92Cystic liver disease (HP:0006706)2.19639305
93Intestinal atresia (HP:0011100)2.19118294
94Abnormal mitochondria in muscle tissue (HP:0008316)2.18086417
95Inability to walk (HP:0002540)2.16164041
96Hyperglycinemia (HP:0002154)2.15803271
97Specific learning disability (HP:0001328)2.14415770
98Cerebral edema (HP:0002181)2.14172824
99Testicular neoplasm (HP:0010788)2.13836823
100Congenital, generalized hypertrichosis (HP:0004540)2.12363939
101Abnormal hair whorl (HP:0010721)2.11787253
102Amblyopia (HP:0000646)2.11531386
103Distal sensory impairment (HP:0002936)2.11268885
104Absent rod-and cone-mediated responses on ERG (HP:0007688)2.11012537
105Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10117401
106Abnormality of alanine metabolism (HP:0010916)2.10117401
107Hyperalaninemia (HP:0003348)2.10117401
108Gastrointestinal atresia (HP:0002589)2.09935479
109Mitochondrial inheritance (HP:0001427)2.09687063
110Aplasia/Hypoplasia of the spleen (HP:0010451)2.08501492
111Progressive external ophthalmoplegia (HP:0000590)2.07516900
112Hepatocellular necrosis (HP:0001404)2.06847918
113Optic disc pallor (HP:0000543)2.06642179
114Meckel diverticulum (HP:0002245)2.05942402
115Urinary bladder sphincter dysfunction (HP:0002839)2.05656432
116Abnormality of the ileum (HP:0001549)2.04850677
117Failure to thrive in infancy (HP:0001531)2.01156582
118Aqueductal stenosis (HP:0002410)2.01074257
119Progressive inability to walk (HP:0002505)2.01039911
120Impaired vibration sensation in the lower limbs (HP:0002166)2.00309289
121Gait imbalance (HP:0002141)1.99921868
122Chin dimple (HP:0010751)1.99844965
123Agitation (HP:0000713)1.99522276
124Colon cancer (HP:0003003)1.99050625
125Aplasia/Hypoplasia of the uvula (HP:0010293)1.98908998
126Menstrual irregularities (HP:0000858)1.98716527
127Abnormality of glycine metabolism (HP:0010895)1.98431129
128Abnormality of serine family amino acid metabolism (HP:0010894)1.98431129
129Abnormal biliary tract physiology (HP:0012439)1.98154605
130Bile duct proliferation (HP:0001408)1.98154605
131Onion bulb formation (HP:0003383)1.98048561
132Slow saccadic eye movements (HP:0000514)1.97389293
133Broad alveolar ridges (HP:0000187)1.96359820
134Increased corneal curvature (HP:0100692)1.95933637
135Keratoconus (HP:0000563)1.95933637
1363-Methylglutaconic aciduria (HP:0003535)1.95556098
137Congenital primary aphakia (HP:0007707)1.95510096
138Beaking of vertebral bodies (HP:0004568)1.95317274
139Acute encephalopathy (HP:0006846)1.94954962
140Esotropia (HP:0000565)1.94276273
141Generalized hypotonia (HP:0001290)1.93954212
142Palpitations (HP:0001962)1.93724101
143Diminished movement (HP:0002374)1.92685719
144Chronic hepatic failure (HP:0100626)1.92219326
145Postural tremor (HP:0002174)1.91705544
146Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.91514614
147Abnormality of secondary sexual hair (HP:0009888)1.91360355
148Abnormality of the axillary hair (HP:0100134)1.91360355
149Urinary urgency (HP:0000012)1.91335693
150Pachygyria (HP:0001302)1.91089922
151Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.91066560
152Myotonia (HP:0002486)1.89953544
153Sensory axonal neuropathy (HP:0003390)1.89730135
154Cerebral hemorrhage (HP:0001342)1.89185949
155Stomach cancer (HP:0012126)1.88006716
156Increased serum lactate (HP:0002151)1.88005676
157Genital tract atresia (HP:0001827)1.87747303
158Increased CSF lactate (HP:0002490)1.87559001
159Palpebral edema (HP:0100540)1.87024851
160Asplenia (HP:0001746)1.86116661
161Impaired vibratory sensation (HP:0002495)1.84324147
162Polyuria (HP:0000103)1.83676433
163Aplasia/Hypoplasia of the tongue (HP:0010295)1.83407805
164Ventricular fibrillation (HP:0001663)1.80602182
165Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80491907
166Hypoplasia of the brainstem (HP:0002365)1.80491907
167Abnormality of vitamin B metabolism (HP:0004340)1.80047739
168Nephrogenic diabetes insipidus (HP:0009806)1.79980597
169Vaginal atresia (HP:0000148)1.78943101
170Depression (HP:0000716)1.78305565
171Type I transferrin isoform profile (HP:0003642)1.77640286
172Delayed gross motor development (HP:0002194)1.77490298
173Lethargy (HP:0001254)1.76498409
174Patellar aplasia (HP:0006443)1.74616117
175Anencephaly (HP:0002323)1.74009819
176Absent thumb (HP:0009777)1.72245019
177Anophthalmia (HP:0000528)1.71113759
178Bony spicule pigmentary retinopathy (HP:0007737)1.71006154
179Abnormal protein glycosylation (HP:0012346)1.70195552
180Abnormal glycosylation (HP:0012345)1.70195552
181Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70195552
182Abnormal protein N-linked glycosylation (HP:0012347)1.70195552
183Hypomagnesemia (HP:0002917)1.70076243
184Dandy-Walker malformation (HP:0001305)1.70010209
185Abnormality of the vitamin B12 metabolism (HP:0004341)1.69619487
186Birth length less than 3rd percentile (HP:0003561)1.69432084
187Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.69127256
188Abnormality of aspartate family amino acid metabolism (HP:0010899)1.68738172

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.03824234
2SIK34.89278595
3NTRK33.91669331
4MINK13.50980951
5BMPR1B3.20705828
6MAP3K122.89239273
7ZAK2.78359030
8WNK32.76215933
9NUAK12.67512760
10LMTK22.65375935
11MAPKAPK32.56962497
12MAP2K72.54784815
13NEK92.48702843
14MAP4K22.28829682
15ACVR1B2.23971197
16BCR2.22614920
17AKT32.09136858
18VRK22.01169711
19LATS21.98927102
20STK161.89492714
21MAP3K41.89270605
22MAP3K91.82854262
23INSRR1.79273735
24LIMK11.78979945
25BCKDK1.77387986
26MAPK131.76465508
27DYRK21.76415670
28SGK21.72324978
29TLK11.71143225
30TRIM281.57742653
31MAP2K41.55464044
32NTRK11.54313447
33OXSR11.52584805
34PHKG11.49227503
35PHKG21.49227503
36ARAF1.44875077
37VRK11.42632554
38SGK2231.41813365
39SGK4941.41813365
40TNK21.40876938
41PLK31.36668182
42WNK11.34979971
43ERBB41.32015720
44EIF2AK31.28772323
45SRPK11.27950966
46PRPF4B1.23332496
47TGFBR11.19792675
48MUSK1.19472676
49MKNK11.18263158
50TAOK31.15095749
51BRSK21.14255502
52KSR11.13367130
53STK391.12231983
54TAF11.11658957
55FGFR21.08875472
56SGK31.07507757
57CAMKK21.06323147
58MKNK21.05110553
59GRK51.02965976
60CSNK1G11.02149306
61PLK21.00212997
62FER0.98564962
63TNIK0.97255162
64BUB10.96244613
65EPHA40.95936461
66PLK40.93826440
67ERBB30.92576896
68CDK50.91289940
69TIE10.91095730
70CAMKK10.89217069
71MARK10.88239399
72WNK40.87664680
73DAPK20.87312198
74DAPK10.86679170
75PRKCG0.86341815
76RPS6KA20.85905611
77YES10.84422923
78CSNK1A1L0.83611998
79CAMK2D0.82929718
80PINK10.82625760
81RET0.80663133
82PAK30.74189255
83PLK10.73196577
84MST40.72059757
85FES0.71793832
86MAP2K60.71133987
87PRKCI0.70814986
88WEE10.69748491
89MAPKAPK50.68957525
90TSSK60.66470488
91BRAF0.66432900
92PRKCH0.65987131
93MAP2K10.65459341
94CHEK20.65133388
95STK30.63405848
96EIF2AK20.61748011
97RPS6KB10.61654920
98CAMK2A0.60162442
99PRKCE0.59640504
100STK240.59565978
101PRKG20.59114177
102CDC70.58562461
103NEK20.56539410
104STK38L0.56070475
105KSR20.55681988
106CAMK2G0.54824352
107PAK60.54459655
108ADRBK10.53859835
109UHMK10.53724070
110DYRK30.52385353
111PIK3CA0.51738521
112PDK40.51180235
113PDK30.51180235
114MAP3K10.50741318
115NME10.49546387
116PBK0.49025641
117PRKACA0.48256856
118PTK2B0.47947760
119TXK0.46003289
120PNCK0.45743127
121CDK80.44643321
122EPHB20.44327970
123CDK140.43716987
124CDK180.42934315
125ATR0.41883966
126NTRK20.41228515
127CSNK1D0.41144880
128ATM0.40491313
129NEK60.40301702
130GRK70.40086047
131ADRBK20.39693991
132ROCK10.39145375
133BMPR20.39127412
134NEK10.39036893
135RPS6KA50.38126733
136CSNK1G20.37887443
137PRKCQ0.37739108
138GRK10.36669321
139CSNK1A10.36267291
140STK380.35773406
141EIF2AK10.34669820
142CSNK2A10.34195692
143TEC0.34001771
144TRPM70.33943713
145CDK190.33675891
146FRK0.33253724
147FLT30.32122388
148MAPK100.31839472
149ROCK20.31363727
150AURKA0.30159299
151CSNK1G30.30052487
152PRKCB0.28216388
153PRKACG0.27936239
154MAP3K110.27365299
155FGFR30.27354180
156MYLK0.26233784
157CAMK2B0.26224591
158PDK20.25363608
159PIM20.24699553

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.86100439
2Olfactory transduction_Homo sapiens_hsa047403.35196601
3Nicotine addiction_Homo sapiens_hsa050332.98259944
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.86072046
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.49671285
6RNA polymerase_Homo sapiens_hsa030202.49043606
7* Taste transduction_Homo sapiens_hsa047422.43217435
8Protein export_Homo sapiens_hsa030602.42685899
9Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.39717272
10Parkinsons disease_Homo sapiens_hsa050122.29592091
11Oxidative phosphorylation_Homo sapiens_hsa001902.29077616
12Butanoate metabolism_Homo sapiens_hsa006502.19330235
13Homologous recombination_Homo sapiens_hsa034402.07212420
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06890192
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.05363683
16GABAergic synapse_Homo sapiens_hsa047272.04322538
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99851857
18Dopaminergic synapse_Homo sapiens_hsa047281.99300161
19Morphine addiction_Homo sapiens_hsa050321.97480251
20Basal transcription factors_Homo sapiens_hsa030221.96794245
21Circadian entrainment_Homo sapiens_hsa047131.95112791
22Selenocompound metabolism_Homo sapiens_hsa004501.91967914
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.89802404
24Glutamatergic synapse_Homo sapiens_hsa047241.89428121
25Linoleic acid metabolism_Homo sapiens_hsa005911.88794094
26Phototransduction_Homo sapiens_hsa047441.87735717
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.86061694
28Fanconi anemia pathway_Homo sapiens_hsa034601.78121942
29Nitrogen metabolism_Homo sapiens_hsa009101.72586800
30Salivary secretion_Homo sapiens_hsa049701.71223797
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70449472
32Non-homologous end-joining_Homo sapiens_hsa034501.68535488
33Long-term potentiation_Homo sapiens_hsa047201.67106434
34Cholinergic synapse_Homo sapiens_hsa047251.66883205
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66556593
36Insulin secretion_Homo sapiens_hsa049111.66553257
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63904785
38Amphetamine addiction_Homo sapiens_hsa050311.63859412
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.62632432
40Collecting duct acid secretion_Homo sapiens_hsa049661.61808536
41Ribosome_Homo sapiens_hsa030101.61135092
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60251864
43Alzheimers disease_Homo sapiens_hsa050101.59878066
44Cardiac muscle contraction_Homo sapiens_hsa042601.54363923
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.53254910
46Caffeine metabolism_Homo sapiens_hsa002321.51872282
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.51410355
48One carbon pool by folate_Homo sapiens_hsa006701.50487288
49Tryptophan metabolism_Homo sapiens_hsa003801.45545324
50* Serotonergic synapse_Homo sapiens_hsa047261.45092741
51RNA degradation_Homo sapiens_hsa030181.39631535
52Huntingtons disease_Homo sapiens_hsa050161.38236148
53* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37375645
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36307613
55Calcium signaling pathway_Homo sapiens_hsa040201.31736256
56Regulation of autophagy_Homo sapiens_hsa041401.29510679
57SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27112356
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27020730
59Cocaine addiction_Homo sapiens_hsa050301.26171325
60Peroxisome_Homo sapiens_hsa041461.21960856
61Dorso-ventral axis formation_Homo sapiens_hsa043201.21500729
62Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20554208
63Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18799254
64Pyruvate metabolism_Homo sapiens_hsa006201.16211238
65Mismatch repair_Homo sapiens_hsa034301.15798926
66Pyrimidine metabolism_Homo sapiens_hsa002401.15527738
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12624390
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11033274
69Vitamin digestion and absorption_Homo sapiens_hsa049771.10975894
70beta-Alanine metabolism_Homo sapiens_hsa004101.10538008
71Gastric acid secretion_Homo sapiens_hsa049711.10462692
72Sulfur relay system_Homo sapiens_hsa041221.07751079
73Renin secretion_Homo sapiens_hsa049241.07480907
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06478595
75Chemical carcinogenesis_Homo sapiens_hsa052041.05792406
76Cyanoamino acid metabolism_Homo sapiens_hsa004601.05592624
77Base excision repair_Homo sapiens_hsa034101.05569216
78GnRH signaling pathway_Homo sapiens_hsa049121.04708313
79Fatty acid elongation_Homo sapiens_hsa000621.03835024
80Retinol metabolism_Homo sapiens_hsa008301.03822038
81Gap junction_Homo sapiens_hsa045401.01047448
82Long-term depression_Homo sapiens_hsa047301.00456413
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00445335
84RNA transport_Homo sapiens_hsa030130.98879708
85Oocyte meiosis_Homo sapiens_hsa041140.98306225
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.94782669
87Nucleotide excision repair_Homo sapiens_hsa034200.94522168
88Purine metabolism_Homo sapiens_hsa002300.94468047
89Vibrio cholerae infection_Homo sapiens_hsa051100.93512024
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91639571
91Fat digestion and absorption_Homo sapiens_hsa049750.90548234
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90526816
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90462897
94ErbB signaling pathway_Homo sapiens_hsa040120.89128565
95Oxytocin signaling pathway_Homo sapiens_hsa049210.88592248
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88464363
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88082562
98Melanoma_Homo sapiens_hsa052180.87506272
99Melanogenesis_Homo sapiens_hsa049160.87215139
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.86622475
101Metabolic pathways_Homo sapiens_hsa011000.85638717
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84668705
103Axon guidance_Homo sapiens_hsa043600.84340089
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.78979553
105Histidine metabolism_Homo sapiens_hsa003400.77402571
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76731094
107Spliceosome_Homo sapiens_hsa030400.76343890
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73728299
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73717238
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73458615
111Thyroid cancer_Homo sapiens_hsa052160.73438966
112Arachidonic acid metabolism_Homo sapiens_hsa005900.72441854
113* cAMP signaling pathway_Homo sapiens_hsa040240.71781813
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70554410
115Insulin signaling pathway_Homo sapiens_hsa049100.70113534
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.67715319
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66978753
118Folate biosynthesis_Homo sapiens_hsa007900.65917365
119Sulfur metabolism_Homo sapiens_hsa009200.64783267
120Arginine and proline metabolism_Homo sapiens_hsa003300.63927024
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63207942
122Glucagon signaling pathway_Homo sapiens_hsa049220.61349509
123Glycerolipid metabolism_Homo sapiens_hsa005610.60603208
124DNA replication_Homo sapiens_hsa030300.60561533
125Glioma_Homo sapiens_hsa052140.59363583
126Thyroid hormone synthesis_Homo sapiens_hsa049180.58923823
127Phagosome_Homo sapiens_hsa041450.58461663
128Bile secretion_Homo sapiens_hsa049760.56452383
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56227969
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55845113
131MAPK signaling pathway_Homo sapiens_hsa040100.54659953
132Glutathione metabolism_Homo sapiens_hsa004800.54447430
133Ras signaling pathway_Homo sapiens_hsa040140.51770186
134Basal cell carcinoma_Homo sapiens_hsa052170.51497212
135Fatty acid degradation_Homo sapiens_hsa000710.51284190
136Endometrial cancer_Homo sapiens_hsa052130.48782537
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47012515
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.46430125
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44630475
140Pancreatic secretion_Homo sapiens_hsa049720.44387489
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44103153
142Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43666798
143Hedgehog signaling pathway_Homo sapiens_hsa043400.42945262
144Inositol phosphate metabolism_Homo sapiens_hsa005620.42675143
145Drug metabolism - other enzymes_Homo sapiens_hsa009830.42269942
146Circadian rhythm_Homo sapiens_hsa047100.40840262
147Rap1 signaling pathway_Homo sapiens_hsa040150.39554349
148Salmonella infection_Homo sapiens_hsa051320.37661710
149Ether lipid metabolism_Homo sapiens_hsa005650.36651130
150Vitamin B6 metabolism_Homo sapiens_hsa007500.35998854
151Steroid biosynthesis_Homo sapiens_hsa001000.34988513
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34221136
153Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32968376
154Phospholipase D signaling pathway_Homo sapiens_hsa040720.32875200
155Fatty acid metabolism_Homo sapiens_hsa012120.32440870
156Ovarian steroidogenesis_Homo sapiens_hsa049130.29225134
157Estrogen signaling pathway_Homo sapiens_hsa049150.28178114
158Prolactin signaling pathway_Homo sapiens_hsa049170.27720749
159ABC transporters_Homo sapiens_hsa020100.27355930
160Endocytosis_Homo sapiens_hsa041440.27090748
161Propanoate metabolism_Homo sapiens_hsa006400.25958688
162Proteasome_Homo sapiens_hsa030500.23076714
163Sphingolipid signaling pathway_Homo sapiens_hsa040710.21710678
164Rheumatoid arthritis_Homo sapiens_hsa053230.19523587

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