HTR1DP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of action potential (GO:0045760)9.40048813
2positive regulation of digestive system process (GO:0060456)8.17596941
3negative regulation of heart rate (GO:0010459)7.65765188
4positive regulation of steroid hormone secretion (GO:2000833)7.20157590
5positive regulation of synaptic transmission, GABAergic (GO:0032230)7.19830985
6regulation of glucocorticoid secretion (GO:2000849)6.76394217
7regulation of action potential (GO:0098900)5.56221806
8regulation of corticosteroid hormone secretion (GO:2000846)5.49961541
9microtubule nucleation (GO:0007020)5.00746256
10replication fork processing (GO:0031297)4.66519879
11positive regulation of renal sodium excretion (GO:0035815)4.51633963
12regulation of steroid hormone secretion (GO:2000831)4.12252884
13positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.04121330
14positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.85516166
15regulation of digestive system process (GO:0044058)3.74965200
16maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.63434222
17signal peptide processing (GO:0006465)3.59296250
18positive regulation of vesicle fusion (GO:0031340)3.57325543
19negative regulation of heart contraction (GO:0045822)3.54418377
20long-term memory (GO:0007616)3.52319904
21microtubule anchoring (GO:0034453)3.42285136
22growth hormone secretion (GO:0030252)3.41568990
23mesenchymal-epithelial cell signaling (GO:0060638)3.40226564
24presynaptic membrane assembly (GO:0097105)3.39930194
25regulation of relaxation of muscle (GO:1901077)3.38892582
26regulation of cardiac muscle cell contraction (GO:0086004)3.20918776
27regulation of Rac protein signal transduction (GO:0035020)3.18474661
28fatty acid elongation (GO:0030497)3.15120339
29regulation of protein glycosylation (GO:0060049)3.13497656
30response to pheromone (GO:0019236)3.13008661
31microtubule severing (GO:0051013)3.12248667
32RNA destabilization (GO:0050779)3.12015248
33establishment of protein localization to Golgi (GO:0072600)3.09858645
34photoreceptor cell maintenance (GO:0045494)3.07816259
35snRNA transcription (GO:0009301)3.07541777
36regulation of MHC class II biosynthetic process (GO:0045346)2.99123684
37regulation of synaptic transmission, GABAergic (GO:0032228)2.99058333
38protein K6-linked ubiquitination (GO:0085020)2.97760840
39regulation of renal sodium excretion (GO:0035813)2.94055742
40DNA strand renaturation (GO:0000733)2.93928568
41L-glutamate transport (GO:0015813)2.93079502
42regulation of inositol phosphate biosynthetic process (GO:0010919)2.92729540
43regulation of chemokine biosynthetic process (GO:0045073)2.90969982
44negative regulation of blood circulation (GO:1903523)2.87115023
45positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.86588502
46detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.84961246
47retinal ganglion cell axon guidance (GO:0031290)2.83864617
48retinal rod cell development (GO:0046548)2.83013052
49positive regulation of guanylate cyclase activity (GO:0031284)2.81976572
50cornea development in camera-type eye (GO:0061303)2.77680027
51cellular response to sterol (GO:0036315)2.77649405
52protein targeting to Golgi (GO:0000042)2.73448573
53regulation of chromatin silencing (GO:0031935)2.71603611
54retrograde transport, vesicle recycling within Golgi (GO:0000301)2.70218131
55cellular response to zinc ion (GO:0071294)2.69963251
56protein localization to cilium (GO:0061512)2.69830225
57regulation of excretion (GO:0044062)2.69819578
58determination of adult lifespan (GO:0008340)2.68947757
59neutrophil mediated immunity (GO:0002446)2.68906431
60positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.68391810
61negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.68192350
62acrosome assembly (GO:0001675)2.68098190
63protein targeting to vacuole (GO:0006623)2.67618018
64protein targeting to lysosome (GO:0006622)2.67618018
65establishment of protein localization to vacuole (GO:0072666)2.67618018
66glucosamine-containing compound catabolic process (GO:1901072)2.65276472
67zinc ion transport (GO:0006829)2.63538981
68acidic amino acid transport (GO:0015800)2.62875435
69retinal cone cell development (GO:0046549)2.61840685
70DNA replication-dependent nucleosome organization (GO:0034723)2.61415975
71DNA replication-dependent nucleosome assembly (GO:0006335)2.61415975
72C4-dicarboxylate transport (GO:0015740)2.60858983
73presynaptic membrane organization (GO:0097090)2.60388135
74response to isoquinoline alkaloid (GO:0014072)2.59765018
75negative regulation of neurotransmitter transport (GO:0051589)2.55095424
76response to morphine (GO:0043278)2.53260858
77regulation of integrin-mediated signaling pathway (GO:2001044)2.53196105
78sequestering of metal ion (GO:0051238)2.53132195
79negative regulation of translation, ncRNA-mediated (GO:0040033)2.50930833
80regulation of translation, ncRNA-mediated (GO:0045974)2.50930833
81negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.50930833
82postsynaptic membrane organization (GO:0001941)2.49954042
83positive regulation of growth hormone secretion (GO:0060124)2.49333026
84cellular response to cholesterol (GO:0071397)2.49192073
85regulation of cilium movement (GO:0003352)2.49074718
86nonmotile primary cilium assembly (GO:0035058)2.47408904
87regulation of guanylate cyclase activity (GO:0031282)2.44271646
88DNA double-strand break processing (GO:0000729)2.43152537
89zinc ion transmembrane transport (GO:0071577)2.42568547
90photoreceptor cell development (GO:0042461)2.39950217
91exocrine pancreas development (GO:0031017)2.39499455
92cellular response to ATP (GO:0071318)2.38374786
93proline transport (GO:0015824)2.38306162
94positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.37917582
95positive regulation of lipid transport (GO:0032370)2.37243281
96inner ear receptor stereocilium organization (GO:0060122)2.37092608
97regulation of neurotransmitter uptake (GO:0051580)2.36993021
98regulation of actin filament-based movement (GO:1903115)2.36910502
99water-soluble vitamin biosynthetic process (GO:0042364)2.36762455
100tachykinin receptor signaling pathway (GO:0007217)10.4665481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD_19615063_ChIP-ChIP_OVARY_Human3.43280147
2GBX2_23144817_ChIP-Seq_PC3_Human3.38537087
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.16204077
4POU3F2_20337985_ChIP-ChIP_501MEL_Human3.15600259
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.03746115
6IGF1R_20145208_ChIP-Seq_DFB_Human2.82271031
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.78942830
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.75548039
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57662191
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.56445524
11AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.54148820
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53177560
13FUS_26573619_Chip-Seq_HEK293_Human2.50691196
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.40179906
15PIAS1_25552417_ChIP-Seq_VCAP_Human2.22985359
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21051725
17ZNF274_21170338_ChIP-Seq_K562_Hela2.19491999
18P300_19829295_ChIP-Seq_ESCs_Human2.11515739
19SMAD4_21799915_ChIP-Seq_A2780_Human2.07611868
20STAT3_23295773_ChIP-Seq_U87_Human2.01746223
21VDR_22108803_ChIP-Seq_LS180_Human2.00934637
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96797779
23TAF15_26573619_Chip-Seq_HEK293_Human1.93131543
24NR3C1_21868756_ChIP-Seq_MCF10A_Human1.91532742
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91515070
26EWS_26573619_Chip-Seq_HEK293_Human1.88086160
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.86472842
28ER_23166858_ChIP-Seq_MCF-7_Human1.79113080
29TCF4_23295773_ChIP-Seq_U87_Human1.76658448
30KLF5_20875108_ChIP-Seq_MESCs_Mouse1.70233700
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67777344
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65255954
33CBP_20019798_ChIP-Seq_JUKART_Human1.64914422
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64914422
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62620755
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62544431
37BCAT_22108803_ChIP-Seq_LS180_Human1.56460807
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56221335
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.53944291
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53942206
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51800452
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.47315660
43AHR_22903824_ChIP-Seq_MCF-7_Human1.43013896
44FLI1_21867929_ChIP-Seq_TH2_Mouse1.40143575
45RUNX2_22187159_ChIP-Seq_PCA_Human1.39796986
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.39561904
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38967709
48ELK1_19687146_ChIP-ChIP_HELA_Human1.38631736
49TCF4_22108803_ChIP-Seq_LS180_Human1.38198283
50FOXM1_26456572_ChIP-Seq_MCF-7_Human1.37868057
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37038330
52AR_25329375_ChIP-Seq_VCAP_Human1.35450421
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35095852
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34822124
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34751456
56TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.33841636
57TP53_16413492_ChIP-PET_HCT116_Human1.32936428
58CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.31735244
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.30916255
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29813962
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.27330578
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26632623
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25474915
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25474915
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25291394
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25024896
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22984589
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22984220
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.20076143
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19614950
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19419676
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15143546
73SMAD4_21741376_ChIP-Seq_EPCs_Human1.14196915
74FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12992057
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12510621
76OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12390706
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11975306
78SMAD3_21741376_ChIP-Seq_HESCs_Human1.10860251
79PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.10711722
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.09491380
81RXR_22108803_ChIP-Seq_LS180_Human1.09185112
82AR_20517297_ChIP-Seq_VCAP_Human1.07599768
83SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07297062
84HTT_18923047_ChIP-ChIP_STHdh_Human1.05482255
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05176093
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04981834
87SALL4_22934838_ChIP-ChIP_CD34+_Human1.03077515
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01863141
89SOX2_19829295_ChIP-Seq_ESCs_Human1.01720111
90NANOG_19829295_ChIP-Seq_ESCs_Human1.01720111
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.01662339
92KDM2B_26808549_Chip-Seq_REH_Human1.01136435
93ETV1_20927104_ChIP-Seq_GIST48_Human1.00972873
94AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00228597
95E2F1_18555785_Chip-Seq_ESCs_Mouse0.99431400
96TBL1_22424771_ChIP-Seq_293T_Human0.97637854
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.97485092
98SOX9_26525672_Chip-Seq_HEART_Mouse0.97458185
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97256402
100CJUN_26792858_Chip-Seq_BT549_Human0.95876787

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder7.03510776
2MP0000569_abnormal_digit_pigmentation5.39880163
3MP0008057_abnormal_DNA_replication4.09095269
4MP0003950_abnormal_plasma_membrane3.14065676
5MP0009780_abnormal_chondrocyte_physiolo3.08631152
6MP0008877_abnormal_DNA_methylation3.01450276
7MP0003787_abnormal_imprinting2.70804364
8MP0003011_delayed_dark_adaptation2.66528144
9MP0001968_abnormal_touch/_nociception2.33037456
10MP0000427_abnormal_hair_cycle2.32263674
11MP0001486_abnormal_startle_reflex2.22872311
12MP0001501_abnormal_sleep_pattern2.22129172
13MP0000383_abnormal_hair_follicle2.18430641
14MP0006072_abnormal_retinal_apoptosis2.13251366
15MP0005174_abnormal_tail_pigmentation2.08304816
16MP0001984_abnormal_olfaction1.99579577
17MP0005253_abnormal_eye_physiology1.98752328
18MP0003195_calcinosis1.95854016
19MP0002254_reproductive_system_inflammat1.91063032
20MP0001756_abnormal_urination1.90631943
21MP0005551_abnormal_eye_electrophysiolog1.86317546
22MP0009697_abnormal_copulation1.79854411
23MP0005646_abnormal_pituitary_gland1.79281965
24MP0002102_abnormal_ear_morphology1.77592537
25MP0001661_extended_life_span1.72871375
26MP0002837_dystrophic_cardiac_calcinosis1.72423998
27MP0004147_increased_porphyrin_level1.71381286
28MP0010678_abnormal_skin_adnexa1.71369540
29MP0000015_abnormal_ear_pigmentation1.69163464
30MP0001986_abnormal_taste_sensitivity1.60260248
31MP0002736_abnormal_nociception_after1.53453536
32MP0002138_abnormal_hepatobiliary_system1.52727436
33MP0005647_abnormal_sex_gland1.51632747
34MP0003879_abnormal_hair_cell1.43447931
35MP0004215_abnormal_myocardial_fiber1.40473948
36MP0001485_abnormal_pinna_reflex1.40276068
37MP0003283_abnormal_digestive_organ1.34175124
38MP0005075_abnormal_melanosome_morpholog1.30048359
39MP0000538_abnormal_urinary_bladder1.29071948
40MP0003183_abnormal_peptide_metabolism1.28535968
41MP0004742_abnormal_vestibular_system1.22624586
42MP0003252_abnormal_bile_duct1.20348154
43MP0002751_abnormal_autonomic_nervous1.16062941
44MP0000013_abnormal_adipose_tissue1.14742464
45MP0001879_abnormal_lymphatic_vessel1.10028707
46MP0000516_abnormal_urinary_system1.05253179
47MP0005367_renal/urinary_system_phenotyp1.05253179
48MP0005266_abnormal_metabolism1.00607234
49MP0003943_abnormal_hepatobiliary_system0.98871862
50MP0002163_abnormal_gland_morphology0.98669498
51MP0000647_abnormal_sebaceous_gland0.98561059
52MP0001970_abnormal_pain_threshold0.98286501
53MP0000003_abnormal_adipose_tissue0.96964041
54MP0003121_genomic_imprinting0.95463297
55MP0009046_muscle_twitch0.94196840
56MP0005171_absent_coat_pigmentation0.92778729
57MP0005636_abnormal_mineral_homeostasis0.92561436
58MP0002272_abnormal_nervous_system0.88896391
59MP0004885_abnormal_endolymph0.88387702
60MP0009278_abnormal_bone_marrow0.87834926
61MP0002064_seizures0.87631813
62MP0003880_abnormal_central_pattern0.87317672
63MP0002295_abnormal_pulmonary_circulatio0.85880143
64MP0005391_vision/eye_phenotype0.85781878
65MP0001764_abnormal_homeostasis0.85185245
66MP0002229_neurodegeneration0.82996728
67MP0001963_abnormal_hearing_physiology0.82904589
68MP0009745_abnormal_behavioral_response0.82875627
69MP0003656_abnormal_erythrocyte_physiolo0.80732113
70MP0001502_abnormal_circadian_rhythm0.79941848
71MP0000631_abnormal_neuroendocrine_gland0.77379918
72MP0005410_abnormal_fertilization0.76850993
73MP0008058_abnormal_DNA_repair0.76380337
74MP0002938_white_spotting0.74711062
75MP0005220_abnormal_exocrine_pancreas0.74654498
76MP0002734_abnormal_mechanical_nocicepti0.73714852
77MP0003045_fibrosis0.72238350
78MP0002095_abnormal_skin_pigmentation0.72057655
79MP0002067_abnormal_sensory_capabilities0.72026980
80MP0004133_heterotaxia0.71009201
81MP0008775_abnormal_heart_ventricle0.69544027
82MP0003172_abnormal_lysosome_physiology0.68590298
83MP0010094_abnormal_chromosome_stability0.67882833
84MP0003937_abnormal_limbs/digits/tail_de0.67047710
85MP0010329_abnormal_lipoprotein_level0.66107536
86MP0005376_homeostasis/metabolism_phenot0.65115925
87MP0004924_abnormal_behavior0.64628057
88MP0005386_behavior/neurological_phenoty0.64628057
89MP0002184_abnormal_innervation0.63186746
90MP0005275_abnormal_skin_tensile0.62933931
91MP0005379_endocrine/exocrine_gland_phen0.62823498
92MP0000358_abnormal_cell_content/0.62655420
93MP0002572_abnormal_emotion/affect_behav0.60599747
94MP0002160_abnormal_reproductive_system0.60197039
95MP0002090_abnormal_vision0.59917820
96MP0003698_abnormal_male_reproductive0.56249956
97MP0001324_abnormal_eye_pigmentation0.53900206
98MP0001929_abnormal_gametogenesis0.52761883
99MP0008007_abnormal_cellular_replicative0.52670081
100MP0008260_abnormal_autophagy0.52466464

Predicted human phenotypes

RankGene SetZ-score
1Amyotrophic lateral sclerosis (HP:0007354)5.20617728
2Abnormality of the lower motor neuron (HP:0002366)4.78565104
3Fair hair (HP:0002286)4.49936563
4Hip dysplasia (HP:0001385)3.83774045
5Thoracolumbar scoliosis (HP:0002944)3.83171600
6Nephronophthisis (HP:0000090)3.64423354
7Papillary thyroid carcinoma (HP:0002895)3.63581711
8Calf muscle hypertrophy (HP:0008981)3.45228882
9Generalized hypopigmentation of hair (HP:0011358)3.27395228
10Clumsiness (HP:0002312)3.00387509
11Tented upper lip vermilion (HP:0010804)2.99639621
12Muscle hypertrophy of the lower extremities (HP:0008968)2.97967116
13Rhabdomyosarcoma (HP:0002859)2.95256407
14Abnormality of the renal medulla (HP:0100957)2.94988538
15Follicular hyperkeratosis (HP:0007502)2.91667327
16Hemiparesis (HP:0001269)2.89874257
17Atrophy/Degeneration involving motor neurons (HP:0007373)2.85027168
18Tetraparesis (HP:0002273)2.80934877
19Increased density of long bones (HP:0006392)2.80639331
20Hypophosphatemic rickets (HP:0004912)2.75419025
21Abnormality of lateral ventricle (HP:0030047)2.75286866
22Dyskinesia (HP:0100660)2.74268916
23Medial flaring of the eyebrow (HP:0010747)2.73683797
24Broad-based gait (HP:0002136)2.63711798
25Albinism (HP:0001022)2.59972999
26Rectal fistula (HP:0100590)2.58392818
27Rectovaginal fistula (HP:0000143)2.58392818
28Neoplasm of striated muscle (HP:0009728)2.55428011
29Action tremor (HP:0002345)2.54682183
30Hyperventilation (HP:0002883)2.49103705
31Abnormality of midbrain morphology (HP:0002418)2.46619531
32Molar tooth sign on MRI (HP:0002419)2.46619531
33Prominent nose (HP:0000448)2.41567052
34Periodontitis (HP:0000704)2.41552855
35Intestinal fistula (HP:0100819)2.37882891
36Aplasia/hypoplasia of the uterus (HP:0008684)2.35264473
37Gaze-evoked nystagmus (HP:0000640)2.33652224
38Protruding tongue (HP:0010808)2.32470648
39Shawl scrotum (HP:0000049)2.30827504
40Large for gestational age (HP:0001520)2.30692544
41Thyroid carcinoma (HP:0002890)2.29466650
42Abnormality of aspartate family amino acid metabolism (HP:0010899)2.28201907
43Drooling (HP:0002307)2.26873378
44Genital tract atresia (HP:0001827)2.26694094
45Glioma (HP:0009733)2.19912167
46Abnormality of vitamin B metabolism (HP:0004340)2.18081338
47Congenital primary aphakia (HP:0007707)2.13813507
48Difficulty running (HP:0009046)2.11548206
49Hypokinesia (HP:0002375)2.10785705
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.10647858
51Gait imbalance (HP:0002141)2.09415757
52Cerebellar dysplasia (HP:0007033)2.08475333
53Eosinophilia (HP:0001880)2.06710648
54Pancreatic fibrosis (HP:0100732)2.06595610
55Excessive salivation (HP:0003781)2.05988217
56Abnormality of serum amino acid levels (HP:0003112)2.04270299
57Astigmatism (HP:0000483)2.02767965
58Pancreatic cysts (HP:0001737)2.01856595
59Vaginal atresia (HP:0000148)1.99887933
60Inappropriate behavior (HP:0000719)1.99653730
61Abnormality of the vitamin B12 metabolism (HP:0004341)1.99336000
62Poor coordination (HP:0002370)1.98086541
63Type II lissencephaly (HP:0007260)1.98007425
64Carpal bone hypoplasia (HP:0001498)1.96116757
65Bifid tongue (HP:0010297)1.95637067
66Hypoplastic labia majora (HP:0000059)1.95274769
67Thrombocytosis (HP:0001894)1.94657214
68Abnormality of methionine metabolism (HP:0010901)1.91448827
69Renal hypoplasia (HP:0000089)1.91192995
70Anal atresia (HP:0002023)1.90201830
71Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89034763
72Chromsome breakage (HP:0040012)1.88008901
73Exotropia (HP:0000577)1.87889042
74Diminished motivation (HP:0000745)1.86802230
75Disproportionate short-trunk short stature (HP:0003521)1.84096954
76Vaginal fistula (HP:0004320)1.83562782
77Methylmalonic acidemia (HP:0002912)1.83474784
78Apathy (HP:0000741)1.81548586
79Azoospermia (HP:0000027)1.80844327
80Abnormality of the astrocytes (HP:0100707)1.80258999
81Astrocytoma (HP:0009592)1.80258999
82Ulnar claw (HP:0001178)1.80218751
83Microtia (HP:0008551)1.78805722
84Postural tremor (HP:0002174)1.76224769
85Gonadotropin excess (HP:0000837)1.76085123
86Attenuation of retinal blood vessels (HP:0007843)1.75466101
87Abnormality of the labia majora (HP:0012881)1.75358285
88Abnormality of alanine metabolism (HP:0010916)1.74839260
89Hyperalaninemia (HP:0003348)1.74839260
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74839260
91IgM deficiency (HP:0002850)1.74137060
92Metaphyseal dysplasia (HP:0100255)1.73810269
93Delusions (HP:0000746)1.73188721
94Abnormality of the ischium (HP:0003174)1.72541365
95Abnormality of chromosome stability (HP:0003220)1.72438105
96Hypothermia (HP:0002045)1.72426109
97Type I transferrin isoform profile (HP:0003642)1.72038358
98Nephrogenic diabetes insipidus (HP:0009806)1.71971524
99Macroorchidism (HP:0000053)1.70417268
100Absent speech (HP:0001344)1.69967724

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK27.62000364
2FRK4.46283486
3PRKD34.03979097
4BMPR1B3.37712265
5MAP3K42.39719757
6NLK2.39335239
7PRKD22.32224083
8BCKDK2.03969105
9BRSK21.94858196
10MAPK131.91400849
11NUAK11.87880544
12PRKCH1.80232239
13ACVR1B1.79763571
14TRIM281.78085164
15ZAK1.72319938
16WNK31.67628926
17CCNB11.63561603
18TGFBR11.60005056
19MAP4K21.55859971
20ERBB31.43773313
21DYRK31.32285352
22PKN21.29626902
23CASK1.28117147
24NEK61.24788917
25PTK2B1.21756055
26SGK21.19074461
27PRKCE1.18379980
28FLT31.11554013
29TRPM71.11185054
30STK241.11105269
31SRPK11.11075394
32MAP3K21.09233517
33AKT31.09026839
34NTRK21.08112058
35PLK21.02427871
36BMPR21.01261035
37MARK31.00569536
38TNK20.97036107
39NTRK30.91913834
40LATS10.90459281
41DYRK1A0.89755293
42MKNK20.89295653
43TAOK30.89008499
44PBK0.86913888
45INSRR0.84096504
46MARK10.82982866
47FER0.79035416
48GSK3A0.77392747
49MST40.73882786
50MAP2K70.73670483
51PLK40.70592205
52OBSCN0.69655128
53ADRBK20.69341716
54SGK30.68991336
55MAPKAPK30.66434220
56FGFR10.66107486
57PAK30.64169598
58TGFBR20.60837762
59CDK80.59225553
60ATM0.57520452
61CAMK1D0.56192365
62GRK10.55825984
63TNIK0.55546769
64IRAK10.54940208
65PLK30.54423284
66EPHA30.52373583
67BRSK10.52230471
68RPS6KA40.51427412
69MAPK120.50028968
70DAPK20.49346584
71MAPK70.48957624
72ATR0.48908463
73PIK3CG0.48819514
74PKN10.44539787
75MAP3K70.44225970
76PRKCQ0.43562096
77RPS6KB20.40514005
78CAMK40.39865802
79SGK4940.39242141
80SGK2230.39242141
81CAMK1G0.37429720
82ADRBK10.36889696
83CSNK1G10.34622917
84CAMK10.34192083
85MET0.33184534
86FGFR20.31925318
87TYK20.31919056
88PIK3CA0.31292397
89TEC0.31225994
90PRKACA0.30164641
91STK390.28611360
92STK38L0.28603333
93ABL10.25977915
94PRKD10.25176567
95CDK90.24501756
96STK380.23987007
97MKNK10.23095279
98KIT0.23001760
99ROCK10.22088663
100EIF2AK30.21538955

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.81616744
2Nicotine addiction_Homo sapiens_hsa050332.75291034
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.62811102
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.50940729
5Nitrogen metabolism_Homo sapiens_hsa009102.46170529
6Homologous recombination_Homo sapiens_hsa034402.44754429
7Butanoate metabolism_Homo sapiens_hsa006502.36370443
8Lysine degradation_Homo sapiens_hsa003102.13594138
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12028108
10Fanconi anemia pathway_Homo sapiens_hsa034602.09861582
11Olfactory transduction_Homo sapiens_hsa047402.09266904
12Fatty acid elongation_Homo sapiens_hsa000622.09143077
13Propanoate metabolism_Homo sapiens_hsa006402.07104016
14Dorso-ventral axis formation_Homo sapiens_hsa043202.05791878
15Fatty acid metabolism_Homo sapiens_hsa012122.00182934
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.86830916
17Renin-angiotensin system_Homo sapiens_hsa046141.74771239
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.68482010
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67931558
20Taste transduction_Homo sapiens_hsa047421.67557024
21Selenocompound metabolism_Homo sapiens_hsa004501.65245404
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58336470
23Non-homologous end-joining_Homo sapiens_hsa034501.56511000
24Sulfur metabolism_Homo sapiens_hsa009201.55242607
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50192782
26Protein export_Homo sapiens_hsa030601.46014554
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.43493119
28Fatty acid degradation_Homo sapiens_hsa000711.43051770
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41693085
30Tryptophan metabolism_Homo sapiens_hsa003801.38471975
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34128182
32Circadian rhythm_Homo sapiens_hsa047101.32281884
33Regulation of autophagy_Homo sapiens_hsa041401.28987615
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.27621753
35Fatty acid biosynthesis_Homo sapiens_hsa000611.21123380
36RNA polymerase_Homo sapiens_hsa030201.20348362
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18341318
38Sphingolipid metabolism_Homo sapiens_hsa006001.13458521
39Caffeine metabolism_Homo sapiens_hsa002321.13380422
40Basal transcription factors_Homo sapiens_hsa030221.12835921
41One carbon pool by folate_Homo sapiens_hsa006701.12534977
42Nucleotide excision repair_Homo sapiens_hsa034201.11481290
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10911126
44Mineral absorption_Homo sapiens_hsa049781.09887113
45Hedgehog signaling pathway_Homo sapiens_hsa043401.09842992
46PPAR signaling pathway_Homo sapiens_hsa033201.06297431
47Ether lipid metabolism_Homo sapiens_hsa005650.99151940
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93586842
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93309980
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92727685
51ABC transporters_Homo sapiens_hsa020100.91174320
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89667362
53Insulin secretion_Homo sapiens_hsa049110.88420806
54Bile secretion_Homo sapiens_hsa049760.88374093
55Chemical carcinogenesis_Homo sapiens_hsa052040.88105982
56Mismatch repair_Homo sapiens_hsa034300.87992134
57Glutamatergic synapse_Homo sapiens_hsa047240.85703279
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85604397
59Base excision repair_Homo sapiens_hsa034100.81647403
60Peroxisome_Homo sapiens_hsa041460.80714692
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77454827
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75460260
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.75034539
64RNA degradation_Homo sapiens_hsa030180.74308018
65beta-Alanine metabolism_Homo sapiens_hsa004100.72769702
66Phenylalanine metabolism_Homo sapiens_hsa003600.71216252
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.68859846
68Purine metabolism_Homo sapiens_hsa002300.67624785
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64905685
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63864303
71Linoleic acid metabolism_Homo sapiens_hsa005910.61734756
72Amphetamine addiction_Homo sapiens_hsa050310.59836227
73Histidine metabolism_Homo sapiens_hsa003400.56415059
74Morphine addiction_Homo sapiens_hsa050320.55482032
75Pyruvate metabolism_Homo sapiens_hsa006200.55338306
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53453546
77Proteasome_Homo sapiens_hsa030500.50915008
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50353578
79N-Glycan biosynthesis_Homo sapiens_hsa005100.50024905
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49688264
81Synaptic vesicle cycle_Homo sapiens_hsa047210.48674629
82Retinol metabolism_Homo sapiens_hsa008300.48078415
83Glucagon signaling pathway_Homo sapiens_hsa049220.45988096
84Complement and coagulation cascades_Homo sapiens_hsa046100.42221155
85Metabolic pathways_Homo sapiens_hsa011000.42045781
86Starch and sucrose metabolism_Homo sapiens_hsa005000.41362488
87Circadian entrainment_Homo sapiens_hsa047130.38962403
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37303972
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36963842
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35519600
91Glutathione metabolism_Homo sapiens_hsa004800.35215089
92Basal cell carcinoma_Homo sapiens_hsa052170.34558026
93Pancreatic secretion_Homo sapiens_hsa049720.33918354
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33619290
95Protein digestion and absorption_Homo sapiens_hsa049740.33366114
96Glycerolipid metabolism_Homo sapiens_hsa005610.33299164
97FoxO signaling pathway_Homo sapiens_hsa040680.33038364
98Tyrosine metabolism_Homo sapiens_hsa003500.32978035
99Serotonergic synapse_Homo sapiens_hsa047260.31498950
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31143919

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