HTR1E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.58151722
2synaptic vesicle docking involved in exocytosis (GO:0016081)6.36134856
3glutamate secretion (GO:0014047)6.25536589
4synaptic vesicle exocytosis (GO:0016079)6.21498392
5regulation of short-term neuronal synaptic plasticity (GO:0048172)6.16814513
6gamma-aminobutyric acid signaling pathway (GO:0007214)5.83652194
7regulation of synaptic vesicle exocytosis (GO:2000300)5.79968750
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.13688187
9sodium ion export (GO:0071436)5.09364035
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.08395135
11regulation of synaptic vesicle transport (GO:1902803)4.98401562
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.93868735
13neurotransmitter secretion (GO:0007269)4.73080064
14L-amino acid import (GO:0043092)4.72149840
15vocalization behavior (GO:0071625)4.68817275
16cellular potassium ion homeostasis (GO:0030007)4.66672224
17regulation of neuronal synaptic plasticity (GO:0048168)4.51750443
18exploration behavior (GO:0035640)4.48365873
19protein localization to synapse (GO:0035418)4.45007617
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.41384163
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.38728529
22neurotransmitter-gated ion channel clustering (GO:0072578)4.30824079
23sexual reproduction (GO:0019953)4.29307471
24locomotory exploration behavior (GO:0035641)4.27183313
25neuron cell-cell adhesion (GO:0007158)4.23121451
26regulation of vesicle fusion (GO:0031338)4.17244333
27neuronal action potential propagation (GO:0019227)4.11607608
28neurotransmitter transport (GO:0006836)4.10702866
29synaptic transmission, glutamatergic (GO:0035249)4.09760543
30amino acid import (GO:0043090)4.03576341
31sequestering of actin monomers (GO:0042989)4.01431505
32postsynaptic membrane organization (GO:0001941)4.01041153
33neuron-neuron synaptic transmission (GO:0007270)4.00529280
34regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.99024052
35positive regulation of synapse maturation (GO:0090129)3.98663784
36regulation of synapse structural plasticity (GO:0051823)3.98012396
37negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.97341761
38regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.95548651
39response to histamine (GO:0034776)3.95511504
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.89673386
41layer formation in cerebral cortex (GO:0021819)3.89400796
42glutamate receptor signaling pathway (GO:0007215)3.78832914
43negative regulation of dendrite morphogenesis (GO:0050774)3.76031960
44cell communication by electrical coupling (GO:0010644)3.75159702
45regulation of neurotransmitter levels (GO:0001505)3.74449041
46regulation of synaptic plasticity (GO:0048167)3.60203011
47behavioral response to cocaine (GO:0048148)3.58905160
48regulation of glutamate receptor signaling pathway (GO:1900449)3.58825162
49regulation of voltage-gated calcium channel activity (GO:1901385)3.58520952
50regulation of neurotransmitter secretion (GO:0046928)3.57032719
51positive regulation of membrane potential (GO:0045838)3.56984078
52positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.55625597
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.52339599
54long-term memory (GO:0007616)3.50511114
55mating behavior (GO:0007617)3.49751552
56neuronal ion channel clustering (GO:0045161)3.43689145
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.41004145
58cerebellar granule cell differentiation (GO:0021707)3.39607799
59regulation of neurotransmitter transport (GO:0051588)3.37756434
60neuromuscular synaptic transmission (GO:0007274)3.37360451
61transmission of nerve impulse (GO:0019226)3.35932734
62cerebellar Purkinje cell differentiation (GO:0021702)3.31474979
63auditory behavior (GO:0031223)3.28732740
64positive regulation of neurotransmitter transport (GO:0051590)3.28390787
65neuromuscular process controlling posture (GO:0050884)3.24344453
66synaptic vesicle endocytosis (GO:0048488)3.19043651
67adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.18137633
68neuromuscular process controlling balance (GO:0050885)3.17220967
69positive regulation of dendritic spine development (GO:0060999)3.15735151
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.15638903
71potassium ion homeostasis (GO:0055075)3.13634707
72cell communication involved in cardiac conduction (GO:0086065)3.11671758
73acidic amino acid transport (GO:0015800)3.11177632
74regulation of postsynaptic membrane potential (GO:0060078)3.09967011
75regulation of dendritic spine morphogenesis (GO:0061001)3.07311149
76* synaptic transmission (GO:0007268)3.04995353
77membrane depolarization during action potential (GO:0086010)3.04692886
78presynaptic membrane assembly (GO:0097105)3.04170680
79regulation of synapse maturation (GO:0090128)3.02088358
80neurotransmitter uptake (GO:0001504)3.02058651
81behavioral fear response (GO:0001662)3.01197472
82behavioral defense response (GO:0002209)3.01197472
83regulation of synaptic transmission (GO:0050804)3.00207333
84fear response (GO:0042596)2.95619986
85innervation (GO:0060384)2.93594765
86positive regulation of dendritic spine morphogenesis (GO:0061003)2.93206417
87membrane depolarization (GO:0051899)2.93184141
88response to amphetamine (GO:0001975)2.93044396
89synaptic vesicle transport (GO:0048489)2.92086278
90establishment of synaptic vesicle localization (GO:0097480)2.92086278
91neuron recognition (GO:0008038)2.90630193
92regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.90301181
93regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.90301181
94C4-dicarboxylate transport (GO:0015740)2.89415795
95long-term synaptic potentiation (GO:0060291)2.89204153
96activation of protein kinase A activity (GO:0034199)2.87789735
97L-glutamate transport (GO:0015813)2.87755477
98central nervous system myelination (GO:0022010)2.86594321
99axon ensheathment in central nervous system (GO:0032291)2.86594321
100cellular sodium ion homeostasis (GO:0006883)2.86211702

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.80941393
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.70134103
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.61341033
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.18743193
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02499979
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.00456087
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89074759
8REST_21632747_ChIP-Seq_MESCs_Mouse2.87256671
9GBX2_23144817_ChIP-Seq_PC3_Human2.75846729
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73038536
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69257932
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69257932
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.68637522
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62799133
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.60143015
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48083182
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47554564
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47401669
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42888743
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.42242239
21TAF15_26573619_Chip-Seq_HEK293_Human2.40205073
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40001518
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.39132159
24DROSHA_22980978_ChIP-Seq_HELA_Human2.23730681
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.21964960
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20709252
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.17061211
28NR3C1_23031785_ChIP-Seq_PC12_Mouse1.96878192
29RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.86871946
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82031233
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71630827
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70086936
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.68653875
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66425887
35RNF2_27304074_Chip-Seq_NSC_Mouse1.64680200
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56969938
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56787202
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56618165
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50316824
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.47861440
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46688460
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.45668526
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.37756562
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36212490
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34370828
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33809045
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.33730779
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.33157006
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.32304216
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28699787
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26962799
52RING1B_27294783_Chip-Seq_NPCs_Mouse1.25908637
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23457109
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16675870
55P300_19829295_ChIP-Seq_ESCs_Human1.15784558
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15128768
57YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13770717
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.13039295
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12088079
60* AR_19668381_ChIP-Seq_PC3_Human1.11418157
61SMAD3_21741376_ChIP-Seq_HESCs_Human1.11049573
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09722828
63TRIM28_21343339_ChIP-Seq_HEK293_Human1.09508813
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09121978
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08848332
66MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08102522
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07222658
68* SMAD4_21799915_ChIP-Seq_A2780_Human1.06917760
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04534654
70TET1_21490601_ChIP-Seq_MESCs_Mouse1.03394707
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.02513503
72GATA1_26923725_Chip-Seq_HPCs_Mouse1.00656983
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00044519
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99987355
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99259924
76CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96505919
77* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95919832
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94162425
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94162425
80TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94078527
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92504842
82ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89377009
83SMAD4_21741376_ChIP-Seq_HESCs_Human0.89038428
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87312106
85AHR_22903824_ChIP-Seq_MCF-7_Human0.87249199
86* JUN_21703547_ChIP-Seq_K562_Human0.86487730
87CTCF_27219007_Chip-Seq_Bcells_Human0.86380020
88ESR1_20079471_ChIP-ChIP_T-47D_Human0.84974931
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84532613
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83855461
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83785332
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82761482
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82320380
94KDM2B_26808549_Chip-Seq_K562_Human0.81450406
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81104276
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80403190
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79407100
98AR_21572438_ChIP-Seq_LNCaP_Human0.78664958
99POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78169622
100ISL1_27105846_Chip-Seq_CPCs_Mouse0.77832465

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.76215090
2MP0003880_abnormal_central_pattern4.89793646
3MP0004270_analgesia3.95900774
4MP0005423_abnormal_somatic_nervous3.53318483
5MP0003635_abnormal_synaptic_transmissio3.48449969
6MP0009745_abnormal_behavioral_response3.34055701
7MP0002064_seizures3.28412585
8MP0000566_synostosis3.11679640
9MP0002822_catalepsy2.86670277
10MP0001968_abnormal_touch/_nociception2.77511754
11MP0001486_abnormal_startle_reflex2.71553794
12MP0002734_abnormal_mechanical_nocicepti2.68188113
13MP0002736_abnormal_nociception_after2.65249538
14MP0002063_abnormal_learning/memory/cond2.64063902
15MP0009046_muscle_twitch2.60807917
16MP0002272_abnormal_nervous_system2.54959539
17MP0002572_abnormal_emotion/affect_behav2.35206702
18MP0005248_abnormal_Harderian_gland2.29394586
19MP0001529_abnormal_vocalization2.12342249
20MP0001346_abnormal_lacrimal_gland2.11326109
21MP0003122_maternal_imprinting2.04898378
22MP0003787_abnormal_imprinting1.85490077
23MP0008569_lethality_at_weaning1.80240715
24MP0005646_abnormal_pituitary_gland1.80145404
25MP0003329_amyloid_beta_deposits1.77437410
26MP0003123_paternal_imprinting1.76434540
27MP0003283_abnormal_digestive_organ1.74816123
28MP0000778_abnormal_nervous_system1.64520915
29MP0002735_abnormal_chemical_nociception1.62314812
30MP0002067_abnormal_sensory_capabilities1.59978001
31MP0002184_abnormal_innervation1.54490796
32MP0001440_abnormal_grooming_behavior1.53458097
33MP0003879_abnormal_hair_cell1.52020468
34MP0001501_abnormal_sleep_pattern1.49141495
35MP0006276_abnormal_autonomic_nervous1.47392408
36MP0001970_abnormal_pain_threshold1.45077616
37MP0000955_abnormal_spinal_cord1.42580220
38MP0005171_absent_coat_pigmentation1.38968034
39MP0002557_abnormal_social/conspecific_i1.38821057
40MP0001905_abnormal_dopamine_level1.38337056
41MP0002733_abnormal_thermal_nociception1.33434677
42MP0002066_abnormal_motor_capabilities/c1.30382485
43MP0002909_abnormal_adrenal_gland1.27743711
44MP0004811_abnormal_neuron_physiology1.27456000
45MP0002882_abnormal_neuron_morphology1.25710515
46MP0001177_atelectasis1.23848551
47MP0005386_behavior/neurological_phenoty1.21353481
48MP0004924_abnormal_behavior1.21353481
49MP0003633_abnormal_nervous_system1.19335617
50MP0001984_abnormal_olfaction1.19037396
51MP0000462_abnormal_digestive_system1.18932791
52MP0001188_hyperpigmentation1.17324242
53MP0009780_abnormal_chondrocyte_physiolo1.11449993
54MP0003121_genomic_imprinting1.06664282
55MP0001963_abnormal_hearing_physiology1.06661548
56MP0003631_nervous_system_phenotype1.05134115
57MP0004885_abnormal_endolymph1.04253526
58MP0003890_abnormal_embryonic-extraembry1.02347122
59MP0003119_abnormal_digestive_system1.02234163
60MP0002152_abnormal_brain_morphology1.02159574
61MP0001502_abnormal_circadian_rhythm1.01825738
62MP0000579_abnormal_nail_morphology0.96796838
63MP0003938_abnormal_ear_development0.95238336
64MP0004147_increased_porphyrin_level0.93178251
65MP0002229_neurodegeneration0.92213489
66MP0002751_abnormal_autonomic_nervous0.86783679
67MP0002102_abnormal_ear_morphology0.86575613
68MP0005394_taste/olfaction_phenotype0.85636581
69MP0005499_abnormal_olfactory_system0.85636581
70MP0008872_abnormal_physiological_respon0.84197106
71MP0000639_abnormal_adrenal_gland0.77889773
72MP0008877_abnormal_DNA_methylation0.77777868
73MP0010386_abnormal_urinary_bladder0.76903529
74MP0003690_abnormal_glial_cell0.75253472
75MP0000026_abnormal_inner_ear0.75051590
76MP0001485_abnormal_pinna_reflex0.74856630
77MP0003632_abnormal_nervous_system0.73402946
78MP0000920_abnormal_myelination0.72989101
79MP0004264_abnormal_extraembryonic_tissu0.71899440
80MP0003861_abnormal_nervous_system0.71745116
81MP0002752_abnormal_somatic_nervous0.70450798
82MP0003942_abnormal_urinary_system0.68604325
83MP0000631_abnormal_neuroendocrine_gland0.67112272
84MP0005623_abnormal_meninges_morphology0.66424840
85MP0009379_abnormal_foot_pigmentation0.64960872
86MP0003634_abnormal_glial_cell0.63386489
87MP0000383_abnormal_hair_follicle0.62681536
88MP0005187_abnormal_penis_morphology0.61183992
89MP0002638_abnormal_pupillary_reflex0.59683414
90MP0002069_abnormal_eating/drinking_beha0.58961059
91MP0010770_preweaning_lethality0.58648690
92MP0002082_postnatal_lethality0.58648690
93MP0010769_abnormal_survival0.58067294
94MP0010030_abnormal_orbit_morphology0.57860093
95MP0005551_abnormal_eye_electrophysiolog0.57108297
96MP0002249_abnormal_larynx_morphology0.55869543
97MP0010768_mortality/aging0.55001383
98MP0000604_amyloidosis0.53976193
99MP0003937_abnormal_limbs/digits/tail_de0.53001570
100MP0004742_abnormal_vestibular_system0.52157878

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.91507736
2Myokymia (HP:0002411)6.58700556
3Focal seizures (HP:0007359)5.36060382
4Atonic seizures (HP:0010819)5.10344779
5Oligodactyly (hands) (HP:0001180)4.87133998
6Ankle clonus (HP:0011448)4.54222909
7Double outlet right ventricle (HP:0001719)4.23675670
8Congenital malformation of the right heart (HP:0011723)4.23675670
9Aqueductal stenosis (HP:0002410)4.03918775
10Epileptic encephalopathy (HP:0200134)4.02644266
11Action tremor (HP:0002345)3.93468237
12Oligodactyly (HP:0012165)3.84762387
13Febrile seizures (HP:0002373)3.80071534
14Abnormality of the parathyroid morphology (HP:0011766)3.73590573
15Dialeptic seizures (HP:0011146)3.72316521
16Intestinal atresia (HP:0011100)3.67614917
17Esophageal atresia (HP:0002032)3.55410759
18Generalized tonic-clonic seizures (HP:0002069)3.55337361
19Mutism (HP:0002300)3.46635642
20Mixed hearing impairment (HP:0000410)3.27821872
21Chin dimple (HP:0010751)3.25507580
22Supranuclear gaze palsy (HP:0000605)3.09522563
23Spastic gait (HP:0002064)3.06170768
24Truncal ataxia (HP:0002078)3.03263529
25Urinary urgency (HP:0000012)2.98754098
26Absence seizures (HP:0002121)2.91013277
27Impaired vibration sensation in the lower limbs (HP:0002166)2.85286391
28Abnormal eating behavior (HP:0100738)2.79967874
29Abnormality of the corticospinal tract (HP:0002492)2.79332775
30Aplasia involving bones of the upper limbs (HP:0009823)2.79156574
31Aplasia of the phalanges of the hand (HP:0009802)2.79156574
32Aplasia involving bones of the extremities (HP:0009825)2.79156574
33Abnormality of cochlea (HP:0000375)2.78838786
34Progressive cerebellar ataxia (HP:0002073)2.77303976
35Torticollis (HP:0000473)2.77277383
36Akinesia (HP:0002304)2.75100771
37Postural instability (HP:0002172)2.73401904
38Fetal akinesia sequence (HP:0001989)2.69028107
39Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.64873122
40Degeneration of the lateral corticospinal tracts (HP:0002314)2.64873122
41Anophthalmia (HP:0000528)2.63171332
42Neurofibrillary tangles (HP:0002185)2.61607684
43Amblyopia (HP:0000646)2.59370965
44Urinary bladder sphincter dysfunction (HP:0002839)2.56891572
45Abnormality of binocular vision (HP:0011514)2.53679046
46Diplopia (HP:0000651)2.53679046
47Status epilepticus (HP:0002133)2.53661114
48Limb dystonia (HP:0002451)2.50704136
49Lower limb muscle weakness (HP:0007340)2.42811129
50Deep palmar crease (HP:0006191)2.39603517
51Dysmetria (HP:0001310)2.36245996
52Split foot (HP:0001839)2.33669112
53Gastrointestinal atresia (HP:0002589)2.33575412
54Neuronal loss in central nervous system (HP:0002529)2.30261451
55Down-sloping shoulders (HP:0200021)2.29839999
56Focal dystonia (HP:0004373)2.29677093
57Dysdiadochokinesis (HP:0002075)2.28652479
58Morphological abnormality of the inner ear (HP:0011390)2.26886351
59Depression (HP:0000716)2.25896008
60Labial hypoplasia (HP:0000066)2.21971274
61Epileptiform EEG discharges (HP:0011182)2.21613714
62Partial duplication of thumb phalanx (HP:0009944)2.20703926
63Clonus (HP:0002169)2.17314855
64Craniofacial dystonia (HP:0012179)2.14528413
65Cerebral inclusion bodies (HP:0100314)2.11056857
66Bradykinesia (HP:0002067)2.08941868
67Intention tremor (HP:0002080)2.05488707
68Alacrima (HP:0000522)2.05025158
69Delusions (HP:0000746)2.00568929
70Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.00154674
71Hypoplastic female external genitalia (HP:0012815)1.99812057
72Impaired vibratory sensation (HP:0002495)1.98580439
73Partial duplication of the phalanx of hand (HP:0009999)1.98157837
74Anxiety (HP:0000739)1.97889105
75Annular pancreas (HP:0001734)1.97886786
76Anosmia (HP:0000458)1.94588987
77Pheochromocytoma (HP:0002666)1.93015048
78Polyphagia (HP:0002591)1.90101497
79Sleep apnea (HP:0010535)1.89814615
80Morphological abnormality of the pyramidal tract (HP:0002062)1.87886574
81Anal stenosis (HP:0002025)1.87181534
82Absent radius (HP:0003974)1.87117161
83Hypoplasia of the ulna (HP:0003022)1.85871064
84Cupped ear (HP:0000378)1.84589919
85Hemiplegia (HP:0002301)1.84281021
86Cerebral hypomyelination (HP:0006808)1.83735727
87Poor suck (HP:0002033)1.83690879
88Incomplete penetrance (HP:0003829)1.83642942
89Renal hypoplasia (HP:0000089)1.83074458
90EEG with generalized epileptiform discharges (HP:0011198)1.80849022
91Broad-based gait (HP:0002136)1.80727382
92Gaze-evoked nystagmus (HP:0000640)1.79601673
93Impaired smooth pursuit (HP:0007772)1.77126113
94Apathy (HP:0000741)1.76644388
95Bilateral microphthalmos (HP:0007633)1.75637518
96Aplasia involving forearm bones (HP:0009822)1.75152191
97Absent forearm bone (HP:0003953)1.75152191
98Poor eye contact (HP:0000817)1.74139839
99Tetraplegia (HP:0002445)1.72715578
100Hypsarrhythmia (HP:0002521)1.71172801

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.12730198
2MARK13.43321978
3NTRK33.42521801
4CASK3.12994700
5PAK62.88244680
6CDK192.81403945
7MAP3K92.78108885
8DAPK22.62403429
9NTRK22.40370009
10MINK12.20355371
11NTRK12.18175259
12ARAF1.88916786
13PLK41.88154010
14PIK3CA1.78921582
15UHMK11.73462327
16FGFR21.70373645
17NME11.65953134
18PRKD31.65295895
19CAMKK11.61769303
20MAP4K21.54249613
21CCNB11.53061959
22CAMK11.52886066
23CAMK2B1.52875817
24LATS21.51338536
25WNK31.45652656
26PLK21.43828480
27MAP3K121.43095942
28PRKCG1.38898515
29PNCK1.38669978
30SIK21.31763166
31NEK61.29850418
32CDK51.29253910
33MAP2K71.28589373
34DAPK11.28555625
35SIK31.22900154
36TRIM281.19379269
37CAMK1G1.18013808
38CAMK2A1.11958740
39PHKG21.07572072
40PHKG11.07572072
41CDK181.07100574
42SGK4941.03533511
43SGK2231.03533511
44CDK151.02138853
45CSNK1G21.01412614
46TESK11.00370607
47CDK11A0.95572820
48GRK50.94895401
49CAMK2G0.93827435
50OXSR10.92531248
51CDK140.91614074
52MAP3K40.89434731
53PAK30.88719035
54PINK10.84953850
55LIMK10.84312627
56STK380.83401309
57SCYL20.83232704
58MAP2K40.82662993
59MARK20.82347668
60BCR0.76862175
61ALK0.76553868
62TYRO30.76034328
63DYRK1A0.75082510
64MAPK130.74974340
65MAP2K10.74436019
66CAMK2D0.74270375
67TNIK0.72392679
68CSNK1G30.64986404
69BRSK10.61385251
70CAMK1D0.59581957
71RET0.59426337
72KSR20.59384515
73PRKCH0.58956891
74CSNK1A1L0.53378820
75CSNK1G10.52874922
76PDPK10.51625373
77PRKCZ0.51313995
78PDK10.50958008
79MAPK120.49837252
80SGK10.49659190
81PRKCE0.48226704
82MAPK100.47622227
83RPS6KA30.47611772
84LMTK20.47210487
85SGK20.45945650
86DAPK30.45455157
87SIK10.44798957
88KSR10.42124196
89AKT30.40987200
90PRKCA0.40754251
91ROCK20.40541323
92PRKG10.38535658
93BRAF0.38508649
94MUSK0.38015280
95PRPF4B0.37328377
96RPS6KB10.35854710
97MAP2K20.35291499
98CSNK1A10.34657839
99STK110.34265193
100BMPR20.34160066

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.82755906
2Synaptic vesicle cycle_Homo sapiens_hsa047213.74777605
3GABAergic synapse_Homo sapiens_hsa047273.37486375
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.03716529
5Morphine addiction_Homo sapiens_hsa050322.98176014
6Long-term potentiation_Homo sapiens_hsa047202.67913410
7Circadian entrainment_Homo sapiens_hsa047132.45079420
8Glutamatergic synapse_Homo sapiens_hsa047242.33015211
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.30052216
10Amphetamine addiction_Homo sapiens_hsa050312.25800155
11* Taste transduction_Homo sapiens_hsa047422.16625890
12Insulin secretion_Homo sapiens_hsa049112.05980939
13Gastric acid secretion_Homo sapiens_hsa049711.90406361
14Dopaminergic synapse_Homo sapiens_hsa047281.86961354
15Cocaine addiction_Homo sapiens_hsa050301.78612894
16Cardiac muscle contraction_Homo sapiens_hsa042601.76397877
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69053053
18Collecting duct acid secretion_Homo sapiens_hsa049661.66049086
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63164927
20Salivary secretion_Homo sapiens_hsa049701.56850786
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53742572
22Cholinergic synapse_Homo sapiens_hsa047251.52055629
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50843664
24Vibrio cholerae infection_Homo sapiens_hsa051101.44547736
25Oxytocin signaling pathway_Homo sapiens_hsa049211.27025538
26Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.23392535
27Calcium signaling pathway_Homo sapiens_hsa040201.23005894
28* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19633465
29* cAMP signaling pathway_Homo sapiens_hsa040241.18625523
30Axon guidance_Homo sapiens_hsa043601.15571355
31Melanogenesis_Homo sapiens_hsa049161.14169892
32* Serotonergic synapse_Homo sapiens_hsa047261.11300145
33Gap junction_Homo sapiens_hsa045401.09816938
34Long-term depression_Homo sapiens_hsa047301.09574729
35Renin secretion_Homo sapiens_hsa049241.09161831
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06841335
37Oxidative phosphorylation_Homo sapiens_hsa001901.05295428
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04081441
39Vitamin B6 metabolism_Homo sapiens_hsa007500.96031504
40Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95285820
41Olfactory transduction_Homo sapiens_hsa047400.95112142
42Alzheimers disease_Homo sapiens_hsa050100.94199254
43Oocyte meiosis_Homo sapiens_hsa041140.93789946
44Fatty acid elongation_Homo sapiens_hsa000620.91626938
45Estrogen signaling pathway_Homo sapiens_hsa049150.90246673
46GnRH signaling pathway_Homo sapiens_hsa049120.89168843
47Wnt signaling pathway_Homo sapiens_hsa043100.83189505
48Glioma_Homo sapiens_hsa052140.82929523
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81985561
50Pancreatic secretion_Homo sapiens_hsa049720.81692201
51Parkinsons disease_Homo sapiens_hsa050120.81435061
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81331849
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76640170
54Thyroid hormone synthesis_Homo sapiens_hsa049180.73818380
55Hedgehog signaling pathway_Homo sapiens_hsa043400.72157954
56Hippo signaling pathway_Homo sapiens_hsa043900.70893206
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70124033
58ErbB signaling pathway_Homo sapiens_hsa040120.69799598
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.66434480
60Tight junction_Homo sapiens_hsa045300.64510609
61Rap1 signaling pathway_Homo sapiens_hsa040150.58928599
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58079928
63Huntingtons disease_Homo sapiens_hsa050160.56908100
64Glucagon signaling pathway_Homo sapiens_hsa049220.56036682
65Bile secretion_Homo sapiens_hsa049760.54730459
66Ras signaling pathway_Homo sapiens_hsa040140.54362670
67Endometrial cancer_Homo sapiens_hsa052130.52227209
68Phototransduction_Homo sapiens_hsa047440.51848626
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.48989924
70Regulation of autophagy_Homo sapiens_hsa041400.47708171
71Basal cell carcinoma_Homo sapiens_hsa052170.47633532
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47063992
73Inositol phosphate metabolism_Homo sapiens_hsa005620.46545074
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45838779
75Dilated cardiomyopathy_Homo sapiens_hsa054140.43453048
76VEGF signaling pathway_Homo sapiens_hsa043700.43335432
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41993887
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.41443482
79MAPK signaling pathway_Homo sapiens_hsa040100.40554612
80Arginine and proline metabolism_Homo sapiens_hsa003300.39768612
81Type II diabetes mellitus_Homo sapiens_hsa049300.39750616
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.35399178
83Alcoholism_Homo sapiens_hsa050340.34592159
84Prion diseases_Homo sapiens_hsa050200.34457082
85AMPK signaling pathway_Homo sapiens_hsa041520.34177764
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34128161
87Insulin signaling pathway_Homo sapiens_hsa049100.33431020
88Endocytosis_Homo sapiens_hsa041440.33053925
89Choline metabolism in cancer_Homo sapiens_hsa052310.32374084
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31938653
91Mineral absorption_Homo sapiens_hsa049780.31393818
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30315809
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28763030
94Protein digestion and absorption_Homo sapiens_hsa049740.26744971
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26734268
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25826803
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25137105
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23269280
99Renal cell carcinoma_Homo sapiens_hsa052110.23188103
100Circadian rhythm_Homo sapiens_hsa047100.21537119

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