HTR1F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)5.55760570
2negative regulation of synaptic transmission, GABAergic (GO:0032229)5.30669821
3cell wall macromolecule metabolic process (GO:0044036)5.28501217
4neuronal action potential propagation (GO:0019227)5.23120076
5aggressive behavior (GO:0002118)5.22782241
6synaptic vesicle exocytosis (GO:0016079)5.19473938
7vocalization behavior (GO:0071625)4.95535085
8neuron cell-cell adhesion (GO:0007158)4.92524564
9glutamate secretion (GO:0014047)4.92078907
10protein localization to synapse (GO:0035418)4.81585876
11definitive hemopoiesis (GO:0060216)4.76496508
12gamma-aminobutyric acid signaling pathway (GO:0007214)4.73630126
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.66843869
14presynaptic membrane assembly (GO:0097105)4.63630464
15regulation of synaptic vesicle exocytosis (GO:2000300)4.61238350
16positive regulation of histone H3-K4 methylation (GO:0051571)4.58695559
17glutamate receptor signaling pathway (GO:0007215)4.57745057
18rRNA methylation (GO:0031167)4.52337178
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.42801546
20neuron-neuron synaptic transmission (GO:0007270)4.42074355
21regulation of short-term neuronal synaptic plasticity (GO:0048172)4.39886951
22presynaptic membrane organization (GO:0097090)4.38164355
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.33093678
24positive regulation of glycolytic process (GO:0045821)4.31345980
25ATP hydrolysis coupled proton transport (GO:0015991)4.31171498
26energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.31171498
27rRNA modification (GO:0000154)4.27632343
28negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.18461602
29synaptic transmission, glutamatergic (GO:0035249)4.17072086
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.11804583
31negative regulation of gluconeogenesis (GO:0045721)4.11787050
32synaptic vesicle docking involved in exocytosis (GO:0016081)4.09354812
33behavioral response to cocaine (GO:0048148)4.04738904
34histamine secretion (GO:0001821)4.01376924
35response to histamine (GO:0034776)4.01009171
36transferrin transport (GO:0033572)3.98243993
37negative regulation of dendrite morphogenesis (GO:0050774)3.97422298
38organelle membrane fusion (GO:0090174)3.96327421
39regulation of synaptic vesicle transport (GO:1902803)3.95250762
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.93996178
41regulation of glutamate receptor signaling pathway (GO:1900449)3.93121933
42autophagic vacuole fusion (GO:0000046)3.91619614
43nitric oxide mediated signal transduction (GO:0007263)3.89494239
44DNA deamination (GO:0045006)3.89162291
45negative regulation of acute inflammatory response (GO:0002674)3.87736381
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.86646149
47neuron recognition (GO:0008038)3.82013259
48regulation of B cell apoptotic process (GO:0002902)3.81524024
49long-term synaptic potentiation (GO:0060291)3.78756917
50G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.75532744
51negative regulation of neurological system process (GO:0031645)3.72955913
52regulation of postsynaptic membrane potential (GO:0060078)3.72206000
53maternal behavior (GO:0042711)3.71486650
54ferric iron transport (GO:0015682)3.70358180
55trivalent inorganic cation transport (GO:0072512)3.70358180
56inositol phosphate catabolic process (GO:0071545)3.69147460
57inositol phosphate dephosphorylation (GO:0046855)3.64927728
58phosphorylated carbohydrate dephosphorylation (GO:0046838)3.64927728
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.62622667
60behavioral fear response (GO:0001662)3.62062526
61behavioral defense response (GO:0002209)3.62062526
62regulation of glutamate secretion (GO:0014048)3.60800570
63cellular ketone body metabolic process (GO:0046950)3.60373128
64negative regulation of protein oligomerization (GO:0032460)3.57279501
65parental behavior (GO:0060746)3.56560941
66regulation of type B pancreatic cell apoptotic process (GO:2000674)3.56347688
67positive regulation of synapse maturation (GO:0090129)3.55877654
68axonal fasciculation (GO:0007413)3.55744458
69mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.55296648
70negative regulation of dendrite development (GO:2000171)3.54919756
71proline transport (GO:0015824)3.54651490
72postsynaptic membrane organization (GO:0001941)3.51522220
73neurotransmitter-gated ion channel clustering (GO:0072578)3.50754819
74regulation of long-term neuronal synaptic plasticity (GO:0048169)3.47126570
75positive regulation of vasculogenesis (GO:2001214)3.46886224
76endothelium development (GO:0003158)3.46851424
77neurotransmitter secretion (GO:0007269)3.46135266
78regulation of synaptic transmission, glutamatergic (GO:0051966)3.45307938
79branched-chain amino acid catabolic process (GO:0009083)3.44762921
80synaptic vesicle maturation (GO:0016188)3.41166407
81preassembly of GPI anchor in ER membrane (GO:0016254)3.39359915
82fear response (GO:0042596)3.36476136
83protein localization to cilium (GO:0061512)3.35341778
84positive regulation of neurotransmitter secretion (GO:0001956)3.33987380
85regulation of synaptic plasticity (GO:0048167)3.30939397
86regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.29483469
87exploration behavior (GO:0035640)3.29234117
88endocrine pancreas development (GO:0031018)3.28627011
89positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.26436449
90deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.25122365
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.23943729
92glucosamine-containing compound catabolic process (GO:1901072)3.23909937
93regulation of neuronal synaptic plasticity (GO:0048168)3.23406885
94branched-chain amino acid metabolic process (GO:0009081)3.20969404
95seminiferous tubule development (GO:0072520)3.19618968
96ATP synthesis coupled proton transport (GO:0015986)3.19525269
97energy coupled proton transport, down electrochemical gradient (GO:0015985)3.19525269
98insulin secretion (GO:0030073)3.19211612
99negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.18608065
100regulation of vesicle fusion (GO:0031338)3.17719894
101long term synaptic depression (GO:0060292)3.17561882
102membrane depolarization (GO:0051899)3.16853743
103xenobiotic catabolic process (GO:0042178)3.15988394
104chemosensory behavior (GO:0007635)3.15755304
105negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.15472959
106ketone body metabolic process (GO:1902224)3.14678956
107positive regulation of neurotransmitter transport (GO:0051590)3.14006575
108histamine transport (GO:0051608)3.12734260
109positive regulation of membrane potential (GO:0045838)3.12255105
110synaptic vesicle endocytosis (GO:0048488)3.11558178
111* serotonin receptor signaling pathway (GO:0007210)3.10850821
112regulation of neurotransmitter secretion (GO:0046928)3.10145277
113locomotory exploration behavior (GO:0035641)3.09851461
114G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.09758810
115detection of calcium ion (GO:0005513)3.08656521
116striatum development (GO:0021756)3.06935713
117regulation of voltage-gated calcium channel activity (GO:1901385)3.06847129
118regulation of synapse structural plasticity (GO:0051823)3.05125034
119chaperone-mediated protein transport (GO:0072321)3.04717025
120urinary tract smooth muscle contraction (GO:0014848)3.04224938
121regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.03991296
122regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.03991296
123type B pancreatic cell development (GO:0003323)3.03179137
124dentate gyrus development (GO:0021542)3.02565885
125NADH metabolic process (GO:0006734)3.01596290
126estrogen biosynthetic process (GO:0006703)2.97431774
127regulation of protein kinase A signaling (GO:0010738)2.97062607
128positive regulation of insulin secretion (GO:0032024)2.96951055
129phagosome maturation (GO:0090382)2.96566341
130protein K6-linked ubiquitination (GO:0085020)2.96268680
131serotonin metabolic process (GO:0042428)2.95977941
132mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95509458
133membrane depolarization during action potential (GO:0086010)2.95492377
134cerebellar Purkinje cell differentiation (GO:0021702)2.93865488
135regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.92860667
136gamma-aminobutyric acid transport (GO:0015812)2.92734698
137negative regulation of synaptic transmission (GO:0050805)2.91644171
138cerebellar granule cell differentiation (GO:0021707)2.91415665
139positive regulation of cardiac muscle hypertrophy (GO:0010613)2.90779747
140positive regulation of muscle hypertrophy (GO:0014742)2.90779747
141mechanosensory behavior (GO:0007638)2.90643823
142regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.89524172
143startle response (GO:0001964)2.89486869
144neurotransmitter transport (GO:0006836)2.88475698
145* synaptic transmission (GO:0007268)2.87442755
146valine metabolic process (GO:0006573)2.87424164
147regulation of protein glycosylation (GO:0060049)2.86743158
148positive regulation of peptide hormone secretion (GO:0090277)2.86104679
149GPI anchor biosynthetic process (GO:0006506)2.85735681
150transmission of nerve impulse (GO:0019226)2.84173398
151learning (GO:0007612)2.84008402
152positive regulation of synapse assembly (GO:0051965)2.82764401
153RNA destabilization (GO:0050779)2.78665263
154grooming behavior (GO:0007625)2.78626293
155peptidyl-threonine dephosphorylation (GO:0035970)2.78004502
156regulation of transmission of nerve impulse (GO:0051969)2.77155078
157positive regulation of TOR signaling (GO:0032008)2.75920005
158negative regulation of erythrocyte differentiation (GO:0045647)2.73077497
159positive regulation of granulocyte differentiation (GO:0030854)2.72821258
160positive regulation of peptide secretion (GO:0002793)2.72501163
161polyol catabolic process (GO:0046174)2.71556990
162water-soluble vitamin biosynthetic process (GO:0042364)2.67208111
163regulation of glucokinase activity (GO:0033131)2.64048237
164regulation of hexokinase activity (GO:1903299)2.64048237
165phosphatidylinositol acyl-chain remodeling (GO:0036149)2.62049367
166mannosylation (GO:0097502)2.60691660
167positive regulation of respiratory burst (GO:0060267)2.58964795
168L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.58829066
169GPI anchor metabolic process (GO:0006505)2.58229790
170GMP metabolic process (GO:0046037)2.57495977
171zinc ion transmembrane transport (GO:0071577)2.56413152
172C-terminal protein lipidation (GO:0006501)2.55684885
173protein complex biogenesis (GO:0070271)2.55430783
174monoamine transport (GO:0015844)2.51440878
175cardiolipin metabolic process (GO:0032048)2.49080015
176protein K11-linked deubiquitination (GO:0035871)2.48886466
177regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.48716341
178purine nucleotide salvage (GO:0032261)2.48547742
179piRNA metabolic process (GO:0034587)2.47234842
180cytochrome complex assembly (GO:0017004)2.47023720
181glandular epithelial cell differentiation (GO:0002067)2.46960841
182positive regulation of protein homodimerization activity (GO:0090073)2.43941671
183purine-containing compound salvage (GO:0043101)2.43311759
184succinate metabolic process (GO:0006105)2.42986630
185regulation of histone H3-K4 methylation (GO:0051569)2.41857251
186regulation of vasculogenesis (GO:2001212)2.40922128
187cell differentiation involved in metanephros development (GO:0072202)2.40145140
188single strand break repair (GO:0000012)2.39042964
189positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.38834579
190phosphatidylserine acyl-chain remodeling (GO:0036150)2.38833304
191regulation of penile erection (GO:0060405)2.36806013
192forebrain morphogenesis (GO:0048853)2.35969943
193negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.35886867
194zinc ion transport (GO:0006829)2.33524573
195azole transport (GO:0045117)2.33087057
196macroautophagy (GO:0016236)2.32492884
197lactate metabolic process (GO:0006089)2.32452202
198regulation of female receptivity (GO:0045924)2.31210369
199positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.27923149
200regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.27923149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.39365494
2EZH2_22144423_ChIP-Seq_EOC_Human6.02348352
3GBX2_23144817_ChIP-Seq_PC3_Human4.46920748
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.80221752
5* TAF15_26573619_Chip-Seq_HEK293_Human3.34169204
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19361406
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95675096
8GATA1_22025678_ChIP-Seq_K562_Human2.90342811
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89977090
10SCL_19346495_ChIP-Seq_HPC-7_Human2.70049651
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.63679799
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62541809
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52767620
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.45869091
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.42153431
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.40846982
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39643549
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39643549
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.37870483
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37360629
21* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36767011
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36277107
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24431787
24* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23519757
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.23436541
26P300_19829295_ChIP-Seq_ESCs_Human2.19446229
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19345798
28VDR_22108803_ChIP-Seq_LS180_Human2.18222975
29SMAD4_21799915_ChIP-Seq_A2780_Human2.07315239
30RARB_27405468_Chip-Seq_BRAIN_Mouse2.06508185
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99995988
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98877675
33* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98414282
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98154162
35* FUS_26573619_Chip-Seq_HEK293_Human1.98044529
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93708725
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90857849
38AR_21572438_ChIP-Seq_LNCaP_Human1.90163142
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.89425531
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88891286
41* RNF2_27304074_Chip-Seq_ESCs_Mouse1.85827461
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.85310975
43* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82772403
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80165224
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.78953275
46VDR_23849224_ChIP-Seq_CD4+_Human1.77832257
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76952192
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75568978
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.74065144
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.73857755
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71405909
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69292758
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.69217406
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.67169113
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.64167423
56DROSHA_22980978_ChIP-Seq_HELA_Human1.63755632
57* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59504437
58AR_25329375_ChIP-Seq_VCAP_Human1.57360736
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55152278
60AR_20517297_ChIP-Seq_VCAP_Human1.52908500
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52122076
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51231898
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49487041
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49255985
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48802827
66TP53_22573176_ChIP-Seq_HFKS_Human1.48664862
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48524088
68* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47069794
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.44789348
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.44442228
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42652366
72BCAT_22108803_ChIP-Seq_LS180_Human1.42006761
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41598004
74EST1_17652178_ChIP-ChIP_JURKAT_Human1.41515836
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41471684
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40365735
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.40365735
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.40070472
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36342676
80ZNF274_21170338_ChIP-Seq_K562_Hela1.35661355
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35297957
82SOX2_19829295_ChIP-Seq_ESCs_Human1.35091735
83NANOG_19829295_ChIP-Seq_ESCs_Human1.35091735
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34467308
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34279556
86JUN_21703547_ChIP-Seq_K562_Human1.34176535
87FOXP3_21729870_ChIP-Seq_TREG_Human1.33610579
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33300963
89STAT3_23295773_ChIP-Seq_U87_Human1.32471702
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.32301768
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30058829
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28990877
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28912356
94RNF2_27304074_Chip-Seq_NSC_Mouse1.27311282
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.26454125
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.25075983
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23906567
98* TCF4_23295773_ChIP-Seq_U87_Human1.23712470
99TP53_16413492_ChIP-PET_HCT116_Human1.22715388
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21864670
101TP53_18474530_ChIP-ChIP_U2OS_Human1.21546038
102IGF1R_20145208_ChIP-Seq_DFB_Human1.21370547
103ETS1_20019798_ChIP-Seq_JURKAT_Human1.20579775
104ER_23166858_ChIP-Seq_MCF-7_Human1.19812978
105PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18815963
106HTT_18923047_ChIP-ChIP_STHdh_Human1.18422839
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16943047
108* RUNX2_22187159_ChIP-Seq_PCA_Human1.16897617
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15126903
110KDM2B_26808549_Chip-Seq_REH_Human1.14970498
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.14703867
112ERG_21242973_ChIP-ChIP_JURKAT_Human1.13916971
113MYC_18940864_ChIP-ChIP_HL60_Human1.13769595
114SALL1_21062744_ChIP-ChIP_HESCs_Human1.13348552
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.12440613
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12011977
117MYB_26560356_Chip-Seq_TH2_Human1.11286410
118HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09912936
119ELK1_19687146_ChIP-ChIP_HELA_Human1.09716615
120GATA3_26560356_Chip-Seq_TH2_Human1.09572397
121FLI1_27457419_Chip-Seq_LIVER_Mouse1.07900667
122ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07198197
123WT1_19549856_ChIP-ChIP_CCG9911_Human1.05697524
124CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05399971
125LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05084190
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05067140
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05067140
128SOX9_26525672_Chip-Seq_HEART_Mouse1.03481230
129CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03427107
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03097165
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02699936
132CRX_20693478_ChIP-Seq_RETINA_Mouse1.02476511
133NFE2_27457419_Chip-Seq_LIVER_Mouse1.02298015
134FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02270678
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02171195
136MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02113643
137GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01772256
138SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01456669
139GATA3_27048872_Chip-Seq_THYMUS_Human1.01210318
140E2F1_18555785_Chip-Seq_ESCs_Mouse1.01079971
141CDX2_22108803_ChIP-Seq_LS180_Human1.00628902
142P53_22387025_ChIP-Seq_ESCs_Mouse1.00570577
143GATA3_21878914_ChIP-Seq_MCF-7_Human1.00366762
144JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99527036
145ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99193503
146CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99141292
147ERG_20517297_ChIP-Seq_VCAP_Human0.99118284
148PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98637374
149BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98486825
150CBP_20019798_ChIP-Seq_JUKART_Human0.98215995
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98215995
152SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97226011
153YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96843711
154AHR_22903824_ChIP-Seq_MCF-7_Human0.96211530
155AR_19668381_ChIP-Seq_PC3_Human0.95781807
156* EWS_26573619_Chip-Seq_HEK293_Human0.95633499
157CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95565638
158ETS1_22383799_ChIP-Seq_G1ME_Mouse0.95517661
159EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93346074
160CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92948066
161GATA2_21666600_ChIP-Seq_HMVEC_Human0.92848057
162* FLI1_21867929_ChIP-Seq_TH2_Mouse0.91730154
163GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90600985
164SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88322554
165NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.87070565
166STAT3_18555785_Chip-Seq_ESCs_Mouse0.85568055
167CMYC_18555785_Chip-Seq_ESCs_Mouse0.84852389
168P300_18555785_Chip-Seq_ESCs_Mouse0.84343629

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.74041070
2MP0004859_abnormal_synaptic_plasticity5.34110890
3MP0004270_analgesia4.31557403
4* MP0003635_abnormal_synaptic_transmissio3.92432637
5MP0001968_abnormal_touch/_nociception3.88075209
6MP0009745_abnormal_behavioral_response3.60917975
7MP0002064_seizures3.42944076
8MP0002736_abnormal_nociception_after3.38189429
9MP0002063_abnormal_learning/memory/cond3.31532671
10MP0009046_muscle_twitch3.25277846
11MP0003195_calcinosis3.12748591
12MP0002572_abnormal_emotion/affect_behav3.05718369
13MP0001501_abnormal_sleep_pattern2.83485135
14MP0002272_abnormal_nervous_system2.83128484
15MP0002734_abnormal_mechanical_nocicepti2.80324357
16MP0002735_abnormal_chemical_nociception2.72129888
17MP0003283_abnormal_digestive_organ2.66864992
18MP0005645_abnormal_hypothalamus_physiol2.56379646
19MP0001486_abnormal_startle_reflex2.47233526
20MP0001440_abnormal_grooming_behavior2.43866225
21MP0002396_abnormal_hematopoietic_system2.40884219
22MP0004147_increased_porphyrin_level2.38314522
23MP0003718_maternal_effect2.35408769
24MP0002067_abnormal_sensory_capabilities2.32129967
25MP0002837_dystrophic_cardiac_calcinosis2.14035016
26* MP0002733_abnormal_thermal_nociception2.13657435
27MP0002693_abnormal_pancreas_physiology2.11462831
28MP0005397_hematopoietic_system_phenotyp2.11374244
29MP0001545_abnormal_hematopoietic_system2.11374244
30MP0001529_abnormal_vocalization2.10569366
31MP0004808_abnormal_hematopoietic_stem2.09382773
32MP0006276_abnormal_autonomic_nervous2.05610130
33MP0005084_abnormal_gallbladder_morpholo2.04041452
34MP0006072_abnormal_retinal_apoptosis2.02769763
35MP0001944_abnormal_pancreas_morphology2.02199598
36* MP0001970_abnormal_pain_threshold2.01873089
37MP0005220_abnormal_exocrine_pancreas2.00803293
38MP0009697_abnormal_copulation1.90482555
39MP0005464_abnormal_platelet_physiology1.88582813
40MP0003806_abnormal_nucleotide_metabolis1.84863110
41MP0005379_endocrine/exocrine_gland_phen1.79327643
42MP0001984_abnormal_olfaction1.77407497
43MP0004924_abnormal_behavior1.77011940
44MP0005386_behavior/neurological_phenoty1.77011940
45MP0003656_abnormal_erythrocyte_physiolo1.76655656
46MP0003879_abnormal_hair_cell1.74612198
47MP0002184_abnormal_innervation1.71384524
48MP0003172_abnormal_lysosome_physiology1.71309722
49MP0000778_abnormal_nervous_system1.66454269
50MP0001905_abnormal_dopamine_level1.64545622
51MP0003329_amyloid_beta_deposits1.61094221
52MP0004142_abnormal_muscle_tone1.60176062
53MP0000516_abnormal_urinary_system1.55722826
54MP0005367_renal/urinary_system_phenotyp1.55722826
55MP0001764_abnormal_homeostasis1.53543890
56MP0003787_abnormal_imprinting1.52702789
57MP0002557_abnormal_social/conspecific_i1.51787469
58MP0008569_lethality_at_weaning1.46260303
59MP0002139_abnormal_hepatobiliary_system1.45011529
60MP0000465_gastrointestinal_hemorrhage1.41944120
61MP0004858_abnormal_nervous_system1.41393176
62MP0002066_abnormal_motor_capabilities/c1.40612371
63MP0001986_abnormal_taste_sensitivity1.40585190
64MP0004811_abnormal_neuron_physiology1.38922617
65MP0005636_abnormal_mineral_homeostasis1.36039696
66MP0002882_abnormal_neuron_morphology1.27171014
67MP0000955_abnormal_spinal_cord1.26337691
68MP0004484_altered_response_of1.26235721
69MP0001661_extended_life_span1.24792351
70MP0001835_abnormal_antigen_presentation1.22289753
71MP0002078_abnormal_glucose_homeostasis1.21697596
72MP0000751_myopathy1.21632907
73MP0002009_preneoplasia1.21019085
74MP0008872_abnormal_physiological_respon1.20416499
75MP0002876_abnormal_thyroid_physiology1.20230778
76MP0009780_abnormal_chondrocyte_physiolo1.16482057
77MP0003122_maternal_imprinting1.16097129
78MP0002166_altered_tumor_susceptibility1.15700788
79MP0008775_abnormal_heart_ventricle1.15504061
80MP0010386_abnormal_urinary_bladder1.14866566
81MP0005646_abnormal_pituitary_gland1.14278718
82MP0005171_absent_coat_pigmentation1.13023942
83MP0004145_abnormal_muscle_electrophysio1.11652511
84MP0010329_abnormal_lipoprotein_level1.11538601
85MP0005253_abnormal_eye_physiology1.11437381
86MP0003633_abnormal_nervous_system1.11099823
87MP0005423_abnormal_somatic_nervous1.10600199
88MP0002234_abnormal_pharynx_morphology1.08954525
89MP0002822_catalepsy1.08487684
90MP0001756_abnormal_urination1.06832812
91MP0001188_hyperpigmentation1.06613246
92MP0005332_abnormal_amino_acid1.06278480
93MP0000230_abnormal_systemic_arterial1.06263653
94MP0008874_decreased_physiological_sensi1.06240136
95MP0002160_abnormal_reproductive_system1.06054264
96MP0002909_abnormal_adrenal_gland1.05297894
97MP0005389_reproductive_system_phenotype1.04267822
98MP0002928_abnormal_bile_duct1.03680446
99MP0008875_abnormal_xenobiotic_pharmacok1.03301034
100MP0008058_abnormal_DNA_repair1.02731979
101MP0003252_abnormal_bile_duct1.01897067
102MP0003631_nervous_system_phenotype1.01244998
103MP0008995_early_reproductive_senescence1.00124416
104MP0003724_increased_susceptibility_to0.99478353
105MP0000681_abnormal_thyroid_gland0.99454316
106MP0003075_altered_response_to0.98497268
107MP0009643_abnormal_urine_homeostasis0.98234793
108MP0004215_abnormal_myocardial_fiber0.96772312
109MP0002118_abnormal_lipid_homeostasis0.96461817
110MP0004085_abnormal_heartbeat0.95681515
111MP0003943_abnormal_hepatobiliary_system0.95437385
112MP0004510_myositis0.94715773
113MP0000013_abnormal_adipose_tissue0.94541993
114MP0001963_abnormal_hearing_physiology0.94534060
115MP0003186_abnormal_redox_activity0.94483471
116MP0009278_abnormal_bone_marrow0.94137873
117MP0002152_abnormal_brain_morphology0.91992332
118MP0002229_neurodegeneration0.91833461
119MP0005394_taste/olfaction_phenotype0.91511071
120MP0005499_abnormal_olfactory_system0.91511071
121MP0003953_abnormal_hormone_level0.90152980
122MP0003121_genomic_imprinting0.90021084
123MP0002069_abnormal_eating/drinking_beha0.89615863
124MP0004742_abnormal_vestibular_system0.88415607
125MP0005395_other_phenotype0.87624343
126MP0010307_abnormal_tumor_latency0.86552603
127MP0000639_abnormal_adrenal_gland0.83280436
128MP0005535_abnormal_body_temperature0.83268669
129MP0002148_abnormal_hypersensitivity_rea0.83255784
130MP0005448_abnormal_energy_balance0.82720273
131MP0005075_abnormal_melanosome_morpholog0.82681936
132MP0002006_tumorigenesis0.80209089
133MP0004134_abnormal_chest_morphology0.80095865
134MP0000604_amyloidosis0.80036861
135MP0000427_abnormal_hair_cycle0.79928676
136MP0002163_abnormal_gland_morphology0.78328395
137MP0000689_abnormal_spleen_morphology0.77062360
138MP0008469_abnormal_protein_level0.76727379
139MP0001485_abnormal_pinna_reflex0.75574227
140MP0000003_abnormal_adipose_tissue0.75370091
141MP0008004_abnormal_stomach_pH0.75352447
142MP0006292_abnormal_olfactory_placode0.74955963
143MP0004036_abnormal_muscle_relaxation0.74614724
144MP0005165_increased_susceptibility_to0.74265654
145MP0001502_abnormal_circadian_rhythm0.73636320
146MP0002752_abnormal_somatic_nervous0.71391495
147MP0001664_abnormal_digestion0.71110759
148MP0005409_darkened_coat_color0.70573683
149MP0003646_muscle_fatigue0.68982462
150MP0003632_abnormal_nervous_system0.67273639
151MP0005551_abnormal_eye_electrophysiolog0.65743425
152MP0000920_abnormal_myelination0.62788878
153MP0003634_abnormal_glial_cell0.62170725
154MP0006035_abnormal_mitochondrial_morpho0.61925595
155MP0001765_abnormal_ion_homeostasis0.60890334
156MP0004885_abnormal_endolymph0.59494424
157MP0002751_abnormal_autonomic_nervous0.59234252
158MP0000026_abnormal_inner_ear0.58500752
159MP0005620_abnormal_muscle_contractility0.57516609
160MP0001727_abnormal_embryo_implantation0.56490001
161MP0005410_abnormal_fertilization0.56190305
162MP0000631_abnormal_neuroendocrine_gland0.54939160
163MP0000749_muscle_degeneration0.54567311
164MP0001943_abnormal_respiration0.54475369
165MP0006036_abnormal_mitochondrial_physio0.52283358
166MP0008877_abnormal_DNA_methylation0.51724553
167MP0004043_abnormal_pH_regulation0.50300199
168MP0001177_atelectasis0.50207896
169MP0002082_postnatal_lethality0.46548016
170MP0010770_preweaning_lethality0.46548016

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.52225474
2Focal seizures (HP:0007359)6.31418248
3Atonic seizures (HP:0010819)6.12310652
4Epileptic encephalopathy (HP:0200134)5.65492796
5Hypoglycemic seizures (HP:0002173)5.33358642
6Febrile seizures (HP:0002373)5.25686510
7Absence seizures (HP:0002121)5.05107215
8Hyperventilation (HP:0002883)4.96670048
9Dialeptic seizures (HP:0011146)4.94371888
10Myokymia (HP:0002411)4.84613700
11Hyperinsulinemic hypoglycemia (HP:0000825)4.83648006
12Visual hallucinations (HP:0002367)4.80549913
13Hypoglycemic coma (HP:0001325)4.61992310
14Generalized tonic-clonic seizures (HP:0002069)4.40614046
15Ketoacidosis (HP:0001993)4.33873818
16Hyperglycemia (HP:0003074)4.15922321
17Abnormality of endocrine pancreas physiology (HP:0012093)3.56064662
18Abnormality of the pancreatic islet cells (HP:0006476)3.56064662
19Symptomatic seizures (HP:0011145)3.46881116
20Acute necrotizing encephalopathy (HP:0006965)3.46442543
21Broad-based gait (HP:0002136)3.45377302
22Amblyopia (HP:0000646)3.35078788
23Ketosis (HP:0001946)3.33110257
24Progressive cerebellar ataxia (HP:0002073)3.26954538
25Hyperthyroidism (HP:0000836)3.25492780
26Abnormal mitochondria in muscle tissue (HP:0008316)3.23734063
27Gaze-evoked nystagmus (HP:0000640)3.21933549
28Progressive macrocephaly (HP:0004481)3.07256194
29Attenuation of retinal blood vessels (HP:0007843)3.03657256
30Neoplasm of the adrenal cortex (HP:0100641)2.97268763
31Termporal pattern (HP:0011008)2.96961288
32Insidious onset (HP:0003587)2.96961288
33Mitochondrial inheritance (HP:0001427)2.92939620
34Abnormal hair whorl (HP:0010721)2.90771664
35Epileptiform EEG discharges (HP:0011182)2.89406993
36Abnormal rod and cone electroretinograms (HP:0008323)2.86649244
37Lipid accumulation in hepatocytes (HP:0006561)2.86239914
38Poor eye contact (HP:0000817)2.82319535
39Testicular neoplasm (HP:0010788)2.80386925
40Gait imbalance (HP:0002141)2.80187914
41Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.79564495
42Truncal ataxia (HP:0002078)2.76999923
43Pheochromocytoma (HP:0002666)2.76253408
44Cerebral inclusion bodies (HP:0100314)2.75354787
45Thyroiditis (HP:0100646)2.65955693
46Medial flaring of the eyebrow (HP:0010747)2.65792520
47Excessive salivation (HP:0003781)2.65198651
48Drooling (HP:0002307)2.65198651
49Hypothermia (HP:0002045)2.64097452
50Inability to walk (HP:0002540)2.61843900
51Acute encephalopathy (HP:0006846)2.61389223
52Protruding tongue (HP:0010808)2.61140003
53Hematochezia (HP:0002573)2.60875286
54Congenital stationary night blindness (HP:0007642)2.60217301
55Insulin-resistant diabetes mellitus (HP:0000831)2.59615599
56Congenital primary aphakia (HP:0007707)2.58757668
57Impaired social interactions (HP:0000735)2.57367216
58Abnormal social behavior (HP:0012433)2.57367216
59Abnormality of binocular vision (HP:0011514)2.57104112
60Diplopia (HP:0000651)2.57104112
61Neoplasm of the adrenal gland (HP:0100631)2.56014067
62Neuroendocrine neoplasm (HP:0100634)2.55791475
63Panhypogammaglobulinemia (HP:0003139)2.53800057
64EEG with generalized epileptiform discharges (HP:0011198)2.53147283
65Increased hepatocellular lipid droplets (HP:0006565)2.52729311
66Increased CSF lactate (HP:0002490)2.51966979
67Dysmetria (HP:0001310)2.51324295
68Nephrogenic diabetes insipidus (HP:0009806)2.50982286
69Impaired vibration sensation in the lower limbs (HP:0002166)2.50466181
70Absent speech (HP:0001344)2.50198683
71Abnormal eating behavior (HP:0100738)2.49910737
72Dicarboxylic aciduria (HP:0003215)2.49284208
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49284208
743-Methylglutaconic aciduria (HP:0003535)2.48937197
75Scanning speech (HP:0002168)2.46415566
76Late onset (HP:0003584)2.46228086
77Anxiety (HP:0000739)2.46138203
78Hepatocellular necrosis (HP:0001404)2.45703440
79Hydroureter (HP:0000072)2.44887854
80Glycosuria (HP:0003076)2.44857686
81Abnormality of urine glucose concentration (HP:0011016)2.44857686
82Methylmalonic acidemia (HP:0002912)2.43795240
83Dysdiadochokinesis (HP:0002075)2.43468495
84Dysmetric saccades (HP:0000641)2.41317081
85Agitation (HP:0000713)2.36200990
86Abnormality of macular pigmentation (HP:0008002)2.35692671
87Constricted visual fields (HP:0001133)2.34626026
88Generalized myoclonic seizures (HP:0002123)2.33607518
89Hypomagnesemia (HP:0002917)2.33546816
90Abnormal protein glycosylation (HP:0012346)2.33503213
91Abnormal glycosylation (HP:0012345)2.33503213
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.33503213
93Abnormal protein N-linked glycosylation (HP:0012347)2.33503213
94Progressive inability to walk (HP:0002505)2.33147473
95Conjunctival hamartoma (HP:0100780)2.32102151
96Polydipsia (HP:0001959)2.31684751
97Abnormal drinking behavior (HP:0030082)2.31684751
98Sensory axonal neuropathy (HP:0003390)2.30477185
99Retinal dysplasia (HP:0007973)2.29426113
100Nephronophthisis (HP:0000090)2.28863445
101Increased serum pyruvate (HP:0003542)2.28582848
102Abnormality of glycolysis (HP:0004366)2.28582848
103Psychosis (HP:0000709)2.27665148
104Stomatitis (HP:0010280)2.27639999
105Status epilepticus (HP:0002133)2.27426912
106Furrowed tongue (HP:0000221)2.27061771
107Prolonged bleeding time (HP:0003010)2.26190216
108Impaired smooth pursuit (HP:0007772)2.25337885
109Acute lymphatic leukemia (HP:0006721)2.25243347
110Hypsarrhythmia (HP:0002521)2.24830565
111Blue irides (HP:0000635)2.23513544
112Reduced antithrombin III activity (HP:0001976)2.20435148
113Pancreatic fibrosis (HP:0100732)2.19461285
114Abnormality of the heme biosynthetic pathway (HP:0010472)2.17535412
115Degeneration of the lateral corticospinal tracts (HP:0002314)2.17388408
116Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.17388408
117Fair hair (HP:0002286)2.16222529
118Pancreatic cysts (HP:0001737)2.16197824
119Abnormality of vitamin B metabolism (HP:0004340)2.15214675
120Supranuclear gaze palsy (HP:0000605)2.14779023
121Delusions (HP:0000746)2.13691189
122Genital tract atresia (HP:0001827)2.13489693
123Hepatic necrosis (HP:0002605)2.13346346
124Resting tremor (HP:0002322)2.12890558
125Abnormality of the renal cortex (HP:0011035)2.12087698
126Vaginal atresia (HP:0000148)2.11702943
127Abnormality of the corticospinal tract (HP:0002492)2.11256071
128Polyphagia (HP:0002591)2.10180091
129Metaphyseal dysplasia (HP:0100255)2.09337805
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08313703
131Abnormality of alanine metabolism (HP:0010916)2.08313703
132Hyperalaninemia (HP:0003348)2.08313703
133Increased intramyocellular lipid droplets (HP:0012240)2.07705740
134Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06930430
135Action tremor (HP:0002345)2.06476337
136Increased muscle lipid content (HP:0009058)2.06120813
137Optic disc pallor (HP:0000543)2.04562775
138Hemiparesis (HP:0001269)2.02671703
139Petechiae (HP:0000967)2.01951782
140Decreased central vision (HP:0007663)2.01360482
141Prominent metopic ridge (HP:0005487)2.01243520
142Renal Fanconi syndrome (HP:0001994)2.00664984
143Calf muscle hypertrophy (HP:0008981)2.00481946
144Neurofibrillary tangles (HP:0002185)1.99886381
145Specific learning disability (HP:0001328)1.99656131
146Depression (HP:0000716)1.99062153
147Abnormal delayed hypersensitivity skin test (HP:0002963)1.97459746
148Type I transferrin isoform profile (HP:0003642)1.97068620
149Generalized hypopigmentation of hair (HP:0011358)1.97056496
150Urinary bladder sphincter dysfunction (HP:0002839)1.95705497
151Abnormality of salivation (HP:0100755)1.95483107
152Abnormal gallbladder physiology (HP:0012438)1.94322442
153Cholecystitis (HP:0001082)1.94322442
154Poor coordination (HP:0002370)1.93439777
155Incomplete penetrance (HP:0003829)1.92269186
156Poor suck (HP:0002033)1.92139702
157Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91039356
158Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91039356
159Fetal akinesia sequence (HP:0001989)1.90155075
160Abnormality of the renal medulla (HP:0100957)1.88146752
161Narrow nasal bridge (HP:0000446)1.88102730
162Impaired vibratory sensation (HP:0002495)1.87033819
163Impaired pain sensation (HP:0007328)1.86986601
164Abnormality of pain sensation (HP:0010832)1.86986601
165Renal cortical cysts (HP:0000803)1.86400674
166Methylmalonic aciduria (HP:0012120)1.85377065
167Stereotypic behavior (HP:0000733)1.84646557
168Leukodystrophy (HP:0002415)1.84407482
169Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.83881557
170Failure to thrive in infancy (HP:0001531)1.82587843
171Focal dystonia (HP:0004373)1.81987205
172Muscle hypertrophy of the lower extremities (HP:0008968)1.81893796
173X-linked dominant inheritance (HP:0001423)1.81834990
174Abolished electroretinogram (ERG) (HP:0000550)1.80578599
175Increased circulating renin level (HP:0000848)1.77086099
176Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76992651
177Lethargy (HP:0001254)1.76400192
178Polyuria (HP:0000103)1.75031269
179Insulin resistance (HP:0000855)1.72819101
180Thrombocytosis (HP:0001894)1.72056434
181Alveolar cell carcinoma (HP:0006519)1.71816872
182Villous atrophy (HP:0011473)1.71585006
183Abnormality of small intestinal villus morphology (HP:0011472)1.71585006
184Abnormality of B cell number (HP:0010975)1.69026357
185Opisthotonus (HP:0002179)1.68837505
186Cardiomegaly (HP:0001640)1.68577182
187Decreased electroretinogram (ERG) amplitude (HP:0000654)1.67851308

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.05599763
2RIPK45.52396831
3EPHA44.04398147
4CASK4.00904339
5MAP3K123.66136974
6NTRK33.21620602
7MAP3K43.06541278
8MAP2K73.00745365
9TAOK32.81928276
10CDK192.78631124
11BCKDK2.59251115
12BMPR22.49552823
13MAP3K92.49342357
14FGFR22.45045349
15SCYL22.44694874
16TRIM282.41128357
17PLK22.39098428
18NUAK12.38777924
19MAP4K22.36261562
20MKNK12.36068231
21DAPK12.30678596
22ARAF2.29312199
23MINK12.25381395
24KIT2.19020241
25NME12.15551133
26DAPK21.99937355
27MAP2K41.94626401
28ZAK1.94348989
29PINK11.82853069
30TEC1.81361087
31OXSR11.77812039
32GRK51.73481908
33TRPM71.64161595
34MAP2K61.62348548
35NME21.59061159
36TIE11.48891787
37PTK2B1.43116549
38MAPKAPK51.41008355
39KSR11.34670948
40NTRK11.33826417
41FGFR31.33756846
42FLT31.32561477
43MARK11.32478407
44EIF2AK31.30423737
45PRPF4B1.29268830
46PNCK1.28486466
47MAPK131.26405605
48CCNB11.21437925
49PAK61.20673679
50TLK11.17953670
51CAMK2B1.17652016
52CAMK2A1.17298838
53MAP2K31.16913772
54TNIK1.15556296
55PRKCG1.14687176
56PASK1.14370134
57CDK51.11819796
58CAMKK21.11459292
59MAP3K131.10497371
60IKBKE1.09461909
61KSR21.09394637
62BTK1.06209133
63PHKG21.05368308
64PHKG11.05368308
65PDK41.05365978
66PDK31.05365978
67GRK11.04741851
68NTRK21.04649103
69AKT31.04097127
70MAP4K11.00331670
71FGR0.97780147
72SIK30.97178169
73IKBKB0.94538195
74GRK60.93877349
75TSSK60.93531820
76ITK0.91152013
77FES0.90612308
78TBK10.90600249
79RAF10.89837833
80MYLK0.88290834
81CAMKK10.86296589
82INSRR0.85677902
83BRAF0.85631343
84MST40.84397709
85MAP3K50.82936677
86HIPK20.82318966
87PRKCE0.80601330
88PRKG20.79730861
89BCR0.79561985
90SGK2230.78717352
91SGK4940.78717352
92TXK0.78554869
93SGK20.74875324
94RPS6KA50.74125630
95VRK10.70814215
96MAP2K10.70762452
97MAP2K20.69344123
98MAP3K20.68780520
99TAF10.68747129
100DYRK1A0.68255579
101CDK180.67921992
102CSF1R0.67102087
103MAP3K140.65712048
104GRK70.65677040
105CAMK2D0.65452004
106CDK140.65371436
107FER0.64934545
108PIK3CG0.63705628
109CAMK2G0.61701159
110PDK20.60121455
111CDK150.59306391
112BMPR1B0.59152216
113PDK10.58707242
114PRKAA20.58273321
115DAPK30.58138772
116STK38L0.58051164
117STK30.56085695
118ADRBK10.55432894
119MATK0.54965022
120NLK0.54951692
121ROCK20.54563407
122UHMK10.53881510
123MAPK150.53196989
124CSNK1G10.52292377
125SGK10.51516455
126CSNK1G30.50784629
127YES10.50635159
128PDPK10.50618538
129RPS6KB20.49846253
130SIK20.49128002
131CDK11A0.48725295
132JAK30.47054204
133TNK20.46961009
134LYN0.46830737
135WNK40.45809794
136STK380.44517605
137PIM20.44032454
138MAP3K110.43354307
139MKNK20.42668194
140RET0.42445965
141IRAK10.42115680
142MAPK120.41288005
143LCK0.39317153
144ATM0.38356440
145PAK30.38216009
146MAPK70.38144792
147MAP3K10.37656280
148PRKACA0.37617405
149ERBB30.35366819
150ABL10.34808015
151TGFBR10.34419447
152MAP3K60.33301178
153ADRBK20.33276312
154CSNK2A20.32544924
155STK110.31922133
156SYK0.31708938
157PRKCQ0.31404791
158PLK30.31236904
159STK390.31083942
160PRKCA0.29385005
161PRKCB0.28831071
162PRKCH0.27455628
163MAP3K70.26783412
164RPS6KA30.26004518
165CAMK10.25579931
166FYN0.25213887
167PRKCZ0.24940500
168MUSK0.24884497
169CSNK1G20.24056245
170PRKG10.22859606
171PRKD30.22510577
172LATS20.22387266

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.27963144
2Nicotine addiction_Homo sapiens_hsa050334.06694538
3Synaptic vesicle cycle_Homo sapiens_hsa047213.51186774
4Collecting duct acid secretion_Homo sapiens_hsa049663.40463902
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.89134242
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.88724125
7Oxidative phosphorylation_Homo sapiens_hsa001902.77624024
8Long-term potentiation_Homo sapiens_hsa047202.69473583
9Circadian entrainment_Homo sapiens_hsa047132.61337183
10Morphine addiction_Homo sapiens_hsa050322.58890451
11Amphetamine addiction_Homo sapiens_hsa050312.56899964
12GABAergic synapse_Homo sapiens_hsa047272.53656742
13Glutamatergic synapse_Homo sapiens_hsa047242.43047516
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37451766
15Olfactory transduction_Homo sapiens_hsa047402.35774879
16Protein export_Homo sapiens_hsa030602.33079179
17Salivary secretion_Homo sapiens_hsa049702.26401815
18* Taste transduction_Homo sapiens_hsa047422.16718199
19Vibrio cholerae infection_Homo sapiens_hsa051102.12268781
20Dopaminergic synapse_Homo sapiens_hsa047282.07630284
21Alzheimers disease_Homo sapiens_hsa050101.94811651
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89481381
23Peroxisome_Homo sapiens_hsa041461.87715700
24Parkinsons disease_Homo sapiens_hsa050121.85412283
25Propanoate metabolism_Homo sapiens_hsa006401.81181047
26* Serotonergic synapse_Homo sapiens_hsa047261.80908401
27Renin secretion_Homo sapiens_hsa049241.78698462
28Insulin secretion_Homo sapiens_hsa049111.77999671
29Linoleic acid metabolism_Homo sapiens_hsa005911.74210212
30Calcium signaling pathway_Homo sapiens_hsa040201.70122149
31Long-term depression_Homo sapiens_hsa047301.65971800
32Gastric acid secretion_Homo sapiens_hsa049711.60820206
33Tryptophan metabolism_Homo sapiens_hsa003801.53588649
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53063168
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.51817930
36Non-homologous end-joining_Homo sapiens_hsa034501.51473772
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51012593
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50854181
39Selenocompound metabolism_Homo sapiens_hsa004501.44601573
40Oxytocin signaling pathway_Homo sapiens_hsa049211.40101271
41Cholinergic synapse_Homo sapiens_hsa047251.38012040
42Platelet activation_Homo sapiens_hsa046111.32769180
43Cardiac muscle contraction_Homo sapiens_hsa042601.32585025
44Asthma_Homo sapiens_hsa053101.31886790
45Huntingtons disease_Homo sapiens_hsa050161.31607902
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30388387
47One carbon pool by folate_Homo sapiens_hsa006701.30383961
48Arachidonic acid metabolism_Homo sapiens_hsa005901.28615967
49* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28079312
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28050814
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27153158
52Other glycan degradation_Homo sapiens_hsa005111.26986394
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26192818
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23880624
55Gap junction_Homo sapiens_hsa045401.18079190
56Ether lipid metabolism_Homo sapiens_hsa005651.17922704
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16765349
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15573902
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13874975
60GnRH signaling pathway_Homo sapiens_hsa049121.12674636
61Rheumatoid arthritis_Homo sapiens_hsa053231.03352202
62Phototransduction_Homo sapiens_hsa047441.00681640
63* cAMP signaling pathway_Homo sapiens_hsa040241.00551790
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99609016
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98741095
66Cocaine addiction_Homo sapiens_hsa050300.95421831
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95020718
68ABC transporters_Homo sapiens_hsa020100.94980528
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92836238
70Pyruvate metabolism_Homo sapiens_hsa006200.91064633
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.90639052
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90419737
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90295190
74Purine metabolism_Homo sapiens_hsa002300.89343327
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88186785
76Fatty acid metabolism_Homo sapiens_hsa012120.87630023
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87129220
78African trypanosomiasis_Homo sapiens_hsa051430.86760948
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.86197345
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.84947524
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.84346159
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83931181
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82494849
84Estrogen signaling pathway_Homo sapiens_hsa049150.80914194
85Homologous recombination_Homo sapiens_hsa034400.80601235
86Melanogenesis_Homo sapiens_hsa049160.80492827
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79245190
88Axon guidance_Homo sapiens_hsa043600.78616527
89Chemical carcinogenesis_Homo sapiens_hsa052040.78494539
90Pancreatic secretion_Homo sapiens_hsa049720.77654065
91Retinol metabolism_Homo sapiens_hsa008300.76795594
92RNA degradation_Homo sapiens_hsa030180.76079437
93Fatty acid degradation_Homo sapiens_hsa000710.75108150
94Glutathione metabolism_Homo sapiens_hsa004800.75104619
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74698182
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72872904
97Folate biosynthesis_Homo sapiens_hsa007900.68319518
98ErbB signaling pathway_Homo sapiens_hsa040120.65820510
99mTOR signaling pathway_Homo sapiens_hsa041500.65811481
100Glioma_Homo sapiens_hsa052140.64407965
101Basal transcription factors_Homo sapiens_hsa030220.63164637
102Phagosome_Homo sapiens_hsa041450.62895584
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62782369
104Thyroid hormone synthesis_Homo sapiens_hsa049180.62533943
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.62336622
106Metabolic pathways_Homo sapiens_hsa011000.62011902
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61087234
108Allograft rejection_Homo sapiens_hsa053300.60178993
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58230853
110Nitrogen metabolism_Homo sapiens_hsa009100.57408203
111Type II diabetes mellitus_Homo sapiens_hsa049300.56844934
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56189507
113Glucagon signaling pathway_Homo sapiens_hsa049220.55410465
114Oocyte meiosis_Homo sapiens_hsa041140.55327058
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53702499
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49300577
117MAPK signaling pathway_Homo sapiens_hsa040100.47111444
118Autoimmune thyroid disease_Homo sapiens_hsa053200.46926142
119Ras signaling pathway_Homo sapiens_hsa040140.44235730
120VEGF signaling pathway_Homo sapiens_hsa043700.42316017
121Choline metabolism in cancer_Homo sapiens_hsa052310.41681276
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39316633
123Primary immunodeficiency_Homo sapiens_hsa053400.39116946
124N-Glycan biosynthesis_Homo sapiens_hsa005100.38944755
125Fanconi anemia pathway_Homo sapiens_hsa034600.35715352
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35657053
127Graft-versus-host disease_Homo sapiens_hsa053320.35517106
128Sulfur metabolism_Homo sapiens_hsa009200.34386461
129Dilated cardiomyopathy_Homo sapiens_hsa054140.33335308
130Inositol phosphate metabolism_Homo sapiens_hsa005620.32892333
131Hematopoietic cell lineage_Homo sapiens_hsa046400.32273871
132RNA polymerase_Homo sapiens_hsa030200.32228073
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32223733
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.31626141
135Lysosome_Homo sapiens_hsa041420.30696138
136Sulfur relay system_Homo sapiens_hsa041220.30658682
137Type I diabetes mellitus_Homo sapiens_hsa049400.29940271
1382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29626914
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28897444
140Rap1 signaling pathway_Homo sapiens_hsa040150.28565366
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28545914
142Fatty acid elongation_Homo sapiens_hsa000620.27953540
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26874122
144Wnt signaling pathway_Homo sapiens_hsa043100.23597815
145SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22916481
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22523044
147Dorso-ventral axis formation_Homo sapiens_hsa043200.19411293
148Bile secretion_Homo sapiens_hsa049760.19154126
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.19007967
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18799387
151Regulation of autophagy_Homo sapiens_hsa041400.17560701
152Ovarian steroidogenesis_Homo sapiens_hsa049130.16632856
153Butanoate metabolism_Homo sapiens_hsa006500.12594183
154Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.11359151
155Neurotrophin signaling pathway_Homo sapiens_hsa047220.11201995
156Melanoma_Homo sapiens_hsa052180.10919386
157Alcoholism_Homo sapiens_hsa050340.10015446
158Prion diseases_Homo sapiens_hsa050200.09916381
159Circadian rhythm_Homo sapiens_hsa047100.09012242

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