HTR2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratan sulfate catabolic process (GO:0042340)6.06680565
2regulation of sister chromatid cohesion (GO:0007063)5.73603779
3regulation of integrin activation (GO:0033623)5.58904272
4retina vasculature morphogenesis in camera-type eye (GO:0061299)5.41163864
5detection of molecule of bacterial origin (GO:0032490)5.29353647
6cell migration involved in heart development (GO:0060973)4.96584627
7negative regulation of complement activation (GO:0045916)4.93895811
8positive regulation of respiratory burst (GO:0060267)4.91277646
9fibroblast migration (GO:0010761)4.59958233
10auditory behavior (GO:0031223)4.57975372
11cell morphogenesis involved in neuron differentiation (GO:0048667)4.39562742
12definitive hemopoiesis (GO:0060216)4.34515885
13embryonic process involved in female pregnancy (GO:0060136)4.33122247
14macrophage activation involved in immune response (GO:0002281)4.19251595
15regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.18374694
16regulation of protein polyubiquitination (GO:1902914)4.18052961
17regulation of mononuclear cell migration (GO:0071675)4.11922741
18positive regulation of protein homooligomerization (GO:0032464)4.00212746
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.96999866
20positive regulation by organism of defense response of other organism involved in symbiotic interact3.96999866
21modulation by symbiont of host immune response (GO:0052553)3.96999866
22positive regulation by symbiont of host defense response (GO:0052509)3.96999866
23modulation by symbiont of host defense response (GO:0052031)3.96999866
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.96999866
25negative regulation of protein activation cascade (GO:2000258)3.91968332
26positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.85164349
27regulation of extracellular matrix disassembly (GO:0010715)3.83540497
28blood vessel maturation (GO:0001955)3.76914283
29lung lobe morphogenesis (GO:0060463)3.71524911
30platelet dense granule organization (GO:0060155)3.71086837
31ovulation from ovarian follicle (GO:0001542)3.70444214
32leukocyte migration involved in inflammatory response (GO:0002523)3.68179361
33glucocorticoid biosynthetic process (GO:0006704)3.67870301
34regulation of vitamin D biosynthetic process (GO:0060556)3.65170240
35replication fork processing (GO:0031297)3.62729262
36endothelium development (GO:0003158)3.60662586
37negative regulation of endothelial cell apoptotic process (GO:2000352)3.58276917
38positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.58102811
39regulation of podosome assembly (GO:0071801)3.57820241
40pathway-restricted SMAD protein phosphorylation (GO:0060389)3.57719831
41response to pheromone (GO:0019236)3.56854187
42UDP-N-acetylglucosamine metabolic process (GO:0006047)3.56570595
43endothelial cell proliferation (GO:0001935)3.53955038
44negative regulation of nitric oxide biosynthetic process (GO:0045019)3.50484984
45positive regulation of receptor recycling (GO:0001921)3.50290819
46ganglion development (GO:0061548)3.42695786
47negative regulation of systemic arterial blood pressure (GO:0003085)3.37925094
48embryonic skeletal joint morphogenesis (GO:0060272)3.37241749
49regulation of cytokine secretion involved in immune response (GO:0002739)3.34366879
50cellular response to thyroid hormone stimulus (GO:0097067)3.33411824
51positive regulation of steroid hormone secretion (GO:2000833)3.29009571
52artery development (GO:0060840)3.28041617
53chondrocyte proliferation (GO:0035988)3.23995236
54positive regulation of extracellular matrix organization (GO:1903055)3.23632269
55startle response (GO:0001964)3.23567791
56pigment cell differentiation (GO:0050931)3.22030690
57substrate adhesion-dependent cell spreading (GO:0034446)3.20293308
58cellular extravasation (GO:0045123)3.19148992
59positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.18530874
60regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.18530874
61smooth muscle tissue development (GO:0048745)3.16169973
62regulation of macrophage chemotaxis (GO:0010758)3.15113548
63oligosaccharide catabolic process (GO:0009313)3.12297302
64water-soluble vitamin biosynthetic process (GO:0042364)3.10546554
65embryonic placenta development (GO:0001892)3.09140045
66icosanoid transport (GO:0071715)3.07181557
67fatty acid derivative transport (GO:1901571)3.07181557
68natural killer cell mediated cytotoxicity (GO:0042267)3.06718211
69natural killer cell mediated immunity (GO:0002228)3.06718211
70negative regulation of chondrocyte differentiation (GO:0032331)3.06657434
71cellular response to ATP (GO:0071318)3.05381669
72dermatan sulfate biosynthetic process (GO:0030208)3.04663406
73negative regulation of fatty acid biosynthetic process (GO:0045717)3.01818255
74DNA strand renaturation (GO:0000733)3.01219753
75mesenchymal-epithelial cell signaling (GO:0060638)2.99907055
76negative chemotaxis (GO:0050919)2.99639491
77detection of external biotic stimulus (GO:0098581)2.98740444
78gland morphogenesis (GO:0022612)2.97564263
79regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.95962795
80proline biosynthetic process (GO:0006561)2.92882173
81histamine secretion (GO:0001821)2.92335925
82proximal/distal pattern formation (GO:0009954)2.91785952
83negative regulation of humoral immune response (GO:0002921)2.91354482
84neuron remodeling (GO:0016322)2.90354365
85negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.90320481
86positive regulation of p38MAPK cascade (GO:1900745)2.90219455
87protein localization to cell surface (GO:0034394)2.89915935
88regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.89477107
89regulation of germinal center formation (GO:0002634)2.89052338
90regulation of thymocyte apoptotic process (GO:0070243)2.88464963
91positive regulation of calcium ion import (GO:0090280)2.86556739
92regulation of chemokine-mediated signaling pathway (GO:0070099)2.86265383
93membrane lipid catabolic process (GO:0046466)2.85583805
94vitamin catabolic process (GO:0009111)2.85526136
95fat-soluble vitamin catabolic process (GO:0042363)2.85526136
96positive regulation of developmental pigmentation (GO:0048087)2.85470010
97prostate gland growth (GO:0060736)2.84609709
98negative regulation of thymocyte apoptotic process (GO:0070244)2.84298756
99mechanosensory behavior (GO:0007638)2.83542294
100oxidative demethylation (GO:0070989)2.83433707
101bone resorption (GO:0045453)2.81609700
102regulation of establishment or maintenance of cell polarity (GO:0032878)2.80127811
103phospholipid homeostasis (GO:0055091)2.78653103
104sprouting angiogenesis (GO:0002040)2.78454958
105negative regulation of lipid storage (GO:0010888)2.78345361
106regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.77578221
107amine catabolic process (GO:0009310)2.76477064
108cellular biogenic amine catabolic process (GO:0042402)2.76477064
109SMAD protein complex assembly (GO:0007183)2.75910146
110purine nucleotide salvage (GO:0032261)2.75138592
111detection of biotic stimulus (GO:0009595)2.74824024
112negative regulation of mast cell activation (GO:0033004)2.73557764
113platelet-derived growth factor receptor signaling pathway (GO:0048008)2.73127366
114dermatan sulfate metabolic process (GO:0030205)2.72795057
115positive regulation of vasculogenesis (GO:2001214)2.72534185
116positive regulation of actin cytoskeleton reorganization (GO:2000251)2.72023519
117regulation of membrane protein ectodomain proteolysis (GO:0051043)2.71733787
118regulation of vitamin metabolic process (GO:0030656)2.71121236
119antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.71013805
120negative regulation of platelet activation (GO:0010544)2.70932833
121mitotic cell cycle arrest (GO:0071850)2.70318194
122regulation of interferon-beta biosynthetic process (GO:0045357)2.69202874
123endothelial cell morphogenesis (GO:0001886)2.68671413
124positive regulation vascular endothelial growth factor production (GO:0010575)2.68603054
125innervation (GO:0060384)2.68593055
126positive regulation of protein autophosphorylation (GO:0031954)2.66471826
127response to auditory stimulus (GO:0010996)2.65744110
128angiogenesis involved in wound healing (GO:0060055)2.65388732
129macrophage activation (GO:0042116)2.64786729
130positive regulation of fibroblast migration (GO:0010763)2.63911897
131epithelial cell differentiation involved in prostate gland development (GO:0060742)2.63420488
132icosanoid secretion (GO:0032309)2.63142836
133arachidonic acid secretion (GO:0050482)2.63142836
134sphingosine metabolic process (GO:0006670)2.62393169
135glycosphingolipid catabolic process (GO:0046479)2.62380759
136melanocyte differentiation (GO:0030318)2.61697080
137regulation of establishment of cell polarity (GO:2000114)2.60813840
138vasodilation (GO:0042311)2.60093857
139mature B cell differentiation involved in immune response (GO:0002313)2.59448886
140histone H3-K36 demethylation (GO:0070544)2.58226452
141glomerular basement membrane development (GO:0032836)2.58077770
142opsonization (GO:0008228)2.57846783
143sphingoid metabolic process (GO:0046519)2.57029003
144response to thyroid hormone (GO:0097066)2.54946058
145positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.54139598
146natural killer cell activation involved in immune response (GO:0002323)2.52936766
147regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.51057219
148heparin biosynthetic process (GO:0030210)2.50571168
149heparin metabolic process (GO:0030202)2.50571168
150collagen fibril organization (GO:0030199)2.50433813
151negative regulation of nitric-oxide synthase activity (GO:0051001)2.48959975
152keratan sulfate metabolic process (GO:0042339)2.48434466
153phagocytosis, engulfment (GO:0006911)2.48331390
154glycolipid catabolic process (GO:0019377)2.48234568
155regulation of endothelial cell apoptotic process (GO:2000351)2.48095583
156response to inactivity (GO:0014854)2.47811102
157cellular response to ethanol (GO:0071361)2.47585183
158regulation of protein homooligomerization (GO:0032462)2.47180692
159substrate-dependent cell migration (GO:0006929)2.46549675
160mitotic G1 DNA damage checkpoint (GO:0031571)2.45913801
161maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.45142362
162N-acetylneuraminate metabolic process (GO:0006054)2.44261339
163lysosome organization (GO:0007040)2.43716750
164lytic vacuole organization (GO:0080171)2.43716750
165cartilage morphogenesis (GO:0060536)2.43011874
166positive regulation of protein oligomerization (GO:0032461)2.42736982
167positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.41091809
168ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.40519544
169regulation of macrophage cytokine production (GO:0010935)2.40016087
170signal complex assembly (GO:0007172)2.39622635
171positive regulation of leukocyte apoptotic process (GO:2000108)2.39567565
172DNA double-strand break processing (GO:0000729)2.38834903
173COPII vesicle coating (GO:0048208)2.38636705
174basement membrane organization (GO:0071711)2.38549060
175hypotonic response (GO:0006971)2.38135729
176regulation of cellular extravasation (GO:0002691)2.37826758
177negative regulation of anoikis (GO:2000811)2.37584814
178glucocorticoid metabolic process (GO:0008211)2.37459440
179regulation of B cell receptor signaling pathway (GO:0050855)2.36501745
180positive regulation of toll-like receptor signaling pathway (GO:0034123)2.36058900
181heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.34824469
182negative regulation of focal adhesion assembly (GO:0051895)2.32468886
183negative regulation of cell junction assembly (GO:1901889)2.32468886
184negative regulation of adherens junction organization (GO:1903392)2.32468886
185organ formation (GO:0048645)2.32361497
186protein heterotrimerization (GO:0070208)2.32004168
187cranial suture morphogenesis (GO:0060363)2.31848052
188regulation of integrin-mediated signaling pathway (GO:2001044)2.31209854
189neuron projection extension involved in neuron projection guidance (GO:1902284)2.30032471

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.00650976
2IRF8_21731497_ChIP-ChIP_J774_Mouse2.91442491
3GATA1_22025678_ChIP-Seq_K562_Human2.88549091
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66320491
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.63583839
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.59560091
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.56605227
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46488749
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.39586571
10GBX2_23144817_ChIP-Seq_PC3_Human2.29378137
11* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21622237
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.20731127
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.17700090
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15904323
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12494827
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.10566117
17* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07557353
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.07076873
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.03254486
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.03078967
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.03078967
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.03078967
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.02892012
24* GATA2_21666600_ChIP-Seq_HMVEC_Human2.02834771
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.02298316
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.99021107
27AHR_22903824_ChIP-Seq_MCF-7_Human1.98863062
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97620667
29ZNF274_21170338_ChIP-Seq_K562_Hela1.86953403
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84625812
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83979270
32ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.81440593
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.80901641
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.78938221
35* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78927506
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.75863336
37SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.75225413
38* EZH2_27294783_Chip-Seq_NPCs_Mouse1.74588464
39P300_19829295_ChIP-Seq_ESCs_Human1.74001035
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.72710982
41* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72163584
42VDR_24787735_ChIP-Seq_THP-1_Human1.68019883
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.67320225
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.67320225
45CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.67281154
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66409042
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.65281295
48TP53_18474530_ChIP-ChIP_U2OS_Human1.63767633
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62830996
50* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62103669
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60647496
52SALL4_18804426_ChIP-ChIP_XEN_Mouse1.60188052
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59322818
54EWS_26573619_Chip-Seq_HEK293_Human1.58825182
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57252231
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.55021804
57VDR_22108803_ChIP-Seq_LS180_Human1.53473901
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52500444
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50445847
60SMAD4_21799915_ChIP-Seq_A2780_Human1.48814483
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48349471
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.47751653
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46975185
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.46845171
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43233496
66* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43088840
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40837093
68* NFE2_27457419_Chip-Seq_LIVER_Mouse1.40781443
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40554990
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.39006965
71* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38393291
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38289734
73FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37411744
74SOX2_20726797_ChIP-Seq_SW620_Human1.36544293
75CJUN_26792858_Chip-Seq_BT549_Human1.36538583
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34930658
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.34750993
78* CRX_20693478_ChIP-Seq_RETINA_Mouse1.34211190
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31684532
80* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31683879
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31440507
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29986794
83BRD4_25478319_ChIP-Seq_HGPS_Human1.29778076
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29495094
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28804790
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.28715558
87STAT3_23295773_ChIP-Seq_U87_Human1.28476980
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27969616
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27816127
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.26847234
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26585093
92AR_25329375_ChIP-Seq_VCAP_Human1.26051382
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24746951
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24173805
95FUS_26573619_Chip-Seq_HEK293_Human1.22915539
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22369860
97SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.22251050
98* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20268386
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18353743
100CBP_20019798_ChIP-Seq_JUKART_Human1.17797506
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17797506
102MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17446231
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17277299
104* PU_27001747_Chip-Seq_BMDM_Mouse1.15908252
105* E2F1_18555785_Chip-Seq_ESCs_Mouse1.15840540
106TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15585216
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15508343
108POU5F1_16518401_ChIP-PET_MESCs_Mouse1.15355898
109EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13522450
110ER_23166858_ChIP-Seq_MCF-7_Human1.13253182
111SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12859046
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12859046
113TP53_16413492_ChIP-PET_HCT116_Human1.12481713
114TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12244240
115SALL4_22934838_ChIP-ChIP_CD34+_Human1.11683917
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11560863
117BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11052977
118CDX2_22108803_ChIP-Seq_LS180_Human1.10960903
119TFEB_21752829_ChIP-Seq_HELA_Human1.08154780
120KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07214209
121RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06437191
122NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05371303
123SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05249292
124* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04573824
125CDX2_20551321_ChIP-Seq_CACO-2_Human1.04034867
126SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03563934
127TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03116675
128FLI1_21867929_ChIP-Seq_TH2_Mouse1.02610262
129PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01514706
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00797049
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00549312
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00152653
133* CMYC_18555785_Chip-Seq_ESCs_Mouse1.00114966
134* P53_22387025_ChIP-Seq_ESCs_Mouse1.00094137
135EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99926763
136SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99344092
137TCF4_23295773_ChIP-Seq_U87_Human0.98959326
138RXR_22108803_ChIP-Seq_LS180_Human0.96174019
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94356987
140VDR_24763502_ChIP-Seq_THP-1_Human0.93657386
141NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93247883
142* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92425705
143AR_21572438_ChIP-Seq_LNCaP_Human0.91654262
144TCF4_22108803_ChIP-Seq_LS180_Human0.90317499
145SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89775845
146TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88885307
147KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88737250
148ELK3_25401928_ChIP-Seq_HUVEC_Human0.88249338
149P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87984332
150SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87739343
151BCAT_22108803_ChIP-Seq_LS180_Human0.87501799
152VDR_21846776_ChIP-Seq_THP-1_Human0.85103588
153NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.83660734
154JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83084631
155TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82993912
156SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82526248
157TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82011501
158AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81873539
159CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81806049
160* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81759900
161PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78987550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage5.97035013
2MP0000569_abnormal_digit_pigmentation3.46020321
3MP0005275_abnormal_skin_tensile3.42573087
4MP0005171_absent_coat_pigmentation3.34800716
5MP0003172_abnormal_lysosome_physiology3.10472606
6MP0005058_abnormal_lysosome_morphology3.06562244
7MP0008438_abnormal_cutaneous_collagen2.90011580
8MP0001879_abnormal_lymphatic_vessel2.84176114
9MP0009278_abnormal_bone_marrow2.75168044
10MP0005248_abnormal_Harderian_gland2.64026779
11MP0002837_dystrophic_cardiac_calcinosis2.59801277
12MP0001542_abnormal_bone_strength2.52236783
13MP0010234_abnormal_vibrissa_follicle2.46593636
14MP0003279_aneurysm2.44813455
15MP0003724_increased_susceptibility_to2.43733966
16MP0005257_abnormal_intraocular_pressure2.42508040
17MP0005623_abnormal_meninges_morphology2.26674336
18MP0008004_abnormal_stomach_pH2.24896868
19MP0002254_reproductive_system_inflammat2.22437630
20MP0000767_abnormal_smooth_muscle2.11047974
21MP0005174_abnormal_tail_pigmentation2.09306890
22MP0009840_abnormal_foam_cell2.07364438
23MP0001915_intracranial_hemorrhage2.00861355
24MP0002282_abnormal_trachea_morphology1.95731699
25MP0003045_fibrosis1.93246727
26MP0000372_irregular_coat_pigmentation1.91041800
27MP0003303_peritoneal_inflammation1.90310495
28MP0003566_abnormal_cell_adhesion1.70376658
29MP0001958_emphysema1.67024983
30MP0002877_abnormal_melanocyte_morpholog1.59216732
31MP0006138_congestive_heart_failure1.57868124
32MP0009764_decreased_sensitivity_to1.55666319
33MP0005167_abnormal_blood-brain_barrier1.54563534
34MP0000343_altered_response_to1.52076074
35MP0002138_abnormal_hepatobiliary_system1.51471529
36MP0005164_abnormal_response_to1.50003964
37MP0005595_abnormal_vascular_smooth1.49896526
38MP0002295_abnormal_pulmonary_circulatio1.49676058
39* MP0003567_abnormal_fetal_cardiomyocyte1.49457239
40MP0005408_hypopigmentation1.47325157
41MP0003300_gastrointestinal_ulcer1.47291671
42MP0004883_abnormal_blood_vessel1.42512255
43MP0002998_abnormal_bone_remodeling1.41893429
44MP0005397_hematopoietic_system_phenotyp1.41339379
45MP0001545_abnormal_hematopoietic_system1.41339379
46MP0000858_altered_metastatic_potential1.40791893
47MP0010307_abnormal_tumor_latency1.40120686
48MP0003436_decreased_susceptibility_to1.40002097
49MP0002938_white_spotting1.36690809
50MP0000015_abnormal_ear_pigmentation1.35059104
51MP0009697_abnormal_copulation1.34864623
52MP0004084_abnormal_cardiac_muscle1.34597121
53MP0003091_abnormal_cell_migration1.33100600
54MP0003950_abnormal_plasma_membrane1.30791741
55MP0010030_abnormal_orbit_morphology1.30335488
56MP0002108_abnormal_muscle_morphology1.30169711
57MP0003868_abnormal_feces_composition1.28235038
58MP0006082_CNS_inflammation1.27226481
59MP0005670_abnormal_white_adipose1.25010869
60MP0001533_abnormal_skeleton_physiology1.23875100
61MP0004272_abnormal_basement_membrane1.23462933
62MP0003941_abnormal_skin_development1.23254934
63MP0003448_altered_tumor_morphology1.22876378
64MP0005075_abnormal_melanosome_morpholog1.22486228
65MP0005508_abnormal_skeleton_morphology1.22190560
66MP0001851_eye_inflammation1.19815814
67MP0005409_darkened_coat_color1.18965303
68MP0005464_abnormal_platelet_physiology1.17975389
69MP0002419_abnormal_innate_immunity1.15769981
70MP0002139_abnormal_hepatobiliary_system1.14733452
71MP0004130_abnormal_muscle_cell1.13907416
72MP0003136_yellow_coat_color1.13163693
73MP0002060_abnormal_skin_morphology1.11984700
74MP0005503_abnormal_tendon_morphology1.11968532
75MP0002115_abnormal_skeleton_extremities1.11892441
76MP0005076_abnormal_cell_differentiation1.10170829
77MP0003890_abnormal_embryonic-extraembry1.07497564
78MP0004036_abnormal_muscle_relaxation1.07358076
79MP0000604_amyloidosis1.07230892
80MP0003828_pulmonary_edema1.06518121
81MP0001502_abnormal_circadian_rhythm1.06366019
82MP0005390_skeleton_phenotype1.04909918
83MP0002090_abnormal_vision1.04558493
84MP0002095_abnormal_skin_pigmentation1.04399438
85MP0003075_altered_response_to1.03855366
86MP0002168_other_aberrant_phenotype1.01075088
87MP0000490_abnormal_crypts_of1.00739750
88MP0003755_abnormal_palate_morphology1.00543333
89MP0002332_abnormal_exercise_endurance0.99669229
90MP0000249_abnormal_blood_vessel0.99649553
91MP0003195_calcinosis0.98651770
92MP0005646_abnormal_pituitary_gland0.97612147
93MP0000516_abnormal_urinary_system0.97445875
94MP0005367_renal/urinary_system_phenotyp0.97445875
95MP0003935_abnormal_craniofacial_develop0.97318494
96MP0005084_abnormal_gallbladder_morpholo0.96519248
97MP0002933_joint_inflammation0.93317174
98MP0002086_abnormal_extraembryonic_tissu0.92565245
99MP0005187_abnormal_penis_morphology0.92239838
100MP0002113_abnormal_skeleton_development0.89859243
101MP0000163_abnormal_cartilage_morphology0.88486969
102MP0005023_abnormal_wound_healing0.88418505
103MP0003186_abnormal_redox_activity0.87980254
104MP0004858_abnormal_nervous_system0.87125055
105MP0010386_abnormal_urinary_bladder0.86910311
106MP0001849_ear_inflammation0.86143631
107MP0005083_abnormal_biliary_tract0.86049521
108MP0000432_abnormal_head_morphology0.85376178
109MP0001175_abnormal_lung_morphology0.85066425
110MP0001756_abnormal_urination0.85053317
111MP0000465_gastrointestinal_hemorrhage0.84706075
112MP0003453_abnormal_keratinocyte_physiol0.84423042
113MP0004134_abnormal_chest_morphology0.84088866
114* MP0002925_abnormal_cardiovascular_devel0.83637550
115MP0002736_abnormal_nociception_after0.81986063
116MP0003646_muscle_fatigue0.81117451
117MP0010155_abnormal_intestine_physiology0.79275179
118MP0002075_abnormal_coat/hair_pigmentati0.77814764
119MP0008057_abnormal_DNA_replication0.77713274
120MP0003252_abnormal_bile_duct0.77157166
121MP0002109_abnormal_limb_morphology0.76658705
122MP0004510_myositis0.76453730
123MP0002896_abnormal_bone_mineralization0.75302693
124MP0001666_abnormal_nutrient_absorption0.74999689
125MP0010368_abnormal_lymphatic_system0.74921902
126MP0002148_abnormal_hypersensitivity_rea0.73332969
127MP0001614_abnormal_blood_vessel0.73293692
128MP0002405_respiratory_system_inflammati0.72158563
129MP0000639_abnormal_adrenal_gland0.71978597
130MP0004133_heterotaxia0.71539763
131MP0005165_increased_susceptibility_to0.71285052
132MP0000733_abnormal_muscle_development0.71239641
133MP0002116_abnormal_craniofacial_bone0.70077576
134MP0001324_abnormal_eye_pigmentation0.70015491
135MP0005647_abnormal_sex_gland0.68316585
136MP0001661_extended_life_span0.66491380
137MP0003191_abnormal_cellular_cholesterol0.66422114
138MP0003795_abnormal_bone_structure0.66247836
139MP0002128_abnormal_blood_circulation0.65478936
140MP0005379_endocrine/exocrine_gland_phen0.64969618
141MP0004233_abnormal_muscle_weight0.64816802
142MP0010678_abnormal_skin_adnexa0.64701541
143MP0008007_abnormal_cellular_replicative0.64067559
144MP0000371_diluted_coat_color0.63369495
145MP0002166_altered_tumor_susceptibility0.62772910
146MP0002133_abnormal_respiratory_system0.62675456
147MP0005388_respiratory_system_phenotype0.62675456
148MP0003385_abnormal_body_wall0.61901253
149MP0002135_abnormal_kidney_morphology0.59613131
150MP0000538_abnormal_urinary_bladder0.55165009
151MP0002909_abnormal_adrenal_gland0.53049635

Predicted human phenotypes

RankGene SetZ-score
1White forelock (HP:0002211)5.67874941
2Hematochezia (HP:0002573)5.52603074
3Abnormality of glycolipid metabolism (HP:0010969)5.34504336
4Abnormality of liposaccharide metabolism (HP:0010968)5.34504336
5Abnormality of glycosphingolipid metabolism (HP:0004343)5.34504336
6Patchy hypopigmentation of hair (HP:0011365)5.27481584
7Congenital sensorineural hearing impairment (HP:0008527)4.46734037
8Absent frontal sinuses (HP:0002688)4.36016852
9Complement deficiency (HP:0004431)4.14756645
10Spondylolisthesis (HP:0003302)4.13134528
11Glomerulonephritis (HP:0000099)4.09386792
12Nuclear cataract (HP:0100018)3.99465392
13Autoimmune thrombocytopenia (HP:0001973)3.97699146
14Follicular hyperkeratosis (HP:0007502)3.94701641
15Abnormality of the vasculature of the conjunctiva (HP:0008054)3.76813923
16Osteolytic defects of the hand bones (HP:0009699)3.73401340
17Osteolytic defects of the phalanges of the hand (HP:0009771)3.73401340
18Conjunctival telangiectasia (HP:0000524)3.63987833
19Cerebral aneurysm (HP:0004944)3.58481582
20Volvulus (HP:0002580)3.56927936
21Premature rupture of membranes (HP:0001788)3.34414182
22Alopecia of scalp (HP:0002293)3.28975040
23Myocardial infarction (HP:0001658)3.17564247
24Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.14982638
25Mucopolysacchariduria (HP:0008155)3.13199389
26Urinary glycosaminoglycan excretion (HP:0003541)3.13199389
27Abnormality of mucopolysaccharide metabolism (HP:0011020)3.12518254
28Abnormality of polysaccharide metabolism (HP:0011012)3.12518254
29Abnormality of glycosaminoglycan metabolism (HP:0004371)3.12518254
30Increased CSF protein (HP:0002922)3.11660654
31Subacute progressive viral hepatitis (HP:0006572)3.05401625
32Abnormality of the frontal sinuses (HP:0002687)3.05294377
33Ulnar bowing (HP:0003031)3.04025154
34Abnormality of complement system (HP:0005339)3.00841502
35Aortic dissection (HP:0002647)2.98880594
36Hypoplasia of the iris (HP:0007676)2.88246821
37Cervical subluxation (HP:0003308)2.78045926
38Persistence of primary teeth (HP:0006335)2.73079867
39Vascular tortuosity (HP:0004948)2.71149333
40Severe visual impairment (HP:0001141)2.70650059
41Distal lower limb muscle weakness (HP:0009053)2.69292818
42Disinhibition (HP:0000734)2.68079132
43Spontaneous hematomas (HP:0007420)2.67392855
44Muscle fibrillation (HP:0010546)2.66610021
45Tongue fasciculations (HP:0001308)2.65172715
46Turricephaly (HP:0000262)2.64311229
47Cerebral hemorrhage (HP:0001342)2.60743762
48Aqueductal stenosis (HP:0002410)2.58858487
49Dysostosis multiplex (HP:0000943)2.58115556
50Arterial tortuosity (HP:0005116)2.57999038
51Distal lower limb amyotrophy (HP:0008944)2.53183694
52Absent radius (HP:0003974)2.51524776
53Coronal craniosynostosis (HP:0004440)2.47842624
54Increased cerebral lipofuscin (HP:0011813)2.45675036
55Mucosal telangiectasiae (HP:0100579)2.43214695
56Intestinal fistula (HP:0100819)2.42615117
57Cutaneous melanoma (HP:0012056)2.40359729
58Pulmonary artery stenosis (HP:0004415)2.39827963
59Pustule (HP:0200039)2.39083674
60Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.36979434
61Wrist flexion contracture (HP:0001239)2.34161539
62Aplasia involving forearm bones (HP:0009822)2.33794057
63Absent forearm bone (HP:0003953)2.33794057
64Urethral obstruction (HP:0000796)2.32139905
65Bone cyst (HP:0012062)2.30967933
66Systemic lupus erythematosus (HP:0002725)2.30573363
67Cupped ribs (HP:0000887)2.30515590
68Nephritis (HP:0000123)2.23422872
69Hypoplasia of the fovea (HP:0007750)2.22097953
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.22097953
71Zonular cataract (HP:0010920)2.21711544
72Aortic aneurysm (HP:0004942)2.20525173
73Fair hair (HP:0002286)2.19485862
74Colitis (HP:0002583)2.19423684
75Submucous cleft hard palate (HP:0000176)2.16968430
76Generalized hypopigmentation of hair (HP:0011358)2.16875292
77Ankle contracture (HP:0006466)2.15576414
78Blue irides (HP:0000635)2.15042430
79Spinal muscular atrophy (HP:0007269)2.14399493
80Increased neuronal autofluorescent lipopigment (HP:0002074)2.13669795
81Round ear (HP:0100830)2.11939022
82Short nail (HP:0001799)2.10660641
83Aplasia/Hypoplasia of the tibia (HP:0005772)2.09100183
84Loss of speech (HP:0002371)2.08364023
85Abnormal umbilical cord blood vessels (HP:0011403)2.05629782
86Single umbilical artery (HP:0001195)2.05629782
87Abnormality of the fetal cardiovascular system (HP:0010948)2.05629782
88Abnormality of the umbilical cord (HP:0010881)2.05547688
89Rectal fistula (HP:0100590)2.04957919
90Rectovaginal fistula (HP:0000143)2.04957919
91Global brain atrophy (HP:0002283)2.03628545
92Protrusio acetabuli (HP:0003179)2.02075057
93Delayed puberty (HP:0000823)1.99465033
94Tetraparesis (HP:0002273)1.98082235
95Abnormality of proline metabolism (HP:0010907)1.97723021
96Hydroxyprolinuria (HP:0003080)1.97723021
97Abnormality of the nasal septum (HP:0000419)1.97111373
98Keratoconus (HP:0000563)1.95778168
99Increased corneal curvature (HP:0100692)1.95778168
100Recurrent gram-negative bacterial infections (HP:0005420)1.95725661
101Increased connective tissue (HP:0009025)1.95420136
102Generalized hypopigmentation (HP:0007513)1.93842483
103Short tibia (HP:0005736)1.92627027
104Abnormality of the fovea (HP:0000493)1.92028010
105Conjunctival hamartoma (HP:0100780)1.92014628
106Mitral stenosis (HP:0001718)1.91647360
107Rib fusion (HP:0000902)1.90572655
108Recurrent abscess formation (HP:0002722)1.88690069
109Hypoalphalipoproteinemia (HP:0003233)1.88661422
110Heterochromia iridis (HP:0001100)1.88567248
111Hypoplasia of the odontoid process (HP:0003311)1.87441844
112Orchitis (HP:0100796)1.86952882
113Lower limb amyotrophy (HP:0007210)1.86392574
114Portal hypertension (HP:0001409)1.86348485
115Soft skin (HP:0000977)1.85121142
116Cavernous hemangioma (HP:0001048)1.85095952
117Narrow palate (HP:0000189)1.84146612
118Aortic valve stenosis (HP:0001650)1.83430100
119Nonimmune hydrops fetalis (HP:0001790)1.83174775
120Hypochromic microcytic anemia (HP:0004840)1.83098830
121Toxemia of pregnancy (HP:0100603)1.83072391
122Hamartoma of the eye (HP:0010568)1.81374263
123Large earlobe (HP:0009748)1.80959475
124Inappropriate behavior (HP:0000719)1.80828627
125Short humerus (HP:0005792)1.80539673
126Joint stiffness (HP:0001387)1.80160768
127Flared iliac wings (HP:0002869)1.79323447
128Ocular albinism (HP:0001107)1.79241717
129Widely spaced teeth (HP:0000687)1.79004093
130Asymmetric septal hypertrophy (HP:0001670)1.78402289
131Striae distensae (HP:0001065)1.78051168
132Intrahepatic cholestasis (HP:0001406)1.76902488
133Bowing of the arm (HP:0006488)1.76597014
134Bowed forearm bones (HP:0003956)1.76597014
135Mitral valve prolapse (HP:0001634)1.75641003
136Abnormality of the ischium (HP:0003174)1.75212982
137Thyroiditis (HP:0100646)1.74781145
138Vacuolated lymphocytes (HP:0001922)1.74617202
139Abnormality of the fingertips (HP:0001211)1.74396339
140Small hand (HP:0200055)1.74082038
141J-shaped sella turcica (HP:0002680)1.73926444
142Abnormality of macrophages (HP:0004311)1.73551211
143Leiomyosarcoma (HP:0100243)1.73503409
144Uterine leiomyosarcoma (HP:0002891)1.73503409
145Myositis (HP:0100614)1.73208516
146Eczematoid dermatitis (HP:0000976)1.73067661
147Short middle phalanx of the 5th finger (HP:0004220)1.72901362
148Blue sclerae (HP:0000592)1.72374328
149Aplasia/Hypoplasia of the macula (HP:0008059)1.70588929
150Vaginal fistula (HP:0004320)1.70466154
151Hypoplastic ischia (HP:0003175)1.70065914
152Ectropion (HP:0000656)1.70060920
153Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69503144
154Skull defect (HP:0001362)1.69100198
155Fibular hypoplasia (HP:0003038)1.67916909
156Corneal dystrophy (HP:0001131)1.67255998
157Abnormality of B cell number (HP:0010975)1.67161385
158B lymphocytopenia (HP:0010976)1.67161385
159Delayed closure of the anterior fontanelle (HP:0001476)1.65703729
160Gingival overgrowth (HP:0000212)1.65002799
161Tubulointerstitial fibrosis (HP:0005576)1.64799662
162Abnormality of the ileum (HP:0001549)1.63913530
163Arteriovenous malformation (HP:0100026)1.63437956
164Frequent falls (HP:0002359)1.63367928
165Protruding ear (HP:0000411)1.63067914
166Esophageal varix (HP:0002040)1.62670620
167Transitional cell carcinoma of the bladder (HP:0006740)1.61941569
168Aplasia/hypoplasia of the humerus (HP:0006507)1.61650166
169Abnormality of dentin (HP:0010299)1.60744341
170Tubulointerstitial abnormality (HP:0001969)1.60695434
171Albinism (HP:0001022)1.59183847
172Chromosomal breakage induced by crosslinking agents (HP:0003221)1.58407753
173Aplasia cutis congenita (HP:0001057)1.57493237
174Wormian bones (HP:0002645)1.57445168
175Optic neuritis (HP:0100653)1.57199941
176Retrobulbar optic neuritis (HP:0100654)1.57199941

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K64.22847365
2ACVR1B3.60923880
3DDR23.53105592
4FRK3.40532919
5ZAK3.13676628
6GRK13.12131950
7ICK3.00871303
8BMPR1B2.94565016
9PDK22.91721248
10TGFBR22.57489842
11TGFBR12.46254682
12EIF2AK32.39957330
13CDK62.32442127
14TRPM72.32346529
15PAK42.24137748
16NEK12.19431794
17MAP3K112.18669122
18LATS12.16235755
19ERBB32.06316191
20TEC2.01109169
21STK38L1.96457102
22NTRK21.92427615
23FGR1.86627468
24BMX1.83795149
25YES11.78975639
26CDK121.78328769
27CSK1.77700142
28AKT31.76854550
29CSNK1A1L1.65940121
30PDGFRA1.54432071
31ERN11.50240664
32MATK1.49286112
33FER1.47799294
34MAP3K141.43967113
35LATS21.40727101
36PINK11.33225730
37GRK71.32808945
38PTK61.31883405
39WNK31.31822340
40MKNK21.26787940
41PAK31.19706301
42CSNK1G11.18730478
43NEK61.17841151
44CSNK1G31.15919078
45NLK1.13636307
46TNIK1.12728465
47GSK3A1.06793011
48STK31.05112728
49CHUK1.02807009
50BRD40.99634016
51CDK80.97107865
52PIM20.94046855
53PLK20.93088295
54MYLK0.92873339
55TYK20.90030875
56KIT0.89550115
57EGFR0.88078297
58ADRBK20.88053443
59DYRK1B0.88051412
60MKNK10.87526377
61TTN0.87090077
62MAPK150.86981102
63MELK0.86599827
64TRIM280.85947445
65MAPK70.85292854
66STK380.83034560
67CAMK1D0.82889194
68PRPF4B0.82100314
69CSNK1G20.81791025
70NUAK10.81024874
71TXK0.80963003
72CAMKK20.80813253
73IRAK40.80646143
74TYRO30.80038222
75CDC42BPA0.78339506
76MTOR0.77811369
77EIF2AK10.77342401
78MAPK120.75156097
79BCKDK0.69835422
80CDC70.69185620
81ABL20.68683515
82DAPK10.68366488
83BRSK20.67865953
84PDGFRB0.67607046
85MAP3K30.66238324
86PIM10.65299704
87SGK30.65232022
88RPS6KL10.64896960
89RPS6KC10.64896960
90MARK30.64759835
91PRKD20.63394990
92ERBB20.63006220
93MAPK110.61745830
94MAP4K20.60420442
95PTK2B0.60305783
96CDK90.58406456
97TAOK30.58135898
98IKBKB0.57443452
99SIK30.57329410
100ABL10.54752389
101TAF10.54085293
102ATM0.52986816
103TIE10.52666265
104RPS6KA60.51624058
105MAPK100.50866091
106PRKCH0.50860183
107PKN10.49818630
108PLK30.49616163
109JAK10.48754315
110SIK20.48432903
111ERBB40.48408015
112JAK30.47091483
113FES0.46940806
114AKT20.46430038
115DYRK30.44558269
116CDK70.44515930
117NEK90.44003688
118CAMK1G0.43983589
119IKBKE0.42858039
120PRKD10.42451234
121MARK20.41611506
122MAPKAPK50.41030568
123FGFR20.40729848
124EPHA20.39765160
125HCK0.39460055
126SGK20.38601641
127PRKCE0.38042538
128PTK20.37122685
129LCK0.36458365
130SGK10.36306445
131PRKAA10.34885615
132SIK10.34373479
133IRAK30.34223382
134PAK20.33353175
135GRK50.32830795
136BMPR20.32757312
137MAPK10.32570707
138MST40.32412033
139MAP3K120.31814301
140INSRR0.31620631
141TBK10.31149919
142PRKAA20.30945636
143STK240.29673027
144ADRBK10.29278458
145STK390.27094032
146DAPK30.26025955
147IGF1R0.25898230
148MAP2K10.23218556
149MAP2K60.23212308
150PRKD30.22528373
151IRAK10.18954933
152WEE10.15312957
153BLK0.15248762
154EPHA30.14366847
155OXSR10.14256913

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.43162378
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.72216746
3Lysosome_Homo sapiens_hsa041422.46936927
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.29020804
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.13699491
6Adherens junction_Homo sapiens_hsa045201.98772854
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.95388542
8TGF-beta signaling pathway_Homo sapiens_hsa043501.95182358
9Osteoclast differentiation_Homo sapiens_hsa043801.64860554
10Staphylococcus aureus infection_Homo sapiens_hsa051501.63695398
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63163315
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.60528339
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.57351724
14Tryptophan metabolism_Homo sapiens_hsa003801.49505322
15Sulfur metabolism_Homo sapiens_hsa009201.49156484
16Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.46348286
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44648122
18Phagosome_Homo sapiens_hsa041451.41355010
19Base excision repair_Homo sapiens_hsa034101.41214728
20ECM-receptor interaction_Homo sapiens_hsa045121.41142427
21Tuberculosis_Homo sapiens_hsa051521.38233646
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.36757666
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.36657845
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.36487442
25Vitamin B6 metabolism_Homo sapiens_hsa007501.35451912
26Focal adhesion_Homo sapiens_hsa045101.34189022
27Fatty acid biosynthesis_Homo sapiens_hsa000611.32752466
28Proteoglycans in cancer_Homo sapiens_hsa052051.27822605
29Protein export_Homo sapiens_hsa030601.26157599
30Collecting duct acid secretion_Homo sapiens_hsa049661.25649481
31Sphingolipid metabolism_Homo sapiens_hsa006001.21612652
32Fanconi anemia pathway_Homo sapiens_hsa034601.21093023
33Shigellosis_Homo sapiens_hsa051311.20077992
34MicroRNAs in cancer_Homo sapiens_hsa052061.19463317
35Lysine degradation_Homo sapiens_hsa003101.19229193
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.16600968
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16453099
38Malaria_Homo sapiens_hsa051441.15421986
39Rheumatoid arthritis_Homo sapiens_hsa053231.14058582
40Hematopoietic cell lineage_Homo sapiens_hsa046401.12039674
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11794410
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11338692
43mTOR signaling pathway_Homo sapiens_hsa041501.08993523
44ABC transporters_Homo sapiens_hsa020101.08650656
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08567708
46Leishmaniasis_Homo sapiens_hsa051401.07558990
47Apoptosis_Homo sapiens_hsa042101.05692009
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04914861
49Notch signaling pathway_Homo sapiens_hsa043301.04763079
50Prostate cancer_Homo sapiens_hsa052151.04365892
51Hippo signaling pathway_Homo sapiens_hsa043901.02828561
52Pertussis_Homo sapiens_hsa051331.01911434
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.00847489
54PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00738585
55Salmonella infection_Homo sapiens_hsa051320.98627902
56Asthma_Homo sapiens_hsa053100.98573751
57African trypanosomiasis_Homo sapiens_hsa051430.98385339
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98267605
59Small cell lung cancer_Homo sapiens_hsa052220.97372189
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96846244
61B cell receptor signaling pathway_Homo sapiens_hsa046620.95052906
62Vibrio cholerae infection_Homo sapiens_hsa051100.95045984
63Dorso-ventral axis formation_Homo sapiens_hsa043200.95013132
64Propanoate metabolism_Homo sapiens_hsa006400.93857375
65Butanoate metabolism_Homo sapiens_hsa006500.93671817
66Complement and coagulation cascades_Homo sapiens_hsa046100.93360940
67Thyroid cancer_Homo sapiens_hsa052160.89886861
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89491650
69Hepatitis B_Homo sapiens_hsa051610.88384145
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87942687
71Mineral absorption_Homo sapiens_hsa049780.87934167
72Rap1 signaling pathway_Homo sapiens_hsa040150.87131738
73Dilated cardiomyopathy_Homo sapiens_hsa054140.86939738
74Protein digestion and absorption_Homo sapiens_hsa049740.86662695
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86226804
76Viral myocarditis_Homo sapiens_hsa054160.86189686
77Circadian rhythm_Homo sapiens_hsa047100.86184661
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85887179
79Endometrial cancer_Homo sapiens_hsa052130.84081871
80Amoebiasis_Homo sapiens_hsa051460.83961943
81Ovarian steroidogenesis_Homo sapiens_hsa049130.83917729
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83800004
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82469695
84Colorectal cancer_Homo sapiens_hsa052100.80645436
85TNF signaling pathway_Homo sapiens_hsa046680.80196050
86Chronic myeloid leukemia_Homo sapiens_hsa052200.78602042
87Caffeine metabolism_Homo sapiens_hsa002320.77918351
88Basal transcription factors_Homo sapiens_hsa030220.77840415
89Arachidonic acid metabolism_Homo sapiens_hsa005900.77342896
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75430364
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74973920
92Chemical carcinogenesis_Homo sapiens_hsa052040.74105336
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73274808
94Selenocompound metabolism_Homo sapiens_hsa004500.72731286
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.71749958
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70961256
97Measles_Homo sapiens_hsa051620.70959275
98Hepatitis C_Homo sapiens_hsa051600.70849006
99Ras signaling pathway_Homo sapiens_hsa040140.69755620
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67966225
101Tight junction_Homo sapiens_hsa045300.67541712
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.67211917
103VEGF signaling pathway_Homo sapiens_hsa043700.67055648
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66852884
105Glutathione metabolism_Homo sapiens_hsa004800.66108849
106p53 signaling pathway_Homo sapiens_hsa041150.65525085
107Legionellosis_Homo sapiens_hsa051340.65490000
108Influenza A_Homo sapiens_hsa051640.64704453
109Pancreatic cancer_Homo sapiens_hsa052120.63179317
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.61292011
111Primary immunodeficiency_Homo sapiens_hsa053400.61224670
112MAPK signaling pathway_Homo sapiens_hsa040100.60246751
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59999177
114FoxO signaling pathway_Homo sapiens_hsa040680.58354103
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57850976
116Toxoplasmosis_Homo sapiens_hsa051450.57773041
117Viral carcinogenesis_Homo sapiens_hsa052030.57652956
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56000427
119Melanoma_Homo sapiens_hsa052180.55980798
120Choline metabolism in cancer_Homo sapiens_hsa052310.55973195
121Axon guidance_Homo sapiens_hsa043600.55169993
122Basal cell carcinoma_Homo sapiens_hsa052170.54847639
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54312072
124Wnt signaling pathway_Homo sapiens_hsa043100.53649732
125Systemic lupus erythematosus_Homo sapiens_hsa053220.52800022
126Renin-angiotensin system_Homo sapiens_hsa046140.52497749
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52242544
128Non-homologous end-joining_Homo sapiens_hsa034500.51646878
129HIF-1 signaling pathway_Homo sapiens_hsa040660.51636450
130Retinol metabolism_Homo sapiens_hsa008300.50936709
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50765560
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50742564
133Arginine and proline metabolism_Homo sapiens_hsa003300.50639458
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50547636
135Other glycan degradation_Homo sapiens_hsa005110.49942789
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48860962
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44790600
138Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44749070
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44312844
140Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42759605
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42728307
142Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41955825
143Allograft rejection_Homo sapiens_hsa053300.41075806
144N-Glycan biosynthesis_Homo sapiens_hsa005100.39936180
145Peroxisome_Homo sapiens_hsa041460.39651608
146Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36890717
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36586518
148One carbon pool by folate_Homo sapiens_hsa006700.33408444
149Ether lipid metabolism_Homo sapiens_hsa005650.32175197

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