HTR2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)7.76728187
2prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060526.07946553
3lateral sprouting from an epithelium (GO:0060601)5.99574191
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.99295180
5cranial suture morphogenesis (GO:0060363)5.90125140
6otic vesicle formation (GO:0030916)5.65352991
7synaptic vesicle maturation (GO:0016188)5.49252354
8viral transcription (GO:0019083)5.42669477
9locomotory exploration behavior (GO:0035641)5.34896300
10vocalization behavior (GO:0071625)5.31687947
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.26842644
12translational termination (GO:0006415)5.22426496
13synaptic vesicle exocytosis (GO:0016079)5.14614211
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.13256310
15limb bud formation (GO:0060174)5.02449184
16regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.95129751
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.83740472
18regulation of synaptic vesicle exocytosis (GO:2000300)4.81934043
19regulation of glutamate receptor signaling pathway (GO:1900449)4.78287696
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.69856276
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.68145681
22neurotransmitter secretion (GO:0007269)4.64180036
23proline transport (GO:0015824)4.60653902
24midbrain development (GO:0030901)4.56931678
25gamma-aminobutyric acid transport (GO:0015812)4.56354108
26neuronal action potential propagation (GO:0019227)4.55711556
27neuron cell-cell adhesion (GO:0007158)4.53111748
28axon extension involved in axon guidance (GO:0048846)4.51624842
29neuron projection extension involved in neuron projection guidance (GO:1902284)4.51624842
30neuron fate determination (GO:0048664)4.50168546
31regulation of long-term neuronal synaptic plasticity (GO:0048169)4.47953022
32craniofacial suture morphogenesis (GO:0097094)4.47951568
33cotranslational protein targeting to membrane (GO:0006613)4.47438047
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.44448432
35glutamate receptor signaling pathway (GO:0007215)4.44305725
36glutamate secretion (GO:0014047)4.44209054
37presynaptic membrane organization (GO:0097090)4.39358622
38ATP synthesis coupled proton transport (GO:0015986)4.38881904
39energy coupled proton transport, down electrochemical gradient (GO:0015985)4.38881904
40regulation of synaptic vesicle transport (GO:1902803)4.38005304
41somite development (GO:0061053)4.36897293
42protein targeting to ER (GO:0045047)4.33930082
43protein localization to synapse (GO:0035418)4.31971086
44exploration behavior (GO:0035640)4.31131657
45regulation of neuronal synaptic plasticity (GO:0048168)4.29480728
46regulation of non-canonical Wnt signaling pathway (GO:2000050)4.27617867
47mesenchymal cell proliferation (GO:0010463)4.26746619
48layer formation in cerebral cortex (GO:0021819)4.23884184
49prostate gland growth (GO:0060736)4.23132739
50lens fiber cell development (GO:0070307)4.17643110
51establishment of protein localization to endoplasmic reticulum (GO:0072599)4.16632831
52synaptic vesicle docking involved in exocytosis (GO:0016081)4.15366557
53translational elongation (GO:0006414)4.14264152
54lung lobe morphogenesis (GO:0060463)4.13613495
55cellular potassium ion homeostasis (GO:0030007)4.13604084
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.11380275
57regulation of feeding behavior (GO:0060259)4.10105872
58regulation of synapse structural plasticity (GO:0051823)4.09017526
59cellular protein complex disassembly (GO:0043624)4.04551111
60neuron-neuron synaptic transmission (GO:0007270)4.01720229
61synaptic transmission, glutamatergic (GO:0035249)4.01482763
62epithelial cilium movement (GO:0003351)3.99333941
63protein localization to endoplasmic reticulum (GO:0070972)3.96796617
64neurotransmitter transport (GO:0006836)3.95708758
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.95592085
66ribosomal small subunit assembly (GO:0000028)3.94484470
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.90701350
68cilium movement (GO:0003341)3.85684718
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.81581516
70glycine transport (GO:0015816)3.80864823
71neurotransmitter-gated ion channel clustering (GO:0072578)3.80841041
72sodium ion export (GO:0071436)3.78050915
73long-term memory (GO:0007616)3.76389542
74positive regulation of synaptic transmission, GABAergic (GO:0032230)3.75546016
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.75508706
76response to histamine (GO:0034776)3.73376117
77positive regulation of amino acid transport (GO:0051957)3.72600119
78transmission of nerve impulse (GO:0019226)3.72199965
79organ growth (GO:0035265)3.69675299
80gamma-aminobutyric acid signaling pathway (GO:0007214)3.69157007
81neuronal stem cell maintenance (GO:0097150)3.68157339
82regulation of excitatory postsynaptic membrane potential (GO:0060079)3.66934437
83viral life cycle (GO:0019058)3.65020958
84intraciliary transport (GO:0042073)3.64963376
85neuromuscular process controlling posture (GO:0050884)3.64708029
86regulation of synaptic transmission, glutamatergic (GO:0051966)3.62175728
87activation of protein kinase A activity (GO:0034199)3.61149760
88negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.60859299
89regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.60315512
90lung-associated mesenchyme development (GO:0060484)3.58835466
91centriole replication (GO:0007099)3.58636780
92regulation of neurotransmitter levels (GO:0001505)3.57044968
93regulation of postsynaptic membrane potential (GO:0060078)3.56571865
94positive regulation of membrane potential (GO:0045838)3.55938561
95prepulse inhibition (GO:0060134)3.55637169
96epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.52890350
97cartilage morphogenesis (GO:0060536)3.51887665
98retinal ganglion cell axon guidance (GO:0031290)3.51791509
99neuron recognition (GO:0008038)3.51537511
100negative regulation of axon guidance (GO:1902668)3.49874210
101protein complex disassembly (GO:0043241)3.45821341
102response to auditory stimulus (GO:0010996)3.44188985
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.43192095
104regulation of glutamate secretion (GO:0014048)3.41532753
105dendritic spine morphogenesis (GO:0060997)3.40243826
106detection of temperature stimulus (GO:0016048)3.38636467
107positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.38632773
108negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38629944
109regulation of synaptic plasticity (GO:0048167)3.36363346
110positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.35894974
111potassium ion import (GO:0010107)3.34273281
112auditory behavior (GO:0031223)3.32858752
113membrane hyperpolarization (GO:0060081)3.31574419
114mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27033343
115negative regulation of transcription regulatory region DNA binding (GO:2000678)3.26760482
116synaptic vesicle endocytosis (GO:0048488)3.26705722
117regulation of synaptic transmission, GABAergic (GO:0032228)3.26408711
118vesicle transport along microtubule (GO:0047496)3.25989446
119neuromuscular process controlling balance (GO:0050885)3.25612239
120macromolecular complex disassembly (GO:0032984)3.24547249
121regulation of female receptivity (GO:0045924)3.23977038
122regulation of dendritic spine morphogenesis (GO:0061001)3.22483210
123neuronal ion channel clustering (GO:0045161)3.22092535
124striatum development (GO:0021756)3.21794378
125digestive tract morphogenesis (GO:0048546)3.21639308
126regulation of neurotransmitter secretion (GO:0046928)3.21361943
127mating behavior (GO:0007617)3.20858260
128respiratory electron transport chain (GO:0022904)3.20515879
129long-term synaptic potentiation (GO:0060291)3.19919892
130electron transport chain (GO:0022900)3.19190500
131postsynaptic membrane organization (GO:0001941)3.17239696
132nonmotile primary cilium assembly (GO:0035058)3.17179011
133negative regulation of amino acid transport (GO:0051956)3.17076212
134inner mitochondrial membrane organization (GO:0007007)3.16807150
135branching involved in prostate gland morphogenesis (GO:0060442)3.15312139
136L-amino acid import (GO:0043092)3.15306249
137cerebellar Purkinje cell differentiation (GO:0021702)3.14942540
138cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13329341
139negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.12572422
140mechanosensory behavior (GO:0007638)3.12194241
141regulation of vesicle fusion (GO:0031338)3.11699433
142epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.11209155
143translational initiation (GO:0006413)3.11207678
144positive regulation of neurotransmitter transport (GO:0051590)3.10813431
145startle response (GO:0001964)3.09992554
146presynaptic membrane assembly (GO:0097105)3.09020667
147female mating behavior (GO:0060180)3.08285105
148positive regulation of neurotransmitter secretion (GO:0001956)3.07714175
149branching involved in labyrinthine layer morphogenesis (GO:0060670)3.07679955
150short-term memory (GO:0007614)3.05704275
151membrane depolarization (GO:0051899)3.05671521
152regulation of respiratory system process (GO:0044065)3.05443298
153axonal fasciculation (GO:0007413)3.05100433
154learning (GO:0007612)3.03248008
155* behavioral fear response (GO:0001662)3.02252599
156* behavioral defense response (GO:0002209)3.02252599
157regulation of neurotransmitter transport (GO:0051588)3.01352227
158cerebellar Purkinje cell layer development (GO:0021680)3.01245573
159negative regulation of leukocyte chemotaxis (GO:0002689)3.00721762
160regulation of axon guidance (GO:1902667)3.00138232
161G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.98202870
162heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.97514220
163establishment of protein localization to mitochondrial membrane (GO:0090151)2.97388525
164* synaptic transmission (GO:0007268)2.97093206
165adult walking behavior (GO:0007628)2.97063007
166somatic stem cell division (GO:0048103)2.96277896
167membrane depolarization during action potential (GO:0086010)2.95288648
168maturation of SSU-rRNA (GO:0030490)2.91409104
169axonemal dynein complex assembly (GO:0070286)2.91215193
170protein targeting to membrane (GO:0006612)2.89991347
171regulation of chemokine-mediated signaling pathway (GO:0070099)2.89334279
172negative regulation of vascular permeability (GO:0043116)2.85349045
173substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.84735952
174substrate-independent telencephalic tangential migration (GO:0021826)2.84735952
175mesenchymal cell differentiation (GO:0048762)2.83786512
176imidazole-containing compound metabolic process (GO:0052803)2.77075187
177regulation of dopamine metabolic process (GO:0042053)2.74862512
178regulation of catecholamine metabolic process (GO:0042069)2.74862512
179embryonic digestive tract morphogenesis (GO:0048557)2.73746678
180microtubule polymerization or depolymerization (GO:0031109)2.73261568
181radial glial cell differentiation (GO:0060019)2.72803124
182behavioral response to cocaine (GO:0048148)2.72751007
183limb development (GO:0060173)2.72692789
184appendage development (GO:0048736)2.72692789
185convergent extension (GO:0060026)2.72447056
186tongue development (GO:0043586)2.70655409
187regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.68521112
188kinetochore assembly (GO:0051382)2.66616386
189branching involved in salivary gland morphogenesis (GO:0060445)2.66522835
190glomerulus development (GO:0032835)2.66137647
191positive regulation of canonical Wnt signaling pathway (GO:0090263)2.64068690
192dopaminergic neuron differentiation (GO:0071542)2.63589182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.98937125
2GBX2_23144817_ChIP-Seq_PC3_Human3.64199563
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.36006017
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14461878
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12988091
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04507924
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73004754
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73004754
9REST_21632747_ChIP-Seq_MESCs_Mouse2.66750812
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66086836
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.60647957
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59733197
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58448260
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.56622297
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52293826
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.51918344
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51786970
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51594506
19DROSHA_22980978_ChIP-Seq_HELA_Human2.49015390
20* EZH2_27304074_Chip-Seq_ESCs_Mouse2.36964146
21AR_21572438_ChIP-Seq_LNCaP_Human2.32992744
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.30293608
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21567122
24TAF15_26573619_Chip-Seq_HEK293_Human2.20481038
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.17080003
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.16019256
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15885958
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14603832
29EZH2_27294783_Chip-Seq_ESCs_Mouse2.14116831
30* EWS_26573619_Chip-Seq_HEK293_Human2.11776356
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.11560352
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09132397
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.07159880
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93248362
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92977937
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.90221890
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85680203
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77523913
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73964722
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73234293
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.66367257
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.65870581
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65870581
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63678181
45* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56830056
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54418101
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53625127
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52444213
49SOX2_16153702_ChIP-ChIP_HESCs_Human1.49425382
50VDR_22108803_ChIP-Seq_LS180_Human1.48840459
51P300_19829295_ChIP-Seq_ESCs_Human1.43277158
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42353128
53* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41734404
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38200119
55IGF1R_20145208_ChIP-Seq_DFB_Human1.37963808
56* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31976436
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.31661650
58ZNF274_21170338_ChIP-Seq_K562_Hela1.29250748
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.28607165
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.27753159
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.26261276
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26105904
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26105904
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26105904
65LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25951998
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25067665
67* STAT3_23295773_ChIP-Seq_U87_Human1.24527941
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24174289
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23657542
70AR_25329375_ChIP-Seq_VCAP_Human1.23509455
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22925817
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22888799
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22822686
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21513120
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21349231
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20492863
77AR_19668381_ChIP-Seq_PC3_Human1.20366099
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.19829198
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.19328924
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18676207
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18330376
82* TP53_20018659_ChIP-ChIP_R1E_Mouse1.17795285
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16716745
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.16616415
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16430803
86TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15913575
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15344232
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.13778977
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10751099
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10468363
91GABP_17652178_ChIP-ChIP_JURKAT_Human1.09518043
92* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09329652
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09203472
94TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08414054
95AHR_22903824_ChIP-Seq_MCF-7_Human1.08279398
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08154543
97TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07870302
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07713762
99TCF4_23295773_ChIP-Seq_U87_Human1.07686558
100SOX9_26525672_Chip-Seq_HEART_Mouse1.06911272
101TP53_16413492_ChIP-PET_HCT116_Human1.06910361
102GATA1_26923725_Chip-Seq_HPCs_Mouse1.06158861
103ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05856068
104RNF2_27304074_Chip-Seq_NSC_Mouse1.02727725
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02617456
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02568837
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.01919757
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01873504
109NANOG_16153702_ChIP-ChIP_HESCs_Human1.01458854
110POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00363383
111FUS_26573619_Chip-Seq_HEK293_Human1.00086200
112* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99772766
113FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99669996
114* RUNX2_22187159_ChIP-Seq_PCA_Human0.99555233
115* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98151431
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98019179
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97368607
118MYC_18940864_ChIP-ChIP_HL60_Human0.96351380
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96334283
120SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95435295
121ISL1_27105846_Chip-Seq_CPCs_Mouse0.94441356
122NANOG_19829295_ChIP-Seq_ESCs_Human0.94353324
123SOX2_19829295_ChIP-Seq_ESCs_Human0.94353324
124ELK1_19687146_ChIP-ChIP_HELA_Human0.94239912
125EST1_17652178_ChIP-ChIP_JURKAT_Human0.94221233
126PRDM14_20953172_ChIP-Seq_ESCs_Human0.93547512
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93223943
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92352889
129SMAD3_21741376_ChIP-Seq_ESCs_Human0.92079298
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.91576318
131JUN_21703547_ChIP-Seq_K562_Human0.90906203
132EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90892369
133TP53_18474530_ChIP-ChIP_U2OS_Human0.90794691
134TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90084678
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.89839158
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89633583
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89341390
138ER_23166858_ChIP-Seq_MCF-7_Human0.88543940
139BCAT_22108803_ChIP-Seq_LS180_Human0.86956922
140KDM2B_26808549_Chip-Seq_K562_Human0.86527169
141ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86394883

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis7.68805963
2MP0004859_abnormal_synaptic_plasticity6.08102659
3MP0010030_abnormal_orbit_morphology5.63596062
4MP0003880_abnormal_central_pattern5.16875249
5MP0003136_yellow_coat_color4.43079020
6* MP0003635_abnormal_synaptic_transmissio4.23546571
7* MP0009745_abnormal_behavioral_response3.60223113
8* MP0002064_seizures3.52437784
9MP0009379_abnormal_foot_pigmentation3.44829776
10MP0000537_abnormal_urethra_morphology3.43119959
11MP0009046_muscle_twitch3.33983519
12MP0001346_abnormal_lacrimal_gland3.31391128
13* MP0002063_abnormal_learning/memory/cond3.30646207
14MP0002822_catalepsy3.24146365
15MP0004270_analgesia3.22518153
16MP0000579_abnormal_nail_morphology3.19493191
17* MP0002572_abnormal_emotion/affect_behav2.92360936
18MP0002272_abnormal_nervous_system2.84234442
19MP0005423_abnormal_somatic_nervous2.83542827
20MP0001968_abnormal_touch/_nociception2.82866335
21MP0001486_abnormal_startle_reflex2.74443912
22MP0002938_white_spotting2.69021876
23MP0001501_abnormal_sleep_pattern2.59981827
24MP0002734_abnormal_mechanical_nocicepti2.44990779
25MP0003938_abnormal_ear_development2.23855060
26* MP0001440_abnormal_grooming_behavior2.15319044
27MP0002736_abnormal_nociception_after2.04814996
28* MP0002067_abnormal_sensory_capabilities1.99166723
29MP0001970_abnormal_pain_threshold1.97449636
30MP0002733_abnormal_thermal_nociception1.94819866
31MP0002282_abnormal_trachea_morphology1.92669803
32MP0002837_dystrophic_cardiac_calcinosis1.91455333
33MP0003011_delayed_dark_adaptation1.90421166
34MP0009780_abnormal_chondrocyte_physiolo1.87248452
35* MP0008569_lethality_at_weaning1.87134499
36MP0006276_abnormal_autonomic_nervous1.84892283
37MP0004924_abnormal_behavior1.83657507
38MP0005386_behavior/neurological_phenoty1.83657507
39MP0003329_amyloid_beta_deposits1.83504043
40MP0002909_abnormal_adrenal_gland1.83289787
41MP0006292_abnormal_olfactory_placode1.81652125
42MP0005646_abnormal_pituitary_gland1.80579856
43MP0002557_abnormal_social/conspecific_i1.78392547
44MP0002735_abnormal_chemical_nociception1.78207858
45MP0003937_abnormal_limbs/digits/tail_de1.70301503
46MP0001293_anophthalmia1.69222565
47MP0001529_abnormal_vocalization1.68434533
48MP0002184_abnormal_innervation1.66886701
49MP0002653_abnormal_ependyma_morphology1.65217742
50* MP0004142_abnormal_muscle_tone1.63027323
51MP0008789_abnormal_olfactory_epithelium1.60817195
52MP0004133_heterotaxia1.60516143
53MP0004811_abnormal_neuron_physiology1.60101075
54MP0001324_abnormal_eye_pigmentation1.59448483
55MP0000778_abnormal_nervous_system1.56987926
56MP0002249_abnormal_larynx_morphology1.56814095
57MP0003122_maternal_imprinting1.53982837
58MP0002234_abnormal_pharynx_morphology1.52877759
59MP0004885_abnormal_endolymph1.50343347
60MP0005171_absent_coat_pigmentation1.49664761
61MP0000955_abnormal_spinal_cord1.49170709
62MP0003787_abnormal_imprinting1.45319332
63* MP0002066_abnormal_motor_capabilities/c1.45054577
64MP0003633_abnormal_nervous_system1.43233289
65MP0002638_abnormal_pupillary_reflex1.40803417
66MP0003879_abnormal_hair_cell1.40759466
67MP0003690_abnormal_glial_cell1.40560737
68MP0000462_abnormal_digestive_system1.39355746
69MP0002697_abnormal_eye_size1.37972001
70MP0001984_abnormal_olfaction1.36356757
71MP0000383_abnormal_hair_follicle1.35792580
72MP0006072_abnormal_retinal_apoptosis1.35284843
73MP0009250_abnormal_appendicular_skeleto1.34352260
74MP0005645_abnormal_hypothalamus_physiol1.33102296
75MP0002882_abnormal_neuron_morphology1.32174461
76MP0004858_abnormal_nervous_system1.31288283
77MP0000026_abnormal_inner_ear1.30790032
78MP0002233_abnormal_nose_morphology1.29373874
79MP0000762_abnormal_tongue_morphology1.24623067
80* MP0000372_irregular_coat_pigmentation1.24019817
81MP0001286_abnormal_eye_development1.22675912
82MP0002295_abnormal_pulmonary_circulatio1.22606642
83MP0003755_abnormal_palate_morphology1.22145617
84MP0003631_nervous_system_phenotype1.17036640
85MP0000013_abnormal_adipose_tissue1.16555482
86MP0001905_abnormal_dopamine_level1.15907337
87MP0001502_abnormal_circadian_rhythm1.14896137
88MP0003890_abnormal_embryonic-extraembry1.12519520
89MP0001177_atelectasis1.07008761
90MP0005187_abnormal_penis_morphology1.04943645
91MP0010234_abnormal_vibrissa_follicle1.03603585
92MP0008874_decreased_physiological_sensi1.02931674
93MP0005253_abnormal_eye_physiology1.02369534
94MP0008872_abnormal_physiological_respon1.02284946
95MP0002152_abnormal_brain_morphology1.01867994
96MP0005248_abnormal_Harderian_gland1.01133129
97MP0008995_early_reproductive_senescence1.00424964
98MP0003172_abnormal_lysosome_physiology0.99743502
99MP0002229_neurodegeneration0.99449011
100MP0005084_abnormal_gallbladder_morpholo0.98710371
101MP0000049_abnormal_middle_ear0.98101204
102MP0005551_abnormal_eye_electrophysiolog0.97708772
103MP0000920_abnormal_myelination0.96511391
104MP0005391_vision/eye_phenotype0.96197748
105MP0003942_abnormal_urinary_system0.96046666
106MP0000751_myopathy0.95750219
107MP0003283_abnormal_digestive_organ0.95208878
108MP0000534_abnormal_ureter_morphology0.94756777
109MP0003075_altered_response_to0.94637032
110MP0003634_abnormal_glial_cell0.94574514
111MP0005367_renal/urinary_system_phenotyp0.94191799
112MP0000516_abnormal_urinary_system0.94191799
113MP0004085_abnormal_heartbeat0.93643536
114* MP0005535_abnormal_body_temperature0.93467854
115MP0000647_abnormal_sebaceous_gland0.92942946
116MP0002092_abnormal_eye_morphology0.92633359
117MP0002102_abnormal_ear_morphology0.91679811
118MP0000604_amyloidosis0.91134652
119MP0002928_abnormal_bile_duct0.90256444
120* MP0002069_abnormal_eating/drinking_beha0.89858983
121MP0000569_abnormal_digit_pigmentation0.89236435
122MP0005167_abnormal_blood-brain_barrier0.88377170
123MP0005408_hypopigmentation0.86656545
124MP0005195_abnormal_posterior_eye0.84755035
125MP0002876_abnormal_thyroid_physiology0.84294045
126MP0010386_abnormal_urinary_bladder0.83098141
127MP0003119_abnormal_digestive_system0.82571413
128MP0003632_abnormal_nervous_system0.82097257
129MP0001188_hyperpigmentation0.82025612
130MP0004484_altered_response_of0.81464784
131MP0005623_abnormal_meninges_morphology0.81069519
132MP0002090_abnormal_vision0.80604731
133MP0002116_abnormal_craniofacial_bone0.79223902
134MP0005197_abnormal_uvea_morphology0.77856820
135MP0004215_abnormal_myocardial_fiber0.77656932
136MP0003861_abnormal_nervous_system0.77085679
137MP0004742_abnormal_vestibular_system0.76984903
138MP0005394_taste/olfaction_phenotype0.76883403
139MP0005499_abnormal_olfactory_system0.76883403
140MP0004145_abnormal_muscle_electrophysio0.75703467
141MP0003137_abnormal_impulse_conducting0.75325606
142MP0001963_abnormal_hearing_physiology0.72788143
143MP0001299_abnormal_eye_distance/0.71431509
144MP0005409_darkened_coat_color0.70784006
145MP0010678_abnormal_skin_adnexa0.68592214
146MP0003123_paternal_imprinting0.67987739
147MP0004019_abnormal_vitamin_homeostasis0.67650581
148MP0003935_abnormal_craniofacial_develop0.64994695
149MP0002932_abnormal_joint_morphology0.64932498
150MP0002752_abnormal_somatic_nervous0.64862409
151MP0003385_abnormal_body_wall0.64673063
152MP0001664_abnormal_digestion0.63603869
153MP0004233_abnormal_muscle_weight0.62207175
154MP0009703_decreased_birth_body0.60643035
155MP0002109_abnormal_limb_morphology0.60343656
156MP0009697_abnormal_copulation0.60178524
157MP0000631_abnormal_neuroendocrine_gland0.59986125
158MP0003121_genomic_imprinting0.57252369
159MP0001943_abnormal_respiration0.56008586
160MP0004043_abnormal_pH_regulation0.53931496
161MP0004510_myositis0.53859633
162MP0000747_muscle_weakness0.49789343
163MP0001485_abnormal_pinna_reflex0.49459066
164* MP0008961_abnormal_basal_metabolism0.49159006

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.16950339
2Myokymia (HP:0002411)6.51720744
3Focal seizures (HP:0007359)5.91480891
4Visual hallucinations (HP:0002367)5.53303040
5Abnormality of the phalanges of the 2nd finger (HP:0009541)5.12099591
6Papilledema (HP:0001085)4.53251044
7Absence seizures (HP:0002121)4.50671199
8Febrile seizures (HP:0002373)4.47783801
9Atonic seizures (HP:0010819)4.39511078
10Epileptic encephalopathy (HP:0200134)4.38476871
11Generalized tonic-clonic seizures (HP:0002069)4.26750504
12Partial duplication of the phalanx of hand (HP:0009999)4.20158630
13Dialeptic seizures (HP:0011146)4.16092079
14Chronic otitis media (HP:0000389)4.15741471
15Supranuclear gaze palsy (HP:0000605)4.14154565
16Abnormality of the labia minora (HP:0012880)4.07851835
17Abnormality of the parietal bone (HP:0002696)4.05639447
18Partial duplication of thumb phalanx (HP:0009944)3.96616384
19Progressive cerebellar ataxia (HP:0002073)3.93134313
20Action tremor (HP:0002345)3.88838085
21Coronal craniosynostosis (HP:0004440)3.88744930
22Stenosis of the external auditory canal (HP:0000402)3.83145435
23Dysdiadochokinesis (HP:0002075)3.64913498
24Depression (HP:0000716)3.64530302
25Turricephaly (HP:0000262)3.58112123
26Abnormal ciliary motility (HP:0012262)3.53652944
27Esophageal atresia (HP:0002032)3.51396011
28Broad-based gait (HP:0002136)3.50070900
29Mutism (HP:0002300)3.48824214
30Abnormality of the middle phalanges of the toes (HP:0010183)3.48174041
31Postural instability (HP:0002172)3.48099721
32Abnormality of binocular vision (HP:0011514)3.47833508
33Diplopia (HP:0000651)3.47833508
34Ankle clonus (HP:0011448)3.41286472
35Anxiety (HP:0000739)3.40312609
36Broad metatarsal (HP:0001783)3.34669494
37Pancreatic fibrosis (HP:0100732)3.28194464
38Abnormal respiratory motile cilium physiology (HP:0012261)3.26239114
39Dysmetria (HP:0001310)3.24640470
40Abnormality of incisor morphology (HP:0011063)3.23730675
41Abnormal eating behavior (HP:0100738)3.23009323
42Split foot (HP:0001839)3.22010795
43Progressive inability to walk (HP:0002505)3.16916370
44Humeroradial synostosis (HP:0003041)3.16851633
45Synostosis involving the elbow (HP:0003938)3.16851633
46Impaired vibration sensation in the lower limbs (HP:0002166)3.15755625
47Ventricular fibrillation (HP:0001663)3.14049005
48Abnormal respiratory epithelium morphology (HP:0012253)3.08854142
49Abnormal respiratory motile cilium morphology (HP:0005938)3.08854142
50Neurofibrillary tangles (HP:0002185)3.05922892
51Truncal ataxia (HP:0002078)3.03288344
52Gaze-evoked nystagmus (HP:0000640)3.03259021
53Broad distal phalanx of finger (HP:0009836)3.01692115
54Absent septum pellucidum (HP:0001331)3.01541739
55Rhinitis (HP:0012384)2.99556577
56Hemiparesis (HP:0001269)2.98430640
57Abnormal number of erythroid precursors (HP:0012131)2.93956579
58Poor eye contact (HP:0000817)2.93159679
59Abnormality of the 2nd finger (HP:0004100)2.91547129
60Urinary bladder sphincter dysfunction (HP:0002839)2.91267621
61Cerebral inclusion bodies (HP:0100314)2.87645883
62Hyperventilation (HP:0002883)2.86752139
63Impaired social interactions (HP:0000735)2.84977402
64Abnormal social behavior (HP:0012433)2.84977402
65Concave nail (HP:0001598)2.83822423
66Urinary urgency (HP:0000012)2.83321544
67Nephronophthisis (HP:0000090)2.83302550
68Abdominal situs inversus (HP:0003363)2.82947546
69Abnormality of abdominal situs (HP:0011620)2.82947546
70True hermaphroditism (HP:0010459)2.82224906
71Abnormality of cells of the erythroid lineage (HP:0012130)2.82053439
72Buphthalmos (HP:0000557)2.77766382
73Trigonocephaly (HP:0000243)2.77660746
74Bell-shaped thorax (HP:0001591)2.76571134
75Scanning speech (HP:0002168)2.75320468
76Torticollis (HP:0000473)2.74919760
77Stomach cancer (HP:0012126)2.74755287
78Intention tremor (HP:0002080)2.74272856
79Vaginal atresia (HP:0000148)2.73666094
80Neuronal loss in central nervous system (HP:0002529)2.71461370
81Bradykinesia (HP:0002067)2.70708627
82Molar tooth sign on MRI (HP:0002419)2.70259883
83Abnormality of midbrain morphology (HP:0002418)2.70259883
84Pancreatic cysts (HP:0001737)2.70083143
85Intellectual disability, moderate (HP:0002342)2.69067852
86Cutaneous finger syndactyly (HP:0010554)2.68808381
87Genital tract atresia (HP:0001827)2.67251432
88Polyphagia (HP:0002591)2.62418948
89Status epilepticus (HP:0002133)2.61975372
90Septo-optic dysplasia (HP:0100842)2.60866792
91Hemiplegia (HP:0002301)2.58331162
92Spastic gait (HP:0002064)2.57544276
93Amblyopia (HP:0000646)2.55962905
94Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.53431466
95Overriding aorta (HP:0002623)2.52601342
96Bronchomalacia (HP:0002780)2.52254346
97Excessive salivation (HP:0003781)2.49343337
98Drooling (HP:0002307)2.49343337
99Ulnar bowing (HP:0003031)2.48402581
100Focal dystonia (HP:0004373)2.43591819
101Abnormality of the septum pellucidum (HP:0007375)2.43074433
102Fetal akinesia sequence (HP:0001989)2.41018326
103Alacrima (HP:0000522)2.40448008
104Genetic anticipation (HP:0003743)2.39209056
105Anencephaly (HP:0002323)2.32880618
106Pheochromocytoma (HP:0002666)2.32540051
107Long nose (HP:0003189)2.30763855
108Resting tremor (HP:0002322)2.29298505
109Abnormality of permanent molar morphology (HP:0011071)2.28021585
110Abnormality of the dental root (HP:0006486)2.28021585
111Taurodontia (HP:0000679)2.28021585
112Craniofacial dystonia (HP:0012179)2.27914549
113Reticulocytopenia (HP:0001896)2.26616586
114Impaired smooth pursuit (HP:0007772)2.26523739
115Gastrointestinal atresia (HP:0002589)2.25977457
116Thickened helices (HP:0000391)2.25857666
117Amyotrophic lateral sclerosis (HP:0007354)2.23098369
118Cutaneous syndactyly (HP:0012725)2.21470006
119Termporal pattern (HP:0011008)2.21102155
120Insidious onset (HP:0003587)2.21102155
121Duplication of thumb phalanx (HP:0009942)2.20836677
122Obstructive sleep apnea (HP:0002870)2.18976597
123Medial flaring of the eyebrow (HP:0010747)2.18734160
124Abnormality of the lower motor neuron (HP:0002366)2.18506487
125Gait imbalance (HP:0002141)2.15127554
126Prolonged QT interval (HP:0001657)2.15068627
127Keratoconus (HP:0000563)2.15066399
128Increased corneal curvature (HP:0100692)2.15066399
129Aqueductal stenosis (HP:0002410)2.14991298
130Abnormality of the corticospinal tract (HP:0002492)2.14143668
131Generalized myoclonic seizures (HP:0002123)2.13475748
132Peripheral hypomyelination (HP:0007182)2.13275440
133Psychosis (HP:0000709)2.09552132
134Sleep apnea (HP:0010535)2.09311932
135Dysmetric saccades (HP:0000641)2.08237371
136Absent speech (HP:0001344)2.07817020
137Sclerocornea (HP:0000647)2.07496789
138Lower limb muscle weakness (HP:0007340)2.07196375
139Abnormal EKG (HP:0003115)2.07010764
140Abnormality of molar (HP:0011077)2.06809914
141Abnormality of molar morphology (HP:0011070)2.06809914
142Stereotypic behavior (HP:0000733)2.05280147
143Macrocytic anemia (HP:0001972)2.04628869
144Limb dystonia (HP:0002451)2.04428442
145Abnormality of ocular smooth pursuit (HP:0000617)2.04311752
146Abnormality of the renal medulla (HP:0100957)2.03627185
147Aplasia/Hypoplasia of the tongue (HP:0010295)2.03500512
148Gait ataxia (HP:0002066)2.03444408
149Short hallux (HP:0010109)2.01648992
150Annular pancreas (HP:0001734)2.01198510
151Shallow orbits (HP:0000586)2.00688801
152Blue irides (HP:0000635)2.00445644
153Cystic liver disease (HP:0006706)1.99943237
154Impaired vibratory sensation (HP:0002495)1.99191835
155Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.98604806
156Abnormality of the dental pulp (HP:0006479)1.98555515
157Agitation (HP:0000713)1.98263749
158Megalencephaly (HP:0001355)1.97281124
159Decreased lacrimation (HP:0000633)1.97169919
160Congenital primary aphakia (HP:0007707)1.97033844
161Dynein arm defect of respiratory motile cilia (HP:0012255)1.96764144
162Absent/shortened dynein arms (HP:0200106)1.96764144
163Increased hepatocellular lipid droplets (HP:0006565)1.96757075
164Epileptiform EEG discharges (HP:0011182)1.95840253
165Decreased central vision (HP:0007663)1.95530882
166Abnormality of the distal phalanx of the thumb (HP:0009617)1.95373508
167Neuroendocrine neoplasm (HP:0100634)1.95155849
168Inability to walk (HP:0002540)1.94571112
169Rapidly progressive (HP:0003678)1.94515260
170Failure to thrive in infancy (HP:0001531)1.94242527
171Aplasia/Hypoplasia of the hallux (HP:0008362)1.94000491
172Rigidity (HP:0002063)1.93710285
173Congenital glaucoma (HP:0001087)1.93429337
174Lipid accumulation in hepatocytes (HP:0006561)1.93172139
175EEG with generalized epileptiform discharges (HP:0011198)1.92590634
176Occipital encephalocele (HP:0002085)1.91742509
177Limited elbow extension (HP:0001377)1.91143512
178Preaxial hand polydactyly (HP:0001177)1.91089296
179Clonus (HP:0002169)1.90902743
180Nephrogenic diabetes insipidus (HP:0009806)1.90309384
181Abnormality of saccadic eye movements (HP:0000570)1.88653224
182Aplasia involving bones of the upper limbs (HP:0009823)1.88048338
183Aplasia of the phalanges of the hand (HP:0009802)1.88048338
184Aplasia involving bones of the extremities (HP:0009825)1.88048338
185Incomplete penetrance (HP:0003829)1.86876336
186Short tibia (HP:0005736)1.85273620
187Nasolacrimal duct obstruction (HP:0000579)1.84455346
188Abnormality of the nasolacrimal system (HP:0000614)1.84394771
189Ankyloglossia (HP:0010296)1.83992489
190Insomnia (HP:0100785)1.80921592
191Delusions (HP:0000746)1.79292522

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR27.67710608
2MAP3K95.06757740
3NTRK34.25729324
4EPHA43.83482127
5MAP3K43.14120947
6BUB13.01744251
7RIPK42.71180870
8EPHB22.61211116
9STK242.57134266
10ARAF2.56342157
11MINK12.49119012
12MAP2K72.48701133
13KSR22.41741579
14MARK12.38734913
15MAP3K132.33901834
16MAP3K122.24544430
17MAPK152.22644826
18NTRK22.21919344
19EPHA32.17315771
20PASK2.11252105
21STK38L2.10385905
22MAP2K42.03036061
23PNCK1.97788712
24DYRK31.88996146
25NTRK11.80648421
26SIK21.78916974
27CAMKK11.75006546
28PAK61.69048256
29CASK1.68144689
30TNIK1.63258521
31DAPK21.61735523
32KSR11.61244417
33FGFR11.59479311
34PRKD31.56545087
35FES1.53475718
36WEE11.44514691
37CDK51.42599854
38LATS21.35661103
39RPS6KA41.35621704
40GRK51.32537002
41STK381.32265909
42NEK21.25911764
43RAF11.25361214
44STK31.23505694
45PKN11.19254042
46ZAK1.19127051
47TGFBR11.17485420
48CAMKK21.16008560
49TLK11.12293479
50PLK21.12042477
51PRKCG1.10973380
52MAP3K21.10430933
53DYRK21.09226267
54MAPK131.05923186
55TYRO31.05589814
56BRSK21.04883383
57DAPK11.03032902
58UHMK11.02815241
59INSRR1.02750259
60NUAK11.02400895
61CAMK2A1.02191941
62CDK80.98888582
63CDK190.97367770
64BMPR20.96379397
65PINK10.94126366
66DDR20.93862499
67BCKDK0.91243090
68MAP3K110.90875108
69SGK4940.90113475
70SGK2230.90113475
71PHKG20.89013914
72PHKG10.89013914
73PLK30.86681289
74PRKCH0.86241555
75STK110.84731765
76LATS10.84026725
77VRK10.83558140
78CAMK2B0.82862619
79TNK20.80592330
80CDK30.80537730
81CDK180.79377478
82CAMK10.79259608
83CDK150.79199398
84MAP3K10.77882468
85RET0.77778746
86CDK140.77680977
87BMPR1B0.77343748
88SGK20.76002822
89LMTK20.75881302
90MAP4K20.73617191
91MOS0.73191488
92IRAK20.71037592
93OXSR10.70951368
94SGK30.69340335
95SGK10.69201011
96CSNK1G20.69006051
97ALK0.68902173
98CDK11A0.66713479
99PDK10.65554215
100BRAF0.61604279
101MAP3K60.60934503
102WNK10.60055622
103CAMK1G0.59930213
104TTK0.59743463
105PDPK10.59119432
106CAMK2G0.59029101
107SRPK10.57371592
108FGR0.56146894
109CAMK2D0.55767264
110PRPF4B0.55177410
111CCNB10.55149496
112PRKCE0.55105637
113MAP3K100.54982667
114NEK60.53638708
115PAK30.51566387
116STK390.49361872
117NEK10.49128650
118AURKB0.48775197
119MAPK100.48218887
120ROCK20.47495941
121PTK2B0.46597572
122* RPS6KA30.46454833
123GRK70.46110477
124FYN0.46022222
125SCYL20.45764771
126MAPK70.45085119
127PRKCZ0.44787423
128WNK30.44771266
129PRKG10.44561136
130PLK40.43846568
131TAOK10.43123876
132MAP3K50.43018358
133CDC42BPA0.42778198
134BRSK10.42718785
135TRIM280.42660864
136DYRK1A0.42458287
137NME10.41467876
138PIK3CA0.41138110
139MARK20.40884282
140ADRBK10.40289189
141PLK10.39751492
142MAP2K10.38521160
143NLK0.37924878
144DMPK0.36854658
145MKNK10.34421469
146PRKCB0.33923381
147FER0.32618294
148PRKCQ0.32514044
149CHEK20.30842608
150PRKACA0.30790204
151ERBB30.29821317
152LRRK20.29369487
153ADRBK20.29089683
154BCR0.28961768
155OBSCN0.28357592
156RPS6KA50.27570984
157DYRK1B0.27043532
158VRK20.25366992
159AURKA0.22316094

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.86666488
2Nicotine addiction_Homo sapiens_hsa050333.97505771
3Synaptic vesicle cycle_Homo sapiens_hsa047213.29516832
4Huntingtons disease_Homo sapiens_hsa050162.99179120
5GABAergic synapse_Homo sapiens_hsa047272.97069137
6Olfactory transduction_Homo sapiens_hsa047402.73706587
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70127604
8Morphine addiction_Homo sapiens_hsa050322.69429758
9Glutamatergic synapse_Homo sapiens_hsa047242.52519004
10Circadian entrainment_Homo sapiens_hsa047132.50802053
11Long-term potentiation_Homo sapiens_hsa047202.50499531
12Basal cell carcinoma_Homo sapiens_hsa052172.49034172
13Amphetamine addiction_Homo sapiens_hsa050312.29974772
14Hedgehog signaling pathway_Homo sapiens_hsa043402.23156621
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22273014
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.21412192
17Salivary secretion_Homo sapiens_hsa049702.12923815
18Dopaminergic synapse_Homo sapiens_hsa047282.00326665
19Protein export_Homo sapiens_hsa030601.94182169
20Gastric acid secretion_Homo sapiens_hsa049711.92868477
21Insulin secretion_Homo sapiens_hsa049111.85669531
22Nitrogen metabolism_Homo sapiens_hsa009101.81430885
23Renin secretion_Homo sapiens_hsa049241.80854398
24Collecting duct acid secretion_Homo sapiens_hsa049661.78166734
25Cholinergic synapse_Homo sapiens_hsa047251.76761807
26Cocaine addiction_Homo sapiens_hsa050301.76214073
27Taste transduction_Homo sapiens_hsa047421.71622616
28Long-term depression_Homo sapiens_hsa047301.64895869
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61542509
30TGF-beta signaling pathway_Homo sapiens_hsa043501.61239401
31* Serotonergic synapse_Homo sapiens_hsa047261.60894617
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.60444361
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55803291
34Oxytocin signaling pathway_Homo sapiens_hsa049211.54396182
35* Calcium signaling pathway_Homo sapiens_hsa040201.52126639
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51492690
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50089356
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43839034
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.38540237
40GnRH signaling pathway_Homo sapiens_hsa049121.36279298
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31719286
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31050059
43* Gap junction_Homo sapiens_hsa045401.30287105
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27801991
45Hippo signaling pathway_Homo sapiens_hsa043901.27322674
46cAMP signaling pathway_Homo sapiens_hsa040241.25103013
47* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18985375
48* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17395553
49Cardiac muscle contraction_Homo sapiens_hsa042601.17184991
50Wnt signaling pathway_Homo sapiens_hsa043101.09091504
51RNA polymerase_Homo sapiens_hsa030201.08616306
52Vibrio cholerae infection_Homo sapiens_hsa051101.08079875
53Vitamin digestion and absorption_Homo sapiens_hsa049771.06867292
54Estrogen signaling pathway_Homo sapiens_hsa049151.06177833
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04143928
56Basal transcription factors_Homo sapiens_hsa030221.02149940
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99752701
58Type II diabetes mellitus_Homo sapiens_hsa049300.98478991
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95783745
60Glioma_Homo sapiens_hsa052140.94949488
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94454815
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.92968477
63ErbB signaling pathway_Homo sapiens_hsa040120.91922755
64Dorso-ventral axis formation_Homo sapiens_hsa043200.91840794
65Fanconi anemia pathway_Homo sapiens_hsa034600.89230276
66Pancreatic secretion_Homo sapiens_hsa049720.88224976
67Proteasome_Homo sapiens_hsa030500.87752644
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87098975
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86749856
70Melanogenesis_Homo sapiens_hsa049160.86595100
71Axon guidance_Homo sapiens_hsa043600.85216413
72Thyroid hormone synthesis_Homo sapiens_hsa049180.81846745
73Linoleic acid metabolism_Homo sapiens_hsa005910.81798608
74RNA degradation_Homo sapiens_hsa030180.81398346
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.80343624
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.79420909
77Folate biosynthesis_Homo sapiens_hsa007900.79413386
78Dilated cardiomyopathy_Homo sapiens_hsa054140.78516144
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78495408
80Type I diabetes mellitus_Homo sapiens_hsa049400.77822146
81Protein digestion and absorption_Homo sapiens_hsa049740.77135369
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76214443
83Bile secretion_Homo sapiens_hsa049760.74524278
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71955624
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.70828979
86Oocyte meiosis_Homo sapiens_hsa041140.70300646
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69984643
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66418180
89Homologous recombination_Homo sapiens_hsa034400.65461979
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65269015
91Prion diseases_Homo sapiens_hsa050200.63469018
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62820637
93Chemical carcinogenesis_Homo sapiens_hsa052040.61921751
94MAPK signaling pathway_Homo sapiens_hsa040100.61829078
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60061565
96Choline metabolism in cancer_Homo sapiens_hsa052310.58220509
97Circadian rhythm_Homo sapiens_hsa047100.56460629
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56023784
99Phototransduction_Homo sapiens_hsa047440.54050705
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52662958
101Mineral absorption_Homo sapiens_hsa049780.52311987
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51886554
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51786804
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.51155219
105Selenocompound metabolism_Homo sapiens_hsa004500.50973326
106ABC transporters_Homo sapiens_hsa020100.50479560
107Purine metabolism_Homo sapiens_hsa002300.50299817
108Nucleotide excision repair_Homo sapiens_hsa034200.48886718
109Alzheimers disease_Homo sapiens_hsa050100.47144233
110Rap1 signaling pathway_Homo sapiens_hsa040150.47012354
111Notch signaling pathway_Homo sapiens_hsa043300.46027245
112Ras signaling pathway_Homo sapiens_hsa040140.45891194
113Butanoate metabolism_Homo sapiens_hsa006500.45496484
114Metabolic pathways_Homo sapiens_hsa011000.45019054
115Fatty acid elongation_Homo sapiens_hsa000620.44252206
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44114466
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43731574
118VEGF signaling pathway_Homo sapiens_hsa043700.43517470
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43061084
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42700469
121Spliceosome_Homo sapiens_hsa030400.42364176
122Glucagon signaling pathway_Homo sapiens_hsa049220.42242993
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.42205885
124Alcoholism_Homo sapiens_hsa050340.40937865
125Glutathione metabolism_Homo sapiens_hsa004800.40439566
126Ovarian steroidogenesis_Homo sapiens_hsa049130.40436109
127Inositol phosphate metabolism_Homo sapiens_hsa005620.39868173
128Caffeine metabolism_Homo sapiens_hsa002320.38631791
129Arachidonic acid metabolism_Homo sapiens_hsa005900.38055616
130Endocytosis_Homo sapiens_hsa041440.38010324
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37837038
132Retinol metabolism_Homo sapiens_hsa008300.37571503
133Propanoate metabolism_Homo sapiens_hsa006400.37215399
134Oxidative phosphorylation_Homo sapiens_hsa001900.36628545
135Sulfur metabolism_Homo sapiens_hsa009200.35941499
136Arginine biosynthesis_Homo sapiens_hsa002200.35926935
137Steroid biosynthesis_Homo sapiens_hsa001000.35355877
138African trypanosomiasis_Homo sapiens_hsa051430.35268514
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.34251034
140Non-small cell lung cancer_Homo sapiens_hsa052230.34175597
141Rheumatoid arthritis_Homo sapiens_hsa053230.33560033
142Pathways in cancer_Homo sapiens_hsa052000.32805457
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32110545
144Cysteine and methionine metabolism_Homo sapiens_hsa002700.31445823
145mTOR signaling pathway_Homo sapiens_hsa041500.30508646
146Renal cell carcinoma_Homo sapiens_hsa052110.29266731
147Ether lipid metabolism_Homo sapiens_hsa005650.29098240
148Chemokine signaling pathway_Homo sapiens_hsa040620.28675657
149Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28143539
150Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26664431
151Parkinsons disease_Homo sapiens_hsa050120.26655224
152mRNA surveillance pathway_Homo sapiens_hsa030150.26378849
153Cell cycle_Homo sapiens_hsa041100.26340306
154Insulin signaling pathway_Homo sapiens_hsa049100.26088846
155Tryptophan metabolism_Homo sapiens_hsa003800.25904622
156ECM-receptor interaction_Homo sapiens_hsa045120.25408614
157Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24749910

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