HTR3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1startle response (GO:0001964)7.13247417
2maternal behavior (GO:0042711)6.32657090
3parental behavior (GO:0060746)5.84324129
4vocalization behavior (GO:0071625)5.74429099
5positive regulation of synapse maturation (GO:0090129)5.72979924
6regulation of synapse maturation (GO:0090128)5.70983539
7pyrimidine nucleobase catabolic process (GO:0006208)5.51236598
8neuron cell-cell adhesion (GO:0007158)5.37465551
9negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 5.20640872
10positive regulation of amino acid transport (GO:0051957)5.06528335
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.04379645
12cell migration in hindbrain (GO:0021535)5.03539089
13limb bud formation (GO:0060174)5.03376988
14synaptic vesicle exocytosis (GO:0016079)4.98092505
15establishment of integrated proviral latency (GO:0075713)4.95968905
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.91715653
17negative regulation of synaptic transmission, GABAergic (GO:0032229)4.84395436
18negative regulation of mast cell activation (GO:0033004)4.76898852
19histone deubiquitination (GO:0016578)4.75602561
20nuclear pore complex assembly (GO:0051292)4.60057019
21positive regulation of growth hormone secretion (GO:0060124)4.57378945
22regulation of glutamate receptor signaling pathway (GO:1900449)4.56334509
23positive regulation of T cell apoptotic process (GO:0070234)4.55898135
24central nervous system projection neuron axonogenesis (GO:0021952)4.40800198
25somatic hypermutation of immunoglobulin genes (GO:0016446)4.40683995
26somatic diversification of immune receptors via somatic mutation (GO:0002566)4.40683995
27gamma-aminobutyric acid transport (GO:0015812)4.38180761
28negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)4.35359210
29positive regulation of heat generation (GO:0031652)4.34661633
30nucleobase catabolic process (GO:0046113)4.32958133
31folic acid metabolic process (GO:0046655)4.27175271
32substrate-independent telencephalic tangential migration (GO:0021826)4.24152296
33substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.24152296
34regulation of penile erection (GO:0060405)4.22715938
35layer formation in cerebral cortex (GO:0021819)4.22638430
36positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.22101077
37regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.22101077
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.21960281
39regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 4.19456287
40regulation of histone H3-K9 methylation (GO:0051570)4.17447531
41B cell receptor signaling pathway (GO:0050853)4.14354007
42neurotransmitter secretion (GO:0007269)4.12663109
43cellular sodium ion homeostasis (GO:0006883)4.12006588
44folic acid transport (GO:0015884)4.11255260
45gamma-aminobutyric acid signaling pathway (GO:0007214)4.10111219
46L-serine metabolic process (GO:0006563)4.09211108
47positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.05401709
48regulation of short-term neuronal synaptic plasticity (GO:0048172)3.96618213
49DNA strand elongation involved in DNA replication (GO:0006271)3.96434111
50multicellular organismal reproductive behavior (GO:0033057)3.93802288
51nuclear pore organization (GO:0006999)3.92366785
52regulation of glutamate secretion (GO:0014048)3.92114287
53neuron recognition (GO:0008038)3.90831396
54tachykinin receptor signaling pathway (GO:0007217)3.84811016
55negative regulation of DNA recombination (GO:0045910)3.83848183
56somatic diversification of immunoglobulins (GO:0016445)3.83310759
57DNA double-strand break processing (GO:0000729)3.83273757
58negative regulation of fibroblast apoptotic process (GO:2000270)3.83256353
59regulation of helicase activity (GO:0051095)3.82421211
60positive regulation of dendritic spine morphogenesis (GO:0061003)3.81355105
61glutamate secretion (GO:0014047)3.79217250
62establishment of viral latency (GO:0019043)3.77551871
63DNA strand elongation (GO:0022616)3.72011105
64cerebral cortex radially oriented cell migration (GO:0021799)3.69770567
65positive regulation of lymphocyte apoptotic process (GO:0070230)3.67016648
66negative regulation of stem cell proliferation (GO:2000647)3.60842367
67L-alpha-amino acid transmembrane transport (GO:1902475)3.60667733
68regulation of action potential (GO:0098900)3.60133500
69pre-miRNA processing (GO:0031054)3.59168446
70regulation of glucocorticoid secretion (GO:2000849)3.52049173
71regulation of synaptic transmission, GABAergic (GO:0032228)3.51855982
72somatic recombination of immunoglobulin gene segments (GO:0016447)3.50669448
73regulation of growth hormone secretion (GO:0060123)3.48702426
74folic acid-containing compound biosynthetic process (GO:0009396)3.46847395
75positive regulation of action potential (GO:0045760)3.46160645
76telomere maintenance via telomerase (GO:0007004)3.45398554
77succinate metabolic process (GO:0006105)3.45396517
78axonal fasciculation (GO:0007413)3.44146673
79adult feeding behavior (GO:0008343)3.42927916
80somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.41467768
81isotype switching (GO:0045190)3.41467768
82somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.41467768
83negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)3.40934931
84central nervous system neuron axonogenesis (GO:0021955)3.40031713
85negative regulation of androgen receptor signaling pathway (GO:0060766)3.39418395
86B cell proliferation (GO:0042100)3.38991215
87negative regulation of histone methylation (GO:0031061)3.36804745
88regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.35436702
89regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)3.34535192
90IMP biosynthetic process (GO:0006188)3.34322971
91olfactory bulb development (GO:0021772)3.34196607
92positive regulation of meiosis (GO:0045836)3.34071549
93negative regulation of catecholamine secretion (GO:0033604)3.33939019
94negative regulation of interleukin-1 beta production (GO:0032691)3.32666584
95regulation of amino acid transport (GO:0051955)3.32426178
96neuronal action potential propagation (GO:0019227)3.32204999
97neurotransmitter-gated ion channel clustering (GO:0072578)3.32069168
98protein complex localization (GO:0031503)3.31453270
99protein localization to kinetochore (GO:0034501)3.29890099
100multi-organism reproductive behavior (GO:0044705)3.29548888
101indolalkylamine catabolic process (GO:0046218)3.29513881
102tryptophan catabolic process (GO:0006569)3.29513881
103indole-containing compound catabolic process (GO:0042436)3.29513881
104behavioral response to nicotine (GO:0035095)3.28672022
105chaperone-mediated protein transport (GO:0072321)3.27417120
106regulation of heat generation (GO:0031650)3.26545529
107positive regulation of CREB transcription factor activity (GO:0032793)3.26275906
108pore complex assembly (GO:0046931)3.23973634
109regulation of meiosis I (GO:0060631)3.22876384
110regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.22171010
111regulation of mitotic spindle checkpoint (GO:1903504)3.22171010
112DNA damage response, detection of DNA damage (GO:0042769)3.21438278
113negative regulation of protein localization to cell surface (GO:2000009)3.21298630
114regulation of protein homooligomerization (GO:0032462)3.19435997
115folic acid-containing compound metabolic process (GO:0006760)3.18905707
116negative regulation of circadian rhythm (GO:0042754)3.18877682
117telomere maintenance via semi-conservative replication (GO:0032201)3.18158235
118negative regulation of DNA-dependent DNA replication (GO:2000104)3.16806511
119chromatin remodeling at centromere (GO:0031055)3.16473669
120positive regulation of steroid hormone secretion (GO:2000833)3.16270186
121serine family amino acid biosynthetic process (GO:0009070)3.15682398
122cerebral cortex cell migration (GO:0021795)3.14803651
123somatic diversification of immune receptors (GO:0002200)3.14238773
124growth hormone secretion (GO:0030252)3.13461833
125membrane hyperpolarization (GO:0060081)3.11478032
126neurofilament cytoskeleton organization (GO:0060052)3.10526381
127rRNA modification (GO:0000154)3.07618586
128reproductive behavior (GO:0019098)3.07221367
129CENP-A containing nucleosome assembly (GO:0034080)3.05331459
130rRNA methylation (GO:0031167)3.05166811
131neurotransmitter transport (GO:0006836)3.04221013
132negative regulation of nitric-oxide synthase activity (GO:0051001)3.02031913
133response to histamine (GO:0034776)3.00784743
134positive regulation of meiotic cell cycle (GO:0051446)3.00456618
135negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98646946
136negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.98646946
137negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98646946
138negative regulation of mitotic sister chromatid separation (GO:2000816)2.98646946
139negative regulation of sister chromatid segregation (GO:0033046)2.98646946
140negative regulation of membrane potential (GO:0045837)2.98182593
141negative regulation of chromosome segregation (GO:0051985)2.98072402
142ionotropic glutamate receptor signaling pathway (GO:0035235)2.97475484
143positive regulation of synapse assembly (GO:0051965)2.96387105
144detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.96058045
145regulation of germinal center formation (GO:0002634)2.95842743
146negative regulation of signal transduction by p53 class mediator (GO:1901797)2.95777881
147protein localization to synapse (GO:0035418)2.94243561
148hindbrain development (GO:0030902)2.93759161
149negative regulation of keratinocyte proliferation (GO:0010839)2.93047483
150parturition (GO:0007567)2.92532785
151regulation of fibroblast apoptotic process (GO:2000269)2.91880968
152natural killer cell activation involved in immune response (GO:0002323)2.91761277
153detection of calcium ion (GO:0005513)2.90730072
154synapse assembly (GO:0007416)2.90253808
155transmission of nerve impulse (GO:0019226)2.86777957
156establishment of synaptic vesicle localization (GO:0097480)2.86564575
157synaptic vesicle transport (GO:0048489)2.86564575
158non-recombinational repair (GO:0000726)2.86071302
159double-strand break repair via nonhomologous end joining (GO:0006303)2.86071302
160somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.85209497
161somatic cell DNA recombination (GO:0016444)2.85209497
162regulation of spindle checkpoint (GO:0090231)2.84103939
163proteasome assembly (GO:0043248)2.83456563
164RNA-dependent DNA replication (GO:0006278)2.83116626
165telomere maintenance via telomere lengthening (GO:0010833)2.81586678
166telomere maintenance via recombination (GO:0000722)2.81071155
167* response to cocaine (GO:0042220)2.80923617
168IMP metabolic process (GO:0046040)2.80711587
169negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80350601
170regulation of fever generation (GO:0031620)2.80231117
171positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.78597641
172positive thymic T cell selection (GO:0045059)2.78491586
173negative regulation of dendrite morphogenesis (GO:0050774)2.76918935
174axon extension (GO:0048675)2.76461739
175cellular response to gamma radiation (GO:0071480)2.75054890
176negative regulation of response to DNA damage stimulus (GO:2001021)2.74825402
177DNA replication-independent nucleosome organization (GO:0034724)2.74643691
178DNA replication-independent nucleosome assembly (GO:0006336)2.74643691
179female gonad development (GO:0008585)2.74567230
180regulation of neurotransmitter levels (GO:0001505)2.74542944
181regulation of mitotic metaphase/anaphase transition (GO:0030071)2.74512618
182regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.74512618
183locomotory exploration behavior (GO:0035641)2.73685852
184negative regulation of B cell apoptotic process (GO:0002903)2.73440324
185tetrahydrofolate metabolic process (GO:0046653)2.73435672
186membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72651436
187mitotic nuclear envelope disassembly (GO:0007077)2.72599080
188positive regulation of cell cycle checkpoint (GO:1901978)2.72217441
189mitotic metaphase plate congression (GO:0007080)2.71541296
190spinal cord development (GO:0021510)2.70682030
191neuron-neuron synaptic transmission (GO:0007270)2.70312339
192regulation of response to food (GO:0032095)2.70272037
193base-excision repair (GO:0006284)2.70155825
194protein-cofactor linkage (GO:0018065)2.69670499
195protein localization to chromosome, centromeric region (GO:0071459)2.69518981

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human9.65055632
2E2F7_22180533_ChIP-Seq_HELA_Human7.64092849
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.13514200
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.09570153
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.03776241
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.37953239
7GBX2_23144817_ChIP-Seq_PC3_Human3.25274131
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.17379984
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.12455185
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.90389392
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88095316
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.78568868
13MYC_22102868_ChIP-Seq_BL_Human2.78018171
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.77627196
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71025136
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.70340711
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.68032084
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66986128
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59096114
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.51252561
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.48449399
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45248537
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40563470
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40301037
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37442399
26ELK1_19687146_ChIP-ChIP_HELA_Human2.33901233
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33568926
28ZNF274_21170338_ChIP-Seq_K562_Hela2.26575393
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.26206397
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.24474449
31EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22889551
32RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22889551
33E2F1_21310950_ChIP-Seq_MCF-7_Human2.22523961
34EZH2_27304074_Chip-Seq_ESCs_Mouse2.22081676
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18783865
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18568170
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16931435
38* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13883847
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12093801
40SMAD_19615063_ChIP-ChIP_OVARY_Human2.09180082
41ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08841346
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07530366
43FOXP3_21729870_ChIP-Seq_TREG_Human2.02539079
44CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01021995
45HOXB4_20404135_ChIP-ChIP_EML_Mouse2.00491010
46* REST_21632747_ChIP-Seq_MESCs_Mouse1.95940607
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94985358
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94829691
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.92446010
50* P300_19829295_ChIP-Seq_ESCs_Human1.90860789
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.90798460
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.89321671
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88843789
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87655432
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.87200405
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87069047
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85400903
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.84410800
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84276923
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84060880
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84037450
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83973736
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83631385
64TAF15_26573619_Chip-Seq_HEK293_Human1.82406333
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79382102
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79287818
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.78465966
68IGF1R_20145208_ChIP-Seq_DFB_Human1.78296994
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.76337379
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74589624
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.69307724
72SOX2_16153702_ChIP-ChIP_HESCs_Human1.69036115
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.66443059
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64166755
75AR_21909140_ChIP-Seq_LNCAP_Human1.63032770
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62392000
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62204034
78JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62152838
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.59656548
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.58642435
81SMAD4_21799915_ChIP-Seq_A2780_Human1.55243450
82* REST_18959480_ChIP-ChIP_MESCs_Mouse1.54442629
83VDR_23849224_ChIP-Seq_CD4+_Human1.54432408
84FUS_26573619_Chip-Seq_HEK293_Human1.54351166
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54128092
86RARB_27405468_Chip-Seq_BRAIN_Mouse1.53567366
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53559390
88NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52089426
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.52071641
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.50957651
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50713617
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.49951750
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49459978
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.47834964
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.47834964
96KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.47834964
97TTF2_22483619_ChIP-Seq_HELA_Human1.46721391
98AR_21572438_ChIP-Seq_LNCaP_Human1.45879331
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44955916
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43879458
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43879458
102DROSHA_22980978_ChIP-Seq_HELA_Human1.41488704
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.40302367
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38543959
105IRF8_21731497_ChIP-ChIP_J774_Mouse1.37230428
106SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37151932
107ZNF263_19887448_ChIP-Seq_K562_Human1.36303855
108POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35668534
109STAT3_23295773_ChIP-Seq_U87_Human1.35511388
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35178288
111* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34515618
112XRN2_22483619_ChIP-Seq_HELA_Human1.34089522
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.30712785
114NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.30262782
115RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30097592
116CIITA_25753668_ChIP-Seq_RAJI_Human1.29840602
117BCAT_22108803_ChIP-Seq_LS180_Human1.29840108
118POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29449632
119ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28831521
120BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28653673
121ER_23166858_ChIP-Seq_MCF-7_Human1.27963911
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27851893
123RING1B_27294783_Chip-Seq_NPCs_Mouse1.26449355
124SOX2_21211035_ChIP-Seq_LN229_Gbm1.25632105
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.25197882
126SMAD3_21741376_ChIP-Seq_HESCs_Human1.24577582
127TP53_16413492_ChIP-PET_HCT116_Human1.23681229
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23014943
129IRF1_19129219_ChIP-ChIP_H3396_Human1.22763826
130TBX3_20139965_ChIP-Seq_ESCs_Mouse1.22312085
131TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21656207
132ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21256494
133MYC_18940864_ChIP-ChIP_HL60_Human1.19501251
134IRF8_22096565_ChIP-ChIP_GC-B_Human1.19316601
135AR_19668381_ChIP-Seq_PC3_Human1.18306006
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16780068
137FLI1_27457419_Chip-Seq_LIVER_Mouse1.16722462
138NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.15218076
139SOX9_26525672_Chip-Seq_HEART_Mouse1.14934281
140MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14261908
141RUNX2_22187159_ChIP-Seq_PCA_Human1.12880940
142SRF_21415370_ChIP-Seq_HL-1_Mouse1.12207306
143KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12127970
144POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12021601
145AR_25329375_ChIP-Seq_VCAP_Human1.10784487
146TP53_18474530_ChIP-ChIP_U2OS_Human1.10680647
147* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09027646
148RNF2_27304074_Chip-Seq_NSC_Mouse1.08513656
149TCF4_23295773_ChIP-Seq_U87_Human1.08469300
150ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08367459
151E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08047793
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06902457
153TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06610076
154RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06303410
155GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06262369
156ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04657383
157FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03054756
158SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02696212
159TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02179368
160YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02133567
161* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00120256
162KDM2B_26808549_Chip-Seq_REH_Human1.00040160
163NANOG_18555785_Chip-Seq_ESCs_Mouse0.99919386
164ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99661868
165CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98787724
166LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98429224
167ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97221763
168ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97198216
169TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97001930
170WDR5_24793694_ChIP-Seq_LNCAP_Human0.96917554
171RING1B_27294783_Chip-Seq_ESCs_Mouse0.96717943
172PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95959049
173PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95900975
174JUN_21703547_ChIP-Seq_K562_Human0.94813826
175HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94023861
176FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93699518
177GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93365333
178KDM5A_27292631_Chip-Seq_BREAST_Human0.93028411
179FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92668244
180P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91586850
181STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88876495
182ELK1_22589737_ChIP-Seq_MCF10A_Human0.88330810
183SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86979212
184DCP1A_22483619_ChIP-Seq_HELA_Human0.84469007
185STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84065370
186SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83224969
187SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82599316
188POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.82325522
189OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81538990
190PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79690612
191EGR1_23403033_ChIP-Seq_LIVER_Mouse0.79478335

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.02731900
2MP0003693_abnormal_embryo_hatching4.85889664
3MP0009046_muscle_twitch4.10044315
4MP0010094_abnormal_chromosome_stability3.73639734
5MP0004859_abnormal_synaptic_plasticity3.71553189
6MP0004957_abnormal_blastocyst_morpholog3.48547375
7MP0003635_abnormal_synaptic_transmissio3.27074804
8MP0003111_abnormal_nucleus_morphology3.20809390
9MP0008058_abnormal_DNA_repair3.20134544
10MP0003077_abnormal_cell_cycle3.04723964
11MP0009745_abnormal_behavioral_response3.01218250
12MP0002254_reproductive_system_inflammat3.00337399
13MP0000778_abnormal_nervous_system2.96811610
14MP0002064_seizures2.90633370
15* MP0002735_abnormal_chemical_nociception2.80508584
16MP0003787_abnormal_imprinting2.72658247
17MP0003941_abnormal_skin_development2.71744375
18MP0008057_abnormal_DNA_replication2.60091510
19MP0001177_atelectasis2.53171216
20MP0008932_abnormal_embryonic_tissue2.51675684
21MP0002063_abnormal_learning/memory/cond2.48777303
22MP0009384_cardiac_valve_regurgitation2.47245417
23MP0000013_abnormal_adipose_tissue2.42484871
24MP0002572_abnormal_emotion/affect_behav2.37017324
25MP0008877_abnormal_DNA_methylation2.26635100
26MP0001853_heart_inflammation2.25334398
27MP0006292_abnormal_olfactory_placode2.20764677
28MP0008007_abnormal_cellular_replicative2.19048533
29MP0005367_renal/urinary_system_phenotyp2.18108871
30MP0000516_abnormal_urinary_system2.18108871
31MP0001486_abnormal_startle_reflex2.12139131
32MP0005423_abnormal_somatic_nervous2.11149295
33MP0001800_abnormal_humoral_immune2.10832681
34MP0006276_abnormal_autonomic_nervous1.94175279
35* MP0002184_abnormal_innervation1.93968055
36MP0002272_abnormal_nervous_system1.90674371
37MP0004133_heterotaxia1.90415553
38MP0002557_abnormal_social/conspecific_i1.88857246
39MP0002734_abnormal_mechanical_nocicepti1.82132613
40MP0001730_embryonic_growth_arrest1.81433455
41MP0003880_abnormal_central_pattern1.79856736
42MP0004270_analgesia1.78087256
43MP0002067_abnormal_sensory_capabilities1.77721875
44MP0003786_premature_aging1.72070454
45MP0002751_abnormal_autonomic_nervous1.71616918
46MP0004019_abnormal_vitamin_homeostasis1.70354812
47MP0003763_abnormal_thymus_physiology1.66573020
48MP0000350_abnormal_cell_proliferation1.65801097
49MP0005386_behavior/neurological_phenoty1.65205084
50MP0004924_abnormal_behavior1.65205084
51MP0004134_abnormal_chest_morphology1.64895032
52MP0004885_abnormal_endolymph1.64426609
53MP0005310_abnormal_salivary_gland1.63695417
54MP0001188_hyperpigmentation1.61865666
55* MP0010386_abnormal_urinary_bladder1.59801217
56MP0004811_abnormal_neuron_physiology1.53273656
57MP0002452_abnormal_antigen_presenting1.49716164
58MP0009672_abnormal_birth_weight1.49097779
59MP0005000_abnormal_immune_tolerance1.47575911
60MP0002396_abnormal_hematopoietic_system1.44907830
61MP0002009_preneoplasia1.44883216
62MP0010352_gastrointestinal_tract_polyps1.43453606
63MP0001835_abnormal_antigen_presentation1.42250832
64MP0000490_abnormal_crypts_of1.37978034
65MP0000689_abnormal_spleen_morphology1.37598580
66MP0004742_abnormal_vestibular_system1.37034143
67MP0006035_abnormal_mitochondrial_morpho1.36998033
68MP0003656_abnormal_erythrocyte_physiolo1.35469505
69MP0000955_abnormal_spinal_cord1.33917622
70MP0001968_abnormal_touch/_nociception1.33744809
71MP0000372_irregular_coat_pigmentation1.33231049
72MP0002234_abnormal_pharynx_morphology1.32912869
73MP0002837_dystrophic_cardiac_calcinosis1.32436335
74MP0008569_lethality_at_weaning1.32281717
75MP0002733_abnormal_thermal_nociception1.31981520
76MP0002133_abnormal_respiratory_system1.31841522
77MP0005388_respiratory_system_phenotype1.31841522
78MP0008995_early_reproductive_senescence1.30054190
79MP0002066_abnormal_motor_capabilities/c1.29590372
80MP0001790_abnormal_immune_system1.27383942
81MP0005387_immune_system_phenotype1.27383942
82MP0003195_calcinosis1.23597759
83MP0001501_abnormal_sleep_pattern1.23066420
84* MP0002398_abnormal_bone_marrow1.22420876
85MP0005171_absent_coat_pigmentation1.21787720
86MP0000313_abnormal_cell_death1.21037289
87MP0002233_abnormal_nose_morphology1.20561408
88MP0002882_abnormal_neuron_morphology1.19820244
89MP0002152_abnormal_brain_morphology1.18802197
90MP0002736_abnormal_nociception_after1.17772727
91MP0003938_abnormal_ear_development1.17216987
92MP0002909_abnormal_adrenal_gland1.16935000
93MP0001672_abnormal_embryogenesis/_devel1.16931505
94MP0005380_embryogenesis_phenotype1.16931505
95MP0003890_abnormal_embryonic-extraembry1.16273460
96* MP0000538_abnormal_urinary_bladder1.15865491
97MP0002638_abnormal_pupillary_reflex1.13558764
98MP0001986_abnormal_taste_sensitivity1.13275172
99MP0000631_abnormal_neuroendocrine_gland1.11073543
100MP0003567_abnormal_fetal_cardiomyocyte1.11052686
101MP0004782_abnormal_surfactant_physiolog1.10541520
102MP0000678_abnormal_parathyroid_gland1.09353120
103* MP0001970_abnormal_pain_threshold1.09236949
104MP0003011_delayed_dark_adaptation1.05984809
105MP0001963_abnormal_hearing_physiology1.05911542
106MP0003385_abnormal_body_wall1.05768328
107MP0003984_embryonic_growth_retardation1.04258648
108MP0000579_abnormal_nail_morphology1.04150863
109MP0004858_abnormal_nervous_system1.03837479
110MP0002080_prenatal_lethality1.03655207
111MP0002420_abnormal_adaptive_immunity1.03430293
112MP0003755_abnormal_palate_morphology1.02597642
113MP0001943_abnormal_respiration1.02251929
114MP0002722_abnormal_immune_system1.01311445
115MP0002088_abnormal_embryonic_growth/wei1.01122695
116MP0005646_abnormal_pituitary_gland0.99843990
117MP0002085_abnormal_embryonic_tissue0.99493044
118MP0001958_emphysema0.99028907
119MP0002069_abnormal_eating/drinking_beha0.98729252
120MP0003632_abnormal_nervous_system0.98100528
121MP0001440_abnormal_grooming_behavior0.97854324
122MP0003718_maternal_effect0.97709358
123MP0002277_abnormal_respiratory_mucosa0.97676541
124MP0004085_abnormal_heartbeat0.97182522
125MP0001819_abnormal_immune_cell0.96727900
126MP0002723_abnormal_immune_serum0.95633678
127MP0002796_impaired_skin_barrier0.95591843
128MP0003861_abnormal_nervous_system0.95516086
129MP0008872_abnormal_physiological_respon0.95431586
130MP0000427_abnormal_hair_cycle0.94429158
131MP0005332_abnormal_amino_acid0.93277411
132MP0001666_abnormal_nutrient_absorption0.93235261
133MP0002019_abnormal_tumor_incidence0.92757859
134* MP0000716_abnormal_immune_system0.92685072
135MP0005266_abnormal_metabolism0.92424930
136MP0000015_abnormal_ear_pigmentation0.91207586
137MP0001697_abnormal_embryo_size0.91108022
138MP0002084_abnormal_developmental_patter0.91017161
139MP0002081_perinatal_lethality0.90719860
140MP0004142_abnormal_muscle_tone0.90199914
141MP0000026_abnormal_inner_ear0.90096640
142MP0005395_other_phenotype0.89581263
143MP0001984_abnormal_olfaction0.88215967
144MP0002082_postnatal_lethality0.88113368
145MP0010770_preweaning_lethality0.88113368
146MP0003115_abnormal_respiratory_system0.87967182
147MP0005645_abnormal_hypothalamus_physiol0.86282821
148MP0002177_abnormal_outer_ear0.84567221
149MP0003566_abnormal_cell_adhesion0.84209846
150MP0002876_abnormal_thyroid_physiology0.83653321
151MP0001502_abnormal_circadian_rhythm0.83296587
152MP0000703_abnormal_thymus_morphology0.83059784
153MP0002693_abnormal_pancreas_physiology0.82103075
154* MP0002429_abnormal_blood_cell0.81944979
155MP0005394_taste/olfaction_phenotype0.79683102
156MP0005499_abnormal_olfactory_system0.79683102
157MP0005501_abnormal_skin_physiology0.78249993
158MP0003121_genomic_imprinting0.77636289
159MP0003329_amyloid_beta_deposits0.76915878
160MP0002210_abnormal_sex_determination0.75726675
161MP0003137_abnormal_impulse_conducting0.75686338
162MP0001881_abnormal_mammary_gland0.74889577
163MP0010769_abnormal_survival0.74600135
164MP0009703_decreased_birth_body0.74392813
165MP0005220_abnormal_exocrine_pancreas0.73410664
166MP0003948_abnormal_gas_homeostasis0.73341084
167MP0000049_abnormal_middle_ear0.73243387
168MP0002752_abnormal_somatic_nervous0.72833478
169MP0002090_abnormal_vision0.72690422
170MP0001270_distended_abdomen0.72616956
171MP0000685_abnormal_immune_system0.69668922
172MP0009697_abnormal_copulation0.69068538
173MP0002148_abnormal_hypersensitivity_rea0.68615108
174* MP0001145_abnormal_male_reproductive0.65665410
175MP0009765_abnormal_xenobiotic_induced0.64800791
176MP0003943_abnormal_hepatobiliary_system0.63556163
177MP0003937_abnormal_limbs/digits/tail_de0.62290955
178MP0006036_abnormal_mitochondrial_physio0.60310730
179MP0001929_abnormal_gametogenesis0.58714342
180MP0001905_abnormal_dopamine_level0.57645222
181MP0002086_abnormal_extraembryonic_tissu0.57142838
182MP0005647_abnormal_sex_gland0.55126345

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)8.99973451
2Large eyes (HP:0001090)7.24555742
3Focal motor seizures (HP:0011153)5.71569148
4Gastrointestinal stroma tumor (HP:0100723)5.63916931
5Thickened helices (HP:0000391)5.23262752
6Absent speech (HP:0001344)4.70004257
7Agammaglobulinemia (HP:0004432)4.61760414
8Fibular hypoplasia (HP:0003038)4.55818624
9Recurrent sinusitis (HP:0011108)4.31906434
10Febrile seizures (HP:0002373)4.25901157
11Atonic seizures (HP:0010819)4.21124289
12Progressive inability to walk (HP:0002505)4.15783174
13Protruding tongue (HP:0010808)4.11382283
14IgM deficiency (HP:0002850)4.11345091
15Decreased circulating renin level (HP:0003351)4.09656172
16Lymphopenia (HP:0001888)3.98309890
17Limb dystonia (HP:0002451)3.56070450
18Abnormality of cells of the lymphoid lineage (HP:0012140)3.47649647
19Hypochromic microcytic anemia (HP:0004840)3.33741118
20Medulloblastoma (HP:0002885)3.32524338
21Intellectual disability, progressive (HP:0006887)3.20797373
22Focal seizures (HP:0007359)3.19063821
23Pachygyria (HP:0001302)3.16102717
24Increased circulating renin level (HP:0000848)3.15848656
25Gastroesophageal reflux (HP:0002020)3.15802156
26Agnosia (HP:0010524)3.14377929
27Abnormality of chromosome stability (HP:0003220)3.12964248
28Amblyopia (HP:0000646)3.11783373
29Abnormal hair whorl (HP:0010721)3.09721214
30Carpal bone hypoplasia (HP:0001498)3.09048091
31IgA deficiency (HP:0002720)3.06823248
32Epileptic encephalopathy (HP:0200134)3.06506094
33Aplasia/Hypoplasia of the uvula (HP:0010293)3.06149889
34Reticulocytopenia (HP:0001896)2.91636516
35Hyperactive renin-angiotensin system (HP:0000841)2.91382797
36Intellectual disability, severe (HP:0010864)2.90597806
37Rhabdomyosarcoma (HP:0002859)2.90341949
3811 pairs of ribs (HP:0000878)2.87849519
39Lymphoma (HP:0002665)2.82215162
40Ependymoma (HP:0002888)2.82144055
41Spastic paraparesis (HP:0002313)2.81445191
42Excessive salivation (HP:0003781)2.75759041
43Drooling (HP:0002307)2.75759041
44Absence seizures (HP:0002121)2.73779455
45Dialeptic seizures (HP:0011146)2.68955367
46Impulsivity (HP:0100710)2.68867088
47Aplasia/Hypoplasia of the fibula (HP:0006492)2.66881108
48Abnormal lung lobation (HP:0002101)2.66427126
49Shoulder girdle muscle weakness (HP:0003547)2.63674635
50Recurrent bronchitis (HP:0002837)2.62570254
51Widely spaced teeth (HP:0000687)2.61936864
52Emphysema (HP:0002097)2.59642149
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55747550
54Abnormality of the preputium (HP:0100587)2.54778671
55Cupped ear (HP:0000378)2.54611785
56Limb hypertonia (HP:0002509)2.53737891
57Cellular immunodeficiency (HP:0005374)2.53218554
58Bronchitis (HP:0012387)2.53129604
59Recurrent pneumonia (HP:0006532)2.52732539
60Stenosis of the external auditory canal (HP:0000402)2.50907377
61Generalized tonic-clonic seizures (HP:0002069)2.50674658
62Mitral stenosis (HP:0001718)2.50625537
63Poor eye contact (HP:0000817)2.50157253
64Inability to walk (HP:0002540)2.47521992
65Lissencephaly (HP:0001339)2.45299404
66Abnormal social behavior (HP:0012433)2.44862991
67Impaired social interactions (HP:0000735)2.44862991
68Ridged nail (HP:0001807)2.41369989
69Panhypogammaglobulinemia (HP:0003139)2.41084340
70Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.40490803
71Overlapping toe (HP:0001845)2.40460763
72Athetosis (HP:0002305)2.40429398
73Chronic bronchitis (HP:0004469)2.39397749
74Partial agenesis of the corpus callosum (HP:0001338)2.39298855
75Oral leukoplakia (HP:0002745)2.38979044
76Obstructive sleep apnea (HP:0002870)2.36611210
77Nephroblastoma (Wilms tumor) (HP:0002667)2.35198026
78Clitoromegaly (HP:0000057)2.32480006
79Bilateral microphthalmos (HP:0007633)2.32405838
80Broad-based gait (HP:0002136)2.27728125
81Leukopenia (HP:0001882)2.26522687
82Recurrent lower respiratory tract infections (HP:0002783)2.26359962
83Neoplasm of the pancreas (HP:0002894)2.24072702
84Esophageal atresia (HP:0002032)2.23568686
85Poor speech (HP:0002465)2.23150892
86Osteomyelitis (HP:0002754)2.22661237
87Biliary tract neoplasm (HP:0100574)2.21991444
88Tented upper lip vermilion (HP:0010804)2.21604845
89Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.21193734
90Colitis (HP:0002583)2.20872199
91Abnormality of endocrine pancreas physiology (HP:0012093)2.20411779
92Abnormality of the pancreatic islet cells (HP:0006476)2.20411779
93Abnormality of the right ventricle (HP:0001707)2.20383977
94Birth length less than 3rd percentile (HP:0003561)2.19062691
95Chromsome breakage (HP:0040012)2.18854118
96Embryonal renal neoplasm (HP:0011794)2.18758810
97Tetraplegia (HP:0002445)2.17653250
98IgG deficiency (HP:0004315)2.15734485
99Multiple enchondromatosis (HP:0005701)2.14475708
100Exotropia (HP:0000577)2.10597864
101Shawl scrotum (HP:0000049)2.08764310
102Selective tooth agenesis (HP:0001592)2.08692155
103Abnormality of the labia minora (HP:0012880)2.08296120
104Tapered finger (HP:0001182)2.07956547
105Meckel diverticulum (HP:0002245)2.07866145
106Septo-optic dysplasia (HP:0100842)2.06958394
107Abnormality of homocysteine metabolism (HP:0010919)2.06848970
108Homocystinuria (HP:0002156)2.06848970
109Fetal akinesia sequence (HP:0001989)2.05715954
110Pancreatic islet-cell hyperplasia (HP:0004510)2.05609232
111Tachypnea (HP:0002789)2.03058695
112Absent frontal sinuses (HP:0002688)2.01529792
113Sloping forehead (HP:0000340)2.01477221
114Abnormality of the clitoris (HP:0000056)2.01447772
115Duodenal stenosis (HP:0100867)1.99844945
116Small intestinal stenosis (HP:0012848)1.99844945
117Chronic sinusitis (HP:0011109)1.99471453
118Sleep apnea (HP:0010535)1.98969955
119Visual hallucinations (HP:0002367)1.98811743
120Abnormality of the ileum (HP:0001549)1.98558016
121Abnormality of macular pigmentation (HP:0008002)1.97980840
122Agitation (HP:0000713)1.97098049
123Horseshoe kidney (HP:0000085)1.96699287
124Rectal prolapse (HP:0002035)1.96640076
125Hypsarrhythmia (HP:0002521)1.96292174
126Hematochezia (HP:0002573)1.95701629
127Clubbing of toes (HP:0100760)1.95431699
128Open mouth (HP:0000194)1.95115627
129EEG with generalized epileptiform discharges (HP:0011198)1.95057906
130Gait ataxia (HP:0002066)1.92691994
131Spastic tetraplegia (HP:0002510)1.92485997
132Abnormality of the duodenum (HP:0002246)1.91694556
133Short tibia (HP:0005736)1.91150468
134Glioma (HP:0009733)1.90846798
135Epileptiform EEG discharges (HP:0011182)1.90275499
136Meningitis (HP:0001287)1.90050553
137Abnormality of the septum pellucidum (HP:0007375)1.90015860
138Restrictive lung disease (HP:0002091)1.89382180
139Cutaneous melanoma (HP:0012056)1.89166486
140Intestinal atresia (HP:0011100)1.88381767
141Missing ribs (HP:0000921)1.87948449
142Generalized myoclonic seizures (HP:0002123)1.87917682
143Recurrent otitis media (HP:0000403)1.87614112
144Neoplasm of striated muscle (HP:0009728)1.85812632
145Toxemia of pregnancy (HP:0100603)1.85440088
146Abnormal finger flexion creases (HP:0006143)1.84953467
147Broad alveolar ridges (HP:0000187)1.84952149
148Segmental peripheral demyelination/remyelination (HP:0003481)1.84569863
149Hyperthyroidism (HP:0000836)1.83198758
150Esotropia (HP:0000565)1.82407029
151Abnormality of the astrocytes (HP:0100707)1.80871067
152Astrocytoma (HP:0009592)1.80871067
153Congenital, generalized hypertrichosis (HP:0004540)1.80741439
154Chronic hepatic failure (HP:0100626)1.80720412
155Ulnar claw (HP:0001178)1.79229158
156Colon cancer (HP:0003003)1.78764370
157Blue irides (HP:0000635)1.78641550
158Papillary thyroid carcinoma (HP:0002895)1.78331670
159Paraparesis (HP:0002385)1.77539644
160X-linked dominant inheritance (HP:0001423)1.77047128
161Hypoglycemic seizures (HP:0002173)1.76736354
162Dislocated radial head (HP:0003083)1.76167520
163Breast carcinoma (HP:0003002)1.75972863
164Abnormality of salivation (HP:0100755)1.75792439
165Abnormality of incisor morphology (HP:0011063)1.74476346
166Bifid tongue (HP:0010297)1.74368182
167Abnormality of the radial head (HP:0003995)1.74223042
168Retinal dysplasia (HP:0007973)1.73756214
169Hyperglycinuria (HP:0003108)1.73698418
170Truncus arteriosus (HP:0001660)1.72439955
171Mediastinal lymphadenopathy (HP:0100721)1.71573947
172Macrocytic anemia (HP:0001972)1.70915631
173Steatorrhea (HP:0002570)1.70466989
174Sparse eyelashes (HP:0000653)1.69412525
175Viral hepatitis (HP:0006562)1.69097679
176Poor suck (HP:0002033)1.68251919
177Abnormality of small intestinal villus morphology (HP:0011472)1.68185914
178Villous atrophy (HP:0011473)1.68185914
179Optic nerve coloboma (HP:0000588)1.67230076
180Absent septum pellucidum (HP:0001331)1.66752886
181Abnormality of methionine metabolism (HP:0010901)1.66527886
182Type 2 muscle fiber atrophy (HP:0003554)1.66257390
183Rough bone trabeculation (HP:0100670)1.65593081
184Abnormality of glycine metabolism (HP:0010895)1.64352888
185Abnormality of serine family amino acid metabolism (HP:0010894)1.64352888
186Abnormality of the prostate (HP:0008775)1.64121622
187Aplastic anemia (HP:0001915)1.63475775
188Choanal stenosis (HP:0000452)1.60610331

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK7.14101455
2MAP3K45.37415845
3MAP2K75.17774093
4MST44.76075440
5MARK14.00134520
6CDC73.61265371
7YES13.17539117
8BUB13.16967995
9PRKD33.06965694
10TSSK62.98140448
11MAP2K42.92905144
12BLK2.87811072
13SRPK12.84305106
14CAMK1G2.79208515
15EIF2AK22.72451065
16MAP4K12.72327388
17MAP3K102.70674558
18VRK22.56715725
19BMPR1B2.46816127
20TTK2.43670761
21EIF2AK32.43199015
22NTRK22.36806388
23CASK2.14103861
24OXSR12.09608097
25MAP3K91.99249531
26ERBB41.91316732
27SGK21.89771781
28MKNK21.84961632
29TAOK21.82127592
30STK391.79311030
31PBK1.77781084
32LMTK21.69876460
33TAF11.69477933
34BRSK21.65808865
35NTRK31.62347599
36PDK21.60588596
37SMG11.58041336
38CSF1R1.53971630
39ITK1.50789789
40PIK3CG1.48461724
41EPHB21.48435644
42SGK4941.45361188
43SGK2231.45361188
44PASK1.44128294
45DYRK21.35519987
46PRKCH1.34384708
47MINK11.31349929
48MAPK131.31149184
49WEE11.30367306
50SGK31.29886573
51STK161.29650799
52MKNK11.28944979
53PRKD21.27965996
54TRIM281.27298351
55STK241.23937703
56FES1.22679342
57NEK61.19022238
58SIK21.13267014
59CDK191.12797969
60JAK31.09238549
61PLK21.09073044
62ATR1.05353985
63TEC1.00700145
64KSR10.98898546
65NLK0.98145840
66PRKCE0.93624616
67CDK50.93059988
68DAPK20.92716714
69PLK40.90933216
70LYN0.90523374
71EEF2K0.88087527
72EPHA40.87085520
73WNK30.85783300
74ERBB30.84468091
75ROCK20.84334994
76BTK0.84185905
77ACVR1B0.82643813
78PAK60.80518487
79PLK10.79699550
80CDK40.76804224
81ERN10.72867492
82SYK0.72517748
83PRPF4B0.71570323
84CDK80.70738353
85CAMK1D0.70362837
86BMPR20.68290214
87NTRK10.67593530
88STK40.67447986
89FGFR20.67327737
90GRK10.67058549
91CAMK10.65785681
92PLK30.65381050
93TNIK0.65167365
94CHEK20.64069002
95RPS6KA40.62603507
96RPS6KA50.62092164
97PKN10.62027441
98PINK10.59666561
99IRAK10.59637826
100PRKCZ0.58356344
101TGFBR10.58081082
102FGR0.57733549
103NME10.57510200
104MAP3K120.56100172
105UHMK10.55748826
106SIK30.54896506
107PDGFRA0.54884898
108AURKB0.54809848
109STK100.54028841
110SGK10.52486317
111MAP2K60.51822748
112DYRK30.51432079
113CHEK10.50975785
114PTK2B0.50357333
115ROCK10.50088371
116CDK30.49526513
117ZAK0.49197067
118NEK90.48855997
119EIF2AK10.48401049
120MAP2K10.45760980
121CSNK2A20.44303045
122AKT20.43823962
123CAMK2A0.42676777
124VRK10.41485592
125FRK0.40661272
126TLK10.40100394
127MAPK80.38990480
128INSR0.38827944
129CDK120.38266028
130CSNK2A10.38191200
131MAPK120.38186367
132PRKCB0.37555141
133MAP3K60.37462454
134PAK30.37377684
135MAPK100.36787383
136MAP3K50.36519487
137PRKACA0.36314761
138IRAK40.35972539
139CSNK1G10.34680217
140PRKDC0.33785834
141MUSK0.33769464
142DAPK10.33627613
143EGFR0.33600789
144SCYL20.32723283
145TYRO30.32000991
146CDK20.31326711
147MATK0.30524628
148CSNK1A10.30037214
149MST1R0.29807606
150ALK0.29402680
151RPS6KA20.29315465
152RIPK40.28165532
153KSR20.27741488
154PRKCG0.27406928
155LATS20.26986049
156GRK50.26751381
157MAPK90.26615176
158AURKA0.26335497
159ATM0.25953936
160BMX0.25835096
161FGFR40.25774998
162RPS6KB10.24915923
163MAP3K10.24677609
164CCNB10.24305322
165PRKCQ0.23768858
166GSK3A0.23750191
167MAPK40.23429879
168AKT10.23355270
169PTK60.22873009
170TIE10.21965206
171MAPK140.21717324
172DYRK1A0.21185752
173GSK3B0.21068247
174PRKG10.20625382
175SRC0.18790836
176INSRR0.18545731
177CDK10.18478154
178TNK20.18289644
179CSNK1E0.17880698

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004305.49947184
2Mismatch repair_Homo sapiens_hsa034304.84369949
3DNA replication_Homo sapiens_hsa030303.98705009
4Nicotine addiction_Homo sapiens_hsa050333.95396524
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.24611762
6GABAergic synapse_Homo sapiens_hsa047273.20720630
7Proteasome_Homo sapiens_hsa030503.01528675
8Homologous recombination_Homo sapiens_hsa034402.99841201
9Synaptic vesicle cycle_Homo sapiens_hsa047212.99530262
10Asthma_Homo sapiens_hsa053102.70727020
11Morphine addiction_Homo sapiens_hsa050322.64887657
12Non-homologous end-joining_Homo sapiens_hsa034502.57343741
13Butanoate metabolism_Homo sapiens_hsa006502.48851825
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40463463
15Primary immunodeficiency_Homo sapiens_hsa053402.37965675
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34179882
17RNA polymerase_Homo sapiens_hsa030202.25329397
18B cell receptor signaling pathway_Homo sapiens_hsa046622.17441908
19Ribosome_Homo sapiens_hsa030102.09579712
20beta-Alanine metabolism_Homo sapiens_hsa004101.93379149
21Systemic lupus erythematosus_Homo sapiens_hsa053221.89145607
22* Serotonergic synapse_Homo sapiens_hsa047261.85422561
23RNA transport_Homo sapiens_hsa030131.85321990
24Allograft rejection_Homo sapiens_hsa053301.82202540
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.81901103
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.77918335
27Autoimmune thyroid disease_Homo sapiens_hsa053201.77460547
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71334872
29Vitamin B6 metabolism_Homo sapiens_hsa007501.70244874
30Dopaminergic synapse_Homo sapiens_hsa047281.68849834
31Spliceosome_Homo sapiens_hsa030401.68282204
32Nucleotide excision repair_Homo sapiens_hsa034201.67040593
33Circadian entrainment_Homo sapiens_hsa047131.66117109
34Glutamatergic synapse_Homo sapiens_hsa047241.56818489
35Selenocompound metabolism_Homo sapiens_hsa004501.50706482
36Olfactory transduction_Homo sapiens_hsa047401.49380288
37Long-term depression_Homo sapiens_hsa047301.49262777
38Graft-versus-host disease_Homo sapiens_hsa053321.48009264
39Axon guidance_Homo sapiens_hsa043601.44623534
40GnRH signaling pathway_Homo sapiens_hsa049121.42600688
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42593515
42RNA degradation_Homo sapiens_hsa030181.41754624
43Insulin secretion_Homo sapiens_hsa049111.39328502
44Type I diabetes mellitus_Homo sapiens_hsa049401.39185919
45ErbB signaling pathway_Homo sapiens_hsa040121.38614819
46Cardiac muscle contraction_Homo sapiens_hsa042601.38380822
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38373610
48Staphylococcus aureus infection_Homo sapiens_hsa051501.38130988
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37440041
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34448172
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33877159
52Antigen processing and presentation_Homo sapiens_hsa046121.32083962
53Cell cycle_Homo sapiens_hsa041101.30321108
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29531182
55Basal transcription factors_Homo sapiens_hsa030221.28151081
56* Taste transduction_Homo sapiens_hsa047421.26888871
57Cholinergic synapse_Homo sapiens_hsa047251.24940083
58Parkinsons disease_Homo sapiens_hsa050121.24718323
59Type II diabetes mellitus_Homo sapiens_hsa049301.22046599
60Long-term potentiation_Homo sapiens_hsa047201.20703635
61Biosynthesis of amino acids_Homo sapiens_hsa012301.19213386
62Cysteine and methionine metabolism_Homo sapiens_hsa002701.19078009
63Choline metabolism in cancer_Homo sapiens_hsa052311.19055450
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.17218539
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16440103
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13634297
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13594376
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12898392
69Colorectal cancer_Homo sapiens_hsa052101.11854841
70Regulation of autophagy_Homo sapiens_hsa041401.07807038
71Amphetamine addiction_Homo sapiens_hsa050311.07244390
72mRNA surveillance pathway_Homo sapiens_hsa030151.06485289
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06355278
74Oxytocin signaling pathway_Homo sapiens_hsa049211.04332223
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02731154
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02081100
77Dilated cardiomyopathy_Homo sapiens_hsa054140.99539471
78Pyrimidine metabolism_Homo sapiens_hsa002400.98889262
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98388985
80Pyruvate metabolism_Homo sapiens_hsa006200.97799011
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97449523
82Phototransduction_Homo sapiens_hsa047440.97301559
83Fanconi anemia pathway_Homo sapiens_hsa034600.97291835
84Epstein-Barr virus infection_Homo sapiens_hsa051690.91516049
85Protein export_Homo sapiens_hsa030600.90791905
86Endometrial cancer_Homo sapiens_hsa052130.90141827
87MAPK signaling pathway_Homo sapiens_hsa040100.88981600
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86172197
89Viral myocarditis_Homo sapiens_hsa054160.85577753
90Calcium signaling pathway_Homo sapiens_hsa040200.84112997
91Wnt signaling pathway_Homo sapiens_hsa043100.83328328
92Salivary secretion_Homo sapiens_hsa049700.81877281
93Propanoate metabolism_Homo sapiens_hsa006400.80723545
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80162787
95Huntingtons disease_Homo sapiens_hsa050160.79450590
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79411733
97Glutathione metabolism_Homo sapiens_hsa004800.78358722
98Renin secretion_Homo sapiens_hsa049240.78008723
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.77883439
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76634203
101Steroid biosynthesis_Homo sapiens_hsa001000.75263228
102Tryptophan metabolism_Homo sapiens_hsa003800.74688826
103Carbon metabolism_Homo sapiens_hsa012000.71944951
104Collecting duct acid secretion_Homo sapiens_hsa049660.71412553
105Vitamin digestion and absorption_Homo sapiens_hsa049770.70364889
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69866167
107Fatty acid elongation_Homo sapiens_hsa000620.69369137
108Melanogenesis_Homo sapiens_hsa049160.69348594
109Cocaine addiction_Homo sapiens_hsa050300.68618393
110Glioma_Homo sapiens_hsa052140.67643326
111Folate biosynthesis_Homo sapiens_hsa007900.66800744
112Purine metabolism_Homo sapiens_hsa002300.65870061
113Hematopoietic cell lineage_Homo sapiens_hsa046400.64692530
114Prolactin signaling pathway_Homo sapiens_hsa049170.64488988
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63982409
116Phenylalanine metabolism_Homo sapiens_hsa003600.63835441
117Gap junction_Homo sapiens_hsa045400.63541074
118Herpes simplex infection_Homo sapiens_hsa051680.62797474
119Ovarian steroidogenesis_Homo sapiens_hsa049130.62206698
120Ras signaling pathway_Homo sapiens_hsa040140.59601886
121Estrogen signaling pathway_Homo sapiens_hsa049150.58345654
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57721696
123Dorso-ventral axis formation_Homo sapiens_hsa043200.56510532
124Rap1 signaling pathway_Homo sapiens_hsa040150.54068676
125Pancreatic secretion_Homo sapiens_hsa049720.52511187
126Renal cell carcinoma_Homo sapiens_hsa052110.52483944
127Pentose phosphate pathway_Homo sapiens_hsa000300.50236684
128Melanoma_Homo sapiens_hsa052180.50222454
129Sphingolipid metabolism_Homo sapiens_hsa006000.50000602
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49565215
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49526275
132Gastric acid secretion_Homo sapiens_hsa049710.45323585
133cAMP signaling pathway_Homo sapiens_hsa040240.43766168
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43662204
135Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42507955
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.41246150
137Influenza A_Homo sapiens_hsa051640.41181977
138Base excision repair_Homo sapiens_hsa034100.39483961
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39386745
140Pancreatic cancer_Homo sapiens_hsa052120.38781247
141HTLV-I infection_Homo sapiens_hsa051660.38050528
142Alcoholism_Homo sapiens_hsa050340.37708906
143Alzheimers disease_Homo sapiens_hsa050100.36555826
144Oocyte meiosis_Homo sapiens_hsa041140.36438561
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35744712
146Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35052689
147cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33750116
148Hippo signaling pathway_Homo sapiens_hsa043900.32667604
149Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31682978
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.31648755
151Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29486533
152Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29287590
153Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28051542
154Metabolic pathways_Homo sapiens_hsa011000.27535445
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27280807
156Rheumatoid arthritis_Homo sapiens_hsa053230.26745346
157Leishmaniasis_Homo sapiens_hsa051400.26513622
158Pathways in cancer_Homo sapiens_hsa052000.25483469
159Viral carcinogenesis_Homo sapiens_hsa052030.25418523
160Vibrio cholerae infection_Homo sapiens_hsa051100.24923583
161Prion diseases_Homo sapiens_hsa050200.24196871
162Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23943857
163Oxidative phosphorylation_Homo sapiens_hsa001900.22215830
164Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.21654051
165Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21541332
166Tight junction_Homo sapiens_hsa045300.21436482
167Tyrosine metabolism_Homo sapiens_hsa003500.20791427
168Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20266850
169Galactose metabolism_Homo sapiens_hsa000520.20211053
170Prostate cancer_Homo sapiens_hsa052150.20016811
171Neurotrophin signaling pathway_Homo sapiens_hsa047220.19408962
172Hepatitis C_Homo sapiens_hsa051600.18101676
173Bile secretion_Homo sapiens_hsa049760.17114015
174One carbon pool by folate_Homo sapiens_hsa006700.15776078
175Arginine and proline metabolism_Homo sapiens_hsa003300.15467766
176NF-kappa B signaling pathway_Homo sapiens_hsa040640.14734939

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