HTR3E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female receptivity (GO:0045924)7.35567738
2bundle of His cell to Purkinje myocyte communication (GO:0086069)6.94490929
3regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)6.63675221
4relaxation of smooth muscle (GO:0044557)6.63404763
5leukotriene metabolic process (GO:0006691)6.59229832
6female mating behavior (GO:0060180)6.18509807
7icosanoid biosynthetic process (GO:0046456)6.09822402
8fatty acid derivative biosynthetic process (GO:1901570)6.09822402
9synaptic transmission, dopaminergic (GO:0001963)5.87835268
10phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)5.85790662
11sensory perception of taste (GO:0050909)5.60409968
12regulation of phospholipase A2 activity (GO:0032429)5.27738520
13cGMP-mediated signaling (GO:0019934)5.26260943
14unsaturated fatty acid biosynthetic process (GO:0006636)5.07429395
15adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.83045444
16signal peptide processing (GO:0006465)4.71624076
17glutathione metabolic process (GO:0006749)4.70244790
18regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.38057485
19endocrine process (GO:0050886)4.38057485
20regulation of systemic arterial blood pressure by hormone (GO:0001990)4.38057485
21negative regulation of complement activation (GO:0045916)4.37272926
22regulation of cholesterol esterification (GO:0010872)4.28765286
23regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.22833641
24regulation of platelet aggregation (GO:0090330)4.16576276
25neuronal action potential (GO:0019228)4.09458649
26cysteine metabolic process (GO:0006534)4.07162487
27positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-4.04718659
28low-density lipoprotein particle remodeling (GO:0034374)3.96819389
29positive regulation of immune response to tumor cell (GO:0002839)3.91089297
30regulation of immune response to tumor cell (GO:0002837)3.91089297
31regulation of response to tumor cell (GO:0002834)3.91089297
32positive regulation of response to tumor cell (GO:0002836)3.91089297
33vesicle targeting (GO:0006903)3.81731378
34negative regulation of protein activation cascade (GO:2000258)3.81407194
35termination of G-protein coupled receptor signaling pathway (GO:0038032)3.74737420
36negative regulation of smooth muscle contraction (GO:0045986)3.66612099
37relaxation of muscle (GO:0090075)3.66324330
38sensory perception of chemical stimulus (GO:0007606)3.59459216
39negative regulation of muscle contraction (GO:0045932)3.52812071
40negative regulation by host of viral transcription (GO:0043922)3.47356112
41negative regulation of humoral immune response (GO:0002921)3.44140732
42negative regulation of interleukin-17 production (GO:0032700)3.38618186
43termination of signal transduction (GO:0023021)3.34037734
44potassium ion import (GO:0010107)3.33363861
45ovulation cycle (GO:0042698)3.25150887
46phosphatidylinositol acyl-chain remodeling (GO:0036149)3.23277446
47icosanoid secretion (GO:0032309)3.20600551
48arachidonic acid secretion (GO:0050482)3.20600551
49positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.18941270
50mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.18941270
51regulation of systemic arterial blood pressure (GO:0003073)3.16253928
52regulation of hydrogen peroxide metabolic process (GO:0010310)3.16193876
53smooth muscle tissue development (GO:0048745)3.12890843
54artery smooth muscle contraction (GO:0014824)3.11023466
55negative regulation of homotypic cell-cell adhesion (GO:0034111)3.09817922
56glutathione derivative metabolic process (GO:1901685)3.08681422
57glutathione derivative biosynthetic process (GO:1901687)3.08681422
58xenobiotic catabolic process (GO:0042178)3.08051804
59phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.07885851
60fatty acid derivative metabolic process (GO:1901568)3.07845754
61icosanoid metabolic process (GO:0006690)3.07845754
62alkaloid metabolic process (GO:0009820)3.03709443
63SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.00652365
64establishment of protein localization to vacuole (GO:0072666)2.97809768
65protein targeting to vacuole (GO:0006623)2.97809768
66protein targeting to lysosome (GO:0006622)2.97809768
67negative regulation of cytosolic calcium ion concentration (GO:0051481)2.97542742
68multicellular organismal reproductive behavior (GO:0033057)2.95073179
69sodium ion transmembrane transport (GO:0035725)2.94263637
70phosphatidylserine acyl-chain remodeling (GO:0036150)2.92287342
71respiratory tube development (GO:0030323)2.92112642
72negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91812599
73early endosome to late endosome transport (GO:0045022)2.91147384
74outer ear morphogenesis (GO:0042473)2.90622931
75negative regulation of smooth muscle cell differentiation (GO:0051151)2.89525578
76neural tube formation (GO:0001841)2.88762004
77mitochondrion distribution (GO:0048311)2.87086569
78glutathione biosynthetic process (GO:0006750)2.86782047
79peptide catabolic process (GO:0043171)2.86524121
80photoreceptor cell maintenance (GO:0045494)2.84583635
81positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.83926753
82regulation of Rac protein signal transduction (GO:0035020)2.81395559
83unsaturated fatty acid metabolic process (GO:0033559)2.80161750
84peptide metabolic process (GO:0006518)2.79600848
85peptide biosynthetic process (GO:0043043)2.79153801
86long term synaptic depression (GO:0060292)2.77276181
87negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.76592878
88positive regulation of response to biotic stimulus (GO:0002833)2.76003658
89tonic smooth muscle contraction (GO:0014820)2.73295842
90fatty acid biosynthetic process (GO:0006633)2.73214459
91regulation of renal sodium excretion (GO:0035813)2.68868264
92cytokine biosynthetic process (GO:0042089)2.64821296
93phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200)2.64685070
94regulation of RIG-I signaling pathway (GO:0039535)2.63057458
95retinal cone cell development (GO:0046549)2.62852432
96positive regulation of catenin import into nucleus (GO:0035413)2.60980863
97cardiolipin metabolic process (GO:0032048)2.57865858
98phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.53401774
99nonribosomal peptide biosynthetic process (GO:0019184)2.52885139
100leukotriene biosynthetic process (GO:0019370)10.0405986

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human3.44393085
2CTBP2_25329375_ChIP-Seq_LNCAP_Human2.95640524
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.83720357
4GBX2_23144817_ChIP-Seq_PC3_Human2.65922120
5VDR_22108803_ChIP-Seq_LS180_Human2.53610034
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.45686843
7PIAS1_25552417_ChIP-Seq_VCAP_Human2.41314566
8TAF15_26573619_Chip-Seq_HEK293_Human2.31435235
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18841590
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18811913
11P300_19829295_ChIP-Seq_ESCs_Human2.14850885
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10927996
13IRF1_19129219_ChIP-ChIP_H3396_Human2.09262952
14FUS_26573619_Chip-Seq_HEK293_Human2.02698120
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02686311
16ER_23166858_ChIP-Seq_MCF-7_Human2.00648385
17EWS_26573619_Chip-Seq_HEK293_Human1.97637043
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.96364040
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79306245
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74942441
21SCL_19346495_ChIP-Seq_HPC-7_Human1.70769456
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.69970142
23NR3C1_21868756_ChIP-Seq_MCF10A_Human1.69939675
24SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.68962430
25SMAD3_21741376_ChIP-Seq_EPCs_Human1.58780096
26AR_25329375_ChIP-Seq_VCAP_Human1.57451898
27PRDM14_20953172_ChIP-Seq_ESCs_Human1.56113229
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53150004
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51154365
30SMAD4_21741376_ChIP-Seq_EPCs_Human1.50888738
31ZNF274_21170338_ChIP-Seq_K562_Hela1.49594992
32RNF2_27304074_Chip-Seq_NSC_Mouse1.48889064
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47939901
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44851310
35EZH2_22144423_ChIP-Seq_EOC_Human1.43699181
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42792589
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42792589
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38810052
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37929225
40TP53_22573176_ChIP-Seq_HFKS_Human1.37821341
41STAT3_23295773_ChIP-Seq_U87_Human1.37760597
42NANOG_19829295_ChIP-Seq_ESCs_Human1.36472272
43SOX2_19829295_ChIP-Seq_ESCs_Human1.36472272
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35977537
45SMAD4_21799915_ChIP-Seq_A2780_Human1.32609929
46BCAT_22108803_ChIP-Seq_LS180_Human1.30469334
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.28479927
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28000285
49RUNX2_22187159_ChIP-Seq_PCA_Human1.27696628
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27085340
51* CDX2_22108803_ChIP-Seq_LS180_Human1.26046706
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.25044420
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24716813
54REST_21632747_ChIP-Seq_MESCs_Mouse1.24329989
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21462371
56FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20886759
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20291604
58CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.20034765
59AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19217756
60AR_21572438_ChIP-Seq_LNCaP_Human1.18920461
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.17055258
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16784672
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16639624
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16332461
65TCF4_22108803_ChIP-Seq_LS180_Human1.14504255
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14019818
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.13223120
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12886189
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12639830
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11974999
71SMRT_27268052_Chip-Seq_Bcells_Human1.11603217
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.11541349
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09351032
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09195706
75* TP63_23658742_ChIP-Seq_EP156T_Human1.08875057
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.08798959
77TCF4_18268006_ChIP-ChIP_LS174T_Human1.06726274
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06688065
79JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06490990
80TBL1_22424771_ChIP-Seq_293T_Human1.06156184
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05858633
82STAT1_20625510_ChIP-Seq_HELA_Human1.05793969
83AR_20517297_ChIP-Seq_VCAP_Human1.04920943
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02994031
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02990664
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02760265
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02244181
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01989348
89TCF4_23295773_ChIP-Seq_U87_Human0.99821731
90TP53_18474530_ChIP-ChIP_U2OS_Human0.99727394
91FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99308574
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.98253304
93JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97738739
94PHF8_20622853_ChIP-Seq_HELA_Human0.97315306
95CBP_20019798_ChIP-Seq_JUKART_Human0.96984921
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96984921
97P53_22387025_ChIP-Seq_ESCs_Mouse0.95046644
98OCT1_27270436_Chip-Seq_PROSTATE_Human0.93894040
99CBX2_27304074_Chip-Seq_ESCs_Mouse0.93531248
100CJUN_26792858_Chip-Seq_BT549_Human0.92078853

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol5.60293733
2MP0001986_abnormal_taste_sensitivity5.50050857
3MP0004858_abnormal_nervous_system5.26361044
4MP0005423_abnormal_somatic_nervous4.91315903
5MP0002736_abnormal_nociception_after4.56546063
6MP0000569_abnormal_digit_pigmentation3.83603551
7MP0001968_abnormal_touch/_nociception3.51192677
8MP0002909_abnormal_adrenal_gland2.69998922
9MP0009046_muscle_twitch2.50194112
10MP0002163_abnormal_gland_morphology2.10446861
11MP0006276_abnormal_autonomic_nervous2.08729771
12MP0005379_endocrine/exocrine_gland_phen2.08260092
13MP0005551_abnormal_eye_electrophysiolog2.07618183
14MP0002138_abnormal_hepatobiliary_system2.07071105
15MP0009697_abnormal_copulation1.93435608
16MP0003879_abnormal_hair_cell1.86991097
17MP0010368_abnormal_lymphatic_system1.81343859
18MP0003787_abnormal_imprinting1.71849225
19MP0000613_abnormal_salivary_gland1.70920512
20MP0001502_abnormal_circadian_rhythm1.70549020
21MP0002733_abnormal_thermal_nociception1.70186812
22MP0001501_abnormal_sleep_pattern1.63596161
23MP0004808_abnormal_hematopoietic_stem1.62414829
24MP0005174_abnormal_tail_pigmentation1.60984097
25MP0002638_abnormal_pupillary_reflex1.58773399
26MP0001664_abnormal_digestion1.54884280
27MP0005220_abnormal_exocrine_pancreas1.52595334
28MP0008995_early_reproductive_senescence1.51421026
29MP0002822_catalepsy1.51059760
30MP0000230_abnormal_systemic_arterial1.48824336
31MP0002102_abnormal_ear_morphology1.48664774
32MP0003183_abnormal_peptide_metabolism1.47022178
33MP0001970_abnormal_pain_threshold1.44149924
34MP0000631_abnormal_neuroendocrine_gland1.40435074
35MP0002089_abnormal_postnatal_growth/wei1.37408612
36MP0005310_abnormal_salivary_gland1.35923468
37MP0005253_abnormal_eye_physiology1.31032992
38MP0005595_abnormal_vascular_smooth1.29743102
39MP0003123_paternal_imprinting1.25330142
40MP0006072_abnormal_retinal_apoptosis1.24909880
41MP0002148_abnormal_hypersensitivity_rea1.23579235
42MP0003195_calcinosis1.22478024
43MP0004036_abnormal_muscle_relaxation1.11942215
44MP0005397_hematopoietic_system_phenotyp1.07385637
45MP0001545_abnormal_hematopoietic_system1.07385637
46MP0005464_abnormal_platelet_physiology1.06708684
47MP0001984_abnormal_olfaction1.06500114
48MP0000026_abnormal_inner_ear1.06373856
49MP0004084_abnormal_cardiac_muscle1.04547813
50MP0005365_abnormal_bile_salt1.00362791
51MP0002229_neurodegeneration0.98945629
52MP0001485_abnormal_pinna_reflex0.97411547
53MP0000013_abnormal_adipose_tissue0.97210266
54MP0002272_abnormal_nervous_system0.95078239
55MP0003880_abnormal_central_pattern0.94367027
56MP0002254_reproductive_system_inflammat0.92666160
57MP0002095_abnormal_skin_pigmentation0.90153007
58MP0006082_CNS_inflammation0.88987355
59MP0002693_abnormal_pancreas_physiology0.84384946
60MP0004142_abnormal_muscle_tone0.83531232
61MP0008872_abnormal_physiological_respon0.83348328
62MP0000538_abnormal_urinary_bladder0.82856979
63MP0004270_analgesia0.79323003
64MP0005410_abnormal_fertilization0.78131880
65MP0001851_eye_inflammation0.76547590
66MP0002572_abnormal_emotion/affect_behav0.76182087
67MP0000383_abnormal_hair_follicle0.75474536
68MP0005332_abnormal_amino_acid0.72877166
69MP0005451_abnormal_body_composition0.72781561
70MP0002405_respiratory_system_inflammati0.72151132
71MP0008877_abnormal_DNA_methylation0.69329678
72MP0003329_amyloid_beta_deposits0.68231899
73MP0003638_abnormal_response/metabolism_0.67603364
74MP0009764_decreased_sensitivity_to0.67469488
75MP0000015_abnormal_ear_pigmentation0.67025979
76MP0004885_abnormal_endolymph0.66377452
77MP0003045_fibrosis0.65853764
78MP0002067_abnormal_sensory_capabilities0.64913489
79MP0004484_altered_response_of0.63863521
80MP0000516_abnormal_urinary_system0.63391298
81MP0005367_renal/urinary_system_phenotyp0.63391298
82MP0001346_abnormal_lacrimal_gland0.63107705
83MP0001764_abnormal_homeostasis0.63013215
84MP0001348_abnormal_lacrimal_gland0.61867606
85MP0008569_lethality_at_weaning0.60428409
86MP0001324_abnormal_eye_pigmentation0.60396715
87MP0000685_abnormal_immune_system0.60240624
88MP0009643_abnormal_urine_homeostasis0.60162108
89MP0003950_abnormal_plasma_membrane0.57625675
90MP0004133_heterotaxia0.57453753
91MP0005085_abnormal_gallbladder_physiolo0.56987306
92MP0008004_abnormal_stomach_pH0.56722593
93MP0008775_abnormal_heart_ventricle0.56491473
94MP0009745_abnormal_behavioral_response0.56122399
95MP0001661_extended_life_span0.56054019
96MP0002752_abnormal_somatic_nervous0.55773412
97MP0002734_abnormal_mechanical_nocicepti0.55313260
98MP0003632_abnormal_nervous_system0.55279528
99MP0001944_abnormal_pancreas_morphology0.55118924
100MP0010386_abnormal_urinary_bladder0.52623000

Predicted human phenotypes

RankGene SetZ-score
1Potter facies (HP:0002009)5.23015107
2Facial shape deformation (HP:0011334)5.23015107
3True hermaphroditism (HP:0010459)5.08927321
4Increased neuronal autofluorescent lipopigment (HP:0002074)4.54040372
5Pancreatic fibrosis (HP:0100732)4.27962340
6Keratoconjunctivitis (HP:0001096)4.16957937
7Pancreatic cysts (HP:0001737)4.12514755
8Hemiparesis (HP:0001269)3.95370200
9Widely patent fontanelles and sutures (HP:0004492)3.90033690
10Keratoconjunctivitis sicca (HP:0001097)3.85936311
11Increased cerebral lipofuscin (HP:0011813)3.78556291
12Abolished electroretinogram (ERG) (HP:0000550)3.59559504
13Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.49875788
14Abnormality of binocular vision (HP:0011514)3.47742308
15Diplopia (HP:0000651)3.47742308
16Abnormal biliary tract physiology (HP:0012439)3.45464091
17Bile duct proliferation (HP:0001408)3.45464091
18Congenital stationary night blindness (HP:0007642)3.44698572
19Progressive visual loss (HP:0000529)3.29390183
20Nephronophthisis (HP:0000090)3.25355831
21Abnormality of midbrain morphology (HP:0002418)3.20941454
22Molar tooth sign on MRI (HP:0002419)3.20941454
23Global brain atrophy (HP:0002283)3.15756058
24Absent/shortened dynein arms (HP:0200106)3.14503721
25Dynein arm defect of respiratory motile cilia (HP:0012255)3.14503721
26Febrile seizures (HP:0002373)3.12635994
27Abnormal urine output (HP:0012590)3.10543216
28Cystic liver disease (HP:0006706)3.05443130
29Abnormality of renal excretion (HP:0011036)3.03331294
30Vacuolated lymphocytes (HP:0001922)2.99344823
31Decreased circulating renin level (HP:0003351)2.95379595
32Aplasia/Hypoplasia of the spleen (HP:0010451)2.91755705
33Pigmentary retinal degeneration (HP:0001146)2.86015408
34Male pseudohermaphroditism (HP:0000037)2.82562733
35Congenital sensorineural hearing impairment (HP:0008527)2.81004987
36Large for gestational age (HP:0001520)2.74712717
37Congenital, generalized hypertrichosis (HP:0004540)2.70920577
38Abnormality of the renal collecting system (HP:0004742)2.67457573
39Asplenia (HP:0001746)2.67441985
40Furrowed tongue (HP:0000221)2.64249432
41Type 2 muscle fiber atrophy (HP:0003554)2.62202100
42Duplicated collecting system (HP:0000081)2.61093928
43Hypercortisolism (HP:0001578)2.52672151
44Decreased central vision (HP:0007663)2.48195119
45Attenuation of retinal blood vessels (HP:0007843)2.43994414
46Abnormality of the renal medulla (HP:0100957)2.42668673
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40905407
48Hypoplastic ischia (HP:0003175)2.36432502
49Limb dystonia (HP:0002451)2.31715245
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.29828896
51Aplasia/Hypoplasia of the tongue (HP:0010295)2.29192714
52Cerebellar dysplasia (HP:0007033)2.27938715
53Ketoacidosis (HP:0001993)2.24891334
54Sex reversal (HP:0012245)2.22734666
55Abnormal sex determination (HP:0012244)2.22734666
56Anencephaly (HP:0002323)2.22350816
57Clumsiness (HP:0002312)2.14589905
58Hyperactive renin-angiotensin system (HP:0000841)2.13975038
59Constricted visual fields (HP:0001133)2.13846342
60Congenital hepatic fibrosis (HP:0002612)2.11762925
61Cardiomegaly (HP:0001640)2.10502888
62Abnormality of pyrimidine metabolism (HP:0004353)2.09383625
63Abnormal ciliary motility (HP:0012262)2.09328598
64Abnormality of DNA repair (HP:0003254)2.06417651
65Neurofibrillary tangles (HP:0002185)2.06104125
66Muscle fiber atrophy (HP:0100295)2.04886621
67Keratitis (HP:0000491)2.04402649
68Reticulocytopenia (HP:0001896)2.04108460
69Chronic mucocutaneous candidiasis (HP:0002728)2.04054227
70Recurrent cutaneous fungal infections (HP:0011370)2.04054227
71Oligohydramnios (HP:0001562)2.02974274
72Pancreatic islet-cell hyperplasia (HP:0004510)2.00781679
73Confusion (HP:0001289)2.00198430
74Nonprogressive disorder (HP:0003680)1.99862600
75Optic nerve coloboma (HP:0000588)1.98548049
76Adrenal overactivity (HP:0002717)1.95514932
77Vascular calcification (HP:0004934)1.95507143
78Bony spicule pigmentary retinopathy (HP:0007737)1.94855561
79Visual hallucinations (HP:0002367)1.93346431
80Abnormality of the anterior chamber (HP:0000593)1.92082571
81Tubular atrophy (HP:0000092)1.90041496
82Epiphyseal dysplasia (HP:0002656)1.89099171
83Truncal obesity (HP:0001956)1.88074863
84Abnormality of the ischium (HP:0003174)1.87207934
85Occipital encephalocele (HP:0002085)1.87198134
86Amelogenesis imperfecta (HP:0000705)1.86789099
87Impaired smooth pursuit (HP:0007772)1.80901397
88Hypotension (HP:0002615)1.80197521
89Wide cranial sutures (HP:0010537)1.79792930
90Azoospermia (HP:0000027)1.79282232
91Postaxial foot polydactyly (HP:0001830)1.78527008
92Dysautonomia (HP:0002459)1.77260044
93Tinnitus (HP:0000360)1.74868781
94Abnormal rod and cone electroretinograms (HP:0008323)1.73497959
95Abnormality of renin-angiotensin system (HP:0000847)1.73135258
96Sclerocornea (HP:0000647)1.72621539
97Chronic bronchitis (HP:0004469)1.71433814
98Abnormal respiratory epithelium morphology (HP:0012253)1.69564558
99Abnormal respiratory motile cilium morphology (HP:0005938)1.69564558
100Absent phalangeal crease (HP:0006109)1.66907623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TEC5.94395624
2ITK4.10684883
3FRK3.74607624
4GRK13.35073722
5PIK3CG3.09157569
6MKNK12.75098337
7ADRBK22.70918551
8PINK12.70824255
9PBK2.63380392
10BTK2.52721511
11MKNK22.25195157
12PRKG22.24519862
13YES12.05209300
14ACVR1B1.93021187
15MAP3K41.78651490
16STK38L1.65249586
17PTK21.63654333
18LATS11.53831083
19DYRK1A1.48783481
20BLK1.48190728
21FGFR31.45711448
22NUAK11.44519240
23DAPK21.38849653
24PNCK1.38661575
25MAP2K11.30067708
26PTK2B1.29660056
27NTRK31.29115948
28PLK21.24211862
29VRK11.23957558
30INSRR1.21004677
31DDR21.15065443
32TRPM71.14021908
33IRAK11.12908215
34PRKCE1.12517511
35STK241.01000995
36MAPK151.00625102
37MAPKAPK50.98966930
38MAP3K20.98024698
39MAP2K20.91977016
40MOS0.90247258
41GRK60.89185463
42CDK30.88656424
43SYK0.88403290
44ERBB30.83987934
45DYRK30.83097739
46CAMKK20.76790276
47MAP3K60.76681609
48MUSK0.75635005
49TAOK30.74598604
50IGF1R0.74316583
51MAP2K70.73347713
52MAP2K60.70259596
53STK30.69275512
54RPS6KB20.69244182
55ADRBK10.69142681
56PRKG10.68899353
57PRKD30.66134219
58GRK50.63321775
59PAK30.62854329
60UHMK10.62803174
61CAMK2A0.60710414
62IRAK40.58462072
63JAK30.55499649
64INSR0.54884006
65IKBKE0.54466300
66MAP3K10.54381645
67GRK70.53889283
68CSK0.53858272
69BRSK20.53724194
70TAOK10.53267680
71TXK0.52689782
72MAP3K100.52247159
73TBK10.52075101
74ZAK0.50728697
75MAPK110.50593115
76SGK20.50242168
77MAPKAPK20.50048641
78CAMK2D0.49242662
79PLK30.48763598
80BMPR1B0.47279546
81RPS6KA60.45353748
82PRKACA0.42897959
83KIT0.41555525
84PRKCQ0.41279567
85CAMK2G0.41230940
86PRKACG0.38689597
87RPS6KA50.38020302
88ERBB40.37105662
89PRKACB0.36657408
90CSNK1A10.36197577
91RPS6KC10.34911537
92RPS6KL10.34911537
93SIK20.34588039
94AKT30.34090874
95HCK0.33881054
96LYN0.33833121
97RIPK10.33715917
98DYRK20.33590678
99PRKCA0.32361356
100PRKCG0.31644764

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.08407065
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.09693312
3* Taste transduction_Homo sapiens_hsa047422.96417332
4Linoleic acid metabolism_Homo sapiens_hsa005912.61608591
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.60891178
6Renin-angiotensin system_Homo sapiens_hsa046142.47471879
7Ether lipid metabolism_Homo sapiens_hsa005652.37885792
8Tryptophan metabolism_Homo sapiens_hsa003802.35918858
9Arachidonic acid metabolism_Homo sapiens_hsa005902.26472099
10Renin secretion_Homo sapiens_hsa049242.20339158
11Olfactory transduction_Homo sapiens_hsa047401.97342967
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.95003197
13Histidine metabolism_Homo sapiens_hsa003401.94866895
14Selenocompound metabolism_Homo sapiens_hsa004501.77209670
15Vascular smooth muscle contraction_Homo sapiens_hsa042701.77177364
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.64167336
17Phototransduction_Homo sapiens_hsa047441.63883721
18Collecting duct acid secretion_Homo sapiens_hsa049661.61547762
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.57449270
20Glycerolipid metabolism_Homo sapiens_hsa005611.51511311
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49086303
22Long-term depression_Homo sapiens_hsa047301.43687481
23Nitrogen metabolism_Homo sapiens_hsa009101.42209391
24Platelet activation_Homo sapiens_hsa046111.37998870
25cGMP-PKG signaling pathway_Homo sapiens_hsa040221.37197568
26Circadian entrainment_Homo sapiens_hsa047131.36212009
27beta-Alanine metabolism_Homo sapiens_hsa004101.31192270
28Glutamatergic synapse_Homo sapiens_hsa047241.28949569
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.26415610
30Calcium signaling pathway_Homo sapiens_hsa040201.26162478
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22218113
32Morphine addiction_Homo sapiens_hsa050321.21307685
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20187235
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.18189482
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17187331
36Salivary secretion_Homo sapiens_hsa049701.13694434
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12633790
38Glutathione metabolism_Homo sapiens_hsa004801.08572045
39Chemical carcinogenesis_Homo sapiens_hsa052041.06116558
40* Serotonergic synapse_Homo sapiens_hsa047261.03015423
41Ovarian steroidogenesis_Homo sapiens_hsa049131.02041562
42Cholinergic synapse_Homo sapiens_hsa047251.00530999
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.97560650
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.97000044
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94979094
46African trypanosomiasis_Homo sapiens_hsa051430.93684386
47Amphetamine addiction_Homo sapiens_hsa050310.92947505
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92828982
49Choline metabolism in cancer_Homo sapiens_hsa052310.90455880
50ABC transporters_Homo sapiens_hsa020100.88688574
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87229608
52GABAergic synapse_Homo sapiens_hsa047270.86323990
53Insulin secretion_Homo sapiens_hsa049110.84299487
54Cocaine addiction_Homo sapiens_hsa050300.83237167
55Nicotine addiction_Homo sapiens_hsa050330.82845035
56Circadian rhythm_Homo sapiens_hsa047100.82548975
57Pancreatic secretion_Homo sapiens_hsa049720.80565914
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79681727
59Butanoate metabolism_Homo sapiens_hsa006500.79236389
60cAMP signaling pathway_Homo sapiens_hsa040240.79033381
61Fatty acid degradation_Homo sapiens_hsa000710.79007077
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70615771
63Type I diabetes mellitus_Homo sapiens_hsa049400.69464395
64Bile secretion_Homo sapiens_hsa049760.68949008
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68396832
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65122222
67Type II diabetes mellitus_Homo sapiens_hsa049300.63919109
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60696687
69Propanoate metabolism_Homo sapiens_hsa006400.60577754
70Sulfur relay system_Homo sapiens_hsa041220.57992360
71Retinol metabolism_Homo sapiens_hsa008300.56310810
72Estrogen signaling pathway_Homo sapiens_hsa049150.53133512
73Vitamin digestion and absorption_Homo sapiens_hsa049770.48003874
74Dopaminergic synapse_Homo sapiens_hsa047280.46953288
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46617408
76Thyroid hormone synthesis_Homo sapiens_hsa049180.42513842
77Lysine degradation_Homo sapiens_hsa003100.42156057
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41765842
79Sphingolipid metabolism_Homo sapiens_hsa006000.40140278
80Allograft rejection_Homo sapiens_hsa053300.38529599
81Mineral absorption_Homo sapiens_hsa049780.37366852
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37330084
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36235644
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36161512
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.35899489
86Gap junction_Homo sapiens_hsa045400.34125609
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33647538
88Oxytocin signaling pathway_Homo sapiens_hsa049210.33179132
89Fat digestion and absorption_Homo sapiens_hsa049750.32976671
90Hedgehog signaling pathway_Homo sapiens_hsa043400.30015669
91Tuberculosis_Homo sapiens_hsa051520.29129702
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28056763
93Legionellosis_Homo sapiens_hsa051340.27139103
94Inositol phosphate metabolism_Homo sapiens_hsa005620.26404254
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26112119
96Gastric acid secretion_Homo sapiens_hsa049710.24656152
97Peroxisome_Homo sapiens_hsa041460.24200735
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23321020
99Arginine and proline metabolism_Homo sapiens_hsa003300.22571634
100Caffeine metabolism_Homo sapiens_hsa002320.22453324

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