HTR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-8 production (GO:0032717)7.91906110
2positive regulation of osteoblast proliferation (GO:0033690)7.47522595
3positive regulation of hair follicle development (GO:0051798)7.22668626
4positive regulation of hair cycle (GO:0042635)7.22668626
5angiogenesis involved in wound healing (GO:0060055)6.87433233
6regulation of Cdc42 GTPase activity (GO:0043088)6.59457458
7interferon-gamma production (GO:0032609)6.11176937
8regulation of short-term neuronal synaptic plasticity (GO:0048172)6.07204257
9negative regulation of calcium ion transport into cytosol (GO:0010523)6.03353528
10negative regulation of circadian rhythm (GO:0042754)6.00783771
11ionotropic glutamate receptor signaling pathway (GO:0035235)5.99573234
12killing of cells of other organism (GO:0031640)5.67833283
13disruption of cells of other organism (GO:0044364)5.67833283
14protein K48-linked deubiquitination (GO:0071108)5.65004966
15sulfation (GO:0051923)5.53194688
16omega-hydroxylase P450 pathway (GO:0097267)5.50253676
17activated T cell proliferation (GO:0050798)5.49132612
18hematopoietic stem cell proliferation (GO:0071425)5.47858705
19vocalization behavior (GO:0071625)5.46998357
20protein K63-linked deubiquitination (GO:0070536)5.45372178
21lymphangiogenesis (GO:0001946)5.33369447
22synaptic transmission, glutamatergic (GO:0035249)5.20640207
23glycoprotein catabolic process (GO:0006516)5.18389506
24glutamate receptor signaling pathway (GO:0007215)5.14516261
25thyroid hormone metabolic process (GO:0042403)5.04829223
26carnitine transmembrane transport (GO:1902603)5.01810135
27homocysteine metabolic process (GO:0050667)5.00817580
28flavonoid metabolic process (GO:0009812)4.90144267
29transmission of nerve impulse (GO:0019226)4.84688221
30synaptic vesicle maturation (GO:0016188)4.79657058
31defense response to fungus (GO:0050832)4.79568534
32proline transport (GO:0015824)4.77804422
33neuron-neuron synaptic transmission (GO:0007270)4.77182238
34amino-acid betaine transport (GO:0015838)4.75060358
35carnitine transport (GO:0015879)4.75060358
36lipid translocation (GO:0034204)4.73414431
37phospholipid translocation (GO:0045332)4.73414431
38regulation of hair follicle development (GO:0051797)4.70457047
39negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.66602853
40behavioral fear response (GO:0001662)4.66510297
41behavioral defense response (GO:0002209)4.66510297
42neuron cell-cell adhesion (GO:0007158)4.63448119
43protein localization to synapse (GO:0035418)4.61879477
44mucosal immune response (GO:0002385)4.60904059
45cysteine metabolic process (GO:0006534)4.55107580
46filopodium assembly (GO:0046847)4.53872797
47glycerophospholipid catabolic process (GO:0046475)4.51160324
48carnitine metabolic process (GO:0009437)4.47588648
49regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.42705844
50neuron recognition (GO:0008038)4.38983442
51cerebellar Purkinje cell layer development (GO:0021680)4.37019740
52granulocyte differentiation (GO:0030851)4.36820073
53gamma-aminobutyric acid signaling pathway (GO:0007214)4.33205683
54positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.30674140
55regulation of glutamate receptor signaling pathway (GO:1900449)4.25845231
56organ or tissue specific immune response (GO:0002251)4.21266688
57regulation of neuronal synaptic plasticity (GO:0048168)4.17794922
58gonadal mesoderm development (GO:0007506)4.12551845
59fear response (GO:0042596)4.12152898
60negative regulation of hormone biosynthetic process (GO:0032353)4.11490486
61purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.10477920
623-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.10477920
63cellular potassium ion homeostasis (GO:0030007)4.03777164
64positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.03109211
65fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.99900746
66organic cation transport (GO:0015695)3.99822937
67righting reflex (GO:0060013)3.95836124
68cell communication by electrical coupling (GO:0010644)3.94729477
69exploration behavior (GO:0035640)3.87350490
70low-density lipoprotein particle remodeling (GO:0034374)3.87010367
71negative regulation of hormone metabolic process (GO:0032351)3.86168910
72long-term memory (GO:0007616)3.82372709
73negative regulation of metanephros development (GO:0072217)3.81020786
74regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.79277219
75regulation of long-term neuronal synaptic plasticity (GO:0048169)3.77248457
76regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.72901143
77synaptic vesicle exocytosis (GO:0016079)3.71562631
78positive regulation of synapse maturation (GO:0090129)3.70648388
79axonal fasciculation (GO:0007413)3.70258820
80phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.67709104
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.65835359
82circadian sleep/wake cycle process (GO:0022410)3.64558439
83G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.62204333
84response to histamine (GO:0034776)3.61616866
85paraxial mesoderm development (GO:0048339)3.60236472
86phosphatidylinositol acyl-chain remodeling (GO:0036149)3.59645176
87quaternary ammonium group transport (GO:0015697)3.58711510
88regulation of sarcomere organization (GO:0060297)3.58309391
89neuronal action potential propagation (GO:0019227)3.58297599
90triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.58258263
91central nervous system projection neuron axonogenesis (GO:0021952)3.58204828
92regulation of excitatory postsynaptic membrane potential (GO:0060079)3.52515362
93gamma-aminobutyric acid transport (GO:0015812)3.52291952
94membrane depolarization during action potential (GO:0086010)3.51847333
95reflex (GO:0060004)3.51433599
96phosphatidylserine acyl-chain remodeling (GO:0036150)3.49043128
97regulation of hair cycle (GO:0042634)3.48040299
98regulation of synaptic transmission, glutamatergic (GO:0051966)3.47232413
99postsynaptic membrane organization (GO:0001941)3.47075930
100amino-acid betaine metabolic process (GO:0006577)3.46333997
101central nervous system myelination (GO:0022010)3.46224586
102axon ensheathment in central nervous system (GO:0032291)3.46224586
103cell killing (GO:0001906)3.45175266
104negative regulation of synaptic transmission, GABAergic (GO:0032229)3.44246946
105vesicle transport along microtubule (GO:0047496)3.43497633
106regulation of dendritic spine morphogenesis (GO:0061001)3.43421866
107positive regulation of cAMP-mediated signaling (GO:0043950)3.43167581
108detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.42957179
109indole-containing compound catabolic process (GO:0042436)3.40881825
110indolalkylamine catabolic process (GO:0046218)3.40881825
111tryptophan catabolic process (GO:0006569)3.40881825
112regulation of steroid hormone biosynthetic process (GO:0090030)3.40793511
113neurotransmitter-gated ion channel clustering (GO:0072578)3.39258620
114angiotensin maturation (GO:0002003)3.38699173
115heparan sulfate proteoglycan metabolic process (GO:0030201)3.38682669
116regulation of synaptic plasticity (GO:0048167)3.38556867
117positive regulation of catecholamine secretion (GO:0033605)3.33836278
118locomotory exploration behavior (GO:0035641)3.33795265
119sex differentiation (GO:0007548)3.31641232
120androgen biosynthetic process (GO:0006702)3.31059233
121regulation of dopamine metabolic process (GO:0042053)3.31008392
122regulation of catecholamine metabolic process (GO:0042069)3.31008392
123regulation of postsynaptic membrane potential (GO:0060078)3.30952502
124positive regulation of epidermis development (GO:0045684)3.30527510
125regulation of membrane lipid distribution (GO:0097035)3.28752017
126presynaptic membrane assembly (GO:0097105)3.28236423
127glutamate secretion (GO:0014047)3.28199131
128cilium or flagellum-dependent cell motility (GO:0001539)3.28166763
129G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.24553468
130response to fungus (GO:0009620)3.24279219
131cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.24181342
132positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.24150192
133long-term synaptic potentiation (GO:0060291)3.23670247
134positive regulation of synaptic transmission, GABAergic (GO:0032230)3.22816900
135cellular sodium ion homeostasis (GO:0006883)3.21987085
136regulation of B cell receptor signaling pathway (GO:0050855)3.21075369
137membrane depolarization (GO:0051899)3.16380869
138startle response (GO:0001964)3.14590918
139membrane hyperpolarization (GO:0060081)3.11727638
140calcium-mediated signaling using intracellular calcium source (GO:0035584)3.11129150
141neurotransmitter secretion (GO:0007269)3.10559898
142glycosphingolipid biosynthetic process (GO:0006688)3.10290396
143digestion (GO:0007586)3.10243587
144presynaptic membrane organization (GO:0097090)3.09268302
145synaptic vesicle docking involved in exocytosis (GO:0016081)3.09201808
146synaptic vesicle endocytosis (GO:0048488)3.08917189
147cerebellar Purkinje cell differentiation (GO:0021702)3.07853032
148multicellular organismal signaling (GO:0035637)3.07474454
149neuronal ion channel clustering (GO:0045161)3.06134030
150rRNA catabolic process (GO:0016075)3.05394867
151striated muscle atrophy (GO:0014891)3.02764716
152neuromuscular synaptic transmission (GO:0007274)3.01448516
153regulation of dopamine secretion (GO:0014059)3.01127756
154striatum development (GO:0021756)3.00203634
155regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00091684
156* synaptic transmission (GO:0007268)2.98621373
157learning (GO:0007612)2.97408577
158establishment of protein localization to Golgi (GO:0072600)2.97226441
159regulation of osteoblast proliferation (GO:0033688)2.96702006
160adult walking behavior (GO:0007628)2.96544559
161protein sumoylation (GO:0016925)2.96410557
162sodium ion export (GO:0071436)2.95859243
163endothelial cell proliferation (GO:0001935)2.94676569
164regulation of integrin-mediated signaling pathway (GO:2001044)2.94658439
165regulation of synaptic vesicle exocytosis (GO:2000300)2.94126173
166dendrite morphogenesis (GO:0048813)2.93397017
167layer formation in cerebral cortex (GO:0021819)2.92571219
168behavioral response to nicotine (GO:0035095)2.92076496
169regulation of synaptic vesicle transport (GO:1902803)2.91991977
170cellular ketone body metabolic process (GO:0046950)2.91531904
171positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.91405116
172positive regulation of dendritic spine morphogenesis (GO:0061003)2.89025832
173negative regulation of mast cell activation (GO:0033004)2.88674031
174skeletal muscle adaptation (GO:0043501)2.88672739
175organelle transport along microtubule (GO:0072384)2.87108079
176innervation (GO:0060384)2.86910104
177regulation of female receptivity (GO:0045924)2.86565526
178regulation of dendritic spine development (GO:0060998)2.86442238
179negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.85590584
180serotonin metabolic process (GO:0042428)2.84158475
181neurotransmitter transport (GO:0006836)2.84037142
182positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.83252205
183skin development (GO:0043588)2.82826812
184negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.82776017
185positive regulation of vasculogenesis (GO:2001214)2.82676650
186cell migration in hindbrain (GO:0021535)2.82462156
187regulation of synapse structural plasticity (GO:0051823)2.81847535
188regulation of synaptic transmission (GO:0050804)2.81774598
189nucleoside bisphosphate metabolic process (GO:0033865)2.79455665
190purine nucleoside bisphosphate metabolic process (GO:0034032)2.79455665
191ribonucleoside bisphosphate metabolic process (GO:0033875)2.79455665
192regulation of guanylate cyclase activity (GO:0031282)2.78894889
193sex determination (GO:0007530)2.76037137
194positive regulation of oligodendrocyte differentiation (GO:0048714)2.74400974
195phosphatidic acid biosynthetic process (GO:0006654)2.72620577
196phosphatidic acid metabolic process (GO:0046473)2.72620577
197protein K11-linked deubiquitination (GO:0035871)13.8880261

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human9.51502044
2SMAD_19615063_ChIP-ChIP_OVARY_Human3.74384260
3GBX2_23144817_ChIP-Seq_PC3_Human3.71075783
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.28444282
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13595319
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00127533
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93647668
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.90150587
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.80550164
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.79971285
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.79654332
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77194363
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77194363
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.64252335
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58876203
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46794545
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.45087840
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36008551
19REST_21632747_ChIP-Seq_MESCs_Mouse2.35206209
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31415703
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30975492
22TP53_16413492_ChIP-PET_HCT116_Human2.28944769
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.26529166
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.14554203
25* IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11520494
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.08591689
27ER_23166858_ChIP-Seq_MCF-7_Human2.07032215
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06609983
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.04651833
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.03798033
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01621093
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96489718
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.94345050
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90098640
35TAF15_26573619_Chip-Seq_HEK293_Human1.81324858
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79775809
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.78518569
38DROSHA_22980978_ChIP-Seq_HELA_Human1.74471196
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.69252240
40AR_21572438_ChIP-Seq_LNCaP_Human1.65826391
41VDR_22108803_ChIP-Seq_LS180_Human1.65711434
42IGF1R_20145208_ChIP-Seq_DFB_Human1.65554339
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64576374
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.63590678
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60980211
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.58001613
47ZNF274_21170338_ChIP-Seq_K562_Hela1.57714983
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57695934
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57041685
50FOXA1_21572438_ChIP-Seq_LNCaP_Human1.54405943
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54398176
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54219256
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53443157
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52658205
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52329649
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.52303201
57OCT4_21477851_ChIP-Seq_ESCs_Mouse1.50875271
58LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50688099
59RNF2_27304074_Chip-Seq_NSC_Mouse1.48129937
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47413975
61* SMAD4_21799915_ChIP-Seq_A2780_Human1.43712020
62CDX2_22108803_ChIP-Seq_LS180_Human1.43004702
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.42935432
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42788907
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.42074567
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.40403992
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38329653
68SMAD4_21741376_ChIP-Seq_EPCs_Human1.37896264
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.37070459
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.36123183
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35616468
72AR_25329375_ChIP-Seq_VCAP_Human1.33930186
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32669468
74P300_19829295_ChIP-Seq_ESCs_Human1.31976683
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.31238520
76SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.30198320
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27041120
78RING1B_27294783_Chip-Seq_ESCs_Mouse1.26343002
79CJUN_26792858_Chip-Seq_BT549_Human1.25760673
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24254378
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.23298488
82FUS_26573619_Chip-Seq_HEK293_Human1.22576396
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21253625
84LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.19910847
85RING1B_27294783_Chip-Seq_NPCs_Mouse1.18266302
86* AR_19668381_ChIP-Seq_PC3_Human1.17908193
87GATA3_21878914_ChIP-Seq_MCF-7_Human1.17336010
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16470696
89STAT3_23295773_ChIP-Seq_U87_Human1.16268754
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15860577
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15860577
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15763863
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.13244613
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13158204
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12500697
96JUN_21703547_ChIP-Seq_K562_Human1.10949291
97TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10912879
98EWS_26573619_Chip-Seq_HEK293_Human1.10832922
99TP53_22573176_ChIP-Seq_HFKS_Human1.09355470
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07529970
101AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07489816
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07008269
103* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05209622
104TBL1_22424771_ChIP-Seq_293T_Human1.04632682
105BP1_19119308_ChIP-ChIP_Hs578T_Human1.03872107
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.02861537
107PHF8_20622853_ChIP-Seq_HELA_Human1.02837225
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02626109
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02304127
110SMAD3_21741376_ChIP-Seq_HESCs_Human1.01861008
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01728051
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01389465
113KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00348739
114KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00348739
115KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00348739
116TP53_18474530_ChIP-ChIP_U2OS_Human0.99997740
117SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.98280479
118WDR5_24793694_ChIP-Seq_LNCAP_Human0.97963777
119AHR_22903824_ChIP-Seq_MCF-7_Human0.97053035
120AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96607854
121JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96323036
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.96013857
123* TCF4_22108803_ChIP-Seq_LS180_Human0.95751204
124FOXA1_25329375_ChIP-Seq_VCAP_Human0.95308910
125FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95308910
126ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94951737
127NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93861524
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.93805424
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93771770
130GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.93204535
131IRF8_22096565_ChIP-ChIP_GC-B_Human0.92883705
132* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92509754
133* RUNX2_22187159_ChIP-Seq_PCA_Human0.91877152
134WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91568318
135MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90853623
136TCF4_23295773_ChIP-Seq_U87_Human0.90387411
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90385325
138GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90142352
139ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90107930
140TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89880697
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88868560
142YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88349856
143NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88077021
144TP53_20018659_ChIP-ChIP_R1E_Mouse0.88005648
145SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87915804
146ERG_20517297_ChIP-Seq_VCAP_Human0.87758587
147STAT1_20625510_ChIP-Seq_HELA_Human0.87690943
148PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.87131691
149WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86887107
150CTCF_27219007_Chip-Seq_Bcells_Human0.86637758
151OCT1_27270436_Chip-Seq_PROSTATE_Human0.86446062
152CDX2_20551321_ChIP-Seq_CACO-2_Human0.86159061
153RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85502758
154CEBPB_22108803_ChIP-Seq_LS180_Human0.85434085
155BCAT_22108803_ChIP-Seq_LS180_Human0.85152631
156ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84799004
157P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84268551
158* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83303140
159VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83086854
160PRDM14_20953172_ChIP-Seq_ESCs_Human0.82944057
161NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81780498
162AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80740062

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.19176949
2MP0003880_abnormal_central_pattern5.71483287
3MP0005670_abnormal_white_adipose5.13439255
4MP0002139_abnormal_hepatobiliary_system4.42014121
5MP0002138_abnormal_hepatobiliary_system4.28708914
6MP0005310_abnormal_salivary_gland4.26522950
7MP0005360_urolithiasis4.10901003
8MP0002822_catalepsy3.99675544
9MP0001968_abnormal_touch/_nociception3.77604975
10MP0003635_abnormal_synaptic_transmissio3.71877594
11MP0008875_abnormal_xenobiotic_pharmacok3.71265003
12MP0002735_abnormal_chemical_nociception3.51395489
13MP0004270_analgesia3.49703942
14MP0002736_abnormal_nociception_after3.49466775
15MP0003806_abnormal_nucleotide_metabolis3.43529563
16* MP0009745_abnormal_behavioral_response3.31200146
17MP0001501_abnormal_sleep_pattern3.30704105
18* MP0002063_abnormal_learning/memory/cond3.01933281
19MP0001984_abnormal_olfaction2.92307498
20* MP0002572_abnormal_emotion/affect_behav2.68104857
21* MP0002064_seizures2.61757915
22MP0002272_abnormal_nervous_system2.60578885
23MP0003787_abnormal_imprinting2.55726748
24MP0005085_abnormal_gallbladder_physiolo2.54877589
25MP0004858_abnormal_nervous_system2.54015874
26MP0001440_abnormal_grooming_behavior2.53745973
27MP0002734_abnormal_mechanical_nocicepti2.45483028
28MP0002733_abnormal_thermal_nociception2.38447305
29MP0006276_abnormal_autonomic_nervous2.27375346
30MP0001486_abnormal_startle_reflex2.17386748
31MP0001970_abnormal_pain_threshold2.12323938
32MP0005423_abnormal_somatic_nervous2.11116480
33MP0005365_abnormal_bile_salt2.08117375
34MP0000230_abnormal_systemic_arterial1.91833250
35MP0003329_amyloid_beta_deposits1.88461256
36MP0002067_abnormal_sensory_capabilities1.81200301
37MP0009046_muscle_twitch1.78981893
38MP0003252_abnormal_bile_duct1.78279647
39MP0006292_abnormal_olfactory_placode1.78248965
40MP0003183_abnormal_peptide_metabolism1.77473312
41MP0001873_stomach_inflammation1.72568512
42MP0002184_abnormal_innervation1.71682569
43MP0010329_abnormal_lipoprotein_level1.64960601
44MP0001666_abnormal_nutrient_absorption1.61171819
45MP0001919_abnormal_reproductive_system1.59998515
46MP0001529_abnormal_vocalization1.51564221
47MP0006082_CNS_inflammation1.49628204
48MP0010386_abnormal_urinary_bladder1.49625872
49MP0003122_maternal_imprinting1.46017798
50MP0002557_abnormal_social/conspecific_i1.43209644
51MP0001879_abnormal_lymphatic_vessel1.42806612
52MP0004811_abnormal_neuron_physiology1.38938492
53MP0001905_abnormal_dopamine_level1.38076739
54MP0000778_abnormal_nervous_system1.35494239
55MP0002909_abnormal_adrenal_gland1.33867478
56MP0005389_reproductive_system_phenotype1.32534669
57MP0000955_abnormal_spinal_cord1.31667618
58MP0001764_abnormal_homeostasis1.29628707
59MP0001188_hyperpigmentation1.28872045
60MP0005332_abnormal_amino_acid1.27024250
61MP0003123_paternal_imprinting1.24655886
62MP0002876_abnormal_thyroid_physiology1.23943561
63MP0004147_increased_porphyrin_level1.22280849
64MP0002882_abnormal_neuron_morphology1.20511670
65MP0004019_abnormal_vitamin_homeostasis1.20046153
66MP0009780_abnormal_chondrocyte_physiolo1.17618189
67MP0005645_abnormal_hypothalamus_physiol1.17184286
68MP0005187_abnormal_penis_morphology1.16661514
69MP0000613_abnormal_salivary_gland1.16274606
70MP0002006_tumorigenesis1.15652344
71MP0002066_abnormal_motor_capabilities/c1.15536400
72MP0003879_abnormal_hair_cell1.14827039
73MP0009643_abnormal_urine_homeostasis1.14675652
74MP0003121_genomic_imprinting1.11802014
75MP0010155_abnormal_intestine_physiology1.11655361
76MP0004142_abnormal_muscle_tone1.11082063
77MP0004085_abnormal_heartbeat1.10787010
78MP0003638_abnormal_response/metabolism_1.07176000
79MP0005377_hearing/vestibular/ear_phenot1.06195253
80MP0003878_abnormal_ear_physiology1.06195253
81MP0004145_abnormal_muscle_electrophysio1.05430556
82MP0005167_abnormal_blood-brain_barrier1.04421185
83MP0003718_maternal_effect1.02814174
84MP0003195_calcinosis1.01108122
85MP0004215_abnormal_myocardial_fiber1.00877495
86MP0002127_abnormal_cardiovascular_syste0.99932985
87MP0003724_increased_susceptibility_to0.99347179
88MP0000569_abnormal_digit_pigmentation0.98381028
89MP0004924_abnormal_behavior0.98238151
90MP0005386_behavior/neurological_phenoty0.98238151
91MP0002971_abnormal_brown_adipose0.95290175
92MP0002118_abnormal_lipid_homeostasis0.94990927
93MP0005646_abnormal_pituitary_gland0.92618632
94MP0008872_abnormal_physiological_respon0.91880193
95MP0008961_abnormal_basal_metabolism0.91843167
96MP0003938_abnormal_ear_development0.90410503
97MP0003137_abnormal_impulse_conducting0.88778716
98MP0008874_decreased_physiological_sensi0.88490659
99MP0000604_amyloidosis0.86237299
100MP0002928_abnormal_bile_duct0.85831244
101MP0004885_abnormal_endolymph0.85540770
102MP0008569_lethality_at_weaning0.84728826
103MP0002837_dystrophic_cardiac_calcinosis0.83864613
104MP0005083_abnormal_biliary_tract0.82736855
105MP0003633_abnormal_nervous_system0.80431435
106MP0001346_abnormal_lacrimal_gland0.80394786
107MP0001664_abnormal_digestion0.80126380
108MP0005394_taste/olfaction_phenotype0.79577201
109MP0005499_abnormal_olfactory_system0.79577201
110MP0002152_abnormal_brain_morphology0.78742297
111MP0001963_abnormal_hearing_physiology0.77552941
112MP0001177_atelectasis0.77037591
113* MP0002069_abnormal_eating/drinking_beha0.75884190
114MP0003646_muscle_fatigue0.75164824
115MP0005084_abnormal_gallbladder_morpholo0.74230101
116MP0006035_abnormal_mitochondrial_morpho0.74059211
117MP0000383_abnormal_hair_follicle0.74022870
118MP0002751_abnormal_autonomic_nervous0.73689628
119MP0001663_abnormal_digestive_system0.73678620
120MP0002229_neurodegeneration0.73584411
121MP0001502_abnormal_circadian_rhythm0.73307388
122MP0002752_abnormal_somatic_nervous0.73020600
123MP0002269_muscular_atrophy0.70263485
124MP0003631_nervous_system_phenotype0.69810873
125MP0002254_reproductive_system_inflammat0.68347527
126MP0002638_abnormal_pupillary_reflex0.68271504
127MP0004043_abnormal_pH_regulation0.68007982
128MP0004484_altered_response_of0.67238124
129MP0003315_abnormal_perineum_morphology0.66483701
130MP0005409_darkened_coat_color0.66429001
131MP0003632_abnormal_nervous_system0.66254344
132MP0005410_abnormal_fertilization0.66106087
133MP0005647_abnormal_sex_gland0.66092636
134MP0010678_abnormal_skin_adnexa0.64360173
135MP0005551_abnormal_eye_electrophysiolog0.63618066
136MP0001756_abnormal_urination0.63079517
137MP0001765_abnormal_ion_homeostasis0.62492345
138MP0004264_abnormal_extraembryonic_tissu0.62110306
139MP0005174_abnormal_tail_pigmentation0.60325962
140MP0005666_abnormal_adipose_tissue0.58321757
141MP0002136_abnormal_kidney_physiology0.56453964
142MP0001348_abnormal_lacrimal_gland0.56221493
143MP0000749_muscle_degeneration0.56079878
144MP0000678_abnormal_parathyroid_gland0.55764151
145MP0003861_abnormal_nervous_system0.55563368
146MP0002090_abnormal_vision0.54818268
147MP0001986_abnormal_taste_sensitivity0.54245954
148MP0000026_abnormal_inner_ear0.54215123
149MP0000427_abnormal_hair_cycle0.52944711
150MP0000249_abnormal_blood_vessel0.52792039
151MP0003011_delayed_dark_adaptation0.52641105
152MP0005595_abnormal_vascular_smooth0.52050587
153MP0003936_abnormal_reproductive_system0.51731774
154MP0003953_abnormal_hormone_level0.51116423
155MP0004084_abnormal_cardiac_muscle0.50446949
156MP0000538_abnormal_urinary_bladder0.50250825
157MP0000751_myopathy0.50249477
158MP0002653_abnormal_ependyma_morphology0.50235826
159MP0003075_altered_response_to0.49736536
160MP0005448_abnormal_energy_balance0.49371980
161MP0005075_abnormal_melanosome_morpholog0.49304358
162MP0010234_abnormal_vibrissa_follicle0.48568101
163MP0005376_homeostasis/metabolism_phenot0.48343817
164MP0001485_abnormal_pinna_reflex0.48146128

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.03605429
2Myokymia (HP:0002411)7.71101958
3Congenital sensorineural hearing impairment (HP:0008527)7.46693364
4Febrile seizures (HP:0002373)6.41645593
5Focal seizures (HP:0007359)5.62215979
6Lower limb hyperreflexia (HP:0002395)5.38616932
7Bilateral sensorineural hearing impairment (HP:0008619)5.24100452
8Abnormality of the lower motor neuron (HP:0002366)5.17499415
9Optic neuritis (HP:0100653)4.91921495
10Retrobulbar optic neuritis (HP:0100654)4.91921495
11Atonic seizures (HP:0010819)4.82686989
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.80748176
13Orchitis (HP:0100796)4.49412550
14Epileptic encephalopathy (HP:0200134)4.45886795
15Hyperventilation (HP:0002883)4.32515832
16Keratoconjunctivitis (HP:0001096)4.29989525
17Dialeptic seizures (HP:0011146)4.24293945
18Generalized tonic-clonic seizures (HP:0002069)4.23895674
19Abnormal pancreas size (HP:0012094)4.10309583
20Poikiloderma (HP:0001029)4.08342706
21Hydroxyprolinuria (HP:0003080)3.97744303
22Abnormality of proline metabolism (HP:0010907)3.97744303
23Hyperglycinuria (HP:0003108)3.89881399
24Visual hallucinations (HP:0002367)3.87163228
25Absence seizures (HP:0002121)3.76740024
26Attenuation of retinal blood vessels (HP:0007843)3.69044058
27Ileus (HP:0002595)3.65649821
28Myositis (HP:0100614)3.61328290
29Abnormality of the pericardium (HP:0001697)3.54534967
30Progressive cerebellar ataxia (HP:0002073)3.48500962
31Amblyopia (HP:0000646)3.48127147
32Drooling (HP:0002307)3.45548167
33Excessive salivation (HP:0003781)3.45548167
34Hypoplasia of the uterus (HP:0000013)3.45520639
35Xanthomatosis (HP:0000991)3.44564061
36Abolished electroretinogram (ERG) (HP:0000550)3.38776186
37Gout (HP:0001997)3.38163988
38Congenital stationary night blindness (HP:0007642)3.29302512
39Bony spicule pigmentary retinopathy (HP:0007737)3.28758202
40Enlarged penis (HP:0000040)3.21489963
41Spastic tetraparesis (HP:0001285)3.18925184
42Keratoconjunctivitis sicca (HP:0001097)3.15504754
43Hemiparesis (HP:0001269)3.15082831
44Bilateral microphthalmos (HP:0007633)3.06761788
45True hermaphroditism (HP:0010459)3.00755509
46Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.99206484
47Dysdiadochokinesis (HP:0002075)2.96165459
48Horizontal nystagmus (HP:0000666)2.94340076
49Abnormality of renin-angiotensin system (HP:0000847)2.93472257
50Abnormality of glycine metabolism (HP:0010895)2.90133332
51Abnormality of serine family amino acid metabolism (HP:0010894)2.90133332
52Late onset (HP:0003584)2.88807506
53Neoplasm of the heart (HP:0100544)2.86569909
54Tinnitus (HP:0000360)2.83511694
55Action tremor (HP:0002345)2.82705301
56Hypochromic microcytic anemia (HP:0004840)2.82505413
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.81580526
58Dysmetria (HP:0001310)2.77046544
59Abnormal social behavior (HP:0012433)2.73208961
60Impaired social interactions (HP:0000735)2.73208961
61Hepatoblastoma (HP:0002884)2.67701187
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.67264238
63Amyotrophic lateral sclerosis (HP:0007354)2.62296088
64Hyperactive renin-angiotensin system (HP:0000841)2.60131871
65Clumsiness (HP:0002312)2.59763143
66Testicular atrophy (HP:0000029)2.59380706
67Pigmentary retinal degeneration (HP:0001146)2.54273888
68Status epilepticus (HP:0002133)2.50974737
69Unilateral renal agenesis (HP:0000122)2.47748328
70Abnormality of chloride homeostasis (HP:0011422)2.45448378
71Broad-based gait (HP:0002136)2.43968757
72Gaze-evoked nystagmus (HP:0000640)2.43942117
73Gonadotropin excess (HP:0000837)2.42472734
74Male pseudohermaphroditism (HP:0000037)2.40717457
75Pancreatic cysts (HP:0001737)2.37650600
76Abnormal glucose tolerance (HP:0001952)2.37193133
77Preaxial foot polydactyly (HP:0001841)2.36467730
78Poor eye contact (HP:0000817)2.36132430
79Bicornuate uterus (HP:0000813)2.36012252
80Preauricular pit (HP:0004467)2.35751521
81Periauricular skin pits (HP:0100277)2.35751521
82Aplasia/hypoplasia of the uterus (HP:0008684)2.35163848
83Decreased circulating renin level (HP:0003351)2.32887479
84Hyperkalemia (HP:0002153)2.32312084
85Abnormal EKG (HP:0003115)2.30715583
86Alkalosis (HP:0001948)2.27991787
87Mesangial abnormality (HP:0001966)2.26809972
88Abnormality of dentin (HP:0010299)2.25244772
89Hemoptysis (HP:0002105)2.24045093
90Abnormality of salivation (HP:0100755)2.21693313
91Pancreatitis (HP:0001733)2.20419586
92Cerebral inclusion bodies (HP:0100314)2.20020039
93CNS demyelination (HP:0007305)2.19500344
94Postural instability (HP:0002172)2.18793127
95Abnormality of dental color (HP:0011073)2.18407853
96Hypokalemia (HP:0002900)2.16590349
97Atrioventricular block (HP:0001678)2.15721996
98Abnormality of the corticospinal tract (HP:0002492)2.13483157
99Epileptiform EEG discharges (HP:0011182)2.10309335
100Spastic paraplegia (HP:0001258)2.09060507
101Increased purine levels (HP:0004368)2.08548323
102Hyperuricemia (HP:0002149)2.08548323
103Pancreatic fibrosis (HP:0100732)2.08479280
104Dysautonomia (HP:0002459)2.08133692
105Acne (HP:0001061)2.07909672
106Abnormality of the vitamin B12 metabolism (HP:0004341)2.07222984
107Akinesia (HP:0002304)2.06370014
108Depression (HP:0000716)2.06205570
109Anxiety (HP:0000739)2.05333523
110Anorexia (HP:0002039)2.04272219
111Resting tremor (HP:0002322)2.02012349
112Chronic hepatic failure (HP:0100626)2.01790077
113Retinal atrophy (HP:0001105)2.01396385
114Glycosuria (HP:0003076)2.01015717
115Abnormality of urine glucose concentration (HP:0011016)2.01015717
116Bradykinesia (HP:0002067)2.00362081
117Heart block (HP:0012722)2.00095405
118Amelogenesis imperfecta (HP:0000705)1.99872995
119Bradycardia (HP:0001662)1.98941303
120Vertigo (HP:0002321)1.98698324
121Absent speech (HP:0001344)1.98688829
122Subaortic stenosis (HP:0001682)1.98653279
123Abnormality of the left ventricular outflow tract (HP:0011103)1.98653279
124Ragged-red muscle fibers (HP:0003200)1.98640801
125Abnormal drinking behavior (HP:0030082)1.98401176
126Polydipsia (HP:0001959)1.98401176
127Abnormality of potassium homeostasis (HP:0011042)1.98316488
128Basal ganglia calcification (HP:0002135)1.98253720
129Bundle branch block (HP:0011710)1.97334001
130Breast carcinoma (HP:0003002)1.96785288
131Encephalitis (HP:0002383)1.96666865
132Torticollis (HP:0000473)1.95937943
133Truncal ataxia (HP:0002078)1.95515905
134Delayed puberty (HP:0000823)1.95263029
135Protruding tongue (HP:0010808)1.94696797
136Hyperglycinemia (HP:0002154)1.94272033
137Microvesicular hepatic steatosis (HP:0001414)1.94078039
138Increased circulating renin level (HP:0000848)1.91696396
139Pulmonary embolism (HP:0002204)1.91617105
140Peripheral demyelination (HP:0011096)1.90963108
141Opisthotonus (HP:0002179)1.90794324
142Supranuclear gaze palsy (HP:0000605)1.90041774
143Abnormality of sulfur amino acid metabolism (HP:0004339)1.88624319
144Adrenal overactivity (HP:0002717)1.88619557
145Nephroblastoma (Wilms tumor) (HP:0002667)1.88521619
146Neurofibrillary tangles (HP:0002185)1.87860838
147Abnormality of vitamin B metabolism (HP:0004340)1.87604629
148Hyperammonemia (HP:0001987)1.87358902
149Prolonged QT interval (HP:0001657)1.86905318
150Craniofacial hyperostosis (HP:0004493)1.86694900
151Onion bulb formation (HP:0003383)1.86352290
152Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86232751
153Focal segmental glomerulosclerosis (HP:0000097)1.85157872
154Impaired vibration sensation in the lower limbs (HP:0002166)1.83635538
155Sensory axonal neuropathy (HP:0003390)1.83424893
156Spastic gait (HP:0002064)1.82781843
157Tented upper lip vermilion (HP:0010804)1.82200423
158Rapidly progressive (HP:0003678)1.82060382
159Fetal akinesia sequence (HP:0001989)1.80562621
160Syncope (HP:0001279)1.79789361
161Deep palmar crease (HP:0006191)1.78950817
162Deeply set eye (HP:0000490)1.78561599
163Anal stenosis (HP:0002025)1.76571304
164Bifid tongue (HP:0010297)1.76162103
165Focal dystonia (HP:0004373)1.74731228
166EEG with generalized epileptiform discharges (HP:0011198)1.74594159
167Hyperaldosteronism (HP:0000859)1.74469007
168Stereotypic behavior (HP:0000733)1.72890736
169Abnormal eating behavior (HP:0100738)1.71054862
170Incomplete penetrance (HP:0003829)1.70706884
171Embryonal renal neoplasm (HP:0011794)1.70124940
172Achilles tendon contracture (HP:0001771)1.69667060
173Ventricular fibrillation (HP:0001663)1.68072608
174Abnormality of binocular vision (HP:0011514)1.67810349
175Diplopia (HP:0000651)1.67810349
176Abnormality of pain sensation (HP:0010832)1.66459940
177Impaired pain sensation (HP:0007328)1.66459940
178Craniofacial dystonia (HP:0012179)1.66214585
179Ependymoma (HP:0002888)1.63775478
180Delusions (HP:0000746)1.62883717
181Inability to walk (HP:0002540)1.62460963
182Hemiplegia (HP:0002301)1.62224922
183Hyperinsulinemic hypoglycemia (HP:0000825)1.61290605
184Anomalous pulmonary venous return (HP:0010772)1.60716565
185Supernumerary nipples (HP:0002558)1.60185449
186Ventricular arrhythmia (HP:0004308)1.60060091
187Generalized hypotonia (HP:0001290)1.59967964
188Generalized myoclonic seizures (HP:0002123)1.59341056
189Open mouth (HP:0000194)1.57509316
190Abnormality of ocular smooth pursuit (HP:0000617)1.56346167
191Skin pits (HP:0100276)1.54235719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.63308724
2WNK36.45773889
3EPHA46.18132190
4NTRK35.16498083
5TXK4.49381805
6PINK13.27970121
7GRK53.16124670
8SIK32.82830978
9ACVR1B2.74735225
10BLK2.58189279
11EEF2K2.49737297
12CDK122.48043654
13MAP3K92.43197872
14RIPK42.39215654
15MAPKAPK32.27706438
16MAP3K42.14256915
17SIK22.13025964
18MAP2K72.12157680
19YES12.07790677
20NTRK12.01753752
21MINK11.98603563
22CASK1.91668611
23CCNB11.89803510
24GRK71.89466070
25MAP2K41.88362982
26NTRK21.83897734
27GRK61.74819507
28CAMK2B1.66444603
29NEK21.61314424
30TNIK1.57410916
31MAP4K21.56941771
32FES1.50017511
33KSR11.49107506
34KSR21.46262163
35PRKCG1.45789874
36MAPKAPK51.43247913
37NME11.41764155
38LMTK21.39022467
39MARK11.36653189
40PLK21.34000690
41CAMK2A1.32277045
42ADRBK21.30223810
43IRAK11.30001122
44CDK51.28512522
45PRKCZ1.26089695
46ZAK1.24115949
47PIK3CA1.20764485
48PAK61.17162981
49TRPM71.09084445
50MATK1.08155261
51MAPK131.05961525
52MARK21.03993376
53BCR1.03772556
54PRPF4B1.01034700
55CAMK1D0.99387449
56TYRO30.98241551
57MAP3K130.98116693
58WNK40.97555328
59GRK10.96153901
60CSK0.93381754
61MAP3K120.92584083
62PTK2B0.92492129
63STK38L0.91346007
64CAMK10.90502470
65CAMK2D0.90147604
66LIMK10.89942835
67STK380.87680143
68MOS0.86730924
69TAOK30.83029080
70DAPK10.82746805
71WNK10.80621549
72BMPR20.79257453
73UHMK10.78519334
74STK240.78080579
75ERN10.78077063
76AKT30.76081931
77EIF2AK30.75614005
78FGR0.75109291
79CAMK2G0.71525882
80FER0.71014098
81MAP3K70.70686034
82CAMK40.69566140
83BMPR1B0.68381316
84PAK30.66203531
85CDK180.65921034
86PRKAA20.65842691
87DAPK20.65634492
88PRKCH0.64710730
89DYRK1A0.60174178
90MET0.59380176
91TTK0.59187085
92MUSK0.59108591
93CDK140.57229573
94PRKCE0.56675518
95ADRBK10.55916762
96CDK150.55720319
97MAPK70.55453740
98MAPK110.55421029
99MST1R0.54925260
100SGK10.54495570
101PDK10.54290264
102CSNK1E0.54067914
103STK390.54038608
104CAMKK10.53712079
105IGF1R0.53226894
106PRKD20.52944876
107MYLK0.52663436
108ARAF0.51817540
109PNCK0.51592711
110TIE10.51543402
111EIF2AK20.49959889
112CDK30.49945205
113PHKG10.49648359
114PHKG20.49648359
115CAMKK20.47929151
116CSF1R0.47796007
117RPS6KA30.47705652
118INSRR0.47264781
119PRKACA0.47007086
120FYN0.46569509
121ERBB20.45896060
122MAP2K10.45816625
123PRKACB0.45716192
124CDK11A0.45091624
125ALK0.43989537
126SGK2230.43282030
127SGK4940.43282030
128PRKCA0.42757948
129PRKD30.42637175
130MAP2K60.42446886
131PRKCB0.41794762
132NUAK10.41593385
133IRAK20.39852391
134PRKACG0.39808852
135MAPK100.36454506
136CSNK1A10.36072006
137PRKG20.35934452
138CHEK20.35376931
139OXSR10.34721403
140MAP3K60.34520491
141BCKDK0.34259066
142CAMK1G0.34191873
143PRKG10.33744231
144OBSCN0.33361634
145DDR20.32729624
146SGK20.32455240
147PKN10.32338219
148FLT30.31437583
149NEK60.31279454
150JAK10.29194570
151PDPK10.28667522
152PLK40.28460317
153RPS6KB20.27117412
154NEK10.25730871
155CHUK0.19831905
156TEC0.18348174
157MST40.15252549
158GSK3A0.14341166
159PRKCQ0.14309453
160CDC42BPA0.12473979
161INSR0.12048166
162TGFBR10.11885932

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.15927234
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.45694431
3Cyanoamino acid metabolism_Homo sapiens_hsa004604.26569278
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.32880642
5Histidine metabolism_Homo sapiens_hsa003403.07853766
6Fat digestion and absorption_Homo sapiens_hsa049753.07356170
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.99548155
8Long-term potentiation_Homo sapiens_hsa047202.90969549
9Glutamatergic synapse_Homo sapiens_hsa047242.89324706
10Circadian entrainment_Homo sapiens_hsa047132.78495039
11GABAergic synapse_Homo sapiens_hsa047272.72221904
12Vitamin digestion and absorption_Homo sapiens_hsa049772.64865681
13Synaptic vesicle cycle_Homo sapiens_hsa047212.46068850
14Arachidonic acid metabolism_Homo sapiens_hsa005902.46054291
15Taste transduction_Homo sapiens_hsa047422.45432579
16Morphine addiction_Homo sapiens_hsa050322.41674361
17Amphetamine addiction_Homo sapiens_hsa050312.39998871
18Dopaminergic synapse_Homo sapiens_hsa047282.28423953
19Selenocompound metabolism_Homo sapiens_hsa004502.26709554
20Steroid hormone biosynthesis_Homo sapiens_hsa001402.23231122
21Salivary secretion_Homo sapiens_hsa049702.15734126
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13092069
23Long-term depression_Homo sapiens_hsa047302.02787651
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00241030
25Butanoate metabolism_Homo sapiens_hsa006501.98103052
26Olfactory transduction_Homo sapiens_hsa047401.92670147
27Propanoate metabolism_Homo sapiens_hsa006401.91024335
28* Serotonergic synapse_Homo sapiens_hsa047261.90406769
29Cholinergic synapse_Homo sapiens_hsa047251.82056930
30Tryptophan metabolism_Homo sapiens_hsa003801.81879047
31* Calcium signaling pathway_Homo sapiens_hsa040201.78564403
32Insulin secretion_Homo sapiens_hsa049111.75295516
33* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74177292
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.72121272
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60855306
36Caffeine metabolism_Homo sapiens_hsa002321.57173590
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55712283
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54426437
39Collecting duct acid secretion_Homo sapiens_hsa049661.51237764
40Oxytocin signaling pathway_Homo sapiens_hsa049211.50615131
41Protein digestion and absorption_Homo sapiens_hsa049741.50136697
42Gastric acid secretion_Homo sapiens_hsa049711.46680482
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.45837163
44Cocaine addiction_Homo sapiens_hsa050301.44870384
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.43122591
46Renin secretion_Homo sapiens_hsa049241.42386025
47Starch and sucrose metabolism_Homo sapiens_hsa005001.36524850
48Axon guidance_Homo sapiens_hsa043601.34549193
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34340081
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33879161
51GnRH signaling pathway_Homo sapiens_hsa049121.33691273
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33367532
53Fatty acid degradation_Homo sapiens_hsa000711.32665721
54* cAMP signaling pathway_Homo sapiens_hsa040241.29767857
55Chemical carcinogenesis_Homo sapiens_hsa052041.27864268
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25588841
57Arginine biosynthesis_Homo sapiens_hsa002201.24725516
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23820000
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19788246
60ABC transporters_Homo sapiens_hsa020101.18064280
61Maturity onset diabetes of the young_Homo sapiens_hsa049501.17987070
62Cardiac muscle contraction_Homo sapiens_hsa042601.17550402
63Retinol metabolism_Homo sapiens_hsa008301.15765164
64Staphylococcus aureus infection_Homo sapiens_hsa051501.15363218
65Choline metabolism in cancer_Homo sapiens_hsa052311.15076877
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15064462
67Glutathione metabolism_Homo sapiens_hsa004801.13945122
68PPAR signaling pathway_Homo sapiens_hsa033201.10568964
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09728857
70Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09091714
71N-Glycan biosynthesis_Homo sapiens_hsa005101.08839892
72Vitamin B6 metabolism_Homo sapiens_hsa007501.03589869
73Gap junction_Homo sapiens_hsa045401.02944492
74Phospholipase D signaling pathway_Homo sapiens_hsa040721.01788086
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00851839
76Type II diabetes mellitus_Homo sapiens_hsa049301.00171769
77Vibrio cholerae infection_Homo sapiens_hsa051100.98304764
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97594976
79Estrogen signaling pathway_Homo sapiens_hsa049150.96765309
80Pancreatic secretion_Homo sapiens_hsa049720.93965728
81Peroxisome_Homo sapiens_hsa041460.92043694
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90427090
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90004985
84Nitrogen metabolism_Homo sapiens_hsa009100.85080890
85Fatty acid biosynthesis_Homo sapiens_hsa000610.84719704
86Fatty acid metabolism_Homo sapiens_hsa012120.84404620
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.83616741
88ErbB signaling pathway_Homo sapiens_hsa040120.82570214
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81896248
90Arginine and proline metabolism_Homo sapiens_hsa003300.81330096
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.80475540
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76407472
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76390120
94Melanogenesis_Homo sapiens_hsa049160.74385083
95Glioma_Homo sapiens_hsa052140.71326763
96Thyroid hormone synthesis_Homo sapiens_hsa049180.67287941
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62808497
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62486528
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62424305
100Dilated cardiomyopathy_Homo sapiens_hsa054140.61670121
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.60886827
102Rap1 signaling pathway_Homo sapiens_hsa040150.60057535
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56849367
104Mineral absorption_Homo sapiens_hsa049780.56767574
105Galactose metabolism_Homo sapiens_hsa000520.56555329
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56240172
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.55809373
108Bile secretion_Homo sapiens_hsa049760.55633933
109Lysine degradation_Homo sapiens_hsa003100.55173894
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54553554
111African trypanosomiasis_Homo sapiens_hsa051430.53832965
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53641244
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.53615317
114Alzheimers disease_Homo sapiens_hsa050100.52642419
115Ras signaling pathway_Homo sapiens_hsa040140.51282914
116VEGF signaling pathway_Homo sapiens_hsa043700.50110892
117MAPK signaling pathway_Homo sapiens_hsa040100.48502436
118mTOR signaling pathway_Homo sapiens_hsa041500.48153106
119Metabolic pathways_Homo sapiens_hsa011000.46768330
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45399315
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44562830
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.44423534
123Inositol phosphate metabolism_Homo sapiens_hsa005620.42880516
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42825939
125Pyruvate metabolism_Homo sapiens_hsa006200.41904233
126Oocyte meiosis_Homo sapiens_hsa041140.41722196
127Sphingolipid metabolism_Homo sapiens_hsa006000.38880688
128Glucagon signaling pathway_Homo sapiens_hsa049220.38364059
129Ether lipid metabolism_Homo sapiens_hsa005650.36838787
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36704249
131Glycerolipid metabolism_Homo sapiens_hsa005610.35984924
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35085299
133Ovarian steroidogenesis_Homo sapiens_hsa049130.34040549
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.33544306
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33078033
136Dorso-ventral axis formation_Homo sapiens_hsa043200.33068714
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32921764
138Oxidative phosphorylation_Homo sapiens_hsa001900.32410234
139Wnt signaling pathway_Homo sapiens_hsa043100.31897965
140Phototransduction_Homo sapiens_hsa047440.30485693
141Sulfur metabolism_Homo sapiens_hsa009200.27546624
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27154136
143Renin-angiotensin system_Homo sapiens_hsa046140.26273819
144Type I diabetes mellitus_Homo sapiens_hsa049400.26029380
145Fructose and mannose metabolism_Homo sapiens_hsa000510.24693007
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24037386
147Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22545837
148Circadian rhythm_Homo sapiens_hsa047100.19489605
149Alcoholism_Homo sapiens_hsa050340.17615346
150Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16054418
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15662009
152Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15074860
153Linoleic acid metabolism_Homo sapiens_hsa005910.14290967
154Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13359189
155Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13076514
156Tyrosine metabolism_Homo sapiens_hsa003500.12969356

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