HTR5BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1snRNA transcription (GO:0009301)8.50294541
2negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)7.00578486
3negative regulation of receptor activity (GO:2000272)6.45817649
4positive regulation of lipoprotein lipase activity (GO:0051006)6.25587483
5positive regulation of triglyceride lipase activity (GO:0061365)6.25587483
6deoxyribonucleotide catabolic process (GO:0009264)5.24029806
7phosphorelay signal transduction system (GO:0000160)5.16336155
8keratinocyte development (GO:0003334)4.98097340
9deoxyribose phosphate catabolic process (GO:0046386)4.71337517
10L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.56068180
11multicellular organism reproduction (GO:0032504)4.51677295
12sulfur amino acid catabolic process (GO:0000098)4.47130590
13negative regulation of cAMP-mediated signaling (GO:0043951)4.45935398
14oocyte development (GO:0048599)4.28702170
15regulation of female gonad development (GO:2000194)4.26567277
16deoxyribose phosphate metabolic process (GO:0019692)4.22193554
17negative regulation of protein tyrosine kinase activity (GO:0061099)4.21447354
18DNA deamination (GO:0045006)4.11675584
19positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.04850472
20histone-serine phosphorylation (GO:0035404)4.03135997
21deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.03026728
22respiratory chain complex IV assembly (GO:0008535)4.02070495
23DNA damage response, detection of DNA damage (GO:0042769)3.87306451
24deoxyribonucleotide metabolic process (GO:0009262)3.81220560
25negative regulation of cytosolic calcium ion concentration (GO:0051481)3.73788423
26peptidyl-histidine modification (GO:0018202)3.73642096
27rRNA catabolic process (GO:0016075)3.69877275
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.66949678
29L-methionine salvage (GO:0071267)3.65144271
30L-methionine biosynthetic process (GO:0071265)3.65144271
31amino acid salvage (GO:0043102)3.65144271
32positive regulation of sodium ion transmembrane transport (GO:1902307)3.63230502
33single strand break repair (GO:0000012)3.62871106
34plasma lipoprotein particle clearance (GO:0034381)3.62051920
35regulation of DNA methylation (GO:0044030)3.58337445
36intestinal cholesterol absorption (GO:0030299)3.55415917
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.52448066
38nodal signaling pathway (GO:0038092)3.51758477
39somite rostral/caudal axis specification (GO:0032525)3.48979686
40female gamete generation (GO:0007292)3.46363735
41purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.44782534
42negative regulation of hormone biosynthetic process (GO:0032353)3.37532811
43maturation of 5.8S rRNA (GO:0000460)3.36815079
44regulation of cilium movement (GO:0003352)3.34401922
45nonmotile primary cilium assembly (GO:0035058)3.34189206
46folic acid-containing compound biosynthetic process (GO:0009396)3.28564210
47cAMP catabolic process (GO:0006198)3.25425357
48atrial cardiac muscle cell action potential (GO:0086014)3.23758942
49negative regulation of response to food (GO:0032096)3.21399301
50negative regulation of appetite (GO:0032099)3.21399301
51SMAD protein complex assembly (GO:0007183)3.19547817
52base-excision repair, AP site formation (GO:0006285)3.18543519
53establishment of melanosome localization (GO:0032401)3.12817898
54regulation of acrosome reaction (GO:0060046)3.11422615
55melanosome transport (GO:0032402)3.08495896
56regulation of triglyceride metabolic process (GO:0090207)3.07363911
57rRNA modification (GO:0000154)3.06362634
58cytidine deamination (GO:0009972)3.04365791
59cytidine metabolic process (GO:0046087)3.04365791
60cytidine catabolic process (GO:0006216)3.04365791
61DNA integration (GO:0015074)3.02883926
62pyrimidine nucleotide catabolic process (GO:0006244)2.99410190
63aerobic respiration (GO:0009060)2.99106648
64deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.98253488
65nucleoside transmembrane transport (GO:1901642)2.97907161
66transcription from RNA polymerase III promoter (GO:0006383)2.95998694
67histone H2A acetylation (GO:0043968)2.93673768
68regulation of energy homeostasis (GO:2000505)2.93166193
69establishment of pigment granule localization (GO:0051905)2.92548899
70histone mRNA catabolic process (GO:0071044)2.91861770
71pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.91653408
72sensory perception of smell (GO:0007608)2.91575542
73rRNA methylation (GO:0031167)2.89899752
74purine-containing compound salvage (GO:0043101)2.89512520
75oxidative phosphorylation (GO:0006119)2.88950976
762-deoxyribonucleotide metabolic process (GO:0009394)2.88410659
77brain morphogenesis (GO:0048854)2.88328759
78pigment granule transport (GO:0051904)2.87502033
79left/right axis specification (GO:0070986)2.87214744
80negative regulation of T cell differentiation in thymus (GO:0033085)2.86167246
81purine deoxyribonucleotide metabolic process (GO:0009151)2.85775926
82regulation of mitotic spindle organization (GO:0060236)2.85663059
83negative regulation of androgen receptor signaling pathway (GO:0060766)2.84598191
84cartilage morphogenesis (GO:0060536)2.82509748
85meiotic cell cycle (GO:0051321)2.81136353
86behavioral response to ethanol (GO:0048149)2.78766693
87cyclic nucleotide catabolic process (GO:0009214)2.78631981
88single fertilization (GO:0007338)2.78401288
89reproduction (GO:0000003)2.77715946
90artery smooth muscle contraction (GO:0014824)2.77511584
91regulation of exit from mitosis (GO:0007096)2.75860263
92histone H3-K36 demethylation (GO:0070544)2.75429519
93positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.74837684
94somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74400960
95somatic hypermutation of immunoglobulin genes (GO:0016446)2.74400960
96negative regulation of hormone metabolic process (GO:0032351)2.73386413
97cytochrome complex assembly (GO:0017004)2.70214293
98regulation of spindle organization (GO:0090224)2.67235749
99negative regulation of protein autophosphorylation (GO:0031953)2.66909656
100microtubule anchoring (GO:0034453)2.63443273

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.76628488
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.92439703
3IGF1R_20145208_ChIP-Seq_DFB_Human4.69651468
4NOTCH1_21737748_ChIP-Seq_TLL_Human3.94425885
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.25898014
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.04934781
7ZNF274_21170338_ChIP-Seq_K562_Hela2.98474192
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.49575278
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.45967737
10GBX2_23144817_ChIP-Seq_PC3_Human2.31711423
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29834782
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28082124
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.27644089
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.26082468
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12408537
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94227084
17ELK1_19687146_ChIP-ChIP_HELA_Human1.91232828
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90440185
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87372966
20TAF15_26573619_Chip-Seq_HEK293_Human1.85360762
21TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84964563
22POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.84964563
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78897189
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.72552957
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72065716
26ER_23166858_ChIP-Seq_MCF-7_Human1.65146912
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62395930
28VDR_23849224_ChIP-Seq_CD4+_Human1.57733785
29EWS_26573619_Chip-Seq_HEK293_Human1.54631167
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48761194
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47372695
32VDR_22108803_ChIP-Seq_LS180_Human1.43271988
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42121560
34MYC_18940864_ChIP-ChIP_HL60_Human1.40983976
35P300_19829295_ChIP-Seq_ESCs_Human1.38527147
36SMAD4_21799915_ChIP-Seq_A2780_Human1.35276652
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27499497
38CBP_20019798_ChIP-Seq_JUKART_Human1.27499497
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.27026318
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26243468
41TCF4_23295773_ChIP-Seq_U87_Human1.26056188
42BCAT_22108803_ChIP-Seq_LS180_Human1.25786803
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24568873
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22361078
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.22292643
46STAT3_23295773_ChIP-Seq_U87_Human1.20627361
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19480872
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17021609
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14072244
50AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14040655
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13197171
52AR_20517297_ChIP-Seq_VCAP_Human1.12901614
53FLI1_21867929_ChIP-Seq_TH2_Mouse1.12683100
54FOXP3_21729870_ChIP-Seq_TREG_Human1.10813086
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.09834154
56TP53_22573176_ChIP-Seq_HFKS_Human1.09352422
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06680829
58GATA3_26560356_Chip-Seq_TH2_Human1.03837203
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02881633
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00881173
61SMRT_27268052_Chip-Seq_Bcells_Human1.00826898
62ERA_21632823_ChIP-Seq_H3396_Human1.00773475
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00656117
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.00275482
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99733354
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99519681
67GATA3_21878914_ChIP-Seq_MCF-7_Human0.98680366
68AR_25329375_ChIP-Seq_VCAP_Human0.98495818
69PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97402678
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96495026
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.95571497
72AHR_22903824_ChIP-Seq_MCF-7_Human0.94499515
73CRX_20693478_ChIP-Seq_RETINA_Mouse0.94425680
74NANOG_19829295_ChIP-Seq_ESCs_Human0.93544525
75SOX2_19829295_ChIP-Seq_ESCs_Human0.93544525
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92773543
77JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.92265760
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91813758
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90735387
80SALL4_22934838_ChIP-ChIP_CD34+_Human0.90633269
81RUNX2_22187159_ChIP-Seq_PCA_Human0.90358329
82SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90184268
83PRDM14_20953172_ChIP-Seq_ESCs_Human0.89374771
84NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89174745
85FUS_26573619_Chip-Seq_HEK293_Human0.87973607
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87959282
87KDM2B_26808549_Chip-Seq_REH_Human0.86972209
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85057881
89FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.84727154
90EZH2_27304074_Chip-Seq_ESCs_Mouse0.83756097
91PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83611840
92ERG_20517297_ChIP-Seq_VCAP_Human0.83451200
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81683129
94TAF2_19829295_ChIP-Seq_ESCs_Human0.81305493
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.81232101
96SOX2_21211035_ChIP-Seq_LN229_Gbm0.79925327
97CDX2_22108803_ChIP-Seq_LS180_Human0.79767025
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79330527
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79072941
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.78116877

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001661_extended_life_span4.93355645
2MP0003890_abnormal_embryonic-extraembry4.21612720
3MP0003718_maternal_effect4.20737539
4MP0008789_abnormal_olfactory_epithelium3.85257597
5MP0005499_abnormal_olfactory_system3.33713251
6MP0005394_taste/olfaction_phenotype3.33713251
7MP0000569_abnormal_digit_pigmentation3.15952910
8MP0000427_abnormal_hair_cycle2.51846140
9MP0002160_abnormal_reproductive_system2.40237703
10MP0003045_fibrosis2.32186813
11MP0008057_abnormal_DNA_replication2.23253369
12MP0005646_abnormal_pituitary_gland2.20678166
13MP0001986_abnormal_taste_sensitivity2.18241915
14MP0002295_abnormal_pulmonary_circulatio2.15297198
15MP0003646_muscle_fatigue2.11646258
16MP0008877_abnormal_DNA_methylation2.08690926
17MP0005395_other_phenotype2.05702503
18MP0005266_abnormal_metabolism2.03670777
19MP0003693_abnormal_embryo_hatching1.98909559
20MP0001968_abnormal_touch/_nociception1.91350696
21MP0004145_abnormal_muscle_electrophysio1.77451211
22MP0010307_abnormal_tumor_latency1.75450935
23MP0001764_abnormal_homeostasis1.68119499
24MP0005551_abnormal_eye_electrophysiolog1.66850538
25MP0001727_abnormal_embryo_implantation1.62326189
26MP0001984_abnormal_olfaction1.60047021
27MP0005389_reproductive_system_phenotype1.55054015
28MP0003195_calcinosis1.54206024
29MP0004133_heterotaxia1.51759147
30MP0003959_abnormal_lean_body1.51162603
31MP0001529_abnormal_vocalization1.48195293
32MP0009278_abnormal_bone_marrow1.47948669
33MP0005253_abnormal_eye_physiology1.46985736
34MP0005647_abnormal_sex_gland1.45060822
35MP0003786_premature_aging1.45019501
36MP0001929_abnormal_gametogenesis1.44972784
37MP0005360_urolithiasis1.43942261
38MP0006292_abnormal_olfactory_placode1.43842660
39MP0010352_gastrointestinal_tract_polyps1.36494650
40MP0003172_abnormal_lysosome_physiology1.35481481
41MP0005084_abnormal_gallbladder_morpholo1.33504484
42MP0006036_abnormal_mitochondrial_physio1.33157908
43MP0004510_myositis1.32162786
44MP0009697_abnormal_copulation1.31012840
45MP0002282_abnormal_trachea_morphology1.30189023
46MP0009384_cardiac_valve_regurgitation1.29325499
47MP0005376_homeostasis/metabolism_phenot1.28604813
48MP0005410_abnormal_fertilization1.27941773
49MP0005584_abnormal_enzyme/coenzyme_acti1.25656565
50MP0005645_abnormal_hypothalamus_physiol1.22888724
51MP0001119_abnormal_female_reproductive1.20328634
52MP0003950_abnormal_plasma_membrane1.19353310
53MP0002277_abnormal_respiratory_mucosa1.13194788
54MP0003699_abnormal_female_reproductive1.10880777
55MP0000653_abnormal_sex_gland1.10652257
56MP0002210_abnormal_sex_determination1.09275673
57MP0009333_abnormal_splenocyte_physiolog1.08735477
58MP0001501_abnormal_sleep_pattern1.08315176
59MP0001944_abnormal_pancreas_morphology1.07976075
60MP0003252_abnormal_bile_duct1.05714454
61MP0001485_abnormal_pinna_reflex1.05411059
62MP0002693_abnormal_pancreas_physiology1.04894173
63MP0005670_abnormal_white_adipose1.04301662
64MP0000470_abnormal_stomach_morphology0.98414587
65MP0000631_abnormal_neuroendocrine_gland0.98293793
66MP0000749_muscle_degeneration0.94039692
67MP0005391_vision/eye_phenotype0.85783672
68MP0008775_abnormal_heart_ventricle0.83679588
69MP0002161_abnormal_fertility/fecundity0.83206404
70MP0002928_abnormal_bile_duct0.79249372
71MP0008058_abnormal_DNA_repair0.78205727
72MP0002233_abnormal_nose_morphology0.77675350
73MP0005636_abnormal_mineral_homeostasis0.76619316
74MP0002168_other_aberrant_phenotype0.76332182
75MP0002733_abnormal_thermal_nociception0.75427598
76MP0002249_abnormal_larynx_morphology0.75382760
77MP0002111_abnormal_tail_morphology0.72225032
78MP0005448_abnormal_energy_balance0.71825375
79MP0001542_abnormal_bone_strength0.71788820
80MP0001664_abnormal_digestion0.71631350
81MP0010329_abnormal_lipoprotein_level0.67025208
82MP0005379_endocrine/exocrine_gland_phen0.66315832
83MP0002163_abnormal_gland_morphology0.66223673
84MP0003698_abnormal_male_reproductive0.66112076
85MP0009764_decreased_sensitivity_to0.64623238
86MP0002735_abnormal_chemical_nociception0.64289869
87MP0005452_abnormal_adipose_tissue0.63991177
88MP0001324_abnormal_eye_pigmentation0.63933281
89MP0005397_hematopoietic_system_phenotyp0.63600330
90MP0001545_abnormal_hematopoietic_system0.63600330
91MP0001730_embryonic_growth_arrest0.63264370
92MP0001145_abnormal_male_reproductive0.62928866
93MP0002132_abnormal_respiratory_system0.59510197
94MP0005195_abnormal_posterior_eye0.59508534
95MP0004043_abnormal_pH_regulation0.58842004
96MP0005671_abnormal_response_to0.57889110
97MP0006276_abnormal_autonomic_nervous0.56658496
98MP0005085_abnormal_gallbladder_physiolo0.56186798
99MP0002118_abnormal_lipid_homeostasis0.55682270
100MP0004197_abnormal_fetal_growth/weight/0.55280566

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)5.18738485
2Hepatic necrosis (HP:0002605)5.05857331
3Molar tooth sign on MRI (HP:0002419)4.49303139
4Abnormality of midbrain morphology (HP:0002418)4.49303139
5Hypothermia (HP:0002045)4.39427079
6Abnormality of abdominal situs (HP:0011620)4.10883811
7Abdominal situs inversus (HP:0003363)4.10883811
8Generalized aminoaciduria (HP:0002909)3.83050890
9Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.78178237
10Conjunctival telangiectasia (HP:0000524)3.67824580
11Colon cancer (HP:0003003)3.54020691
12Abnormality of alanine metabolism (HP:0010916)3.51596150
13Hyperalaninemia (HP:0003348)3.51596150
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.51596150
15Spontaneous hematomas (HP:0007420)3.37393123
16Hypoplastic iliac wings (HP:0002866)3.18818726
17Hydroureter (HP:0000072)3.18673867
18Broad ribs (HP:0000885)3.18569084
19Medial flaring of the eyebrow (HP:0010747)3.18110809
20Adactyly (HP:0009776)3.05963373
21Abnormality of the vasculature of the conjunctiva (HP:0008054)3.04979353
22Congenital primary aphakia (HP:0007707)3.02043326
23Aplasia/Hypoplasia of the uvula (HP:0010293)3.00087593
24Abnormality of the renal cortex (HP:0011035)2.98947265
25Mitochondrial inheritance (HP:0001427)2.96548960
26Poor coordination (HP:0002370)2.91258190
27Renal cortical cysts (HP:0000803)2.88449759
28Gait imbalance (HP:0002141)2.86227006
29Increased CSF lactate (HP:0002490)2.81757802
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.77618089
31High anterior hairline (HP:0009890)2.74716103
32Microretrognathia (HP:0000308)2.72748914
33Pendular nystagmus (HP:0012043)2.72341855
34Hyperglycinuria (HP:0003108)2.65261761
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.62243989
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.62243989
37Portal hypertension (HP:0001409)2.61587806
38Chronic hepatic failure (HP:0100626)2.58313507
39Pancreatic cysts (HP:0001737)2.58143936
40Chronic diarrhea (HP:0002028)2.53613748
41Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51642830
42Abnormal protein N-linked glycosylation (HP:0012347)2.51642830
43Abnormal protein glycosylation (HP:0012346)2.51642830
44Abnormal glycosylation (HP:0012345)2.51642830
45Pancreatic fibrosis (HP:0100732)2.50907132
46Aplasia/Hypoplasia of the nipples (HP:0006709)2.49834191
47Nephrogenic diabetes insipidus (HP:0009806)2.48474119
48Petechiae (HP:0000967)2.42220229
49Abnormality of the hepatic vasculature (HP:0006707)2.40255548
50Aplasia/Hypoplasia of the fovea (HP:0008060)2.39878887
51Hypoplasia of the fovea (HP:0007750)2.39878887
52Nephronophthisis (HP:0000090)2.38770505
53Bony spicule pigmentary retinopathy (HP:0007737)2.38104904
54Acute encephalopathy (HP:0006846)2.37856367
55Respiratory failure (HP:0002878)2.34576070
56Median cleft lip (HP:0000161)2.33859211
57Acute necrotizing encephalopathy (HP:0006965)2.32392686
58Sclerocornea (HP:0000647)2.29983899
59Aplasia/Hypoplasia of the tibia (HP:0005772)2.26068368
60Septate vagina (HP:0001153)2.24010780
61Congenital hepatic fibrosis (HP:0002612)2.23823992
62Disproportionate short-trunk short stature (HP:0003521)2.22539070
63Metaphyseal irregularity (HP:0003025)2.22228493
64Hematochezia (HP:0002573)2.21346127
65Highly arched eyebrow (HP:0002553)2.19835944
663-Methylglutaconic aciduria (HP:0003535)2.19269665
67Abnormality of the renal medulla (HP:0100957)2.18514718
68Supernumerary spleens (HP:0009799)2.17340246
69Short tibia (HP:0005736)2.16888226
70Rectal prolapse (HP:0002035)2.16520057
71Progressive macrocephaly (HP:0004481)2.16099915
72Attenuation of retinal blood vessels (HP:0007843)2.12772852
73True hermaphroditism (HP:0010459)2.12588215
74Truncal obesity (HP:0001956)2.11691685
75Preaxial hand polydactyly (HP:0001177)2.10041939
76CNS demyelination (HP:0007305)2.09357030
77Oligodactyly (hands) (HP:0001180)2.08636497
78Abnormality of the basal ganglia (HP:0002134)2.05508256
79Genital tract atresia (HP:0001827)2.04663659
80Abnormality of the columella (HP:0009929)2.02848636
81Lactic acidosis (HP:0003128)2.00881328
82Abnormality of the fovea (HP:0000493)1.95397386
83Hip dysplasia (HP:0001385)1.92113421
84Hypoglycemic coma (HP:0001325)1.91112748
85Abolished electroretinogram (ERG) (HP:0000550)1.90995829
86Abnormality of DNA repair (HP:0003254)1.90503361
87Hypoalbuminemia (HP:0003073)1.85982032
88Abnormal albumin level (HP:0012116)1.85982032
89Vaginal atresia (HP:0000148)1.85329565
90Flared iliac wings (HP:0002869)1.84592396
91Abnormal mitochondria in muscle tissue (HP:0008316)1.81935955
92Microcytic anemia (HP:0001935)1.81644847
93Vitreoretinal degeneration (HP:0000655)1.81549162
94Postaxial foot polydactyly (HP:0001830)1.80449902
95Chorioretinal atrophy (HP:0000533)1.77858203
96Hypoplasia of the uterus (HP:0000013)1.77825784
97Tarsal synostosis (HP:0008368)1.77296517
98Oculomotor apraxia (HP:0000657)1.76173570
99Autoimmune thrombocytopenia (HP:0001973)1.74020502
100Rectal fistula (HP:0100590)1.70064986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK94.58516256
2ADRBK24.37882988
3NUAK13.88918145
4BMPR1B3.17727392
5NLK2.79690107
6DAPK22.76551337
7INSRR2.72154081
8MAP3K132.61893760
9FRK2.46193586
10MAP3K42.40531767
11STK242.39300461
12BUB12.31537059
13NME12.19919754
14TNK22.17493133
15MAP3K71.94513426
16IRAK11.93792613
17NTRK31.90027632
18STK31.69365402
19CAMKK21.58679662
20STK38L1.57520856
21MST41.52735935
22PTK2B1.46272828
23CHUK1.42623334
24MELK1.42540870
25TEC1.40813451
26CDC71.36291058
27BRSK21.32714077
28TAOK31.28113769
29ACVR1B1.20867721
30MAP3K91.20259501
31ARAF1.17547692
32TRIM281.15847234
33PDK21.08213891
34TXK1.08158834
35GRK11.03458458
36PNCK0.98807618
37PRKAA20.95686010
38EIF2AK30.93198960
39CAMK1D0.90765276
40STK110.90052570
41MAP4K20.86800577
42IKBKB0.86398145
43CAMK1G0.82404316
44CSNK1A1L0.80793603
45PIK3CA0.79933408
46PASK0.76481558
47CDK90.75111857
48IRAK40.74790762
49PAK30.73624909
50CDK80.72266664
51CAMK40.72071836
52PIK3CG0.69855714
53MAPKAPK50.69461634
54TNIK0.68705011
55ITK0.67364116
56DYRK1A0.67100787
57ADRBK10.66937677
58IRAK20.65699198
59DYRK30.65579488
60RAF10.65483978
61BTK0.63180878
62TRPM70.63095197
63CSNK1G30.62602640
64CSNK1G10.62209709
65MAP3K10.60904368
66PRKCG0.60610352
67WEE10.58103814
68TGFBR10.57926742
69MAP4K10.56779278
70MAPKAPK30.55593180
71BRSK10.52672779
72MAP2K20.52630134
73VRK10.51765019
74OXSR10.49199508
75MAP2K70.48669388
76CAMK2A0.47290996
77CDK120.46154724
78LATS10.45253989
79IKBKE0.44384386
80BLK0.44240781
81MAP2K40.42853160
82VRK20.42461453
83CSNK1G20.42373524
84CASK0.41205010
85CDK70.40179495
86NEK60.40137319
87PRKCE0.39549779
88MAPK150.39532901
89CSNK1E0.38753549
90PLK10.36541885
91AKT20.36511527
92PLK40.34883471
93AKT10.32769342
94PRKCQ0.32214431
95PRKAA10.32016001
96PRKD30.31033763
97DAPK10.31006254
98PRKG10.29903270
99CHEK10.28549156
100YES10.28495228

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009207.36673217
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.37996365
3Protein export_Homo sapiens_hsa030603.93127539
4RNA polymerase_Homo sapiens_hsa030202.95057392
5Type II diabetes mellitus_Homo sapiens_hsa049302.45766493
6Folate biosynthesis_Homo sapiens_hsa007902.42015045
7One carbon pool by folate_Homo sapiens_hsa006702.40054959
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.10321830
9Basal transcription factors_Homo sapiens_hsa030222.07198844
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.88356001
11Oxidative phosphorylation_Homo sapiens_hsa001901.83709720
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.72144009
13Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.55440957
14Fanconi anemia pathway_Homo sapiens_hsa034601.55275740
15p53 signaling pathway_Homo sapiens_hsa041151.53657402
16Base excision repair_Homo sapiens_hsa034101.50549418
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.42970099
18Dorso-ventral axis formation_Homo sapiens_hsa043201.40089734
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38609749
20Parkinsons disease_Homo sapiens_hsa050121.36963595
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.35717677
22Homologous recombination_Homo sapiens_hsa034401.33832748
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28228697
24Butanoate metabolism_Homo sapiens_hsa006501.27234713
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27146969
26Huntingtons disease_Homo sapiens_hsa050161.27097531
27Regulation of autophagy_Homo sapiens_hsa041401.23278768
28RNA degradation_Homo sapiens_hsa030181.18638179
29Circadian rhythm_Homo sapiens_hsa047101.17890150
30Prolactin signaling pathway_Homo sapiens_hsa049171.09771565
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.06466830
32Morphine addiction_Homo sapiens_hsa050321.02218537
33Mismatch repair_Homo sapiens_hsa034301.02061927
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01820054
35Ovarian steroidogenesis_Homo sapiens_hsa049131.00256012
36Collecting duct acid secretion_Homo sapiens_hsa049660.97052895
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91006002
38Cell cycle_Homo sapiens_hsa041100.88025002
39Pyrimidine metabolism_Homo sapiens_hsa002400.86113529
40Alzheimers disease_Homo sapiens_hsa050100.85666328
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.84419421
42Taste transduction_Homo sapiens_hsa047420.81516547
43Pentose phosphate pathway_Homo sapiens_hsa000300.81102831
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.80838220
45Chemical carcinogenesis_Homo sapiens_hsa052040.80510058
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79382291
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79163252
48TGF-beta signaling pathway_Homo sapiens_hsa043500.77885524
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76833693
50FoxO signaling pathway_Homo sapiens_hsa040680.75757796
51Purine metabolism_Homo sapiens_hsa002300.75738523
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75527695
53ABC transporters_Homo sapiens_hsa020100.72718947
54Fatty acid elongation_Homo sapiens_hsa000620.71614335
55Nitrogen metabolism_Homo sapiens_hsa009100.71014598
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69237969
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68577968
58Linoleic acid metabolism_Homo sapiens_hsa005910.65213994
59Retinol metabolism_Homo sapiens_hsa008300.60594031
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.58017277
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.57741487
62Olfactory transduction_Homo sapiens_hsa047400.56627637
63Mineral absorption_Homo sapiens_hsa049780.55997401
64Lysine degradation_Homo sapiens_hsa003100.55847076
65RNA transport_Homo sapiens_hsa030130.54496942
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53692901
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53052961
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49557653
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47854289
70Proteasome_Homo sapiens_hsa030500.47040048
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46859404
72Vitamin digestion and absorption_Homo sapiens_hsa049770.46607589
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46497328
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45893716
75N-Glycan biosynthesis_Homo sapiens_hsa005100.42325061
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42192500
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40685034
78Measles_Homo sapiens_hsa051620.40556314
79Glycerolipid metabolism_Homo sapiens_hsa005610.38871236
80Phototransduction_Homo sapiens_hsa047440.37173448
81Insulin secretion_Homo sapiens_hsa049110.36671831
82Rheumatoid arthritis_Homo sapiens_hsa053230.35336817
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34698842
84Fat digestion and absorption_Homo sapiens_hsa049750.34644978
85Chemokine signaling pathway_Homo sapiens_hsa040620.31530249
86Nicotine addiction_Homo sapiens_hsa050330.31316610
87Metabolic pathways_Homo sapiens_hsa011000.31162273
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30891274
89Propanoate metabolism_Homo sapiens_hsa006400.29494557
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28344188
91Oocyte meiosis_Homo sapiens_hsa041140.27680793
92Hepatitis B_Homo sapiens_hsa051610.26112595
93Hematopoietic cell lineage_Homo sapiens_hsa046400.26101864
94Circadian entrainment_Homo sapiens_hsa047130.24568703
95Calcium signaling pathway_Homo sapiens_hsa040200.24104046
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23902813
97Inositol phosphate metabolism_Homo sapiens_hsa005620.22294422
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21140397
99Colorectal cancer_Homo sapiens_hsa052100.21129831
100Herpes simplex infection_Homo sapiens_hsa051680.20189466

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