Rank | Gene Set | Z-score |
---|---|---|
1 | snRNA transcription (GO:0009301) | 8.50294541 |
2 | negative regulation of epidermal growth factor-activated receptor activity (GO:0007175) | 7.00578486 |
3 | negative regulation of receptor activity (GO:2000272) | 6.45817649 |
4 | positive regulation of lipoprotein lipase activity (GO:0051006) | 6.25587483 |
5 | positive regulation of triglyceride lipase activity (GO:0061365) | 6.25587483 |
6 | deoxyribonucleotide catabolic process (GO:0009264) | 5.24029806 |
7 | phosphorelay signal transduction system (GO:0000160) | 5.16336155 |
8 | keratinocyte development (GO:0003334) | 4.98097340 |
9 | deoxyribose phosphate catabolic process (GO:0046386) | 4.71337517 |
10 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 4.56068180 |
11 | multicellular organism reproduction (GO:0032504) | 4.51677295 |
12 | sulfur amino acid catabolic process (GO:0000098) | 4.47130590 |
13 | negative regulation of cAMP-mediated signaling (GO:0043951) | 4.45935398 |
14 | oocyte development (GO:0048599) | 4.28702170 |
15 | regulation of female gonad development (GO:2000194) | 4.26567277 |
16 | deoxyribose phosphate metabolic process (GO:0019692) | 4.22193554 |
17 | negative regulation of protein tyrosine kinase activity (GO:0061099) | 4.21447354 |
18 | DNA deamination (GO:0045006) | 4.11675584 |
19 | positive regulation of sodium ion transmembrane transporter activity (GO:2000651) | 4.04850472 |
20 | histone-serine phosphorylation (GO:0035404) | 4.03135997 |
21 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.03026728 |
22 | respiratory chain complex IV assembly (GO:0008535) | 4.02070495 |
23 | DNA damage response, detection of DNA damage (GO:0042769) | 3.87306451 |
24 | deoxyribonucleotide metabolic process (GO:0009262) | 3.81220560 |
25 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.73788423 |
26 | peptidyl-histidine modification (GO:0018202) | 3.73642096 |
27 | rRNA catabolic process (GO:0016075) | 3.69877275 |
28 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.66949678 |
29 | L-methionine salvage (GO:0071267) | 3.65144271 |
30 | L-methionine biosynthetic process (GO:0071265) | 3.65144271 |
31 | amino acid salvage (GO:0043102) | 3.65144271 |
32 | positive regulation of sodium ion transmembrane transport (GO:1902307) | 3.63230502 |
33 | single strand break repair (GO:0000012) | 3.62871106 |
34 | plasma lipoprotein particle clearance (GO:0034381) | 3.62051920 |
35 | regulation of DNA methylation (GO:0044030) | 3.58337445 |
36 | intestinal cholesterol absorption (GO:0030299) | 3.55415917 |
37 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.52448066 |
38 | nodal signaling pathway (GO:0038092) | 3.51758477 |
39 | somite rostral/caudal axis specification (GO:0032525) | 3.48979686 |
40 | female gamete generation (GO:0007292) | 3.46363735 |
41 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 3.44782534 |
42 | negative regulation of hormone biosynthetic process (GO:0032353) | 3.37532811 |
43 | maturation of 5.8S rRNA (GO:0000460) | 3.36815079 |
44 | regulation of cilium movement (GO:0003352) | 3.34401922 |
45 | nonmotile primary cilium assembly (GO:0035058) | 3.34189206 |
46 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.28564210 |
47 | cAMP catabolic process (GO:0006198) | 3.25425357 |
48 | atrial cardiac muscle cell action potential (GO:0086014) | 3.23758942 |
49 | negative regulation of response to food (GO:0032096) | 3.21399301 |
50 | negative regulation of appetite (GO:0032099) | 3.21399301 |
51 | SMAD protein complex assembly (GO:0007183) | 3.19547817 |
52 | base-excision repair, AP site formation (GO:0006285) | 3.18543519 |
53 | establishment of melanosome localization (GO:0032401) | 3.12817898 |
54 | regulation of acrosome reaction (GO:0060046) | 3.11422615 |
55 | melanosome transport (GO:0032402) | 3.08495896 |
56 | regulation of triglyceride metabolic process (GO:0090207) | 3.07363911 |
57 | rRNA modification (GO:0000154) | 3.06362634 |
58 | cytidine deamination (GO:0009972) | 3.04365791 |
59 | cytidine metabolic process (GO:0046087) | 3.04365791 |
60 | cytidine catabolic process (GO:0006216) | 3.04365791 |
61 | DNA integration (GO:0015074) | 3.02883926 |
62 | pyrimidine nucleotide catabolic process (GO:0006244) | 2.99410190 |
63 | aerobic respiration (GO:0009060) | 2.99106648 |
64 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.98253488 |
65 | nucleoside transmembrane transport (GO:1901642) | 2.97907161 |
66 | transcription from RNA polymerase III promoter (GO:0006383) | 2.95998694 |
67 | histone H2A acetylation (GO:0043968) | 2.93673768 |
68 | regulation of energy homeostasis (GO:2000505) | 2.93166193 |
69 | establishment of pigment granule localization (GO:0051905) | 2.92548899 |
70 | histone mRNA catabolic process (GO:0071044) | 2.91861770 |
71 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.91653408 |
72 | sensory perception of smell (GO:0007608) | 2.91575542 |
73 | rRNA methylation (GO:0031167) | 2.89899752 |
74 | purine-containing compound salvage (GO:0043101) | 2.89512520 |
75 | oxidative phosphorylation (GO:0006119) | 2.88950976 |
76 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 2.88410659 |
77 | brain morphogenesis (GO:0048854) | 2.88328759 |
78 | pigment granule transport (GO:0051904) | 2.87502033 |
79 | left/right axis specification (GO:0070986) | 2.87214744 |
80 | negative regulation of T cell differentiation in thymus (GO:0033085) | 2.86167246 |
81 | purine deoxyribonucleotide metabolic process (GO:0009151) | 2.85775926 |
82 | regulation of mitotic spindle organization (GO:0060236) | 2.85663059 |
83 | negative regulation of androgen receptor signaling pathway (GO:0060766) | 2.84598191 |
84 | cartilage morphogenesis (GO:0060536) | 2.82509748 |
85 | meiotic cell cycle (GO:0051321) | 2.81136353 |
86 | behavioral response to ethanol (GO:0048149) | 2.78766693 |
87 | cyclic nucleotide catabolic process (GO:0009214) | 2.78631981 |
88 | single fertilization (GO:0007338) | 2.78401288 |
89 | reproduction (GO:0000003) | 2.77715946 |
90 | artery smooth muscle contraction (GO:0014824) | 2.77511584 |
91 | regulation of exit from mitosis (GO:0007096) | 2.75860263 |
92 | histone H3-K36 demethylation (GO:0070544) | 2.75429519 |
93 | positive regulation of transcription from RNA polymerase III promoter (GO:0045945) | 2.74837684 |
94 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.74400960 |
95 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.74400960 |
96 | negative regulation of hormone metabolic process (GO:0032351) | 2.73386413 |
97 | cytochrome complex assembly (GO:0017004) | 2.70214293 |
98 | regulation of spindle organization (GO:0090224) | 2.67235749 |
99 | negative regulation of protein autophosphorylation (GO:0031953) | 2.66909656 |
100 | microtubule anchoring (GO:0034453) | 2.63443273 |
Rank | Gene Set | Z-score |
---|---|---|
1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.76628488 |
2 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 5.92439703 |
3 | IGF1R_20145208_ChIP-Seq_DFB_Human | 4.69651468 |
4 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 3.94425885 |
5 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 3.25898014 |
6 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 3.04934781 |
7 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.98474192 |
8 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 2.49575278 |
9 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.45967737 |
10 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.31711423 |
11 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.29834782 |
12 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.28082124 |
13 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.27644089 |
14 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.26082468 |
15 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.12408537 |
16 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.94227084 |
17 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.91232828 |
18 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.90440185 |
19 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.87372966 |
20 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.85360762 |
21 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.84964563 |
22 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.84964563 |
23 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.78897189 |
24 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.72552957 |
25 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.72065716 |
26 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.65146912 |
27 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.62395930 |
28 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.57733785 |
29 | EWS_26573619_Chip-Seq_HEK293_Human | 1.54631167 |
30 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.48761194 |
31 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.47372695 |
32 | VDR_22108803_ChIP-Seq_LS180_Human | 1.43271988 |
33 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.42121560 |
34 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.40983976 |
35 | P300_19829295_ChIP-Seq_ESCs_Human | 1.38527147 |
36 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.35276652 |
37 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.27499497 |
38 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.27499497 |
39 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.27026318 |
40 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.26243468 |
41 | TCF4_23295773_ChIP-Seq_U87_Human | 1.26056188 |
42 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.25786803 |
43 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.24568873 |
44 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.22361078 |
45 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.22292643 |
46 | STAT3_23295773_ChIP-Seq_U87_Human | 1.20627361 |
47 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.19480872 |
48 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.17021609 |
49 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.14072244 |
50 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.14040655 |
51 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.13197171 |
52 | AR_20517297_ChIP-Seq_VCAP_Human | 1.12901614 |
53 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.12683100 |
54 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.10813086 |
55 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.09834154 |
56 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.09352422 |
57 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.06680829 |
58 | GATA3_26560356_Chip-Seq_TH2_Human | 1.03837203 |
59 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.02881633 |
60 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.00881173 |
61 | SMRT_27268052_Chip-Seq_Bcells_Human | 1.00826898 |
62 | ERA_21632823_ChIP-Seq_H3396_Human | 1.00773475 |
63 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.00656117 |
64 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.00275482 |
65 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.99733354 |
66 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.99519681 |
67 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.98680366 |
68 | AR_25329375_ChIP-Seq_VCAP_Human | 0.98495818 |
69 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.97402678 |
70 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.96495026 |
71 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 0.95571497 |
72 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.94499515 |
73 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.94425680 |
74 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.93544525 |
75 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.93544525 |
76 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.92773543 |
77 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 0.92265760 |
78 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.91813758 |
79 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.90735387 |
80 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.90633269 |
81 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.90358329 |
82 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.90184268 |
83 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.89374771 |
84 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.89174745 |
85 | FUS_26573619_Chip-Seq_HEK293_Human | 0.87973607 |
86 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.87959282 |
87 | KDM2B_26808549_Chip-Seq_REH_Human | 0.86972209 |
88 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.85057881 |
89 | FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.84727154 |
90 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 0.83756097 |
91 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.83611840 |
92 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.83451200 |
93 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.81683129 |
94 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.81305493 |
95 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.81232101 |
96 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.79925327 |
97 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.79767025 |
98 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.79330527 |
99 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.79072941 |
100 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.78116877 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0001661_extended_life_span | 4.93355645 |
2 | MP0003890_abnormal_embryonic-extraembry | 4.21612720 |
3 | MP0003718_maternal_effect | 4.20737539 |
4 | MP0008789_abnormal_olfactory_epithelium | 3.85257597 |
5 | MP0005499_abnormal_olfactory_system | 3.33713251 |
6 | MP0005394_taste/olfaction_phenotype | 3.33713251 |
7 | MP0000569_abnormal_digit_pigmentation | 3.15952910 |
8 | MP0000427_abnormal_hair_cycle | 2.51846140 |
9 | MP0002160_abnormal_reproductive_system | 2.40237703 |
10 | MP0003045_fibrosis | 2.32186813 |
11 | MP0008057_abnormal_DNA_replication | 2.23253369 |
12 | MP0005646_abnormal_pituitary_gland | 2.20678166 |
13 | MP0001986_abnormal_taste_sensitivity | 2.18241915 |
14 | MP0002295_abnormal_pulmonary_circulatio | 2.15297198 |
15 | MP0003646_muscle_fatigue | 2.11646258 |
16 | MP0008877_abnormal_DNA_methylation | 2.08690926 |
17 | MP0005395_other_phenotype | 2.05702503 |
18 | MP0005266_abnormal_metabolism | 2.03670777 |
19 | MP0003693_abnormal_embryo_hatching | 1.98909559 |
20 | MP0001968_abnormal_touch/_nociception | 1.91350696 |
21 | MP0004145_abnormal_muscle_electrophysio | 1.77451211 |
22 | MP0010307_abnormal_tumor_latency | 1.75450935 |
23 | MP0001764_abnormal_homeostasis | 1.68119499 |
24 | MP0005551_abnormal_eye_electrophysiolog | 1.66850538 |
25 | MP0001727_abnormal_embryo_implantation | 1.62326189 |
26 | MP0001984_abnormal_olfaction | 1.60047021 |
27 | MP0005389_reproductive_system_phenotype | 1.55054015 |
28 | MP0003195_calcinosis | 1.54206024 |
29 | MP0004133_heterotaxia | 1.51759147 |
30 | MP0003959_abnormal_lean_body | 1.51162603 |
31 | MP0001529_abnormal_vocalization | 1.48195293 |
32 | MP0009278_abnormal_bone_marrow | 1.47948669 |
33 | MP0005253_abnormal_eye_physiology | 1.46985736 |
34 | MP0005647_abnormal_sex_gland | 1.45060822 |
35 | MP0003786_premature_aging | 1.45019501 |
36 | MP0001929_abnormal_gametogenesis | 1.44972784 |
37 | MP0005360_urolithiasis | 1.43942261 |
38 | MP0006292_abnormal_olfactory_placode | 1.43842660 |
39 | MP0010352_gastrointestinal_tract_polyps | 1.36494650 |
40 | MP0003172_abnormal_lysosome_physiology | 1.35481481 |
41 | MP0005084_abnormal_gallbladder_morpholo | 1.33504484 |
42 | MP0006036_abnormal_mitochondrial_physio | 1.33157908 |
43 | MP0004510_myositis | 1.32162786 |
44 | MP0009697_abnormal_copulation | 1.31012840 |
45 | MP0002282_abnormal_trachea_morphology | 1.30189023 |
46 | MP0009384_cardiac_valve_regurgitation | 1.29325499 |
47 | MP0005376_homeostasis/metabolism_phenot | 1.28604813 |
48 | MP0005410_abnormal_fertilization | 1.27941773 |
49 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.25656565 |
50 | MP0005645_abnormal_hypothalamus_physiol | 1.22888724 |
51 | MP0001119_abnormal_female_reproductive | 1.20328634 |
52 | MP0003950_abnormal_plasma_membrane | 1.19353310 |
53 | MP0002277_abnormal_respiratory_mucosa | 1.13194788 |
54 | MP0003699_abnormal_female_reproductive | 1.10880777 |
55 | MP0000653_abnormal_sex_gland | 1.10652257 |
56 | MP0002210_abnormal_sex_determination | 1.09275673 |
57 | MP0009333_abnormal_splenocyte_physiolog | 1.08735477 |
58 | MP0001501_abnormal_sleep_pattern | 1.08315176 |
59 | MP0001944_abnormal_pancreas_morphology | 1.07976075 |
60 | MP0003252_abnormal_bile_duct | 1.05714454 |
61 | MP0001485_abnormal_pinna_reflex | 1.05411059 |
62 | MP0002693_abnormal_pancreas_physiology | 1.04894173 |
63 | MP0005670_abnormal_white_adipose | 1.04301662 |
64 | MP0000470_abnormal_stomach_morphology | 0.98414587 |
65 | MP0000631_abnormal_neuroendocrine_gland | 0.98293793 |
66 | MP0000749_muscle_degeneration | 0.94039692 |
67 | MP0005391_vision/eye_phenotype | 0.85783672 |
68 | MP0008775_abnormal_heart_ventricle | 0.83679588 |
69 | MP0002161_abnormal_fertility/fecundity | 0.83206404 |
70 | MP0002928_abnormal_bile_duct | 0.79249372 |
71 | MP0008058_abnormal_DNA_repair | 0.78205727 |
72 | MP0002233_abnormal_nose_morphology | 0.77675350 |
73 | MP0005636_abnormal_mineral_homeostasis | 0.76619316 |
74 | MP0002168_other_aberrant_phenotype | 0.76332182 |
75 | MP0002733_abnormal_thermal_nociception | 0.75427598 |
76 | MP0002249_abnormal_larynx_morphology | 0.75382760 |
77 | MP0002111_abnormal_tail_morphology | 0.72225032 |
78 | MP0005448_abnormal_energy_balance | 0.71825375 |
79 | MP0001542_abnormal_bone_strength | 0.71788820 |
80 | MP0001664_abnormal_digestion | 0.71631350 |
81 | MP0010329_abnormal_lipoprotein_level | 0.67025208 |
82 | MP0005379_endocrine/exocrine_gland_phen | 0.66315832 |
83 | MP0002163_abnormal_gland_morphology | 0.66223673 |
84 | MP0003698_abnormal_male_reproductive | 0.66112076 |
85 | MP0009764_decreased_sensitivity_to | 0.64623238 |
86 | MP0002735_abnormal_chemical_nociception | 0.64289869 |
87 | MP0005452_abnormal_adipose_tissue | 0.63991177 |
88 | MP0001324_abnormal_eye_pigmentation | 0.63933281 |
89 | MP0005397_hematopoietic_system_phenotyp | 0.63600330 |
90 | MP0001545_abnormal_hematopoietic_system | 0.63600330 |
91 | MP0001730_embryonic_growth_arrest | 0.63264370 |
92 | MP0001145_abnormal_male_reproductive | 0.62928866 |
93 | MP0002132_abnormal_respiratory_system | 0.59510197 |
94 | MP0005195_abnormal_posterior_eye | 0.59508534 |
95 | MP0004043_abnormal_pH_regulation | 0.58842004 |
96 | MP0005671_abnormal_response_to | 0.57889110 |
97 | MP0006276_abnormal_autonomic_nervous | 0.56658496 |
98 | MP0005085_abnormal_gallbladder_physiolo | 0.56186798 |
99 | MP0002118_abnormal_lipid_homeostasis | 0.55682270 |
100 | MP0004197_abnormal_fetal_growth/weight/ | 0.55280566 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Hepatocellular necrosis (HP:0001404) | 5.18738485 |
2 | Hepatic necrosis (HP:0002605) | 5.05857331 |
3 | Molar tooth sign on MRI (HP:0002419) | 4.49303139 |
4 | Abnormality of midbrain morphology (HP:0002418) | 4.49303139 |
5 | Hypothermia (HP:0002045) | 4.39427079 |
6 | Abnormality of abdominal situs (HP:0011620) | 4.10883811 |
7 | Abdominal situs inversus (HP:0003363) | 4.10883811 |
8 | Generalized aminoaciduria (HP:0002909) | 3.83050890 |
9 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.78178237 |
10 | Conjunctival telangiectasia (HP:0000524) | 3.67824580 |
11 | Colon cancer (HP:0003003) | 3.54020691 |
12 | Abnormality of alanine metabolism (HP:0010916) | 3.51596150 |
13 | Hyperalaninemia (HP:0003348) | 3.51596150 |
14 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.51596150 |
15 | Spontaneous hematomas (HP:0007420) | 3.37393123 |
16 | Hypoplastic iliac wings (HP:0002866) | 3.18818726 |
17 | Hydroureter (HP:0000072) | 3.18673867 |
18 | Broad ribs (HP:0000885) | 3.18569084 |
19 | Medial flaring of the eyebrow (HP:0010747) | 3.18110809 |
20 | Adactyly (HP:0009776) | 3.05963373 |
21 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 3.04979353 |
22 | Congenital primary aphakia (HP:0007707) | 3.02043326 |
23 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.00087593 |
24 | Abnormality of the renal cortex (HP:0011035) | 2.98947265 |
25 | Mitochondrial inheritance (HP:0001427) | 2.96548960 |
26 | Poor coordination (HP:0002370) | 2.91258190 |
27 | Renal cortical cysts (HP:0000803) | 2.88449759 |
28 | Gait imbalance (HP:0002141) | 2.86227006 |
29 | Increased CSF lactate (HP:0002490) | 2.81757802 |
30 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.77618089 |
31 | High anterior hairline (HP:0009890) | 2.74716103 |
32 | Microretrognathia (HP:0000308) | 2.72748914 |
33 | Pendular nystagmus (HP:0012043) | 2.72341855 |
34 | Hyperglycinuria (HP:0003108) | 2.65261761 |
35 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.62243989 |
36 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.62243989 |
37 | Portal hypertension (HP:0001409) | 2.61587806 |
38 | Chronic hepatic failure (HP:0100626) | 2.58313507 |
39 | Pancreatic cysts (HP:0001737) | 2.58143936 |
40 | Chronic diarrhea (HP:0002028) | 2.53613748 |
41 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.51642830 |
42 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.51642830 |
43 | Abnormal protein glycosylation (HP:0012346) | 2.51642830 |
44 | Abnormal glycosylation (HP:0012345) | 2.51642830 |
45 | Pancreatic fibrosis (HP:0100732) | 2.50907132 |
46 | Aplasia/Hypoplasia of the nipples (HP:0006709) | 2.49834191 |
47 | Nephrogenic diabetes insipidus (HP:0009806) | 2.48474119 |
48 | Petechiae (HP:0000967) | 2.42220229 |
49 | Abnormality of the hepatic vasculature (HP:0006707) | 2.40255548 |
50 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.39878887 |
51 | Hypoplasia of the fovea (HP:0007750) | 2.39878887 |
52 | Nephronophthisis (HP:0000090) | 2.38770505 |
53 | Bony spicule pigmentary retinopathy (HP:0007737) | 2.38104904 |
54 | Acute encephalopathy (HP:0006846) | 2.37856367 |
55 | Respiratory failure (HP:0002878) | 2.34576070 |
56 | Median cleft lip (HP:0000161) | 2.33859211 |
57 | Acute necrotizing encephalopathy (HP:0006965) | 2.32392686 |
58 | Sclerocornea (HP:0000647) | 2.29983899 |
59 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.26068368 |
60 | Septate vagina (HP:0001153) | 2.24010780 |
61 | Congenital hepatic fibrosis (HP:0002612) | 2.23823992 |
62 | Disproportionate short-trunk short stature (HP:0003521) | 2.22539070 |
63 | Metaphyseal irregularity (HP:0003025) | 2.22228493 |
64 | Hematochezia (HP:0002573) | 2.21346127 |
65 | Highly arched eyebrow (HP:0002553) | 2.19835944 |
66 | 3-Methylglutaconic aciduria (HP:0003535) | 2.19269665 |
67 | Abnormality of the renal medulla (HP:0100957) | 2.18514718 |
68 | Supernumerary spleens (HP:0009799) | 2.17340246 |
69 | Short tibia (HP:0005736) | 2.16888226 |
70 | Rectal prolapse (HP:0002035) | 2.16520057 |
71 | Progressive macrocephaly (HP:0004481) | 2.16099915 |
72 | Attenuation of retinal blood vessels (HP:0007843) | 2.12772852 |
73 | True hermaphroditism (HP:0010459) | 2.12588215 |
74 | Truncal obesity (HP:0001956) | 2.11691685 |
75 | Preaxial hand polydactyly (HP:0001177) | 2.10041939 |
76 | CNS demyelination (HP:0007305) | 2.09357030 |
77 | Oligodactyly (hands) (HP:0001180) | 2.08636497 |
78 | Abnormality of the basal ganglia (HP:0002134) | 2.05508256 |
79 | Genital tract atresia (HP:0001827) | 2.04663659 |
80 | Abnormality of the columella (HP:0009929) | 2.02848636 |
81 | Lactic acidosis (HP:0003128) | 2.00881328 |
82 | Abnormality of the fovea (HP:0000493) | 1.95397386 |
83 | Hip dysplasia (HP:0001385) | 1.92113421 |
84 | Hypoglycemic coma (HP:0001325) | 1.91112748 |
85 | Abolished electroretinogram (ERG) (HP:0000550) | 1.90995829 |
86 | Abnormality of DNA repair (HP:0003254) | 1.90503361 |
87 | Hypoalbuminemia (HP:0003073) | 1.85982032 |
88 | Abnormal albumin level (HP:0012116) | 1.85982032 |
89 | Vaginal atresia (HP:0000148) | 1.85329565 |
90 | Flared iliac wings (HP:0002869) | 1.84592396 |
91 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.81935955 |
92 | Microcytic anemia (HP:0001935) | 1.81644847 |
93 | Vitreoretinal degeneration (HP:0000655) | 1.81549162 |
94 | Postaxial foot polydactyly (HP:0001830) | 1.80449902 |
95 | Chorioretinal atrophy (HP:0000533) | 1.77858203 |
96 | Hypoplasia of the uterus (HP:0000013) | 1.77825784 |
97 | Tarsal synostosis (HP:0008368) | 1.77296517 |
98 | Oculomotor apraxia (HP:0000657) | 1.76173570 |
99 | Autoimmune thrombocytopenia (HP:0001973) | 1.74020502 |
100 | Rectal fistula (HP:0100590) | 1.70064986 |
Rank | Gene Set | Z-score |
---|---|---|
1 | NEK9 | 4.58516256 |
2 | ADRBK2 | 4.37882988 |
3 | NUAK1 | 3.88918145 |
4 | BMPR1B | 3.17727392 |
5 | NLK | 2.79690107 |
6 | DAPK2 | 2.76551337 |
7 | INSRR | 2.72154081 |
8 | MAP3K13 | 2.61893760 |
9 | FRK | 2.46193586 |
10 | MAP3K4 | 2.40531767 |
11 | STK24 | 2.39300461 |
12 | BUB1 | 2.31537059 |
13 | NME1 | 2.19919754 |
14 | TNK2 | 2.17493133 |
15 | MAP3K7 | 1.94513426 |
16 | IRAK1 | 1.93792613 |
17 | NTRK3 | 1.90027632 |
18 | STK3 | 1.69365402 |
19 | CAMKK2 | 1.58679662 |
20 | STK38L | 1.57520856 |
21 | MST4 | 1.52735935 |
22 | PTK2B | 1.46272828 |
23 | CHUK | 1.42623334 |
24 | MELK | 1.42540870 |
25 | TEC | 1.40813451 |
26 | CDC7 | 1.36291058 |
27 | BRSK2 | 1.32714077 |
28 | TAOK3 | 1.28113769 |
29 | ACVR1B | 1.20867721 |
30 | MAP3K9 | 1.20259501 |
31 | ARAF | 1.17547692 |
32 | TRIM28 | 1.15847234 |
33 | PDK2 | 1.08213891 |
34 | TXK | 1.08158834 |
35 | GRK1 | 1.03458458 |
36 | PNCK | 0.98807618 |
37 | PRKAA2 | 0.95686010 |
38 | EIF2AK3 | 0.93198960 |
39 | CAMK1D | 0.90765276 |
40 | STK11 | 0.90052570 |
41 | MAP4K2 | 0.86800577 |
42 | IKBKB | 0.86398145 |
43 | CAMK1G | 0.82404316 |
44 | CSNK1A1L | 0.80793603 |
45 | PIK3CA | 0.79933408 |
46 | PASK | 0.76481558 |
47 | CDK9 | 0.75111857 |
48 | IRAK4 | 0.74790762 |
49 | PAK3 | 0.73624909 |
50 | CDK8 | 0.72266664 |
51 | CAMK4 | 0.72071836 |
52 | PIK3CG | 0.69855714 |
53 | MAPKAPK5 | 0.69461634 |
54 | TNIK | 0.68705011 |
55 | ITK | 0.67364116 |
56 | DYRK1A | 0.67100787 |
57 | ADRBK1 | 0.66937677 |
58 | IRAK2 | 0.65699198 |
59 | DYRK3 | 0.65579488 |
60 | RAF1 | 0.65483978 |
61 | BTK | 0.63180878 |
62 | TRPM7 | 0.63095197 |
63 | CSNK1G3 | 0.62602640 |
64 | CSNK1G1 | 0.62209709 |
65 | MAP3K1 | 0.60904368 |
66 | PRKCG | 0.60610352 |
67 | WEE1 | 0.58103814 |
68 | TGFBR1 | 0.57926742 |
69 | MAP4K1 | 0.56779278 |
70 | MAPKAPK3 | 0.55593180 |
71 | BRSK1 | 0.52672779 |
72 | MAP2K2 | 0.52630134 |
73 | VRK1 | 0.51765019 |
74 | OXSR1 | 0.49199508 |
75 | MAP2K7 | 0.48669388 |
76 | CAMK2A | 0.47290996 |
77 | CDK12 | 0.46154724 |
78 | LATS1 | 0.45253989 |
79 | IKBKE | 0.44384386 |
80 | BLK | 0.44240781 |
81 | MAP2K4 | 0.42853160 |
82 | VRK2 | 0.42461453 |
83 | CSNK1G2 | 0.42373524 |
84 | CASK | 0.41205010 |
85 | CDK7 | 0.40179495 |
86 | NEK6 | 0.40137319 |
87 | PRKCE | 0.39549779 |
88 | MAPK15 | 0.39532901 |
89 | CSNK1E | 0.38753549 |
90 | PLK1 | 0.36541885 |
91 | AKT2 | 0.36511527 |
92 | PLK4 | 0.34883471 |
93 | AKT1 | 0.32769342 |
94 | PRKCQ | 0.32214431 |
95 | PRKAA1 | 0.32016001 |
96 | PRKD3 | 0.31033763 |
97 | DAPK1 | 0.31006254 |
98 | PRKG1 | 0.29903270 |
99 | CHEK1 | 0.28549156 |
100 | YES1 | 0.28495228 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Sulfur metabolism_Homo sapiens_hsa00920 | 7.36673217 |
2 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 4.37996365 |
3 | Protein export_Homo sapiens_hsa03060 | 3.93127539 |
4 | RNA polymerase_Homo sapiens_hsa03020 | 2.95057392 |
5 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 2.45766493 |
6 | Folate biosynthesis_Homo sapiens_hsa00790 | 2.42015045 |
7 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.40054959 |
8 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 2.10321830 |
9 | Basal transcription factors_Homo sapiens_hsa03022 | 2.07198844 |
10 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.88356001 |
11 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.83709720 |
12 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.72144009 |
13 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.55440957 |
14 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.55275740 |
15 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.53657402 |
16 | Base excision repair_Homo sapiens_hsa03410 | 1.50549418 |
17 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.42970099 |
18 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.40089734 |
19 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.38609749 |
20 | Parkinsons disease_Homo sapiens_hsa05012 | 1.36963595 |
21 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.35717677 |
22 | Homologous recombination_Homo sapiens_hsa03440 | 1.33832748 |
23 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.28228697 |
24 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.27234713 |
25 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.27146969 |
26 | Huntingtons disease_Homo sapiens_hsa05016 | 1.27097531 |
27 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.23278768 |
28 | RNA degradation_Homo sapiens_hsa03018 | 1.18638179 |
29 | Circadian rhythm_Homo sapiens_hsa04710 | 1.17890150 |
30 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.09771565 |
31 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.06466830 |
32 | Morphine addiction_Homo sapiens_hsa05032 | 1.02218537 |
33 | Mismatch repair_Homo sapiens_hsa03430 | 1.02061927 |
34 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.01820054 |
35 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 1.00256012 |
36 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.97052895 |
37 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.91006002 |
38 | Cell cycle_Homo sapiens_hsa04110 | 0.88025002 |
39 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.86113529 |
40 | Alzheimers disease_Homo sapiens_hsa05010 | 0.85666328 |
41 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.84419421 |
42 | Taste transduction_Homo sapiens_hsa04742 | 0.81516547 |
43 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.81102831 |
44 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.80838220 |
45 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.80510058 |
46 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.79382291 |
47 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.79163252 |
48 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.77885524 |
49 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.76833693 |
50 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.75757796 |
51 | Purine metabolism_Homo sapiens_hsa00230 | 0.75738523 |
52 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.75527695 |
53 | ABC transporters_Homo sapiens_hsa02010 | 0.72718947 |
54 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.71614335 |
55 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.71014598 |
56 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.69237969 |
57 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.68577968 |
58 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.65213994 |
59 | Retinol metabolism_Homo sapiens_hsa00830 | 0.60594031 |
60 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.58017277 |
61 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.57741487 |
62 | Olfactory transduction_Homo sapiens_hsa04740 | 0.56627637 |
63 | Mineral absorption_Homo sapiens_hsa04978 | 0.55997401 |
64 | Lysine degradation_Homo sapiens_hsa00310 | 0.55847076 |
65 | RNA transport_Homo sapiens_hsa03013 | 0.54496942 |
66 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.53692901 |
67 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.53052961 |
68 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.49557653 |
69 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.47854289 |
70 | Proteasome_Homo sapiens_hsa03050 | 0.47040048 |
71 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.46859404 |
72 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.46607589 |
73 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.46497328 |
74 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.45893716 |
75 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.42325061 |
76 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.42192500 |
77 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.40685034 |
78 | Measles_Homo sapiens_hsa05162 | 0.40556314 |
79 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.38871236 |
80 | Phototransduction_Homo sapiens_hsa04744 | 0.37173448 |
81 | Insulin secretion_Homo sapiens_hsa04911 | 0.36671831 |
82 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.35336817 |
83 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.34698842 |
84 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.34644978 |
85 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.31530249 |
86 | Nicotine addiction_Homo sapiens_hsa05033 | 0.31316610 |
87 | Metabolic pathways_Homo sapiens_hsa01100 | 0.31162273 |
88 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.30891274 |
89 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.29494557 |
90 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.28344188 |
91 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.27680793 |
92 | Hepatitis B_Homo sapiens_hsa05161 | 0.26112595 |
93 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.26101864 |
94 | Circadian entrainment_Homo sapiens_hsa04713 | 0.24568703 |
95 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.24104046 |
96 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.23902813 |
97 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.22294422 |
98 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.21140397 |
99 | Colorectal cancer_Homo sapiens_hsa05210 | 0.21129831 |
100 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.20189466 |