HTR6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication checkpoint (GO:0000076)6.63152582
2pharyngeal system development (GO:0060037)6.53006330
3muscle cell fate commitment (GO:0042693)6.32588213
4N-glycan processing (GO:0006491)6.02509996
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.95378781
6vocalization behavior (GO:0071625)5.68395997
7regulation of short-term neuronal synaptic plasticity (GO:0048172)5.65399107
8mucosal-associated lymphoid tissue development (GO:0048537)5.62559577
9Peyers patch development (GO:0048541)5.62559577
10formation of translation preinitiation complex (GO:0001731)5.56837600
11ionotropic glutamate receptor signaling pathway (GO:0035235)5.34082304
12mature B cell differentiation involved in immune response (GO:0002313)5.32174807
13ribosome assembly (GO:0042255)5.28801379
14protein localization to synapse (GO:0035418)5.23507711
15locomotory exploration behavior (GO:0035641)5.18912780
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.15035323
17regulation of membrane lipid distribution (GO:0097035)5.12386921
18synaptic vesicle maturation (GO:0016188)5.11646021
19glutamate receptor signaling pathway (GO:0007215)4.93434576
20mature B cell differentiation (GO:0002335)4.76076240
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.74461259
22neuron cell-cell adhesion (GO:0007158)4.65074567
23regulation of synaptic vesicle exocytosis (GO:2000300)4.64305295
24regulation of glutamate receptor signaling pathway (GO:1900449)4.64084613
25synaptic transmission, glutamatergic (GO:0035249)4.57817675
26synaptic vesicle exocytosis (GO:0016079)4.56374409
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.52161656
28glutamate secretion (GO:0014047)4.50151463
29neuron-neuron synaptic transmission (GO:0007270)4.49779239
30regulation of chromatin binding (GO:0035561)4.44254601
31regulation of neuronal synaptic plasticity (GO:0048168)4.39852916
32negative regulation of erythrocyte differentiation (GO:0045647)4.37093933
33positive regulation of RNA splicing (GO:0033120)4.34555591
34atrial septum morphogenesis (GO:0060413)4.32737001
35epithelial cell fate commitment (GO:0072148)4.32126636
36neurotransmitter-gated ion channel clustering (GO:0072578)4.31917303
37regulation of histone H3-K27 methylation (GO:0061085)4.25717181
38exploration behavior (GO:0035640)4.25355755
39cullin deneddylation (GO:0010388)4.20438379
40positive thymic T cell selection (GO:0045059)4.19374037
41regulation of synaptic vesicle transport (GO:1902803)4.12791792
42branched-chain amino acid catabolic process (GO:0009083)4.11764423
43intestinal epithelial cell development (GO:0060576)4.11487204
44prepulse inhibition (GO:0060134)4.06723274
45regulation of excitatory postsynaptic membrane potential (GO:0060079)4.04329540
46negative regulation of synaptic transmission, GABAergic (GO:0032229)4.02624670
47negative regulation of protein tyrosine kinase activity (GO:0061099)4.01835365
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.99684588
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.98776219
50long-term memory (GO:0007616)3.98654806
51regulation of B cell receptor signaling pathway (GO:0050855)3.97216671
52neurotransmitter secretion (GO:0007269)3.96001280
53positive regulation of membrane potential (GO:0045838)3.94186085
54outer ear morphogenesis (GO:0042473)3.93902639
55synaptic vesicle docking involved in exocytosis (GO:0016081)3.93843410
56postsynaptic membrane organization (GO:0001941)3.92521184
57behavioral response to cocaine (GO:0048148)3.90999005
58dendritic spine morphogenesis (GO:0060997)3.88726507
59histone H4-K5 acetylation (GO:0043981)3.87007643
60histone H4-K8 acetylation (GO:0043982)3.87007643
61* long-term synaptic potentiation (GO:0060291)3.83348121
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.82950372
63thymic T cell selection (GO:0045061)3.82591013
64regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.82269632
65post-embryonic morphogenesis (GO:0009886)3.80071139
66transmission of nerve impulse (GO:0019226)3.79481060
67regulation of dendritic spine morphogenesis (GO:0061001)3.78412453
68neuronal action potential propagation (GO:0019227)3.78312042
69* regulation of glutamate secretion (GO:0014048)3.76870871
70regulation of mammary gland epithelial cell proliferation (GO:0033599)3.76648284
71* regulation of synaptic plasticity (GO:0048167)3.76186240
72striatum development (GO:0021756)3.75388291
73regulation of postsynaptic membrane potential (GO:0060078)3.74640885
74layer formation in cerebral cortex (GO:0021819)3.70861541
75actin filament capping (GO:0051693)3.70417685
76protein deneddylation (GO:0000338)3.65630300
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.64091762
78urogenital system development (GO:0001655)3.63359468
79positive regulation of synapse maturation (GO:0090129)3.62570897
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.61792992
81mitotic chromosome condensation (GO:0007076)3.60911832
82neuron recognition (GO:0008038)3.60492009
83negative regulation of activin receptor signaling pathway (GO:0032926)3.60082030
84regulation of synapse structural plasticity (GO:0051823)3.58188385
85behavioral defense response (GO:0002209)3.57879602
86behavioral fear response (GO:0001662)3.57879602
87pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.57461592
88positive regulation of synaptic transmission, GABAergic (GO:0032230)3.57229392
89microtubule nucleation (GO:0007020)3.55049594
90auditory behavior (GO:0031223)3.54383061
91proline transport (GO:0015824)3.53026200
92gamma-aminobutyric acid signaling pathway (GO:0007214)3.51832379
93* negative regulation of amino acid transport (GO:0051956)3.50106469
94presynaptic membrane assembly (GO:0097105)3.47807296
95neuronal ion channel clustering (GO:0045161)3.46395918
96regulation of cardioblast proliferation (GO:0003264)3.46045893
97regulation of secondary heart field cardioblast proliferation (GO:0003266)3.46045893
98regulation of synaptic transmission, glutamatergic (GO:0051966)3.45910913
99positive regulation of neurotransmitter secretion (GO:0001956)3.45435227
100regulation of vesicle fusion (GO:0031338)3.43353300
101positive regulation of dendritic spine morphogenesis (GO:0061003)3.42970573
102meiotic chromosome segregation (GO:0045132)3.42362474
103dendritic spine organization (GO:0097061)3.42267640
104presynaptic membrane organization (GO:0097090)3.41186455
105axonal fasciculation (GO:0007413)3.40544559
106gamma-aminobutyric acid transport (GO:0015812)3.39688006
107cerebellar granule cell differentiation (GO:0021707)3.39059166
108* learning (GO:0007612)3.37322143
109positive regulation of dendritic spine development (GO:0060999)3.36147042
110negative thymic T cell selection (GO:0045060)3.33016037
111branched-chain amino acid metabolic process (GO:0009081)3.31878669
112regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30149400
113positive regulation of granulocyte differentiation (GO:0030854)3.29722408
114mating behavior (GO:0007617)3.28917494
115regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.28195141
116regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.28195141
117histone H3-K4 trimethylation (GO:0080182)3.26283450
118positive regulation of neurotransmitter transport (GO:0051590)3.25580649
119synaptic transmission, dopaminergic (GO:0001963)3.25317949
120fear response (GO:0042596)3.23167324
121neurotransmitter transport (GO:0006836)3.22809979
122response to auditory stimulus (GO:0010996)3.21731966
123membrane depolarization (GO:0051899)3.18703932
124pathway-restricted SMAD protein phosphorylation (GO:0060389)3.18702950
125long term synaptic depression (GO:0060292)3.18134820
126positive T cell selection (GO:0043368)3.17446710
127mitotic sister chromatid segregation (GO:0000070)3.16643573
128dopamine receptor signaling pathway (GO:0007212)3.15954172
129regulation of dendritic spine development (GO:0060998)3.15378367
130regulation of neurotransmitter uptake (GO:0051580)3.13785101
131neuromuscular process controlling balance (GO:0050885)3.13515077
132negative T cell selection (GO:0043383)3.13350529
133base-excision repair, AP site formation (GO:0006285)3.12632462
134glycine transport (GO:0015816)3.12493025
135vesicle transport along microtubule (GO:0047496)3.10526084
136response to histamine (GO:0034776)3.09146344
137* positive regulation of synaptic transmission (GO:0050806)3.08496220
138CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.07703122
139histone H4-K16 acetylation (GO:0043984)3.07561101
140response to amphetamine (GO:0001975)3.06353812
141pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.06222500
142regulation of synaptic transmission, GABAergic (GO:0032228)3.04862337
143* regulation of synaptic transmission (GO:0050804)3.03695010
144regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03018562
145regulation of synapse maturation (GO:0090128)3.02833984
146* regulation of neurotransmitter secretion (GO:0046928)3.02727796
147regulation of protein kinase A signaling (GO:0010738)3.01451618
148* regulation of neurotransmitter transport (GO:0051588)2.99874348
149folic acid-containing compound biosynthetic process (GO:0009396)2.99813116
150peptidyl-threonine phosphorylation (GO:0018107)2.99136420
151phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.98477455
152synapse assembly (GO:0007416)2.98443387
153regulation of translational termination (GO:0006449)2.97861144
154negative regulation of phagocytosis (GO:0050765)2.97608933
155regulation of female receptivity (GO:0045924)2.96570111
156activation of protein kinase A activity (GO:0034199)2.96516779
157negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.96323641
158negative regulation of actin filament depolymerization (GO:0030835)2.95532518
159DNA unwinding involved in DNA replication (GO:0006268)2.93427877
160pyrimidine nucleotide catabolic process (GO:0006244)2.92244528
161termination of RNA polymerase II transcription (GO:0006369)2.86917311
162positive regulation of protein sumoylation (GO:0033235)2.85441867
163peripheral nervous system neuron development (GO:0048935)2.84170346
164T cell lineage commitment (GO:0002360)2.83709389
165aorta morphogenesis (GO:0035909)2.75940276
166T cell selection (GO:0045058)2.74421728
1673-UTR-mediated mRNA stabilization (GO:0070935)2.73751475
168mRNA export from nucleus (GO:0006406)2.72319376
169regulation of NFAT protein import into nucleus (GO:0051532)2.70427374
170early endosome to late endosome transport (GO:0045022)2.69606310
171B cell receptor signaling pathway (GO:0050853)2.69404208
172negative regulation of histone methylation (GO:0031061)2.66062755
173sister chromatid segregation (GO:0000819)2.65887336
174negative regulation of protein oligomerization (GO:0032460)2.62797558
175positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.62141250
176negative regulation of peptidyl-tyrosine phosphorylation (GO:0050732)2.62007004
177positive regulation of humoral immune response (GO:0002922)2.60883290
178peptidyl-threonine modification (GO:0018210)2.57282766
179signal complex assembly (GO:0007172)2.55179447
180positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54319751
181spliceosomal tri-snRNP complex assembly (GO:0000244)2.50830093
182positive regulation of protein kinase C signaling (GO:0090037)2.47335333
183lymph node development (GO:0048535)2.46643883
184gland morphogenesis (GO:0022612)2.46315218
185regulation of sequestering of calcium ion (GO:0051282)2.43046241
186RNA export from nucleus (GO:0006405)2.42694965
187regulation of histone H3-K9 methylation (GO:0051570)2.41582326
188regulation of heart morphogenesis (GO:2000826)2.40628626
189negative regulation of sequestering of calcium ion (GO:0051283)2.39038575
190release of sequestered calcium ion into cytosol (GO:0051209)2.39038575
191Rac protein signal transduction (GO:0016601)2.37785281
192cellular response to interleukin-15 (GO:0071350)2.35398705
193regulation of granulocyte differentiation (GO:0030852)2.35291001
194ribosomal small subunit biogenesis (GO:0042274)2.32932845
195histone H4 acetylation (GO:0043967)2.32879451
196histone deubiquitination (GO:0016578)2.32065576
197immunoglobulin mediated immune response (GO:0016064)2.30816984
198negative regulation of mRNA processing (GO:0050686)2.30391353
199phospholipid scrambling (GO:0017121)11.9170314
200mannose metabolic process (GO:0006013)10.0686627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.49460915
2MYC_22102868_ChIP-Seq_BL_Human4.77358933
3E2F7_22180533_ChIP-Seq_HELA_Human4.23547809
4GBX2_23144817_ChIP-Seq_PC3_Human3.83661835
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.81164728
6VDR_21846776_ChIP-Seq_THP-1_Human3.43974631
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.28621593
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17741884
9* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.17134542
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.81009499
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.80392185
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79689837
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79689837
14* EZH2_27304074_Chip-Seq_ESCs_Mouse2.71512859
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.71132084
16CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.70561251
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.62766565
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60124524
19* REST_21632747_ChIP-Seq_MESCs_Mouse2.57307971
20LXR_22292898_ChIP-Seq_THP-1_Human2.56373167
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54730857
22* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54559483
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54416446
24DROSHA_22980978_ChIP-Seq_HELA_Human2.52860699
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51553516
26* EED_16625203_ChIP-ChIP_MESCs_Mouse2.38386322
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.32916300
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32628655
29EZH2_27294783_Chip-Seq_ESCs_Mouse2.29271721
30KDM2B_26808549_Chip-Seq_SUP-B15_Human2.25553167
31IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22586065
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.17494127
33AR_21572438_ChIP-Seq_LNCaP_Human2.17423550
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.17351602
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14652910
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10927671
37TCF7_22412390_ChIP-Seq_EML_Mouse2.08433583
38VDR_24763502_ChIP-Seq_THP-1_Human2.07257723
39KDM2B_26808549_Chip-Seq_DND41_Human2.05420623
40MYC_18555785_ChIP-Seq_MESCs_Mouse2.02962736
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01552305
42FOXM1_23109430_ChIP-Seq_U2OS_Human2.01281635
43* REST_18959480_ChIP-ChIP_MESCs_Mouse2.01036735
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98263518
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96298456
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94373514
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92632283
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91648496
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91065258
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.90348419
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88607708
52CIITA_25753668_ChIP-Seq_RAJI_Human1.88471871
53MAF_26560356_Chip-Seq_TH1_Human1.83774515
54XRN2_22483619_ChIP-Seq_HELA_Human1.80178938
55* TET1_21451524_ChIP-Seq_MESCs_Mouse1.77271479
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72935355
57MAF_26560356_Chip-Seq_TH2_Human1.70308813
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70191189
59IRF8_21731497_ChIP-ChIP_J774_Mouse1.68589913
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67850687
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.67661566
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.64288223
63SMAD4_21799915_ChIP-Seq_A2780_Human1.63141332
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61793879
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59628215
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56223436
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.54800703
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53724768
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53661850
70* P68_20966046_ChIP-Seq_HELA_Human1.52935698
71ZNF274_21170338_ChIP-Seq_K562_Hela1.49525806
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.49203769
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46311601
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44547721
75P300_19829295_ChIP-Seq_ESCs_Human1.44172513
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43659471
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.42300262
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.41819978
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41808345
80RACK7_27058665_Chip-Seq_MCF-7_Human1.41635026
81RUNX1_26923725_Chip-Seq_HPCs_Mouse1.40032380
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38835892
83TAF15_26573619_Chip-Seq_HEK293_Human1.38554741
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38514787
85* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37563170
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35375511
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34580167
88BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34264342
89* RING1B_27294783_Chip-Seq_ESCs_Mouse1.31180584
90UTX_26944678_Chip-Seq_JUKART_Human1.30824596
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.30328444
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29934870
93SA1_27219007_Chip-Seq_ERYTHROID_Human1.29085847
94CREB1_26743006_Chip-Seq_LNCaP_Human1.28942001
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27526031
96EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27348065
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27314452
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27184647
99NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26413160
100* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25527441
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24375572
102* RING1B_27294783_Chip-Seq_NPCs_Mouse1.24278524
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23542327
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23429613
105* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22975592
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.22893351
107MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22514332
108SOX2_21211035_ChIP-Seq_LN229_Gbm1.22134794
109FUS_26573619_Chip-Seq_HEK293_Human1.21754681
110THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21207606
111* AR_25329375_ChIP-Seq_VCAP_Human1.21093599
112MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19213577
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18027376
114E2F1_21310950_ChIP-Seq_MCF-7_Human1.16120759
115STAT3_23295773_ChIP-Seq_U87_Human1.15824411
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14629283
117WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14356914
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14317987
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13683105
120IRF8_22096565_ChIP-ChIP_GC-B_Human1.12910277
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12619268
122* AR_19668381_ChIP-Seq_PC3_Human1.12505069
123CTCF_21964334_ChIP-Seq_BJAB-B_Human1.12018505
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10576218
125MYB_26560356_Chip-Seq_TH1_Human1.09820359
126BCOR_27268052_Chip-Seq_Bcells_Human1.09189292
127MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09001152
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08661351
129TP53_16413492_ChIP-PET_HCT116_Human1.08161179
130ELF1_20517297_ChIP-Seq_JURKAT_Human1.08155484
131ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07700595
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07607984
133BCL6_27268052_Chip-Seq_Bcells_Human1.07390587
134CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06453891
135ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05880741
136RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05557849
137* CTCF_27219007_Chip-Seq_Bcells_Human1.05498799
138ARNT_22903824_ChIP-Seq_MCF-7_Human1.04229495
139TP53_18474530_ChIP-ChIP_U2OS_Human1.03856472
140AHR_22903824_ChIP-Seq_MCF-7_Human1.03157406
141PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03114049
142KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03053955
143VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02873509
144NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02837421
145DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02396442
146STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02277499
147* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02013250
148SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01873407
149JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.01836039
150TCF4_23295773_ChIP-Seq_U87_Human1.01530501
151ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01098570
152CTCF_26484167_Chip-Seq_Bcells_Mouse1.01066023
153OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00298121
154YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00181259
155RNF2_27304074_Chip-Seq_NSC_Mouse1.00033594
156KDM5A_27292631_Chip-Seq_BREAST_Human0.99223194
157MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99077268
158SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98912898
159RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98772059
160CTCF_21964334_Chip-Seq_Bcells_Human0.98763206
161STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98543610
162CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98272730
163PRDM14_20953172_ChIP-Seq_ESCs_Human0.97803807
164SMC4_20622854_ChIP-Seq_HELA_Human0.97429244
165CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97338750
166BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97177690
167TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96915635
168TP53_20018659_ChIP-ChIP_R1E_Mouse0.96739427
169FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96651367
170CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96076994
171SMAD_19615063_ChIP-ChIP_OVARY_Human0.95393380
172* KDM2B_26808549_Chip-Seq_K562_Human0.94885842
173TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94487110
174STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94360044
175P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94191153
176SMAD3_21741376_ChIP-Seq_HESCs_Human0.93715043
177POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92993325
178TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92993325
179RUNX2_22187159_ChIP-Seq_PCA_Human0.92433074
180JUN_21703547_ChIP-Seq_K562_Human0.92300851
181POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91848127
182UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91584578
183RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90086698
184* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89488803
185SMAD3_21741376_ChIP-Seq_ESCs_Human0.89484156
186* SMAD4_21741376_ChIP-Seq_HESCs_Human0.88722044
187ESR1_20079471_ChIP-ChIP_T-47D_Human0.87525712
188BCAT_22108803_ChIP-Seq_LS180_Human0.86238685
189AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85793624
190CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85365058
191SMAD4_21741376_ChIP-Seq_EPCs_Human0.85066522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.35489063
2MP0003880_abnormal_central_pattern4.72873718
3MP0002396_abnormal_hematopoietic_system4.38364442
4MP0002822_catalepsy4.36706396
5MP0003635_abnormal_synaptic_transmissio4.17476426
6MP0002234_abnormal_pharynx_morphology3.68654912
7* MP0009745_abnormal_behavioral_response3.66593318
8MP0002063_abnormal_learning/memory/cond3.55164088
9MP0004270_analgesia3.37479209
10MP0002064_seizures3.15294396
11MP0001968_abnormal_touch/_nociception3.09744260
12MP0004782_abnormal_surfactant_physiolog2.87887142
13MP0002572_abnormal_emotion/affect_behav2.87227392
14MP0002009_preneoplasia2.79521936
15MP0002249_abnormal_larynx_morphology2.71626286
16MP0010094_abnormal_chromosome_stability2.70284801
17MP0009046_muscle_twitch2.65519127
18MP0001486_abnormal_startle_reflex2.60187105
19MP0003656_abnormal_erythrocyte_physiolo2.58291723
20MP0001501_abnormal_sleep_pattern2.57628593
21MP0002272_abnormal_nervous_system2.52001221
22MP0005671_abnormal_response_to2.50403074
23MP0002736_abnormal_nociception_after2.41246493
24MP0001348_abnormal_lacrimal_gland2.36930567
25MP0004808_abnormal_hematopoietic_stem2.32971576
26MP0001188_hyperpigmentation2.31381374
27MP0001529_abnormal_vocalization2.30302285
28MP0001440_abnormal_grooming_behavior2.29618131
29MP0003763_abnormal_thymus_physiology2.27338090
30MP0002734_abnormal_mechanical_nocicepti2.25771076
31MP0003111_abnormal_nucleus_morphology2.17884616
32MP0009780_abnormal_chondrocyte_physiolo2.16489658
33MP0002163_abnormal_gland_morphology2.16277632
34MP0008057_abnormal_DNA_replication2.15769226
35MP0002735_abnormal_chemical_nociception2.15107048
36MP0004957_abnormal_blastocyst_morpholog2.09813286
37MP0005423_abnormal_somatic_nervous2.08538567
38MP0000685_abnormal_immune_system1.96421146
39MP0003077_abnormal_cell_cycle1.92420863
40MP0000490_abnormal_crypts_of1.92338574
41MP0002067_abnormal_sensory_capabilities1.85713572
42MP0002557_abnormal_social/conspecific_i1.85365516
43MP0001800_abnormal_humoral_immune1.85074795
44MP0000778_abnormal_nervous_system1.83892775
45MP0005387_immune_system_phenotype1.83255246
46MP0001790_abnormal_immune_system1.83255246
47MP0002733_abnormal_thermal_nociception1.82718051
48MP0004924_abnormal_behavior1.78104089
49MP0005386_behavior/neurological_phenoty1.78104089
50MP0008569_lethality_at_weaning1.76751735
51MP0000703_abnormal_thymus_morphology1.76560814
52MP0001970_abnormal_pain_threshold1.76301571
53MP0003329_amyloid_beta_deposits1.71133733
54MP0002166_altered_tumor_susceptibility1.69500171
55MP0001873_stomach_inflammation1.68977832
56MP0001905_abnormal_dopamine_level1.67448364
57MP0002184_abnormal_innervation1.64752964
58MP0000049_abnormal_middle_ear1.60430306
59MP0009278_abnormal_bone_marrow1.55103567
60MP0003303_peritoneal_inflammation1.54073027
61MP0000613_abnormal_salivary_gland1.50827881
62MP0003879_abnormal_hair_cell1.47452009
63MP0003283_abnormal_digestive_organ1.46228719
64MP0009333_abnormal_splenocyte_physiolog1.45163408
65MP0004811_abnormal_neuron_physiology1.44593026
66MP0002398_abnormal_bone_marrow1.44548439
67MP0004142_abnormal_muscle_tone1.41862330
68MP0004858_abnormal_nervous_system1.41391881
69MP0000955_abnormal_spinal_cord1.40961453
70MP0005000_abnormal_immune_tolerance1.37262530
71MP0006276_abnormal_autonomic_nervous1.36672304
72MP0002909_abnormal_adrenal_gland1.34315333
73MP0002882_abnormal_neuron_morphology1.30372301
74* MP0002066_abnormal_motor_capabilities/c1.29949688
75MP0003453_abnormal_keratinocyte_physiol1.29657869
76MP0002405_respiratory_system_inflammati1.29344546
77MP0005646_abnormal_pituitary_gland1.28696039
78MP0004885_abnormal_endolymph1.28434428
79MP0008932_abnormal_embryonic_tissue1.27112221
80MP0001984_abnormal_olfaction1.24341889
81MP0005409_darkened_coat_color1.21233414
82MP0001502_abnormal_circadian_rhythm1.19981123
83MP0000350_abnormal_cell_proliferation1.18845654
84MP0001835_abnormal_antigen_presentation1.17331611
85MP0003633_abnormal_nervous_system1.16449144
86MP0003693_abnormal_embryo_hatching1.16382499
87MP0002006_tumorigenesis1.15081914
88MP0005076_abnormal_cell_differentiation1.13886489
89MP0005645_abnormal_hypothalamus_physiol1.13172937
90MP0000716_abnormal_immune_system1.12793888
91MP0002420_abnormal_adaptive_immunity1.10782922
92MP0001819_abnormal_immune_cell1.10756922
93MP0002723_abnormal_immune_serum1.10405669
94MP0008872_abnormal_physiological_respon1.10091728
95MP0002722_abnormal_immune_system1.09525235
96MP0005310_abnormal_salivary_gland1.09376533
97MP0002876_abnormal_thyroid_physiology1.08901911
98MP0002254_reproductive_system_inflammat1.08787222
99MP0009379_abnormal_foot_pigmentation1.06802059
100MP0000689_abnormal_spleen_morphology1.06039263
101MP0001730_embryonic_growth_arrest1.05761309
102MP0003787_abnormal_imprinting1.02588020
103MP0003631_nervous_system_phenotype1.01907779
104MP0002452_abnormal_antigen_presenting1.01410881
105MP0002152_abnormal_brain_morphology0.99299528
106* MP0002069_abnormal_eating/drinking_beha0.98527836
107MP0005379_endocrine/exocrine_gland_phen0.98466388
108MP0000681_abnormal_thyroid_gland0.98222499
109MP0003436_decreased_susceptibility_to0.97977410
110MP0002429_abnormal_blood_cell0.97742433
111MP0004742_abnormal_vestibular_system0.97067221
112MP0008058_abnormal_DNA_repair0.96388480
113MP0003868_abnormal_feces_composition0.95744229
114MP0008007_abnormal_cellular_replicative0.94217417
115MP0000534_abnormal_ureter_morphology0.92185390
116MP0005666_abnormal_adipose_tissue0.91793955
117MP0003828_pulmonary_edema0.90872171
118MP0008874_decreased_physiological_sensi0.89806994
119MP0003183_abnormal_peptide_metabolism0.89662475
120MP0002638_abnormal_pupillary_reflex0.88942622
121MP0005499_abnormal_olfactory_system0.88848777
122MP0005394_taste/olfaction_phenotype0.88848777
123MP0004085_abnormal_heartbeat0.88702410
124MP0003866_abnormal_defecation0.85437110
125MP0002837_dystrophic_cardiac_calcinosis0.84707477
126MP0003075_altered_response_to0.84242164
127MP0003122_maternal_imprinting0.84211562
128MP0003786_premature_aging0.83262235
129MP0000313_abnormal_cell_death0.81607366
130MP0004484_altered_response_of0.80526247
131MP0005623_abnormal_meninges_morphology0.78780348
132MP0000013_abnormal_adipose_tissue0.78250658
133MP0000477_abnormal_intestine_morphology0.78181905
134MP0005171_absent_coat_pigmentation0.77154756
135MP0003632_abnormal_nervous_system0.76144482
136MP0000751_myopathy0.75841926
137MP0001177_atelectasis0.75771507
138MP0003300_gastrointestinal_ulcer0.74386219
139MP0005166_decreased_susceptibility_to0.74364466
140MP0002229_neurodegeneration0.73765524
141MP0001963_abnormal_hearing_physiology0.73557711
142MP0002019_abnormal_tumor_incidence0.73032050
143MP0005187_abnormal_penis_morphology0.71834048
144MP0001664_abnormal_digestion0.71454138
145MP0003938_abnormal_ear_development0.71302700
146MP0001919_abnormal_reproductive_system0.70986752
147MP0003690_abnormal_glial_cell0.70042505
148MP0003137_abnormal_impulse_conducting0.68791010
149MP0002102_abnormal_ear_morphology0.68558730
150MP0001943_abnormal_respiration0.68521755
151MP0005025_abnormal_response_to0.66974865
152MP0005248_abnormal_Harderian_gland0.66383129
153MP0002752_abnormal_somatic_nervous0.66319829
154MP0005380_embryogenesis_phenotype0.66010184
155MP0001672_abnormal_embryogenesis/_devel0.66010184
156MP0003634_abnormal_glial_cell0.65657229
157MP0005167_abnormal_blood-brain_barrier0.65095022
158MP0009250_abnormal_appendicular_skeleto0.63931247
159MP0003935_abnormal_craniofacial_develop0.63780940
160MP0003115_abnormal_respiratory_system0.63598711
161MP0006292_abnormal_olfactory_placode0.63419774
162MP0005375_adipose_tissue_phenotype0.63175642
163MP0005535_abnormal_body_temperature0.62517745
164MP0001485_abnormal_pinna_reflex0.62106583
165MP0001346_abnormal_lacrimal_gland0.61432394
166MP0004233_abnormal_muscle_weight0.61312470
167MP0010234_abnormal_vibrissa_follicle0.61248549
168MP0004947_skin_inflammation0.60784246
169MP0000604_amyloidosis0.60782001
170MP0005551_abnormal_eye_electrophysiolog0.60252673
171MP0000631_abnormal_neuroendocrine_gland0.59635252
172MP0000920_abnormal_myelination0.58895547
173MP0001845_abnormal_inflammatory_respons0.57814169
174MP0002090_abnormal_vision0.57640656
175MP0000678_abnormal_parathyroid_gland0.57598635
176MP0000003_abnormal_adipose_tissue0.55665522
177MP0004510_myositis0.55634544
178MP0010386_abnormal_urinary_bladder0.54874123
179MP0003861_abnormal_nervous_system0.52068290
180MP0000026_abnormal_inner_ear0.51909656
181MP0004145_abnormal_muscle_electrophysio0.51725995

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.22415039
2Myokymia (HP:0002411)7.31441782
3Short 1st metacarpal (HP:0010034)6.40329463
4Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)6.40329463
5Abnormality of the intrinsic pathway (HP:0010989)6.15068475
6Focal seizures (HP:0007359)5.74800543
7Abnormality of the 1st metacarpal (HP:0010009)5.72643418
8Abnormality of the renal collecting system (HP:0004742)5.53758396
9Visual hallucinations (HP:0002367)4.77387966
10Epileptic encephalopathy (HP:0200134)4.61687705
11Short phalanx of the thumb (HP:0009660)4.41817151
12Abnormality of the common coagulation pathway (HP:0010990)4.37037808
13Annular pancreas (HP:0001734)4.28071815
14Broad-based gait (HP:0002136)4.25429315
15Menorrhagia (HP:0000132)4.13684209
16Hyperventilation (HP:0002883)3.90832808
17Lip pit (HP:0100267)3.90771045
18Abnormality of cochlea (HP:0000375)3.85959811
19Progressive cerebellar ataxia (HP:0002073)3.76447562
20Atonic seizures (HP:0010819)3.76397413
21Febrile seizures (HP:0002373)3.72275265
22Anxiety (HP:0000739)3.65179055
23Action tremor (HP:0002345)3.63693448
24Ureteral stenosis (HP:0000071)3.62459614
25Dialeptic seizures (HP:0011146)3.61178227
26Absence seizures (HP:0002121)3.51673808
27Dysmetria (HP:0001310)3.45038529
28Generalized tonic-clonic seizures (HP:0002069)3.43933733
29Dysdiadochokinesis (HP:0002075)3.43703578
30Turricephaly (HP:0000262)3.43006999
31Fused cervical vertebrae (HP:0002949)3.42978243
32Supranuclear gaze palsy (HP:0000605)3.41548340
33Cerebral inclusion bodies (HP:0100314)3.40062174
34Ketosis (HP:0001946)3.38990080
35Depression (HP:0000716)3.38167303
36Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.33284066
37Ureteral obstruction (HP:0006000)3.24093564
38Stenosis of the external auditory canal (HP:0000402)3.19993664
39Vertebral hypoplasia (HP:0008417)3.16998342
40Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.16998342
41Neurofibrillary tangles (HP:0002185)3.16195697
42Gastrointestinal stroma tumor (HP:0100723)3.12951427
43Poor eye contact (HP:0000817)3.07753433
44Abnormal eating behavior (HP:0100738)3.05618097
45Amblyopia (HP:0000646)3.05251005
46Absent rod-and cone-mediated responses on ERG (HP:0007688)3.01272880
47Stereotypic behavior (HP:0000733)3.00820129
48Morphological abnormality of the inner ear (HP:0011390)2.99496860
49Torticollis (HP:0000473)2.95787274
50Duplicated collecting system (HP:0000081)2.95737459
51Gaze-evoked nystagmus (HP:0000640)2.92657946
52Increased hepatocellular lipid droplets (HP:0006565)2.90148573
53Vertebral arch anomaly (HP:0008438)2.88859985
54Focal dystonia (HP:0004373)2.87316302
55Excessive salivation (HP:0003781)2.85654352
56Drooling (HP:0002307)2.85654352
57Abnormal social behavior (HP:0012433)2.77741856
58Impaired social interactions (HP:0000735)2.77741856
59Postural instability (HP:0002172)2.72065417
60Mutism (HP:0002300)2.70607380
61Impaired vibration sensation in the lower limbs (HP:0002166)2.69522733
62Ankle clonus (HP:0011448)2.62261134
63Craniofacial dystonia (HP:0012179)2.61082692
64Hydroureter (HP:0000072)2.57900283
65Absent speech (HP:0001344)2.57341720
66Hemiparesis (HP:0001269)2.56302825
67Megalencephaly (HP:0001355)2.54970294
68Lipid accumulation in hepatocytes (HP:0006561)2.53800889
69Bradykinesia (HP:0002067)2.50076476
70Gastrointestinal infarctions (HP:0005244)2.49321575
71Acute lymphatic leukemia (HP:0006721)2.47080892
72Abnormality of the lower motor neuron (HP:0002366)2.46731759
73Truncal ataxia (HP:0002078)2.42859146
74Papilledema (HP:0001085)2.42166274
75Urinary bladder sphincter dysfunction (HP:0002839)2.40578257
76Morphological abnormality of the middle ear (HP:0008609)2.39206704
77Abnormality of the fingertips (HP:0001211)2.34585117
78Seborrheic dermatitis (HP:0001051)2.34534568
79Epileptiform EEG discharges (HP:0011182)2.34052093
80IgA deficiency (HP:0002720)2.33693599
81Delusions (HP:0000746)2.29899976
82Lower limb asymmetry (HP:0100559)2.29604194
83Flat acetabular roof (HP:0003180)2.28120813
84Mediastinal lymphadenopathy (HP:0100721)2.27751600
85Hypoplasia of the thymus (HP:0000778)2.27154898
86Abnormality of binocular vision (HP:0011514)2.26907956
87Diplopia (HP:0000651)2.26907956
88Genetic anticipation (HP:0003743)2.26711530
89Intention tremor (HP:0002080)2.25361283
90Fair hair (HP:0002286)2.24881153
91Ankyloglossia (HP:0010296)2.24356525
92Spinal rigidity (HP:0003306)2.23502262
93Squamous cell carcinoma (HP:0002860)2.22981677
94Intestinal fistula (HP:0100819)2.22423215
95Meningitis (HP:0001287)2.21558986
96Nasolacrimal duct obstruction (HP:0000579)2.21078041
97Incomplete penetrance (HP:0003829)2.20503585
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.19834922
99Impaired smooth pursuit (HP:0007772)2.19816683
100Fetal akinesia sequence (HP:0001989)2.19440840
101Blue irides (HP:0000635)2.19404585
102Hyperthyroidism (HP:0000836)2.19052541
103Ventricular fibrillation (HP:0001663)2.19019745
104Abnormality of chromosome segregation (HP:0002916)2.17917715
105Preauricular skin tag (HP:0000384)2.17758765
106EEG with generalized epileptiform discharges (HP:0011198)2.17184466
107Congenital hip dislocation (HP:0001374)2.16978181
108Microretrognathia (HP:0000308)2.16521633
109Scanning speech (HP:0002168)2.15710982
110Progressive inability to walk (HP:0002505)2.15704910
111Panhypogammaglobulinemia (HP:0003139)2.14891454
112Agammaglobulinemia (HP:0004432)2.14067205
113Urinary urgency (HP:0000012)2.13847488
114Pointed chin (HP:0000307)2.13530634
115Abnormality of the phalanges of the hallux (HP:0010057)2.13300864
116Short thumb (HP:0009778)2.11629287
117Retinal dysplasia (HP:0007973)2.10618458
118Long foot (HP:0001833)2.09776621
119Short hallux (HP:0010109)2.09721163
120Bowel incontinence (HP:0002607)2.09138220
121Abnormality of cells of the lymphoid lineage (HP:0012140)2.09045503
122Recurrent viral infections (HP:0004429)2.08719288
123Lower limb amyotrophy (HP:0007210)2.08689668
124Limb dystonia (HP:0002451)2.07447640
125Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.07312360
126Inappropriate behavior (HP:0000719)2.06112448
127Psychosis (HP:0000709)2.06030353
12811 pairs of ribs (HP:0000878)2.05886511
129Dysmetric saccades (HP:0000641)2.04942604
130Hypsarrhythmia (HP:0002521)2.04513791
131Abnormality of the prostate (HP:0008775)2.04440387
132Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04302119
133Emphysema (HP:0002097)2.03526170
134Protruding tongue (HP:0010808)2.03375764
135Cerebral edema (HP:0002181)2.02635927
136Increased circulating renin level (HP:0000848)2.02577254
137Spastic gait (HP:0002064)2.02121611
138Abnormal number of incisors (HP:0011064)2.01526494
139Abnormality of homocysteine metabolism (HP:0010919)2.00886238
140Homocystinuria (HP:0002156)2.00886238
141Absent/shortened dynein arms (HP:0200106)2.00762178
142Dynein arm defect of respiratory motile cilia (HP:0012255)2.00762178
143Abnormal EKG (HP:0003115)2.00703238
144Lymphopenia (HP:0001888)2.00425866
145Prolonged QT interval (HP:0001657)1.99897969
146Abnormality of salivation (HP:0100755)1.99329220
147Cellulitis (HP:0100658)1.98721243
148Pancreatitis (HP:0001733)1.98504722
149Long palpebral fissure (HP:0000637)1.98135017
150Obstructive sleep apnea (HP:0002870)1.97800653
151Periauricular skin pits (HP:0100277)1.96359127
152Preauricular pit (HP:0004467)1.96359127
153Cerebral hypomyelination (HP:0006808)1.94392416
154Skin tags (HP:0010609)1.94350810
155Spinal canal stenosis (HP:0003416)1.94249438
156Abnormality of the corticospinal tract (HP:0002492)1.94038971
157Generalized hypopigmentation of hair (HP:0011358)1.93990005
158Rapidly progressive (HP:0003678)1.93632930
159Aplasia involving bones of the upper limbs (HP:0009823)1.92044297
160Aplasia of the phalanges of the hand (HP:0009802)1.92044297
161Aplasia involving bones of the extremities (HP:0009825)1.92044297
162Status epilepticus (HP:0002133)1.91815409
163Anosmia (HP:0000458)1.91672845
164Increased intramyocellular lipid droplets (HP:0012240)1.91671627
165Epistaxis (HP:0000421)1.91253413
166Hypoventilation (HP:0002791)1.90627189
167Self-mutilation (HP:0000742)1.88765748
168Bronchomalacia (HP:0002780)1.88281962
169Autism (HP:0000717)1.86642309
170Inability to walk (HP:0002540)1.86590983
171Abnormal large intestine physiology (HP:0012700)1.86116755
172Aplasia/Hypoplasia of the thymus (HP:0010515)1.85932297
173Respiratory difficulties (HP:0002880)1.84458989
174Thickened helices (HP:0000391)1.83289046
175Aplasia/Hypoplasia of the hallux (HP:0008362)1.82863020
176Vasculitis (HP:0002633)1.82817211
177Abnormality of ocular smooth pursuit (HP:0000617)1.82725821
178Polyphagia (HP:0002591)1.82637421
179Increased IgE level (HP:0003212)1.82357796
180Basal cell carcinoma (HP:0002671)1.77151799
181Recurrent bronchitis (HP:0002837)1.76952048
182Abnormal ventriculo-arterial connection (HP:0011563)1.74951546
183Transposition of the great arteries (HP:0001669)1.74951546
184Abnormal connection of the cardiac segments (HP:0011545)1.74951546
185Rectal fistula (HP:0100590)1.73681536
186Rectovaginal fistula (HP:0000143)1.73681536
187Renal Fanconi syndrome (HP:0001994)1.73499804
188Limb hypertonia (HP:0002509)1.72972198
189Abnormality of male internal genitalia (HP:0000022)1.72683069
190Selective tooth agenesis (HP:0001592)1.72393169
191Increased muscle lipid content (HP:0009058)1.71765285
192Hyperacusis (HP:0010780)1.70684138
193Recurrent bacterial skin infections (HP:0005406)1.69575333
194Tetraplegia (HP:0002445)1.68410311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.97854089
2EIF2AK34.75279370
3SIK34.38413637
4NTRK33.99798049
5MAP3K93.33102864
6SMG13.16889026
7MINK13.05516911
8TNIK2.90861650
9SIK22.78062245
10BUB12.72816211
11KSR12.66064597
12MAP3K42.50414038
13DAPK22.50241934
14RIPK42.49591209
15MARK12.21978228
16MAP2K72.13363129
17CASK2.11642122
18PAK62.07930939
19BCKDK13.0812169
20CDK121.88712956
21MAP3K101.88336583
22MAP3K131.83007109
23EEF2K1.80794130
24MAP4K11.80220950
25KSR21.78899661
26PNCK1.71694195
27BCR1.67925809
28NTRK21.64375792
29TRIB31.61930214
30PLK21.55635595
31MAP2K41.54790319
32PRKD31.51956926
33CDK51.47957632
34EIF2AK21.45929634
35MAP3K121.42828738
36CAMKK11.42283931
37PTK2B1.39671286
38FES1.35410545
39NTRK11.32103970
40ICK1.28937649
41ARAF1.26470543
42GRK51.24923886
43LATS21.15880844
44DAPK11.15161861
45MAP3K21.14348871
46PRKCG1.09846082
47VRK21.06873567
48CAMK2A1.04137279
49UHMK11.03111290
50TAOK11.02488946
51BMPR21.01309720
52MAPK131.01238538
53FGR1.01127196
54CDK180.99639849
55NME20.94801677
56TAF10.93078291
57STK380.90367430
58CDK40.89110969
59CAMK10.86523398
60CAMK2B0.86217111
61TYRO30.86030432
62FER0.84805987
63CDK150.79509958
64SGK4940.79279831
65SGK2230.79279831
66CDK140.77174592
67CDK80.76088713
68CAMKK20.75656089
69STK110.74880803
70MARK20.74857529
71CDC70.73543525
72PASK0.73324340
73MAP3K140.72881312
74CDK190.72586749
75PRPF4B0.72446560
76DYRK1A0.71797505
77CDK11A0.71280703
78PAK30.70296372
79ATR0.69093870
80NEK60.68801067
81AURKA0.67218765
82FGFR40.64950126
83SGK20.63146516
84RET0.61868084
85IKBKE0.61176037
86SGK10.60123761
87PHKG10.59277162
88PHKG20.59277162
89AKT20.58263946
90OXSR10.57966483
91PDPK10.57644717
92MAP3K60.57093364
93TNK20.55321002
94LMTK20.54052581
95CSNK1G20.53813288
96CHUK0.53031973
97NME10.52809773
98PDK10.51402970
99SIK10.51209258
100TAOK20.46933051
101PRKCE0.46788160
102PIM10.46703602
103BRAF0.45951222
104PRKCH0.44741027
105RPS6KA40.44692752
106CDK90.44555424
107MAP2K10.43588528
108PINK10.43268447
109CAMK2D0.42178235
110RAF10.41872297
111CAMK1G0.41782133
112IRAK30.41731374
113CAMK2G0.41552438
114PRKCZ0.41414653
115MAPK110.40479980
116RPS6KA30.40465216
117VRK10.40340650
118FYN0.38979600
119CAMK1D0.38944926
120CHEK20.38158996
121CDK20.38140658
122CAMK40.37805257
123PIM20.37621862
124SYK0.36800668
125STK390.36535934
126PTK20.35979331
127PRKCB0.34849456
128IRAK40.34793129
129TBK10.34298728
130SGK30.34266249
131CSNK1A10.33442802
132MAPKAPK20.33213818
133STK40.32789028
134MOS0.32014548
135BRD40.31982767
136CDK70.31982328
137BMX0.31935955
138IKBKB0.31598395
139CDC42BPA0.31192605
140CSNK1E0.30950237
141IRAK20.30581389
142CHEK10.30066892
143MAP3K10.29281432
144PRKD20.28988037
145MAPK100.28512646
146ALK0.28505326
147ROCK20.28447619
148DAPK30.27678939
149MAPK120.26941432
150MAP3K80.26674065
151KDR0.26600946
152PRKACA0.26426516
153TESK20.25203301
154JAK10.24923921
155BLK0.24904048
156PRKDC0.24842073
157HIPK20.24761398
158CSNK1A1L0.23692368
159MAPKAPK50.22908221
160SCYL20.22667858
161ABL10.22437250
162PRKG20.22159856
163BTK0.21458012
164GRK60.21251974
165MAP2K60.19999828
166MELK0.19955428
167MTOR0.18641359
168RPS6KC10.17108273

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041226.94834016
2Nicotine addiction_Homo sapiens_hsa050334.00242823
3Long-term potentiation_Homo sapiens_hsa047202.98150305
4Synaptic vesicle cycle_Homo sapiens_hsa047212.93958815
5Amphetamine addiction_Homo sapiens_hsa050312.93104486
6Circadian entrainment_Homo sapiens_hsa047132.91015826
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.86102146
8Morphine addiction_Homo sapiens_hsa050322.81618638
9GABAergic synapse_Homo sapiens_hsa047272.80054315
10Olfactory transduction_Homo sapiens_hsa047402.79717395
11Glutamatergic synapse_Homo sapiens_hsa047242.71187361
12Primary immunodeficiency_Homo sapiens_hsa053402.42774308
13Dopaminergic synapse_Homo sapiens_hsa047282.36751622
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.28059065
15B cell receptor signaling pathway_Homo sapiens_hsa046622.26118177
16Allograft rejection_Homo sapiens_hsa053302.23572777
17Salivary secretion_Homo sapiens_hsa049702.19340053
18Autoimmune thyroid disease_Homo sapiens_hsa053202.04508022
19Cocaine addiction_Homo sapiens_hsa050302.00971611
20Cholinergic synapse_Homo sapiens_hsa047251.99144804
21Long-term depression_Homo sapiens_hsa047301.98945293
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94198126
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94033810
24Base excision repair_Homo sapiens_hsa034101.88993978
25Graft-versus-host disease_Homo sapiens_hsa053321.81807356
26Insulin secretion_Homo sapiens_hsa049111.81628042
27* Serotonergic synapse_Homo sapiens_hsa047261.78843325
28Renin secretion_Homo sapiens_hsa049241.78428873
29Gastric acid secretion_Homo sapiens_hsa049711.76343658
30Taste transduction_Homo sapiens_hsa047421.70036317
31* Calcium signaling pathway_Homo sapiens_hsa040201.69824341
32Oxytocin signaling pathway_Homo sapiens_hsa049211.67609166
33DNA replication_Homo sapiens_hsa030301.65589825
34Cell cycle_Homo sapiens_hsa041101.56417879
35Propanoate metabolism_Homo sapiens_hsa006401.54289855
36Asthma_Homo sapiens_hsa053101.52910956
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50143726
38Systemic lupus erythematosus_Homo sapiens_hsa053221.49565515
39Viral myocarditis_Homo sapiens_hsa054161.47122323
40Collecting duct acid secretion_Homo sapiens_hsa049661.45181157
41Gap junction_Homo sapiens_hsa045401.44707082
42GnRH signaling pathway_Homo sapiens_hsa049121.43587903
43Spliceosome_Homo sapiens_hsa030401.42686322
44Axon guidance_Homo sapiens_hsa043601.37671556
45N-Glycan biosynthesis_Homo sapiens_hsa005101.37159729
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33954165
47HTLV-I infection_Homo sapiens_hsa051661.30527821
48* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29060517
49Herpes simplex infection_Homo sapiens_hsa051681.28884712
50Melanogenesis_Homo sapiens_hsa049161.28347129
51* cAMP signaling pathway_Homo sapiens_hsa040241.28049419
52T cell receptor signaling pathway_Homo sapiens_hsa046601.27801052
53Thyroid cancer_Homo sapiens_hsa052161.24920240
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23150361
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22289863
56Leishmaniasis_Homo sapiens_hsa051401.21171872
57Estrogen signaling pathway_Homo sapiens_hsa049151.12099799
58Pancreatic cancer_Homo sapiens_hsa052121.10724974
59Influenza A_Homo sapiens_hsa051641.09852297
60Epstein-Barr virus infection_Homo sapiens_hsa051691.08046950
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07291821
62Glioma_Homo sapiens_hsa052141.07131593
63Oocyte meiosis_Homo sapiens_hsa041141.04410311
64NF-kappa B signaling pathway_Homo sapiens_hsa040641.03382886
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03276822
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02066960
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99277142
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99134030
69Antigen processing and presentation_Homo sapiens_hsa046120.97614974
70Phototransduction_Homo sapiens_hsa047440.96858972
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.94485742
72ErbB signaling pathway_Homo sapiens_hsa040120.92553673
73Type II diabetes mellitus_Homo sapiens_hsa049300.91075994
74Cardiac muscle contraction_Homo sapiens_hsa042600.90587716
75Hepatitis B_Homo sapiens_hsa051610.90065371
76Chronic myeloid leukemia_Homo sapiens_hsa052200.88743485
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88242501
78Measles_Homo sapiens_hsa051620.88023402
79Vibrio cholerae infection_Homo sapiens_hsa051100.87629471
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85275948
81Viral carcinogenesis_Homo sapiens_hsa052030.85250259
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85190755
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84570748
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83879136
85Dorso-ventral axis formation_Homo sapiens_hsa043200.82025066
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80315991
87Choline metabolism in cancer_Homo sapiens_hsa052310.79003206
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78941876
89Colorectal cancer_Homo sapiens_hsa052100.77856664
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.75338177
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75249831
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75117926
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74782687
94Toxoplasmosis_Homo sapiens_hsa051450.74274605
95mRNA surveillance pathway_Homo sapiens_hsa030150.72768876
96VEGF signaling pathway_Homo sapiens_hsa043700.72736037
97Folate biosynthesis_Homo sapiens_hsa007900.72705146
98Thyroid hormone synthesis_Homo sapiens_hsa049180.71599811
99Acute myeloid leukemia_Homo sapiens_hsa052210.70628614
100Nitrogen metabolism_Homo sapiens_hsa009100.70515618
101One carbon pool by folate_Homo sapiens_hsa006700.70458527
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68431133
103Pancreatic secretion_Homo sapiens_hsa049720.68081937
104Glucagon signaling pathway_Homo sapiens_hsa049220.67917787
105Apoptosis_Homo sapiens_hsa042100.67405044
106Alzheimers disease_Homo sapiens_hsa050100.67180788
107Osteoclast differentiation_Homo sapiens_hsa043800.67093401
108Tuberculosis_Homo sapiens_hsa051520.64205708
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63594496
110Starch and sucrose metabolism_Homo sapiens_hsa005000.63417670
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63206228
112Basal cell carcinoma_Homo sapiens_hsa052170.61608681
113Alcoholism_Homo sapiens_hsa050340.61333379
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61031426
115Renin-angiotensin system_Homo sapiens_hsa046140.60082773
116Circadian rhythm_Homo sapiens_hsa047100.58551417
117MAPK signaling pathway_Homo sapiens_hsa040100.58528233
118Dilated cardiomyopathy_Homo sapiens_hsa054140.58446688
119Rap1 signaling pathway_Homo sapiens_hsa040150.58200784
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.56942686
121Wnt signaling pathway_Homo sapiens_hsa043100.54927815
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53779075
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53245623
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52404917
125Oxidative phosphorylation_Homo sapiens_hsa001900.51920716
126Endometrial cancer_Homo sapiens_hsa052130.51863012
127Ras signaling pathway_Homo sapiens_hsa040140.51438279
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50094746
129Bladder cancer_Homo sapiens_hsa052190.50078544
130African trypanosomiasis_Homo sapiens_hsa051430.49943200
131Fructose and mannose metabolism_Homo sapiens_hsa000510.49274243
132Ribosome_Homo sapiens_hsa030100.48371404
133Mismatch repair_Homo sapiens_hsa034300.47786350
134RNA transport_Homo sapiens_hsa030130.47429618
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.47318167
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47230635
137Non-small cell lung cancer_Homo sapiens_hsa052230.45919076
138Notch signaling pathway_Homo sapiens_hsa043300.45865225
139Pentose phosphate pathway_Homo sapiens_hsa000300.45493388
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44538440
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.43800538
142Nucleotide excision repair_Homo sapiens_hsa034200.42826740
143Prostate cancer_Homo sapiens_hsa052150.42775266
144Hepatitis C_Homo sapiens_hsa051600.42623268
145Endocytosis_Homo sapiens_hsa041440.41116352
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40091100
147Bile secretion_Homo sapiens_hsa049760.39377993
148Biosynthesis of amino acids_Homo sapiens_hsa012300.39062416
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36954736
150Parkinsons disease_Homo sapiens_hsa050120.36322218
151Ovarian steroidogenesis_Homo sapiens_hsa049130.36017730
152Type I diabetes mellitus_Homo sapiens_hsa049400.34886553
153Renal cell carcinoma_Homo sapiens_hsa052110.32329598
154Prion diseases_Homo sapiens_hsa050200.32288018
155Inositol phosphate metabolism_Homo sapiens_hsa005620.31600906
156Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30412255
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29497998
158Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29144452
159Butanoate metabolism_Homo sapiens_hsa006500.27709813
160Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27569133
161Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26867014
162Hedgehog signaling pathway_Homo sapiens_hsa043400.26767434
163Chemokine signaling pathway_Homo sapiens_hsa040620.26388653
164Insulin signaling pathway_Homo sapiens_hsa049100.25553724
165mTOR signaling pathway_Homo sapiens_hsa041500.23359523
166Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21644724
167Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19119536
168Huntingtons disease_Homo sapiens_hsa050160.17475513
169Hippo signaling pathway_Homo sapiens_hsa043900.16990847

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