HTR7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)6.72876508
2synaptic vesicle maturation (GO:0016188)5.56885494
3regulation of gene silencing by RNA (GO:0060966)5.53649335
4regulation of posttranscriptional gene silencing (GO:0060147)5.53649335
5regulation of gene silencing by miRNA (GO:0060964)5.53649335
6vocalization behavior (GO:0071625)5.44941610
7establishment of viral latency (GO:0019043)5.30426215
8regulation of short-term neuronal synaptic plasticity (GO:0048172)5.19893391
9heterochromatin organization (GO:0070828)5.15003391
10synaptic vesicle exocytosis (GO:0016079)5.12215776
11protein complex localization (GO:0031503)5.05120663
12IMP biosynthetic process (GO:0006188)4.98956883
13neuron cell-cell adhesion (GO:0007158)4.95698352
14ribosome assembly (GO:0042255)4.89978283
15nuclear pore complex assembly (GO:0051292)4.81424219
16hemidesmosome assembly (GO:0031581)4.73422098
17neuronal action potential propagation (GO:0019227)4.69836223
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.65791619
19IMP metabolic process (GO:0046040)4.64943167
20L-serine metabolic process (GO:0006563)4.62293968
21proline transport (GO:0015824)4.62187251
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.58686853
23cellular protein complex localization (GO:0034629)4.49747329
24regulation of glutamate receptor signaling pathway (GO:1900449)4.49261007
25protein localization to synapse (GO:0035418)4.44108234
26mitotic metaphase plate congression (GO:0007080)4.41921650
27glutamate secretion (GO:0014047)4.37945579
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.36645317
29regulation of synaptic vesicle exocytosis (GO:2000300)4.33854954
30neurotransmitter catabolic process (GO:0042135)4.33599450
31L-alpha-amino acid transmembrane transport (GO:1902475)4.26188096
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.24755660
33neurotransmitter secretion (GO:0007269)4.19583734
34nuclear pore organization (GO:0006999)4.18741782
35ionotropic glutamate receptor signaling pathway (GO:0035235)4.18557007
36locomotory exploration behavior (GO:0035641)4.17557234
37pre-miRNA processing (GO:0031054)4.16157656
38protein localization to kinetochore (GO:0034501)4.13691163
39folic acid-containing compound biosynthetic process (GO:0009396)4.01631714
40chromatin remodeling at centromere (GO:0031055)3.99185701
41neuron recognition (GO:0008038)3.98524030
42regulation of synaptic vesicle transport (GO:1902803)3.91346381
43regulation of helicase activity (GO:0051095)3.90498761
44CENP-A containing nucleosome assembly (GO:0034080)3.87530544
45DNA replication checkpoint (GO:0000076)3.86468277
46oxygen transport (GO:0015671)3.84749324
47pore complex assembly (GO:0046931)3.83217794
48gamma-aminobutyric acid transport (GO:0015812)3.83020384
49DNA strand elongation involved in DNA replication (GO:0006271)3.82010167
50positive regulation of synaptic transmission, GABAergic (GO:0032230)3.79934426
51exploration behavior (GO:0035640)3.73466072
52layer formation in cerebral cortex (GO:0021819)3.73278804
53response to X-ray (GO:0010165)3.73188052
54glutamate receptor signaling pathway (GO:0007215)3.72995093
55positive regulation of SMAD protein import into nucleus (GO:0060391)3.71032496
56regulation of cell fate specification (GO:0042659)3.64059863
57DNA strand elongation (GO:0022616)3.63018902
58regulation of T-helper 1 cell differentiation (GO:0045625)3.62004916
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.59295534
60neurotransmitter transport (GO:0006836)3.57047908
61gamma-aminobutyric acid signaling pathway (GO:0007214)3.56931114
62axonal fasciculation (GO:0007413)3.55541145
63protein localization to chromosome, centromeric region (GO:0071459)3.55442315
64purine nucleobase biosynthetic process (GO:0009113)3.54942929
65glycine transport (GO:0015816)3.53507282
66negative regulation of mitotic sister chromatid separation (GO:2000816)3.53010072
67negative regulation of sister chromatid segregation (GO:0033046)3.53010072
68negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.53010072
69negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.53010072
70negative regulation of mitotic sister chromatid segregation (GO:0033048)3.53010072
71nucleobase biosynthetic process (GO:0046112)3.51036627
72negative regulation of chromosome segregation (GO:0051985)3.48904213
73response to auditory stimulus (GO:0010996)3.46969275
74neuron-neuron synaptic transmission (GO:0007270)3.46566207
75DNA unwinding involved in DNA replication (GO:0006268)3.45906393
76regulation of neuronal synaptic plasticity (GO:0048168)3.45856934
77metaphase plate congression (GO:0051310)3.45178763
78regulation of long-term neuronal synaptic plasticity (GO:0048169)3.44434105
79regulation of neurotransmitter levels (GO:0001505)3.43149864
80regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.41818369
81DNA replication-independent nucleosome assembly (GO:0006336)3.38228513
82DNA replication-independent nucleosome organization (GO:0034724)3.38228513
83synaptic transmission, glutamatergic (GO:0035249)3.36655548
84Rap protein signal transduction (GO:0032486)3.36506386
85response to histamine (GO:0034776)3.36366162
86histone exchange (GO:0043486)3.33994179
87activation of protein kinase A activity (GO:0034199)3.31401230
88formation of translation preinitiation complex (GO:0001731)3.30256424
89regulation of vesicle fusion (GO:0031338)3.29793177
90postsynaptic membrane organization (GO:0001941)3.28937583
91mating behavior (GO:0007617)3.26331042
92regulation of dendritic cell antigen processing and presentation (GO:0002604)3.25030866
93negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.24128695
94regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.22476409
95membrane tubulation (GO:0097320)3.22238975
96mitotic spindle checkpoint (GO:0071174)3.22224631
97neuromuscular process controlling posture (GO:0050884)3.21549700
98regulation of histone H3-K9 methylation (GO:0051570)3.21142837
99mitotic sister chromatid cohesion (GO:0007064)3.20803919
100neurotransmitter-gated ion channel clustering (GO:0072578)3.20667568
101spindle checkpoint (GO:0031577)3.19314604
102regulation of chromosome segregation (GO:0051983)3.18227506
103regulation of cAMP-dependent protein kinase activity (GO:2000479)3.18179865
104cell fate commitment involved in formation of primary germ layer (GO:0060795)3.17583351
105paraxial mesoderm development (GO:0048339)3.15858774
106dendritic spine morphogenesis (GO:0060997)3.15467324
107synaptic vesicle docking involved in exocytosis (GO:0016081)3.15355139
108regulation of mitotic metaphase/anaphase transition (GO:0030071)3.12058969
109regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.12058969
110DNA replication-dependent nucleosome organization (GO:0034723)3.08083126
111DNA replication-dependent nucleosome assembly (GO:0006335)3.08083126
112regulation of synapse structural plasticity (GO:0051823)3.08059456
113telomere maintenance via semi-conservative replication (GO:0032201)3.07948856
114regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07564995
115mitotic G2/M transition checkpoint (GO:0044818)3.07100769
116synaptic vesicle endocytosis (GO:0048488)3.06392590
117mitotic spindle assembly checkpoint (GO:0007094)3.05152766
118anterior/posterior axis specification, embryo (GO:0008595)3.04903571
119transmission of nerve impulse (GO:0019226)3.03179616
120regulation of sister chromatid segregation (GO:0033045)3.02437147
121regulation of mitotic sister chromatid separation (GO:0010965)3.02437147
122regulation of mitotic sister chromatid segregation (GO:0033047)3.02437147
123regulation of translational termination (GO:0006449)3.01428692
124positive regulation of synapse assembly (GO:0051965)3.01346887
125presynaptic membrane organization (GO:0097090)3.00965352
126presynaptic membrane assembly (GO:0097105)3.00717242
127neuromuscular process controlling balance (GO:0050885)3.00698966
128negative regulation of fibroblast apoptotic process (GO:2000270)3.00521206
129double-strand break repair via nonhomologous end joining (GO:0006303)2.99706013
130non-recombinational repair (GO:0000726)2.99706013
131cerebellar Purkinje cell differentiation (GO:0021702)2.99553584
132cellular potassium ion homeostasis (GO:0030007)2.98389023
133establishment of chromosome localization (GO:0051303)2.97819583
134negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96941507
135positive regulation of chromosome segregation (GO:0051984)2.96787055
136synapse assembly (GO:0007416)2.96736242
137negative regulation of telomerase activity (GO:0051974)2.96443812
138membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.95464410
139positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.95421278
140spindle assembly checkpoint (GO:0071173)2.95190086
141long-term memory (GO:0007616)2.94799566
142regulation of postsynaptic membrane potential (GO:0060078)2.93297696
143regulation of mitotic spindle checkpoint (GO:1903504)2.92845660
144regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.92845660
145regulation of nuclear cell cycle DNA replication (GO:0033262)2.91043151
146lysine metabolic process (GO:0006553)2.90660836
147lysine catabolic process (GO:0006554)2.90660836
148suckling behavior (GO:0001967)2.89975793
149auditory behavior (GO:0031223)2.89612091
150DNA ligation (GO:0006266)2.89094338
151mitotic nuclear envelope disassembly (GO:0007077)2.88906286
152startle response (GO:0001964)2.88426174
153regulation of gene silencing (GO:0060968)2.87479684
154negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86649140
155telomere maintenance via telomerase (GO:0007004)2.86613008
156positive regulation of membrane potential (GO:0045838)2.85993597
157mitotic chromosome condensation (GO:0007076)2.85267178
158RNA-dependent DNA replication (GO:0006278)2.85154953
159gap junction assembly (GO:0016264)2.84776061
160clathrin coat assembly (GO:0048268)2.84751105
161ATP-dependent chromatin remodeling (GO:0043044)2.83758805
162cerebellar granule cell differentiation (GO:0021707)2.83739032
163membrane depolarization during action potential (GO:0086010)2.83279704
164negative regulation of gene silencing (GO:0060969)2.82594421
165regulation of protein kinase A signaling (GO:0010738)2.82082730
166negative regulation of dendrite morphogenesis (GO:0050774)2.81906865
167membrane hyperpolarization (GO:0060081)2.81630444
168membrane depolarization (GO:0051899)2.81090845
169negative regulation of mitosis (GO:0045839)2.81017313
170sodium ion export (GO:0071436)2.79706206
171regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79473467
172regulation of centriole replication (GO:0046599)2.79363699
173mitotic sister chromatid segregation (GO:0000070)2.77215781
174regulation of synaptic transmission, glutamatergic (GO:0051966)2.76867268
175regulation of synaptic transmission, GABAergic (GO:0032228)2.76563619
176negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.76129209
177negative regulation of ligase activity (GO:0051352)2.76129209
178DNA double-strand break processing (GO:0000729)2.75991835
179regulation of transcription from RNA polymerase I promoter (GO:0006356)2.75700424
180DNA duplex unwinding (GO:0032508)2.74880706
181regulation of amyloid precursor protein catabolic process (GO:1902991)2.74774181
182cell migration in hindbrain (GO:0021535)2.74625349
183neuromuscular process (GO:0050905)2.74195077
184* synaptic transmission (GO:0007268)2.72973958
185regulation of neurotransmitter secretion (GO:0046928)2.71928355
186social behavior (GO:0035176)2.71753397
187intraspecies interaction between organisms (GO:0051703)2.71753397
188histone arginine methylation (GO:0034969)2.71440990
189nuclear envelope disassembly (GO:0051081)2.70992936
190membrane disassembly (GO:0030397)2.70992936
191NIK/NF-kappaB signaling (GO:0038061)2.69778134
192innervation (GO:0060384)2.69437220
193vesicle transport along microtubule (GO:0047496)2.68448945
194cellular response to ammonium ion (GO:0071242)2.68001643
195G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.67240049
196regulation of clathrin-mediated endocytosis (GO:2000369)2.66930211
197G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.66467470
198dendrite morphogenesis (GO:0048813)2.64771897
199prepulse inhibition (GO:0060134)2.64546655
200regulation of beta-amyloid formation (GO:1902003)2.64202384

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.56391549
2EZH2_22144423_ChIP-Seq_EOC_Human5.15888032
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.19990407
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.53901880
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.40485974
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.37524680
7GBX2_23144817_ChIP-Seq_PC3_Human3.26448350
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21669422
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02123832
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.94869247
11* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91234840
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91145434
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.90758237
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87311944
15* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87247598
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81768947
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.73211316
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.73211316
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.73211316
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.67146907
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60647718
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60647718
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53624285
24AR_21909140_ChIP-Seq_LNCAP_Human2.51869003
25* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51011101
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48916757
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.47399640
28* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45464292
29* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44983355
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.44727790
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.43901292
32* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36905616
33EZH2_27304074_Chip-Seq_ESCs_Mouse2.33280714
34* REST_21632747_ChIP-Seq_MESCs_Mouse2.31724394
35NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.30732405
36MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30147071
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29648620
38IKZF1_21737484_ChIP-ChIP_HCT116_Human2.29324302
39SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23162444
40SMAD_19615063_ChIP-ChIP_OVARY_Human2.16081166
41IGF1R_20145208_ChIP-Seq_DFB_Human2.14987226
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10912507
43MYCN_18555785_ChIP-Seq_MESCs_Mouse2.09678976
44EGR1_19374776_ChIP-ChIP_THP-1_Human2.08146927
45E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07991151
46* TAF15_26573619_Chip-Seq_HEK293_Human2.06229050
47* EED_16625203_ChIP-ChIP_MESCs_Mouse2.05244721
48RNF2_27304074_Chip-Seq_ESCs_Mouse2.04686907
49DROSHA_22980978_ChIP-Seq_HELA_Human2.04012064
50TCF3_18692474_ChIP-Seq_MEFs_Mouse2.02939094
51NANOG_18555785_ChIP-Seq_MESCs_Mouse2.02340038
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00881158
53* EZH2_27294783_Chip-Seq_ESCs_Mouse1.96804225
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96578662
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.96381863
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94215508
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93292583
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.91074067
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.90425138
60NANOG_16153702_ChIP-ChIP_HESCs_Human1.84054929
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83770665
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83112915
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.82834177
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74815802
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.71474780
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.71323381
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70771983
68* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62644373
69* SMAD4_21799915_ChIP-Seq_A2780_Human1.61404984
70JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60259897
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59565277
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.58939269
73RARB_27405468_Chip-Seq_BRAIN_Mouse1.55541020
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55324446
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53798814
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53509290
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.52593324
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51793597
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49407143
80NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.49273582
81* P300_19829295_ChIP-Seq_ESCs_Human1.49030882
82DCP1A_22483619_ChIP-Seq_HELA_Human1.48447282
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47390460
84AR_21572438_ChIP-Seq_LNCaP_Human1.46645218
85TCF3_18692474_ChIP-Seq_MESCs_Mouse1.45719680
86SOX2_16153702_ChIP-ChIP_HESCs_Human1.45713286
87* ELK1_19687146_ChIP-ChIP_HELA_Human1.45341715
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45092279
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44712591
90ETS1_20019798_ChIP-Seq_JURKAT_Human1.42919022
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42899875
92* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42236416
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40934380
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39469351
95ER_23166858_ChIP-Seq_MCF-7_Human1.38726719
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36994082
97TTF2_22483619_ChIP-Seq_HELA_Human1.34989062
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.33791979
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33637591
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33187145
101AR_25329375_ChIP-Seq_VCAP_Human1.32630238
102* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32095407
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.31772098
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31678874
105VDR_22108803_ChIP-Seq_LS180_Human1.31485202
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29851062
107ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28745305
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28680557
109CLOCK_20551151_ChIP-Seq_293T_Human1.27527188
110HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23917431
111* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23770256
112* SOX2_21211035_ChIP-Seq_LN229_Gbm1.23538193
113XRN2_22483619_ChIP-Seq_HELA_Human1.23437984
114* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23364719
115* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.23054281
116AHR_22903824_ChIP-Seq_MCF-7_Human1.22959809
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22852254
118* RING1B_27294783_Chip-Seq_ESCs_Mouse1.22105700
119ERG_21242973_ChIP-ChIP_JURKAT_Human1.21019199
120NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20782641
121* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20574089
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19367190
123FOXP3_21729870_ChIP-Seq_TREG_Human1.18064531
124* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17767499
125STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17303514
126TFEB_21752829_ChIP-Seq_HELA_Human1.16011680
127CBX2_27304074_Chip-Seq_ESCs_Mouse1.15763057
128CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15737411
129ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14494082
130* STAT3_23295773_ChIP-Seq_U87_Human1.14097655
131KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13912303
132ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13766078
133* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13523677
134PRDM14_20953172_ChIP-Seq_ESCs_Human1.12644488
135PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12198804
136ZNF274_21170338_ChIP-Seq_K562_Hela1.12115997
137SOX2_18692474_ChIP-Seq_MEFs_Mouse1.11955486
138BCAT_22108803_ChIP-Seq_LS180_Human1.11428329
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10525049
140GABP_19822575_ChIP-Seq_HepG2_Human1.09854603
141PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07753528
142* ARNT_22903824_ChIP-Seq_MCF-7_Human1.07098262
143SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06515287
144* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06409495
145* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05834450
146* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05230554
147CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04951075
148SOX17_20123909_ChIP-Seq_XEN_Mouse1.04722024
149WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04502142
150DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03329002
151EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03198165
152JUN_21703547_ChIP-Seq_K562_Human1.03009338
153DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02875975
154TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02649146
155RING1B_27294783_Chip-Seq_NPCs_Mouse1.02281321
156RNF2_27304074_Chip-Seq_NSC_Mouse1.01527491
157* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01226353
158* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01169282
159AR_19668381_ChIP-Seq_PC3_Human1.01144657
160RXR_22108803_ChIP-Seq_LS180_Human1.00985350
161ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00679043
162POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00278453
163* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98752591
164P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98717803
165E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98553504
166NANOG_21062744_ChIP-ChIP_HESCs_Human0.98236076
167TCF4_23295773_ChIP-Seq_U87_Human0.98226689
168TP53_18474530_ChIP-ChIP_U2OS_Human0.97783844
169ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97525413
170NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97022584
171* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96586795
172RUNX2_22187159_ChIP-Seq_PCA_Human0.96240421
173CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95961012
174* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95889661
175SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95557669
176OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95224104
177CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94475044
178YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93054914
179TCF4_22108803_ChIP-Seq_LS180_Human0.92630931
180VDR_23849224_ChIP-Seq_CD4+_Human0.91751813
181ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91613667
182VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91126250
183* CBP_20019798_ChIP-Seq_JUKART_Human0.90571890
184* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90571890
185TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90190859
186* KDM2B_26808549_Chip-Seq_REH_Human0.90009086
187SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89753145
188SMAD3_21741376_ChIP-Seq_ESCs_Human0.89434667
189ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89423364
190* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89334411
191NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89028258
192PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88735458
193KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88676071
194POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.88399312
195* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.88338042
196NOTCH1_21737748_ChIP-Seq_TLL_Human0.87278634
197KAP1_27257070_Chip-Seq_ESCs_Mouse0.87152913
198KDM2B_26808549_Chip-Seq_K562_Human0.86918515
199TP53_16413492_ChIP-PET_HCT116_Human0.86176256
200NANOG_18555785_Chip-Seq_ESCs_Mouse0.85504157

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development5.66613601
2MP0004859_abnormal_synaptic_plasticity4.84245243
3MP0003880_abnormal_central_pattern4.53378068
4MP0002254_reproductive_system_inflammat4.49969094
5MP0000579_abnormal_nail_morphology3.97149918
6MP0004957_abnormal_blastocyst_morpholog3.82280168
7MP0003693_abnormal_embryo_hatching3.70340059
8MP0003635_abnormal_synaptic_transmissio3.55266896
9MP0009046_muscle_twitch3.54092843
10MP0003111_abnormal_nucleus_morphology3.35649884
11MP0001348_abnormal_lacrimal_gland3.25309150
12MP0001968_abnormal_touch/_nociception3.17182263
13MP0002735_abnormal_chemical_nociception2.96745322
14* MP0009745_abnormal_behavioral_response2.95926592
15MP0010094_abnormal_chromosome_stability2.93186271
16MP0004510_myositis2.90794017
17MP0004270_analgesia2.86654391
18* MP0002064_seizures2.74060728
19MP0002736_abnormal_nociception_after2.70037058
20MP0002063_abnormal_learning/memory/cond2.62887718
21MP0002876_abnormal_thyroid_physiology2.61714802
22MP0008932_abnormal_embryonic_tissue2.60554672
23MP0002734_abnormal_mechanical_nocicepti2.59587706
24MP0006276_abnormal_autonomic_nervous2.54536849
25MP0002272_abnormal_nervous_system2.48805744
26MP0005645_abnormal_hypothalamus_physiol2.42360821
27MP0003566_abnormal_cell_adhesion2.41973349
28MP0005423_abnormal_somatic_nervous2.38385403
29MP0009672_abnormal_birth_weight2.36629080
30MP0003077_abnormal_cell_cycle2.35382843
31MP0003705_abnormal_hypodermis_morpholog2.34329530
32MP0008007_abnormal_cellular_replicative2.34051883
33MP0002796_impaired_skin_barrier2.31297207
34MP0002572_abnormal_emotion/affect_behav2.31212113
35MP0003879_abnormal_hair_cell2.28738650
36MP0001501_abnormal_sleep_pattern2.26584197
37MP0008057_abnormal_DNA_replication2.22947190
38MP0008058_abnormal_DNA_repair2.21357263
39MP0001730_embryonic_growth_arrest2.18992269
40* MP0002733_abnormal_thermal_nociception2.15491435
41MP0001849_ear_inflammation2.10851977
42MP0001486_abnormal_startle_reflex2.09174441
43MP0004858_abnormal_nervous_system2.06878568
44MP0001346_abnormal_lacrimal_gland2.02758318
45MP0004272_abnormal_basement_membrane2.02685870
46* MP0001970_abnormal_pain_threshold1.97739487
47MP0003718_maternal_effect1.96217329
48MP0003890_abnormal_embryonic-extraembry1.93845583
49MP0002067_abnormal_sensory_capabilities1.84798629
50MP0000350_abnormal_cell_proliferation1.81529634
51MP0002184_abnormal_innervation1.80490764
52MP0001529_abnormal_vocalization1.79149008
53MP0003329_amyloid_beta_deposits1.77109216
54MP0010307_abnormal_tumor_latency1.75469471
55MP0008569_lethality_at_weaning1.69454929
56MP0003453_abnormal_keratinocyte_physiol1.66599564
57MP0001440_abnormal_grooming_behavior1.66560632
58MP0010234_abnormal_vibrissa_follicle1.62993993
59MP0002138_abnormal_hepatobiliary_system1.62384364
60MP0009697_abnormal_copulation1.58006173
61MP0005310_abnormal_salivary_gland1.54207973
62MP0002060_abnormal_skin_morphology1.52229126
63MP0000778_abnormal_nervous_system1.52009323
64MP0000762_abnormal_tongue_morphology1.50932421
65MP0005386_behavior/neurological_phenoty1.48355019
66MP0004924_abnormal_behavior1.48355019
67MP0004185_abnormal_adipocyte_glucose1.48042032
68MP0005501_abnormal_skin_physiology1.45157835
69MP0004142_abnormal_muscle_tone1.44974139
70MP0002557_abnormal_social/conspecific_i1.42271744
71MP0005380_embryogenesis_phenotype1.38497578
72MP0001672_abnormal_embryogenesis/_devel1.38497578
73MP0004811_abnormal_neuron_physiology1.38459867
74MP0005257_abnormal_intraocular_pressure1.38263093
75MP0001293_anophthalmia1.37445766
76MP0000537_abnormal_urethra_morphology1.35865208
77MP0002085_abnormal_embryonic_tissue1.34304155
78MP0002080_prenatal_lethality1.31905241
79* MP0002066_abnormal_motor_capabilities/c1.31123085
80MP0002697_abnormal_eye_size1.30864834
81MP0001835_abnormal_antigen_presentation1.30287905
82MP0003806_abnormal_nucleotide_metabolis1.29495232
83MP0002084_abnormal_developmental_patter1.28847599
84MP0004197_abnormal_fetal_growth/weight/1.25354343
85MP0003787_abnormal_imprinting1.24842970
86MP0000685_abnormal_immune_system1.23940145
87MP0003448_altered_tumor_morphology1.23774801
88MP0001697_abnormal_embryo_size1.22174147
89MP0001216_abnormal_epidermal_layer1.21718964
90MP0000751_myopathy1.20778899
91MP0001502_abnormal_circadian_rhythm1.20352889
92MP0000955_abnormal_spinal_cord1.18899721
93MP0009703_decreased_birth_body1.18239041
94MP0002909_abnormal_adrenal_gland1.17402684
95MP0003045_fibrosis1.16941295
96MP0008872_abnormal_physiological_respon1.15567577
97MP0003984_embryonic_growth_retardation1.14544029
98MP0002882_abnormal_neuron_morphology1.14465461
99MP0004233_abnormal_muscle_weight1.14039830
100MP0000858_altered_metastatic_potential1.12618646
101MP0002111_abnormal_tail_morphology1.12016996
102MP0000467_abnormal_esophagus_morphology1.10998038
103MP0008877_abnormal_DNA_methylation1.10993043
104MP0001905_abnormal_dopamine_level1.10631014
105MP0000604_amyloidosis1.10188662
106MP0002088_abnormal_embryonic_growth/wei1.09726595
107MP0010352_gastrointestinal_tract_polyps1.09617065
108MP0003123_paternal_imprinting1.08778009
109MP0002086_abnormal_extraembryonic_tissu1.07233284
110MP0010030_abnormal_orbit_morphology1.06913878
111MP0003937_abnormal_limbs/digits/tail_de1.05543805
112MP0003122_maternal_imprinting1.05328063
113MP0000313_abnormal_cell_death1.02797194
114MP0005623_abnormal_meninges_morphology1.02772435
115MP0009278_abnormal_bone_marrow1.01493666
116MP0000678_abnormal_parathyroid_gland1.00662825
117MP0001853_heart_inflammation1.00029334
118MP0003186_abnormal_redox_activity0.97530785
119MP0002277_abnormal_respiratory_mucosa0.97270449
120MP0003786_premature_aging0.97145485
121MP0002822_catalepsy0.95834684
122MP0003221_abnormal_cardiomyocyte_apopto0.95206660
123MP0000627_abnormal_mammary_gland0.95201416
124MP0008874_decreased_physiological_sensi0.94888666
125MP0001915_intracranial_hemorrhage0.94600396
126MP0002090_abnormal_vision0.93364000
127MP0003633_abnormal_nervous_system0.93152363
128MP0003119_abnormal_digestive_system0.92693230
129MP0005621_abnormal_cell_physiology0.92398799
130MP0005076_abnormal_cell_differentiation0.92381325
131MP0006035_abnormal_mitochondrial_morpho0.89435507
132MP0000490_abnormal_crypts_of0.88963079
133MP0004742_abnormal_vestibular_system0.88631398
134MP0001485_abnormal_pinna_reflex0.87464251
135MP0001188_hyperpigmentation0.87443664
136MP0010386_abnormal_urinary_bladder0.87395278
137MP0005384_cellular_phenotype0.87206562
138MP0002229_neurodegeneration0.86380467
139MP0000358_abnormal_cell_content/0.84505170
140MP0003075_altered_response_to0.84232266
141MP0000432_abnormal_head_morphology0.83939968
142MP0001873_stomach_inflammation0.83628130
143MP0008260_abnormal_autophagy0.82400364
144MP0001881_abnormal_mammary_gland0.80823801
145MP0010771_integument_phenotype0.80680102
146MP0003631_nervous_system_phenotype0.79328035
147MP0000428_abnormal_craniofacial_morphol0.78706544
148MP0002069_abnormal_eating/drinking_beha0.78290776
149MP0009780_abnormal_chondrocyte_physiolo0.76945267
150* MP0005535_abnormal_body_temperature0.76483352
151MP0003567_abnormal_fetal_cardiomyocyte0.76253690
152MP0005197_abnormal_uvea_morphology0.76038247
153MP0001286_abnormal_eye_development0.76000247
154MP0009053_abnormal_anal_canal0.75961236
155MP0005023_abnormal_wound_healing0.74371171
156MP0010678_abnormal_skin_adnexa0.73524327
157MP0003634_abnormal_glial_cell0.73178487
158MP0001963_abnormal_hearing_physiology0.72598834
159MP0005646_abnormal_pituitary_gland0.71785860
160MP0000920_abnormal_myelination0.70458177
161MP0004145_abnormal_muscle_electrophysio0.70209735
162MP0001790_abnormal_immune_system0.68952342
163MP0005387_immune_system_phenotype0.68952342
164MP0001984_abnormal_olfaction0.68568764
165MP0004484_altered_response_of0.67852755
166MP0000377_abnormal_hair_follicle0.67657533
167MP0003690_abnormal_glial_cell0.66914249
168MP0002152_abnormal_brain_morphology0.66514795
169MP0002233_abnormal_nose_morphology0.63604104
170MP0002092_abnormal_eye_morphology0.63296305
171MP0004264_abnormal_extraembryonic_tissu0.62957759
172MP0003315_abnormal_perineum_morphology0.61960966
173MP0003303_peritoneal_inflammation0.60455414
174MP0001191_abnormal_skin_condition0.59538097
175MP0002752_abnormal_somatic_nervous0.59246694
176MP0005395_other_phenotype0.59195474
177MP0001661_extended_life_span0.59052004
178MP0004885_abnormal_endolymph0.58378207
179MP0001943_abnormal_respiration0.57307032
180MP0003755_abnormal_palate_morphology0.57051768
181MP0002019_abnormal_tumor_incidence0.56621887
182MP0002089_abnormal_postnatal_growth/wei0.56271412
183MP0002837_dystrophic_cardiac_calcinosis0.53891135
184MP0002877_abnormal_melanocyte_morpholog0.51930447
185MP0003137_abnormal_impulse_conducting0.48481248
186MP0000470_abnormal_stomach_morphology0.46991900
187MP0000538_abnormal_urinary_bladder0.46947089
188MP0003183_abnormal_peptide_metabolism0.46181571
189MP0001177_atelectasis0.45942891
190MP0000569_abnormal_digit_pigmentation0.44746390
191MP0001299_abnormal_eye_distance/0.44730502
192MP0000026_abnormal_inner_ear0.44381316
193MP0001851_eye_inflammation0.42960780
194MP0003646_muscle_fatigue0.42552607
195MP0004215_abnormal_myocardial_fiber0.41615046

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.05771023
2Myokymia (HP:0002411)5.59117338
3Focal seizures (HP:0007359)5.28767632
4Selective tooth agenesis (HP:0001592)5.10547067
5Atonic seizures (HP:0010819)5.08465986
6Supranuclear gaze palsy (HP:0000605)4.75304816
7Spastic diplegia (HP:0001264)4.50189408
8Fragile nails (HP:0001808)4.49047132
9Visual hallucinations (HP:0002367)4.11146976
10Multiple enchondromatosis (HP:0005701)4.06756434
11Febrile seizures (HP:0002373)4.02305878
12Absence seizures (HP:0002121)3.99835580
13Abnormality of the labia minora (HP:0012880)3.98584640
14Generalized tonic-clonic seizures (HP:0002069)3.89271560
15Progressive cerebellar ataxia (HP:0002073)3.88939991
16Epileptic encephalopathy (HP:0200134)3.77285683
17Cortical dysplasia (HP:0002539)3.74333716
18Milia (HP:0001056)3.58868997
19Hypercortisolism (HP:0001578)3.54696580
20Action tremor (HP:0002345)3.52282550
21Colon cancer (HP:0003003)3.51710695
22Dialeptic seizures (HP:0011146)3.44356097
23Agnosia (HP:0010524)3.44041353
24Onycholysis (HP:0001806)3.42348184
25Progressive external ophthalmoplegia (HP:0000590)3.40448044
26Abnormality of calcium-phosphate metabolism (HP:0100530)3.24898578
27Pili torti (HP:0003777)3.23604385
28Papilledema (HP:0001085)3.16215152
29Neurofibrillary tangles (HP:0002185)3.15266005
30Fetal akinesia sequence (HP:0001989)3.12725028
31Plantar hyperkeratosis (HP:0007556)2.98096898
32Atrophic scars (HP:0001075)2.97399914
33Urinary bladder sphincter dysfunction (HP:0002839)2.95461461
34Abnormal eating behavior (HP:0100738)2.93757854
35Anxiety (HP:0000739)2.92082409
36Pterygium (HP:0001059)2.89671915
37Mutism (HP:0002300)2.86807514
38Progressive inability to walk (HP:0002505)2.85967742
39Nephroblastoma (Wilms tumor) (HP:0002667)2.85741330
40Pheochromocytoma (HP:0002666)2.84909413
41Abnormality of nail color (HP:0100643)2.78750811
42Dysmetria (HP:0001310)2.77965223
43Thick nail (HP:0001805)2.77040862
44Cerebral inclusion bodies (HP:0100314)2.75441622
45Ankle clonus (HP:0011448)2.72704628
46Birth length less than 3rd percentile (HP:0003561)2.69904510
47Abnormal lung lobation (HP:0002101)2.67227405
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.65660392
49Truncal ataxia (HP:0002078)2.65251971
50Ependymoma (HP:0002888)2.62109158
51Chronic mucocutaneous candidiasis (HP:0002728)2.62082391
52Recurrent cutaneous fungal infections (HP:0011370)2.62082391
53Embryonal renal neoplasm (HP:0011794)2.61288493
54Absent eyelashes (HP:0000561)2.60798171
55Insidious onset (HP:0003587)2.59878931
56Termporal pattern (HP:0011008)2.59878931
57Keratoconjunctivitis (HP:0001096)2.59499744
58Abnormality of the salivary glands (HP:0010286)2.59437567
59Choanal stenosis (HP:0000452)2.59011796
60Depression (HP:0000716)2.58266954
61Progressive muscle weakness (HP:0003323)2.57810959
62Dysdiadochokinesis (HP:0002075)2.51654471
63Megalencephaly (HP:0001355)2.50619720
64Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.50442868
65Polyphagia (HP:0002591)2.49551367
66Symptomatic seizures (HP:0011145)2.48913456
67Broad-based gait (HP:0002136)2.48833681
68Poor eye contact (HP:0000817)2.47797365
69Eczematoid dermatitis (HP:0000976)2.46707046
70Neuroendocrine neoplasm (HP:0100634)2.46033331
71Oral leukoplakia (HP:0002745)2.45709494
72Onion bulb formation (HP:0003383)2.45484146
73Sensory axonal neuropathy (HP:0003390)2.45012661
74Abnormal social behavior (HP:0012433)2.44273889
75Impaired social interactions (HP:0000735)2.44273889
76Abnormality of the corticospinal tract (HP:0002492)2.43524851
77Ulnar claw (HP:0001178)2.42534397
78Spastic gait (HP:0002064)2.40980837
79Rhabdomyosarcoma (HP:0002859)2.40702610
80Chromsome breakage (HP:0040012)2.40701701
81Postural instability (HP:0002172)2.40111836
82Exercise-induced muscle cramps (HP:0003710)2.38459799
83Ventricular fibrillation (HP:0001663)2.37802646
84Impaired vibration sensation in the lower limbs (HP:0002166)2.36858133
85Abnormality of serum amino acid levels (HP:0003112)2.35029825
86Failure to thrive in infancy (HP:0001531)2.34398171
87Excessive salivation (HP:0003781)2.30942513
88Drooling (HP:0002307)2.30942513
89Sparse eyelashes (HP:0000653)2.30753387
90Stenosis of the external auditory canal (HP:0000402)2.29677778
91Disinhibition (HP:0000734)2.28888931
92Urinary urgency (HP:0000012)2.27496719
93Facial cleft (HP:0002006)2.25453389
94Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.23521760
95Akinesia (HP:0002304)2.23462481
96Hypoglycemic seizures (HP:0002173)2.23044808
97Generalized myoclonic seizures (HP:0002123)2.23040551
98Limb dystonia (HP:0002451)2.20650830
99Right ventricular cardiomyopathy (HP:0011663)2.19968679
100Generalized hypotonia (HP:0001290)2.19812816
101Genetic anticipation (HP:0003743)2.19628759
102Hemiparesis (HP:0001269)2.19551021
103Hemiplegia (HP:0002301)2.18761978
104Septo-optic dysplasia (HP:0100842)2.15298163
105Aplasia/Hypoplasia of the breasts (HP:0010311)2.15064014
106Shoulder girdle muscle weakness (HP:0003547)2.13602513
107EEG with generalized epileptiform discharges (HP:0011198)2.13560649
108Biliary tract neoplasm (HP:0100574)2.13388569
109Epileptiform EEG discharges (HP:0011182)2.12719242
110Cerebral hemorrhage (HP:0001342)2.12597360
111Rough bone trabeculation (HP:0100670)2.11739863
112Hyperalaninemia (HP:0003348)2.09665541
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09665541
114Abnormality of alanine metabolism (HP:0010916)2.09665541
115Gastrointestinal carcinoma (HP:0002672)2.09611989
116Malignant gastrointestinal tract tumors (HP:0006749)2.09611989
117Abnormality of binocular vision (HP:0011514)2.08721952
118Diplopia (HP:0000651)2.08721952
119Hyperventilation (HP:0002883)2.08150920
120Agitation (HP:0000713)2.07830940
121Esophageal atresia (HP:0002032)2.07573120
122Gaze-evoked nystagmus (HP:0000640)2.07130899
123Breast aplasia (HP:0100783)2.06929238
124Lower limb muscle weakness (HP:0007340)2.06303300
125Abnormal hair whorl (HP:0010721)2.06146121
126Anosmia (HP:0000458)2.05648455
127Slow saccadic eye movements (HP:0000514)2.05471156
128Small intestinal stenosis (HP:0012848)2.05375835
129Duodenal stenosis (HP:0100867)2.05375835
130Amniotic constriction ring (HP:0009775)2.05323643
131Abnormality of placental membranes (HP:0011409)2.05323643
132Lower limb amyotrophy (HP:0007210)2.04547871
133Hypsarrhythmia (HP:0002521)2.03496860
134Abnormality of the preputium (HP:0100587)2.02494706
135Abnormality of salivation (HP:0100755)2.01977183
136Uterine neoplasm (HP:0010784)2.01251094
137Psychosis (HP:0000709)2.00838995
138Abnormality of chromosome stability (HP:0003220)2.00686264
139Amaurosis fugax (HP:0100576)2.00404261
140Apathy (HP:0000741)1.99455813
141Palmar hyperkeratosis (HP:0010765)1.98804335
142Hypoventilation (HP:0002791)1.97810366
143Skull defect (HP:0001362)1.96785873
144Myelomeningocele (HP:0002475)1.96506783
145Trismus (HP:0000211)1.95673862
146Bradykinesia (HP:0002067)1.95564075
147Premature loss of primary teeth (HP:0006323)1.95462689
148Medulloblastoma (HP:0002885)1.95177800
149Status epilepticus (HP:0002133)1.94887712
150Inappropriate behavior (HP:0000719)1.94622047
151Meckel diverticulum (HP:0002245)1.91657972
152Abnormal hair laboratory examination (HP:0003328)1.91543037
153Natal tooth (HP:0000695)1.91412834
154Pelvic girdle muscle weakness (HP:0003749)1.90076151
155Palmoplantar hyperkeratosis (HP:0000972)1.89745493
156Abnormal trabecular bone morphology (HP:0100671)1.89239342
157Nail dystrophy (HP:0008404)1.88938903
158Chronic bronchitis (HP:0004469)1.88286407
159Amblyopia (HP:0000646)1.86823307
160Microvesicular hepatic steatosis (HP:0001414)1.86258698
161Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85578001
162Degeneration of the lateral corticospinal tracts (HP:0002314)1.85578001
163Intention tremor (HP:0002080)1.85562984
164Deviation of the thumb (HP:0009603)1.85090580
165Fused cervical vertebrae (HP:0002949)1.84098599
166Absent hair (HP:0002298)1.83512316
167Abnormality of homocysteine metabolism (HP:0010919)1.83314246
168Homocystinuria (HP:0002156)1.83314246
169Scanning speech (HP:0002168)1.83033951
170Dysphonia (HP:0001618)1.81227940
171Increased nuchal translucency (HP:0010880)1.80551712
172Adrenal overactivity (HP:0002717)1.79712836
173Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79449894
174Aplasia cutis congenita (HP:0001057)1.79119360
175Esotropia (HP:0000565)1.78926825
176Stereotypic behavior (HP:0000733)1.78800149
177Decreased muscle mass (HP:0003199)1.78573919
178Dry hair (HP:0011359)1.78043146
179Neoplasm of the colon (HP:0100273)1.77861497
180Myocardial infarction (HP:0001658)1.77674255
181Decreased motor nerve conduction velocity (HP:0003431)1.76979043
182Neoplasm of the peripheral nervous system (HP:0100007)1.75943655
183Delusions (HP:0000746)1.75554609
184Type I diabetes mellitus (HP:0100651)1.74662609
185Absent radius (HP:0003974)1.73523479
186Abnormality of the ileum (HP:0001549)1.73360433
187Abnormality of saccadic eye movements (HP:0000570)1.72495542
188Abnormality of the duodenum (HP:0002246)1.72441039
189Hypoplastic female external genitalia (HP:0012815)1.72331366
190Cellular immunodeficiency (HP:0005374)1.72095068
191Diminished motivation (HP:0000745)1.71987835
192Increased IgE level (HP:0003212)1.71207983
193Torticollis (HP:0000473)1.70865500
194Death in infancy (HP:0001522)1.70058470
195Sensorimotor neuropathy (HP:0007141)1.68759815
196Cleft eyelid (HP:0000625)1.68573705
197Abnormality of the clitoris (HP:0000056)1.68045006
198Increased cerebral lipofuscin (HP:0011813)1.67528295
199Ridged nail (HP:0001807)1.67054376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.08767365
2NTRK34.08474571
3MAP3K93.62674057
4TSSK63.62437147
5TTK3.39700202
6CDC73.36342468
7MAP3K123.14740278
8MAP3K43.02099764
9MST42.95610381
10MARK12.85952412
11MINK12.69436520
12MAP2K72.62543456
13MKNK12.49552484
14PLK32.43763997
15MKNK22.43488246
16NME22.42349146
17SRPK12.34650644
18PBK2.33968261
19TAF12.18646426
20ZAK2.15798229
21NTRK22.15610903
22PAK62.14022488
23MAP3K142.03292389
24CASK2.03100060
25EPHA42.01662806
26NTRK12.00628037
27RIPK41.98960678
28MAP3K131.97498312
29VRK21.96469046
30PAK41.94678337
31MAP2K41.94114578
32DAPK21.94099478
33STK381.89881401
34BMPR21.85419640
35EPHA31.82811501
36STK241.77386402
37LATS21.69198073
38KSR21.64801337
39TRIM281.64521051
40DYRK31.54264627
41GRK51.51658686
42SMG11.50580719
43MAPK131.47771192
44UHMK11.46047421
45PLK11.45750003
46PLK41.45076451
47ERBB41.40421807
48NME11.36624151
49STK161.33595459
50CSF1R1.33017696
51CDK51.29520043
52GRK71.27688049
53ARAF1.24848017
54SIK21.20795820
55PLK21.17267540
56LMTK21.16233769
57EPHB11.14550238
58STK101.14383055
59FLT31.12555782
60CHEK21.11576047
61PASK1.11110940
62FER1.10793984
63MET1.09664242
64EIF2AK21.09334030
65ALK1.08086116
66CDK191.07540923
67RIPK11.05640837
68STK111.04653691
69MAP3K101.03493662
70FES1.01781783
71RET1.01259877
72BRSK21.00993775
73TNIK1.00694390
74CAMKK10.99769274
75PHKG20.99497819
76PHKG10.99497819
77MST1R0.99278631
78MAP3K80.96656451
79LATS10.94727657
80EIF2AK30.93093000
81CAMK2A0.91838513
82PAK30.90535186
83TNK20.89973600
84SCYL20.89649557
85PDGFRA0.86905512
86STK38L0.85377089
87STK30.85289360
88CDK60.84982187
89FGFR10.82594918
90VRK10.82168503
91RPS6KA40.81659394
92PRKCG0.81534544
93TGFBR10.80678798
94ATR0.79314435
95BRAF0.78630079
96KSR10.75046427
97PRKCE0.74632684
98PTK20.74069350
99CDC42BPA0.74027393
100PKN10.73558012
101PNCK0.73206411
102DAPK10.73182708
103CDK140.72316542
104AURKB0.71801850
105CHEK10.71798329
106CAMK1D0.71682400
107MAPKAPK50.69875358
108PRKCH0.69783758
109BMPR1B0.68611910
110MAP3K10.68530501
111TAOK20.67473667
112STK390.65995183
113FGR0.65069437
114EEF2K0.64308537
115OXSR10.63827814
116WEE10.63280177
117CAMK2B0.63226120
118JAK10.63167426
119IRAK10.62620821
120CDK180.62211410
121STK40.62081056
122PRKD30.61957857
123NEK20.61759141
124PINK10.61427690
125CDK150.60563335
126ABL20.60544695
127BMX0.59595312
128TTN0.58052096
129EPHA20.57916425
130NLK0.57797326
131CDK70.57584130
132CAMK1G0.57494758
133ATM0.56954184
134MAP3K20.56358352
135EPHB20.56307834
136CAMK2G0.54957546
137IRAK30.54300854
138FYN0.53906965
139MAP3K60.52100789
140CAMK2D0.51735067
141SGK10.51709983
142WNK10.51038210
143DYRK1A0.51024135
144CDK120.50361769
145DYRK20.49354169
146AURKA0.48493544
147CSNK1G10.48336977
148LIMK10.47813303
149WNK30.47805151
150CDK11A0.47534701
151FGFR40.46439962
152PIM10.46172840
153ERBB30.45904217
154HCK0.45607571
155PAK10.45425144
156ROCK20.44840157
157CSNK1G20.43712587
158JAK20.43457993
159SIK30.42854837
160DMPK0.42235342
161EGFR0.42234998
162BRD40.42033206
163PRKCZ0.41898728
164TESK20.40830246
165SGK2230.40561713
166SGK4940.40561713
167CAMK10.38706793
168RPS6KA20.37430643
169TYRO30.37344116
170KDR0.37228220
171SIK10.37035466
172YES10.36963733
173BCR0.36674541
174SYK0.36644793
175CDK10.36283114
176MOS0.36015668
177NEK10.35920715
178RPS6KA30.35266006
179CDK20.34572819
180BRSK10.33810357
181EIF2AK10.33350613
182NUAK10.33142878

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.77270100
2Nicotine addiction_Homo sapiens_hsa050333.69332768
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.53088154
4Proteasome_Homo sapiens_hsa030503.49967972
5Mismatch repair_Homo sapiens_hsa034303.43396835
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.14865647
7Synaptic vesicle cycle_Homo sapiens_hsa047213.10785264
8Non-homologous end-joining_Homo sapiens_hsa034502.85651017
9Spliceosome_Homo sapiens_hsa030402.71066466
10GABAergic synapse_Homo sapiens_hsa047272.68825168
11RNA transport_Homo sapiens_hsa030132.57794099
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54177893
13Cysteine and methionine metabolism_Homo sapiens_hsa002702.48476454
14RNA polymerase_Homo sapiens_hsa030202.45736739
15Olfactory transduction_Homo sapiens_hsa047402.42848569
16Cell cycle_Homo sapiens_hsa041102.41734024
17Morphine addiction_Homo sapiens_hsa050322.29214094
18Circadian entrainment_Homo sapiens_hsa047132.25076683
19Glutamatergic synapse_Homo sapiens_hsa047242.23199536
20One carbon pool by folate_Homo sapiens_hsa006702.22315183
21Base excision repair_Homo sapiens_hsa034102.10424807
22Long-term potentiation_Homo sapiens_hsa047202.03696426
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03645063
24Salivary secretion_Homo sapiens_hsa049701.98007054
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.95589768
26Amphetamine addiction_Homo sapiens_hsa050311.92264023
27Biosynthesis of amino acids_Homo sapiens_hsa012301.84466528
28Taste transduction_Homo sapiens_hsa047421.81512931
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.75816304
30Cholinergic synapse_Homo sapiens_hsa047251.74133990
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73591401
32Selenocompound metabolism_Homo sapiens_hsa004501.73485466
33Dopaminergic synapse_Homo sapiens_hsa047281.72409710
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72346673
35mRNA surveillance pathway_Homo sapiens_hsa030151.70390713
36Basal transcription factors_Homo sapiens_hsa030221.70349290
37Gastric acid secretion_Homo sapiens_hsa049711.70048886
38* Serotonergic synapse_Homo sapiens_hsa047261.66020865
39Adherens junction_Homo sapiens_hsa045201.65585391
40Nucleotide excision repair_Homo sapiens_hsa034201.60083289
41Collecting duct acid secretion_Homo sapiens_hsa049661.57572943
42Long-term depression_Homo sapiens_hsa047301.55483882
43Steroid biosynthesis_Homo sapiens_hsa001001.54881246
44RNA degradation_Homo sapiens_hsa030181.52639228
45Renin secretion_Homo sapiens_hsa049241.51918851
46Pyrimidine metabolism_Homo sapiens_hsa002401.51611111
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.47381990
48Vitamin B6 metabolism_Homo sapiens_hsa007501.46160359
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46087053
50Insulin secretion_Homo sapiens_hsa049111.40493787
51p53 signaling pathway_Homo sapiens_hsa041151.38572325
52Pyruvate metabolism_Homo sapiens_hsa006201.37792380
53Oxytocin signaling pathway_Homo sapiens_hsa049211.36927507
54GnRH signaling pathway_Homo sapiens_hsa049121.35983900
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35004795
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34962319
57Cocaine addiction_Homo sapiens_hsa050301.33335038
58Thyroid cancer_Homo sapiens_hsa052161.33223101
59Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32003574
60* Calcium signaling pathway_Homo sapiens_hsa040201.31376695
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30878544
62Protein export_Homo sapiens_hsa030601.30830430
63Homologous recombination_Homo sapiens_hsa034401.26886106
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24569259
65Estrogen signaling pathway_Homo sapiens_hsa049151.18022666
66Dorso-ventral axis formation_Homo sapiens_hsa043201.17717276
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17134332
68Cardiac muscle contraction_Homo sapiens_hsa042601.16558068
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15756855
70Carbon metabolism_Homo sapiens_hsa012001.09085827
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07933388
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07668590
73Vibrio cholerae infection_Homo sapiens_hsa051101.07028375
74* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06973570
75cAMP signaling pathway_Homo sapiens_hsa040241.02991713
76MicroRNAs in cancer_Homo sapiens_hsa052061.01212427
77Type II diabetes mellitus_Homo sapiens_hsa049301.00515399
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99082899
79Gap junction_Homo sapiens_hsa045400.98800881
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97050969
81Oxidative phosphorylation_Homo sapiens_hsa001900.94622846
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94091169
83Axon guidance_Homo sapiens_hsa043600.94063140
84Fanconi anemia pathway_Homo sapiens_hsa034600.93741091
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93626020
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.93085113
87Purine metabolism_Homo sapiens_hsa002300.89714655
88Tight junction_Homo sapiens_hsa045300.89212673
89Melanogenesis_Homo sapiens_hsa049160.88003324
90Bladder cancer_Homo sapiens_hsa052190.87192463
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86469279
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86058330
93Legionellosis_Homo sapiens_hsa051340.85705848
94Alzheimers disease_Homo sapiens_hsa050100.85614571
95Shigellosis_Homo sapiens_hsa051310.85396684
96Type I diabetes mellitus_Homo sapiens_hsa049400.84972421
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84838160
98ErbB signaling pathway_Homo sapiens_hsa040120.84327683
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82192533
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79903016
101Epstein-Barr virus infection_Homo sapiens_hsa051690.79397731
102Pentose phosphate pathway_Homo sapiens_hsa000300.79351053
103Glioma_Homo sapiens_hsa052140.79344772
104Chemokine signaling pathway_Homo sapiens_hsa040620.78593216
105Hippo signaling pathway_Homo sapiens_hsa043900.78189378
106Wnt signaling pathway_Homo sapiens_hsa043100.77913622
107Galactose metabolism_Homo sapiens_hsa000520.77054569
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75829737
109MAPK signaling pathway_Homo sapiens_hsa040100.75774493
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73940925
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.73549895
112Parkinsons disease_Homo sapiens_hsa050120.73030297
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.71949449
114Glutathione metabolism_Homo sapiens_hsa004800.68389175
115* Ras signaling pathway_Homo sapiens_hsa040140.67908845
116Dilated cardiomyopathy_Homo sapiens_hsa054140.67665431
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66147949
118Folate biosynthesis_Homo sapiens_hsa007900.65745697
119Rheumatoid arthritis_Homo sapiens_hsa053230.65536709
120Proteoglycans in cancer_Homo sapiens_hsa052050.65514941
121Ribosome_Homo sapiens_hsa030100.64937640
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62329586
123TGF-beta signaling pathway_Homo sapiens_hsa043500.61543344
124Pancreatic secretion_Homo sapiens_hsa049720.61494914
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60800814
126Small cell lung cancer_Homo sapiens_hsa052220.60771830
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60494574
128Thyroid hormone synthesis_Homo sapiens_hsa049180.59858778
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59705164
130ECM-receptor interaction_Homo sapiens_hsa045120.58974626
131Phagosome_Homo sapiens_hsa041450.58788871
132VEGF signaling pathway_Homo sapiens_hsa043700.58560675
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58099176
134African trypanosomiasis_Homo sapiens_hsa051430.58013014
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57962918
136Prolactin signaling pathway_Homo sapiens_hsa049170.56374004
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.55094933
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54803564
139Ovarian steroidogenesis_Homo sapiens_hsa049130.53978272
140Choline metabolism in cancer_Homo sapiens_hsa052310.53500994
141Colorectal cancer_Homo sapiens_hsa052100.52265753
142Ether lipid metabolism_Homo sapiens_hsa005650.51665392
143Oocyte meiosis_Homo sapiens_hsa041140.51519979
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50119282
145Fatty acid elongation_Homo sapiens_hsa000620.49781419
146Osteoclast differentiation_Homo sapiens_hsa043800.47179396
147Vitamin digestion and absorption_Homo sapiens_hsa049770.46748761
148Prion diseases_Homo sapiens_hsa050200.45810127
149Rap1 signaling pathway_Homo sapiens_hsa040150.45791242
150Tuberculosis_Homo sapiens_hsa051520.45580878
151Phototransduction_Homo sapiens_hsa047440.45493572
152Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45404339
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.44533222
154Huntingtons disease_Homo sapiens_hsa050160.44292814
155Herpes simplex infection_Homo sapiens_hsa051680.43694248
156Basal cell carcinoma_Homo sapiens_hsa052170.43151644
157Prostate cancer_Homo sapiens_hsa052150.42627048
158Sphingolipid metabolism_Homo sapiens_hsa006000.42388253
159Salmonella infection_Homo sapiens_hsa051320.42191738
160Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41917180
161Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41617502
162Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41616288
163Inositol phosphate metabolism_Homo sapiens_hsa005620.39716305
164Glucagon signaling pathway_Homo sapiens_hsa049220.39562003
165Endocytosis_Homo sapiens_hsa041440.39368754
166Apoptosis_Homo sapiens_hsa042100.39048219
167Renal cell carcinoma_Homo sapiens_hsa052110.39046539
168NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38750272
169Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38508304
170Amoebiasis_Homo sapiens_hsa051460.36304072
171Lysine degradation_Homo sapiens_hsa003100.36203741
172Viral carcinogenesis_Homo sapiens_hsa052030.35535666
173Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35200478
174SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34842609
175NF-kappa B signaling pathway_Homo sapiens_hsa040640.33791020
176Pathways in cancer_Homo sapiens_hsa052000.33027612
177Toxoplasmosis_Homo sapiens_hsa051450.32767993
178Focal adhesion_Homo sapiens_hsa045100.31522884
179Leishmaniasis_Homo sapiens_hsa051400.31405405
180Asthma_Homo sapiens_hsa053100.31300063
181Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30088216
182HTLV-I infection_Homo sapiens_hsa051660.28132833
183Viral myocarditis_Homo sapiens_hsa054160.27361158
184Lysosome_Homo sapiens_hsa041420.26587746
185Antigen processing and presentation_Homo sapiens_hsa046120.23024034
186Metabolic pathways_Homo sapiens_hsa011000.21221103
187N-Glycan biosynthesis_Homo sapiens_hsa005100.20370611
188Propanoate metabolism_Homo sapiens_hsa006400.19848369
189Arginine and proline metabolism_Homo sapiens_hsa003300.18230044
190Leukocyte transendothelial migration_Homo sapiens_hsa046700.17835197
191Melanoma_Homo sapiens_hsa052180.17523721

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