HTRA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alanine transport (GO:0032328)6.36818716
2L-serine transport (GO:0015825)5.41250424
3hemidesmosome assembly (GO:0031581)5.30823071
4negative regulation of astrocyte differentiation (GO:0048712)5.07917881
5positive regulation of cellular amide metabolic process (GO:0034250)4.97448861
6sodium ion export (GO:0071436)4.87499369
7cellular potassium ion homeostasis (GO:0030007)4.84983695
8C4-dicarboxylate transport (GO:0015740)4.77215066
9negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.72861433
10amino acid import (GO:0043090)4.69615252
11endodermal cell differentiation (GO:0035987)4.67970586
12serine transport (GO:0032329)4.63808458
13cell communication by electrical coupling (GO:0010644)4.59853875
14L-amino acid import (GO:0043092)4.51836953
15cellular response to cholesterol (GO:0071397)4.45953684
16regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.30670448
17glial cell proliferation (GO:0014009)4.21987064
18protein heterotrimerization (GO:0070208)4.13756665
19low-density lipoprotein particle remodeling (GO:0034374)4.13522784
20dermatan sulfate biosynthetic process (GO:0030208)4.13258140
21collagen fibril organization (GO:0030199)4.09032983
22chondroitin sulfate catabolic process (GO:0030207)4.04908399
23dermatan sulfate metabolic process (GO:0030205)4.04656587
24blood vessel maturation (GO:0001955)3.98828548
25regulation of beta-amyloid formation (GO:1902003)3.94624519
26negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.90882472
27cellular response to sterol (GO:0036315)3.87874045
28extracellular matrix assembly (GO:0085029)3.87196978
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.77917626
30adhesion of symbiont to host cell (GO:0044650)3.74776372
31virion attachment to host cell (GO:0019062)3.74776372
32regulation of phospholipid biosynthetic process (GO:0071071)3.73380783
33ovulation cycle (GO:0042698)3.73261853
34cellular sodium ion homeostasis (GO:0006883)3.72072792
35chondrocyte proliferation (GO:0035988)3.71834040
36neurotransmitter-gated ion channel clustering (GO:0072578)3.61899381
37potassium ion import (GO:0010107)3.55904679
38extracellular fibril organization (GO:0043206)3.53191081
39adhesion of symbiont to host (GO:0044406)3.51556454
40negative regulation of response to reactive oxygen species (GO:1901032)3.50400329
41cell migration involved in heart development (GO:0060973)3.49485219
42cell adhesion mediated by integrin (GO:0033627)3.47797248
43regulation of hydrogen peroxide-induced cell death (GO:1903205)3.45583225
44positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.43175674
45collagen metabolic process (GO:0032963)3.42829388
46skin morphogenesis (GO:0043589)3.41233944
47collagen catabolic process (GO:0030574)3.37346979
48proline transport (GO:0015824)3.37316556
49cell-substrate junction assembly (GO:0007044)3.36241581
50regulation of astrocyte differentiation (GO:0048710)3.34159548
51positive regulation of triglyceride biosynthetic process (GO:0010867)3.33787977
52positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.30094876
53regulation of amyloid precursor protein catabolic process (GO:1902991)3.28814120
54locomotory exploration behavior (GO:0035641)3.28227861
55keratan sulfate catabolic process (GO:0042340)3.26809010
56regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.26737339
57barbed-end actin filament capping (GO:0051016)3.26390163
58extracellular matrix disassembly (GO:0022617)3.21114492
59multicellular organismal macromolecule metabolic process (GO:0044259)3.19706258
60cGMP-mediated signaling (GO:0019934)3.16611666
61vascular endothelial growth factor signaling pathway (GO:0038084)3.16250357
62regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.14907245
63gamma-aminobutyric acid transport (GO:0015812)3.13392382
64regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.11073643
65sequestering of extracellular ligand from receptor (GO:0035581)3.09310121
66fibril organization (GO:0097435)3.08709878
67negative regulation of sodium ion transport (GO:0010766)3.08369642
68negative regulation of smoothened signaling pathway (GO:0045879)3.07024368
69retina vasculature morphogenesis in camera-type eye (GO:0061299)3.06498972
70multicellular organismal catabolic process (GO:0044243)3.06011735
71response to auditory stimulus (GO:0010996)3.05571732
72peripheral nervous system axon ensheathment (GO:0032292)3.03432625
73myelination in peripheral nervous system (GO:0022011)3.03432625
74apoptotic cell clearance (GO:0043277)3.02254641
75multicellular organismal metabolic process (GO:0044236)3.02232721
76potassium ion homeostasis (GO:0055075)3.01801554
77adenine nucleotide transport (GO:0051503)3.00095219
78positive regulation of osteoblast proliferation (GO:0033690)2.97710800
79basement membrane organization (GO:0071711)2.95856409
80lens fiber cell development (GO:0070307)2.92377280
81protein localization to endosome (GO:0036010)2.90519603
82regulation of extracellular matrix disassembly (GO:0010715)2.89967308
83atrial cardiac muscle cell action potential (GO:0086014)2.89368196
84extracellular matrix organization (GO:0030198)2.86351347
85extracellular structure organization (GO:0043062)2.85177825
86type B pancreatic cell proliferation (GO:0044342)2.85107495
87response to histamine (GO:0034776)2.84084658
88negative regulation of stress fiber assembly (GO:0051497)2.84083294
89regulation of glomerular filtration (GO:0003093)2.83415650
90regulation of membrane repolarization (GO:0060306)2.80561677
91synaptic vesicle docking involved in exocytosis (GO:0016081)2.80164948
92negative regulation of glial cell differentiation (GO:0045686)2.80103021
93stress fiber assembly (GO:0043149)2.79589851
94positive regulation of alcohol biosynthetic process (GO:1902932)2.76992510
95acidic amino acid transport (GO:0015800)2.76782812
96central nervous system myelination (GO:0022010)2.75607311
97axon ensheathment in central nervous system (GO:0032291)2.75607311
98substrate-dependent cell migration (GO:0006929)2.75575373
99G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74582547
100regulation of integrin-mediated signaling pathway (GO:2001044)2.74350317
101kidney mesenchyme development (GO:0072074)2.72164686
102glomerular basement membrane development (GO:0032836)2.71989435
103regulation of inositol phosphate biosynthetic process (GO:0010919)2.71084040
104cytoskeletal anchoring at plasma membrane (GO:0007016)2.70506214
105vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.69541141
106neurotransmitter uptake (GO:0001504)2.69033286
107regulation of cellular amide metabolic process (GO:0034248)2.68338345
108response to gravity (GO:0009629)2.68131397
109bone trabecula formation (GO:0060346)2.67411270
110positive regulation of potassium ion transmembrane transport (GO:1901381)2.67086821
111metanephric mesenchyme development (GO:0072075)2.67071384
112negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66867940
113peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.65954857
114venous blood vessel morphogenesis (GO:0048845)2.65818304
115cellular response to vitamin (GO:0071295)2.65484962
116membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.64896443
117response to cholesterol (GO:0070723)2.64262710
118negative regulation of chondrocyte differentiation (GO:0032331)2.63592816
119auditory behavior (GO:0031223)2.61110214
120glial cell migration (GO:0008347)2.60847611
121axon extension involved in axon guidance (GO:0048846)2.60395280
122neuron projection extension involved in neuron projection guidance (GO:1902284)2.60395280
123cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.60171752
124protein retention in ER lumen (GO:0006621)2.60066057
125peptidyl-proline hydroxylation (GO:0019511)2.59106807
126regulation of tight junction assembly (GO:2000810)2.57110387
127negative regulation of smooth muscle cell migration (GO:0014912)2.56386319
128regulation of triglyceride biosynthetic process (GO:0010866)2.54867542
129cellular modified amino acid catabolic process (GO:0042219)2.54516813
130chondrocyte development (GO:0002063)2.53548474
131positive regulation of axon extension (GO:0045773)2.52730295
132triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.52216769
133layer formation in cerebral cortex (GO:0021819)2.50965026
134response to dietary excess (GO:0002021)2.50329721
135neuroblast proliferation (GO:0007405)2.49811802
136dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.49768458
137regulation of cholesterol biosynthetic process (GO:0045540)2.48360267
138maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.48181991
139response to sterol (GO:0036314)2.47558306
140regulation of early endosome to late endosome transport (GO:2000641)2.47547749
141regulation of gonadotropin secretion (GO:0032276)2.47265781
142reverse cholesterol transport (GO:0043691)2.46670295
143purine nucleotide transport (GO:0015865)2.45511621
144negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.45415336
145mesenchymal-epithelial cell signaling (GO:0060638)2.45225863
146heart trabecula morphogenesis (GO:0061384)2.45170092
147cell communication involved in cardiac conduction (GO:0086065)2.44679238
148chondroitin sulfate metabolic process (GO:0030204)2.42376211
149positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.42364201
150renal filtration (GO:0097205)2.42362404
151anatomical structure maturation (GO:0071695)2.42280501
152daunorubicin metabolic process (GO:0044597)2.41995504
153polyketide metabolic process (GO:0030638)2.41995504
154doxorubicin metabolic process (GO:0044598)2.41995504
155positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.41882575
156endothelial cell chemotaxis (GO:0035767)2.41711173
157positive regulation of extracellular matrix organization (GO:1903055)2.40949319
158purine ribonucleotide transport (GO:0015868)2.40816632
159positive regulation of astrocyte differentiation (GO:0048711)2.40541014
160cholesterol catabolic process (GO:0006707)2.40214211
161sterol catabolic process (GO:0016127)2.40214211
162positive regulation of sodium ion transmembrane transport (GO:1902307)2.37718520
163chondroitin sulfate biosynthetic process (GO:0030206)2.37038015
164glycogen catabolic process (GO:0005980)2.37013522
165negative regulation of actin filament bundle assembly (GO:0032232)2.36945817
166smooth muscle tissue development (GO:0048745)2.36505701
167renal system process involved in regulation of blood volume (GO:0001977)2.34705381
168substrate adhesion-dependent cell spreading (GO:0034446)2.34029725
169membrane repolarization (GO:0086009)2.33589993
170phagocytosis, recognition (GO:0006910)2.33434246
171fatty acid homeostasis (GO:0055089)2.32371129
172cortical actin cytoskeleton organization (GO:0030866)2.32129776
173endothelial cell morphogenesis (GO:0001886)2.31590435
174positive regulation of receptor recycling (GO:0001921)2.31544707
175glycosaminoglycan catabolic process (GO:0006027)2.31418203
176semaphorin-plexin signaling pathway (GO:0071526)2.31035436
177negative regulation of catenin import into nucleus (GO:0035414)2.30784737
178regulation of plasminogen activation (GO:0010755)2.28156350
179import into cell (GO:0098657)2.27124899
180astrocyte development (GO:0014002)2.26924637
181cell-matrix adhesion (GO:0007160)2.26749843
182cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.26136174
183positive regulation of blood vessel endothelial cell migration (GO:0043536)2.25567883
184epithelial cell-cell adhesion (GO:0090136)2.25525978
185heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.23630121
186axon extension (GO:0048675)2.23448020
187positive regulation of endothelial cell apoptotic process (GO:2000353)2.23309353
188wound healing, spreading of epidermal cells (GO:0035313)2.23138918
189positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.22653561

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.86406204
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.81842268
3SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.63776006
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58851198
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.45796986
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41253078
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41253078
8* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37861673
9EZH2_22144423_ChIP-Seq_EOC_Human2.36565632
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30036472
11AR_21572438_ChIP-Seq_LNCaP_Human2.24804876
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23852217
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16504843
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.11509596
15RNF2_27304074_Chip-Seq_ESCs_Mouse2.08390136
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06904892
17* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06564002
18* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.00654107
19IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91351243
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88379083
21DROSHA_22980978_ChIP-Seq_HELA_Human1.83565933
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81171424
23* TRIM28_21343339_ChIP-Seq_HEK293_Human1.80687785
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.80144857
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.74526511
26* EZH2_27304074_Chip-Seq_ESCs_Mouse1.70900045
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70032535
28GBX2_23144817_ChIP-Seq_PC3_Human1.69956741
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66506361
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64993738
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63730878
32CLOCK_20551151_ChIP-Seq_293T_Human1.60779501
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.59018698
34* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53063745
35RXR_22108803_ChIP-Seq_LS180_Human1.52781658
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.50872137
37* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50491638
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.47162533
39TP53_16413492_ChIP-PET_HCT116_Human1.46601956
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46260410
41* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.46163200
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.45820557
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.44932361
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44368713
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39918565
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.38341270
47BRD4_25478319_ChIP-Seq_HGPS_Human1.38192295
48LXR_22292898_ChIP-Seq_THP-1_Human1.37058540
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.36510385
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.35585930
51* TP53_20018659_ChIP-ChIP_R1E_Mouse1.33836100
52REST_21632747_ChIP-Seq_MESCs_Mouse1.30258771
53* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29371918
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29353027
55SMC1_22415368_ChIP-Seq_MEFs_Mouse1.28459711
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27362650
57WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26719728
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26242322
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25514255
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23767285
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23445313
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23200425
63TCF4_18268006_ChIP-ChIP_LS174T_Human1.22861821
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22154088
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.21710468
66BCAT_22108803_ChIP-Seq_LS180_Human1.19896908
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.18983146
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18581589
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18529507
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18282428
71* TP53_18474530_ChIP-ChIP_U2OS_Human1.14380979
72TP53_23651856_ChIP-Seq_MEFs_Mouse1.14366599
73* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13389385
74ESR1_21235772_ChIP-Seq_MCF-7_Human1.13240747
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12256118
76* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12145616
77SA1_22415368_ChIP-Seq_MEFs_Mouse1.11851173
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10888006
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09875346
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08715323
81SMC3_22415368_ChIP-Seq_MEFs_Mouse1.08505484
82KDM2B_26808549_Chip-Seq_K562_Human1.08397327
83* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07923113
84* UBF1/2_26484160_Chip-Seq_HMECs_Human1.07166210
85P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07141772
86* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06623168
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06189754
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05793453
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05793453
90SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04976217
91SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04784142
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04784142
93PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04635126
94* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04224811
95DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02854134
96AR_25329375_ChIP-Seq_VCAP_Human1.02456855
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01507181
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00701715
99HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00541089
100* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00364941
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00137365
102ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99668220
103* CJUN_26792858_Chip-Seq_BT549_Human0.98582686
104* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98325206
105CBX2_27304074_Chip-Seq_ESCs_Mouse0.98196591
106* AR_19668381_ChIP-Seq_PC3_Human0.97765286
107REST_18959480_ChIP-ChIP_MESCs_Mouse0.97519387
108ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97307954
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96566035
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95875526
111RING1B_27294783_Chip-Seq_NPCs_Mouse0.95479495
112ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94920912
113ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93684350
114TBX20_22328084_ChIP-Seq_HEART_Mouse0.93338587
115TBX20_22080862_ChIP-Seq_HEART_Mouse0.93338587
116ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.92431164
117TP53_22127205_ChIP-Seq_IMR90_Human0.92103096
118ARNT_22903824_ChIP-Seq_MCF-7_Human0.92017214
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91890121
120* SOX2_21211035_ChIP-Seq_LN229_Gbm0.91723886
121TET1_21490601_ChIP-Seq_MESCs_Mouse0.91329989
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90459384
123CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90055770
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89443823
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89371635
126* SOX2_20726797_ChIP-Seq_SW620_Human0.87991223
127* SMAD4_21799915_ChIP-Seq_A2780_Human0.87607936
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86265696
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.86127429
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.86090827
131AHR_22903824_ChIP-Seq_MCF-7_Human0.85880632
132CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84798708
133KLF5_25053715_ChIP-Seq_YYC3_Human0.83868925
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.83592470
135YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83425089
136* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83402651
137* TP63_23658742_ChIP-Seq_EP156T_Human0.82932508
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80936895
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.80386750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.48164951
2MP0003329_amyloid_beta_deposits3.37874999
3MP0003279_aneurysm3.22090631
4MP0003690_abnormal_glial_cell3.15298956
5MP0009384_cardiac_valve_regurgitation3.06693778
6MP0004858_abnormal_nervous_system2.77401422
7MP0004885_abnormal_endolymph2.71862514
8MP0010368_abnormal_lymphatic_system2.53969902
9MP0005257_abnormal_intraocular_pressure2.44587751
10MP0009780_abnormal_chondrocyte_physiolo2.42813553
11MP0004859_abnormal_synaptic_plasticity2.40650778
12MP0008438_abnormal_cutaneous_collagen2.26428458
13MP0005377_hearing/vestibular/ear_phenot2.13036903
14MP0003878_abnormal_ear_physiology2.13036903
15MP0005646_abnormal_pituitary_gland2.08204212
16MP0009840_abnormal_foam_cell2.03626440
17MP0005623_abnormal_meninges_morphology2.00323537
18MP0000751_myopathy1.99250227
19MP0002060_abnormal_skin_morphology1.99178027
20MP0001486_abnormal_startle_reflex1.97521910
21MP0005023_abnormal_wound_healing1.95227414
22MP0000566_synostosis1.93699129
23MP0001502_abnormal_circadian_rhythm1.91882785
24MP0001958_emphysema1.89578732
25MP0004215_abnormal_myocardial_fiber1.87341207
26MP0002896_abnormal_bone_mineralization1.86208749
27MP0000604_amyloidosis1.83677655
28MP0006054_spinal_hemorrhage1.78403680
29MP0000767_abnormal_smooth_muscle1.77588367
30MP0003075_altered_response_to1.68670190
31MP0003635_abnormal_synaptic_transmissio1.68462802
32MP0003705_abnormal_hypodermis_morpholog1.66756882
33MP0002909_abnormal_adrenal_gland1.65084355
34MP0003634_abnormal_glial_cell1.60182296
35MP0005058_abnormal_lysosome_morphology1.53690417
36MP0001440_abnormal_grooming_behavior1.49173738
37MP0008569_lethality_at_weaning1.48027377
38MP0005275_abnormal_skin_tensile1.47640307
39MP0003283_abnormal_digestive_organ1.47255205
40MP0003137_abnormal_impulse_conducting1.44766024
41MP0009046_muscle_twitch1.43564411
42MP0010030_abnormal_orbit_morphology1.42280217
43MP0002127_abnormal_cardiovascular_syste1.40451355
44MP0001849_ear_inflammation1.38744599
45MP0004270_analgesia1.36817818
46MP0001853_heart_inflammation1.33527797
47MP0003633_abnormal_nervous_system1.32475502
48MP0004272_abnormal_basement_membrane1.31547778
49MP0000750_abnormal_muscle_regeneration1.28835772
50MP0005503_abnormal_tendon_morphology1.28288424
51MP0002064_seizures1.27518228
52MP0000762_abnormal_tongue_morphology1.25877228
53MP0004130_abnormal_muscle_cell1.25106516
54MP0000920_abnormal_myelination1.24443220
55MP0005670_abnormal_white_adipose1.24278847
56MP0001299_abnormal_eye_distance/1.23739524
57MP0002572_abnormal_emotion/affect_behav1.21322654
58MP0003941_abnormal_skin_development1.20180750
59MP0002063_abnormal_learning/memory/cond1.19614845
60MP0002998_abnormal_bone_remodeling1.16491244
61MP0002638_abnormal_pupillary_reflex1.16367361
62MP0005332_abnormal_amino_acid1.15440978
63MP0005167_abnormal_blood-brain_barrier1.15150596
64MP0002733_abnormal_thermal_nociception1.14586706
65MP0001879_abnormal_lymphatic_vessel1.14339682
66MP0002295_abnormal_pulmonary_circulatio1.13796485
67MP0003191_abnormal_cellular_cholesterol1.11678082
68MP0003631_nervous_system_phenotype1.10882383
69MP0009745_abnormal_behavioral_response1.10795756
70MP0005409_darkened_coat_color1.09727816
71MP0005165_increased_susceptibility_to1.08907286
72MP0003632_abnormal_nervous_system1.07990377
73MP0003646_muscle_fatigue1.07260477
74MP0002090_abnormal_vision1.06055934
75MP0002972_abnormal_cardiac_muscle1.05703415
76MP0003011_delayed_dark_adaptation1.05653994
77MP0003136_yellow_coat_color1.05539404
78MP0002089_abnormal_postnatal_growth/wei1.05270942
79MP0003566_abnormal_cell_adhesion1.04969118
80MP0005390_skeleton_phenotype1.04712765
81MP0000733_abnormal_muscle_development1.03550534
82MP0005595_abnormal_vascular_smooth1.01516797
83MP0001243_abnormal_dermal_layer1.01339467
84MP0000013_abnormal_adipose_tissue1.00161266
85MP0000003_abnormal_adipose_tissue0.99162768
86MP0005164_abnormal_response_to0.98876277
87MP0005423_abnormal_somatic_nervous0.98206297
88MP0005508_abnormal_skeleton_morphology0.97680075
89MP0001485_abnormal_pinna_reflex0.95866060
90MP0005388_respiratory_system_phenotype0.95772678
91MP0002133_abnormal_respiratory_system0.95772678
92MP0000759_abnormal_skeletal_muscle0.94818371
93MP0003091_abnormal_cell_migration0.94770563
94MP0000163_abnormal_cartilage_morphology0.93801643
95MP0001984_abnormal_olfaction0.93051362
96MP0004036_abnormal_muscle_relaxation0.92350386
97MP0000428_abnormal_craniofacial_morphol0.91822019
98MP0000049_abnormal_middle_ear0.91723135
99MP0005666_abnormal_adipose_tissue0.91555038
100MP0000467_abnormal_esophagus_morphology0.90997773
101MP0000343_altered_response_to0.89807876
102MP0005620_abnormal_muscle_contractility0.89666636
103MP0003828_pulmonary_edema0.89303917
104MP0001501_abnormal_sleep_pattern0.88615300
105MP0003300_gastrointestinal_ulcer0.88473967
106MP0002557_abnormal_social/conspecific_i0.88117243
107MP0000647_abnormal_sebaceous_gland0.87739131
108MP0002115_abnormal_skeleton_extremities0.86604049
109MP0009250_abnormal_appendicular_skeleto0.85456681
110MP0002108_abnormal_muscle_morphology0.84336906
111MP0002736_abnormal_nociception_after0.83834447
112MP0002734_abnormal_mechanical_nocicepti0.82337413
113MP0005551_abnormal_eye_electrophysiolog0.81635165
114MP0003448_altered_tumor_morphology0.80955277
115MP0002933_joint_inflammation0.80510349
116MP0001542_abnormal_bone_strength0.78734992
117MP0005375_adipose_tissue_phenotype0.77905546
118MP0003950_abnormal_plasma_membrane0.77851458
119MP0005379_endocrine/exocrine_gland_phen0.77141898
120MP0005171_absent_coat_pigmentation0.77001151
121MP0000747_muscle_weakness0.76945301
122MP0003453_abnormal_keratinocyte_physiol0.76535420
123MP0000534_abnormal_ureter_morphology0.76394280
124MP0000579_abnormal_nail_morphology0.76259197
125MP0006138_congestive_heart_failure0.75741968
126MP0001915_intracranial_hemorrhage0.73766828
127MP0000462_abnormal_digestive_system0.73759061
128MP0002113_abnormal_skeleton_development0.73408022
129MP0003385_abnormal_body_wall0.72536210
130MP0002249_abnormal_larynx_morphology0.72409963
131MP0009115_abnormal_fat_cell0.72383993
132MP0001533_abnormal_skeleton_physiology0.72147068
133MP0001970_abnormal_pain_threshold0.71187568
134MP0003795_abnormal_bone_structure0.71082380
135MP0004883_abnormal_blood_vessel0.70917189
136MP0005253_abnormal_eye_physiology0.70901174
137MP0004084_abnormal_cardiac_muscle0.70721097
138MP0005647_abnormal_sex_gland0.70504457
139MP0003045_fibrosis0.70171732
140MP0004233_abnormal_muscle_weight0.70082577
141MP0002971_abnormal_brown_adipose0.69708054
142MP0001177_atelectasis0.69539493
143MP0002067_abnormal_sensory_capabilities0.68999002
144MP0000749_muscle_degeneration0.68640979
145MP0002168_other_aberrant_phenotype0.68082228
146MP0009053_abnormal_anal_canal0.67230843
147MP0004510_myositis0.66664385
148MP0002128_abnormal_blood_circulation0.64188925
149MP0004087_abnormal_muscle_fiber0.63901922
150MP0001614_abnormal_blood_vessel0.62804594
151MP0000249_abnormal_blood_vessel0.59446796
152MP0002877_abnormal_melanocyte_morpholog0.57741710
153MP0010771_integument_phenotype0.56489418

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the extremities (HP:0009825)6.78328387
2Aplasia involving bones of the upper limbs (HP:0009823)6.78328387
3Aplasia of the phalanges of the hand (HP:0009802)6.78328387
4Megalencephaly (HP:0001355)6.31320293
5Neurofibrillary tangles (HP:0002185)4.80873644
6Vascular tortuosity (HP:0004948)4.17573634
7Hypoplastic left heart (HP:0004383)3.92949284
8Arterial tortuosity (HP:0005116)3.83997378
9Aortic aneurysm (HP:0004942)3.77802316
10Fragile skin (HP:0001030)3.76155704
11Cerebral inclusion bodies (HP:0100314)3.74166150
12Abnormality of the axillary hair (HP:0100134)3.65600423
13Abnormality of secondary sexual hair (HP:0009888)3.65600423
14Bladder diverticulum (HP:0000015)3.62638254
15Hemiparesis (HP:0001269)3.62139223
16Mesangial abnormality (HP:0001966)3.56628324
17Abnormality of binocular vision (HP:0011514)3.55118285
18Diplopia (HP:0000651)3.55118285
19Hemiplegia (HP:0002301)3.54571524
20Soft skin (HP:0000977)3.46253889
21Onycholysis (HP:0001806)3.45166765
22Vertebral compression fractures (HP:0002953)3.39932652
23Wormian bones (HP:0002645)3.39433117
24Short hallux (HP:0010109)3.26344357
25Cervical subluxation (HP:0003308)3.21906268
26Spinal rigidity (HP:0003306)3.12413274
27Neonatal short-limb short stature (HP:0008921)3.07078510
28Hypoplastic heart (HP:0001961)3.05026569
29Type 1 muscle fiber predominance (HP:0003803)3.01526823
30Aplasia/Hypoplasia of the hallux (HP:0008362)3.00366933
31Clumsiness (HP:0002312)2.99990381
32Spondylolisthesis (HP:0003302)2.95325316
33Humeroradial synostosis (HP:0003041)2.91759404
34Synostosis involving the elbow (HP:0003938)2.91759404
35Blue sclerae (HP:0000592)2.91149599
36Increased variability in muscle fiber diameter (HP:0003557)2.88433291
37Abnormality of the middle phalanges of the toes (HP:0010183)2.87091271
38Genu recurvatum (HP:0002816)2.84703272
39Dilatation of the ascending aorta (HP:0005111)2.75092018
40Abnormality of proline metabolism (HP:0010907)2.61617788
41Hydroxyprolinuria (HP:0003080)2.61617788
42Tetraparesis (HP:0002273)2.60827039
43Premature rupture of membranes (HP:0001788)2.58659187
44Slender build (HP:0001533)2.57330504
45Abnormality of the dental pulp (HP:0006479)2.53287952
46Broad metatarsal (HP:0001783)2.52497001
47Mixed hearing impairment (HP:0000410)2.51740952
48Peritonitis (HP:0002586)2.49329961
49Fibular aplasia (HP:0002990)2.48127874
50Osteolytic defects of the hand bones (HP:0009699)2.46885603
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.46885603
52Bowel diverticulosis (HP:0005222)2.46844681
53Protrusio acetabuli (HP:0003179)2.46445684
54Mild short stature (HP:0003502)2.44861127
55Adactyly (HP:0009776)2.44262917
56Long nose (HP:0003189)2.43917666
57Mitral regurgitation (HP:0001653)2.43721247
58Narrow nasal bridge (HP:0000446)2.41303131
59Coronal craniosynostosis (HP:0004440)2.40835748
60Bronchomalacia (HP:0002780)2.39696181
61Hyperextensible skin (HP:0000974)2.39166160
62Mitral valve prolapse (HP:0001634)2.38250136
63Mitral stenosis (HP:0001718)2.34230859
64Hyperglycinuria (HP:0003108)2.31229297
65Absent hair (HP:0002298)2.30610797
66Abnormality of skeletal muscle fiber size (HP:0012084)2.30563523
67Shallow orbits (HP:0000586)2.28019388
68Joint stiffness (HP:0001387)2.23397656
69Abnormality of nail color (HP:0100643)2.23118751
70Supranuclear gaze palsy (HP:0000605)2.22591164
71Atrophic scars (HP:0001075)2.21017552
72Wrist flexion contracture (HP:0001239)2.20402678
73Hypoalphalipoproteinemia (HP:0003233)2.19735471
74Joint laxity (HP:0001388)2.18617880
75Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.18158604
76Mildly elevated creatine phosphokinase (HP:0008180)2.17226412
77Abnormality of molar morphology (HP:0011070)2.16672836
78Abnormality of molar (HP:0011077)2.16672836
79Short middle phalanx of the 5th finger (HP:0004220)2.15102497
80Coxa vara (HP:0002812)2.12304502
81Aortic regurgitation (HP:0001659)2.11749866
82Absent frontal sinuses (HP:0002688)2.09426922
83Split foot (HP:0001839)2.09040612
84Abnormality of permanent molar morphology (HP:0011071)2.08132030
85Abnormality of the dental root (HP:0006486)2.08132030
86Taurodontia (HP:0000679)2.08132030
87Turricephaly (HP:0000262)2.06999574
88Ulnar bowing (HP:0003031)2.05936392
89Atrioventricular block (HP:0001678)2.05084028
90Overgrowth (HP:0001548)2.04832449
91Abnormality of liposaccharide metabolism (HP:0010968)2.04648707
92Abnormality of glycosphingolipid metabolism (HP:0004343)2.04648707
93Abnormality of glycolipid metabolism (HP:0010969)2.04648707
94Aneurysm (HP:0002617)2.04273690
95Increased connective tissue (HP:0009025)2.03015752
96Hypoplasia of the iris (HP:0007676)2.01791722
97Ectopia lentis (HP:0001083)2.01650076
98Exercise-induced myalgia (HP:0003738)2.00052730
99Absent toe (HP:0010760)1.99917152
100Natal tooth (HP:0000695)1.99366280
101Ovoid vertebral bodies (HP:0003300)1.98978216
102Abnormal delivery (HP:0001787)1.97090537
103Generalized amyotrophy (HP:0003700)1.96397900
104Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.96340237
105Milia (HP:0001056)1.96189862
106Selective tooth agenesis (HP:0001592)1.96096862
107Status epilepticus (HP:0002133)1.96078182
108Aortic valve stenosis (HP:0001650)1.95809123
109Facial shape deformation (HP:0011334)1.94536512
110Potter facies (HP:0002009)1.94536512
111Follicular hyperkeratosis (HP:0007502)1.94398335
112Abnormality of the acetabulum (HP:0003170)1.94079009
113Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.92284068
114Elbow flexion contracture (HP:0002987)1.92039448
115Abnormality of serine family amino acid metabolism (HP:0010894)1.90308290
116Abnormality of glycine metabolism (HP:0010895)1.90308290
117Wide anterior fontanel (HP:0000260)1.89536738
118Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.89457196
119Abnormality of dentin (HP:0010299)1.89071119
120Systemic lupus erythematosus (HP:0002725)1.88882911
121Craniofacial hyperostosis (HP:0004493)1.88339302
122Complement deficiency (HP:0004431)1.87507432
123Dysostosis multiplex (HP:0000943)1.86717644
124Cupped ribs (HP:0000887)1.86515060
125Spinal cord compression (HP:0002176)1.85602350
126Round ear (HP:0100830)1.85581809
127Osteoarthritis (HP:0002758)1.84876162
128Limited hip movement (HP:0008800)1.84487773
129Biconcave vertebral bodies (HP:0004586)1.83860830
130Abnormality of complement system (HP:0005339)1.81253695
131Obstructive sleep apnea (HP:0002870)1.80064422
132Nuclear cataract (HP:0100018)1.79893754
133Heart block (HP:0012722)1.79862061
134Myokymia (HP:0002411)1.79641430
135Hypoventilation (HP:0002791)1.78652754
136Distal upper limb amyotrophy (HP:0007149)1.78417489
137Upper limb amyotrophy (HP:0009129)1.78417489
138Abnormal atrioventricular conduction (HP:0005150)1.76562187
139Venous abnormality (HP:0002624)1.76229085
140Short nail (HP:0001799)1.76160060
141Tibial bowing (HP:0002982)1.76025564
142Action tremor (HP:0002345)1.75569594
143Broad hallux (HP:0010055)1.75513178
144Ankle contracture (HP:0006466)1.75352830
145Symphalangism affecting the phalanges of the hand (HP:0009773)1.75244338
146Flared iliac wings (HP:0002869)1.74866115
147Epileptic encephalopathy (HP:0200134)1.74736802
148Tarsal synostosis (HP:0008368)1.74611702
149Aortic dissection (HP:0002647)1.73309143
150Mucopolysacchariduria (HP:0008155)1.73214684
151Urinary glycosaminoglycan excretion (HP:0003541)1.73214684
152Abnormality of the phalanges of the 5th finger (HP:0004213)1.72805839
153Focal motor seizures (HP:0011153)1.71611520
154Pterygium (HP:0001059)1.70642480
155Popliteal pterygium (HP:0009756)1.70590008
156Cerebral aneurysm (HP:0004944)1.70521613
157Venous insufficiency (HP:0005293)1.69700679
158Abnormal urine output (HP:0012590)1.69424454
159Cardiovascular calcification (HP:0011915)1.68972211
160Axonal loss (HP:0003447)1.68793109
161Abnormality of mucopolysaccharide metabolism (HP:0011020)1.68766110
162Abnormality of polysaccharide metabolism (HP:0011012)1.68766110
163Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68766110
164Fragile nails (HP:0001808)1.68492915
165Maternal diabetes (HP:0009800)1.67703126
166Broad ribs (HP:0000885)1.67021185
167Confusion (HP:0001289)1.65720715
168Multifactorial inheritance (HP:0001426)1.64727971
169Athetosis (HP:0002305)1.64244833
170Cranial hyperostosis (HP:0004437)1.61868281
171Synostosis involving bones of the lower limbs (HP:0009138)1.61279402
172Synostosis involving bones of the feet (HP:0009140)1.61279402
173Abnormality of the phalanges of the 2nd finger (HP:0009541)1.61179598
174Asymmetric septal hypertrophy (HP:0001670)1.61152625
175Infantile muscular hypotonia (HP:0008947)1.58318085
176Blepharitis (HP:0000498)1.58046563
177Xanthomatosis (HP:0000991)1.56481828
178Aplasia/Hypoplasia of the fibula (HP:0006492)1.55874611
179Polygenic inheritance (HP:0010982)1.55559332

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.52406001
2LMTK25.42128514
3PHKG24.00874196
4PHKG14.00874196
5TRIB33.57932872
6MUSK3.09054546
7TGFBR22.73755911
8TNIK2.52149612
9PRKD32.51168481
10MOS2.33886412
11SIK12.28420813
12NTRK22.20604327
13ARAF2.16980392
14DDR22.06072759
15TESK11.98329535
16LIMK11.72750909
17MAPK121.66658908
18NTRK31.59189222
19PAK21.54997322
20TIE11.54143070
21MARK11.50920918
22NEK91.49059309
23PDGFRA1.49038469
24PAK41.47834555
25RIPK11.43909750
26BMX1.29465419
27PIM21.28170877
28TTN1.27869522
29NTRK11.21241346
30ABL21.20599668
31MINK11.18068395
32ADRBK11.17525669
33DMPK1.16458525
34SGK2231.10978835
35SGK4941.10978835
36STK381.09969817
37LATS21.04697709
38SGK21.03712836
39PAK61.02311183
40SGK31.02168886
41PDK31.01995366
42PDK41.01995366
43PAK31.00400846
44MAP3K90.96715671
45ROCK10.95063222
46TYRO30.91557995
47CAMK1D0.91141953
48FGR0.87700985
49KSR20.86764344
50FGFR10.85722165
51FGFR20.84812006
52PINK10.84197569
53DAPK30.83665210
54RPS6KA20.81781315
55PRKCG0.81752298
56ERN10.80022032
57MAP3K60.79864046
58CAMK1G0.78414876
59CAMKK10.77340575
60MARK20.76873407
61CDK50.76404610
62MAP3K130.75829928
63EPHB20.74722565
64PRKCH0.73153327
65ICK0.73009920
66PRPF4B0.72861802
67MAPK70.72188606
68CAMK2B0.72073506
69ROCK20.71871788
70FER0.71682811
71PRKG20.71256568
72TNK20.70471259
73PRKCE0.69781416
74ERBB40.68731538
75JAK10.68483021
76MET0.68423052
77PTK2B0.67872959
78MAPK130.66698350
79CAMK2A0.65813583
80CDC42BPA0.65754703
81BCKDK0.65543154
82MAP3K40.65120759
83UHMK10.62716510
84MAP3K70.61033263
85LRRK20.61019998
86PDK20.60506117
87PRKD20.60395109
88TRPM70.59549094
89DAPK20.59513906
90GRK50.59425364
91PKN10.58262278
92MAP3K30.58078758
93CAMK2D0.57566854
94WNK40.56552121
95MTOR0.55665400
96PTK20.53794254
97MAPK40.53016356
98PTK60.52396312
99FGFR30.52394786
100MAP2K10.52273986
101PIK3CG0.51693592
102GSK3A0.51607689
103CASK0.51352082
104MYLK0.50874709
105EPHB10.49957378
106PKN20.49840177
107PRKD10.49671061
108CAMK10.49437499
109FGFR40.48340294
110IGF1R0.47393568
111PDPK10.47337171
112OXSR10.46776409
113SGK10.46593467
114SRC0.45726440
115CDK11A0.45264540
116MAPKAPK50.44731410
117TGFBR10.44640252
118PLK20.44249569
119TAOK20.44187156
120LATS10.44119890
121PRKAA20.44027702
122RET0.43506052
123WNK10.42933071
124DYRK1A0.41840949
125KIT0.41815645
126CDK150.41775578
127MAPKAPK30.41565822
128PRKACG0.41444118
129CDK140.41209340
130GRK60.40915496
131ILK0.40771963
132MST1R0.40266511
133CAMK2G0.40221234
134BRAF0.39628892
135PRKCA0.38718879
136MAP3K20.38493118
137IRAK30.37305303
138CDK180.37227290
139PRKACA0.37160804
140AKT20.35931989
141RPS6KA30.35572581
142PRKAA10.35053296
143PDGFRB0.33256613

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.95598530
2Nitrogen metabolism_Homo sapiens_hsa009104.71439687
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.24505319
4Fatty acid metabolism_Homo sapiens_hsa012122.66194460
5Fatty acid degradation_Homo sapiens_hsa000712.34215934
6Prion diseases_Homo sapiens_hsa050201.94313232
7Amoebiasis_Homo sapiens_hsa051461.84436129
8Other glycan degradation_Homo sapiens_hsa005111.70596122
9PPAR signaling pathway_Homo sapiens_hsa033201.70500784
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.62029481
11Nicotine addiction_Homo sapiens_hsa050331.55063927
12Propanoate metabolism_Homo sapiens_hsa006401.51714922
13Salivary secretion_Homo sapiens_hsa049701.47507724
14Gastric acid secretion_Homo sapiens_hsa049711.41237315
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39436691
16Glutamatergic synapse_Homo sapiens_hsa047241.37988216
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36287704
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34711548
19GABAergic synapse_Homo sapiens_hsa047271.30910119
20Complement and coagulation cascades_Homo sapiens_hsa046101.23456488
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22642645
22ECM-receptor interaction_Homo sapiens_hsa045121.21678990
23Regulation of actin cytoskeleton_Homo sapiens_hsa048101.18037303
24Circadian rhythm_Homo sapiens_hsa047101.16003918
25PI3K-Akt signaling pathway_Homo sapiens_hsa041511.15254540
26Steroid biosynthesis_Homo sapiens_hsa001001.14556026
27Insulin secretion_Homo sapiens_hsa049111.13626999
28Dilated cardiomyopathy_Homo sapiens_hsa054141.13226871
29Bile secretion_Homo sapiens_hsa049761.12841449
30Glioma_Homo sapiens_hsa052141.06737141
31Cocaine addiction_Homo sapiens_hsa050301.06634244
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06581774
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06249560
34Circadian entrainment_Homo sapiens_hsa047131.05232903
35Small cell lung cancer_Homo sapiens_hsa052221.02767462
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.00333625
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99543454
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97446285
39Estrogen signaling pathway_Homo sapiens_hsa049150.96589533
40Calcium signaling pathway_Homo sapiens_hsa040200.96563221
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95043186
42Fructose and mannose metabolism_Homo sapiens_hsa000510.94396333
43Mineral absorption_Homo sapiens_hsa049780.92870788
44Adherens junction_Homo sapiens_hsa045200.90917593
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89846787
46Long-term potentiation_Homo sapiens_hsa047200.88361868
47Vibrio cholerae infection_Homo sapiens_hsa051100.87753059
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87678838
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87491604
50Bladder cancer_Homo sapiens_hsa052190.87284682
51Olfactory transduction_Homo sapiens_hsa047400.85967543
52cAMP signaling pathway_Homo sapiens_hsa040240.85637631
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85230959
54Morphine addiction_Homo sapiens_hsa050320.83768342
55Basal cell carcinoma_Homo sapiens_hsa052170.83387654
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.83148047
57Dorso-ventral axis formation_Homo sapiens_hsa043200.83010632
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82897187
59Sulfur metabolism_Homo sapiens_hsa009200.82502853
60Melanoma_Homo sapiens_hsa052180.82336874
61Glycerolipid metabolism_Homo sapiens_hsa005610.79074810
62Pertussis_Homo sapiens_hsa051330.78917291
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78364857
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78328541
65Protein digestion and absorption_Homo sapiens_hsa049740.77667973
66Ovarian steroidogenesis_Homo sapiens_hsa049130.75629386
67TGF-beta signaling pathway_Homo sapiens_hsa043500.75484935
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74047486
69Arginine and proline metabolism_Homo sapiens_hsa003300.73333445
70Melanogenesis_Homo sapiens_hsa049160.72967955
71Carbon metabolism_Homo sapiens_hsa012000.72963039
72Cardiac muscle contraction_Homo sapiens_hsa042600.72955781
73Focal adhesion_Homo sapiens_hsa045100.72114893
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71749830
75Endocytosis_Homo sapiens_hsa041440.71595736
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71504611
77Renin secretion_Homo sapiens_hsa049240.71268948
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.71167098
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.70628590
80Ras signaling pathway_Homo sapiens_hsa040140.70046562
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69254101
82Gap junction_Homo sapiens_hsa045400.68998743
83Chronic myeloid leukemia_Homo sapiens_hsa052200.68789754
84Biosynthesis of amino acids_Homo sapiens_hsa012300.68426729
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68098968
86VEGF signaling pathway_Homo sapiens_hsa043700.66423740
87Lysosome_Homo sapiens_hsa041420.66411196
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65985630
89Proteoglycans in cancer_Homo sapiens_hsa052050.65949403
90Thyroid hormone synthesis_Homo sapiens_hsa049180.65739095
91Pathways in cancer_Homo sapiens_hsa052000.65559092
92Peroxisome_Homo sapiens_hsa041460.65421066
93Phagosome_Homo sapiens_hsa041450.65278167
94Hedgehog signaling pathway_Homo sapiens_hsa043400.64929390
95Vitamin B6 metabolism_Homo sapiens_hsa007500.64759738
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64595608
97Renal cell carcinoma_Homo sapiens_hsa052110.64427823
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.62477038
99Pancreatic secretion_Homo sapiens_hsa049720.61470957
100Notch signaling pathway_Homo sapiens_hsa043300.61003041
101MicroRNAs in cancer_Homo sapiens_hsa052060.60161022
102Pyruvate metabolism_Homo sapiens_hsa006200.60151567
103Pentose phosphate pathway_Homo sapiens_hsa000300.60141382
104ErbB signaling pathway_Homo sapiens_hsa040120.59752059
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59588479
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.59436824
107Synaptic vesicle cycle_Homo sapiens_hsa047210.59046508
108Histidine metabolism_Homo sapiens_hsa003400.58227223
109Amphetamine addiction_Homo sapiens_hsa050310.58030054
110Glucagon signaling pathway_Homo sapiens_hsa049220.57651058
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57246588
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56909225
113GnRH signaling pathway_Homo sapiens_hsa049120.56055272
114Toxoplasmosis_Homo sapiens_hsa051450.55982452
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55293200
116Fatty acid elongation_Homo sapiens_hsa000620.55276752
117Rap1 signaling pathway_Homo sapiens_hsa040150.54020775
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53647752
119AMPK signaling pathway_Homo sapiens_hsa041520.53382949
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53342964
121Butanoate metabolism_Homo sapiens_hsa006500.52627655
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52537276
123Cholinergic synapse_Homo sapiens_hsa047250.52507293
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.51837571
125Sulfur relay system_Homo sapiens_hsa041220.50820972
126Pancreatic cancer_Homo sapiens_hsa052120.49888929
127Axon guidance_Homo sapiens_hsa043600.49496378
128Sphingolipid metabolism_Homo sapiens_hsa006000.49021623
129Dopaminergic synapse_Homo sapiens_hsa047280.49016343
130Oxytocin signaling pathway_Homo sapiens_hsa049210.48405919
131Taste transduction_Homo sapiens_hsa047420.48034504
132Malaria_Homo sapiens_hsa051440.47941343
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.47898932
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.46973656
135Endometrial cancer_Homo sapiens_hsa052130.45963198
136Long-term depression_Homo sapiens_hsa047300.45905155
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45419518
138Starch and sucrose metabolism_Homo sapiens_hsa005000.44284993
139Hippo signaling pathway_Homo sapiens_hsa043900.44231731
140Serotonergic synapse_Homo sapiens_hsa047260.43565274

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