HTRA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of respiratory burst (GO:0060267)8.91283515
2negative regulation of protein activation cascade (GO:2000258)8.86465230
3negative regulation of humoral immune response (GO:0002921)7.27881849
4opsonization (GO:0008228)6.08633012
5detection of molecule of bacterial origin (GO:0032490)5.32059243
6protein heterotrimerization (GO:0070208)5.26466361
7basement membrane organization (GO:0071711)5.00252854
8keratan sulfate catabolic process (GO:0042340)4.93827747
9regulation of complement activation (GO:0030449)4.80650457
10collagen fibril organization (GO:0030199)4.51498986
11endothelium development (GO:0003158)4.34104392
12regulation of protein activation cascade (GO:2000257)4.32806358
13ovulation from ovarian follicle (GO:0001542)4.27083326
14cell migration involved in heart development (GO:0060973)4.24996385
15positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.16860992
16regulation of apoptotic cell clearance (GO:2000425)4.15761356
17angiogenesis involved in wound healing (GO:0060055)4.11394260
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.07506585
19cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.99085196
20regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.95386307
21positive regulation of p38MAPK cascade (GO:1900745)3.89867102
22adhesion of symbiont to host (GO:0044406)3.86521896
23negative regulation of heart growth (GO:0061117)3.81222389
24negative regulation of cardiac muscle tissue growth (GO:0055022)3.81222389
25collagen catabolic process (GO:0030574)3.69260264
26sequestering of extracellular ligand from receptor (GO:0035581)3.66411903
27leukocyte migration involved in inflammatory response (GO:0002523)3.66293215
28collagen metabolic process (GO:0032963)3.65010661
29negative regulation of leukocyte chemotaxis (GO:0002689)3.61872205
30barbed-end actin filament capping (GO:0051016)3.61518414
31positive regulation of macrophage activation (GO:0043032)3.55718947
32regulation of respiratory burst (GO:0060263)3.53538918
33atrioventricular valve morphogenesis (GO:0003181)3.53429751
34multicellular organismal macromolecule metabolic process (GO:0044259)3.50910768
35extracellular fibril organization (GO:0043206)3.49048758
36hydrogen peroxide catabolic process (GO:0042744)3.46374606
37multicellular organismal catabolic process (GO:0044243)3.43176232
38positive regulation of receptor recycling (GO:0001921)3.39255495
39glomerular basement membrane development (GO:0032836)3.37824778
40regulation of p38MAPK cascade (GO:1900744)3.35676259
41multicellular organismal metabolic process (GO:0044236)3.35408938
42branching involved in salivary gland morphogenesis (GO:0060445)3.34619849
43glomerular filtration (GO:0003094)3.22729654
44plasma membrane repair (GO:0001778)3.20205293
45response to hydroperoxide (GO:0033194)3.19580420
46cellular hyperosmotic response (GO:0071474)3.16566081
47cGMP biosynthetic process (GO:0006182)3.16391968
48regulation of macrophage chemotaxis (GO:0010758)3.15074441
49lymphangiogenesis (GO:0001946)3.14482465
50pathway-restricted SMAD protein phosphorylation (GO:0060389)3.12786441
51peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.11673112
52detection of external biotic stimulus (GO:0098581)3.08622587
53positive regulation of hair cycle (GO:0042635)3.08453381
54positive regulation of hair follicle development (GO:0051798)3.08453381
55apoptotic cell clearance (GO:0043277)3.07868184
56wound healing, spreading of epidermal cells (GO:0035313)3.06255353
57lymph vessel development (GO:0001945)3.05376704
58extracellular matrix disassembly (GO:0022617)3.04294286
59brown fat cell differentiation (GO:0050873)3.03714354
60vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.03665232
61virion attachment to host cell (GO:0019062)3.03588337
62adhesion of symbiont to host cell (GO:0044650)3.03588337
63endodermal cell differentiation (GO:0035987)3.02161811
64actin-mediated cell contraction (GO:0070252)2.99875951
65sarcomere organization (GO:0045214)2.96342585
66fibril organization (GO:0097435)2.95589216
67positive regulation of cellular response to insulin stimulus (GO:1900078)2.95450476
68positive regulation of osteoblast proliferation (GO:0033690)2.95168393
69regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.92796427
70renal filtration (GO:0097205)2.91793067
71vascular endothelial growth factor signaling pathway (GO:0038084)2.90516041
72regulation of integrin-mediated signaling pathway (GO:2001044)2.88719810
73regulation of sequestering of triglyceride (GO:0010889)2.87968752
74low-density lipoprotein particle clearance (GO:0034383)2.86329090
75regulation of macrophage cytokine production (GO:0010935)2.85804390
76negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.82617329
77regulation of glucose import in response to insulin stimulus (GO:2001273)2.81734388
78cardiac muscle cell proliferation (GO:0060038)2.81616250
79cellular response to epinephrine stimulus (GO:0071872)2.79816166
80skin morphogenesis (GO:0043589)2.78340542
81phagocytosis, recognition (GO:0006910)2.77169736
82cardiac myofibril assembly (GO:0055003)2.76837541
83actin-myosin filament sliding (GO:0033275)2.75436681
84muscle filament sliding (GO:0030049)2.75436681
85positive regulation of endothelial cell apoptotic process (GO:2000353)2.75264392
86blood vessel maturation (GO:0001955)2.74653794
87cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.71868929
88negative regulation of catenin import into nucleus (GO:0035414)2.70781506
89carnitine shuttle (GO:0006853)2.70084128
90cellular response to osmotic stress (GO:0071470)2.69541596
91stress fiber assembly (GO:0043149)2.69472357
92negative regulation of fatty acid transport (GO:2000192)2.69181760
93regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.69168180
94regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.68825223
95endothelial cell chemotaxis (GO:0035767)2.68221621
96positive regulation of chondrocyte differentiation (GO:0032332)2.66111775
97fibroblast migration (GO:0010761)2.65429501
98negative regulation of chondrocyte differentiation (GO:0032331)2.64744433
99endothelial cell morphogenesis (GO:0001886)2.64589031
100retina vasculature morphogenesis in camera-type eye (GO:0061299)2.62676705
101fatty acid transmembrane transport (GO:1902001)2.62167257
102cell-substrate junction assembly (GO:0007044)2.61126632
103chondrocyte proliferation (GO:0035988)2.60780408
104sulfur compound catabolic process (GO:0044273)2.59141661
105regulation of T cell tolerance induction (GO:0002664)2.58789234
106macrophage activation involved in immune response (GO:0002281)2.58446837
107negative regulation of blood vessel endothelial cell migration (GO:0043537)2.57594725
108regulation of humoral immune response (GO:0002920)2.57155201
109inner ear receptor cell development (GO:0060119)2.56760918
110detection of biotic stimulus (GO:0009595)2.56232764
111heart trabecula formation (GO:0060347)2.55624982
112myofibril assembly (GO:0030239)2.54749374
113cellular response to cadmium ion (GO:0071276)2.54610450
114negative regulation of cartilage development (GO:0061037)2.53090791
115glial cell migration (GO:0008347)2.52564969
116glycoprotein catabolic process (GO:0006516)2.51826490
117extracellular matrix assembly (GO:0085029)2.51588138
118negative regulation of innate immune response (GO:0045824)2.51204863
119positive regulation of fatty acid oxidation (GO:0046321)2.50639414
120chondroitin sulfate biosynthetic process (GO:0030206)2.49652451
121positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.48849636
122epithelial cell-cell adhesion (GO:0090136)2.48676214
123gland morphogenesis (GO:0022612)2.48472664
124cardiac muscle contraction (GO:0060048)2.48155763
125regulation of transforming growth factor beta2 production (GO:0032909)2.47554808
126uterus development (GO:0060065)2.47336470
127trabecula formation (GO:0060343)2.47298802
128ovulation (GO:0030728)2.46967419
129actomyosin structure organization (GO:0031032)2.46627056
130extracellular matrix organization (GO:0030198)2.46510666
131actin filament-based movement (GO:0030048)2.46424342
132positive regulation of protein kinase C signaling (GO:0090037)2.45994804
133regulation of cardioblast differentiation (GO:0051890)2.45940263
134extracellular structure organization (GO:0043062)2.45493594
135dermatan sulfate metabolic process (GO:0030205)2.45101621
136regulation of membrane protein ectodomain proteolysis (GO:0051043)2.44980636
137hemidesmosome assembly (GO:0031581)2.44861377
138adherens junction assembly (GO:0034333)2.44839289
139regulation of fatty acid oxidation (GO:0046320)2.44468554
140regulation of tight junction assembly (GO:2000810)2.44151176
141metanephric mesenchyme development (GO:0072075)2.41913978
142positive regulation of blood vessel endothelial cell migration (GO:0043536)2.41224830
143muscle hypertrophy (GO:0014896)2.39590309
144negative regulation of focal adhesion assembly (GO:0051895)2.37829654
145negative regulation of cell junction assembly (GO:1901889)2.37829654
146negative regulation of adherens junction organization (GO:1903392)2.37829654
147endothelial cell proliferation (GO:0001935)2.37371099
148regulation of cholesterol storage (GO:0010885)2.35992325
149venous blood vessel morphogenesis (GO:0048845)2.35222967
150response to epinephrine (GO:0071871)2.34268338
151cardiac muscle tissue morphogenesis (GO:0055008)2.33623165
152cardiac muscle hypertrophy (GO:0003300)2.33341768
153bundle of His cell to Purkinje myocyte communication (GO:0086069)2.32098406
154dermatan sulfate biosynthetic process (GO:0030208)2.31248812
155regulation of transforming growth factor beta1 production (GO:0032908)2.31207447
156cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.30334520
157positive regulation of odontogenesis (GO:0042482)2.29538477
158cell proliferation involved in metanephros development (GO:0072203)2.28212936
159chondroitin sulfate catabolic process (GO:0030207)2.27973490
160muscle tissue morphogenesis (GO:0060415)2.27804038
161negative regulation of complement activation (GO:0045916)10.7508412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.22998553
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.96193605
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.73460811
4CLOCK_20551151_ChIP-Seq_293T_Human3.44225239
5ESR1_22446102_ChIP-Seq_UTERUS_Mouse3.26155015
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.92882709
7* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.74997267
8CDX2_19796622_ChIP-Seq_MESCs_Mouse2.48406404
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.44135804
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.27145805
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.18055398
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.10927248
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.07623250
14CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.06228967
15BP1_19119308_ChIP-ChIP_Hs578T_Human1.99955900
16* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.85729444
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.80690401
18GATA2_21666600_ChIP-Seq_HMVEC_Human1.80603984
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78451807
20* TBX20_22080862_ChIP-Seq_HEART_Mouse1.74399285
21* TBX20_22328084_ChIP-Seq_HEART_Mouse1.74399285
22BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.71594009
23* ELK3_25401928_ChIP-Seq_HUVEC_Human1.69741721
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66673581
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66430969
26CJUN_26792858_Chip-Seq_BT549_Human1.64518612
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.57715969
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.57563606
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54777310
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54777310
31LXR_22158963_ChIP-Seq_LIVER_Mouse1.53890508
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.53759050
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.53130658
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50603016
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.50516660
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50437980
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43357458
38* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41581372
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.40651236
40* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39999870
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36989504
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.36884437
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.34564302
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33907511
45* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.31267921
46* LXR_22292898_ChIP-Seq_THP-1_Human1.28275036
47ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.24495015
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24133885
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.23235587
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23124441
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23116409
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22061795
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.22022551
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22015647
55* RACK7_27058665_Chip-Seq_MCF-7_Human1.21544965
56SOX2_20726797_ChIP-Seq_SW620_Human1.21369775
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20321038
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18267036
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17781669
60JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17431365
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16566086
62* KDM2B_26808549_Chip-Seq_K562_Human1.15073022
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14626175
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14626175
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.14437300
66HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14349290
67* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13308501
68* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12776362
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12758762
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11086883
71* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10644682
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10593673
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10211859
74JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09760827
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.07399337
76FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07217946
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07052008
78* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06962746
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05615420
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04922062
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04679001
82* TCF7_22412390_ChIP-Seq_EML_Mouse1.04234024
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03852336
84SA1_22415368_ChIP-Seq_MEFs_Mouse1.03621058
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01203750
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.00986993
87NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99549436
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99345372
89* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99264308
90P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98483425
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97893855
92SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97162180
93GATA1_19941826_ChIP-Seq_K562_Human0.97007055
94MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96971087
95RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96531120
96TP53_23651856_ChIP-Seq_MEFs_Mouse0.95905900
97KDM2B_26808549_Chip-Seq_DND41_Human0.95218591
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94704936
99UBF1/2_26484160_Chip-Seq_HMECs_Human0.94511358
100CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94202126
101DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93453088
102CSB_26484114_Chip-Seq_FIBROBLAST_Human0.92468776
103SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92208431
104VDR_21846776_ChIP-Seq_THP-1_Human0.91875869
105CTCF_27219007_Chip-Seq_Bcells_Human0.91827354
106TET1_21490601_ChIP-Seq_MESCs_Mouse0.91668627
107BRD4_25478319_ChIP-Seq_HGPS_Human0.91386553
108BCAT_22108803_ChIP-Seq_LS180_Human0.90744728
109GATA1_22025678_ChIP-Seq_K562_Human0.90643304
110SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89547663
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89547663
112ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89439374
113ZNF263_19887448_ChIP-Seq_K562_Human0.89319493
114RUNX1_27514584_Chip-Seq_MCF-7_Human0.88731721
115* DROSHA_22980978_ChIP-Seq_HELA_Human0.88445610
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87402967
117EGR1_19032775_ChIP-ChIP_M12_Human0.87345081
118SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87018786
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86652237
120AR_21572438_ChIP-Seq_LNCaP_Human0.86462387
121ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85707218
122* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85096737
123GATA3_24758297_ChIP-Seq_MCF-7_Human0.84048047
124ISL1_27105846_Chip-Seq_CPCs_Mouse0.83937722
125* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.82481344
126ATF3_27146783_Chip-Seq_COLON_Human0.81358416
127FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81174553
128TCF4_18268006_ChIP-ChIP_LS174T_Human0.80766776

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.16502552
2MP0002837_dystrophic_cardiac_calcinosis4.90859028
3MP0005275_abnormal_skin_tensile4.38150300
4MP0005503_abnormal_tendon_morphology3.53241639
5MP0001958_emphysema3.20565689
6MP0006054_spinal_hemorrhage3.15837335
7MP0004084_abnormal_cardiac_muscle2.89198155
8MP0003279_aneurysm2.80859456
9MP0002254_reproductive_system_inflammat2.77995263
10MP0000751_myopathy2.77659003
11MP0005670_abnormal_white_adipose2.69017406
12MP0004272_abnormal_basement_membrane2.60753530
13MP0004036_abnormal_muscle_relaxation2.46148797
14MP0003705_abnormal_hypodermis_morpholog2.15377273
15MP0000749_muscle_degeneration1.96485589
16MP0001879_abnormal_lymphatic_vessel1.90278677
17MP0003566_abnormal_cell_adhesion1.80914963
18MP0004130_abnormal_muscle_cell1.78767894
19MP0005666_abnormal_adipose_tissue1.66333969
20MP0008004_abnormal_stomach_pH1.64995922
21MP0000013_abnormal_adipose_tissue1.63820769
22MP0010368_abnormal_lymphatic_system1.62750787
23MP0004185_abnormal_adipocyte_glucose1.62551691
24MP0005330_cardiomyopathy1.61125647
25MP0004215_abnormal_myocardial_fiber1.56751105
26MP0001542_abnormal_bone_strength1.55387009
27MP0006138_congestive_heart_failure1.52054991
28MP0003567_abnormal_fetal_cardiomyocyte1.50930242
29MP0005257_abnormal_intraocular_pressure1.50061906
30MP0002060_abnormal_skin_morphology1.49288941
31MP0005623_abnormal_meninges_morphology1.47075118
32MP0005375_adipose_tissue_phenotype1.44977180
33MP0008775_abnormal_heart_ventricle1.44880676
34MP0002108_abnormal_muscle_morphology1.43071465
35MP0000767_abnormal_smooth_muscle1.40912239
36MP0000343_altered_response_to1.40294108
37MP0000750_abnormal_muscle_regeneration1.39014334
38MP0004087_abnormal_muscle_fiber1.38342410
39MP0002998_abnormal_bone_remodeling1.37576636
40MP0005385_cardiovascular_system_phenoty1.36541253
41MP0001544_abnormal_cardiovascular_syste1.36541253
42MP0005508_abnormal_skeleton_morphology1.35089661
43MP0005164_abnormal_response_to1.33978349
44MP0004484_altered_response_of1.29875407
45MP0005058_abnormal_lysosome_morphology1.29672175
46MP0004883_abnormal_blood_vessel1.29529751
47MP0000604_amyloidosis1.25994953
48MP0003191_abnormal_cellular_cholesterol1.25305487
49MP0003724_increased_susceptibility_to1.24322089
50MP0003300_gastrointestinal_ulcer1.22595097
51MP0002269_muscular_atrophy1.22049216
52MP0000003_abnormal_adipose_tissue1.20733914
53MP0009840_abnormal_foam_cell1.20401132
54MP0004510_myositis1.20141305
55MP0005620_abnormal_muscle_contractility1.19393625
56MP0000681_abnormal_thyroid_gland1.18867850
57MP0005409_darkened_coat_color1.15444578
58MP0002127_abnormal_cardiovascular_syste1.12489496
59MP0002106_abnormal_muscle_physiology1.11929596
60MP0010630_abnormal_cardiac_muscle1.11798254
61MP0005369_muscle_phenotype1.11531414
62MP0003950_abnormal_plasma_membrane1.11003694
63MP0000759_abnormal_skeletal_muscle1.08860120
64MP0002972_abnormal_cardiac_muscle1.08461429
65MP0004145_abnormal_muscle_electrophysio1.07341706
66MP0003646_muscle_fatigue1.06433359
67MP0010030_abnormal_orbit_morphology1.05714195
68MP0002877_abnormal_melanocyte_morpholog1.03491247
69MP0005023_abnormal_wound_healing1.02978010
70MP0000249_abnormal_blood_vessel1.01719104
71MP0002295_abnormal_pulmonary_circulatio0.96230726
72MP0003045_fibrosis0.95848212
73MP0001849_ear_inflammation0.93871400
74MP0000163_abnormal_cartilage_morphology0.89138508
75MP0001533_abnormal_skeleton_physiology0.88410532
76MP0002332_abnormal_exercise_endurance0.88318541
77MP0003828_pulmonary_edema0.88192738
78MP0002115_abnormal_skeleton_extremities0.87990971
79MP0002896_abnormal_bone_mineralization0.86473286
80MP0002128_abnormal_blood_circulation0.83012995
81MP0005167_abnormal_blood-brain_barrier0.81166669
82MP0003303_peritoneal_inflammation0.80135977
83MP0005165_increased_susceptibility_to0.79500001
84MP0008260_abnormal_autophagy0.76658506
85MP0009250_abnormal_appendicular_skeleto0.76618209
86MP0005390_skeleton_phenotype0.76384788
87MP0002909_abnormal_adrenal_gland0.76277475
88MP0001661_extended_life_span0.76173031
89MP0001614_abnormal_blood_vessel0.75958955
90MP0003448_altered_tumor_morphology0.75909723
91MP0002971_abnormal_brown_adipose0.75752085
92MP0000747_muscle_weakness0.75128936
93MP0003091_abnormal_cell_migration0.74624028
94MP0002933_joint_inflammation0.73616202
95MP0009115_abnormal_fat_cell0.73550919
96MP0002282_abnormal_trachea_morphology0.73502918
97MP0000858_altered_metastatic_potential0.71727736
98MP0000733_abnormal_muscle_development0.70872859
99MP0003878_abnormal_ear_physiology0.70158340
100MP0005377_hearing/vestibular/ear_phenot0.70158340
101MP0003385_abnormal_body_wall0.68596147
102MP0010329_abnormal_lipoprotein_level0.66305988
103MP0005451_abnormal_body_composition0.65368871
104MP0001299_abnormal_eye_distance/0.65111193
105MP0002925_abnormal_cardiovascular_devel0.65092052
106MP0004233_abnormal_muscle_weight0.65079102
107MP0003795_abnormal_bone_structure0.64506429
108MP0009780_abnormal_chondrocyte_physiolo0.64344376
109MP0005076_abnormal_cell_differentiation0.64199561
110MP0000465_gastrointestinal_hemorrhage0.63943651
111MP0001243_abnormal_dermal_layer0.63067542
112MP0005388_respiratory_system_phenotype0.62436005
113MP0002133_abnormal_respiratory_system0.62436005
114MP0009384_cardiac_valve_regurgitation0.62211027
115MP0005595_abnormal_vascular_smooth0.61582616
116MP0000266_abnormal_heart_morphology0.61538415
117MP0000230_abnormal_systemic_arterial0.60371189
118MP0004858_abnormal_nervous_system0.59959750

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.70122235
2Broad metatarsal (HP:0001783)5.60249320
3Systemic lupus erythematosus (HP:0002725)5.12493545
4Spondylolisthesis (HP:0003302)5.08856415
5Aortic dissection (HP:0002647)4.94512219
6Ankle contracture (HP:0006466)4.81856185
7Right ventricular cardiomyopathy (HP:0011663)4.71449830
8Cerebral aneurysm (HP:0004944)4.49812854
9Hyporeflexia of lower limbs (HP:0002600)4.44216780
10Aortic aneurysm (HP:0004942)4.09557733
11Protrusio acetabuli (HP:0003179)4.07992021
12Type 1 muscle fiber predominance (HP:0003803)3.73883880
13Delayed closure of the anterior fontanelle (HP:0001476)3.71924848
14Increased connective tissue (HP:0009025)3.64847834
15Absent frontal sinuses (HP:0002688)3.57860290
16Soft skin (HP:0000977)3.46412812
17Asymmetric septal hypertrophy (HP:0001670)3.43476326
18Arterial tortuosity (HP:0005116)3.39337123
19Osteolytic defects of the phalanges of the hand (HP:0009771)3.35711263
20Osteolytic defects of the hand bones (HP:0009699)3.35711263
21Muscle fiber splitting (HP:0003555)3.33244083
22Cervical subluxation (HP:0003308)3.26764924
23Shallow orbits (HP:0000586)3.25783656
24Vascular tortuosity (HP:0004948)3.18384717
25Fragile skin (HP:0001030)3.16945174
26Distal lower limb muscle weakness (HP:0009053)3.10775717
27Blue sclerae (HP:0000592)3.03965895
28Purpura (HP:0000979)3.02866500
29Increased variability in muscle fiber diameter (HP:0003557)3.01220021
30Ulnar bowing (HP:0003031)2.98133321
31Spinal rigidity (HP:0003306)2.97090852
32Persistence of primary teeth (HP:0006335)2.89258432
33Abnormality of the calf musculature (HP:0001430)2.87753215
34Nemaline bodies (HP:0003798)2.84367093
35Lipoatrophy (HP:0100578)2.79282353
36Pulmonary artery stenosis (HP:0004415)2.75534010
37Short hallux (HP:0010109)2.74553215
38Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.74023068
39Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.71878061
40Mitral valve prolapse (HP:0001634)2.68309222
41Muscle fiber inclusion bodies (HP:0100299)2.66730347
42Follicular hyperkeratosis (HP:0007502)2.64669851
43Abnormality of skeletal muscle fiber size (HP:0012084)2.59992364
44Limb-girdle muscle atrophy (HP:0003797)2.59594817
45Radial bowing (HP:0002986)2.57219498
46Joint stiffness (HP:0001387)2.53654639
47Enlarged penis (HP:0000040)2.52852565
48Aplasia/Hypoplasia of the hallux (HP:0008362)2.52704534
49Hyperextensible skin (HP:0000974)2.52349675
50Vertebral compression fractures (HP:0002953)2.51472568
51Wormian bones (HP:0002645)2.51320828
52Atrophic scars (HP:0001075)2.48180367
53Genu recurvatum (HP:0002816)2.46171363
54Peritonitis (HP:0002586)2.45243373
55Scapular winging (HP:0003691)2.45067854
56Abnormal delivery (HP:0001787)2.45029606
57Ectopia lentis (HP:0001083)2.43579370
58Lymphangioma (HP:0100764)2.39876244
59EMG: myopathic abnormalities (HP:0003458)2.38063623
60Striae distensae (HP:0001065)2.37388961
61Dilatation of the ascending aorta (HP:0005111)2.34512038
62Distal lower limb amyotrophy (HP:0008944)2.34369287
63Ovoid vertebral bodies (HP:0003300)2.33741064
64Aneurysm (HP:0002617)2.32721496
65Abnormality of dentin (HP:0010299)2.30368337
66Ventricular tachycardia (HP:0004756)2.27441275
67Abnormality of complement system (HP:0005339)2.27307513
68Bladder diverticulum (HP:0000015)2.26972638
69Mildly elevated creatine phosphokinase (HP:0008180)2.26791825
70Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.26474388
71Bowing of the arm (HP:0006488)2.25885569
72Bowed forearm bones (HP:0003956)2.25885569
73Hypoplasia of the iris (HP:0007676)2.24342833
74Slender build (HP:0001533)2.23585242
75Elbow flexion contracture (HP:0002987)2.22474644
76Centrally nucleated skeletal muscle fibers (HP:0003687)2.21429581
77Urinary glycosaminoglycan excretion (HP:0003541)2.21301233
78Mucopolysacchariduria (HP:0008155)2.21301233
79Distal arthrogryposis (HP:0005684)2.20333434
80Wide anterior fontanel (HP:0000260)2.19683802
81Redundant skin (HP:0001582)2.18066396
82Tarsal synostosis (HP:0008368)2.17806347
83Abnormality of the frontal sinuses (HP:0002687)2.17262996
84Mesangial abnormality (HP:0001966)2.16418761
85Delayed cranial suture closure (HP:0000270)2.14927711
86Joint laxity (HP:0001388)2.14420085
87Venous abnormality (HP:0002624)2.13279403
88Limited hip movement (HP:0008800)2.11854755
89Bronchomalacia (HP:0002780)2.11663909
90Thin ribs (HP:0000883)2.09289976
91Popliteal pterygium (HP:0009756)2.08825845
92Abnormality of polysaccharide metabolism (HP:0011012)2.08386167
93Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08386167
94Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08386167
95Bundle branch block (HP:0011710)2.08166066
96Abnormal cartilage morphology (HP:0002763)2.06895941
97Hip contracture (HP:0003273)2.06673789
98Difficulty running (HP:0009046)2.06564164
99Aortic regurgitation (HP:0001659)2.06460149
100Overgrowth (HP:0001548)2.05437123
101Ulnar deviation of the wrist (HP:0003049)2.04830660
102Coxa vara (HP:0002812)2.04005622
103Sudden death (HP:0001699)2.03523763
104Atrial fibrillation (HP:0005110)2.02921910
105Wrist flexion contracture (HP:0001239)1.99535406
106Nonimmune hydrops fetalis (HP:0001790)1.99453188
107Oligomenorrhea (HP:0000876)1.99354903
108Myopathic facies (HP:0002058)1.99346903
109Exercise-induced myalgia (HP:0003738)1.97246492
110Mitral stenosis (HP:0001718)1.96348910
111Acanthosis nigricans (HP:0000956)1.96253087
112Mitral regurgitation (HP:0001653)1.95753677
113Turricephaly (HP:0000262)1.94475040
114Venous insufficiency (HP:0005293)1.92729800
115Dysostosis multiplex (HP:0000943)1.92703043
116Rectal prolapse (HP:0002035)1.92179897
117Neck muscle weakness (HP:0000467)1.91156395
118Synostosis involving bones of the feet (HP:0009140)1.90999690
119Synostosis involving bones of the lower limbs (HP:0009138)1.90999690
120Neonatal short-limb short stature (HP:0008921)1.90909341
121Biconcave vertebral bodies (HP:0004586)1.90587793
122Facial diplegia (HP:0001349)1.90067695
123Complement deficiency (HP:0004431)1.87672409
124Upper limb amyotrophy (HP:0009129)1.87239370
125Distal upper limb amyotrophy (HP:0007149)1.87239370
126Gingival overgrowth (HP:0000212)1.86753153
127Polycythemia (HP:0001901)1.86513716
128Exercise-induced muscle cramps (HP:0003710)1.85430165
129Abnormal atrioventricular conduction (HP:0005150)1.84748488
130Thin bony cortex (HP:0002753)1.84252002
131Round ear (HP:0100830)1.84197682
132Disproportionate tall stature (HP:0001519)1.83019365
133Primary atrial arrhythmia (HP:0001692)1.82658199
134Generalized amyotrophy (HP:0003700)1.82033385
135Bulbar palsy (HP:0001283)1.81987651
136Supraventricular arrhythmia (HP:0005115)1.80959258
137Infantile muscular hypotonia (HP:0008947)1.79703360
138Aortic valve stenosis (HP:0001650)1.78435136
139Abnormality of the acetabulum (HP:0003170)1.74030908
140Gowers sign (HP:0003391)1.71788736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.49512127
2TRIB34.46319084
3TGFBR24.28098309
4MYLK3.69968883
5ERN13.51321037
6PDGFRA2.88910118
7PRPF4B2.82013965
8MUSK2.33438570
9LMTK22.26703102
10EPHB22.18728074
11PKN22.10310105
12DDR22.06656686
13MAP3K61.96987396
14DMPK1.91016913
15BMX1.84118403
16RIPK11.80628461
17SIK11.76169363
18PDK21.68588527
19MST1R1.64426539
20PHKG11.55528050
21PHKG21.55528050
22TIE11.51575574
23TAOK21.48508861
24PAK41.47436831
25CAMK1D1.37508155
26MAPKAPK31.34338899
27EPHB11.33456336
28ROCK21.24584375
29MAPK121.23842613
30TRPM71.23185112
31MET1.23008459
32FGFR21.22984148
33ROCK11.21132970
34EEF2K1.20215841
35MOS1.19874135
36FGFR41.15458057
37INSRR1.15222845
38CAMK1G1.13195300
39ILK1.13136680
40MAPK71.12713362
41FGFR11.11332013
42LATS11.09552503
43BCKDK1.08199996
44FER1.06066274
45EPHA31.05481162
46PTK61.04418206
47MAP3K71.04294860
48PDPK11.03881857
49MAP3K31.00672056
50PDK31.00610113
51PDK41.00610113
52KDR0.99228760
53NEK90.98583029
54PIK3CG0.96869509
55PAK20.96369295
56PRKD10.94647293
57MAP2K30.94155350
58PTK2B0.93902806
59MAP2K20.92998749
60PDGFRB0.92954793
61TYRO30.92224678
62PIK3CA0.88675449
63LRRK20.86037778
64OBSCN0.85849676
65RPS6KA20.84400008
66RPS6KL10.82556505
67RPS6KC10.82556505
68MAPK40.80977416
69PRKCH0.79700817
70CDC42BPA0.73344151
71MARK20.70034350
72STK380.69704685
73NME10.68643235
74MAP3K100.66845600
75PRKD30.66757144
76RPS6KA60.63690186
77KIT0.63486449
78NTRK10.63141194
79LATS20.61411909
80MAP2K10.60896026
81FGFR30.60262317
82PTK20.60216456
83NME20.60199072
84PDK10.59507923
85MAP3K10.59309173
86JAK10.59063189
87MTOR0.57159093
88RET0.54225198
89MAPK150.53015609
90DAPK30.52986149
91ICK0.52180903
92PAK30.51328287
93FLT30.51173574
94PRKAA20.50665797
95LIMK10.50072387
96HIPK20.49285054
97STK30.49148699
98ZAP700.48562376
99STK240.46735110
100IRAK30.46349662
101MAP3K130.46004869
102ABL20.44862479
103SMG10.44562089
104IGF1R0.43894059
105SRC0.43793047
106EPHA20.43668929
107CAMK2D0.42292494
108NLK0.41281333
109GSK3A0.41247439
110TYK20.40500864
111FES0.40404926
112MAP3K110.40177402
113TBK10.38568025
114PRKD20.38542155
115KSR20.37067151
116STK38L0.35490679
117PRKG20.34348908
118INSR0.33983548
119CAMK2G0.33352854
120BRAF0.32963923
121PINK10.32747959
122JAK30.32448362
123CLK10.32066876
124TESK10.31634725
125PRKCE0.31543507
126CSK0.30726323
127TGFBR10.30238245
128AKT20.30026137

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.84936488
2ECM-receptor interaction_Homo sapiens_hsa045123.18088203
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.62427298
4Dilated cardiomyopathy_Homo sapiens_hsa054142.59957196
5Complement and coagulation cascades_Homo sapiens_hsa046102.26099303
6Caffeine metabolism_Homo sapiens_hsa002322.25388137
7PPAR signaling pathway_Homo sapiens_hsa033202.22882518
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.20040517
9Focal adhesion_Homo sapiens_hsa045102.02416442
10Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.89349048
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80564133
12Staphylococcus aureus infection_Homo sapiens_hsa051501.78188240
13Lysosome_Homo sapiens_hsa041421.70093431
14Amoebiasis_Homo sapiens_hsa051461.60143912
15Arachidonic acid metabolism_Homo sapiens_hsa005901.58695076
16Protein digestion and absorption_Homo sapiens_hsa049741.53300778
17Fatty acid degradation_Homo sapiens_hsa000711.50225372
18Propanoate metabolism_Homo sapiens_hsa006401.48226000
19Proteoglycans in cancer_Homo sapiens_hsa052051.44702385
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44484651
21Notch signaling pathway_Homo sapiens_hsa043301.44215013
22Nitrogen metabolism_Homo sapiens_hsa009101.43894174
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.39842620
24Fatty acid metabolism_Homo sapiens_hsa012121.38181901
25Other glycan degradation_Homo sapiens_hsa005111.35135166
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34345436
27Viral myocarditis_Homo sapiens_hsa054161.28350914
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26376128
29TGF-beta signaling pathway_Homo sapiens_hsa043501.14989551
30Adipocytokine signaling pathway_Homo sapiens_hsa049201.12392865
31Vascular smooth muscle contraction_Homo sapiens_hsa042701.11908009
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11417270
33Glutathione metabolism_Homo sapiens_hsa004801.06254110
34Bladder cancer_Homo sapiens_hsa052191.03199129
35PI3K-Akt signaling pathway_Homo sapiens_hsa041511.02968274
36Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99029650
37Pertussis_Homo sapiens_hsa051330.98137050
38Fatty acid biosynthesis_Homo sapiens_hsa000610.97393027
39Thyroid hormone synthesis_Homo sapiens_hsa049180.97119803
40Insulin resistance_Homo sapiens_hsa049310.95931519
41Sphingolipid metabolism_Homo sapiens_hsa006000.92504633
42Fat digestion and absorption_Homo sapiens_hsa049750.91805478
43Osteoclast differentiation_Homo sapiens_hsa043800.89533658
44Starch and sucrose metabolism_Homo sapiens_hsa005000.89000875
45Adherens junction_Homo sapiens_hsa045200.86396757
46TNF signaling pathway_Homo sapiens_hsa046680.83668582
47Glycerolipid metabolism_Homo sapiens_hsa005610.83273292
48GnRH signaling pathway_Homo sapiens_hsa049120.83128264
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82242775
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80248982
51Tight junction_Homo sapiens_hsa045300.80165462
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79760911
53Ras signaling pathway_Homo sapiens_hsa040140.79331533
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78141084
55Tryptophan metabolism_Homo sapiens_hsa003800.77748308
56Small cell lung cancer_Homo sapiens_hsa052220.76904143
57Chronic myeloid leukemia_Homo sapiens_hsa052200.76447423
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76138844
59Cardiac muscle contraction_Homo sapiens_hsa042600.73438748
60Toxoplasmosis_Homo sapiens_hsa051450.73286213
61HIF-1 signaling pathway_Homo sapiens_hsa040660.73034343
62Prion diseases_Homo sapiens_hsa050200.72508268
63AMPK signaling pathway_Homo sapiens_hsa041520.72167839
64Malaria_Homo sapiens_hsa051440.71298768
65Carbon metabolism_Homo sapiens_hsa012000.71032831
66Phenylalanine metabolism_Homo sapiens_hsa003600.70134926
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.69815248
68Insulin signaling pathway_Homo sapiens_hsa049100.69730647
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69575344
70Histidine metabolism_Homo sapiens_hsa003400.66981422
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64898677
72Circadian rhythm_Homo sapiens_hsa047100.64522964
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64414072
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64227351
75Pyruvate metabolism_Homo sapiens_hsa006200.63686419
76Acute myeloid leukemia_Homo sapiens_hsa052210.63442341
77Phagosome_Homo sapiens_hsa041450.62504393
78Estrogen signaling pathway_Homo sapiens_hsa049150.60800853
79Rap1 signaling pathway_Homo sapiens_hsa040150.60354769
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60191451
81Lysine degradation_Homo sapiens_hsa003100.58785368
82Renin secretion_Homo sapiens_hsa049240.58585085
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57810829
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56717904
85Arginine and proline metabolism_Homo sapiens_hsa003300.53947957
86Linoleic acid metabolism_Homo sapiens_hsa005910.53516793
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52603007
88VEGF signaling pathway_Homo sapiens_hsa043700.51992483
89Renin-angiotensin system_Homo sapiens_hsa046140.51838872
90Galactose metabolism_Homo sapiens_hsa000520.51612313
91Renal cell carcinoma_Homo sapiens_hsa052110.51601594
92Tuberculosis_Homo sapiens_hsa051520.51407765
93Rheumatoid arthritis_Homo sapiens_hsa053230.51371663
94Dorso-ventral axis formation_Homo sapiens_hsa043200.51109702
95Oxytocin signaling pathway_Homo sapiens_hsa049210.50536650
96Glioma_Homo sapiens_hsa052140.50128714
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49831570
98Fructose and mannose metabolism_Homo sapiens_hsa000510.48652515
99MicroRNAs in cancer_Homo sapiens_hsa052060.48614250
100Melanogenesis_Homo sapiens_hsa049160.48401427
101Mineral absorption_Homo sapiens_hsa049780.48056638
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.47844130
103Pentose phosphate pathway_Homo sapiens_hsa000300.46942151
104Platelet activation_Homo sapiens_hsa046110.46882290
105Salmonella infection_Homo sapiens_hsa051320.46615209
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.46507920
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46445383
108MAPK signaling pathway_Homo sapiens_hsa040100.46155112
109Pathways in cancer_Homo sapiens_hsa052000.45740688
110Endocytosis_Homo sapiens_hsa041440.44710497
111Arginine biosynthesis_Homo sapiens_hsa002200.44565573
112beta-Alanine metabolism_Homo sapiens_hsa004100.44554281
113mTOR signaling pathway_Homo sapiens_hsa041500.43900776
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.42639348
115Sulfur metabolism_Homo sapiens_hsa009200.42477815
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42300742
117Pancreatic cancer_Homo sapiens_hsa052120.41860679
118Glucagon signaling pathway_Homo sapiens_hsa049220.41666017
119Apoptosis_Homo sapiens_hsa042100.40930539
120Prolactin signaling pathway_Homo sapiens_hsa049170.40802748
121Leishmaniasis_Homo sapiens_hsa051400.40132525
122HTLV-I infection_Homo sapiens_hsa051660.40008929
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39528895
124Prostate cancer_Homo sapiens_hsa052150.39482632
125cAMP signaling pathway_Homo sapiens_hsa040240.39383544
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.39166870
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39039977
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.38485354
129Sulfur relay system_Homo sapiens_hsa041220.38102557
130Melanoma_Homo sapiens_hsa052180.34519246
131Ovarian steroidogenesis_Homo sapiens_hsa049130.32909306
132Hippo signaling pathway_Homo sapiens_hsa043900.32743771
133FoxO signaling pathway_Homo sapiens_hsa040680.32139493
134Gap junction_Homo sapiens_hsa045400.32060395
135Basal cell carcinoma_Homo sapiens_hsa052170.31852293
136Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31029094

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