HTT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.96706653
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.91525285
3synaptic vesicle maturation (GO:0016188)4.69461765
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.53412878
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.07701788
6sodium ion export (GO:0071436)3.97851625
7regulation of ARF protein signal transduction (GO:0032012)3.97530192
8cerebellar Purkinje cell differentiation (GO:0021702)3.94848645
9histone H3-K36 demethylation (GO:0070544)3.86399953
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.84039798
11cellular potassium ion homeostasis (GO:0030007)3.82088391
12negative regulation of erythrocyte differentiation (GO:0045647)3.73390304
13ionotropic glutamate receptor signaling pathway (GO:0035235)3.72929740
14regulation of glutamate receptor signaling pathway (GO:1900449)3.72398403
15vocalization behavior (GO:0071625)3.70334292
16layer formation in cerebral cortex (GO:0021819)3.59876972
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.59375826
18adherens junction assembly (GO:0034333)3.57002367
19glutamate secretion (GO:0014047)3.52107777
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.48145261
21cell-substrate adherens junction assembly (GO:0007045)3.47941293
22focal adhesion assembly (GO:0048041)3.47941293
23protein localization to endosome (GO:0036010)3.46901102
24mannose metabolic process (GO:0006013)3.44732190
25proline transport (GO:0015824)3.44354452
26negative regulation of cell killing (GO:0031342)3.41625254
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.41625254
28regulation of synaptic vesicle exocytosis (GO:2000300)3.35884058
29establishment of nucleus localization (GO:0040023)3.34260933
30regulation of histone H3-K27 methylation (GO:0061085)3.29079372
31synaptic vesicle exocytosis (GO:0016079)3.28087802
32regulation of clathrin-mediated endocytosis (GO:2000369)3.26712043
33exploration behavior (GO:0035640)3.24428999
34synaptic vesicle endocytosis (GO:0048488)3.23771093
35gamma-aminobutyric acid transport (GO:0015812)3.22253398
36protein localization to synapse (GO:0035418)3.19365418
37nuclear pore complex assembly (GO:0051292)3.16265923
38cytoplasmic mRNA processing body assembly (GO:0033962)3.15870918
39glutamate receptor signaling pathway (GO:0007215)3.13872415
40pre-miRNA processing (GO:0031054)3.11887741
41histone H3-K4 trimethylation (GO:0080182)3.09427114
42regulation of nucleobase-containing compound transport (GO:0032239)3.08419567
43neurotransmitter secretion (GO:0007269)3.06372977
44cell-substrate junction assembly (GO:0007044)3.04884940
45regulation of neuronal synaptic plasticity (GO:0048168)3.04693153
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03034068
47regulation of long-term neuronal synaptic plasticity (GO:0048169)3.02800052
48synaptic transmission, glutamatergic (GO:0035249)3.02780491
49embryonic process involved in female pregnancy (GO:0060136)3.01783629
50regulation of RNA export from nucleus (GO:0046831)3.01361165
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.00707567
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.00532789
53negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.00415529
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.00080098
55neurotransmitter-gated ion channel clustering (GO:0072578)2.99967816
56insulin-like growth factor receptor signaling pathway (GO:0048009)2.98960320
57dendrite morphogenesis (GO:0048813)2.97175102
58activation of Rac GTPase activity (GO:0032863)2.95889574
59glucocorticoid receptor signaling pathway (GO:0042921)2.95404711
60long-term memory (GO:0007616)2.95357465
61neuromuscular process controlling balance (GO:0050885)2.94586600
62regulation of synaptic vesicle transport (GO:1902803)2.93851954
63nerve growth factor signaling pathway (GO:0038180)2.92299774
64activation of protein kinase A activity (GO:0034199)2.91279897
65regulation of synapse structural plasticity (GO:0051823)2.89399030
66regulation of ARF GTPase activity (GO:0032312)2.88748079
67regulation of NFAT protein import into nucleus (GO:0051532)2.88197904
68regulation of postsynaptic membrane potential (GO:0060078)2.85956853
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.85623289
70response to muramyl dipeptide (GO:0032495)2.84294460
71membrane depolarization during action potential (GO:0086010)2.82609171
72histone lysine demethylation (GO:0070076)2.81139106
73corticosteroid receptor signaling pathway (GO:0031958)2.79734804
74cortical actin cytoskeleton organization (GO:0030866)2.79408286
75regulation of early endosome to late endosome transport (GO:2000641)2.79267756
76epithelial cell differentiation involved in prostate gland development (GO:0060742)2.78342596
77potassium ion import (GO:0010107)2.75969436
78regulation of cholesterol homeostasis (GO:2000188)2.74452789
79Golgi to endosome transport (GO:0006895)2.73872015
80cytoskeletal anchoring at plasma membrane (GO:0007016)2.73768918
81dendritic spine morphogenesis (GO:0060997)2.73247674
82cell communication by electrical coupling (GO:0010644)2.73102214
83pinocytosis (GO:0006907)2.71484238
84prepulse inhibition (GO:0060134)2.68557712
85semaphorin-plexin signaling pathway (GO:0071526)2.67917663
86response to laminar fluid shear stress (GO:0034616)2.67782552
87peptidyl-threonine phosphorylation (GO:0018107)2.67752100
88B cell receptor signaling pathway (GO:0050853)2.66274072
89positive regulation of fibroblast migration (GO:0010763)2.65475704
90positive regulation of membrane potential (GO:0045838)2.64990729
91positive regulation of synapse maturation (GO:0090129)2.64483655
92regulation of dendritic spine morphogenesis (GO:0061001)2.64097969
93clathrin coat assembly (GO:0048268)2.63529539
94G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.63030220
95alanine transport (GO:0032328)2.62845539
96histone demethylation (GO:0016577)2.61717848
97Golgi transport vesicle coating (GO:0048200)2.61237615
98COPI coating of Golgi vesicle (GO:0048205)2.61237615
99neuron-neuron synaptic transmission (GO:0007270)2.60902601
100positive regulation of gamma-delta T cell activation (GO:0046645)2.59995592
101glycine transport (GO:0015816)2.59927586
102negative regulation of histone methylation (GO:0031061)2.59518885
103embryonic camera-type eye morphogenesis (GO:0048596)2.59478347
104stress fiber assembly (GO:0043149)2.59025464
105positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.58638508
106cellular sodium ion homeostasis (GO:0006883)2.57217590
107NLS-bearing protein import into nucleus (GO:0006607)2.56983203
108stress granule assembly (GO:0034063)2.54979587
109thymic T cell selection (GO:0045061)2.54678464
110regulation of synaptic transmission, glutamatergic (GO:0051966)2.53292992
111positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.52671169
112retrograde transport, vesicle recycling within Golgi (GO:0000301)2.51865704
113membrane depolarization (GO:0051899)2.49614106
114peptidyl-threonine modification (GO:0018210)2.48297060
115response to auditory stimulus (GO:0010996)2.47742372
116surfactant homeostasis (GO:0043129)2.47471677
117establishment of protein localization to Golgi (GO:0072600)2.47415225
118peptidyl-lysine dimethylation (GO:0018027)2.46902782
119negative regulation of myotube differentiation (GO:0010832)2.46321942
120phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.46229820
121positive thymic T cell selection (GO:0045059)2.45437763
122histone H3-K4 methylation (GO:0051568)2.45010312
123regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.44342724
124regulation of glucose import in response to insulin stimulus (GO:2001273)2.44292100
125G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44137450
126activation of JUN kinase activity (GO:0007257)2.43534043
127barbed-end actin filament capping (GO:0051016)2.43396273
128intracellular estrogen receptor signaling pathway (GO:0030520)2.43053940
129positive regulation of dendritic spine morphogenesis (GO:0061003)2.42776146
130cortical cytoskeleton organization (GO:0030865)2.41864078
131positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.41218334
132positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.39482284
133negative regulation of fatty acid transport (GO:2000192)2.39403657
134regulation of neurotransmitter secretion (GO:0046928)2.39214402
135* vesicle transport along microtubule (GO:0047496)2.38658993
136spliceosomal tri-snRNP complex assembly (GO:0000244)2.38583018
137* regulation of synaptic plasticity (GO:0048167)2.38258720
138membrane hyperpolarization (GO:0060081)2.37412729
139protein targeting to Golgi (GO:0000042)2.37031175
140regulation of Rac protein signal transduction (GO:0035020)2.34405092
141nuclear pore organization (GO:0006999)2.33761599
142modulation by symbiont of host cellular process (GO:0044068)2.33622607
143regulation of Rap GTPase activity (GO:0032317)2.33383889
144long-term synaptic potentiation (GO:0060291)2.32924898
145chemosensory behavior (GO:0007635)2.32559130
146neuronal action potential propagation (GO:0019227)2.31154247
147regulation of mammary gland epithelial cell proliferation (GO:0033599)2.30970046
148negative regulation of cell size (GO:0045792)2.29944072
149positive regulation of Rac GTPase activity (GO:0032855)2.29630467
150neurotransmitter transport (GO:0006836)2.29126251
151innervation (GO:0060384)2.28289239
152potassium ion homeostasis (GO:0055075)2.28169970
153embryonic eye morphogenesis (GO:0048048)2.27985558
154histone H3-K9 demethylation (GO:0033169)2.27935981
155positive regulation of Rap GTPase activity (GO:0032854)2.27815814
156positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.27079883
157positive regulation of receptor recycling (GO:0001921)2.25867521
158pore complex assembly (GO:0046931)2.25571153
159cellular response to epidermal growth factor stimulus (GO:0071364)2.24716688
160receptor catabolic process (GO:0032801)2.22862670
1613-UTR-mediated mRNA stabilization (GO:0070935)2.22042556
162regulation of gamma-delta T cell activation (GO:0046643)2.20882474
163regulation of lipid kinase activity (GO:0043550)2.19269968
164protein dealkylation (GO:0008214)2.17990816
165protein demethylation (GO:0006482)2.17990816
166activation of MAPKKK activity (GO:0000185)2.17519784
167response to epidermal growth factor (GO:0070849)2.17024776
168signal complex assembly (GO:0007172)2.14021737
169mRNA stabilization (GO:0048255)2.13920538
170RNA stabilization (GO:0043489)2.13920538
171germinal center formation (GO:0002467)2.13822772
172apoptotic process involved in morphogenesis (GO:0060561)2.13372533
173negative regulation of toll-like receptor signaling pathway (GO:0034122)2.12160651
174regulation of gamma-delta T cell differentiation (GO:0045586)2.11037583
175hypotonic response (GO:0006971)2.10674221
176positive regulation of Cdc42 GTPase activity (GO:0043089)2.10121029
177B cell homeostasis (GO:0001782)2.09816181
178peptidyl-serine phosphorylation (GO:0018105)2.09762908
179regulation of B cell receptor signaling pathway (GO:0050855)2.08343857
180epithelial cell-cell adhesion (GO:0090136)2.06357394
181modulation by symbiont of host defense response (GO:0052031)2.06343302
182modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.06343302
183positive regulation by organism of defense response of other organism involved in symbiotic interact2.06343302
184modulation by symbiont of host immune response (GO:0052553)2.06343302

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.49843881
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.87590539
3DROSHA_22980978_ChIP-Seq_HELA_Human2.77309662
4VDR_21846776_ChIP-Seq_THP-1_Human2.69438093
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.62522949
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.54790615
7GBX2_23144817_ChIP-Seq_PC3_Human2.47313564
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.38719402
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34425018
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.24588208
11LXR_22292898_ChIP-Seq_THP-1_Human2.20999866
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19119311
13* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09831014
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.07345630
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.06020644
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04557180
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98470816
18* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96633452
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.94254239
20REST_21632747_ChIP-Seq_MESCs_Mouse1.86738574
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81081935
22RACK7_27058665_Chip-Seq_MCF-7_Human1.79325051
23* VDR_24763502_ChIP-Seq_THP-1_Human1.67556219
24TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.67080489
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64399441
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64027241
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61656068
28CLOCK_20551151_ChIP-Seq_293T_Human1.60561955
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59527487
30MAF_26560356_Chip-Seq_TH1_Human1.59329104
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58779831
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.57897653
33TP53_16413492_ChIP-PET_HCT116_Human1.57332385
34AR_21572438_ChIP-Seq_LNCaP_Human1.56332820
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55854693
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55156594
37KDM2B_26808549_Chip-Seq_K562_Human1.55002181
38* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.54787748
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54053199
40* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53551025
41SCL_19346495_ChIP-Seq_HPC-7_Human1.52379406
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.51817399
43DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.51174979
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51141336
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51092735
46E2F7_22180533_ChIP-Seq_HELA_Human1.50908201
47* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50024108
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49710273
49* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49125119
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48454455
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48454455
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48075920
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47972968
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47445638
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45763154
56* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43918638
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.43691368
58SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43457068
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43149402
60* SMAD4_21799915_ChIP-Seq_A2780_Human1.41834166
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41247389
62KDM2B_26808549_Chip-Seq_DND41_Human1.40513091
63* STAT3_23295773_ChIP-Seq_U87_Human1.40005961
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39952348
65GATA1_22025678_ChIP-Seq_K562_Human1.39140847
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39059011
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38697506
68AR_19668381_ChIP-Seq_PC3_Human1.37707310
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35916505
70* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35056233
71FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34996999
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34726065
73AHR_22903824_ChIP-Seq_MCF-7_Human1.34532608
74RUNX1_27514584_Chip-Seq_MCF-7_Human1.33475682
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33228790
76REST_18959480_ChIP-ChIP_MESCs_Mouse1.32604134
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.32276582
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31607485
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31598664
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31572429
81* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31000873
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30575502
83SPI1_23127762_ChIP-Seq_K562_Human1.30478076
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.29821389
85EGR1_19374776_ChIP-ChIP_THP-1_Human1.29667044
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.29289837
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.28818081
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28804642
89EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26746709
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.25603578
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25527484
92RUNX_20019798_ChIP-Seq_JUKART_Human1.25214951
93UTX_26944678_Chip-Seq_JUKART_Human1.24588811
94TCF7_22412390_ChIP-Seq_EML_Mouse1.24080141
95* TCF4_23295773_ChIP-Seq_U87_Human1.23156051
96ZNF263_19887448_ChIP-Seq_K562_Human1.23105070
97SMC4_20622854_ChIP-Seq_HELA_Human1.22893514
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19563021
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18313863
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17949376
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17303938
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17295326
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16801022
104SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16318343
105GATA1_19941826_ChIP-Seq_K562_Human1.15227213
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14369705
107CREB1_26743006_Chip-Seq_LNCaP_Human1.13644055
108MAF_26560356_Chip-Seq_TH2_Human1.12779310
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11226884
110TBX20_22328084_ChIP-Seq_HEART_Mouse1.10757072
111TBX20_22080862_ChIP-Seq_HEART_Mouse1.10757072
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10593849
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10503361
114SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10402639
115NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09772807
116IRF8_27001747_Chip-Seq_BMDM_Mouse1.09738317
117RXR_22108803_ChIP-Seq_LS180_Human1.09549866
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09428886
119FOXM1_23109430_ChIP-Seq_U2OS_Human1.09272465
120NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09264257
121CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09241358
122UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09221341
123NCOR1_26117541_ChIP-Seq_K562_Human1.08245254
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07916300
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07360828
126SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07240220
127ESR1_20079471_ChIP-ChIP_T-47D_Human1.06796830
128SALL1_21062744_ChIP-ChIP_HESCs_Human1.06634127
129GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05312381
130NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03885385
131EZH2_27294783_Chip-Seq_ESCs_Mouse1.03609295
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02258731
133PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01552427
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00406427
135STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00331453
136SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00030772
137SMAD3_21741376_ChIP-Seq_ESCs_Human1.00007100
138UBF1/2_26484160_Chip-Seq_HMECs_Human0.99825872
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99516220
140ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99329793
141PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98621836
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96964861
143CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96661528
144IRF8_22096565_ChIP-ChIP_GC-B_Human0.96245495
145NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96114047
146TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95884168
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95185584
148AR_25329375_ChIP-Seq_VCAP_Human0.95006516
149TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94823726
150POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94823726
151* FOXA2_19822575_ChIP-Seq_HepG2_Human0.94768718
152SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94512542
153FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94500406
154FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94251038
155TCF4_18268006_ChIP-ChIP_LS174T_Human0.92961858
156* SMAD3_21741376_ChIP-Seq_EPCs_Human0.92005212
157Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91193156
158* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89785042
159RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89080969
160MYC_22102868_ChIP-Seq_BL_Human0.88659425
161DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87713403
162* SMAD3_21741376_ChIP-Seq_HESCs_Human0.86575854
163EZH2_27304074_Chip-Seq_ESCs_Mouse0.84826959
164PIAS1_25552417_ChIP-Seq_VCAP_Human0.84462283
165EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83858185
166SMAD4_21741376_ChIP-Seq_HESCs_Human0.83444154

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.55233562
2MP0004859_abnormal_synaptic_plasticity6.41031442
3MP0003635_abnormal_synaptic_transmissio3.42565779
4MP0009046_muscle_twitch3.04328775
5MP0005409_darkened_coat_color2.93053190
6MP0005451_abnormal_body_composition2.68786721
7MP0005423_abnormal_somatic_nervous2.67630310
8MP0009745_abnormal_behavioral_response2.65487509
9MP0004270_analgesia2.64949153
10* MP0002063_abnormal_learning/memory/cond2.62513289
11MP0003566_abnormal_cell_adhesion2.54764478
12MP0003787_abnormal_imprinting2.45045240
13* MP0002064_seizures2.44267320
14MP0005058_abnormal_lysosome_morphology2.39577615
15MP0003172_abnormal_lysosome_physiology2.34547605
16MP0009780_abnormal_chondrocyte_physiolo2.28727135
17MP0003880_abnormal_central_pattern2.22726100
18MP0001849_ear_inflammation2.22198414
19MP0008961_abnormal_basal_metabolism2.21808978
20MP0002877_abnormal_melanocyte_morpholog2.20728205
21MP0002822_catalepsy2.18972331
22MP0008260_abnormal_autophagy2.13768595
23MP0008569_lethality_at_weaning2.06230606
24MP0001486_abnormal_startle_reflex2.05883171
25MP0003300_gastrointestinal_ulcer2.03522919
26* MP0002572_abnormal_emotion/affect_behav2.02981448
27MP0003045_fibrosis1.93314916
28MP0001968_abnormal_touch/_nociception1.88867696
29MP0003453_abnormal_keratinocyte_physiol1.88423748
30MP0004858_abnormal_nervous_system1.86043924
31MP0003763_abnormal_thymus_physiology1.85019021
32MP0005076_abnormal_cell_differentiation1.83608192
33MP0001501_abnormal_sleep_pattern1.81844133
34MP0004510_myositis1.80516037
35MP0008057_abnormal_DNA_replication1.79711014
36MP0004185_abnormal_adipocyte_glucose1.76073720
37* MP0004811_abnormal_neuron_physiology1.69508427
38MP0004947_skin_inflammation1.67902311
39MP0002734_abnormal_mechanical_nocicepti1.67812117
40MP0002009_preneoplasia1.67195829
41MP0003303_peritoneal_inflammation1.65810950
42MP0002272_abnormal_nervous_system1.63882210
43MP0002909_abnormal_adrenal_gland1.62303524
44MP0002396_abnormal_hematopoietic_system1.59687292
45MP0001348_abnormal_lacrimal_gland1.57772913
46MP0002735_abnormal_chemical_nociception1.50796198
47* MP0002067_abnormal_sensory_capabilities1.50498091
48MP0004264_abnormal_extraembryonic_tissu1.49559075
49MP0010307_abnormal_tumor_latency1.49431156
50MP0003436_decreased_susceptibility_to1.41867400
51MP0005257_abnormal_intraocular_pressure1.39147459
52MP0009672_abnormal_birth_weight1.38579107
53MP0002998_abnormal_bone_remodeling1.38254653
54MP0003690_abnormal_glial_cell1.38130904
55MP0001915_intracranial_hemorrhage1.36515708
56MP0005666_abnormal_adipose_tissue1.36093185
57MP0003183_abnormal_peptide_metabolism1.33871137
58MP0010234_abnormal_vibrissa_follicle1.32268538
59MP0004885_abnormal_endolymph1.31706508
60MP0003191_abnormal_cellular_cholesterol1.31694285
61* MP0003633_abnormal_nervous_system1.30273364
62MP0009840_abnormal_foam_cell1.28902813
63MP0002733_abnormal_thermal_nociception1.28416376
64MP0000015_abnormal_ear_pigmentation1.27382792
65MP0000685_abnormal_immune_system1.26716535
66MP0005464_abnormal_platelet_physiology1.26023859
67* MP0005621_abnormal_cell_physiology1.25597009
68MP0005174_abnormal_tail_pigmentation1.24914254
69MP0004381_abnormal_hair_follicle1.24177193
70MP0002184_abnormal_innervation1.22927111
71MP0000955_abnormal_spinal_cord1.21840451
72MP0002796_impaired_skin_barrier1.19198280
73MP0001970_abnormal_pain_threshold1.18716668
74MP0003283_abnormal_digestive_organ1.16906735
75* MP0004924_abnormal_behavior1.16790640
76* MP0005386_behavior/neurological_phenoty1.16790640
77MP0005375_adipose_tissue_phenotype1.15881412
78* MP0003631_nervous_system_phenotype1.14436016
79MP0009278_abnormal_bone_marrow1.14418214
80MP0000371_diluted_coat_color1.13884582
81MP0003632_abnormal_nervous_system1.13862094
82MP0000003_abnormal_adipose_tissue1.13087087
83* MP0002557_abnormal_social/conspecific_i1.11068870
84MP0005646_abnormal_pituitary_gland1.10537729
85MP0001851_eye_inflammation1.09579285
86MP0001835_abnormal_antigen_presentation1.08293496
87MP0002736_abnormal_nociception_after1.05693254
88MP0000858_altered_metastatic_potential1.05655892
89MP0003091_abnormal_cell_migration1.04881834
90MP0001177_atelectasis1.03653596
91* MP0000778_abnormal_nervous_system1.03454664
92* MP0002882_abnormal_neuron_morphology1.02872024
93MP0001790_abnormal_immune_system1.02671710
94MP0005387_immune_system_phenotype1.02671710
95MP0003879_abnormal_hair_cell1.02587413
96MP0002398_abnormal_bone_marrow1.01923839
97* MP0001730_embryonic_growth_arrest1.01844218
98MP0005645_abnormal_hypothalamus_physiol1.01483349
99MP0001984_abnormal_olfaction1.01418200
100MP0002166_altered_tumor_susceptibility0.98260833
101* MP0002152_abnormal_brain_morphology0.98025362
102MP0000604_amyloidosis0.97903638
103MP0001800_abnormal_humoral_immune0.97749762
104MP0010630_abnormal_cardiac_muscle0.97191654
105* MP0002066_abnormal_motor_capabilities/c0.96927857
106MP0003329_amyloid_beta_deposits0.96638182
107* MP0001440_abnormal_grooming_behavior0.95863556
108MP0003828_pulmonary_edema0.95373265
109MP0003121_genomic_imprinting0.94032974
110MP0005000_abnormal_immune_tolerance0.91468916
111MP0000767_abnormal_smooth_muscle0.90723691
112MP0005023_abnormal_wound_healing0.90213551
113MP0003984_embryonic_growth_retardation0.89595496
114MP0000703_abnormal_thymus_morphology0.89559143
115MP0005167_abnormal_blood-brain_barrier0.88559808
116MP0010352_gastrointestinal_tract_polyps0.86782490
117* MP0002086_abnormal_extraembryonic_tissu0.85800765
118MP0005397_hematopoietic_system_phenotyp0.84922852
119MP0001545_abnormal_hematopoietic_system0.84922852
120MP0002006_tumorigenesis0.83789728
121MP0008877_abnormal_DNA_methylation0.83489979
122MP0002419_abnormal_innate_immunity0.83254464
123MP0002088_abnormal_embryonic_growth/wei0.83102379
124MP0003075_altered_response_to0.83008137
125MP0001958_emphysema0.82754803
126MP0001502_abnormal_circadian_rhythm0.82728000
127MP0009115_abnormal_fat_cell0.81574706
128MP0002452_abnormal_antigen_presenting0.81364127
129MP0004087_abnormal_muscle_fiber0.80584542
130MP0001299_abnormal_eye_distance/0.77263726
131MP0004782_abnormal_surfactant_physiolog0.77172356
132MP0008874_decreased_physiological_sensi0.77004491
133MP0002089_abnormal_postnatal_growth/wei0.76809505
134MP0000716_abnormal_immune_system0.76628676
135* MP0000350_abnormal_cell_proliferation0.76119464
136MP0000920_abnormal_myelination0.75453910
137* MP0005384_cellular_phenotype0.75312027
138MP0003279_aneurysm0.75233383
139MP0002420_abnormal_adaptive_immunity0.75169689
140MP0003115_abnormal_respiratory_system0.74819641
141* MP0002229_neurodegeneration0.74570230
142MP0000759_abnormal_skeletal_muscle0.74278541
143MP0002896_abnormal_bone_mineralization0.73978729
144MP0001819_abnormal_immune_cell0.73750340
145MP0004130_abnormal_muscle_cell0.73620729
146MP0008438_abnormal_cutaneous_collagen0.73379887
147* MP0003634_abnormal_glial_cell0.72546506
148MP0000747_muscle_weakness0.72535660
149* MP0001672_abnormal_embryogenesis/_devel0.71867102
150* MP0005380_embryogenesis_phenotype0.71867102
151MP0003705_abnormal_hypodermis_morpholog0.70032359
152MP0005551_abnormal_eye_electrophysiolog0.69879792
153MP0005310_abnormal_salivary_gland0.69334390
154MP0003122_maternal_imprinting0.68169019
155MP0004808_abnormal_hematopoietic_stem0.65207578
156MP0008770_decreased_survivor_rate0.64958400
157MP0002090_abnormal_vision0.62228704
158* MP0010769_abnormal_survival0.61269796
159MP0002069_abnormal_eating/drinking_beha0.60648604
160MP0003866_abnormal_defecation0.60582727
161MP0005623_abnormal_meninges_morphology0.59677371
162MP0002928_abnormal_bile_duct0.59494498
163MP0004742_abnormal_vestibular_system0.59418111
164MP0004233_abnormal_muscle_weight0.57132366
165MP0000733_abnormal_muscle_development0.56808768
166* MP0010768_mortality/aging0.56623616
167* MP0010770_preweaning_lethality0.56300115
168* MP0002082_postnatal_lethality0.56300115
169MP0009703_decreased_birth_body0.55231292
170MP0002075_abnormal_coat/hair_pigmentati0.53272231

Predicted human phenotypes

RankGene SetZ-score
1Focal seizures (HP:0007359)3.69680322
2Focal motor seizures (HP:0011153)3.59194742
3Macroorchidism (HP:0000053)3.44918091
4Action tremor (HP:0002345)3.12044487
5Dysmetric saccades (HP:0000641)3.04960426
6Myokymia (HP:0002411)3.03338947
7Febrile seizures (HP:0002373)3.00046849
8Abnormality of the fingertips (HP:0001211)2.97227366
9Progressive cerebellar ataxia (HP:0002073)2.89042176
10Urinary bladder sphincter dysfunction (HP:0002839)2.79657156
11Visual hallucinations (HP:0002367)2.79383031
12Impaired smooth pursuit (HP:0007772)2.76496978
13Obstructive sleep apnea (HP:0002870)2.74401778
14Broad face (HP:0000283)2.67369975
15Genetic anticipation (HP:0003743)2.67270280
16Absent frontal sinuses (HP:0002688)2.66492247
17Hyperacusis (HP:0010780)2.65636080
18Abnormality of the lower motor neuron (HP:0002366)2.65026449
19Hemiplegia (HP:0002301)2.64230195
20Gaze-evoked nystagmus (HP:0000640)2.63765629
21Colitis (HP:0002583)2.59501137
22Epileptic encephalopathy (HP:0200134)2.57904055
23Flat acetabular roof (HP:0003180)2.54919467
24Pointed chin (HP:0000307)2.54046145
25Abnormality of ocular smooth pursuit (HP:0000617)2.53838443
26Heterotopia (HP:0002282)2.52152209
27Postural instability (HP:0002172)2.49112027
28Truncal ataxia (HP:0002078)2.43447998
29Impaired vibration sensation in the lower limbs (HP:0002166)2.42278956
30Elfin facies (HP:0004428)2.36858028
31Supranuclear gaze palsy (HP:0000605)2.36079313
32Lower limb amyotrophy (HP:0007210)2.34698566
33Abnormal social behavior (HP:0012433)2.31695403
34Impaired social interactions (HP:0000735)2.31695403
35Narrow palate (HP:0000189)2.31665326
36Papilledema (HP:0001085)2.31282634
37Urinary urgency (HP:0000012)2.30768268
38Aqueductal stenosis (HP:0002410)2.30391800
39Cerebral aneurysm (HP:0004944)2.25830186
40Cerebral inclusion bodies (HP:0100314)2.23598262
41Drooling (HP:0002307)2.20851683
42Excessive salivation (HP:0003781)2.20851683
43Insomnia (HP:0100785)2.19780402
44Poor eye contact (HP:0000817)2.17047296
45Cellulitis (HP:0100658)2.16912030
46Astrocytoma (HP:0009592)2.12024355
47Abnormality of the astrocytes (HP:0100707)2.12024355
48Asymmetry of the thorax (HP:0001555)2.12005965
49Gastrointestinal stroma tumor (HP:0100723)2.11637523
50Obsessive-compulsive behavior (HP:0000722)2.11001482
51Abnormality of the distal phalanx of the thumb (HP:0009617)2.10429872
52Abnormality of the thoracic spine (HP:0100711)2.09671086
53Abnormality of binocular vision (HP:0011514)2.09480143
54Diplopia (HP:0000651)2.09480143
55Persistence of primary teeth (HP:0006335)2.08592685
56Absence seizures (HP:0002121)2.07732706
57Ulnar bowing (HP:0003031)2.05950356
58Urethral obstruction (HP:0000796)2.04969723
59Centrally nucleated skeletal muscle fibers (HP:0003687)2.03611202
60Dysdiadochokinesis (HP:0002075)2.02243992
61Renovascular hypertension (HP:0100817)2.01702609
62Eczematoid dermatitis (HP:0000976)2.00472104
63Disproportionate tall stature (HP:0001519)1.99733739
64Inappropriate behavior (HP:0000719)1.99584749
65Scanning speech (HP:0002168)1.98540076
66Ankle clonus (HP:0011448)1.98489114
67Advanced eruption of teeth (HP:0006288)1.98038821
68Absent speech (HP:0001344)1.97429361
69Generalized tonic-clonic seizures (HP:0002069)1.96443627
70Long eyelashes (HP:0000527)1.95735214
71Ankyloglossia (HP:0010296)1.94512509
72Neurofibrillary tangles (HP:0002185)1.93855255
73Broad-based gait (HP:0002136)1.92634130
74Slow saccadic eye movements (HP:0000514)1.91141292
75Atonic seizures (HP:0010819)1.90275923
76Distal upper limb amyotrophy (HP:0007149)1.90160915
77Upper limb amyotrophy (HP:0009129)1.90160915
78Thoracic kyphosis (HP:0002942)1.89592153
79Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.89490551
80Dialeptic seizures (HP:0011146)1.88226587
81Increased connective tissue (HP:0009025)1.87940307
82Resting tremor (HP:0002322)1.87650262
83Germ cell neoplasia (HP:0100728)1.87360770
84Hand muscle atrophy (HP:0009130)1.86084629
85Open mouth (HP:0000194)1.83484879
86Dysmetria (HP:0001310)1.83295854
87Long palpebral fissure (HP:0000637)1.83182935
88Bronchomalacia (HP:0002780)1.81058815
89Dislocated radial head (HP:0003083)1.80618001
90Stereotypic behavior (HP:0000733)1.77754509
91Impaired vibratory sensation (HP:0002495)1.77545389
92Trigonocephaly (HP:0000243)1.76820361
93Aneurysm (HP:0002617)1.76501058
94Dysostosis multiplex (HP:0000943)1.75984852
95Osteolytic defects of the phalanges of the hand (HP:0009771)1.74962483
96Osteolytic defects of the hand bones (HP:0009699)1.74962483
97Hemiparesis (HP:0001269)1.74467331
98Syringomyelia (HP:0003396)1.73806206
99Spinal cord lesions (HP:0100561)1.73806206
100Protruding tongue (HP:0010808)1.73701292
101Protrusio acetabuli (HP:0003179)1.73127685
102Emphysema (HP:0002097)1.71945711
103Neonatal hypoglycemia (HP:0001998)1.70739158
104Spastic gait (HP:0002064)1.70677964
105Deep venous thrombosis (HP:0002625)1.70180956
106Myocardial infarction (HP:0001658)1.69495039
107Distal lower limb amyotrophy (HP:0008944)1.69240901
108Abnormality of oral frenula (HP:0000190)1.68791774
109Gastrointestinal inflammation (HP:0004386)1.68567767
110Thin bony cortex (HP:0002753)1.68350495
111Annular pancreas (HP:0001734)1.67676136
112Neoplasm of the heart (HP:0100544)1.66552046
113* Depression (HP:0000716)1.66344495
114Abnormality of the lumbar spine (HP:0100712)1.66257812
115Precocious puberty (HP:0000826)1.65803254
116Overriding aorta (HP:0002623)1.64886923
117Frequent falls (HP:0002359)1.63881558
118Bowel diverticulosis (HP:0005222)1.63661954
119Truncal obesity (HP:0001956)1.63642388
120Ocular albinism (HP:0001107)1.63576626
121Intention tremor (HP:0002080)1.63569761
122Mitral valve prolapse (HP:0001634)1.63245088
123Relative macrocephaly (HP:0004482)1.62766653
124Insidious onset (HP:0003587)1.62519008
125Termporal pattern (HP:0011008)1.62519008
126Glioma (HP:0009733)1.62444163
127Sparse lateral eyebrow (HP:0005338)1.60660335
128Abnormality of the nasal septum (HP:0000419)1.60308419
129Esophageal varix (HP:0002040)1.60246743
130Difficulty running (HP:0009046)1.59727067
131Natal tooth (HP:0000695)1.59572480
132Abnormality of the radial head (HP:0003995)1.58875208
133Hemorrhage of the eye (HP:0011885)1.58463903
134Interstitial pulmonary disease (HP:0006530)1.58241442
135Neoplasm of the adrenal cortex (HP:0100641)1.56859768
136Arnold-Chiari malformation (HP:0002308)1.56460281
137Abnormality of saccadic eye movements (HP:0000570)1.56452162
138Transitional cell carcinoma of the bladder (HP:0006740)1.55696555
139Widely spaced teeth (HP:0000687)1.55606601
140Urinary glycosaminoglycan excretion (HP:0003541)1.55575994
141Mucopolysacchariduria (HP:0008155)1.55575994
142Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.55464688
143Flat cornea (HP:0007720)1.55393688
144Subacute progressive viral hepatitis (HP:0006572)1.55235591
145Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.54749142
146Short 4th metacarpal (HP:0010044)1.54749142
147Inflammation of the large intestine (HP:0002037)1.53909799
148Bowel incontinence (HP:0002607)1.53620617
149Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.53414683
150Deep palmar crease (HP:0006191)1.52958982
151Viral hepatitis (HP:0006562)1.52751568
152Prominent nose (HP:0000448)1.52636753
153Metaphyseal cupping (HP:0003021)1.52620050
154Lower limb muscle weakness (HP:0007340)1.52142769
155Decreased motor nerve conduction velocity (HP:0003431)1.50544424
156Volvulus (HP:0002580)1.50511601
157Vertebral arch anomaly (HP:0008438)1.50007179
158Intellectual disability, profound (HP:0002187)1.48914685
159Large earlobe (HP:0009748)1.47793328
160Shallow orbits (HP:0000586)1.47760203
161Onion bulb formation (HP:0003383)1.46283544
162Increased variability in muscle fiber diameter (HP:0003557)1.45870688
163Overgrowth (HP:0001548)1.45732014
164Distal lower limb muscle weakness (HP:0009053)1.45619650
165Increased cerebral lipofuscin (HP:0011813)1.44912031
166Arterial tortuosity (HP:0005116)1.44676100
167Spontaneous hematomas (HP:0007420)1.44358377
168Supernumerary nipples (HP:0002558)1.44122112
169Achilles tendon contracture (HP:0001771)1.43588206
170Turricephaly (HP:0000262)1.43205127
171Gingivitis (HP:0000230)1.43081306
172Polygenic inheritance (HP:0010982)1.42957278
173IgA deficiency (HP:0002720)1.42561527
174Mitral regurgitation (HP:0001653)1.41645346

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.31067134
2SMG12.99594615
3CAMK1G2.84337774
4CDK122.66279462
5FGFR42.62448724
6MAP3K92.59845903
7SIK22.52677921
8MAP3K42.42142510
9CAMK1D2.29912280
10EPHA42.10660309
11PRKD32.08988815
12RIPK42.08383097
13DAPK22.05979701
14PAK61.95848206
15RIPK11.93070271
16STK381.85710493
17CAMKK11.84492213
18MAP3K131.78077459
19NTRK21.77224518
20BRD41.76362072
21ERN11.65771951
22MINK11.62689639
23JAK11.45504875
24ALK1.45067328
25KSR21.42795163
26SCYL21.40903746
27PRPF4B1.39388323
28EEF2K1.38735021
29PRKCH1.35284265
30FES1.35170425
31WNK11.29244731
32* SGK31.19119920
33KSR11.18773206
34MAP3K71.18758575
35MARK11.16395131
36IRAK31.15937733
37MAP2K41.14441751
38TYRO31.14206690
39FGFR31.11341807
40PNCK1.09829320
41RET1.08730992
42NEK91.07080357
43NTRK11.06884402
44ICK1.06278264
45MAP3K21.04702218
46MAP2K31.03963357
47TRIB31.00913281
48MAP2K71.00399963
49MARK20.99858105
50DAPK10.99754878
51* CDK50.98988857
52BLK0.98457817
53STK110.96493672
54CDC42BPA0.95836487
55PKN20.91685989
56* SGK10.90599662
57MAPK110.89446675
58BMX0.86702820
59CAMK40.83955887
60PDK10.82969928
61CDK40.81219079
62TNK20.80490056
63TAOK10.79776932
64LATS20.78254824
65* SGK20.78122991
66CAMKK20.77117185
67CAMK10.76968812
68PDGFRA0.76746095
69MELK0.76394579
70MAP3K10.75736544
71MTOR0.75031882
72PDGFRB0.74592063
73HCK0.74312254
74CSF1R0.71418197
75TRPM70.70757579
76MAPK100.68542350
77MAP3K140.67721192
78SIK10.67212893
79FGFR20.67056910
80PTK2B0.65626087
81PTK60.65014827
82MAPK120.63988530
83RPS6KA30.63987933
84JAK20.63711674
85RPS6KC10.62715160
86RPS6KL10.62715160
87TTN0.61843977
88BTK0.61329022
89TAOK30.61111034
90DMPK0.60987563
91MAP4K10.60641198
92RPS6KB20.60175106
93LMTK20.59475883
94MAP3K60.59383808
95MAP3K100.58980366
96MAPK80.58383326
97ZAP700.57593757
98PTK20.57371286
99RPS6KA20.55546925
100FYN0.54051213
101PRKCG0.54045307
102PDPK10.52366168
103EPHB10.51155479
104JAK30.50398782
105TAOK20.50309527
106GSK3B0.49503193
107CHUK0.47534560
108FRK0.47051008
109MAPK70.44598200
110RPS6KB10.44026810
111NEK60.43827262
112CDK60.43290308
113TYK20.43176929
114PRKDC0.42893029
115PRKCB0.42252557
116PRKAA10.42115099
117TBK10.42029811
118FGR0.41929499
119CSNK1D0.41116350
120PRKD20.40751627
121MAPK140.40673306
122RPS6KA60.40508964
123HIPK20.40217477
124CDK90.39740928
125SYK0.39716976
126DDR20.39668967
127DYRK1A0.39150647
128MAP3K80.39031373
129AKT30.38289530
130SRC0.37851816
131CSK0.37595420
132IRAK20.36950221
133PAK40.36104835
134MAPK130.36082937
135PLK20.35993064
136ERBB20.35603572
137PRKCZ0.34815341
138ARAF0.33046376
139CDK70.32865664
140MAP3K30.32523880
141IKBKE0.32044468

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.22858725
2Long-term potentiation_Homo sapiens_hsa047202.02635295
3Olfactory transduction_Homo sapiens_hsa047401.93731377
4Synaptic vesicle cycle_Homo sapiens_hsa047211.87566415
5Type II diabetes mellitus_Homo sapiens_hsa049301.85951796
6Circadian entrainment_Homo sapiens_hsa047131.85139047
7Glutamatergic synapse_Homo sapiens_hsa047241.77690608
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69481544
9Phosphatidylinositol signaling system_Homo sapiens_hsa040701.68132933
10Morphine addiction_Homo sapiens_hsa050321.67845549
11Other glycan degradation_Homo sapiens_hsa005111.65043999
12Salivary secretion_Homo sapiens_hsa049701.64598676
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.60943393
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58209717
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57247038
16GABAergic synapse_Homo sapiens_hsa047271.57072726
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49744940
18Insulin secretion_Homo sapiens_hsa049111.45993734
19Gastric acid secretion_Homo sapiens_hsa049711.43198598
20Cholinergic synapse_Homo sapiens_hsa047251.40678415
21Amphetamine addiction_Homo sapiens_hsa050311.40457534
22Glioma_Homo sapiens_hsa052141.34634178
23Dorso-ventral axis formation_Homo sapiens_hsa043201.31687212
24Dopaminergic synapse_Homo sapiens_hsa047281.29608140
25Notch signaling pathway_Homo sapiens_hsa043301.26152643
26Oxytocin signaling pathway_Homo sapiens_hsa049211.25555711
27mTOR signaling pathway_Homo sapiens_hsa041501.22722406
28Renin secretion_Homo sapiens_hsa049241.21866493
29Long-term depression_Homo sapiens_hsa047301.20744594
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20588264
31GnRH signaling pathway_Homo sapiens_hsa049121.20562186
32Thyroid cancer_Homo sapiens_hsa052161.19425109
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19065755
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18079794
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15411229
36ErbB signaling pathway_Homo sapiens_hsa040121.13609422
37Prostate cancer_Homo sapiens_hsa052151.12010474
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10715223
39cAMP signaling pathway_Homo sapiens_hsa040241.10315595
40Adherens junction_Homo sapiens_hsa045201.10280875
41Estrogen signaling pathway_Homo sapiens_hsa049151.10145673
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.09561425
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08063001
44Calcium signaling pathway_Homo sapiens_hsa040201.07019590
45Hepatitis B_Homo sapiens_hsa051611.06071123
46Taste transduction_Homo sapiens_hsa047421.04603345
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.03637198
48Focal adhesion_Homo sapiens_hsa045101.02713307
49Inositol phosphate metabolism_Homo sapiens_hsa005621.02270253
50Bladder cancer_Homo sapiens_hsa052191.01859264
51Small cell lung cancer_Homo sapiens_hsa052221.01646802
52Toxoplasmosis_Homo sapiens_hsa051451.00933422
53Cocaine addiction_Homo sapiens_hsa050300.99856260
54Influenza A_Homo sapiens_hsa051640.99311261
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.99228094
56Leishmaniasis_Homo sapiens_hsa051400.99187439
57Non-small cell lung cancer_Homo sapiens_hsa052230.97591286
58Prion diseases_Homo sapiens_hsa050200.97514998
59Hepatitis C_Homo sapiens_hsa051600.97235129
60Endometrial cancer_Homo sapiens_hsa052130.95943697
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95775350
62Nitrogen metabolism_Homo sapiens_hsa009100.95224532
63Chronic myeloid leukemia_Homo sapiens_hsa052200.94326898
64B cell receptor signaling pathway_Homo sapiens_hsa046620.94225718
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93251576
66Choline metabolism in cancer_Homo sapiens_hsa052310.92480885
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91464061
68Gap junction_Homo sapiens_hsa045400.91250266
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89781957
70Lysine degradation_Homo sapiens_hsa003100.89516676
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87011487
72MAPK signaling pathway_Homo sapiens_hsa040100.85668961
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.84281478
74Viral carcinogenesis_Homo sapiens_hsa052030.83799574
75Amoebiasis_Homo sapiens_hsa051460.83256168
76Apoptosis_Homo sapiens_hsa042100.82633791
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80865452
78AMPK signaling pathway_Homo sapiens_hsa041520.80815450
79Chemokine signaling pathway_Homo sapiens_hsa040620.80498304
80Osteoclast differentiation_Homo sapiens_hsa043800.80243793
81T cell receptor signaling pathway_Homo sapiens_hsa046600.79872346
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.79406879
83TNF signaling pathway_Homo sapiens_hsa046680.78150420
84Measles_Homo sapiens_hsa051620.77907512
85VEGF signaling pathway_Homo sapiens_hsa043700.77638602
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77530553
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76596016
88Melanogenesis_Homo sapiens_hsa049160.76140456
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71841906
90Thyroid hormone synthesis_Homo sapiens_hsa049180.70028028
91Prolactin signaling pathway_Homo sapiens_hsa049170.69725496
92Pancreatic secretion_Homo sapiens_hsa049720.69083090
93FoxO signaling pathway_Homo sapiens_hsa040680.68872014
94Pancreatic cancer_Homo sapiens_hsa052120.68421404
95Viral myocarditis_Homo sapiens_hsa054160.68150263
96HTLV-I infection_Homo sapiens_hsa051660.68098094
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68040928
98Rap1 signaling pathway_Homo sapiens_hsa040150.66961095
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.66631382
100Insulin signaling pathway_Homo sapiens_hsa049100.66323640
101Lysosome_Homo sapiens_hsa041420.66054034
102Colorectal cancer_Homo sapiens_hsa052100.65798811
103Dilated cardiomyopathy_Homo sapiens_hsa054140.65597034
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65092877
105Proteoglycans in cancer_Homo sapiens_hsa052050.64784903
106Platelet activation_Homo sapiens_hsa046110.64102295
107Axon guidance_Homo sapiens_hsa043600.64082691
108Endocytosis_Homo sapiens_hsa041440.64044499
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63599347
110Oocyte meiosis_Homo sapiens_hsa041140.63282999
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62577064
112Serotonergic synapse_Homo sapiens_hsa047260.62325067
113Insulin resistance_Homo sapiens_hsa049310.61187217
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.61131943
115Glucagon signaling pathway_Homo sapiens_hsa049220.61060648
116Renal cell carcinoma_Homo sapiens_hsa052110.59961253
117Fatty acid biosynthesis_Homo sapiens_hsa000610.59311484
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59123280
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.59104225
120Acute myeloid leukemia_Homo sapiens_hsa052210.58739644
121Herpes simplex infection_Homo sapiens_hsa051680.57738309
122Type I diabetes mellitus_Homo sapiens_hsa049400.55469284
123Tuberculosis_Homo sapiens_hsa051520.55176360
124Staphylococcus aureus infection_Homo sapiens_hsa051500.54682840
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54242788
126MicroRNAs in cancer_Homo sapiens_hsa052060.52973896
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52839842
128HIF-1 signaling pathway_Homo sapiens_hsa040660.50788384
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.50339838
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.50265924
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50246260
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49637176
133Bile secretion_Homo sapiens_hsa049760.49440016
134ECM-receptor interaction_Homo sapiens_hsa045120.46831846
135Pathways in cancer_Homo sapiens_hsa052000.43723668
136Epstein-Barr virus infection_Homo sapiens_hsa051690.43423899

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