HUNK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.95147758
2pyrimidine nucleobase catabolic process (GO:0006208)4.36621261
3paraxial mesoderm development (GO:0048339)4.35925456
4lateral sprouting from an epithelium (GO:0060601)4.26827265
5planar cell polarity pathway involved in neural tube closure (GO:0090179)3.98705762
6pre-miRNA processing (GO:0031054)3.89461892
7presynaptic membrane assembly (GO:0097105)3.76632907
8limb bud formation (GO:0060174)3.69978853
9postsynaptic membrane organization (GO:0001941)3.65714248
10regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.65001408
11regulation of posttranscriptional gene silencing (GO:0060147)3.56441223
12regulation of gene silencing by miRNA (GO:0060964)3.56441223
13regulation of gene silencing by RNA (GO:0060966)3.56441223
14presynaptic membrane organization (GO:0097090)3.49467470
15nucleobase catabolic process (GO:0046113)3.48014206
16somite development (GO:0061053)3.43898110
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.43563159
18cell migration in hindbrain (GO:0021535)3.37126683
19anterior/posterior axis specification, embryo (GO:0008595)3.23561217
20negative regulation of translation, ncRNA-mediated (GO:0040033)3.23338542
21regulation of translation, ncRNA-mediated (GO:0045974)3.23338542
22negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.23338542
23peptidyl-arginine omega-N-methylation (GO:0035247)3.19682846
24establishment or maintenance of monopolar cell polarity (GO:0061339)3.15015628
25establishment of monopolar cell polarity (GO:0061162)3.15015628
26convergent extension (GO:0060026)3.14119714
27L-fucose catabolic process (GO:0042355)3.09088459
28fucose catabolic process (GO:0019317)3.09088459
29L-fucose metabolic process (GO:0042354)3.09088459
30positive regulation of synapse maturation (GO:0090129)3.08640874
31establishment of apical/basal cell polarity (GO:0035089)3.08127813
32peptidyl-arginine N-methylation (GO:0035246)3.07591521
33peptidyl-arginine methylation (GO:0018216)3.07591521
34spinal cord development (GO:0021510)3.04377186
35response to pheromone (GO:0019236)3.02753706
36regulation of hippo signaling (GO:0035330)3.02381263
37sympathetic nervous system development (GO:0048485)3.02329648
38polarized epithelial cell differentiation (GO:0030859)3.01065901
39retinal ganglion cell axon guidance (GO:0031290)3.00269241
40axonal fasciculation (GO:0007413)2.99612146
41behavioral response to ethanol (GO:0048149)2.98683853
42cornea development in camera-type eye (GO:0061303)2.94267871
43establishment of tissue polarity (GO:0007164)2.94141836
44establishment of planar polarity (GO:0001736)2.94141836
45histone arginine methylation (GO:0034969)2.93465457
46neural tube formation (GO:0001841)2.92456064
47kidney morphogenesis (GO:0060993)2.91842021
48negative regulation of transcription regulatory region DNA binding (GO:2000678)2.90143025
49neuron cell-cell adhesion (GO:0007158)2.89120346
50detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.88740121
51G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.87372671
52inner ear receptor stereocilium organization (GO:0060122)2.87214177
53cochlea morphogenesis (GO:0090103)2.86261331
54synaptic transmission, cholinergic (GO:0007271)2.79800645
55Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.76165755
56hippo signaling (GO:0035329)2.75571850
57retinal cone cell development (GO:0046549)2.74946071
58transmission of nerve impulse (GO:0019226)2.74548114
59non-canonical Wnt signaling pathway (GO:0035567)2.74443672
60cell migration involved in gastrulation (GO:0042074)2.71397666
61notochord development (GO:0030903)2.70997501
62establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.70741724
63protein polyglutamylation (GO:0018095)2.69489380
64spinal cord motor neuron differentiation (GO:0021522)2.69477840
65regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.68041090
66central nervous system projection neuron axonogenesis (GO:0021952)2.67754809
67regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.63050677
68regulation of NFAT protein import into nucleus (GO:0051532)2.63033645
69apical protein localization (GO:0045176)2.61963049
70regulation of establishment of planar polarity (GO:0090175)2.60977887
71auditory behavior (GO:0031223)2.59513196
72central nervous system neuron axonogenesis (GO:0021955)2.58541541
73protein localization to synapse (GO:0035418)2.58417406
74neuron recognition (GO:0008038)2.58145586
75nuclear pore organization (GO:0006999)2.57820567
76appendage development (GO:0048736)2.57799191
77limb development (GO:0060173)2.57799191
78body morphogenesis (GO:0010171)2.57416821
79sister chromatid segregation (GO:0000819)2.57177244
80regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.57146641
81nonmotile primary cilium assembly (GO:0035058)2.56371293
82indolalkylamine metabolic process (GO:0006586)2.56042749
83layer formation in cerebral cortex (GO:0021819)2.55540931
84negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.55485629
85hindlimb morphogenesis (GO:0035137)2.54669553
86mitotic sister chromatid segregation (GO:0000070)2.54175098
87synaptic vesicle docking involved in exocytosis (GO:0016081)2.52566033
88negative regulation of cytosolic calcium ion concentration (GO:0051481)2.52540055
89mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.52376684
90neuronal action potential (GO:0019228)2.50906767
91regulation of non-canonical Wnt signaling pathway (GO:2000050)2.50457997
92dendritic spine morphogenesis (GO:0060997)2.50300507
93proximal/distal pattern formation (GO:0009954)2.49601128
94hindbrain development (GO:0030902)2.49580561
95regulation of action potential (GO:0098900)2.49555215
96centriole replication (GO:0007099)2.49367182
97nuclear pore complex assembly (GO:0051292)2.47211639
98lung-associated mesenchyme development (GO:0060484)2.45973598
99intraciliary transport (GO:0042073)2.45944210
100DNA double-strand break processing (GO:0000729)2.45277694
101synapse assembly (GO:0007416)2.45206826
102neuromuscular synaptic transmission (GO:0007274)2.44871386
103piRNA metabolic process (GO:0034587)2.43351704
104negative regulation of axon guidance (GO:1902668)2.41993824
105outer ear morphogenesis (GO:0042473)2.41915172
106cilium organization (GO:0044782)2.41661683
107gamma-aminobutyric acid transport (GO:0015812)2.41293852
108embryonic hindlimb morphogenesis (GO:0035116)2.40618690
109photoreceptor cell development (GO:0042461)2.40211943
110cilium morphogenesis (GO:0060271)2.40193994
111positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.39625442
112regulation of timing of cell differentiation (GO:0048505)2.38769401
113tube closure (GO:0060606)2.38183064
114regulation of DNA endoreduplication (GO:0032875)2.37981348
115regulation of cilium movement (GO:0003352)2.37898337
116negative regulation of DNA-dependent DNA replication (GO:2000104)2.37658800
117neural tube closure (GO:0001843)2.37599894
118cilium assembly (GO:0042384)2.37363284
119regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.37074882
120indole-containing compound catabolic process (GO:0042436)2.36863117
121indolalkylamine catabolic process (GO:0046218)2.36863117
122tryptophan catabolic process (GO:0006569)2.36863117
123innervation (GO:0060384)2.36722595
124regulation of synapse maturation (GO:0090128)2.36513408
125olfactory bulb development (GO:0021772)2.36091122
126ephrin receptor signaling pathway (GO:0048013)2.35772866
127thalamus development (GO:0021794)2.35222572
128regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.34209311
129cerebral cortex development (GO:0021987)2.33714964
130negative regulation of catenin import into nucleus (GO:0035414)2.32822328
131kynurenine metabolic process (GO:0070189)2.32814830
132membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.32533653
133head development (GO:0060322)2.32060264
134regulation of sister chromatid cohesion (GO:0007063)2.30822744
135cochlea development (GO:0090102)2.30436991
136regulation of respiratory system process (GO:0044065)2.30371797
137serotonin metabolic process (GO:0042428)2.29607927
138synaptic transmission, glutamatergic (GO:0035249)2.29227966
139glutamate receptor signaling pathway (GO:0007215)2.28917288
140axoneme assembly (GO:0035082)2.28765986
141spliceosomal tri-snRNP complex assembly (GO:0000244)2.28333725
142cell differentiation in spinal cord (GO:0021515)2.28067601
143proline transport (GO:0015824)2.27803470
144short-term memory (GO:0007614)2.27762700
145protein localization to cilium (GO:0061512)2.27223230
146cellular response to sterol (GO:0036315)2.26970664
147regulation of nuclear cell cycle DNA replication (GO:0033262)2.26366488
148mechanosensory behavior (GO:0007638)2.26324558
149regulation of mesoderm development (GO:2000380)2.26282975
150gastrulation with mouth forming second (GO:0001702)2.26118190
151vocalization behavior (GO:0071625)2.25855309
152G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.25594381
153forebrain neuron differentiation (GO:0021879)2.25305805
154detection of light stimulus involved in visual perception (GO:0050908)2.25154070
155detection of light stimulus involved in sensory perception (GO:0050962)2.25154070
156anterior/posterior axis specification (GO:0009948)2.24441409
157bone trabecula formation (GO:0060346)2.23926897
158indole-containing compound metabolic process (GO:0042430)2.23767457
159negative regulation of astrocyte differentiation (GO:0048712)2.22822474
160regulation of development, heterochronic (GO:0040034)2.22197452
161embryonic camera-type eye development (GO:0031076)2.22135096
162mesenchymal cell proliferation (GO:0010463)2.22093988
163craniofacial suture morphogenesis (GO:0097094)2.20751664
164negative regulation of mRNA processing (GO:0050686)2.20162133
165negative regulation of DNA repair (GO:0045738)2.19208181
166startle response (GO:0001964)2.18670744
167embryonic foregut morphogenesis (GO:0048617)2.18087229
168negative regulation of chondrocyte differentiation (GO:0032331)2.17843573
169inner ear receptor cell development (GO:0060119)2.17669021
170negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.15032784
171cilium movement (GO:0003341)2.14599312
172dorsal/ventral axis specification (GO:0009950)2.14493821
173organ induction (GO:0001759)2.14119353
174ventricular system development (GO:0021591)2.13489960
175mesenchyme development (GO:0060485)2.12104952
176pituitary gland development (GO:0021983)2.11778950
177negative regulation of smoothened signaling pathway (GO:0045879)2.11461410
178regulation of glutamate receptor signaling pathway (GO:1900449)2.10770777
179trophectodermal cell differentiation (GO:0001829)2.10502394
180regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.09921105
181embryonic body morphogenesis (GO:0010172)2.09557138
182epithelial cilium movement (GO:0003351)2.09021258
183mesenchymal to epithelial transition (GO:0060231)2.08928883
184positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.08420973
185negative regulation of axon extension involved in axon guidance (GO:0048843)2.08048542
186embryonic digit morphogenesis (GO:0042733)2.07857751

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.76429428
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.16324839
3VDR_22108803_ChIP-Seq_LS180_Human3.02868995
4* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.92674665
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.74841333
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62592128
7IGF1R_20145208_ChIP-Seq_DFB_Human2.54212296
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.52149345
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.52149345
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.52149345
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50667001
12* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.41970072
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29186066
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24386008
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.19859450
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.18932845
17TAF15_26573619_Chip-Seq_HEK293_Human2.16153554
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.12324852
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.06927085
20* P300_19829295_ChIP-Seq_ESCs_Human2.05933847
21EWS_26573619_Chip-Seq_HEK293_Human2.03148282
22SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.01930449
23SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.95386827
24GBX2_23144817_ChIP-Seq_PC3_Human1.93631431
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.91089719
26* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88934151
27SOX2_18555785_ChIP-Seq_MESCs_Mouse1.86181982
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.85532729
29* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.83466952
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81584735
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81049459
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77950717
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77620846
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72773761
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72773761
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.72472763
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.71697729
38E2F7_22180533_ChIP-Seq_HELA_Human1.70823946
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.68924143
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67976546
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66540588
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66143692
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66143062
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65831539
45SMAD4_21799915_ChIP-Seq_A2780_Human1.63963443
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.63948088
47ZFP281_27345836_Chip-Seq_ESCs_Mouse1.62068132
48TCF3_18692474_ChIP-Seq_MESCs_Mouse1.61340463
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59445899
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58235086
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57734675
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55880298
53* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54028779
54RING1B_27294783_Chip-Seq_NPCs_Mouse1.53396258
55FUS_26573619_Chip-Seq_HEK293_Human1.53251214
56ER_23166858_ChIP-Seq_MCF-7_Human1.53132027
57POU5F1_16518401_ChIP-PET_MESCs_Mouse1.52504866
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.51971216
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.51363861
60TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51124847
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.50681164
62* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50412557
63BCAT_22108803_ChIP-Seq_LS180_Human1.49531104
64NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.49284812
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48542997
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48030062
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47355524
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.47172227
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46670921
70AR_21572438_ChIP-Seq_LNCaP_Human1.46488854
71* ISL1_27105846_Chip-Seq_CPCs_Mouse1.45869045
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.45521834
73STAT3_23295773_ChIP-Seq_U87_Human1.45013535
74AR_25329375_ChIP-Seq_VCAP_Human1.44907520
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44063446
76SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42022023
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41897177
78TP53_20018659_ChIP-ChIP_R1E_Mouse1.41760132
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41605813
80TCF4_23295773_ChIP-Seq_U87_Human1.41491669
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38421831
82POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.37748325
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36087777
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.35659924
85SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33859745
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33512464
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32864201
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32488804
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32370443
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32274993
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32037887
92TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.31283076
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30762828
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30074707
95CBP_20019798_ChIP-Seq_JUKART_Human1.30074707
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29710437
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29419892
98* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28817938
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27707870
100RNF2_27304074_Chip-Seq_NSC_Mouse1.26998359
101RUNX2_22187159_ChIP-Seq_PCA_Human1.26822507
102REST_21632747_ChIP-Seq_MESCs_Mouse1.26810795
103TCF4_22108803_ChIP-Seq_LS180_Human1.26651273
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26413046
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26267881
106RING1B_27294783_Chip-Seq_ESCs_Mouse1.24109418
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23518198
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23366479
109E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22810643
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20832958
111CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20598439
112IRF1_19129219_ChIP-ChIP_H3396_Human1.19501492
113* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19344946
114* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17645914
115* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.16468971
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15918522
117RARB_27405468_Chip-Seq_BRAIN_Mouse1.13546203
118CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13476823
119NANOG_21062744_ChIP-ChIP_HESCs_Human1.13234215
120SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13007647
121KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12905523
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12793084
123* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12449281
124FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.12085425
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11814851
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11467589
127EZH2_27294783_Chip-Seq_ESCs_Mouse1.10140901
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09698480
129KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09371406
130NANOG_18555785_Chip-Seq_ESCs_Mouse1.08481175
131STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08338086
132SOX2_21211035_ChIP-Seq_LN229_Gbm1.08087535
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08018776
134POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08018776
135ZNF274_21170338_ChIP-Seq_K562_Hela1.07766130
136TP53_22573176_ChIP-Seq_HFKS_Human1.07139823
137SMAD4_21741376_ChIP-Seq_EPCs_Human1.06120742
138* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03996452
139* SOX2_19829295_ChIP-Seq_ESCs_Human1.02435755
140* NANOG_19829295_ChIP-Seq_ESCs_Human1.02435755
141* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02276241
142YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01739793
143NFE2_27457419_Chip-Seq_LIVER_Mouse1.01628014
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01447565
145EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01406753
146SOX9_26525672_Chip-Seq_HEART_Mouse1.00935231
147FLI1_21867929_ChIP-Seq_TH2_Mouse0.99759341
148MYC_18940864_ChIP-ChIP_HL60_Human0.99660066
149* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99492149
150SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99119856
151EZH2_27294783_Chip-Seq_NPCs_Mouse0.98455748
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.98342622
153* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98134000
154BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97979419
155* REST_18959480_ChIP-ChIP_MESCs_Mouse0.96669335
156FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.96536439
157NANOG_16518401_ChIP-PET_MESCs_Mouse0.96479322
158NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.95051742
159* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94856269
160SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94740700
161ARNT_22903824_ChIP-Seq_MCF-7_Human0.94730000
162* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94311166
163RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93962307
164AR_19668381_ChIP-Seq_PC3_Human0.93004811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology3.03098049
2MP0003123_paternal_imprinting2.87384057
3MP0010030_abnormal_orbit_morphology2.86193465
4MP0002653_abnormal_ependyma_morphology2.79193187
5MP0003122_maternal_imprinting2.64533008
6MP0002102_abnormal_ear_morphology2.34960277
7MP0009053_abnormal_anal_canal2.26904614
8MP0003121_genomic_imprinting2.25786671
9MP0003119_abnormal_digestive_system2.11837552
10MP0004859_abnormal_synaptic_plasticity2.10292386
11MP0003890_abnormal_embryonic-extraembry2.05217375
12MP0002638_abnormal_pupillary_reflex1.93858401
13MP0003136_yellow_coat_color1.91587016
14MP0001968_abnormal_touch/_nociception1.88420603
15MP0004133_heterotaxia1.86196292
16MP0005551_abnormal_eye_electrophysiolog1.84346620
17MP0000778_abnormal_nervous_system1.82148759
18MP0000049_abnormal_middle_ear1.78788139
19MP0003385_abnormal_body_wall1.76935513
20MP0005646_abnormal_pituitary_gland1.74883550
21MP0006292_abnormal_olfactory_placode1.74698785
22MP0002736_abnormal_nociception_after1.74084351
23MP0003942_abnormal_urinary_system1.74051359
24MP0006276_abnormal_autonomic_nervous1.70687584
25MP0003787_abnormal_imprinting1.69933591
26MP0002249_abnormal_larynx_morphology1.69516971
27MP0008789_abnormal_olfactory_epithelium1.67951271
28MP0005499_abnormal_olfactory_system1.65826330
29MP0005394_taste/olfaction_phenotype1.65826330
30MP0003941_abnormal_skin_development1.64314985
31MP0002272_abnormal_nervous_system1.64164060
32MP0000566_synostosis1.60441777
33MP0003283_abnormal_digestive_organ1.60292377
34MP0000534_abnormal_ureter_morphology1.59370498
35MP0003937_abnormal_limbs/digits/tail_de1.58695978
36MP0003880_abnormal_central_pattern1.55891793
37MP0005623_abnormal_meninges_morphology1.54515550
38MP0003195_calcinosis1.54386420
39MP0000569_abnormal_digit_pigmentation1.53107916
40MP0001293_anophthalmia1.51860624
41MP0005187_abnormal_penis_morphology1.50799473
42MP0003861_abnormal_nervous_system1.50282293
43MP0001486_abnormal_startle_reflex1.49251588
44MP0001984_abnormal_olfaction1.48375345
45MP0005253_abnormal_eye_physiology1.47271913
46MP0003755_abnormal_palate_morphology1.47116271
47MP0004885_abnormal_endolymph1.44352072
48MP0000516_abnormal_urinary_system1.43144171
49MP0005367_renal/urinary_system_phenotyp1.43144171
50MP0001529_abnormal_vocalization1.42499347
51MP0003938_abnormal_ear_development1.42362474
52MP0002084_abnormal_developmental_patter1.41281566
53MP0002557_abnormal_social/conspecific_i1.41131168
54MP0003011_delayed_dark_adaptation1.39201296
55MP0002938_white_spotting1.39074312
56MP0005248_abnormal_Harderian_gland1.35452196
57MP0002734_abnormal_mechanical_nocicepti1.35355071
58MP0004233_abnormal_muscle_weight1.35016134
59MP0000427_abnormal_hair_cycle1.34659723
60MP0002085_abnormal_embryonic_tissue1.34593522
61MP0002735_abnormal_chemical_nociception1.34090576
62MP0004742_abnormal_vestibular_system1.33529123
63MP0003635_abnormal_synaptic_transmissio1.33486672
64MP0001485_abnormal_pinna_reflex1.33086408
65MP0005423_abnormal_somatic_nervous1.32744473
66MP0000762_abnormal_tongue_morphology1.32620311
67MP0003115_abnormal_respiratory_system1.31857337
68MP0003935_abnormal_craniofacial_develop1.31143143
69MP0005645_abnormal_hypothalamus_physiol1.28392323
70MP0002233_abnormal_nose_morphology1.27829812
71MP0001501_abnormal_sleep_pattern1.27826489
72MP0002116_abnormal_craniofacial_bone1.27722000
73MP0004858_abnormal_nervous_system1.27295544
74MP0002282_abnormal_trachea_morphology1.26761110
75MP0004270_analgesia1.26433307
76MP0003315_abnormal_perineum_morphology1.26120635
77MP0009250_abnormal_appendicular_skeleto1.25988525
78MP0002184_abnormal_innervation1.22715406
79MP0002063_abnormal_learning/memory/cond1.21767934
80MP0000428_abnormal_craniofacial_morphol1.21483362
81MP0003878_abnormal_ear_physiology1.20996288
82MP0005377_hearing/vestibular/ear_phenot1.20996288
83MP0008872_abnormal_physiological_respon1.20734723
84MP0004142_abnormal_muscle_tone1.20232208
85MP0002752_abnormal_somatic_nervous1.17410307
86MP0008877_abnormal_DNA_methylation1.16859976
87MP0004957_abnormal_blastocyst_morpholog1.15957368
88MP0002932_abnormal_joint_morphology1.15739644
89MP0004264_abnormal_extraembryonic_tissu1.15605634
90MP0004197_abnormal_fetal_growth/weight/1.14100316
91MP0001286_abnormal_eye_development1.10625884
92MP0002067_abnormal_sensory_capabilities1.10564948
93MP0009046_muscle_twitch1.09951560
94MP0001672_abnormal_embryogenesis/_devel1.09615275
95MP0005380_embryogenesis_phenotype1.09615275
96MP0000647_abnormal_sebaceous_gland1.09347290
97MP0001970_abnormal_pain_threshold1.09210109
98MP0000432_abnormal_head_morphology1.08895035
99MP0000678_abnormal_parathyroid_gland1.08582594
100MP0002152_abnormal_brain_morphology1.08536538
101MP0003705_abnormal_hypodermis_morpholog1.08047828
102MP0006072_abnormal_retinal_apoptosis1.07771844
103MP0000383_abnormal_hair_follicle1.07742378
104MP0000372_irregular_coat_pigmentation1.05664607
105MP0010386_abnormal_urinary_bladder1.05589961
106MP0002697_abnormal_eye_size1.04552675
107MP0000955_abnormal_spinal_cord1.03012242
108MP0002111_abnormal_tail_morphology1.02683704
109MP0003567_abnormal_fetal_cardiomyocyte1.01568771
110MP0000026_abnormal_inner_ear0.99455963
111MP0003718_maternal_effect0.99013834
112MP0002733_abnormal_thermal_nociception0.98953188
113MP0001697_abnormal_embryo_size0.98804570
114MP0003111_abnormal_nucleus_morphology0.98763605
115MP0000631_abnormal_neuroendocrine_gland0.97744180
116MP0004043_abnormal_pH_regulation0.97311948
117MP0002572_abnormal_emotion/affect_behav0.96777374
118MP0002114_abnormal_axial_skeleton0.96448194
119MP0002160_abnormal_reproductive_system0.96350308
120MP0004272_abnormal_basement_membrane0.95742344
121MP0002822_catalepsy0.95668355
122MP0001188_hyperpigmentation0.95599698
123MP0005386_behavior/neurological_phenoty0.95582745
124MP0004924_abnormal_behavior0.95582745
125MP0005195_abnormal_posterior_eye0.95547529
126MP0001849_ear_inflammation0.94439386
127MP0002751_abnormal_autonomic_nervous0.94168575
128MP0005391_vision/eye_phenotype0.93889342
129MP0002081_perinatal_lethality0.93800430
130MP0005084_abnormal_gallbladder_morpholo0.93729553
131MP0003984_embryonic_growth_retardation0.93069648
132MP0002088_abnormal_embryonic_growth/wei0.92848660
133MP0002837_dystrophic_cardiac_calcinosis0.92319043
134MP0002876_abnormal_thyroid_physiology0.92095216
135MP0002882_abnormal_neuron_morphology0.90839601
136MP0002909_abnormal_adrenal_gland0.90098676
137MP0001299_abnormal_eye_distance/0.90018885
138MP0008932_abnormal_embryonic_tissue0.89506383
139MP0002086_abnormal_extraembryonic_tissu0.89468327
140MP0008995_early_reproductive_senescence0.89075672
141MP0009745_abnormal_behavioral_response0.88580227
142MP0002234_abnormal_pharynx_morphology0.87552821
143MP0001730_embryonic_growth_arrest0.86451522
144MP0008057_abnormal_DNA_replication0.85316263
145MP0000462_abnormal_digestive_system0.85310208
146MP0002092_abnormal_eye_morphology0.84892149
147MP0002064_seizures0.83656429
148MP0005076_abnormal_cell_differentiation0.83415050
149MP0009703_decreased_birth_body0.81532611
150MP0004811_abnormal_neuron_physiology0.81411805

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.54639559
2Pancreatic fibrosis (HP:0100732)3.42575669
3Molar tooth sign on MRI (HP:0002419)3.36472986
4Abnormality of midbrain morphology (HP:0002418)3.36472986
5True hermaphroditism (HP:0010459)3.18484191
6Nephronophthisis (HP:0000090)3.17089031
7Short 4th metacarpal (HP:0010044)3.14874525
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.14874525
9Abnormality of the labia minora (HP:0012880)3.14713395
10Abnormality of the lower motor neuron (HP:0002366)3.01800072
11Renal duplication (HP:0000075)2.93881969
12Abnormality of the renal medulla (HP:0100957)2.74520774
13Chronic hepatic failure (HP:0100626)2.61968530
14Hepatoblastoma (HP:0002884)2.59663149
15Supernumerary spleens (HP:0009799)2.56661262
16Congenital stationary night blindness (HP:0007642)2.56068408
17Midline defect of the nose (HP:0004122)2.55241461
18Anophthalmia (HP:0000528)2.54404806
19Broad-based gait (HP:0002136)2.52428954
20Abnormality of the renal cortex (HP:0011035)2.50483193
21Type II lissencephaly (HP:0007260)2.45192474
22Abnormality of the 4th metacarpal (HP:0010012)2.43747053
23Hypoplastic labia majora (HP:0000059)2.43441869
24Patellar aplasia (HP:0006443)2.43157589
25Rib fusion (HP:0000902)2.42777086
26Cystic liver disease (HP:0006706)2.41100790
27Pendular nystagmus (HP:0012043)2.39890321
28Bilateral microphthalmos (HP:0007633)2.38528174
29Absent/shortened dynein arms (HP:0200106)2.34157947
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.34157947
31Progressive cerebellar ataxia (HP:0002073)2.31610715
32Supernumerary ribs (HP:0005815)2.30927026
33Abnormal number of incisors (HP:0011064)2.28750327
34Bifid tongue (HP:0010297)2.28653784
35Focal seizures (HP:0007359)2.27423706
36Aplasia/Hypoplasia of the patella (HP:0006498)2.27346537
37Optic nerve hypoplasia (HP:0000609)2.26066158
38Lissencephaly (HP:0001339)2.25446018
39Anencephaly (HP:0002323)2.23252033
40Gaze-evoked nystagmus (HP:0000640)2.22692204
41Labial hypoplasia (HP:0000066)2.22494568
42Cutaneous finger syndactyly (HP:0010554)2.19980945
43Abnormality of the diencephalon (HP:0010662)2.18348735
44Colon cancer (HP:0003003)2.17209822
45Facial hemangioma (HP:0000329)2.16793077
46Esophageal atresia (HP:0002032)2.16316278
47Supernumerary bones of the axial skeleton (HP:0009144)2.15852621
48Abnormality of the labia majora (HP:0012881)2.15610391
49Trigonocephaly (HP:0000243)2.14117201
50Shallow orbits (HP:0000586)2.13153096
51Genetic anticipation (HP:0003743)2.12847917
52Medulloblastoma (HP:0002885)2.12727996
53Medial flaring of the eyebrow (HP:0010747)2.12398838
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.12337185
55Focal motor seizures (HP:0011153)2.11986083
56Ependymoma (HP:0002888)2.11385008
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.11007610
58Drooling (HP:0002307)2.10771471
59Cerebellar dysplasia (HP:0007033)2.10691539
60Inability to walk (HP:0002540)2.10484157
61Sclerocornea (HP:0000647)2.09067566
62Shawl scrotum (HP:0000049)2.09049597
63Hyperventilation (HP:0002883)2.06493024
64Aplasia/Hypoplasia of the tongue (HP:0010295)2.06171422
65Hypoplastic female external genitalia (HP:0012815)2.05378206
66Genital tract atresia (HP:0001827)2.02931589
67Volvulus (HP:0002580)2.02796475
68Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01705107
69Nephroblastoma (Wilms tumor) (HP:0002667)2.01697850
70Oligodactyly (hands) (HP:0001180)2.01500727
71Attenuation of retinal blood vessels (HP:0007843)2.00959524
72Abnormality of the astrocytes (HP:0100707)1.99924150
73Astrocytoma (HP:0009592)1.99924150
74Abnormality of the parietal bone (HP:0002696)1.98995944
75Embryonal renal neoplasm (HP:0011794)1.98270979
76Broad thumb (HP:0011304)1.97744200
77Tubular atrophy (HP:0000092)1.97143115
78Abnormality of the aortic arch (HP:0012303)1.96393090
79Short humerus (HP:0005792)1.95948738
80Aplasia/Hypoplasia of the sternum (HP:0006714)1.95618663
81Preaxial hand polydactyly (HP:0001177)1.95357127
82Increased corneal curvature (HP:0100692)1.95303560
83Keratoconus (HP:0000563)1.95303560
84Abnormality of the distal phalanx of the thumb (HP:0009617)1.95058699
85Progressive inability to walk (HP:0002505)1.94862154
86Cutaneous syndactyly (HP:0012725)1.93998300
87Abnormal respiratory motile cilium morphology (HP:0005938)1.92288258
88Abnormal respiratory epithelium morphology (HP:0012253)1.92288258
89Postaxial foot polydactyly (HP:0001830)1.90778474
90Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.90764364
91Vaginal atresia (HP:0000148)1.90438333
92Pachygyria (HP:0001302)1.88821555
93Abnormal lung lobation (HP:0002101)1.87760407
94Protruding tongue (HP:0010808)1.87613187
95Short phalanx of the thumb (HP:0009660)1.86828586
96Gastrointestinal atresia (HP:0002589)1.86418327
97Small hand (HP:0200055)1.86305179
98Morphological abnormality of the middle ear (HP:0008609)1.85297709
99Hypoplastic ischia (HP:0003175)1.85179049
100Aplasia/hypoplasia of the humerus (HP:0006507)1.84827052
101Selective tooth agenesis (HP:0001592)1.83774871
102Broad toe (HP:0001837)1.83416587
103Occipital encephalocele (HP:0002085)1.82821878
104Dandy-Walker malformation (HP:0001305)1.82381209
105Septo-optic dysplasia (HP:0100842)1.82331798
106Decreased central vision (HP:0007663)1.81622794
107Renal cortical cysts (HP:0000803)1.81473547
108Abolished electroretinogram (ERG) (HP:0000550)1.81471705
109Excessive salivation (HP:0003781)1.80593369
110Abnormality of the antihelix (HP:0009738)1.80215611
111Abnormality of the phalanges of the hallux (HP:0010057)1.80134060
112Absent speech (HP:0001344)1.79731826
113Hemivertebrae (HP:0002937)1.79631028
114Increased nuchal translucency (HP:0010880)1.79293389
115Abnormality of the ileum (HP:0001549)1.79229840
116Retinal dysplasia (HP:0007973)1.79187443
117Postaxial hand polydactyly (HP:0001162)1.78955176
118Meckel diverticulum (HP:0002245)1.78531580
119Glioma (HP:0009733)1.77901361
120Narrow forehead (HP:0000341)1.77240323
121Gait imbalance (HP:0002141)1.76491322
122Preaxial foot polydactyly (HP:0001841)1.74882926
123Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.74618884
124Epileptic encephalopathy (HP:0200134)1.74482149
125Bronchomalacia (HP:0002780)1.74135430
126Neoplasm of the oral cavity (HP:0100649)1.73919970
127Abnormality of the nasal septum (HP:0000419)1.73892514
128Abnormality of the pubic bones (HP:0003172)1.72937220
129Amyotrophic lateral sclerosis (HP:0007354)1.72257498
130Abnormal ciliary motility (HP:0012262)1.72116938
131Concave nail (HP:0001598)1.71082100
132Coronal craniosynostosis (HP:0004440)1.69145116
133Renal hypoplasia (HP:0000089)1.68798463
134Broad alveolar ridges (HP:0000187)1.68716986
135Abnormality of the labia (HP:0000058)1.68604672
136Abnormality of the ischium (HP:0003174)1.67982721
137Abnormal drinking behavior (HP:0030082)1.67618012
138Polydipsia (HP:0001959)1.67618012
139Omphalocele (HP:0001539)1.67604031
140Partial agenesis of the corpus callosum (HP:0001338)1.67504413
141Abnormality of the phalanges of the 2nd finger (HP:0009541)1.66934879
142Atresia of the external auditory canal (HP:0000413)1.66922890
143Abnormality of abdominal situs (HP:0011620)1.66646452
144Abdominal situs inversus (HP:0003363)1.66646452
145Dialeptic seizures (HP:0011146)1.66337004
146Broad phalanges of the hand (HP:0009768)1.66124061
147Bony spicule pigmentary retinopathy (HP:0007737)1.65115713
148High anterior hairline (HP:0009890)1.63536116
149Alacrima (HP:0000522)1.63039483
150Skin pits (HP:0100276)1.63037846
151Broad finger (HP:0001500)1.63028398
152Neoplasm of striated muscle (HP:0009728)1.62045806
153Aqueductal stenosis (HP:0002410)1.60937281
154Facial cleft (HP:0002006)1.59744819
155Febrile seizures (HP:0002373)1.59685908
156Short 1st metacarpal (HP:0010034)1.59671328
157Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.59671328
158Absent forearm bone (HP:0003953)1.59144454
159Aplasia involving forearm bones (HP:0009822)1.59144454
160Absent radius (HP:0003974)1.59063300
161Periauricular skin pits (HP:0100277)1.59040981
162Preauricular pit (HP:0004467)1.59040981
163Abnormality of the right ventricle (HP:0001707)1.58906867
164Annular pancreas (HP:0001734)1.58719606
165Pointed chin (HP:0000307)1.58636734
166Ectopic anus (HP:0004397)1.58474739
167Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.57929169
168Short 5th finger (HP:0009237)1.57720631
169Oligodactyly (HP:0012165)1.57571243
170Chorioretinal atrophy (HP:0000533)1.57545323
171Intestinal atresia (HP:0011100)1.56725711
172Abnormality of the nasolacrimal system (HP:0000614)1.56252279
173Absent eyebrow (HP:0002223)1.56145589
174Pseudobulbar signs (HP:0002200)1.55701929
175Rectal fistula (HP:0100590)1.54677516
176Rectovaginal fistula (HP:0000143)1.54677516
177Abnormality of the lacrimal duct (HP:0011481)1.54579128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.50352949
2CDK123.02332480
3EPHA42.54918902
4LATS22.53218821
5CASK2.52395160
6ADRBK22.24822153
7NTRK32.21871084
8NUAK12.21538389
9ZAK2.15355802
10ACVR1B2.10254309
11DDR22.02400092
12AKT32.02205533
13LATS11.99998995
14TSSK61.98914503
15PINK11.98174282
16EPHB21.93145809
17MAP4K21.93104906
18MAP3K41.92761887
19PNCK1.90869916
20TNIK1.90324602
21MAPK131.88837632
22FGFR21.78351628
23TRIM281.76974598
24CDC71.69528094
25ICK1.68045888
26PLK21.67505314
27NEK11.52113784
28TYRO31.51656191
29TTK1.50433181
30INSRR1.50009851
31GRK11.49753999
32MARK11.44789570
33STK38L1.41651938
34MKNK21.40859650
35OXSR11.40272639
36STK391.39371716
37MINK11.38648248
38MKNK11.33675140
39TLK11.33136183
40KSR11.32664903
41PLK31.29888894
42BRD41.28797978
43DAPK11.28217773
44PRKD31.27268038
45EPHA21.27098114
46PDGFRA1.24171463
47WNK41.22494015
48FGFR11.20822744
49BRSK21.13896237
50MAP3K101.12021784
51BCR1.10521795
52ERBB31.08956918
53PLK41.08629035
54PAK31.08101498
55PRPF4B1.06684607
56MAP3K91.05547245
57PASK1.03695776
58TAF11.03682046
59DAPK20.98359322
60MAP2K70.98145634
61CSNK1G20.97944917
62NTRK20.94967638
63PRKCG0.93351609
64PLK10.92043501
65MAP2K40.91563595
66UHMK10.90694521
67CSNK1G10.90003444
68BUB10.89442756
69CHEK20.88748403
70PDK40.88238998
71PDK30.88238998
72WEE10.85804536
73CDC42BPA0.83666681
74PRKCE0.82371251
75BMPR1B0.81960947
76CSNK1G30.80826214
77CAMK1G0.80764455
78ALK0.80389412
79TGFBR10.78251017
80PAK60.77911717
81CDK70.77578203
82RPS6KB20.77310182
83TAOK30.76821638
84STK380.76149294
85ERBB20.75732537
86CHEK10.75528805
87CSNK1A1L0.74676297
88CDK190.74451265
89CSNK1E0.72537985
90NEK20.70569567
91SIK30.70425064
92STK30.69404874
93DYRK20.68676940
94ADRBK10.68143464
95SRPK10.67880470
96CDK180.67769626
97GRK50.67596678
98TAOK20.67335974
99ERBB40.67312359
100YES10.66741636
101PTK2B0.63405847
102CDK30.63258511
103CDK150.62182049
104TESK10.61912681
105MTOR0.61672005
106AKT20.61447782
107VRK10.61278061
108CDK20.61207187
109SGK20.60759108
110AURKA0.60203317
111PHKG10.59196178
112PHKG20.59196178
113PKN10.58937493
114PRKCI0.58714840
115CDK10.58501049
116PAK40.57825701
117SIK20.57732147
118FER0.57677847
119CDK140.57453058
120DYRK1A0.57410230
121CCNB10.57168853
122ATM0.54873186
123PTK20.53011448
124RPS6KA20.52724060
125CAMK2A0.52618060
126WNK30.52359079
127CDK11A0.51186260
128NME10.50404317
129FGR0.49159670
130CSNK1D0.48711623
131NTRK10.48370430
132SGK4940.48320718
133SGK2230.48320718
134DYRK30.48237310
135CAMK2B0.47423141
136CDK60.46874918
137CAMK1D0.46616810
138STK110.46293355
139ATR0.45730881
140GSK3B0.43770136
141PRKDC0.43714326
142CAMK10.42824426
143CSNK1A10.40186902
144PRKG10.37670582
145PRKCZ0.37421513
146BRSK10.37381723
147PRKACA0.37007907
148CDK50.34523234
149PIK3CA0.33843172
150CAMK40.33421589
151VRK20.33007940
152PRKACB0.31333108
153EIF2AK20.29430573
154TIE10.28840841

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.16827458
2Hedgehog signaling pathway_Homo sapiens_hsa043402.80189473
3Hippo signaling pathway_Homo sapiens_hsa043902.56162208
4Nicotine addiction_Homo sapiens_hsa050332.55398329
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.34331544
6Butanoate metabolism_Homo sapiens_hsa006502.11178034
7Wnt signaling pathway_Homo sapiens_hsa043101.98010009
8Nitrogen metabolism_Homo sapiens_hsa009101.96067579
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94535013
10Axon guidance_Homo sapiens_hsa043601.90438676
11Long-term potentiation_Homo sapiens_hsa047201.87126457
12mRNA surveillance pathway_Homo sapiens_hsa030151.85703723
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.83409100
14Amphetamine addiction_Homo sapiens_hsa050311.82941924
15Basal transcription factors_Homo sapiens_hsa030221.80553515
16Homologous recombination_Homo sapiens_hsa034401.77387440
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.75609843
18Linoleic acid metabolism_Homo sapiens_hsa005911.70599349
19Melanogenesis_Homo sapiens_hsa049161.70343284
20Selenocompound metabolism_Homo sapiens_hsa004501.68300296
21Oocyte meiosis_Homo sapiens_hsa041141.68134111
22Circadian entrainment_Homo sapiens_hsa047131.65069339
23Oxidative phosphorylation_Homo sapiens_hsa001901.63732347
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63686417
25Protein export_Homo sapiens_hsa030601.62525449
26Tight junction_Homo sapiens_hsa045301.61672410
27Synaptic vesicle cycle_Homo sapiens_hsa047211.59723263
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58441023
29Spliceosome_Homo sapiens_hsa030401.57594519
30RNA transport_Homo sapiens_hsa030131.56912403
31Dopaminergic synapse_Homo sapiens_hsa047281.55736541
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54900451
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.53866013
34RNA polymerase_Homo sapiens_hsa030201.51245180
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.49760002
36Cell cycle_Homo sapiens_hsa041101.48879840
37Phototransduction_Homo sapiens_hsa047441.48585821
38Glutamatergic synapse_Homo sapiens_hsa047241.45686710
39GABAergic synapse_Homo sapiens_hsa047271.45449361
40Adherens junction_Homo sapiens_hsa045201.40572889
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.39452593
42Parkinsons disease_Homo sapiens_hsa050121.37374361
43Taste transduction_Homo sapiens_hsa047421.37310880
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34261994
45Tryptophan metabolism_Homo sapiens_hsa003801.32330768
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29106711
47Propanoate metabolism_Homo sapiens_hsa006401.28299766
48Mismatch repair_Homo sapiens_hsa034301.24451090
49Olfactory transduction_Homo sapiens_hsa047401.23718748
50Huntingtons disease_Homo sapiens_hsa050161.23307337
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22074368
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21042110
53Gap junction_Homo sapiens_hsa045401.20583946
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19326394
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19260511
56Ether lipid metabolism_Homo sapiens_hsa005651.19042884
57Colorectal cancer_Homo sapiens_hsa052101.18359937
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18152492
59Endometrial cancer_Homo sapiens_hsa052131.17273826
60Non-homologous end-joining_Homo sapiens_hsa034501.16454769
61Morphine addiction_Homo sapiens_hsa050321.15200369
62Long-term depression_Homo sapiens_hsa047301.14271515
63TGF-beta signaling pathway_Homo sapiens_hsa043501.10619228
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08813022
65Primary bile acid biosynthesis_Homo sapiens_hsa001201.07082611
66Estrogen signaling pathway_Homo sapiens_hsa049151.06768054
67Notch signaling pathway_Homo sapiens_hsa043301.01758855
68Insulin secretion_Homo sapiens_hsa049111.01284333
69Caffeine metabolism_Homo sapiens_hsa002321.00387482
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99666732
71One carbon pool by folate_Homo sapiens_hsa006700.99604098
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99215664
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98932424
74Melanoma_Homo sapiens_hsa052180.98471740
75Salivary secretion_Homo sapiens_hsa049700.96763728
76Oxytocin signaling pathway_Homo sapiens_hsa049210.95742074
77MicroRNAs in cancer_Homo sapiens_hsa052060.95368230
78ErbB signaling pathway_Homo sapiens_hsa040120.95122359
79mTOR signaling pathway_Homo sapiens_hsa041500.94482276
80Steroid biosynthesis_Homo sapiens_hsa001000.94426680
81Renin secretion_Homo sapiens_hsa049240.94239649
82Serotonergic synapse_Homo sapiens_hsa047260.93010689
83Cholinergic synapse_Homo sapiens_hsa047250.92239012
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.91814477
85Retinol metabolism_Homo sapiens_hsa008300.90340170
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.90078369
87Calcium signaling pathway_Homo sapiens_hsa040200.89803250
88GnRH signaling pathway_Homo sapiens_hsa049120.87878003
89Glioma_Homo sapiens_hsa052140.87604918
90Gastric acid secretion_Homo sapiens_hsa049710.87286199
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87049132
92Glucagon signaling pathway_Homo sapiens_hsa049220.86398161
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83698160
94Alzheimers disease_Homo sapiens_hsa050100.83634546
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83234629
96Rap1 signaling pathway_Homo sapiens_hsa040150.82249283
97ABC transporters_Homo sapiens_hsa020100.81544066
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80554945
99Proteoglycans in cancer_Homo sapiens_hsa052050.77127872
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76869418
101DNA replication_Homo sapiens_hsa030300.76188572
102Pathways in cancer_Homo sapiens_hsa052000.75387328
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74177226
104Cardiac muscle contraction_Homo sapiens_hsa042600.74025129
105Chemical carcinogenesis_Homo sapiens_hsa052040.73973767
106Regulation of autophagy_Homo sapiens_hsa041400.73881483
107Glycerolipid metabolism_Homo sapiens_hsa005610.73739834
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73670212
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73064657
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72331304
111Dilated cardiomyopathy_Homo sapiens_hsa054140.72180722
112Circadian rhythm_Homo sapiens_hsa047100.71864894
113cAMP signaling pathway_Homo sapiens_hsa040240.71581235
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69814204
115Type II diabetes mellitus_Homo sapiens_hsa049300.69251124
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66022496
117Biosynthesis of amino acids_Homo sapiens_hsa012300.65354492
118Peroxisome_Homo sapiens_hsa041460.65279551
119Ovarian steroidogenesis_Homo sapiens_hsa049130.65225692
120Bladder cancer_Homo sapiens_hsa052190.64645964
121Alcoholism_Homo sapiens_hsa050340.64501219
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63701920
123Cocaine addiction_Homo sapiens_hsa050300.62523586
124Vibrio cholerae infection_Homo sapiens_hsa051100.62168242
125Fanconi anemia pathway_Homo sapiens_hsa034600.61974374
126Dorso-ventral axis formation_Homo sapiens_hsa043200.61233131
127RNA degradation_Homo sapiens_hsa030180.61215901
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.61170610
129Lysine degradation_Homo sapiens_hsa003100.60921075
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60471679
131HTLV-I infection_Homo sapiens_hsa051660.60439003
132Base excision repair_Homo sapiens_hsa034100.60333540
133Nucleotide excision repair_Homo sapiens_hsa034200.60330142
134MAPK signaling pathway_Homo sapiens_hsa040100.59445810
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58097474
136Purine metabolism_Homo sapiens_hsa002300.57401425
137Collecting duct acid secretion_Homo sapiens_hsa049660.57350712
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57212051
139beta-Alanine metabolism_Homo sapiens_hsa004100.55467969
140Thyroid cancer_Homo sapiens_hsa052160.54563525
141Fat digestion and absorption_Homo sapiens_hsa049750.54390349
142Cysteine and methionine metabolism_Homo sapiens_hsa002700.53475657
143Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52880016
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51448957
145Prostate cancer_Homo sapiens_hsa052150.51210126
146Focal adhesion_Homo sapiens_hsa045100.51176512
147Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50675323
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48874984
149Ras signaling pathway_Homo sapiens_hsa040140.47357322
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47309733
151Metabolic pathways_Homo sapiens_hsa011000.46381504
152Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45873712
153Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45195394
154Pancreatic secretion_Homo sapiens_hsa049720.44710821

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