HUS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.74356053
2telomere maintenance via semi-conservative replication (GO:0032201)4.49120556
3nuclear pore complex assembly (GO:0051292)4.46475338
4DNA replication initiation (GO:0006270)4.41239756
5nuclear pore organization (GO:0006999)4.40986164
6DNA strand elongation involved in DNA replication (GO:0006271)4.35421173
7regulation of nuclear cell cycle DNA replication (GO:0033262)4.28708027
8DNA strand elongation (GO:0022616)4.23456508
9DNA unwinding involved in DNA replication (GO:0006268)4.17749941
10protein localization to kinetochore (GO:0034501)4.14525991
11telomere maintenance via recombination (GO:0000722)4.11801563
12kinetochore organization (GO:0051383)4.11647076
13mitotic recombination (GO:0006312)4.08822384
14platelet dense granule organization (GO:0060155)3.99527180
15CENP-A containing nucleosome assembly (GO:0034080)3.98017471
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.97698999
17NADH dehydrogenase complex assembly (GO:0010257)3.97698999
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.97698999
19DNA replication checkpoint (GO:0000076)3.94164041
20chromatin remodeling at centromere (GO:0031055)3.92838143
21IMP biosynthetic process (GO:0006188)3.92533520
22respiratory chain complex IV assembly (GO:0008535)3.87776548
23protein complex biogenesis (GO:0070271)3.86640097
24peptidyl-histidine modification (GO:0018202)3.84080398
25kinetochore assembly (GO:0051382)3.81677999
26telomere maintenance via telomere lengthening (GO:0010833)3.81077112
27mitochondrial respiratory chain complex assembly (GO:0033108)3.76607314
28somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.76244714
29somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.76244714
30isotype switching (GO:0045190)3.76244714
31pseudouridine synthesis (GO:0001522)3.73194962
32regulation of telomere maintenance via telomerase (GO:0032210)3.69732850
33attachment of spindle microtubules to kinetochore (GO:0008608)3.67132251
34DNA replication-independent nucleosome assembly (GO:0006336)3.62639182
35DNA replication-independent nucleosome organization (GO:0034724)3.62639182
36protein localization to chromosome, centromeric region (GO:0071459)3.60662416
37folic acid-containing compound biosynthetic process (GO:0009396)3.60036311
38mitotic sister chromatid cohesion (GO:0007064)3.57622312
39mitotic nuclear envelope disassembly (GO:0007077)3.56485071
40protein K6-linked ubiquitination (GO:0085020)3.55525181
41regulation of centriole replication (GO:0046599)3.53545688
42positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51457934
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.50477549
44nucleotide-excision repair, DNA gap filling (GO:0006297)3.49905927
45telomere maintenance (GO:0000723)3.46644123
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.46212196
47nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.44522354
48IMP metabolic process (GO:0046040)3.44161132
49cytochrome complex assembly (GO:0017004)3.42880101
50pore complex assembly (GO:0046931)3.41700315
51telomere organization (GO:0032200)3.41234993
52DNA double-strand break processing (GO:0000729)3.40998382
53mitotic metaphase plate congression (GO:0007080)3.40194419
54metaphase plate congression (GO:0051310)3.38588764
55regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.38495808
56cullin deneddylation (GO:0010388)3.38123949
57negative regulation of DNA-dependent DNA replication (GO:2000104)3.37380808
58ribosome assembly (GO:0042255)3.36867364
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36140168
60chaperone-mediated protein transport (GO:0072321)3.34437431
61protein deneddylation (GO:0000338)3.32465614
62signal peptide processing (GO:0006465)3.32206263
63nuclear envelope disassembly (GO:0051081)3.29954161
64membrane disassembly (GO:0030397)3.29954161
65mismatch repair (GO:0006298)3.29801167
66nucleobase biosynthetic process (GO:0046112)3.28632952
67DNA duplex unwinding (GO:0032508)3.28470224
68regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.27669852
69DNA geometric change (GO:0032392)3.27327230
70DNA synthesis involved in DNA repair (GO:0000731)3.26836202
71DNA replication-dependent nucleosome assembly (GO:0006335)3.26206352
72DNA replication-dependent nucleosome organization (GO:0034723)3.26206352
73regulation of cellular amino acid metabolic process (GO:0006521)3.25351534
74DNA deamination (GO:0045006)3.24348396
75establishment of chromosome localization (GO:0051303)3.22463716
76establishment of protein localization to mitochondrial membrane (GO:0090151)3.21651445
77histone exchange (GO:0043486)3.20363566
78sister chromatid segregation (GO:0000819)3.19958660
79DNA topological change (GO:0006265)3.19784593
80DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.19438079
81regulation of DNA endoreduplication (GO:0032875)3.19336072
82signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.17023370
83signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.17023370
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.17023370
85spindle assembly checkpoint (GO:0071173)3.16691290
86maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.16484199
87negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.15436525
88negative regulation of sister chromatid segregation (GO:0033046)3.15436525
89negative regulation of mitotic sister chromatid separation (GO:2000816)3.15436525
90negative regulation of mitotic sister chromatid segregation (GO:0033048)3.15436525
91negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.15223862
92negative regulation of ligase activity (GO:0051352)3.15223862
93spindle checkpoint (GO:0031577)3.13784359
94positive regulation of DNA-dependent DNA replication (GO:2000105)3.13455098
95maturation of 5.8S rRNA (GO:0000460)3.12657084
96negative regulation of chromosome segregation (GO:0051985)3.12099581
97regulation of centrosome cycle (GO:0046605)3.11177947
98negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11121261
99intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.10561354
100signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.10561354
101mitotic spindle assembly checkpoint (GO:0007094)3.06733114
102regulation of helicase activity (GO:0051095)3.06114136
103mitotic sister chromatid segregation (GO:0000070)3.06070615
104protein K11-linked deubiquitination (GO:0035871)3.04565323
105double-strand break repair via nonhomologous end joining (GO:0006303)3.03912154
106non-recombinational repair (GO:0000726)3.03912154
107translesion synthesis (GO:0019985)3.02793954
108regulation of spindle organization (GO:0090224)3.02462342
109regulation of histone H3-K9 methylation (GO:0051570)3.02247373
110water-soluble vitamin biosynthetic process (GO:0042364)3.02228674
111DNA strand renaturation (GO:0000733)3.01819089
112replication fork processing (GO:0031297)3.01606730
113signal transduction involved in cell cycle checkpoint (GO:0072395)3.01391652
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.00504637
115signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00451387
116signal transduction involved in DNA damage checkpoint (GO:0072422)3.00451387
117somatic hypermutation of immunoglobulin genes (GO:0016446)3.00398096
118somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00398096
119regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99980280
120RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.99949870
121histone mRNA metabolic process (GO:0008334)2.99145746
122preassembly of GPI anchor in ER membrane (GO:0016254)2.98985381
123mitotic spindle checkpoint (GO:0071174)2.97515020
124regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.96997036
125positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95453943
126meiotic chromosome segregation (GO:0045132)2.94332900
127regulation of DNA-dependent DNA replication (GO:0090329)2.94330061
128chromatin assembly or disassembly (GO:0006333)2.93247486
129single strand break repair (GO:0000012)2.93092936
130regulation of double-strand break repair via homologous recombination (GO:0010569)2.92594662
131mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.91698053
132regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.91531579
133mitotic chromosome condensation (GO:0007076)2.91470716
134regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.91411955
135regulation of mitotic spindle checkpoint (GO:1903504)2.91411955
136protein localization to chromosome (GO:0034502)2.91090458
137protein neddylation (GO:0045116)2.89926915
138regulation of meiosis I (GO:0060631)2.89814748
139deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.88718372
140regulation of mitotic sister chromatid separation (GO:0010965)2.88221243
141regulation of mitotic sister chromatid segregation (GO:0033047)2.88221243
142regulation of sister chromatid segregation (GO:0033045)2.88221243
143mannosylation (GO:0097502)2.88063506
144viral mRNA export from host cell nucleus (GO:0046784)2.87511886
145purine nucleobase biosynthetic process (GO:0009113)2.87352110
146regulation of chromosome segregation (GO:0051983)2.85914134
147regulation of hexokinase activity (GO:1903299)2.84733983
148regulation of glucokinase activity (GO:0033131)2.84733983
149positive regulation of ligase activity (GO:0051351)2.84721803
150protein-cofactor linkage (GO:0018065)2.83785469
151mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.82871231
152* DNA replication (GO:0006260)2.82619787
153ATP-dependent chromatin remodeling (GO:0043044)2.82197500
154dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.81990994
155replicative senescence (GO:0090399)2.81905352
156L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81530341
157acrosome assembly (GO:0001675)2.80121492
158tRNA processing (GO:0008033)2.79871116
159branched-chain amino acid catabolic process (GO:0009083)2.79760029
160dosage compensation (GO:0007549)2.78982831
161regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.77496739
162somatic diversification of immunoglobulins (GO:0016445)2.76935703
163somatic recombination of immunoglobulin gene segments (GO:0016447)2.76546316
164* double-strand break repair via homologous recombination (GO:0000724)2.76218168
165histone mRNA catabolic process (GO:0071044)2.76169202
166* recombinational repair (GO:0000725)2.75077821
167regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.73835974
168organelle disassembly (GO:1903008)2.71879818
169indole-containing compound catabolic process (GO:0042436)2.70386266
170indolalkylamine catabolic process (GO:0046218)2.70386266
171tryptophan catabolic process (GO:0006569)2.70386266
172mitochondrial RNA metabolic process (GO:0000959)2.70064769
173mitochondrial DNA replication (GO:0006264)2.67866831
174protein prenylation (GO:0018342)2.65578825
175prenylation (GO:0097354)2.65578825
176protein K11-linked ubiquitination (GO:0070979)2.63444493
177anterograde synaptic vesicle transport (GO:0048490)2.63037923
178indolalkylamine metabolic process (GO:0006586)2.62100754
179DNA catabolic process, exonucleolytic (GO:0000738)2.61575124
180establishment of integrated proviral latency (GO:0075713)2.60597385
181ribonucleoprotein complex disassembly (GO:0032988)2.60081326
182regulation of acyl-CoA biosynthetic process (GO:0050812)2.59923044
183C-terminal protein lipidation (GO:0006501)2.59038868
184DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.57200027
185negative regulation of protein ubiquitination (GO:0031397)2.56819662

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.82735917
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.55131285
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.61352715
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.55474018
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.95847543
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.81864539
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.64051935
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.51072692
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48531721
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.43183025
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.32476777
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.29923224
13VDR_22108803_ChIP-Seq_LS180_Human2.24633623
14ZNF274_21170338_ChIP-Seq_K562_Hela2.23922025
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22492046
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20168959
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.18017864
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.17189772
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16720173
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15853026
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.14644217
22AR_21909140_ChIP-Seq_LNCAP_Human2.13582266
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06947881
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06905793
25E2F7_22180533_ChIP-Seq_HELA_Human10.9579412
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.95015147
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94370624
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91456202
29* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90554801
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90018410
31VDR_23849224_ChIP-Seq_CD4+_Human1.89710663
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88211638
33* FOXP3_21729870_ChIP-Seq_TREG_Human1.87099374
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85320864
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84264369
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79111162
37ELK1_19687146_ChIP-ChIP_HELA_Human1.76405162
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74817206
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73890318
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73844048
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73807518
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72017264
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71544813
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71173781
45XRN2_22483619_ChIP-Seq_HELA_Human1.71093225
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68728266
47* ETS1_20019798_ChIP-Seq_JURKAT_Human1.63832344
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61531996
49* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59448991
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56890259
51P300_19829295_ChIP-Seq_ESCs_Human1.55156695
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52464472
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.52056481
54CIITA_25753668_ChIP-Seq_RAJI_Human1.51445114
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51122035
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.51070264
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48783284
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47411516
59IGF1R_20145208_ChIP-Seq_DFB_Human1.47017082
60FUS_26573619_Chip-Seq_HEK293_Human1.43925677
61TTF2_22483619_ChIP-Seq_HELA_Human1.43429814
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.41869216
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40829388
64MYC_22102868_ChIP-Seq_BL_Human1.39902550
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39618119
66DCP1A_22483619_ChIP-Seq_HELA_Human1.39540052
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37840973
68* GABP_19822575_ChIP-Seq_HepG2_Human1.34479014
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34460864
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.32352629
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30239476
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28943051
73SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28804571
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28146639
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27695792
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.27460457
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26612723
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26072479
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25908853
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.25493893
81KDM5A_27292631_Chip-Seq_BREAST_Human1.24979511
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23649856
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22219359
84* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.21072692
85* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20753154
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20512295
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20000838
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18094300
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16560830
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16204595
91ER_23166858_ChIP-Seq_MCF-7_Human1.13879737
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13570927
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.11731268
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11276014
95IRF1_19129219_ChIP-ChIP_H3396_Human1.11074086
96SCL_19346495_ChIP-Seq_HPC-7_Human1.09914988
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09464030
98SPI1_23547873_ChIP-Seq_NB4_Human1.08443826
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08079551
100CDX2_22108803_ChIP-Seq_LS180_Human1.07871761
101YY1_21170310_ChIP-Seq_MESCs_Mouse1.06313740
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06297303
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05673513
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04976862
105TP53_22573176_ChIP-Seq_HFKS_Human1.04792713
106SRF_21415370_ChIP-Seq_HL-1_Mouse1.04321088
107TAF15_26573619_Chip-Seq_HEK293_Human1.03373722
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02523974
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02467630
110NANOG_19829295_ChIP-Seq_ESCs_Human1.01070293
111SOX2_19829295_ChIP-Seq_ESCs_Human1.01070293
112ELK1_22589737_ChIP-Seq_MCF10A_Human1.00918593
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00561199
114* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99265689
115BCAT_22108803_ChIP-Seq_LS180_Human0.98763664
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98578260
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98527504
118CBP_20019798_ChIP-Seq_JUKART_Human0.98527504
119PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96492088
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94920500
121* TFEB_21752829_ChIP-Seq_HELA_Human0.94664191
122* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93162048
123GATA3_26560356_Chip-Seq_TH2_Human0.93009515
124NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91812737
125SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90769229
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90551140
127MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90241825
128GATA1_22025678_ChIP-Seq_K562_Human0.89251717
129TCF4_22108803_ChIP-Seq_LS180_Human0.89181196
130STAT3_18555785_Chip-Seq_ESCs_Mouse0.89152343
131ELF5_23300383_ChIP-Seq_T47D_Human0.88670493
132CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88194954
133MYB_26560356_Chip-Seq_TH2_Human0.87930518
134EWS_26573619_Chip-Seq_HEK293_Human0.87632352
135FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.87570729
136P300_18555785_Chip-Seq_ESCs_Mouse0.87160666
137* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86786514
138SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86774784
139AR_20517297_ChIP-Seq_VCAP_Human0.86716696
140CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86478656
141MYB_26560356_Chip-Seq_TH1_Human0.85558726
142MYC_18940864_ChIP-ChIP_HL60_Human0.83092497
143STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.80357369
144CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80348175
145NANOG_21062744_ChIP-ChIP_HESCs_Human0.79426421
146BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.77442940
147IRF8_21731497_ChIP-ChIP_J774_Mouse0.76728475
148KLF4_18555785_ChIP-Seq_MESCs_Mouse0.76374919
149STAT3_1855785_ChIP-Seq_MESCs_Mouse0.76191316
150DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75831098
151POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73412264
152KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.73171789
153DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72355406
154ESR1_15608294_ChIP-ChIP_MCF-7_Human0.72032438

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010094_abnormal_chromosome_stability4.42317864
2MP0003693_abnormal_embryo_hatching4.20441115
3* MP0003111_abnormal_nucleus_morphology4.06433199
4MP0008057_abnormal_DNA_replication3.79247036
5MP0003195_calcinosis3.37376361
6MP0004957_abnormal_blastocyst_morpholog3.34044536
7* MP0003077_abnormal_cell_cycle3.33225944
8MP0008058_abnormal_DNA_repair3.31007479
9MP0002396_abnormal_hematopoietic_system3.14921297
10MP0008007_abnormal_cellular_replicative2.69086243
11MP0002254_reproductive_system_inflammat2.66566888
12MP0003806_abnormal_nucleotide_metabolis2.59402134
13MP0006292_abnormal_olfactory_placode2.38707284
14MP0008932_abnormal_embryonic_tissue2.17446150
15* MP0003186_abnormal_redox_activity2.12886655
16MP0005408_hypopigmentation2.09707313
17MP0005084_abnormal_gallbladder_morpholo2.09110119
18MP0008877_abnormal_DNA_methylation2.07454910
19MP0003646_muscle_fatigue1.72640271
20MP0000490_abnormal_crypts_of1.70800541
21MP0006072_abnormal_retinal_apoptosis1.67128517
22* MP0000350_abnormal_cell_proliferation1.66297724
23MP0004808_abnormal_hematopoietic_stem1.62256794
24* MP0001672_abnormal_embryogenesis/_devel1.60633863
25* MP0005380_embryogenesis_phenotype1.60633863
26MP0001293_anophthalmia1.58915339
27MP0003121_genomic_imprinting1.58364480
28MP0002837_dystrophic_cardiac_calcinosis1.58188655
29MP0003786_premature_aging1.50647822
30MP0010030_abnormal_orbit_morphology1.50566769
31* MP0003984_embryonic_growth_retardation1.46253587
32* MP0001730_embryonic_growth_arrest1.45428151
33MP0000427_abnormal_hair_cycle1.43741651
34MP0003123_paternal_imprinting1.42540492
35MP0010352_gastrointestinal_tract_polyps1.41577236
36* MP0002088_abnormal_embryonic_growth/wei1.40889803
37MP0000566_synostosis1.40718711
38MP0003890_abnormal_embryonic-extraembry1.38442071
39* MP0002086_abnormal_extraembryonic_tissu1.38389946
40MP0004147_increased_porphyrin_level1.37213356
41* MP0002085_abnormal_embryonic_tissue1.34790129
42MP0003763_abnormal_thymus_physiology1.34422591
43* MP0001697_abnormal_embryo_size1.33412506
44MP0009697_abnormal_copulation1.31373230
45MP0002398_abnormal_bone_marrow1.30061877
46MP0000015_abnormal_ear_pigmentation1.29254030
47MP0006054_spinal_hemorrhage1.28703867
48MP0006036_abnormal_mitochondrial_physio1.27748083
49MP0004215_abnormal_myocardial_fiber1.25525741
50MP0009840_abnormal_foam_cell1.25233185
51MP0009764_decreased_sensitivity_to1.25161459
52MP0001188_hyperpigmentation1.24370877
53MP0003718_maternal_effect1.22232403
54MP0006035_abnormal_mitochondrial_morpho1.21606583
55* MP0000313_abnormal_cell_death1.21457138
56MP0002163_abnormal_gland_morphology1.21407602
57MP0010307_abnormal_tumor_latency1.20562524
58MP0004197_abnormal_fetal_growth/weight/1.19675793
59* MP0002084_abnormal_developmental_patter1.19583655
60* MP0002080_prenatal_lethality1.19553963
61MP0005671_abnormal_response_to1.19212515
62MP0000703_abnormal_thymus_morphology1.18007687
63MP0002160_abnormal_reproductive_system1.16059860
64MP0002938_white_spotting1.15073377
65MP0001764_abnormal_homeostasis1.14758399
66MP0003950_abnormal_plasma_membrane1.14620215
67MP0003567_abnormal_fetal_cardiomyocyte1.13979957
68MP0002019_abnormal_tumor_incidence1.13494902
69MP0001119_abnormal_female_reproductive1.13356807
70MP0002132_abnormal_respiratory_system1.13319943
71MP0000647_abnormal_sebaceous_gland1.10909859
72MP0002148_abnormal_hypersensitivity_rea1.10707376
73MP0002210_abnormal_sex_determination1.09852888
74MP0002638_abnormal_pupillary_reflex1.09824243
75MP0002722_abnormal_immune_system1.09330708
76MP0003136_yellow_coat_color1.09190867
77MP0005253_abnormal_eye_physiology1.08268172
78MP0005167_abnormal_blood-brain_barrier1.07778770
79MP0005174_abnormal_tail_pigmentation1.07758105
80MP0000358_abnormal_cell_content/1.07135194
81MP0002095_abnormal_skin_pigmentation1.06526229
82MP0001324_abnormal_eye_pigmentation1.06319208
83MP0000689_abnormal_spleen_morphology1.05948594
84MP0003941_abnormal_skin_development1.05732812
85MP0001919_abnormal_reproductive_system1.05346180
86MP0001186_pigmentation_phenotype1.05255256
87MP0002075_abnormal_coat/hair_pigmentati1.04327731
88MP0003172_abnormal_lysosome_physiology1.03435349
89MP0009785_altered_susceptibility_to1.02098530
90MP0003787_abnormal_imprinting1.01760838
91MP0005395_other_phenotype1.01102119
92MP0000383_abnormal_hair_follicle0.99871451
93MP0005085_abnormal_gallbladder_physiolo0.99480805
94MP0005310_abnormal_salivary_gland0.97620378
95* MP0003937_abnormal_limbs/digits/tail_de0.97374429
96MP0001286_abnormal_eye_development0.94276219
97MP0000569_abnormal_digit_pigmentation0.93486595
98* MP0002429_abnormal_blood_cell0.92711403
99MP0008789_abnormal_olfactory_epithelium0.92543715
100MP0005389_reproductive_system_phenotype0.92181116
101MP0005397_hematopoietic_system_phenotyp0.92085374
102MP0001545_abnormal_hematopoietic_system0.92085374
103MP0002090_abnormal_vision0.91219392
104MP0002009_preneoplasia0.91064869
105MP0000371_diluted_coat_color0.88681415
106MP0008875_abnormal_xenobiotic_pharmacok0.88327988
107MP0000716_abnormal_immune_system0.88319070
108MP0000516_abnormal_urinary_system0.87609960
109MP0005367_renal/urinary_system_phenotyp0.87609960
110MP0001145_abnormal_male_reproductive0.86712008
111MP0005332_abnormal_amino_acid0.86538856
112MP0002138_abnormal_hepatobiliary_system0.86098552
113MP0002876_abnormal_thyroid_physiology0.86077887
114MP0003191_abnormal_cellular_cholesterol0.86060786
115MP0002877_abnormal_melanocyte_morpholog0.85882180
116MP0010386_abnormal_urinary_bladder0.85692359
117MP0002102_abnormal_ear_morphology0.85331652
118MP0008995_early_reproductive_senescence0.85203561
119MP0002420_abnormal_adaptive_immunity0.85062781
120MP0001915_intracranial_hemorrhage0.84662691
121MP0003943_abnormal_hepatobiliary_system0.83965949
122MP0000653_abnormal_sex_gland0.83650911
123MP0005551_abnormal_eye_electrophysiolog0.83122856
124MP0001819_abnormal_immune_cell0.82853542
125MP0002092_abnormal_eye_morphology0.82798962
126MP0004264_abnormal_extraembryonic_tissu0.82220265
127MP0005365_abnormal_bile_salt0.81758367
128MP0001800_abnormal_humoral_immune0.81206885
129MP0009703_decreased_birth_body0.80669171
130MP0001835_abnormal_antigen_presentation0.80659174
131MP0005075_abnormal_melanosome_morpholog0.79312618
132MP0002452_abnormal_antigen_presenting0.78586356
133MP0001929_abnormal_gametogenesis0.77993131
134MP0000372_irregular_coat_pigmentation0.76958345
135MP0009333_abnormal_splenocyte_physiolog0.75017956
136MP0008872_abnormal_physiological_respon0.74468794
137MP0002332_abnormal_exercise_endurance0.74363886
138MP0002139_abnormal_hepatobiliary_system0.74242828
139MP0005647_abnormal_sex_gland0.74071798
140MP0005266_abnormal_metabolism0.73620976
141MP0005330_cardiomyopathy0.72653432
142MP0005171_absent_coat_pigmentation0.72187342
143MP0000432_abnormal_head_morphology0.72113854
144MP0002653_abnormal_ependyma_morphology0.71255731
145MP0002249_abnormal_larynx_morphology0.70600270
146MP0004133_heterotaxia0.69681221
147MP0002697_abnormal_eye_size0.69195485
148MP0005379_endocrine/exocrine_gland_phen0.68641687
149MP0002177_abnormal_outer_ear0.67367245
150MP0010678_abnormal_skin_adnexa0.66167413
151MP0001853_heart_inflammation0.64242779
152MP0002127_abnormal_cardiovascular_syste0.62902280
153MP0004484_altered_response_of0.60546801
154MP0003828_pulmonary_edema0.59921984
155MP0004084_abnormal_cardiac_muscle0.59138663
156MP0003724_increased_susceptibility_to0.59026840
157MP0003868_abnormal_feces_composition0.58168495
158MP0003221_abnormal_cardiomyocyte_apopto0.57842925
159MP0001666_abnormal_nutrient_absorption0.56049755

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.82602040
2Chromsome breakage (HP:0040012)5.77943285
3Abnormality of chromosome stability (HP:0003220)4.23497750
4Birth length less than 3rd percentile (HP:0003561)4.20662873
5Meckel diverticulum (HP:0002245)3.73561802
6Abnormality of the preputium (HP:0100587)3.71972549
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.62521093
8Abnormality of the ileum (HP:0001549)3.62195976
9Acute necrotizing encephalopathy (HP:0006965)3.60701610
10Albinism (HP:0001022)3.60685838
11Abnormality of the renal collecting system (HP:0004742)3.57825913
12Increased CSF lactate (HP:0002490)3.56553511
13Duplicated collecting system (HP:0000081)3.53569962
14Ectopic kidney (HP:0000086)3.49139704
15Mitochondrial inheritance (HP:0001427)3.37188052
16Progressive macrocephaly (HP:0004481)3.23332643
17Acute encephalopathy (HP:0006846)3.22190241
18Reticulocytopenia (HP:0001896)3.17757182
19Methylmalonic acidemia (HP:0002912)3.17550270
20Small intestinal stenosis (HP:0012848)3.11668997
21Duodenal stenosis (HP:0100867)3.11668997
22Myelodysplasia (HP:0002863)3.07349487
23Abnormal mitochondria in muscle tissue (HP:0008316)3.06112638
24Aplasia/Hypoplasia of the fovea (HP:0008060)2.97228766
25Hypoplasia of the fovea (HP:0007750)2.97228766
26Clubbing of toes (HP:0100760)2.96548880
27Medulloblastoma (HP:0002885)2.93226435
28Volvulus (HP:0002580)2.88033199
29Abnormality of DNA repair (HP:0003254)2.85682630
30Increased hepatocellular lipid droplets (HP:0006565)2.82330866
313-Methylglutaconic aciduria (HP:0003535)2.81209848
32Abnormality of the carotid arteries (HP:0005344)2.79174964
33Aplastic anemia (HP:0001915)2.75190769
34Bone marrow hypocellularity (HP:0005528)2.73743676
35Hepatocellular necrosis (HP:0001404)2.72032478
36Pancreatic fibrosis (HP:0100732)2.71045253
37Patellar aplasia (HP:0006443)2.69608128
38Methylmalonic aciduria (HP:0012120)2.68009407
39Increased serum lactate (HP:0002151)2.65978653
40Nephroblastoma (Wilms tumor) (HP:0002667)2.62007610
41Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.60649491
42Abnormal protein N-linked glycosylation (HP:0012347)2.60649491
43Abnormal protein glycosylation (HP:0012346)2.60649491
44Abnormal glycosylation (HP:0012345)2.60649491
45Breast hypoplasia (HP:0003187)2.60033151
46Lipid accumulation in hepatocytes (HP:0006561)2.57963390
4711 pairs of ribs (HP:0000878)2.57275328
48Cerebral edema (HP:0002181)2.57142542
49Abnormality of the fovea (HP:0000493)2.56400866
50Abnormality of the duodenum (HP:0002246)2.56267725
51Hepatic necrosis (HP:0002605)2.54961597
52Molar tooth sign on MRI (HP:0002419)2.53398466
53Abnormality of midbrain morphology (HP:0002418)2.53398466
54Renal Fanconi syndrome (HP:0001994)2.51179447
55Medial flaring of the eyebrow (HP:0010747)2.49871328
56Selective tooth agenesis (HP:0001592)2.43727044
57True hermaphroditism (HP:0010459)2.43039449
58Abnormality of methionine metabolism (HP:0010901)2.41413847
59Aplasia/Hypoplasia of the patella (HP:0006498)2.40485396
60Sloping forehead (HP:0000340)2.40112702
61Oral leukoplakia (HP:0002745)2.40097694
62Embryonal renal neoplasm (HP:0011794)2.38650287
63Absent thumb (HP:0009777)2.36012351
64Chronic hepatic failure (HP:0100626)2.34423201
65Acute myeloid leukemia (HP:0004808)2.33430400
66Degeneration of anterior horn cells (HP:0002398)2.33139976
67Abnormality of the anterior horn cell (HP:0006802)2.33139976
68Deep philtrum (HP:0002002)2.32760787
69Increased nuchal translucency (HP:0010880)2.32432345
70Hyperalaninemia (HP:0003348)2.32399745
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32399745
72Abnormality of alanine metabolism (HP:0010916)2.32399745
73Abnormality of the renal cortex (HP:0011035)2.31513932
74IgM deficiency (HP:0002850)2.30267051
75Neoplasm of the adrenal cortex (HP:0100641)2.27879594
76Absent radius (HP:0003974)2.27815233
77Abnormal number of incisors (HP:0011064)2.25455773
78Exertional dyspnea (HP:0002875)2.24624044
79Lactic acidosis (HP:0003128)2.24424543
80Supernumerary spleens (HP:0009799)2.24042382
81High pitched voice (HP:0001620)2.23065233
82Abnormal lung lobation (HP:0002101)2.21898163
83Progressive inability to walk (HP:0002505)2.19199895
84Respiratory failure (HP:0002878)2.18891170
85Fair hair (HP:0002286)2.18049809
86Impulsivity (HP:0100710)2.15980411
87Rough bone trabeculation (HP:0100670)2.14997929
88Stomatitis (HP:0010280)2.14721369
89Absent forearm bone (HP:0003953)2.13714957
90Aplasia involving forearm bones (HP:0009822)2.13714957
91Patchy hypopigmentation of hair (HP:0011365)2.12785744
92Abnormality of renal resorption (HP:0011038)2.12728499
93Bile duct proliferation (HP:0001408)2.12624934
94Abnormal biliary tract physiology (HP:0012439)2.12624934
95Renal cortical cysts (HP:0000803)2.07015864
96High anterior hairline (HP:0009890)2.06113122
97Ependymoma (HP:0002888)2.05878170
98Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05696293
99Abnormality of vitamin B metabolism (HP:0004340)2.05078870
100Lethargy (HP:0001254)2.04206318
101Abnormality of the renal medulla (HP:0100957)2.04178642
102Congenital primary aphakia (HP:0007707)2.03826354
103Congenital, generalized hypertrichosis (HP:0004540)2.03468449
104Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03203670
105Rhabdomyosarcoma (HP:0002859)2.02962897
106Prostate neoplasm (HP:0100787)2.02525417
107Prominent nose (HP:0000448)2.02095319
108Triphalangeal thumb (HP:0001199)2.01766890
109Carpal bone hypoplasia (HP:0001498)2.00440032
110Pendular nystagmus (HP:0012043)1.99751940
111Premature graying of hair (HP:0002216)1.99422446
112Nephronophthisis (HP:0000090)1.98615455
113Hypothermia (HP:0002045)1.98608334
114Tracheoesophageal fistula (HP:0002575)1.96782633
115Reduced antithrombin III activity (HP:0001976)1.93537506
116Horseshoe kidney (HP:0000085)1.93262819
117Agnosia (HP:0010524)1.91026211
118Thyroiditis (HP:0100646)1.90996036
119Colon cancer (HP:0003003)1.89896763
120White forelock (HP:0002211)1.89210119
121Short thumb (HP:0009778)1.89051166
122Glioma (HP:0009733)1.88792416
123Tubular atrophy (HP:0000092)1.88468662
124Lymphoma (HP:0002665)1.86981710
125Acute lymphatic leukemia (HP:0006721)1.86728338
126Neoplasm of the adrenal gland (HP:0100631)1.85379044
127Abnormality of pyrimidine metabolism (HP:0004353)1.84615361
128Optic nerve coloboma (HP:0000588)1.82112017
129Disproportionate short-trunk short stature (HP:0003521)1.81922850
130Abnormality of the vitamin B12 metabolism (HP:0004341)1.81773691
131Intestinal atresia (HP:0011100)1.80678487
132Nephrogenic diabetes insipidus (HP:0009806)1.80348584
133Type I transferrin isoform profile (HP:0003642)1.80321216
134Small hand (HP:0200055)1.79869331
135Missing ribs (HP:0000921)1.78009842
136Arteriovenous malformation (HP:0100026)1.77734701
137Enlarged kidneys (HP:0000105)1.77396348
138Proximal placement of thumb (HP:0009623)1.74911887
139Leukopenia (HP:0001882)1.74247932
140Ureteral duplication (HP:0000073)1.74082448
141Embryonal neoplasm (HP:0002898)1.73909771
142Abnormality of serum amino acid levels (HP:0003112)1.73329701
143Abnormality of the intervertebral disk (HP:0005108)1.73270375
144Generalized hypopigmentation (HP:0007513)1.73152194
145Gait imbalance (HP:0002141)1.72375693
146Long eyelashes (HP:0000527)1.71892874
147Inability to walk (HP:0002540)1.71486767
148Deviation of the thumb (HP:0009603)1.71122018
149Cafe-au-lait spot (HP:0000957)1.70739327
150Abnormality of macular pigmentation (HP:0008002)1.70294076
151Tubulointerstitial nephritis (HP:0001970)1.69974728
152Hyperglycinemia (HP:0002154)1.69756719
153Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.69268903
154Short middle phalanx of the 5th finger (HP:0004220)1.69244845
155Abnormality of urine glucose concentration (HP:0011016)1.69002646
156Glycosuria (HP:0003076)1.69002646
157Neuroendocrine neoplasm (HP:0100634)1.68137064
158Abnormal trabecular bone morphology (HP:0100671)1.68087798
159Exercise intolerance (HP:0003546)1.68027639
160Optic disc pallor (HP:0000543)1.67898038
161Abnormality of the fingertips (HP:0001211)1.66685723
162Pancreatic cysts (HP:0001737)1.66474912
163Pancytopenia (HP:0001876)1.66319711
164Gonadotropin excess (HP:0000837)1.66238619
165CNS demyelination (HP:0007305)1.66039125
166Aplasia/Hypoplasia of the macula (HP:0008059)1.65934004
167Gastrointestinal atresia (HP:0002589)1.64607612
168Amaurosis fugax (HP:0100576)1.64333729
169Abnormality of the heme biosynthetic pathway (HP:0010472)1.64009718
170Neoplasm of striated muscle (HP:0009728)1.63874834
171Neoplasm of the peripheral nervous system (HP:0100007)1.62944378
172Abnormality of the fetal cardiovascular system (HP:0010948)1.62696436
173Abnormal umbilical cord blood vessels (HP:0011403)1.62696436
174Single umbilical artery (HP:0001195)1.62696436
175Neoplasm of the oral cavity (HP:0100649)1.61360904
176Diastasis recti (HP:0001540)1.61075165
177Duplication of thumb phalanx (HP:0009942)1.57218535
178Oligohydramnios (HP:0001562)1.57189099
179Aplasia/Hypoplasia of the sternum (HP:0006714)1.56804702
180Cellular immunodeficiency (HP:0005374)1.55695756
181Atresia of the external auditory canal (HP:0000413)1.55631232
182Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.54630489
183Short 4th metacarpal (HP:0010044)1.54630489
184Slender long bone (HP:0003100)1.54302265
185Abnormality of the incisor (HP:0000676)1.50284229

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.29114640
2MST43.61539436
3TRIM283.60386166
4FRK3.16291509
5SRPK13.02739674
6PDK23.01142223
7TTK2.91965180
8WEE12.90764663
9BUB12.89374049
10ZAK2.82690478
11MKNK22.50340518
12MKNK12.46155276
13STK162.38655857
14CDK122.35984548
15PBK2.24538493
16TAOK32.22458901
17NEK22.21707465
18IRAK42.17026764
19ATR2.04023905
20PLK42.03702630
21MAP4K21.92975478
22LATS11.84140133
23INSRR1.83722571
24ADRBK21.78537287
25TSSK61.76904553
26VRK21.76642550
27PLK11.73688684
28BRD41.69101669
29PASK1.61637334
30BRSK21.60807989
31EIF2AK31.60290998
32CDK71.59197502
33EIF2AK11.58017947
34STK391.56306609
35PLK31.54376643
36CHEK21.52183239
37SIK31.47047462
38CLK11.43838026
39VRK11.43285713
40TIE11.43005124
41GRK11.39791881
42AURKB1.39512807
43STK41.28991848
44TXK1.23897417
45AKT31.23676151
46ACVR1B1.23641130
47STK101.23581566
48STK31.23501748
49OXSR11.22953732
50NEK11.19363073
51CHEK11.18043501
52RPS6KB21.17772229
53MUSK1.13507505
54DYRK31.11787127
55CDK41.11262342
56ATM1.11144745
57TAF11.10005209
58NUAK11.05093885
59KDR1.01374549
60YES11.01325666
61MAP3K120.97891812
62TGFBR10.94534523
63NLK0.93238969
64CDK60.92196929
65MAP3K40.91860587
66EPHA20.89727547
67BCR0.87186584
68CAMKK20.86844314
69PIK3CG0.86624122
70TNIK0.86448001
71PIM10.86232837
72CDK80.85882789
73PLK20.84440978
74FGFR30.83945052
75BMPR20.83357180
76CCNB10.83042848
77ZAP700.82816681
78FER0.82676691
79MAP3K80.81823601
80PAK30.79829638
81CDK20.79811094
82EIF2AK20.76547136
83TLK10.75762540
84CSNK1G10.75730853
85GRK70.74656014
86BMPR1B0.73656974
87ERBB40.73175634
88CDK90.72966176
89ALK0.72134896
90JAK30.71239422
91NME10.70700607
92CDK10.69798937
93AURKA0.67676951
94MAP2K70.66776483
95TEC0.66604617
96IRAK30.66345775
97ERBB30.66138088
98FLT30.65535390
99EEF2K0.64340293
100RPS6KA40.60359080
101STK38L0.59500428
102CDK30.58900184
103MAP3K140.58490432
104MAP4K10.56479488
105PINK10.53052697
106IKBKB0.52872052
107OBSCN0.52798043
108WNK30.51111030
109BTK0.50348271
110AKT10.49459082
111KIT0.48952872
112WNK40.48137487
113ADRBK10.47646714
114AKT20.47494706
115PRKCE0.46365433
116TGFBR20.46314709
117NEK90.46244520
118SGK20.46182843
119PTK2B0.46004991
120MATK0.45668057
121TESK20.45201749
122BRSK10.44595476
123CSNK2A10.44296225
124CSNK1G30.43750862
125MELK0.42833944
126PAK40.42727103
127MAPK140.41098555
128PHKG20.40688136
129PHKG10.40688136
130CSNK1G20.40081541
131IRAK10.38636588
132CSNK1A1L0.38499838
133NME20.37355953
134MARK30.35312249
135CSNK2A20.34570092
136NEK60.33824215
137TYK20.33578488
138BLK0.33552479
139LYN0.33061493
140SGK30.33047165
141MYLK0.33025355
142MTOR0.32869293
143MAPK10.31915985
144TRPM70.31548729
145LIMK10.30820489
146ABL10.30048837
147RPS6KA50.29173979
148PNCK0.26492015
149DMPK0.26209743
150IGF1R0.25479004

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.91212267
2Mismatch repair_Homo sapiens_hsa034304.12731780
3Fanconi anemia pathway_Homo sapiens_hsa034603.27923155
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.23423725
5Homologous recombination_Homo sapiens_hsa034403.21750673
6Cell cycle_Homo sapiens_hsa041102.95683161
7Non-homologous end-joining_Homo sapiens_hsa034502.91763682
8Base excision repair_Homo sapiens_hsa034102.84904060
9Spliceosome_Homo sapiens_hsa030402.79408329
10One carbon pool by folate_Homo sapiens_hsa006702.76621332
11Nucleotide excision repair_Homo sapiens_hsa034202.74199403
12RNA polymerase_Homo sapiens_hsa030202.70099604
13RNA transport_Homo sapiens_hsa030132.66675950
14Oxidative phosphorylation_Homo sapiens_hsa001902.63571261
15RNA degradation_Homo sapiens_hsa030182.30398103
16Pyrimidine metabolism_Homo sapiens_hsa002402.21637119
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.08972769
18Parkinsons disease_Homo sapiens_hsa050122.05599787
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04593193
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98146861
21p53 signaling pathway_Homo sapiens_hsa041151.92919754
22Basal transcription factors_Homo sapiens_hsa030221.92523731
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79349847
24Sulfur metabolism_Homo sapiens_hsa009201.78403579
25mRNA surveillance pathway_Homo sapiens_hsa030151.78149937
26Propanoate metabolism_Homo sapiens_hsa006401.77461023
27Fatty acid elongation_Homo sapiens_hsa000621.61490687
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59723058
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47426566
30Herpes simplex infection_Homo sapiens_hsa051681.39872271
31Huntingtons disease_Homo sapiens_hsa050161.39533519
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35202254
33Regulation of autophagy_Homo sapiens_hsa041401.33593334
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29772513
35Purine metabolism_Homo sapiens_hsa002301.29424685
36Alzheimers disease_Homo sapiens_hsa050101.19775731
37Ribosome_Homo sapiens_hsa030101.19348591
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.18111964
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15278934
40Systemic lupus erythematosus_Homo sapiens_hsa053221.15104359
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.14851643
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13268891
43Collecting duct acid secretion_Homo sapiens_hsa049661.12195636
44Butanoate metabolism_Homo sapiens_hsa006501.08170008
45Viral carcinogenesis_Homo sapiens_hsa052031.06525000
46Selenocompound metabolism_Homo sapiens_hsa004501.05912679
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04220519
48Tryptophan metabolism_Homo sapiens_hsa003801.03606458
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03571784
50Proteasome_Homo sapiens_hsa030501.03127500
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99547652
52Epstein-Barr virus infection_Homo sapiens_hsa051690.97792565
53Measles_Homo sapiens_hsa051620.96863480
54Nitrogen metabolism_Homo sapiens_hsa009100.96536987
55Phototransduction_Homo sapiens_hsa047440.93342347
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.91889876
57Peroxisome_Homo sapiens_hsa041460.89846068
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88692102
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86463301
60Primary immunodeficiency_Homo sapiens_hsa053400.86070099
61MicroRNAs in cancer_Homo sapiens_hsa052060.85991311
62Caffeine metabolism_Homo sapiens_hsa002320.84386027
63HTLV-I infection_Homo sapiens_hsa051660.83544255
64Glutathione metabolism_Homo sapiens_hsa004800.81559063
65Antigen processing and presentation_Homo sapiens_hsa046120.74782054
66Linoleic acid metabolism_Homo sapiens_hsa005910.74731901
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.73382849
68Hematopoietic cell lineage_Homo sapiens_hsa046400.70700103
69Metabolic pathways_Homo sapiens_hsa011000.70134070
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69883670
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67948617
72Notch signaling pathway_Homo sapiens_hsa043300.67339257
73Small cell lung cancer_Homo sapiens_hsa052220.66988333
74Rheumatoid arthritis_Homo sapiens_hsa053230.66761248
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.65848217
76Ether lipid metabolism_Homo sapiens_hsa005650.64358792
77Protein export_Homo sapiens_hsa030600.63972128
78Lysine degradation_Homo sapiens_hsa003100.62297551
79Apoptosis_Homo sapiens_hsa042100.60922241
80N-Glycan biosynthesis_Homo sapiens_hsa005100.60551820
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60310080
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59517200
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59272105
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56516473
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55864729
86Hepatitis B_Homo sapiens_hsa051610.55315435
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55199465
88Pyruvate metabolism_Homo sapiens_hsa006200.53808849
89Colorectal cancer_Homo sapiens_hsa052100.53654269
90TGF-beta signaling pathway_Homo sapiens_hsa043500.52462441
91Adherens junction_Homo sapiens_hsa045200.49689711
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48898790
93Viral myocarditis_Homo sapiens_hsa054160.48059582
94Folate biosynthesis_Homo sapiens_hsa007900.47980461
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.47842552
96Prostate cancer_Homo sapiens_hsa052150.47630271
97Influenza A_Homo sapiens_hsa051640.47104833
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47011317
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46991133
100Legionellosis_Homo sapiens_hsa051340.46419242
101Chronic myeloid leukemia_Homo sapiens_hsa052200.46376011
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46116115
103Oocyte meiosis_Homo sapiens_hsa041140.45405318
104Lysosome_Homo sapiens_hsa041420.45343507
105Thyroid cancer_Homo sapiens_hsa052160.45311900
106Chemical carcinogenesis_Homo sapiens_hsa052040.44713520
107Circadian rhythm_Homo sapiens_hsa047100.44338187
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43899986
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.43185375
110Mineral absorption_Homo sapiens_hsa049780.42989751
111Vitamin digestion and absorption_Homo sapiens_hsa049770.42331403
112Basal cell carcinoma_Homo sapiens_hsa052170.40891289
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40808168
114Hippo signaling pathway_Homo sapiens_hsa043900.40472488
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40203110
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40157613
117Pathways in cancer_Homo sapiens_hsa052000.40069747
118beta-Alanine metabolism_Homo sapiens_hsa004100.39971294
119Allograft rejection_Homo sapiens_hsa053300.36802227
120Autoimmune thyroid disease_Homo sapiens_hsa053200.36756924
121Pancreatic cancer_Homo sapiens_hsa052120.36252933
122Sphingolipid metabolism_Homo sapiens_hsa006000.35900645
123Leishmaniasis_Homo sapiens_hsa051400.35617755
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.35573076
125Type I diabetes mellitus_Homo sapiens_hsa049400.34815136
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34353338
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.34263558
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33763807
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33263878
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32205738
131Vitamin B6 metabolism_Homo sapiens_hsa007500.32112479
132FoxO signaling pathway_Homo sapiens_hsa040680.31730802
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30690085
134Acute myeloid leukemia_Homo sapiens_hsa052210.30607951
135Alcoholism_Homo sapiens_hsa050340.30072955
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.29528768
137Fatty acid degradation_Homo sapiens_hsa000710.29220137
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28981209
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.27990298
140Asthma_Homo sapiens_hsa053100.27812851
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27564304
142Steroid biosynthesis_Homo sapiens_hsa001000.27535619
143Arachidonic acid metabolism_Homo sapiens_hsa005900.27303111
144TNF signaling pathway_Homo sapiens_hsa046680.27122831
145Dorso-ventral axis formation_Homo sapiens_hsa043200.26242074
146Wnt signaling pathway_Homo sapiens_hsa043100.25632710
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25136187
148Pentose phosphate pathway_Homo sapiens_hsa000300.24506659
149Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24342774
150Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23236497

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »