HUS1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptonemal complex assembly (GO:0007130)9.13016092
2DNA methylation involved in gamete generation (GO:0043046)8.60927895
3synaptonemal complex organization (GO:0070193)8.39779396
4male meiosis (GO:0007140)7.23440210
5negative regulation of inclusion body assembly (GO:0090084)7.13807565
6chromosome organization involved in meiosis (GO:0070192)6.57466327
7meiotic nuclear division (GO:0007126)6.53697085
8tolerance induction (GO:0002507)6.06664777
9histone H3-K36 demethylation (GO:0070544)5.83179558
10male meiosis I (GO:0007141)5.71168444
11regulation of meiosis I (GO:0060631)5.58303559
12receptor recycling (GO:0001881)5.31650812
13positive regulation of T cell cytokine production (GO:0002726)5.30322220
14DNA replication checkpoint (GO:0000076)5.30142220
15meiotic chromosome segregation (GO:0045132)5.25896438
16maturation of SSU-rRNA (GO:0030490)5.09027511
17protein refolding (GO:0042026)5.03152123
18meiosis I (GO:0007127)4.85871613
19meiotic cell cycle process (GO:1903046)4.79309158
20protein K6-linked ubiquitination (GO:0085020)4.71680882
21DNA alkylation (GO:0006305)4.52937044
22DNA methylation (GO:0006306)4.52937044
23reciprocal DNA recombination (GO:0035825)4.48434618
24reciprocal meiotic recombination (GO:0007131)4.48434618
25cell wall macromolecule catabolic process (GO:0016998)4.33263482
26embryonic body morphogenesis (GO:0010172)4.31587914
27oocyte maturation (GO:0001556)4.29698351
28oogenesis (GO:0048477)4.27468714
29histone H3-K9 demethylation (GO:0033169)4.21490363
30ribosomal large subunit biogenesis (GO:0042273)4.16674648
31sister chromatid cohesion (GO:0007062)4.13933890
32resolution of meiotic recombination intermediates (GO:0000712)4.10722062
33proteasome assembly (GO:0043248)4.01515315
34cornea development in camera-type eye (GO:0061303)3.97435882
35synapsis (GO:0007129)3.96983632
36DNA methylation or demethylation (GO:0044728)3.94952082
37regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.83066757
38regulation of NFAT protein import into nucleus (GO:0051532)3.82284894
39ribosome assembly (GO:0042255)3.80877849
40DNA replication-dependent nucleosome organization (GO:0034723)3.78958373
41DNA replication-dependent nucleosome assembly (GO:0006335)3.78958373
42blastocyst development (GO:0001824)3.78499184
43DNA synthesis involved in DNA repair (GO:0000731)3.76721597
44positive regulation of translational initiation (GO:0045948)3.74653671
45endoderm formation (GO:0001706)3.74377564
46gene silencing by RNA (GO:0031047)3.73321678
47purine nucleobase biosynthetic process (GO:0009113)3.71395247
48regulation of T cell cytokine production (GO:0002724)3.70864106
49ribosomal small subunit biogenesis (GO:0042274)3.69113443
50regulation of inclusion body assembly (GO:0090083)3.68755553
51kinetochore organization (GO:0051383)3.67622504
52negative regulation of meiosis (GO:0045835)3.66952584
53cellular response to prostaglandin stimulus (GO:0071379)3.65764274
54sleep (GO:0030431)3.64143326
55mating behavior (GO:0007617)3.64106628
56ribonucleoprotein complex biogenesis (GO:0022613)3.60982056
57establishment of integrated proviral latency (GO:0075713)3.59863053
58pseudouridine synthesis (GO:0001522)3.56895372
59somatic hypermutation of immunoglobulin genes (GO:0016446)3.56361261
60somatic diversification of immune receptors via somatic mutation (GO:0002566)3.56361261
61metallo-sulfur cluster assembly (GO:0031163)3.56089922
62iron-sulfur cluster assembly (GO:0016226)3.56089922
63establishment of protein localization to mitochondrial membrane (GO:0090151)3.55621715
64DNA modification (GO:0006304)3.54561552
65positive regulation of receptor biosynthetic process (GO:0010870)3.50889138
66regulation of transcription from RNA polymerase I promoter (GO:0006356)3.50651627
67cell wall macromolecule metabolic process (GO:0044036)3.49359159
68kinetochore assembly (GO:0051382)3.47927549
69nucleobase biosynthetic process (GO:0046112)3.47793646
70ribosome biogenesis (GO:0042254)3.45977554
71ribosomal small subunit assembly (GO:0000028)3.40112552
72negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.39536097
73negative regulation of cell killing (GO:0031342)3.39536097
74ovulation cycle (GO:0042698)3.39053464
75establishment of viral latency (GO:0019043)3.36859480
76positive regulation of cellular response to oxidative stress (GO:1900409)3.31207413
77positive regulation of response to oxidative stress (GO:1902884)3.31207413
78nuclear pore complex assembly (GO:0051292)3.30535593
79nuclear pore organization (GO:0006999)3.27915306
807-methylguanosine mRNA capping (GO:0006370)3.25777130
81lymphoid progenitor cell differentiation (GO:0002320)3.25702019
82attachment of spindle microtubules to kinetochore (GO:0008608)3.25347523
83spliceosomal tri-snRNP complex assembly (GO:0000244)3.24528293
84DNA replication initiation (GO:0006270)3.24474257
85body morphogenesis (GO:0010171)3.22690742
86DNA ligation (GO:0006266)3.22492383
87positive regulation of odontogenesis (GO:0042482)3.21069786
88translational termination (GO:0006415)3.20580374
89viral transcription (GO:0019083)3.17727623
90protein destabilization (GO:0031648)3.16971581
91histone H4-K12 acetylation (GO:0043983)3.16825983
92protein localization to chromosome (GO:0034502)3.16293471
937-methylguanosine RNA capping (GO:0009452)3.16120414
94RNA capping (GO:0036260)3.16120414
95formation of translation preinitiation complex (GO:0001731)3.15724685
96male sex determination (GO:0030238)3.11287040
97L-fucose catabolic process (GO:0042355)3.09776315
98fucose catabolic process (GO:0019317)3.09776315
99L-fucose metabolic process (GO:0042354)3.09776315
100DNA strand elongation involved in DNA replication (GO:0006271)3.09566843
101positive regulation of meiosis (GO:0045836)3.09153234
102sperm-egg recognition (GO:0035036)3.08706641
103histone exchange (GO:0043486)3.07058918
104histone H3-K9 methylation (GO:0051567)3.05643705
105histone H2A acetylation (GO:0043968)3.02243429
106regulation of histone H3-K9 methylation (GO:0051570)3.01475826
107regulation of double-strand break repair via homologous recombination (GO:0010569)3.00884996
108rRNA processing (GO:0006364)2.98444255
109regulation of posttranscriptional gene silencing (GO:0060147)2.96916035
110regulation of gene silencing by miRNA (GO:0060964)2.96916035
111regulation of gene silencing by RNA (GO:0060966)2.96916035
112protein-cofactor linkage (GO:0018065)2.96512773
113positive regulation by host of viral transcription (GO:0043923)2.95356180
114heterochromatin organization (GO:0070828)2.94720974
115positive regulation of prostaglandin secretion (GO:0032308)2.93546169
116cell-cell recognition (GO:0009988)2.93225472
117transcription elongation from RNA polymerase I promoter (GO:0006362)2.92586744
118transcription from RNA polymerase I promoter (GO:0006360)2.92013799
119mRNA transcription from RNA polymerase II promoter (GO:0042789)2.91847937
120chromatin remodeling at centromere (GO:0031055)2.91415560
121DNA strand elongation (GO:0022616)2.90296391
122negative regulation of erythrocyte differentiation (GO:0045647)2.90289994
123termination of RNA polymerase I transcription (GO:0006363)2.90104413
124DNA deamination (GO:0045006)2.89865124
125translational initiation (GO:0006413)2.89667507
126acrosome assembly (GO:0001675)2.89575259
127rRNA metabolic process (GO:0016072)2.89172545
128cullin deneddylation (GO:0010388)2.87987939
129protein neddylation (GO:0045116)2.85531054
130positive regulation of meiotic cell cycle (GO:0051446)2.85472309
131RNA localization (GO:0006403)2.84779116
132positive regulation of bone resorption (GO:0045780)2.84714316
133positive regulation of bone remodeling (GO:0046852)2.84714316
134metaphase plate congression (GO:0051310)2.84297766
135regulation of telomere maintenance via telomerase (GO:0032210)2.83522362
136female gamete generation (GO:0007292)2.83326792
137binding of sperm to zona pellucida (GO:0007339)2.82945666
138mitotic spindle checkpoint (GO:0071174)2.82896644
139mitotic metaphase plate congression (GO:0007080)2.82386321
140histone H4-K8 acetylation (GO:0043982)2.82091691
141histone H4-K5 acetylation (GO:0043981)2.82091691
142neural tube formation (GO:0001841)2.81860917
143negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.81632052
144telomere maintenance via semi-conservative replication (GO:0032201)2.80305603
145spindle checkpoint (GO:0031577)2.79792379
146negative regulation of mitotic sister chromatid separation (GO:2000816)2.79758873
147negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79758873
148negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79758873
149negative regulation of sister chromatid segregation (GO:0033046)2.79758873
150negative regulation of DNA recombination (GO:0045910)2.79309994
151positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.78578389
152negative regulation of chromosome segregation (GO:0051985)2.78572019
153negative regulation of DNA-dependent DNA replication (GO:2000104)2.78338677
154transcription-coupled nucleotide-excision repair (GO:0006283)2.77687993
155signal transduction involved in DNA integrity checkpoint (GO:0072401)2.77089436
156negative regulation of gene silencing (GO:0060969)2.73926608
157signal complex assembly (GO:0007172)2.71681250
158mitotic sister chromatid cohesion (GO:0007064)2.70459242
159V(D)J recombination (GO:0033151)2.69326747
160embryonic heart tube development (GO:0035050)2.65728666
161intraciliary transport (GO:0042073)2.61692552
162histone H4-K16 acetylation (GO:0043984)2.60568820
163positive regulation of skeletal muscle tissue development (GO:0048643)2.59572045
164ubiquinone biosynthetic process (GO:0006744)2.57257879
165regulation of immunoglobulin secretion (GO:0051023)2.56811553
166histone H3-K9 modification (GO:0061647)2.56714609
167ubiquinone metabolic process (GO:0006743)2.56377543
168macroautophagy (GO:0016236)2.55823032
169negative regulation of NF-kappaB import into nucleus (GO:0042347)2.55149769
170positive regulation of heat generation (GO:0031652)2.49536852
171regulation of meiotic cell cycle (GO:0051445)2.49522534
172regulation of transcription involved in cell fate commitment (GO:0060850)2.48372055
173regulation of microtubule-based movement (GO:0060632)2.48021068
174histone lysine demethylation (GO:0070076)2.47608666
175positive regulation of osteoclast differentiation (GO:0045672)2.46865446
176piRNA metabolic process (GO:0034587)10.6156844

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.12270825
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.75518041
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.19320223
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.77292694
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.52148674
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.46536619
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.33377236
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20328173
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.11529946
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.03383670
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87903439
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.82664580
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82289686
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.77631017
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.66768006
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63420566
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59639536
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.55962859
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50037007
20VDR_23849224_ChIP-Seq_CD4+_Human2.43902853
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43071415
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.37445303
23RUNX1_17652178_ChIP-ChIP_JURKAT_Human2.20899900
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.20651737
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18934770
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18307163
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.16617469
28EZH2_22144423_ChIP-Seq_EOC_Human2.14606340
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13316786
30RUNX_20019798_ChIP-Seq_JUKART_Human2.12484454
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.10123088
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09199810
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05972118
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05658919
35HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse2.03424880
36XRN2_22483619_ChIP-Seq_HELA_Human2.00710401
37ELK1_19687146_ChIP-ChIP_HELA_Human1.97943190
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97117322
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93489986
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91979129
41AR_21909140_ChIP-Seq_LNCAP_Human1.91521612
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90475606
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89388217
44DCP1A_22483619_ChIP-Seq_HELA_Human1.88538470
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.87687999
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.85015688
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.84621900
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.84621900
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.84621900
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84058776
51* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82391699
52PKCTHETA_26484144_Chip-Seq_BREAST_Human1.81863959
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80352272
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.73230975
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67349946
56FOXP3_21729870_ChIP-Seq_TREG_Human1.63750363
57TTF2_22483619_ChIP-Seq_HELA_Human1.62914045
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56937603
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54907514
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.53550785
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53480143
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.51615519
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51177651
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51157359
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50951180
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49540648
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.48457579
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43665183
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38964477
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38548679
71UTX_26944678_Chip-Seq_JUKART_Human1.36139031
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33546957
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33315226
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.32315948
75MYC_18940864_ChIP-ChIP_HL60_Human1.31407917
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29077975
77CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27291708
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25507864
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25017002
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23444667
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21695832
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20287631
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19828952
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18946703
85WT1_19549856_ChIP-ChIP_CCG9911_Human1.18944347
86GABP_19822575_ChIP-Seq_HepG2_Human1.18835543
87ERA_21632823_ChIP-Seq_H3396_Human1.17679780
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17099389
89RNF2_27304074_Chip-Seq_NSC_Mouse1.16434098
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15825103
91PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15409154
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13864366
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.12500121
94MYB_26560356_Chip-Seq_TH2_Human1.11992484
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11949988
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11578492
97SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.10653831
98FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09779109
99* BCOR_27268052_Chip-Seq_Bcells_Human1.09125245
100SALL1_21062744_ChIP-ChIP_HESCs_Human1.08466455
101CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07782162
102MYB_26560356_Chip-Seq_TH1_Human1.06907551
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06889553
104FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06837561
105EGR1_19032775_ChIP-ChIP_M12_Human1.06577168
106TP53_22573176_ChIP-Seq_HFKS_Human1.01965090
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01928933
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01852538
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99450141
110KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98100542
111FUS_26573619_Chip-Seq_HEK293_Human0.96363287
112P68_20966046_ChIP-Seq_HELA_Human0.96141477
113P300_27268052_Chip-Seq_Bcells_Human0.95215089
114MAF_26560356_Chip-Seq_TH2_Human0.95084381
115NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94189335
116PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93881521
117VDR_21846776_ChIP-Seq_THP-1_Human0.93031034
118KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92888019
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92728898
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92427000
121* GATA3_21867929_ChIP-Seq_TH1_Mouse0.92400328
122HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92092621
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91459178
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91016146
125SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88508196
126NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86881026
127RUNX1_26923725_Chip-Seq_HPCs_Mouse0.86807787
128CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.86040824
129NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85817827
130SRF_21415370_ChIP-Seq_HL-1_Mouse0.85586261
131ELK1_22589737_ChIP-Seq_MCF10A_Human0.84754762
132CIITA_25753668_ChIP-Seq_RAJI_Human0.84492287
133EWS_26573619_Chip-Seq_HEK293_Human0.84018622
134GATA1_26923725_Chip-Seq_HPCs_Mouse0.83330214
135KDM5A_27292631_Chip-Seq_BREAST_Human0.83179810
136KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81734055
137NFE2_27457419_Chip-Seq_LIVER_Mouse0.81501430
138HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77449987
139BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77037621
140TFEB_21752829_ChIP-Seq_HELA_Human0.74176108
141CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.72971988
142RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.69680183
143E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.68468947
144SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.66992939
145SUZ12_27294783_Chip-Seq_NPCs_Mouse0.66188331
146TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.66110650
147SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.62363326

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation8.35683620
2MP0003693_abnormal_embryo_hatching4.84702455
3MP0008995_early_reproductive_senescence4.68138308
4MP0004233_abnormal_muscle_weight4.27444602
5MP0008058_abnormal_DNA_repair4.19993025
6MP0003123_paternal_imprinting4.04138725
7MP0003786_premature_aging3.86760621
8MP0010094_abnormal_chromosome_stability3.72404168
9MP0002210_abnormal_sex_determination3.64203425
10MP0003111_abnormal_nucleus_morphology3.38024802
11MP0000465_gastrointestinal_hemorrhage3.22435534
12MP0001929_abnormal_gametogenesis3.04815319
13MP0001145_abnormal_male_reproductive2.94445441
14MP0009697_abnormal_copulation2.78028318
15MP0004957_abnormal_blastocyst_morpholog2.72999232
16MP0003698_abnormal_male_reproductive2.55312389
17MP0005410_abnormal_fertilization2.54684776
18MP0000653_abnormal_sex_gland2.53932399
19MP0003718_maternal_effect2.41948432
20MP0003077_abnormal_cell_cycle2.41705607
21MP0002254_reproductive_system_inflammat2.29798930
22MP0003763_abnormal_thymus_physiology2.23539592
23MP0008057_abnormal_DNA_replication2.03619119
24MP0005310_abnormal_salivary_gland2.03430219
25MP0002277_abnormal_respiratory_mucosa1.91674025
26MP0008932_abnormal_embryonic_tissue1.87816510
27MP0000685_abnormal_immune_system1.82929381
28MP0001730_embryonic_growth_arrest1.81260280
29MP0001188_hyperpigmentation1.68134134
30MP0004084_abnormal_cardiac_muscle1.66250814
31MP0004808_abnormal_hematopoietic_stem1.64328904
32MP0002928_abnormal_bile_duct1.63826566
33MP0010352_gastrointestinal_tract_polyps1.61536142
34MP0005623_abnormal_meninges_morphology1.56351043
35MP0003724_increased_susceptibility_to1.53706205
36MP0005671_abnormal_response_to1.51946087
37MP0002405_respiratory_system_inflammati1.51227398
38MP0009379_abnormal_foot_pigmentation1.43276660
39MP0005167_abnormal_blood-brain_barrier1.43112721
40MP0001348_abnormal_lacrimal_gland1.40628209
41MP0002161_abnormal_fertility/fecundity1.40049657
42MP0008961_abnormal_basal_metabolism1.37994884
43MP0005389_reproductive_system_phenotype1.35742231
44MP0001873_stomach_inflammation1.35463629
45MP0001727_abnormal_embryo_implantation1.35005441
46MP0003950_abnormal_plasma_membrane1.30729472
47MP0008007_abnormal_cellular_replicative1.30641724
48MP0001485_abnormal_pinna_reflex1.29722800
49MP0003941_abnormal_skin_development1.28931502
50MP0002332_abnormal_exercise_endurance1.27853972
51MP0001346_abnormal_lacrimal_gland1.25683061
52MP0008260_abnormal_autophagy1.25052681
53MP0002163_abnormal_gland_morphology1.22792760
54MP0000350_abnormal_cell_proliferation1.22780959
55MP0003136_yellow_coat_color1.21767561
56MP0005084_abnormal_gallbladder_morpholo1.21272165
57MP0005187_abnormal_penis_morphology1.17161396
58MP0001502_abnormal_circadian_rhythm1.15884989
59MP0001986_abnormal_taste_sensitivity1.15867624
60MP0003303_peritoneal_inflammation1.14885308
61MP0010307_abnormal_tumor_latency1.14672945
62MP0001919_abnormal_reproductive_system1.14162305
63MP0002138_abnormal_hepatobiliary_system1.13340886
64MP0001800_abnormal_humoral_immune1.10893575
65MP0006276_abnormal_autonomic_nervous1.09791897
66MP0001529_abnormal_vocalization1.09644812
67MP0000647_abnormal_sebaceous_gland1.09343900
68MP0004272_abnormal_basement_membrane1.08486005
69MP0003172_abnormal_lysosome_physiology1.07919216
70MP0003436_decreased_susceptibility_to1.07210920
71MP0002722_abnormal_immune_system1.06723303
72MP0000383_abnormal_hair_follicle0.99680757
73MP0005423_abnormal_somatic_nervous0.99672110
74MP0002160_abnormal_reproductive_system0.97968550
75MP0000427_abnormal_hair_cycle0.97245380
76MP0003943_abnormal_hepatobiliary_system0.97197243
77MP0000313_abnormal_cell_death0.97079879
78MP0002398_abnormal_bone_marrow0.96809978
79MP0004197_abnormal_fetal_growth/weight/0.95910144
80MP0001851_eye_inflammation0.95767665
81MP0005000_abnormal_immune_tolerance0.94704849
82MP0006035_abnormal_mitochondrial_morpho0.94261873
83MP0003121_genomic_imprinting0.93528554
84MP0002876_abnormal_thyroid_physiology0.93333423
85MP0001119_abnormal_female_reproductive0.92471159
86MP0001672_abnormal_embryogenesis/_devel0.90687374
87MP0005380_embryogenesis_phenotype0.90687374
88MP0006072_abnormal_retinal_apoptosis0.90058337
89MP0005647_abnormal_sex_gland0.88983228
90MP0002282_abnormal_trachea_morphology0.88974501
91MP0001790_abnormal_immune_system0.88860637
92MP0005387_immune_system_phenotype0.88860637
93MP0003806_abnormal_nucleotide_metabolis0.88614695
94MP0004133_heterotaxia0.85481717
95MP0004134_abnormal_chest_morphology0.85350476
96MP0000689_abnormal_spleen_morphology0.84976579
97MP0009672_abnormal_birth_weight0.84166558
98MP0002723_abnormal_immune_serum0.83998901
99MP0002019_abnormal_tumor_incidence0.83504591
100MP0001697_abnormal_embryo_size0.83351430
101MP0005409_darkened_coat_color0.79854981
102MP0005395_other_phenotype0.79809350
103MP0002080_prenatal_lethality0.78935187
104MP0001819_abnormal_immune_cell0.78620718
105MP0000716_abnormal_immune_system0.77724217
106MP0002420_abnormal_adaptive_immunity0.77284081
107MP0002653_abnormal_ependyma_morphology0.77041759
108MP0003984_embryonic_growth_retardation0.76679292
109MP0003828_pulmonary_edema0.76668378
110MP0000762_abnormal_tongue_morphology0.75918692
111MP0002085_abnormal_embryonic_tissue0.74928554
112MP0004036_abnormal_muscle_relaxation0.74888410
113MP0002396_abnormal_hematopoietic_system0.74859921
114MP0001293_anophthalmia0.74412104
115MP0004484_altered_response_of0.73810692
116MP0003646_muscle_fatigue0.73381763
117MP0009115_abnormal_fat_cell0.73208210
118MP0002086_abnormal_extraembryonic_tissu0.72476853
119MP0009250_abnormal_appendicular_skeleto0.72243947
120MP0004510_myositis0.72229979
121MP0009278_abnormal_bone_marrow0.72064785
122MP0005171_absent_coat_pigmentation0.71926146
123MP0002933_joint_inflammation0.71347077
124MP0004947_skin_inflammation0.70219464
125MP0003699_abnormal_female_reproductive0.69570973
126MP0002088_abnormal_embryonic_growth/wei0.68699776
127MP0003755_abnormal_palate_morphology0.67950546
128MP0005670_abnormal_white_adipose0.65666884
129MP0003959_abnormal_lean_body0.64996369
130MP0000778_abnormal_nervous_system0.64430427
131MP0004043_abnormal_pH_regulation0.63702607
132MP0001661_extended_life_span0.63418125
133MP0002970_abnormal_white_adipose0.63075241
134MP0009703_decreased_birth_body0.62294764
135MP0001324_abnormal_eye_pigmentation0.61592997
136MP0002084_abnormal_developmental_patter0.60859668
137MP0002127_abnormal_cardiovascular_syste0.60267357
138MP0001944_abnormal_pancreas_morphology0.60025890
139MP0005646_abnormal_pituitary_gland0.60019511
140MP0003186_abnormal_redox_activity0.59266480
141MP0002693_abnormal_pancreas_physiology0.58736953
142MP0000516_abnormal_urinary_system0.58564377
143MP0005367_renal/urinary_system_phenotyp0.58564377
144MP0003119_abnormal_digestive_system0.58494690
145MP0004142_abnormal_muscle_tone0.58461146
146MP0000470_abnormal_stomach_morphology0.57852606
147MP0002452_abnormal_antigen_presenting0.57714051
148MP0005266_abnormal_metabolism0.57144916
149MP0002095_abnormal_skin_pigmentation0.56582330
150MP0003890_abnormal_embryonic-extraembry0.55595862
151MP0003937_abnormal_limbs/digits/tail_de0.55040784
152MP0001545_abnormal_hematopoietic_system0.52612022
153MP0005397_hematopoietic_system_phenotyp0.52612022
154MP0003566_abnormal_cell_adhesion0.52571643
155MP0000703_abnormal_thymus_morphology0.49175173
156MP0004381_abnormal_hair_follicle0.47988244
157MP0000432_abnormal_head_morphology0.47791581
158MP0003936_abnormal_reproductive_system0.47557467
159MP0001542_abnormal_bone_strength0.46618775
160MP0002909_abnormal_adrenal_gland0.46374166
161MP0001915_intracranial_hemorrhage0.45144443
162MP0003315_abnormal_perineum_morphology0.44553128
163MP0005253_abnormal_eye_physiology0.44439887
164MP0005408_hypopigmentation0.43838153
165MP0001853_heart_inflammation0.42202185
166MP0000015_abnormal_ear_pigmentation0.41173816
167MP0006138_congestive_heart_failure0.40204191

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)6.78859249
2Azoospermia (HP:0000027)6.58377788
3Abnormal spermatogenesis (HP:0008669)6.07243113
4Epiphyseal dysplasia (HP:0002656)5.69237757
5Carpal bone hypoplasia (HP:0001498)5.62062163
6Type 2 muscle fiber atrophy (HP:0003554)5.40112287
7Muscle fiber atrophy (HP:0100295)5.27344230
8Vitreoretinal degeneration (HP:0000655)4.97165110
9Small epiphyses (HP:0010585)4.84654776
10Shoulder girdle muscle weakness (HP:0003547)4.72217791
11Birth length less than 3rd percentile (HP:0003561)4.39342592
12Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.20367293
13Weak cry (HP:0001612)4.19550875
1411 pairs of ribs (HP:0000878)3.69344904
15Increased density of long bones (HP:0006392)3.63179091
16B lymphocytopenia (HP:0010976)3.59407256
17Hypoplastic ischia (HP:0003175)3.53290095
18Fibular hypoplasia (HP:0003038)3.50939667
19Genu varum (HP:0002970)3.38761992
20Severe combined immunodeficiency (HP:0004430)3.38032314
21Gonadotropin excess (HP:0000837)3.33507334
22Volvulus (HP:0002580)3.31733776
23Breast hypoplasia (HP:0003187)3.30179110
24Stenosis of the external auditory canal (HP:0000402)3.28098516
25Poor suck (HP:0002033)3.26246613
26Tubulointerstitial nephritis (HP:0001970)3.20650356
27Amyotrophic lateral sclerosis (HP:0007354)3.19052569
28High anterior hairline (HP:0009890)3.18774011
29Broad distal phalanx of finger (HP:0009836)3.18174136
30Oligodactyly (hands) (HP:0001180)3.17244274
31Aplasia/Hypoplasia of the fibula (HP:0006492)3.15134204
32Mild short stature (HP:0003502)3.14121253
33Reticulocytopenia (HP:0001896)3.09761667
34Absent radius (HP:0003974)3.08892377
35Combined immunodeficiency (HP:0005387)3.06479972
36Abnormality of the ischium (HP:0003174)3.00751184
37Homocystinuria (HP:0002156)2.99988921
38Abnormality of homocysteine metabolism (HP:0010919)2.99988921
39Abnormality of the columella (HP:0009929)2.98048426
40Absent forearm bone (HP:0003953)2.96514157
41Aplasia involving forearm bones (HP:0009822)2.96514157
42Abnormality of the labia minora (HP:0012880)2.95577212
43Delayed epiphyseal ossification (HP:0002663)2.95075470
44IgG deficiency (HP:0004315)2.87529670
45Bulbar palsy (HP:0001283)2.85318989
46Rimmed vacuoles (HP:0003805)2.82230930
47Absent epiphyses (HP:0010577)2.79546231
48Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.79546231
49Abnormality of B cell number (HP:0010975)2.79304982
50Flat capital femoral epiphysis (HP:0003370)2.78325474
51Degeneration of the lateral corticospinal tracts (HP:0002314)2.76532070
52Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.76532070
53Hydroureter (HP:0000072)2.73797748
54Colon cancer (HP:0003003)2.71707466
55Horizontal nystagmus (HP:0000666)2.69354777
56Hypoplasia of the thymus (HP:0000778)2.68232798
57Absent thumb (HP:0009777)2.67286291
58Conjunctival telangiectasia (HP:0000524)2.65308732
59Abnormality of the lower motor neuron (HP:0002366)2.64965974
60Rough bone trabeculation (HP:0100670)2.63172185
61Easy fatigability (HP:0003388)2.54408274
62Agnosia (HP:0010524)2.54169203
63Spontaneous abortion (HP:0005268)2.54090608
64Decreased muscle mass (HP:0003199)2.53523487
65Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.50917081
66Abnormality of the vasculature of the conjunctiva (HP:0008054)2.50342450
67Abnormality of the neuromuscular junction (HP:0003398)2.49862932
68Fatigable weakness (HP:0003473)2.49862932
69Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.49116582
70Abnormality of femoral epiphyses (HP:0006499)2.49116582
71Long foot (HP:0001833)2.47052722
72Nonprogressive disorder (HP:0003680)2.45052494
73IgM deficiency (HP:0002850)2.44286766
74Abnormality of DNA repair (HP:0003254)2.43790016
75Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.42504437
76Duplicated collecting system (HP:0000081)2.41305978
77Missing ribs (HP:0000921)2.40825272
78Abnormality of the proximal phalanges of the hand (HP:0009834)2.39251692
79Capillary hemangiomas (HP:0005306)2.37350804
80Recurrent bronchitis (HP:0002837)2.35379460
81Glossoptosis (HP:0000162)2.33928233
82Impulsivity (HP:0100710)2.33849073
83Medulloblastoma (HP:0002885)2.32417553
84Abnormality of the hip-girdle musculature (HP:0001445)2.32313380
85Abnormality of the musculature of the pelvis (HP:0001469)2.32313380
86Rhabdomyosarcoma (HP:0002859)2.31655177
87Abnormality of the phalanges of the 2nd finger (HP:0009541)2.29717793
88Horseshoe kidney (HP:0000085)2.28369964
89Cerebral hypomyelination (HP:0006808)2.26134131
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.25909294
91Metaphyseal cupping (HP:0003021)2.21541803
92Abnormality of cells of the erythroid lineage (HP:0012130)2.21348707
93Menstrual irregularities (HP:0000858)2.21266695
94Tetraparesis (HP:0002273)2.20338379
95Gastrointestinal infarctions (HP:0005244)2.19585807
96Mesomelia (HP:0003027)2.19119883
97Thin ribs (HP:0000883)2.18007849
98Abnormality of the epiphysis of the femoral head (HP:0010574)2.17551417
99Basal cell carcinoma (HP:0002671)2.17158537
100Hypoplastic iliac wings (HP:0002866)2.17023428
101Upper motor neuron abnormality (HP:0002127)2.15866249
102Chromsome breakage (HP:0040012)2.14701830
103Rectal fistula (HP:0100590)2.14184335
104Rectovaginal fistula (HP:0000143)2.14184335
105Ependymoma (HP:0002888)2.14093061
106Aplasia/Hypoplasia of the ulna (HP:0006495)2.12185897
107Short tibia (HP:0005736)2.11731934
108Atrophy/Degeneration involving motor neurons (HP:0007373)2.11157167
109Alveolar cell carcinoma (HP:0006519)2.10378308
110Neoplasm of the tracheobronchial system (HP:0100552)2.10275289
111Gait imbalance (HP:0002141)2.09811005
112Optic nerve coloboma (HP:0000588)2.09561535
113Facial cleft (HP:0002006)2.09125069
114Upper limb muscle weakness (HP:0003484)2.09080256
115Fibular aplasia (HP:0002990)2.07876171
116Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.07857918
117Nephrogenic diabetes insipidus (HP:0009806)2.07317470
118Synostosis of carpal bones (HP:0005048)2.06915636
119Slow-growing hair (HP:0002217)2.06856277
120Abnormality of hair growth rate (HP:0011363)2.06856277
121Poor eye contact (HP:0000817)2.06310468
122Patellar aplasia (HP:0006443)2.05984577
123Lissencephaly (HP:0001339)2.04047985
124Pelvic girdle muscle weakness (HP:0003749)2.03995602
125Stillbirth (HP:0003826)2.03809643
126Bicuspid aortic valve (HP:0001647)2.03386529
127Aplasia/Hypoplasia of the patella (HP:0006498)2.03363662
128Widely spaced teeth (HP:0000687)2.01739171
129Flattened epiphyses (HP:0003071)2.00973008
130Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00507558
131Neoplasm of striated muscle (HP:0009728)2.00208363
132Limb-girdle muscle weakness (HP:0003325)2.00161482
133Proximal placement of thumb (HP:0009623)2.00087866
134Ureteral duplication (HP:0000073)1.99733844
135Short ribs (HP:0000773)1.99413333
136Congenital primary aphakia (HP:0007707)1.99260483
137Abnormality of the femoral head (HP:0003368)1.99137551
138Premature graying of hair (HP:0002216)1.99016502
139Peripheral hypomyelination (HP:0007182)1.99007343
140Progressive external ophthalmoplegia (HP:0000590)1.98751469
141Ureteral stenosis (HP:0000071)1.98476477
142Increased IgM level (HP:0003496)1.97617514
143Poor coordination (HP:0002370)1.97057554
144Intestinal fistula (HP:0100819)1.95537654
145Abnormality of incisor morphology (HP:0011063)1.94648565
146Clumsiness (HP:0002312)1.94463682
147Decreased subcutaneous fat (HP:0001002)1.93388873
148Medial flaring of the eyebrow (HP:0010747)1.92432776
149Macrocytic anemia (HP:0001972)1.90387509
150Absent frontal sinuses (HP:0002688)1.89841720
151Abnormal number of erythroid precursors (HP:0012131)1.89810607
152Abnormality of the frontal sinuses (HP:0002687)1.88488008
153Persistence of primary teeth (HP:0006335)1.88361977
154Neoplasm of the oral cavity (HP:0100649)1.88031605
155Abnormal protein glycosylation (HP:0012346)1.87294412
156Abnormal glycosylation (HP:0012345)1.87294412
157Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87294412
158Abnormal protein N-linked glycosylation (HP:0012347)1.87294412
159Abnormality of the aortic arch (HP:0012303)1.86820264
160Aplasia/Hypoplasia of the tibia (HP:0005772)1.86690956
161Carpal synostosis (HP:0009702)1.86628584
162Abnormality of the renal collecting system (HP:0004742)1.86584808
163Relative macrocephaly (HP:0004482)1.85804382
164Urethral obstruction (HP:0000796)1.85554051
165Nephronophthisis (HP:0000090)1.83137972
166Oligodactyly (HP:0012165)1.82624953
167Abnormality of T cell number (HP:0011839)1.80862106
168Premature ovarian failure (HP:0008209)1.79451628
169Hyperventilation (HP:0002883)1.79240688
170Supernumerary bones of the axial skeleton (HP:0009144)1.78899715
171Large hands (HP:0001176)1.78561006
172Supernumerary ribs (HP:0005815)1.76880341
173Abnormality of T cells (HP:0002843)1.76745625
174Hypoplasia of the radius (HP:0002984)1.75985651
175Arthropathy (HP:0003040)1.75937399
176Truncal obesity (HP:0001956)1.75532194
177Absent speech (HP:0001344)1.75211155
178Abnormality of the corticospinal tract (HP:0002492)1.75077622
179Short thumb (HP:0009778)1.74081781
180Spinal muscular atrophy (HP:0007269)1.73771347
181Ulnar claw (HP:0001178)1.73759850
182Long clavicles (HP:0000890)1.73612345
183Aplasia/Hypoplasia involving the musculature (HP:0001460)1.73112127
184Squamous cell carcinoma (HP:0002860)1.72775877
185Median cleft lip (HP:0000161)1.72314233
186Supernumerary spleens (HP:0009799)1.71184487
187Tubulointerstitial abnormality (HP:0001969)1.70984305
188Ureteral obstruction (HP:0006000)1.69612572
189Cutis marmorata (HP:0000965)1.69460516
190Hypoplasia of the ulna (HP:0003022)1.67842779
191Facial hemangioma (HP:0000329)1.67659209
192Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.67416918
193Aplasia/hypoplasia of the humerus (HP:0006507)1.67359657

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.40628022
2CDC74.06533676
3MAP4K23.98507826
4WEE13.90229317
5CDK193.67602314
6TAOK33.47349561
7PNCK3.10563556
8STK163.03628446
9BUB13.00791710
10IRAK32.62046615
11SIK22.57617552
12PRKD32.51390185
13BRSK22.41792219
14FES2.16471127
15MAPK152.06856762
16EIF2AK31.99002104
17MAP3K101.97937785
18CDK121.96902710
19PBK1.88020785
20ZAK1.87129757
21PLK41.84817367
22TTK1.82852210
23CAMK1G1.79847635
24SIK31.79738458
25NME11.72532504
26MAP3K31.69453327
27PLK11.67130323
28MST41.66208121
29NLK1.62240584
30BMX1.60708220
31SRPK11.60275048
32PLK31.51433262
33VRK11.44546815
34BRSK11.44040219
35TSSK61.40210867
36TLK11.39054764
37EPHA21.38868279
38PRKG21.36269374
39CHEK21.36039068
40TIE11.35713276
41CHEK11.34086188
42MAP2K21.33633833
43STK241.29774392
44PDK21.29219026
45BCR1.26972629
46TYRO31.26257867
47KDR1.26093110
48EIF2AK11.25201059
49MAP3K41.24824814
50CSF1R1.24226607
51AKT31.21872602
52OXSR11.19062771
53ICK1.18425244
54BRD41.18158762
55MARK11.18029881
56CASK1.17768412
57PRKCI1.13611512
58MET1.12286457
59ATR1.10086638
60CDK41.07684144
61NEK21.03620499
62PTK2B1.03277661
63ATM1.02940481
64PLK21.02230180
65MAP4K11.01873749
66AURKB1.01053695
67RPS6KB21.00024728
68IRAK10.99823683
69GRK60.99668732
70MELK0.98026031
71NTRK20.97746130
72MKNK20.94692064
73PDK30.93123434
74PDK40.93123434
75AURKA0.91880609
76STK38L0.91489099
77PAK40.89257475
78RPS6KA40.87889809
79NEK10.86560759
80STK40.86337298
81CDK30.85949027
82CLK10.83860190
83DDR20.83525809
84BMPR20.81816451
85MAP2K60.80696110
86IKBKE0.77613430
87CSNK2A20.74227696
88CDK20.72702721
89PASK0.72265111
90DYRK30.68067007
91RPS6KA10.65019572
92CDK70.62469374
93PDGFRB0.61321123
94RIPK40.61321060
95DYRK20.61070965
96MAP3K80.60442110
97CHUK0.60260054
98CDK10.60023267
99EIF2AK20.58199289
100DYRK1A0.57191242
101PIM10.56890715
102PRKDC0.56662988
103TBK10.55709478
104TXK0.55522322
105MKNK10.55257029
106STK30.54685120
107PDK10.54257632
108MAPK120.53991908
109SIK10.53915197
110CAMK2B0.52506877
111CSNK2A10.52495497
112CDK60.52308063
113IRAK20.50215385
114PINK10.50166261
115MAP3K50.49082153
116RET0.48562274
117HCK0.48426888
118RPS6KB10.47732216
119CSNK1E0.46946649
120SGK2230.44742476
121SGK4940.44742476
122SGK20.44627163
123NEK60.42715915
124MINK10.42346761
125STK380.41744513
126ALK0.41427129
127STK100.41116004
128MAPK110.38500131
129DAPK10.37761692
130IKBKB0.37199249
131MARK30.36951492
132RPS6KA50.36085804
133CAMK10.35326622
134STK390.33949361
135MAP2K40.32759538
136ADRBK20.30360462
137GSK3B0.30249632
138IRAK40.29570316
139PDPK10.28896352
140MAPK130.28711912
141CDC42BPA0.28545293
142MAPK100.28026133
143PRKCD0.27974678
144AKT10.23935270
145PAK10.23849091
146TESK20.23627355
147SGK30.23102618
148LATS10.22917141
149FGR0.22682692
150MAPK80.21963907
151CAMK2D0.21725440
152GRK10.21646859
153LCK0.21571701
154EGFR0.21541954
155MAP2K70.21280205
156MAPK40.21147212
157MAPK10.20561801
158MAPK30.19350409
159RPS6KA20.19029048
160CDK50.15767833
161CDK140.15426407
162TRIB30.13559648

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.44100026
2Proteasome_Homo sapiens_hsa030504.67800336
3RNA polymerase_Homo sapiens_hsa030203.77565387
4Ribosome_Homo sapiens_hsa030103.76620157
5DNA replication_Homo sapiens_hsa030303.61747073
6Basal transcription factors_Homo sapiens_hsa030223.56254029
7Mismatch repair_Homo sapiens_hsa034303.48315768
8Homologous recombination_Homo sapiens_hsa034403.41508076
9RNA transport_Homo sapiens_hsa030133.12007942
10Spliceosome_Homo sapiens_hsa030403.03677374
11Fanconi anemia pathway_Homo sapiens_hsa034602.95068925
12Nucleotide excision repair_Homo sapiens_hsa034202.74209155
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.50276662
14One carbon pool by folate_Homo sapiens_hsa006702.41470235
15Cell cycle_Homo sapiens_hsa041102.21906125
16Base excision repair_Homo sapiens_hsa034102.05215800
17Pyrimidine metabolism_Homo sapiens_hsa002402.04398234
18Non-homologous end-joining_Homo sapiens_hsa034502.02768223
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.02041460
20mRNA surveillance pathway_Homo sapiens_hsa030151.98741017
21T cell receptor signaling pathway_Homo sapiens_hsa046601.71905105
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.66988718
23RNA degradation_Homo sapiens_hsa030181.66415661
24N-Glycan biosynthesis_Homo sapiens_hsa005101.63052157
25Legionellosis_Homo sapiens_hsa051341.56264164
26TNF signaling pathway_Homo sapiens_hsa046681.45443373
27MAPK signaling pathway_Homo sapiens_hsa040101.42738598
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40266718
29Measles_Homo sapiens_hsa051621.39983547
30Pentose phosphate pathway_Homo sapiens_hsa000301.37793801
31Purine metabolism_Homo sapiens_hsa002301.36352571
32Estrogen signaling pathway_Homo sapiens_hsa049151.35049334
33Osteoclast differentiation_Homo sapiens_hsa043801.32091908
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29966861
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.28596574
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27739976
37Epstein-Barr virus infection_Homo sapiens_hsa051691.25280296
38Protein export_Homo sapiens_hsa030601.22052884
39Huntingtons disease_Homo sapiens_hsa050161.15381693
40Shigellosis_Homo sapiens_hsa051311.12502215
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10143984
42p53 signaling pathway_Homo sapiens_hsa041151.06237027
43Linoleic acid metabolism_Homo sapiens_hsa005911.04673006
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04117119
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02170459
46Oocyte meiosis_Homo sapiens_hsa041141.00651745
47Regulation of autophagy_Homo sapiens_hsa041400.97933351
48ErbB signaling pathway_Homo sapiens_hsa040120.97295174
49Influenza A_Homo sapiens_hsa051640.97116522
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94395766
51Non-small cell lung cancer_Homo sapiens_hsa052230.93906212
52Systemic lupus erythematosus_Homo sapiens_hsa053220.91050205
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.90530619
54Acute myeloid leukemia_Homo sapiens_hsa052210.89841966
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87370809
56Sulfur relay system_Homo sapiens_hsa041220.86502461
57Toxoplasmosis_Homo sapiens_hsa051450.84787091
58Prolactin signaling pathway_Homo sapiens_hsa049170.84070440
59Ether lipid metabolism_Homo sapiens_hsa005650.82736079
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82285242
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81226941
62Hepatitis B_Homo sapiens_hsa051610.79176498
63Apoptosis_Homo sapiens_hsa042100.78544587
64African trypanosomiasis_Homo sapiens_hsa051430.77678817
65Salmonella infection_Homo sapiens_hsa051320.76018525
66FoxO signaling pathway_Homo sapiens_hsa040680.75663686
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.73425966
68Circadian rhythm_Homo sapiens_hsa047100.72543496
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70693243
70Vitamin B6 metabolism_Homo sapiens_hsa007500.69641747
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68188473
72Arginine and proline metabolism_Homo sapiens_hsa003300.66305225
73Folate biosynthesis_Homo sapiens_hsa007900.63448526
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63345988
75Selenocompound metabolism_Homo sapiens_hsa004500.62386356
76Protein digestion and absorption_Homo sapiens_hsa049740.60920336
77B cell receptor signaling pathway_Homo sapiens_hsa046620.59213637
78ECM-receptor interaction_Homo sapiens_hsa045120.57217078
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.55044982
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54154148
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53660029
82Nicotine addiction_Homo sapiens_hsa050330.52705724
83Herpes simplex infection_Homo sapiens_hsa051680.52700089
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52282847
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51938972
86Lysine degradation_Homo sapiens_hsa003100.50607529
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50583246
88Parkinsons disease_Homo sapiens_hsa050120.49970262
89Oxidative phosphorylation_Homo sapiens_hsa001900.48721738
90Viral carcinogenesis_Homo sapiens_hsa052030.48585032
91Cocaine addiction_Homo sapiens_hsa050300.48192083
92Choline metabolism in cancer_Homo sapiens_hsa052310.47462513
93Prion diseases_Homo sapiens_hsa050200.46808302
94Prostate cancer_Homo sapiens_hsa052150.46130603
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45742935
96mTOR signaling pathway_Homo sapiens_hsa041500.45662288
97Nitrogen metabolism_Homo sapiens_hsa009100.43871813
98Amphetamine addiction_Homo sapiens_hsa050310.41693919
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40447335
100Axon guidance_Homo sapiens_hsa043600.39610021
101Arachidonic acid metabolism_Homo sapiens_hsa005900.39215656
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37733533
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35914223
104Rheumatoid arthritis_Homo sapiens_hsa053230.35776727
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35473452
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.34676435
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34421081
108Sphingolipid metabolism_Homo sapiens_hsa006000.34373509
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34023036
110Fat digestion and absorption_Homo sapiens_hsa049750.33474943
111Caffeine metabolism_Homo sapiens_hsa002320.32386486
112Tight junction_Homo sapiens_hsa045300.31693995
113Biosynthesis of amino acids_Homo sapiens_hsa012300.31683723
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31640011
115Alcoholism_Homo sapiens_hsa050340.31029330
116Arginine biosynthesis_Homo sapiens_hsa002200.31013092
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30958278
118Antigen processing and presentation_Homo sapiens_hsa046120.29696226
119Metabolic pathways_Homo sapiens_hsa011000.29398014
120HTLV-I infection_Homo sapiens_hsa051660.29065146
121Glutathione metabolism_Homo sapiens_hsa004800.26692317
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24534790
123Graft-versus-host disease_Homo sapiens_hsa053320.22902719
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.22617756
125Alzheimers disease_Homo sapiens_hsa050100.22011435
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.20955422
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.20921333
128Mineral absorption_Homo sapiens_hsa049780.17491586
129Renin-angiotensin system_Homo sapiens_hsa046140.14954171
130Ras signaling pathway_Homo sapiens_hsa040140.13019708
131HIF-1 signaling pathway_Homo sapiens_hsa040660.12900062
132Primary immunodeficiency_Homo sapiens_hsa053400.12216871
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12158998
134Histidine metabolism_Homo sapiens_hsa003400.10751556
135Notch signaling pathway_Homo sapiens_hsa043300.10415181
136Glycerolipid metabolism_Homo sapiens_hsa005610.09157324
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.08608073
138Asthma_Homo sapiens_hsa053100.06558243
139Vitamin digestion and absorption_Homo sapiens_hsa049770.06024909
140Fructose and mannose metabolism_Homo sapiens_hsa000510.04914625
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.04847399
142Cardiac muscle contraction_Homo sapiens_hsa042600.04270760
143Long-term depression_Homo sapiens_hsa047300.04253793
144Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.04248919
145PI3K-Akt signaling pathway_Homo sapiens_hsa041510.04103245
146Pancreatic secretion_Homo sapiens_hsa049720.02680676
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.02584963
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.01279726
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.00684544
150Glucagon signaling pathway_Homo sapiens_hsa049220.00048749
151Pathways in cancer_Homo sapiens_hsa05200-0.0022413

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