HYAL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.88787539
2L-phenylalanine catabolic process (GO:0006559)6.88787539
3exogenous drug catabolic process (GO:0042738)6.79812439
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.57361360
5L-phenylalanine metabolic process (GO:0006558)6.57361360
6aromatic amino acid family catabolic process (GO:0009074)6.40946272
7drug catabolic process (GO:0042737)6.35015809
8tryptophan catabolic process (GO:0006569)6.07502295
9indole-containing compound catabolic process (GO:0042436)6.07502295
10indolalkylamine catabolic process (GO:0046218)6.07502295
11intestinal cholesterol absorption (GO:0030299)5.73971158
12tryptophan metabolic process (GO:0006568)5.72039610
13epoxygenase P450 pathway (GO:0019373)5.71677810
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.71184389
15kynurenine metabolic process (GO:0070189)5.69067228
16regulation of plasminogen activation (GO:0010755)5.65931991
17complement activation, alternative pathway (GO:0006957)5.54842074
18bile acid biosynthetic process (GO:0006699)5.52086787
19regulation of protein activation cascade (GO:2000257)5.36216696
20glyoxylate metabolic process (GO:0046487)5.22870104
21alpha-linolenic acid metabolic process (GO:0036109)5.22015026
22urea metabolic process (GO:0019627)5.19677529
23urea cycle (GO:0000050)5.19677529
24regulation of complement activation (GO:0030449)5.08455600
25omega-hydroxylase P450 pathway (GO:0097267)5.04601362
26protein carboxylation (GO:0018214)5.03159441
27peptidyl-glutamic acid carboxylation (GO:0017187)5.03159441
28sulfur amino acid catabolic process (GO:0000098)5.02492486
29negative regulation of protein activation cascade (GO:2000258)4.91865506
30negative regulation of fibrinolysis (GO:0051918)4.91703014
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.88252660
32regulation of fibrinolysis (GO:0051917)4.85885281
33high-density lipoprotein particle remodeling (GO:0034375)4.84627558
34cysteine metabolic process (GO:0006534)4.82521063
35tyrosine metabolic process (GO:0006570)4.80902431
36serine family amino acid catabolic process (GO:0009071)4.78781467
37homocysteine metabolic process (GO:0050667)4.76379270
38aromatic amino acid family metabolic process (GO:0009072)4.75526050
39nitrogen cycle metabolic process (GO:0071941)4.74585449
40negative regulation of blood coagulation (GO:0030195)4.67820542
41negative regulation of hemostasis (GO:1900047)4.67820542
42bile acid metabolic process (GO:0008206)4.67319223
43regulation of triglyceride catabolic process (GO:0010896)4.61580979
44amino-acid betaine metabolic process (GO:0006577)4.55959987
45regulation of cholesterol esterification (GO:0010872)4.46910596
46alpha-amino acid catabolic process (GO:1901606)4.44718651
47cellular biogenic amine catabolic process (GO:0042402)4.42010836
48amine catabolic process (GO:0009310)4.42010836
49plasma lipoprotein particle remodeling (GO:0034369)4.34828875
50protein-lipid complex remodeling (GO:0034368)4.34828875
51macromolecular complex remodeling (GO:0034367)4.34828875
52lysine metabolic process (GO:0006553)4.34680073
53lysine catabolic process (GO:0006554)4.34680073
54reverse cholesterol transport (GO:0043691)4.34625654
55triglyceride homeostasis (GO:0070328)4.34124948
56acylglycerol homeostasis (GO:0055090)4.34124948
57plasma lipoprotein particle organization (GO:0071827)4.33952838
58drug metabolic process (GO:0017144)4.30642842
59negative regulation of coagulation (GO:0050819)4.30346775
60coenzyme catabolic process (GO:0009109)4.29040650
61indolalkylamine metabolic process (GO:0006586)4.28678996
62acute-phase response (GO:0006953)4.27576705
63regulation of humoral immune response (GO:0002920)4.26156915
64protein-lipid complex assembly (GO:0065005)4.24195763
65positive regulation of blood coagulation (GO:0030194)4.23626354
66positive regulation of hemostasis (GO:1900048)4.23626354
67negative regulation of complement activation (GO:0045916)4.19266780
68phospholipid efflux (GO:0033700)4.18747391
69regulation of apoptotic cell clearance (GO:2000425)4.18598850
70imidazole-containing compound metabolic process (GO:0052803)4.15454521
71negative regulation of wound healing (GO:0061045)4.12364967
72cellular modified amino acid catabolic process (GO:0042219)4.11230682
73oxidative demethylation (GO:0070989)4.10754793
74cellular glucuronidation (GO:0052695)4.06795335
75protein-lipid complex subunit organization (GO:0071825)4.06362026
76cellular amino acid catabolic process (GO:0009063)4.05967950
77bile acid and bile salt transport (GO:0015721)4.05622696
78low-density lipoprotein particle remodeling (GO:0034374)4.05563712
79plasma lipoprotein particle clearance (GO:0034381)4.04386784
80cellular ketone body metabolic process (GO:0046950)4.01274006
81ethanol metabolic process (GO:0006067)3.95847823
82ethanol oxidation (GO:0006069)3.93510692
83negative regulation of cholesterol transport (GO:0032375)3.91971684
84negative regulation of sterol transport (GO:0032372)3.91971684
85glycine metabolic process (GO:0006544)3.90735702
86fibrinolysis (GO:0042730)3.90408460
87positive regulation of coagulation (GO:0050820)3.85319186
88short-chain fatty acid metabolic process (GO:0046459)3.84851448
89benzene-containing compound metabolic process (GO:0042537)3.81893341
90phenylpropanoid metabolic process (GO:0009698)3.81518017
91cholesterol efflux (GO:0033344)3.79927254
92glutamate metabolic process (GO:0006536)3.79312123
93complement activation (GO:0006956)3.77444873
94very-low-density lipoprotein particle assembly (GO:0034379)3.76886869
95serine family amino acid metabolic process (GO:0009069)3.76405700
96arginine metabolic process (GO:0006525)3.74278267
97protein activation cascade (GO:0072376)3.72956673
98plasma lipoprotein particle assembly (GO:0034377)3.72755739
99ketone body metabolic process (GO:1902224)3.70582090
100negative regulation of lipase activity (GO:0060192)3.70512394
101complement activation, classical pathway (GO:0006958)3.67059591
102blood coagulation, intrinsic pathway (GO:0007597)3.66830653
103cytolysis (GO:0019835)3.63824206
104organic acid catabolic process (GO:0016054)3.63055831
105carboxylic acid catabolic process (GO:0046395)3.63055831
106flavonoid metabolic process (GO:0009812)3.62946439
107cofactor catabolic process (GO:0051187)3.62389936
108phospholipid homeostasis (GO:0055091)3.60297838
109regulation of bile acid biosynthetic process (GO:0070857)3.60202347
110positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.58436333
111lipoprotein metabolic process (GO:0042157)3.57696571
112positive regulation of fatty acid biosynthetic process (GO:0045723)3.57664804
113fatty acid beta-oxidation (GO:0006635)3.56948514
114NAD biosynthetic process (GO:0009435)3.55951510
115acetyl-CoA metabolic process (GO:0006084)3.55843243
116glucuronate metabolic process (GO:0019585)3.55558227
117uronic acid metabolic process (GO:0006063)3.55558227
118dicarboxylic acid biosynthetic process (GO:0043650)3.52545958
119carnitine metabolic process (GO:0009437)3.52221419
120aldehyde catabolic process (GO:0046185)3.51928040
121response to mercury ion (GO:0046689)3.51805298
122fatty acid oxidation (GO:0019395)3.51110617
123regulation of cholesterol homeostasis (GO:2000188)3.50520181
124positive regulation of lipid catabolic process (GO:0050996)3.49774848
125drug transmembrane transport (GO:0006855)3.49194035
126serine family amino acid biosynthetic process (GO:0009070)3.48842437
127cholesterol homeostasis (GO:0042632)3.47572387
128lipid oxidation (GO:0034440)3.47470443
129positive regulation of lipoprotein lipase activity (GO:0051006)3.47288474
130positive regulation of triglyceride lipase activity (GO:0061365)3.47288474
131intestinal absorption (GO:0050892)3.46334035
132positive regulation of fatty acid beta-oxidation (GO:0032000)3.44586452
133proline metabolic process (GO:0006560)3.44193509
134nicotinamide nucleotide biosynthetic process (GO:0019359)3.44003444
135fat-soluble vitamin biosynthetic process (GO:0042362)3.41679621
136sterol transport (GO:0015918)3.40704301
137cholesterol transport (GO:0030301)3.40704301
138sterol homeostasis (GO:0055092)3.40321823
139S-adenosylmethionine metabolic process (GO:0046500)3.38840135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.84814832
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.94187884
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.72785143
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.09638909
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.31911227
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.03128676
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.80500189
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.86924839
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.60803625
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11512527
11* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9010061
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97671194
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.80434063
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.73119763
15TP63_17297297_ChIP-ChIP_HaCaT_Human1.66814617
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65919476
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65688218
18GATA1_22025678_ChIP-Seq_K562_Human1.63983393
19CLOCK_20551151_ChIP-Seq_293T_Human1.57649988
20ZNF263_19887448_ChIP-Seq_K562_Human1.55635477
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53271428
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52400704
23* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42240823
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.42226105
25HTT_18923047_ChIP-ChIP_STHdh_Human1.37757220
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36300810
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31230342
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.31218458
29* HNF4A_19822575_ChIP-Seq_HepG2_Human1.26381188
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25346730
31RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16320234
32GATA6_25053715_ChIP-Seq_YYC3_Human1.11021027
33ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10288000
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.09432775
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08441699
36CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02713812
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96740563
38TCF4_18268006_ChIP-ChIP_LS174T_Human0.95099760
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95036464
40ESR2_21235772_ChIP-Seq_MCF-7_Human0.94617065
41ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94594592
42RAC3_21632823_ChIP-Seq_H3396_Human0.92572972
43GATA4_25053715_ChIP-Seq_YYC3_Human0.91971832
44TRIM28_21343339_ChIP-Seq_HEK293_Human0.90924537
45SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88658892
46CDX2_20551321_ChIP-Seq_CACO-2_Human0.86568223
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85913819
48NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85913819
49SOX2_21211035_ChIP-Seq_LN229_Human0.85456363
50* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82704505
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.82402444
52LXR_22292898_ChIP-Seq_THP-1_Human0.82371154
53SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82293713
54PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82125842
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82062091
56KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80357562
57SMC4_20622854_ChIP-Seq_HELA_Human0.80303931
58HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79975383
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79577805
60BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79528644
61SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78969527
62AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78625447
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.77801661
64STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.76186941
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.75252160
66NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.73439124
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72623823
68DNAJC2_21179169_ChIP-ChIP_NT2_Human0.69495812
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69319872
70OCT4_20526341_ChIP-Seq_ESCs_Human0.69202024
71MYC_19829295_ChIP-Seq_ESCs_Human0.68608336
72EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.68316835
73* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.68034130
74P63_26484246_Chip-Seq_KERATINOCYTES_Human0.67771763
75RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67531443
76P53_21459846_ChIP-Seq_SAOS-2_Human0.67122048
77CTCF_27219007_Chip-Seq_Bcells_Human0.66728462
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.65997691
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.64795423
80AR_20517297_ChIP-Seq_VCAP_Human0.64577256
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64051922
82PPAR_26484153_Chip-Seq_NCI-H1993_Human0.63469993
83* E2F1_20622854_ChIP-Seq_HELA_Human0.62538586
84PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.62531033
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.61719375
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.60948488
87SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.60636203
88* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59867945
89FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.59851241
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.59540415
91IRF1_19129219_ChIP-ChIP_H3396_Human0.59214460
92NFIB_24661679_ChIP-Seq_LUNG_Mouse0.58838335
93ERA_21632823_ChIP-Seq_H3396_Human0.58352713
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.57978581
95RARA_24833708_ChIP-Seq_LIVER_Mouse0.57952753
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57825133
97FOXH1_21741376_ChIP-Seq_ESCs_Human0.57558502
98ERG_21242973_ChIP-ChIP_JURKAT_Human0.57296469
99* CEBPB_22108803_ChIP-Seq_LS180_Human0.57063788
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.56667915
101TP53_16413492_ChIP-PET_HCT116_Human0.56003867
102GATA2_21666600_ChIP-Seq_HMVEC_Human0.55664433
103SOX2_20726797_ChIP-Seq_SW620_Human0.55346458
104* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.55163522
105SOX11_22085726_ChIP-Seq_ESNs_Mouse0.54920263
106* SPI1_20517297_ChIP-Seq_HL60_Human0.54742877
107SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.54553933
108* P68_20966046_ChIP-Seq_HELA_Human0.53526797
109STAT1_17558387_ChIP-Seq_HELA_Human0.53508685
110BCAT_22108803_ChIP-Seq_LS180_Human0.53288406
111STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53286774
112GATA3_24758297_ChIP-Seq_MCF-7_Human0.53228530
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.52272624
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.52193666
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.51980619
116FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51936661
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.51091473
118IRF8_27001747_Chip-Seq_BMDM_Mouse0.50093171
119PIAS1_25552417_ChIP-Seq_VCAP_Human0.49908264
120SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.49290625
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.49100668
122RARB_24833708_ChIP-Seq_LIVER_Mouse0.48995568
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.48845752
124CBP_21632823_ChIP-Seq_H3396_Human0.48329077
125SOX9_24532713_ChIP-Seq_HFSC_Mouse0.48276143
126LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.48051651
127FOXA1_25552417_ChIP-Seq_VCAP_Human0.46162380
128ESET_19884257_ChIP-Seq_ESCs_Mouse0.45985091
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.44461880
130CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.44321783
131EGR1_19032775_ChIP-ChIP_M12_Human0.44084123
132SUZ12_27294783_Chip-Seq_NPCs_Mouse0.43719468
133CJUN_26792858_Chip-Seq_BT549_Human0.43254907
134EZH2_27294783_Chip-Seq_NPCs_Mouse0.42810174
135CSB_26484114_Chip-Seq_FIBROBLAST_Human0.42664299
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.42397353
137NFE2_27457419_Chip-Seq_LIVER_Mouse0.42223271
138CRX_20693478_ChIP-Seq_RETINA_Mouse0.41718762
139IRF8_21731497_ChIP-ChIP_J774_Mouse0.41196399
140GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.40762257

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.53372194
2MP0005360_urolithiasis6.78601978
3MP0005085_abnormal_gallbladder_physiolo5.99087331
4MP0005365_abnormal_bile_salt5.70605739
5MP0008875_abnormal_xenobiotic_pharmacok4.78270600
6MP0003252_abnormal_bile_duct4.32481934
7MP0003806_abnormal_nucleotide_metabolis3.52251002
8MP0010329_abnormal_lipoprotein_level3.36073640
9MP0005083_abnormal_biliary_tract3.10206547
10MP0009840_abnormal_foam_cell2.87482534
11MP0003195_calcinosis2.71994584
12MP0005332_abnormal_amino_acid2.68936781
13MP0001666_abnormal_nutrient_absorption2.29427550
14MP0003191_abnormal_cellular_cholesterol2.22138127
15MP0004019_abnormal_vitamin_homeostasis2.21785216
16MP0000609_abnormal_liver_physiology2.10434156
17MP0002118_abnormal_lipid_homeostasis2.02458321
18MP0002138_abnormal_hepatobiliary_system2.01567535
19MP0002254_reproductive_system_inflammat1.97087663
20MP0003011_delayed_dark_adaptation1.86276283
21MP0005670_abnormal_white_adipose1.85629553
22MP0003122_maternal_imprinting1.75095359
23MP0005319_abnormal_enzyme/_coenzyme1.74302022
24MP0001764_abnormal_homeostasis1.63929485
25MP0009697_abnormal_copulation1.56032178
26MP0003868_abnormal_feces_composition1.53776339
27MP0004381_abnormal_hair_follicle1.40518269
28MP0003186_abnormal_redox_activity1.39019920
29MP0009764_decreased_sensitivity_to1.37739322
30MP0005584_abnormal_enzyme/coenzyme_acti1.34465609
31MP0005451_abnormal_body_composition1.31005037
32MP0005647_abnormal_sex_gland1.30083199
33MP0009643_abnormal_urine_homeostasis1.22692022
34MP0002089_abnormal_postnatal_growth/wei1.15547285
35* MP0000598_abnormal_liver_morphology1.12091245
36MP0009763_increased_sensitivity_to1.09652607
37MP0005408_hypopigmentation1.09098411
38MP0001915_intracranial_hemorrhage1.04093895
39MP0005084_abnormal_gallbladder_morpholo1.03344022
40MP0003656_abnormal_erythrocyte_physiolo0.95210713
41MP0010368_abnormal_lymphatic_system0.94983361
42MP0003705_abnormal_hypodermis_morpholog0.93793424
43MP0008469_abnormal_protein_level0.92388818
44MP0003879_abnormal_hair_cell0.87445399
45MP0000604_amyloidosis0.87033322
46MP0005220_abnormal_exocrine_pancreas0.85708322
47MP0002971_abnormal_brown_adipose0.85434344
48MP0003724_increased_susceptibility_to0.84454015
49MP0002928_abnormal_bile_duct0.82427912
50MP0005330_cardiomyopathy0.80713768
51MP0009642_abnormal_blood_homeostasis0.79604449
52MP0002060_abnormal_skin_morphology0.78526228
53MP0005334_abnormal_fat_pad0.77890849
54MP0009765_abnormal_xenobiotic_induced0.75599713
55MP0003646_muscle_fatigue0.75406864
56MP0005636_abnormal_mineral_homeostasis0.74717667
57MP0003436_decreased_susceptibility_to0.74699934
58MP0002796_impaired_skin_barrier0.74680093
59MP0002876_abnormal_thyroid_physiology0.74557274
60MP0005376_homeostasis/metabolism_phenot0.74554404
61MP0001661_extended_life_span0.73884904
62MP0005248_abnormal_Harderian_gland0.73392675
63MP0005075_abnormal_melanosome_morpholog0.68976180
64MP0004130_abnormal_muscle_cell0.67730694
65MP0009384_cardiac_valve_regurgitation0.66732105
66MP0004782_abnormal_surfactant_physiolog0.65893569
67MP0005377_hearing/vestibular/ear_phenot0.64160906
68MP0003878_abnormal_ear_physiology0.64160906
69MP0003690_abnormal_glial_cell0.63916398
70MP0002078_abnormal_glucose_homeostasis0.63009174
71MP0002282_abnormal_trachea_morphology0.61119310
72MP0005666_abnormal_adipose_tissue0.60993969
73MP0003172_abnormal_lysosome_physiology0.60471171
74MP0001853_heart_inflammation0.59025400
75MP0008438_abnormal_cutaneous_collagen0.57499410
76MP0005464_abnormal_platelet_physiology0.56216844
77MP0005409_darkened_coat_color0.56072127
78MP0006036_abnormal_mitochondrial_physio0.55485550
79MP0002136_abnormal_kidney_physiology0.54962388
80MP0005395_other_phenotype0.54777937
81MP0003950_abnormal_plasma_membrane0.54401798
82MP0002269_muscular_atrophy0.54195183
83MP0000579_abnormal_nail_morphology0.53960449
84MP0003453_abnormal_keratinocyte_physiol0.53272176
85MP0005167_abnormal_blood-brain_barrier0.51032338
86MP0003718_maternal_effect0.50388181
87MP0000003_abnormal_adipose_tissue0.49637709
88MP0001243_abnormal_dermal_layer0.49380577
89MP0005058_abnormal_lysosome_morphology0.49301900
90MP0005164_abnormal_response_to0.48486351
91MP0004272_abnormal_basement_membrane0.48483063
92MP0009115_abnormal_fat_cell0.48310734
93MP0001756_abnormal_urination0.48235771
94MP0003300_gastrointestinal_ulcer0.48042110
95MP0004043_abnormal_pH_regulation0.47302791
96MP0005535_abnormal_body_temperature0.46917193
97MP0005551_abnormal_eye_electrophysiolog0.46606129
98MP0000566_synostosis0.45616485
99MP0001324_abnormal_eye_pigmentation0.44876419
100MP0002909_abnormal_adrenal_gland0.44656426
101MP0001881_abnormal_mammary_gland0.44466286
102MP0003638_abnormal_response/metabolism_0.43760100
103MP0002249_abnormal_larynx_morphology0.43752748
104MP0002098_abnormal_vibrissa_morphology0.43218956
105MP0006082_CNS_inflammation0.43098119
106MP0003567_abnormal_fetal_cardiomyocyte0.43068969
107MP0008872_abnormal_physiological_respon0.42138875
108MP0004883_abnormal_blood_vessel0.41483107
109MP0005595_abnormal_vascular_smooth0.41414080
110MP0002168_other_aberrant_phenotype0.40966113
111MP0000249_abnormal_blood_vessel0.40568252
112MP0003123_paternal_imprinting0.40491428
113MP0003953_abnormal_hormone_level0.40327193
114MP0000371_diluted_coat_color0.40114241
115MP0002132_abnormal_respiratory_system0.39520080
116MP0005266_abnormal_metabolism0.39227501
117MP0000013_abnormal_adipose_tissue0.37782247
118MP0009780_abnormal_chondrocyte_physiolo0.37244639
119MP0010630_abnormal_cardiac_muscle0.37221132
120MP0005197_abnormal_uvea_morphology0.36747675
121MP0000467_abnormal_esophagus_morphology0.36566941
122MP0005448_abnormal_energy_balance0.35951594
123MP0000639_abnormal_adrenal_gland0.35915806
124MP0005501_abnormal_skin_physiology0.35456042
125MP0005275_abnormal_skin_tensile0.35429643
126MP0005410_abnormal_fertilization0.34200175
127MP0000751_myopathy0.33703784
128MP0008775_abnormal_heart_ventricle0.33534192
129MP0005187_abnormal_penis_morphology0.32582732
130MP0006138_congestive_heart_failure0.32079759
131MP0004087_abnormal_muscle_fiber0.31486845

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.95910246
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.64226650
3Deep venous thrombosis (HP:0002625)6.56789521
4Prolonged partial thromboplastin time (HP:0003645)6.33221945
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.27181607
6Xanthomatosis (HP:0000991)6.03350628
7Complement deficiency (HP:0004431)5.58271944
8Hypobetalipoproteinemia (HP:0003563)5.49666071
9Hyperlipoproteinemia (HP:0010980)5.35873038
10Joint hemorrhage (HP:0005261)4.96799878
11Hyperammonemia (HP:0001987)4.54296377
12Hyperglycinuria (HP:0003108)4.54013918
13Hyperglycinemia (HP:0002154)4.45026516
14Epidermoid cyst (HP:0200040)4.44258986
15Hypolipoproteinemia (HP:0010981)4.36183384
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.29589890
17Abnormality of methionine metabolism (HP:0010901)4.28953399
18Abnormality of glycine metabolism (HP:0010895)4.23525184
19Abnormality of serine family amino acid metabolism (HP:0010894)4.23525184
20Abnormality of complement system (HP:0005339)4.15871894
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.13094622
22Abnormality of sulfur amino acid metabolism (HP:0004339)4.10782770
23Hypoalphalipoproteinemia (HP:0003233)4.09232092
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.08701470
25Abnormality of the common coagulation pathway (HP:0010990)4.07942553
26Ketosis (HP:0001946)3.98604380
27Fat malabsorption (HP:0002630)3.84392703
28Abnormality of pyrimidine metabolism (HP:0004353)3.82125656
29Conjugated hyperbilirubinemia (HP:0002908)3.81684730
30Hypoglycemic coma (HP:0001325)3.73756823
31Hypercholesterolemia (HP:0003124)3.61359230
32Abnormality of fatty-acid metabolism (HP:0004359)3.47394049
33Abnormality of the intrinsic pathway (HP:0010989)3.45975978
34Myocardial infarction (HP:0001658)3.42814022
35Systemic lupus erythematosus (HP:0002725)3.27198659
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.23299895
37Abnormality of serum amino acid levels (HP:0003112)3.10695122
38Hyperbilirubinemia (HP:0002904)3.07145586
39Steatorrhea (HP:0002570)3.00386955
40Hepatocellular carcinoma (HP:0001402)2.90955850
41Abnormality of nucleobase metabolism (HP:0010932)2.89773924
42Delayed CNS myelination (HP:0002188)2.84303646
43Abnormality of dicarboxylic acid metabolism (HP:0010995)2.82712625
44Dicarboxylic aciduria (HP:0003215)2.82712625
45Ketoacidosis (HP:0001993)2.80006054
46Vascular calcification (HP:0004934)2.79419060
47Glomerulonephritis (HP:0000099)2.74262919
48Retinal atrophy (HP:0001105)2.71996780
49Spontaneous abortion (HP:0005268)2.66069960
50Metabolic acidosis (HP:0001942)2.65516227
51Skin nodule (HP:0200036)2.64692150
52Abnormality of proline metabolism (HP:0010907)2.63853094
53Hydroxyprolinuria (HP:0003080)2.63853094
54Purpura (HP:0000979)2.60326751
55Hypochromic microcytic anemia (HP:0004840)2.59985632
56Lethargy (HP:0001254)2.57936321
57Amyloidosis (HP:0011034)2.55341422
58Recurrent gram-negative bacterial infections (HP:0005420)2.50930207
59Arthropathy (HP:0003040)2.50428462
60Cardiovascular calcification (HP:0011915)2.49570294
61Gingival bleeding (HP:0000225)2.48902519
62Esophageal varix (HP:0002040)2.46246711
63Hypoglycemic seizures (HP:0002173)2.45276946
64Abnormality of purine metabolism (HP:0004352)2.43598058
65Abnormal gallbladder physiology (HP:0012438)2.42219185
66Cholecystitis (HP:0001082)2.42219185
67Enlarged kidneys (HP:0000105)2.39129425
68Increased serum pyruvate (HP:0003542)2.35123960
69Mitral stenosis (HP:0001718)2.32950492
70Spastic diplegia (HP:0001264)2.30972246
71Generalized aminoaciduria (HP:0002909)2.25688590
72Menorrhagia (HP:0000132)2.22905952
73Renal cortical cysts (HP:0000803)2.22182018
74Pancreatitis (HP:0001733)2.20636740
75Osteomalacia (HP:0002749)2.18711241
76Abnormal tarsal ossification (HP:0008369)2.18625607
77Neonatal onset (HP:0003623)2.09050180
78Sensorimotor neuropathy (HP:0007141)2.08726046
79Abnormality of glycolysis (HP:0004366)2.07837528
80Rickets (HP:0002748)2.07172563
81Opisthotonus (HP:0002179)2.06647030
82Poikilocytosis (HP:0004447)2.06208236
83Reduced antithrombin III activity (HP:0001976)2.05645522
84Nephritis (HP:0000123)2.03928047
85Cerebral edema (HP:0002181)2.03485632
86Irritability (HP:0000737)2.00797623
87Vomiting (HP:0002013)2.00436764
88Abnormal gallbladder morphology (HP:0012437)2.00329687
89Hemorrhage of the eye (HP:0011885)1.99983202
90Acanthocytosis (HP:0001927)1.98567790
91Abnormality of carpal bone ossification (HP:0006257)1.98018749
92Abnormality of the Achilles tendon (HP:0005109)1.97161527
93Abnormal enzyme/coenzyme activity (HP:0012379)1.93729738
94Malnutrition (HP:0004395)1.92930894
95Hypertriglyceridemia (HP:0002155)1.92856700
96Thrombophlebitis (HP:0004418)1.92598094
97Cholelithiasis (HP:0001081)1.92476310
98Gout (HP:0001997)1.91888048
99Brushfield spots (HP:0001088)1.91290113
100Hypophosphatemic rickets (HP:0004912)1.90023743
101Late onset (HP:0003584)1.89710000
102Bifid scrotum (HP:0000048)1.89534777
103Abnormality of iron homeostasis (HP:0011031)1.89337702
104Pulmonary embolism (HP:0002204)1.89254994
105Elevated hepatic transaminases (HP:0002910)1.89137299
106Pancreatic islet-cell hyperplasia (HP:0004510)1.88666956
107Abnormality of transition element cation homeostasis (HP:0011030)1.85684109
108Glycosuria (HP:0003076)1.85434701
109Abnormality of urine glucose concentration (HP:0011016)1.85434701
110Hyperinsulinemic hypoglycemia (HP:0000825)1.84457642
111Fair hair (HP:0002286)1.81896903
112Facial shape deformation (HP:0011334)1.80055885
113Potter facies (HP:0002009)1.80055885
114Abnormality of vitamin metabolism (HP:0100508)1.77351936
115Bile duct proliferation (HP:0001408)1.77016863
116Abnormal biliary tract physiology (HP:0012439)1.77016863
117Nausea (HP:0002018)1.76648385
118Elevated alkaline phosphatase (HP:0003155)1.75585004
119Alkalosis (HP:0001948)1.73626051
120Hyperphosphaturia (HP:0003109)1.71581310
121Proximal tubulopathy (HP:0000114)1.69715913
122Abnormality of alkaline phosphatase activity (HP:0004379)1.68704403
123Abnormality of the nasal septum (HP:0000419)1.57655018
124Broad alveolar ridges (HP:0000187)1.52767264
125Joint swelling (HP:0001386)1.51017256
126Abnormal urine phosphate concentration (HP:0012599)1.49352492
127Vaginal fistula (HP:0004320)1.48710712
128Neoplasm of the liver (HP:0002896)1.47144452
129Glomerulosclerosis (HP:0000096)1.46488413
130Gangrene (HP:0100758)1.46484240
131Increased serum ferritin (HP:0003281)1.46257210

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.41090995
2SIK13.98017959
3WNK43.80399205
4ERN13.61638408
5FGFR43.59442276
6MST1R3.08440370
7ICK2.94179853
8INSRR2.73986059
9TAOK32.66209620
10STK38L2.46983673
11ERBB42.45762234
12IRAK32.38713105
13SIK22.16098056
14PDK22.06331777
15PIK3CG2.02403327
16TGFBR21.98478500
17MAP3K141.91509819
18TIE11.74124249
19OBSCN1.62415692
20ADRBK21.61818958
21TYK21.60739373
22LATS11.58811145
23NUAK11.54108767
24MAP3K71.48174001
25MAPK111.47900355
26KDR1.46608774
27FGFR11.44260158
28NTRK31.36560673
29STK391.35359288
30FLT31.30852650
31CAMK1D1.28984154
32ZAK1.28842313
33PIK3CA1.27030327
34MET1.26647086
35PDPK11.26431011
36TBK11.25031295
37MAPKAPK31.23768695
38EPHA21.23393221
39NEK11.20393726
40NEK91.19602041
41PRKAA21.17729899
42EPHA31.17361377
43CDK121.14096744
44MAP2K31.13513088
45IKBKE1.13287326
46PTK61.07994810
47GRK11.04064561
48WNK31.03612363
49MAP3K31.03344180
50EIF2AK11.02656201
51MAP2K41.01284037
52MAPK151.00149709
53CDK60.99260108
54ABL20.98932342
55ERBB20.97303316
56JAK10.95147591
57BLK0.92395494
58MYLK0.91942502
59MAPK70.91079311
60MAP3K20.89479451
61JAK20.88668030
62MAP4K20.88010223
63PKN20.87766563
64TYRO30.85295743
65RET0.85017721
66PBK0.84327008
67KIT0.84167657
68WNK10.83513631
69EIF2AK20.81674205
70DYRK1B0.80247730
71TRIB30.79775464
72GSK3A0.79658278
73MUSK0.79226872
74CSK0.78557091
75PKN10.77597351
76SGK2230.77044297
77SGK4940.77044297
78STK160.76349381
79MAPK40.75739454
80PDK10.75518724
81AKT30.74505007
82IKBKB0.71218468
83PDGFRA0.70604680
84PINK10.69561635
85BMX0.68279739
86MAPK120.68034103
87MARK30.67062977
88BCR0.66702279
89EPHB20.65480213
90BRD40.65217433
91FGFR20.64946529
92RIPK10.63861676
93EEF2K0.62928954
94FGFR30.62842145
95TEC0.61440434
96PRKACA0.60929713
97CSNK1D0.59906197
98CHUK0.59645237
99FRK0.59243302
100PHKG20.58316630
101PHKG10.58316630
102PRKCG0.57608432
103LMTK20.57126306
104IRAK10.56594797
105SGK10.55489496
106CSNK1E0.55485433
107PRKG10.53737465
108MAP2K60.53527743
109BRSK20.53137548
110PRKD20.52818030
111PRKG20.52533517
112CAMK2G0.52273617
113CDK70.51141274
114PRKACG0.51082132
115SGK30.50803301
116NLK0.50672392
117TAOK20.49908768
118CSF1R0.48743984
119SGK20.48609666
120IGF1R0.48177234
121CDK40.47968982
122NEK20.46582349
123PRKCZ0.46197116
124MAP2K20.45999261
125STK380.45779633
126ABL10.44968591
127TTN0.43485979
128IRAK20.43410478
129CAMKK20.42178025
130IRAK40.41611581
131CAMK40.41483871
132EPHA40.41053277
133RPS6KA30.38989765
134EPHB10.38379625
135GRK70.38023685
136DAPK20.36009315
137PRKAA10.35850939
138SRC0.35462651
139RPS6KB10.35390804
140STK30.34388500
141MAP2K10.32172991
142MAP3K10.31962412
143MTOR0.31860394
144AKT20.31768709
145MAP3K50.31643098
146MAPK30.31154879
147CAMK1G0.29816584
148FER0.28944241
149PRKCH0.28836232
150PRKCQ0.27920169
151JAK30.25391958

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.30593902
2Nitrogen metabolism_Homo sapiens_hsa009103.23838590
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10584373
4Complement and coagulation cascades_Homo sapiens_hsa046102.84100572
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.79470571
6Arginine biosynthesis_Homo sapiens_hsa002202.78733481
7Tryptophan metabolism_Homo sapiens_hsa003802.70077284
8Fatty acid degradation_Homo sapiens_hsa000712.68723022
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55973220
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51668911
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44141750
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38693637
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28155602
14Peroxisome_Homo sapiens_hsa041462.23441303
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16698599
16Butanoate metabolism_Homo sapiens_hsa006502.07524449
17PPAR signaling pathway_Homo sapiens_hsa033202.02979201
18Staphylococcus aureus infection_Homo sapiens_hsa051502.02770047
19Fatty acid metabolism_Homo sapiens_hsa012122.01008609
20Propanoate metabolism_Homo sapiens_hsa006401.99361321
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98416929
22Chemical carcinogenesis_Homo sapiens_hsa052041.97728405
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.97539542
24Histidine metabolism_Homo sapiens_hsa003401.89694660
25Retinol metabolism_Homo sapiens_hsa008301.86137761
26beta-Alanine metabolism_Homo sapiens_hsa004101.85079396
27Caffeine metabolism_Homo sapiens_hsa002321.83244767
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.82009345
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.67855361
30Tyrosine metabolism_Homo sapiens_hsa003501.66759948
31Phenylalanine metabolism_Homo sapiens_hsa003601.57014215
32Fatty acid elongation_Homo sapiens_hsa000621.51874803
33Selenocompound metabolism_Homo sapiens_hsa004501.50877092
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46950340
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.44744558
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43712340
37Bile secretion_Homo sapiens_hsa049761.38724128
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36494170
39ABC transporters_Homo sapiens_hsa020101.30402033
40Starch and sucrose metabolism_Homo sapiens_hsa005001.29331142
41Pyruvate metabolism_Homo sapiens_hsa006201.29192923
42Steroid biosynthesis_Homo sapiens_hsa001001.25451784
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17831290
44Sulfur metabolism_Homo sapiens_hsa009201.16852153
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13929137
46Folate biosynthesis_Homo sapiens_hsa007901.13656778
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.08962290
48Carbon metabolism_Homo sapiens_hsa012001.07593267
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07049840
50Fat digestion and absorption_Homo sapiens_hsa049751.06703234
51Biosynthesis of amino acids_Homo sapiens_hsa012301.04247475
52Arginine and proline metabolism_Homo sapiens_hsa003301.03696897
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.02008750
54Vitamin digestion and absorption_Homo sapiens_hsa049771.00359574
55Sulfur relay system_Homo sapiens_hsa041220.98555809
56Lysine degradation_Homo sapiens_hsa003100.93489793
57Vitamin B6 metabolism_Homo sapiens_hsa007500.93132984
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.92567733
59One carbon pool by folate_Homo sapiens_hsa006700.90960675
60Fatty acid biosynthesis_Homo sapiens_hsa000610.82702641
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75616150
62Glutathione metabolism_Homo sapiens_hsa004800.70992465
63Glycerolipid metabolism_Homo sapiens_hsa005610.67577652
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54897084
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49697224
66* Metabolic pathways_Homo sapiens_hsa011000.49643172
67Pentose phosphate pathway_Homo sapiens_hsa000300.49096897
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42909656
69Linoleic acid metabolism_Homo sapiens_hsa005910.40278065
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31477912
71Galactose metabolism_Homo sapiens_hsa000520.27852015
72Prion diseases_Homo sapiens_hsa050200.26686934
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.23968087
74Insulin resistance_Homo sapiens_hsa049310.21912747
75Arachidonic acid metabolism_Homo sapiens_hsa005900.19684640
76Fructose and mannose metabolism_Homo sapiens_hsa000510.19129095
77Mineral absorption_Homo sapiens_hsa049780.18858268
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.17723796
79Circadian rhythm_Homo sapiens_hsa047100.12052562
80* Glycosaminoglycan degradation_Homo sapiens_hsa005310.11413615
81Other glycan degradation_Homo sapiens_hsa005110.09873604
82Thyroid hormone synthesis_Homo sapiens_hsa049180.06706876
83Sphingolipid metabolism_Homo sapiens_hsa006000.05258574
84N-Glycan biosynthesis_Homo sapiens_hsa005100.04676567
85Ether lipid metabolism_Homo sapiens_hsa005650.01696770
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.00858421
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00037123
88Bladder cancer_Homo sapiens_hsa05219-0.1585036
89Insulin signaling pathway_Homo sapiens_hsa04910-0.1532164
90Pertussis_Homo sapiens_hsa05133-0.1403252
91Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1366714
92Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1342378
93Amoebiasis_Homo sapiens_hsa05146-0.1297089
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.1254233
95Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.1220336
96African trypanosomiasis_Homo sapiens_hsa05143-0.1100651
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1064559
98Hepatitis C_Homo sapiens_hsa05160-0.1061579
99Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1055510
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0977879
101Renin-angiotensin system_Homo sapiens_hsa04614-0.0952886
102ECM-receptor interaction_Homo sapiens_hsa04512-0.0894304
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0889325
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0826385
105* Lysosome_Homo sapiens_hsa04142-0.0773284
106Malaria_Homo sapiens_hsa05144-0.0649053
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0619496
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0610483
109Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0605966
110AMPK signaling pathway_Homo sapiens_hsa04152-0.0257930
111Glucagon signaling pathway_Homo sapiens_hsa04922-0.0058104

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