HYAL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)6.86700133
2blood vessel maturation (GO:0001955)6.80266323
3retina vasculature morphogenesis in camera-type eye (GO:0061299)5.86664191
4wound healing, spreading of epidermal cells (GO:0035313)5.68707389
5endothelial tube morphogenesis (GO:0061154)5.26833968
6morphogenesis of an endothelium (GO:0003159)5.26833968
7L-phenylalanine metabolic process (GO:0006558)5.19973267
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.19973267
9endothelial cell morphogenesis (GO:0001886)5.05513843
10L-phenylalanine catabolic process (GO:0006559)5.04453182
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.04453182
12glyoxylate metabolic process (GO:0046487)4.89516553
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.62635048
14negative regulation of fibrinolysis (GO:0051918)4.57778058
15aromatic amino acid family catabolic process (GO:0009074)4.42025848
16vascular endothelial growth factor signaling pathway (GO:0038084)4.39824847
17glycine metabolic process (GO:0006544)4.36087032
18basement membrane organization (GO:0071711)4.33700184
19cell adhesion mediated by integrin (GO:0033627)4.32566504
20lysine metabolic process (GO:0006553)4.22795267
21lysine catabolic process (GO:0006554)4.22795267
22negative regulation of blood vessel endothelial cell migration (GO:0043537)4.19418317
23alpha-linolenic acid metabolic process (GO:0036109)4.14577780
24cysteine metabolic process (GO:0006534)4.12968465
25wound healing, spreading of cells (GO:0044319)4.11772495
26sulfur amino acid catabolic process (GO:0000098)4.09310602
27serine family amino acid catabolic process (GO:0009071)4.04270143
28regulation of fibrinolysis (GO:0051917)4.02553165
29neuron projection extension involved in neuron projection guidance (GO:1902284)4.01403263
30axon extension involved in axon guidance (GO:0048846)4.01403263
31kynurenine metabolic process (GO:0070189)3.99292408
32tryptophan catabolic process (GO:0006569)3.87755824
33indole-containing compound catabolic process (GO:0042436)3.87755824
34indolalkylamine catabolic process (GO:0046218)3.87755824
35lymph vessel development (GO:0001945)3.85893775
36chondrocyte proliferation (GO:0035988)3.85593042
37positive regulation of endothelial cell differentiation (GO:0045603)3.85100655
38high-density lipoprotein particle remodeling (GO:0034375)3.80586853
39peptidyl-glutamic acid carboxylation (GO:0017187)3.79990536
40protein carboxylation (GO:0018214)3.79990536
41bile acid biosynthetic process (GO:0006699)3.79761159
42regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.78307673
43regulation of protein activation cascade (GO:2000257)3.76128650
44negative regulation of chondrocyte differentiation (GO:0032331)3.74086048
45serine family amino acid metabolic process (GO:0009069)3.72470408
46serine family amino acid biosynthetic process (GO:0009070)3.72229680
47vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.72021707
48urea cycle (GO:0000050)3.69509447
49urea metabolic process (GO:0019627)3.69509447
50negative regulation of endothelial cell migration (GO:0010596)3.69284302
51homocysteine metabolic process (GO:0050667)3.68709914
52tryptophan metabolic process (GO:0006568)3.66829135
53cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.65234496
54fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.62603129
55semaphorin-plexin signaling pathway (GO:0071526)3.61777834
56protein maturation by protein folding (GO:0022417)3.60690563
57amino-acid betaine metabolic process (GO:0006577)3.59248607
58Golgi transport vesicle coating (GO:0048200)3.57964102
59COPI coating of Golgi vesicle (GO:0048205)3.57964102
60complement activation, alternative pathway (GO:0006957)3.55058013
61regulation of complement activation (GO:0030449)3.54081864
62endothelial cell differentiation (GO:0045446)3.52815245
63aldehyde catabolic process (GO:0046185)3.51238014
64angiogenesis involved in wound healing (GO:0060055)3.51027245
65negative regulation of sterol transport (GO:0032372)3.50301707
66negative regulation of cholesterol transport (GO:0032375)3.50301707
67positive regulation of triglyceride lipase activity (GO:0061365)3.50187876
68positive regulation of lipoprotein lipase activity (GO:0051006)3.50187876
69regulation of triglyceride catabolic process (GO:0010896)3.45258445
70triglyceride homeostasis (GO:0070328)3.45184285
71acylglycerol homeostasis (GO:0055090)3.45184285
72endodermal cell differentiation (GO:0035987)3.42436837
73alpha-amino acid catabolic process (GO:1901606)3.40703703
74reverse cholesterol transport (GO:0043691)3.40312221
75arginine metabolic process (GO:0006525)3.38678577
76nitrogen cycle metabolic process (GO:0071941)3.37045650
77negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.35466034
78regulation of cholesterol esterification (GO:0010872)3.35148132
79regulation of endothelial cell differentiation (GO:0045601)3.31576872
80substrate-dependent cell migration (GO:0006929)3.30697755
81positive regulation of receptor recycling (GO:0001921)3.30607556
82negative regulation of focal adhesion assembly (GO:0051895)3.27311831
83negative regulation of cell junction assembly (GO:1901889)3.27311831
84negative regulation of adherens junction organization (GO:1903392)3.27311831
85bile acid metabolic process (GO:0008206)3.24721826
86aromatic amino acid family metabolic process (GO:0009072)3.23871234
87blood vessel endothelial cell migration (GO:0043534)3.23104077
88ganglion development (GO:0061548)3.22137408
89regulation of cholesterol homeostasis (GO:2000188)3.21677502
90paraxial mesoderm development (GO:0048339)3.21615262
91plasma lipoprotein particle clearance (GO:0034381)3.21017715
92protein-lipid complex remodeling (GO:0034368)3.20795735
93macromolecular complex remodeling (GO:0034367)3.20795735
94plasma lipoprotein particle remodeling (GO:0034369)3.20795735
95cell-substrate junction assembly (GO:0007044)3.20397662
96regulation of blood vessel endothelial cell migration (GO:0043535)3.20299282
97bile acid and bile salt transport (GO:0015721)3.20169440
98artery development (GO:0060840)3.20019855
99ethanol oxidation (GO:0006069)3.19757549
100imidazole-containing compound metabolic process (GO:0052803)3.15947190
101cellular amino acid catabolic process (GO:0009063)3.14037398
102endothelial cell proliferation (GO:0001935)3.12180849
103sprouting angiogenesis (GO:0002040)3.11278018
104heme transport (GO:0015886)3.10883094
105heart trabecula formation (GO:0060347)3.09637189
106drug catabolic process (GO:0042737)3.09002418
107surfactant homeostasis (GO:0043129)3.06032824
108phospholipid efflux (GO:0033700)3.05401412
109cell migration involved in sprouting angiogenesis (GO:0002042)3.04995588
110protein retention in ER lumen (GO:0006621)3.02581535
111hemidesmosome assembly (GO:0031581)3.01321385
112cellular modified amino acid catabolic process (GO:0042219)3.00003750
113apoptotic cell clearance (GO:0043277)2.99948202
114renal filtration (GO:0097205)2.99394333
115tyrosine metabolic process (GO:0006570)2.97028068
116cellular ketone body metabolic process (GO:0046950)2.96596332
117fibrinolysis (GO:0042730)2.96568835
118cell migration involved in heart development (GO:0060973)2.96530797
119urate metabolic process (GO:0046415)2.96328626
120positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.92665133
121maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.92572088
122aspartate family amino acid catabolic process (GO:0009068)2.92390229
123dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.92375020
124negative regulation of cartilage development (GO:0061037)2.91486132
125drug metabolic process (GO:0017144)2.90791208
126embryonic heart tube development (GO:0035050)2.90737421
127regulation of endothelial cell migration (GO:0010594)2.90308973
128vasculogenesis (GO:0001570)2.89592269
129adherens junction assembly (GO:0034333)2.88005589
130protein localization to endosome (GO:0036010)2.87785456
131negative regulation of epithelial cell migration (GO:0010633)2.87670478
132cholesterol homeostasis (GO:0042632)2.86539611
133folic acid metabolic process (GO:0046655)2.86293353
134glomerular filtration (GO:0003094)2.85647337
135plasma lipoprotein particle assembly (GO:0034377)2.84502424
136carnitine metabolic process (GO:0009437)2.83991118
137midgut development (GO:0007494)2.83698639
138positive regulation of fatty acid beta-oxidation (GO:0032000)2.83336997
139substrate adhesion-dependent cell spreading (GO:0034446)2.82871501
140branching involved in salivary gland morphogenesis (GO:0060445)2.82754413
141acetyl-CoA metabolic process (GO:0006084)2.81805919
142regulation of glomerular filtration (GO:0003093)2.81174927
143cellular glucuronidation (GO:0052695)2.80962281
144sterol homeostasis (GO:0055092)2.80919446
145regulation of cardioblast differentiation (GO:0051890)2.80548239
1462-oxoglutarate metabolic process (GO:0006103)2.80170704
147positive regulation of endothelial cell migration (GO:0010595)2.79963006
148L-serine metabolic process (GO:0006563)2.78768126
149negative regulation of cell fate specification (GO:0009996)2.78251101
150barbed-end actin filament capping (GO:0051016)2.77496710
151one-carbon metabolic process (GO:0006730)2.76354014
152arginine catabolic process (GO:0006527)2.75911259
153Notch signaling involved in heart development (GO:0061314)2.75253241
154folic acid-containing compound biosynthetic process (GO:0009396)2.74904514
155lipoprotein metabolic process (GO:0042157)2.74319263
156organic acid catabolic process (GO:0016054)2.73773533
157carboxylic acid catabolic process (GO:0046395)2.73773533
158tetrahydrofolate metabolic process (GO:0046653)2.73063526
159fatty acid beta-oxidation (GO:0006635)2.72008062
160epoxygenase P450 pathway (GO:0019373)2.71134854
161patterning of blood vessels (GO:0001569)2.70435701
162positive regulation of triglyceride metabolic process (GO:0090208)2.70401375
163response to nitrosative stress (GO:0051409)2.70280352
164regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.69318055
165venous blood vessel morphogenesis (GO:0048845)2.69135819
166regulation of plasminogen activation (GO:0010755)2.69007082
167embryonic foregut morphogenesis (GO:0048617)2.68776467
168gap junction assembly (GO:0016264)2.67972890
169atrioventricular valve morphogenesis (GO:0003181)2.67101990
170negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.66898568
171benzene-containing compound metabolic process (GO:0042537)2.66796655
172glomerular visceral epithelial cell development (GO:0072015)2.66558444
173exogenous drug catabolic process (GO:0042738)2.65107014
174angiogenesis (GO:0001525)2.64638239
175flavonoid metabolic process (GO:0009812)2.64464801
176valine metabolic process (GO:0006573)2.64324278
177negative regulation of anoikis (GO:2000811)2.64068090
1784-hydroxyproline metabolic process (GO:0019471)2.64042664
179glutamate metabolic process (GO:0006536)2.63855622
180lymphangiogenesis (GO:0001946)2.63724111
181positive regulation of cartilage development (GO:0061036)2.62413928
182endothelial cell chemotaxis (GO:0035767)2.62294284
183positive regulation of blood vessel endothelial cell migration (GO:0043536)2.57621961
184epithelial cell-cell adhesion (GO:0090136)2.56607931
185regulation of chondrocyte differentiation (GO:0032330)2.55979565
186glomerular basement membrane development (GO:0032836)2.54652631
187positive regulation of chondrocyte differentiation (GO:0032332)2.53753668
188positive regulation of endothelial cell apoptotic process (GO:2000353)2.52599996
189G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.52090051
190positive regulation of epithelial cell migration (GO:0010634)2.49465143
191blood vessel remodeling (GO:0001974)2.49041479
192regulation of epithelial cell migration (GO:0010632)2.48418816
193endothelial cell migration (GO:0043542)2.48404197
194regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.47155693
195facial nerve structural organization (GO:0021612)2.47049021
196cytoskeletal anchoring at plasma membrane (GO:0007016)2.47000244
197planar cell polarity pathway involved in neural tube closure (GO:0090179)2.46579733

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.57707278
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.37009386
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.35992895
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.04501305
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.48692182
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.25108773
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.22467145
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.13315047
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.08812922
10* MYC_18555785_ChIP-Seq_MESCs_Mouse2.91926132
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.91293355
12E2F7_22180533_ChIP-Seq_HELA_Human2.87629568
13GATA2_21666600_ChIP-Seq_HMVEC_Human2.56204479
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.51660789
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.43245748
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.26221219
17CLOCK_20551151_ChIP-Seq_293T_Human2.23250462
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.07316771
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97635616
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92304796
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91716263
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.90224141
23* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.89028678
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.88494745
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88071204
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.84655009
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79970519
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78600665
29AR_21909140_ChIP-Seq_LNCAP_Human1.78493824
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75548583
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75499728
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.74435872
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73571244
34XRN2_22483619_ChIP-Seq_HELA_Human1.72531867
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71256662
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.70485796
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67768661
38* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.66635903
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.63394295
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63114005
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.60849673
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59723857
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59365720
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57448557
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56439379
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52940659
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51905473
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48429875
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.48271832
50* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45490568
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.45125057
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44795260
53KDM2B_26808549_Chip-Seq_K562_Human1.43103106
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.42946326
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41738121
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41694555
57* TBX20_22328084_ChIP-Seq_HEART_Mouse1.40372808
58* TBX20_22080862_ChIP-Seq_HEART_Mouse1.40372808
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.39429051
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37487728
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37082722
62* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36996903
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36786797
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36722691
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36171640
66* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.33912955
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33229509
68* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.32029465
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.31810991
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30544961
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30174604
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30174604
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30174604
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29752567
75UBF1/2_26484160_Chip-Seq_HMECs_Human1.29663058
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29090283
77TP53_22127205_ChIP-Seq_IMR90_Human1.28202052
78ZNF263_19887448_ChIP-Seq_K562_Human1.27265613
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26803622
80* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24965741
81* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20467765
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20081666
83DCP1A_22483619_ChIP-Seq_HELA_Human1.18115963
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17340896
85SMC3_22415368_ChIP-Seq_MEFs_Mouse1.16443423
86TET1_21490601_ChIP-Seq_MESCs_Mouse1.16193676
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14642476
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14441568
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14356407
90NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13590844
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12289363
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12285574
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11212554
94ESR1_21235772_ChIP-Seq_MCF-7_Human1.10619740
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09405589
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09279924
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08014298
98EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07939449
99* ELK3_25401928_ChIP-Seq_HUVEC_Human1.07453062
100E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06974927
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06822575
102* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06096496
103SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04479912
104ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04140227
105* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03525972
106HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02823223
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02559756
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02559756
109* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01657709
110* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.01631087
111* GABP_19822575_ChIP-Seq_HepG2_Human1.01096542
112TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.00741302
113ATF3_27146783_Chip-Seq_COLON_Human1.00261699
114* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98767775
115* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98424969
116MYC_22102868_ChIP-Seq_BL_Human0.96945300
117RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96906967
118SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96738927
119* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96528700
120CTCF_27219007_Chip-Seq_Bcells_Human0.95829119
121MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94660763
122CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94249236
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94050579
124MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93200840
125SRF_21415370_ChIP-Seq_HL-1_Mouse0.92567638
126* LXR_22292898_ChIP-Seq_THP-1_Human0.92372174
127TTF2_22483619_ChIP-Seq_HELA_Human0.90736305
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90144478
129SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89729937
130RACK7_27058665_Chip-Seq_MCF-7_Human0.88875658
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88000221
132KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87334863
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86963878
134SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86741055
135PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86294535
136STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86245695
137* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85214983
138NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84338847
139DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83847857
140CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83652247
141PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82900912
142TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82618774
143E2F1_21310950_ChIP-Seq_MCF-7_Human0.82604151
144POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.82407305
145TET1_21451524_ChIP-Seq_MESCs_Mouse0.82240617
146YY1_21170310_ChIP-Seq_MESCs_Mouse0.82010440
147KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81778399
148* SOX17_20123909_ChIP-Seq_XEN_Mouse0.81110841
149THAP11_20581084_ChIP-Seq_MESCs_Mouse0.80814031
150SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.80116082
151* FOXP3_21729870_ChIP-Seq_TREG_Human0.80000787

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.16875586
2MP0005360_urolithiasis5.53921792
3MP0005085_abnormal_gallbladder_physiolo3.98981092
4MP0005365_abnormal_bile_salt3.96825376
5MP0003806_abnormal_nucleotide_metabolis3.79450748
6MP0008875_abnormal_xenobiotic_pharmacok3.23928428
7MP0010368_abnormal_lymphatic_system2.52891308
8MP0003705_abnormal_hypodermis_morpholog2.45202639
9MP0000767_abnormal_smooth_muscle2.43297811
10MP0010329_abnormal_lipoprotein_level2.36320263
11MP0003252_abnormal_bile_duct2.34722923
12MP0005623_abnormal_meninges_morphology2.29169097
13MP0009840_abnormal_foam_cell2.24180813
14MP0005257_abnormal_intraocular_pressure2.19877177
15MP0002877_abnormal_melanocyte_morpholog2.18076388
16MP0005332_abnormal_amino_acid2.07086158
17MP0003828_pulmonary_edema2.03616615
18MP0003191_abnormal_cellular_cholesterol1.98651202
19MP0009053_abnormal_anal_canal1.95144224
20MP0005083_abnormal_biliary_tract1.95065728
21MP0006138_congestive_heart_failure1.75556628
22MP0000751_myopathy1.75176939
23MP0001666_abnormal_nutrient_absorption1.73812935
24MP0005595_abnormal_vascular_smooth1.69987346
25MP0004019_abnormal_vitamin_homeostasis1.69864116
26MP0005409_darkened_coat_color1.64605970
27MP0004782_abnormal_surfactant_physiolog1.59478017
28MP0002295_abnormal_pulmonary_circulatio1.58080132
29MP0004272_abnormal_basement_membrane1.55748515
30MP0003091_abnormal_cell_migration1.53567889
31MP0004233_abnormal_muscle_weight1.51104026
32MP0002138_abnormal_hepatobiliary_system1.49035624
33MP0004858_abnormal_nervous_system1.47492802
34MP0002249_abnormal_larynx_morphology1.45776823
35* MP0000609_abnormal_liver_physiology1.45646024
36MP0001614_abnormal_blood_vessel1.44567850
37MP0006054_spinal_hemorrhage1.42248096
38MP0008260_abnormal_autophagy1.41498581
39MP0003186_abnormal_redox_activity1.40943045
40MP0001879_abnormal_lymphatic_vessel1.39203522
41MP0000049_abnormal_middle_ear1.37256170
42MP0000465_gastrointestinal_hemorrhage1.36114760
43* MP0005319_abnormal_enzyme/_coenzyme1.36039200
44MP0005058_abnormal_lysosome_morphology1.34741167
45* MP0010030_abnormal_orbit_morphology1.34667699
46MP0000537_abnormal_urethra_morphology1.32431523
47MP0002925_abnormal_cardiovascular_devel1.31608647
48MP0003195_calcinosis1.27981594
49MP0009643_abnormal_urine_homeostasis1.25082454
50MP0002127_abnormal_cardiovascular_syste1.20700047
51MP0004957_abnormal_blastocyst_morpholog1.19405554
52MP0002128_abnormal_blood_circulation1.18509263
53MP0008007_abnormal_cellular_replicative1.17805335
54MP0000598_abnormal_liver_morphology1.17297535
55MP0004133_heterotaxia1.16804379
56MP0004084_abnormal_cardiac_muscle1.16642453
57MP0002118_abnormal_lipid_homeostasis1.14425067
58MP0005367_renal/urinary_system_phenotyp1.11731579
59MP0000516_abnormal_urinary_system1.11731579
60MP0005330_cardiomyopathy1.10241691
61MP0000762_abnormal_tongue_morphology1.09491069
62MP0001958_emphysema1.07852740
63MP0009697_abnormal_copulation1.07490325
64MP0008438_abnormal_cutaneous_collagen1.05892403
65MP0005165_increased_susceptibility_to1.05072330
66MP0003890_abnormal_embryonic-extraembry1.04973863
67MP0005508_abnormal_skeleton_morphology1.04408258
68MP0002933_joint_inflammation1.03817064
69MP0000467_abnormal_esophagus_morphology1.02957320
70MP0003279_aneurysm1.02248406
71MP0010234_abnormal_vibrissa_follicle1.01456478
72MP0010352_gastrointestinal_tract_polyps1.01404837
73MP0003011_delayed_dark_adaptation0.99774795
74MP0003693_abnormal_embryo_hatching0.99553774
75MP0010630_abnormal_cardiac_muscle0.98970756
76MP0001764_abnormal_homeostasis0.98372300
77MP0006036_abnormal_mitochondrial_physio0.98081745
78MP0003935_abnormal_craniofacial_develop0.97772689
79MP0009384_cardiac_valve_regurgitation0.97175937
80MP0002092_abnormal_eye_morphology0.96887912
81MP0009672_abnormal_birth_weight0.96228186
82MP0000003_abnormal_adipose_tissue0.95149536
83MP0005197_abnormal_uvea_morphology0.94481395
84MP0009780_abnormal_chondrocyte_physiolo0.94289411
85MP0000249_abnormal_blood_vessel0.93193424
86MP0002896_abnormal_bone_mineralization0.93002395
87MP0005023_abnormal_wound_healing0.92843823
88MP0002282_abnormal_trachea_morphology0.91687268
89MP0003111_abnormal_nucleus_morphology0.91578017
90MP0001730_embryonic_growth_arrest0.91369220
91MP0003566_abnormal_cell_adhesion0.91230346
92MP0000678_abnormal_parathyroid_gland0.90170116
93MP0000343_altered_response_to0.89829236
94MP0004197_abnormal_fetal_growth/weight/0.88583084
95MP0002088_abnormal_embryonic_growth/wei0.87071570
96MP0000266_abnormal_heart_morphology0.86434160
97MP0001915_intracranial_hemorrhage0.86395129
98MP0003984_embryonic_growth_retardation0.86229205
99MP0000749_muscle_degeneration0.85901612
100MP0003950_abnormal_plasma_membrane0.85083976
101MP0005380_embryogenesis_phenotype0.84398470
102MP0001672_abnormal_embryogenesis/_devel0.84398470
103MP0004043_abnormal_pH_regulation0.84299897
104MP0003119_abnormal_digestive_system0.83902192
105MP0005501_abnormal_skin_physiology0.83498314
106MP0000733_abnormal_muscle_development0.83247887
107MP0006035_abnormal_mitochondrial_morpho0.82752444
108MP0005248_abnormal_Harderian_gland0.80320677
109MP0003115_abnormal_respiratory_system0.79874822
110MP0002060_abnormal_skin_morphology0.79602101
111MP0002089_abnormal_postnatal_growth/wei0.79473562
112MP0001299_abnormal_eye_distance/0.79221478
113MP0001756_abnormal_urination0.78397810
114MP0002972_abnormal_cardiac_muscle0.77439533
115MP0003567_abnormal_fetal_cardiomyocyte0.76459596
116MP0000566_synostosis0.75855876
117MP0000428_abnormal_craniofacial_morphol0.74932072
118MP0002111_abnormal_tail_morphology0.74729715
119MP0005670_abnormal_white_adipose0.74706961
120MP0003942_abnormal_urinary_system0.74313858
121MP0002086_abnormal_extraembryonic_tissu0.74048790
122MP0003077_abnormal_cell_cycle0.74025125
123MP0002254_reproductive_system_inflammat0.72954179
124MP0005503_abnormal_tendon_morphology0.72903761
125MP0003123_paternal_imprinting0.72635420
126MP0005584_abnormal_enzyme/coenzyme_acti0.72481724
127MP0005167_abnormal_blood-brain_barrier0.72049812
128MP0005266_abnormal_metabolism0.71932279
129MP0004087_abnormal_muscle_fiber0.71494012
130MP0000750_abnormal_muscle_regeneration0.71441988
131MP0001544_abnormal_cardiovascular_syste0.71209393
132MP0005385_cardiovascular_system_phenoty0.71209393
133MP0003718_maternal_effect0.70999561
134* MP0002932_abnormal_joint_morphology0.70849192
135MP0009763_increased_sensitivity_to0.70605931
136MP0001697_abnormal_embryo_size0.70369916
137MP0002098_abnormal_vibrissa_morphology0.70340283
138MP0002084_abnormal_developmental_patter0.70319173
139MP0005451_abnormal_body_composition0.69942833
140MP0003385_abnormal_body_wall0.69606735
141MP0002796_impaired_skin_barrier0.68552028
142MP0001293_anophthalmia0.67503929
143MP0008932_abnormal_embryonic_tissue0.66632342
144MP0002108_abnormal_muscle_morphology0.64855299
145MP0005408_hypopigmentation0.64735844
146MP0005376_homeostasis/metabolism_phenot0.64314010
147MP0000462_abnormal_digestive_system0.64097124
148MP0005084_abnormal_gallbladder_morpholo0.63589697
149MP0005275_abnormal_skin_tensile0.63559721
150MP0003941_abnormal_skin_development0.63536738
151MP0002697_abnormal_eye_size0.62874250
152MP0002085_abnormal_embryonic_tissue0.62572946
153MP0005193_abnormal_anterior_eye0.62535985
154MP0001661_extended_life_span0.62365793
155MP0001849_ear_inflammation0.62167680
156MP0002233_abnormal_nose_morphology0.62060866
157MP0004036_abnormal_muscle_relaxation0.61418794
158MP0003315_abnormal_perineum_morphology0.61357269
159MP0004264_abnormal_extraembryonic_tissu0.60916642
160MP0008058_abnormal_DNA_repair0.60608864
161MP0000013_abnormal_adipose_tissue0.59842234
162MP0002080_prenatal_lethality0.59785541

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.55004407
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.13298331
3Premature rupture of membranes (HP:0001788)5.01721853
4Hypobetalipoproteinemia (HP:0003563)4.88089407
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.86828338
6Intrahepatic cholestasis (HP:0001406)4.73551626
7Xanthomatosis (HP:0000991)4.41973168
8Prolonged partial thromboplastin time (HP:0003645)3.98173617
9Cervical subluxation (HP:0003308)3.78691932
10Hypolipoproteinemia (HP:0010981)3.64162819
11Cerebral aneurysm (HP:0004944)3.63811315
12Hyperglycinuria (HP:0003108)3.61036626
13Hyperammonemia (HP:0001987)3.58263106
14Spinal rigidity (HP:0003306)3.58035851
15Wrist flexion contracture (HP:0001239)3.56979918
16Abnormality of glutamine family amino acid metabolism (HP:0010902)3.50750237
17Vascular tortuosity (HP:0004948)3.49455028
18Arterial tortuosity (HP:0005116)3.49076146
19Abnormality of pyrimidine metabolism (HP:0004353)3.47918116
20Complement deficiency (HP:0004431)3.33541987
21Hyperlipoproteinemia (HP:0010980)3.26910589
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.26089823
23Hypoglycemic coma (HP:0001325)3.25890920
24Skull defect (HP:0001362)3.24244533
25Hypercholesterolemia (HP:0003124)3.21148794
26Abnormality of serine family amino acid metabolism (HP:0010894)3.19648934
27Abnormality of glycine metabolism (HP:0010895)3.19648934
28Hyperglycinemia (HP:0002154)3.17352388
29Ketosis (HP:0001946)3.16683217
30Hematochezia (HP:0002573)3.13196186
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.12635259
32Shallow orbits (HP:0000586)3.12256017
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.08282602
34Hypoalphalipoproteinemia (HP:0003233)3.07123539
35Delayed CNS myelination (HP:0002188)3.00989598
36Abnormality of the intrinsic pathway (HP:0010989)2.99253117
37Vertebral compression fractures (HP:0002953)2.84255145
38Esophageal varix (HP:0002040)2.82975748
39Abnormality of the common coagulation pathway (HP:0010990)2.81957642
40Abnormality of methionine metabolism (HP:0010901)2.79564766
41Abnormality of fatty-acid metabolism (HP:0004359)2.78856863
42Spastic diplegia (HP:0001264)2.76957612
43Short nail (HP:0001799)2.75062183
44Epidermoid cyst (HP:0200040)2.74941354
45Increased connective tissue (HP:0009025)2.72607861
46Aortic aneurysm (HP:0004942)2.70896095
47Aortic dissection (HP:0002647)2.68520924
48Late onset (HP:0003584)2.68163167
49Spontaneous hematomas (HP:0007420)2.66799308
50Abnormality of nucleobase metabolism (HP:0010932)2.66070033
51Abnormality of complement system (HP:0005339)2.63194152
52Bilateral microphthalmos (HP:0007633)2.58335402
53Difficulty climbing stairs (HP:0003551)2.57634636
54Joint hemorrhage (HP:0005261)2.57399654
55Wormian bones (HP:0002645)2.55403650
56Nonimmune hydrops fetalis (HP:0001790)2.53173977
57Fat malabsorption (HP:0002630)2.52502941
58Hepatocellular carcinoma (HP:0001402)2.49979596
59Hypochromic microcytic anemia (HP:0004840)2.49809688
60Dicarboxylic aciduria (HP:0003215)2.49332429
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49332429
62Distal lower limb muscle weakness (HP:0009053)2.48453900
63Ketoacidosis (HP:0001993)2.46958732
64Abnormal cartilage morphology (HP:0002763)2.43033466
65Hyperbilirubinemia (HP:0002904)2.41220065
66Blue sclerae (HP:0000592)2.40888762
67Multiple enchondromatosis (HP:0005701)2.40210623
68Abnormality of the aortic arch (HP:0012303)2.38775574
69Disproportionate tall stature (HP:0001519)2.36659885
70Abnormality of the acetabulum (HP:0003170)2.35810254
71Atrophic scars (HP:0001075)2.33942711
72Malnutrition (HP:0004395)2.33569802
73Hemorrhage of the eye (HP:0011885)2.32947717
74Upper limb amyotrophy (HP:0009129)2.31324852
75Distal upper limb amyotrophy (HP:0007149)2.31324852
76Cerebral hemorrhage (HP:0001342)2.30660987
77Conjunctival telangiectasia (HP:0000524)2.29676897
78Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.29418619
79Lethargy (HP:0001254)2.28070025
80Proximal tubulopathy (HP:0000114)2.27853702
81Polycythemia (HP:0001901)2.27495691
82Abnormality of purine metabolism (HP:0004352)2.25145991
83Abnormal vertebral ossification (HP:0100569)2.24467820
84Gout (HP:0001997)2.24235970
85Flat acetabular roof (HP:0003180)2.22951081
86Visceral angiomatosis (HP:0100761)2.21838581
87Hemangiomatosis (HP:0007461)2.21533682
88Vertebral clefting (HP:0008428)2.20853887
89Nausea (HP:0002018)2.20416514
90Protrusio acetabuli (HP:0003179)2.19640581
91Bladder diverticulum (HP:0000015)2.18969294
92Mesangial abnormality (HP:0001966)2.18017776
93Lymphangioma (HP:0100764)2.17317685
94Mitral valve prolapse (HP:0001634)2.16622130
95Cerebral edema (HP:0002181)2.16345381
96Abnormality of dentin (HP:0010299)2.15449810
97Opisthotonus (HP:0002179)2.14700046
98Trismus (HP:0000211)2.14474156
99Abnormality of serum amino acid levels (HP:0003112)2.12920857
100Broad metatarsal (HP:0001783)2.11585986
101Ankle contracture (HP:0006466)2.09415010
102Ulnar bowing (HP:0003031)2.09382584
103Coxa vara (HP:0002812)2.08994917
104Broad face (HP:0000283)2.03483475
105Metabolic acidosis (HP:0001942)2.01955460
106Ankyloglossia (HP:0010296)2.00804076
107Increased variability in muscle fiber diameter (HP:0003557)1.99724185
108Vascular calcification (HP:0004934)1.99087947
109Back pain (HP:0003418)1.98853541
110Distal lower limb amyotrophy (HP:0008944)1.98346084
111Aortic valve stenosis (HP:0001650)1.97164878
112Soft skin (HP:0000977)1.96762166
113Joint stiffness (HP:0001387)1.96118707
114Vomiting (HP:0002013)1.95042273
115Joint laxity (HP:0001388)1.93875736
116Right ventricular cardiomyopathy (HP:0011663)1.93607417
117Neonatal onset (HP:0003623)1.93466522
118Ectopia lentis (HP:0001083)1.92233707
119Portal hypertension (HP:0001409)1.92211676
120Prominent metopic ridge (HP:0005487)1.92199693
121Skin nodule (HP:0200036)1.92173352
122Aneurysm (HP:0002617)1.91623276
123Venous insufficiency (HP:0005293)1.91590553
124Hydroureter (HP:0000072)1.91354907
125Cardiovascular calcification (HP:0011915)1.89179760
126Venous abnormality (HP:0002624)1.88656517
127Adactyly (HP:0009776)1.88316179
128Natal tooth (HP:0000695)1.87885241
129Hand muscle atrophy (HP:0009130)1.87217146
130Neonatal death (HP:0003811)1.86980503
131Abnormality of the metopic suture (HP:0005556)1.85848010
132Enlarged kidneys (HP:0000105)1.85661487
133Menorrhagia (HP:0000132)1.85007022
134Increased serum pyruvate (HP:0003542)1.82945032
135Abnormality of glycolysis (HP:0004366)1.82945032
136Stroke (HP:0001297)1.82550919
137Mildly elevated creatine phosphokinase (HP:0008180)1.79578529
138Premature skin wrinkling (HP:0100678)1.78829177
139Reduced subcutaneous adipose tissue (HP:0003758)1.78750364
140Hepatic necrosis (HP:0002605)1.78177553
141Hepatoblastoma (HP:0002884)1.78129508
142Abnormality of the nasal mucosa (HP:0000433)1.77744764
143Abnormality of carpal bone ossification (HP:0006257)1.77637151
144Rhabdomyolysis (HP:0003201)1.77535020
145Advanced eruption of teeth (HP:0006288)1.77424481
146Abnormality of the hepatic vasculature (HP:0006707)1.77304454
147Tetraparesis (HP:0002273)1.77053035
148Reticulocytosis (HP:0001923)1.76857894
149Abnormality of oral frenula (HP:0000190)1.75619361
150Generalized aminoaciduria (HP:0002909)1.75597748
151Oral leukoplakia (HP:0002745)1.75576969
152Abnormality of skeletal muscle fiber size (HP:0012084)1.74620472
153Fragile skin (HP:0001030)1.74334964
154Absent hand (HP:0004050)1.74311688
155Overgrowth (HP:0001548)1.73593025
156Steatorrhea (HP:0002570)1.73312547
157Limb-girdle muscle atrophy (HP:0003797)1.72490040
158Bronchomalacia (HP:0002780)1.72480667
159Myocardial infarction (HP:0001658)1.71894235
160Hypertriglyceridemia (HP:0002155)1.71509598
161Protruding ear (HP:0000411)1.70615566
162Hydroxyprolinuria (HP:0003080)1.70212903
163Abnormality of proline metabolism (HP:0010907)1.70212903
164Dilatation of the ascending aorta (HP:0005111)1.68948750
165Systemic lupus erythematosus (HP:0002725)1.68762835
166Mitral stenosis (HP:0001718)1.68216365
167Abnormality of the vasculature of the conjunctiva (HP:0008054)1.67327507
168Centrally nucleated skeletal muscle fibers (HP:0003687)1.66577730
169Lumbar hyperlordosis (HP:0002938)1.66140784
170Mitral regurgitation (HP:0001653)1.65921581
171Congenital glaucoma (HP:0001087)1.65769686
172Macrocytic anemia (HP:0001972)1.64842953
173Abnormal ossification of hand bones (HP:0005921)1.64533120
174Cholelithiasis (HP:0001081)1.63678150
175Increased purine levels (HP:0004368)1.62794801
176Hyperuricemia (HP:0002149)1.62794801
177Conjugated hyperbilirubinemia (HP:0002908)1.61484006
178Selective tooth agenesis (HP:0001592)1.60295156
179Arachnodactyly (HP:0001166)1.59605050
180Ragged-red muscle fibers (HP:0003200)1.59404287
181Abnormality of urine glucose concentration (HP:0011016)1.59072684
182Glycosuria (HP:0003076)1.59072684
183Abnormality of iron homeostasis (HP:0011031)1.58734166
184Hip contracture (HP:0003273)1.58268205
185Abnormal gallbladder morphology (HP:0012437)1.57444194
186Myoglobinuria (HP:0002913)1.57327336
187Subcapsular cataract (HP:0000523)1.57139441
188Myotonia (HP:0002486)1.56364363
189Hyperacusis (HP:0010780)1.55998727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.06188366
2BCKDK3.90603714
3TIE13.30055475
4TRIB33.25720029
5ERN12.74640819
6EPHB22.72830234
7BUB12.48670208
8PKN22.32863644
9PAK42.25699462
10TESK22.14342088
11NTRK12.12804828
12EPHA22.12133512
13TGFBR11.99197091
14NEK11.97461828
15SIK11.96854927
16MAP3K101.89244217
17PTK61.81730799
18FGFR41.76710006
19STK38L1.74158114
20SMG11.57488100
21PASK1.53477209
22TGFBR21.51675575
23LATS11.44292651
24TAOK21.41885409
25MAP3K111.38598273
26LATS21.34033799
27EPHB11.30837139
28WEE11.30731367
29TESK11.27460827
30NEK21.23795933
31WNK31.21095341
32RPS6KA41.18644301
33STK101.16549981
34PRKG21.15914560
35MAPK111.12550094
36TTN1.12318919
37ABL21.12317599
38FLT31.11815583
39MAP3K81.11104633
40EEF2K1.10314275
41LRRK21.09113963
42NME21.08673170
43EIF2AK11.06064939
44IRAK31.04142488
45MAP2K21.01602833
46ARAF0.99936344
47MAP3K30.99503786
48AURKA0.98826778
49LMTK20.97306425
50MAP2K30.97202165
51BRSK20.96174638
52TLK10.95970016
53MYLK0.95295292
54PTK2B0.94640305
55ERBB20.94312250
56PTK20.90578521
57AURKB0.89926352
58PRKD30.89851085
59CDK70.89486576
60ICK0.88614969
61TTK0.88280754
62CDK40.88231277
63FES0.87789353
64FGFR10.86822386
65PLK10.86074913
66PDGFRA0.84929525
67BRSK10.84205902
68ACVR1B0.84126927
69NEK90.83291968
70DYRK30.83203461
71ERBB40.82605513
72CDK60.80243988
73SRPK10.80020750
74MTOR0.79570029
75DYRK1B0.74145075
76RPS6KA20.72847053
77PLK40.71709212
78LIMK10.70798666
79RPS6KB20.70437278
80FER0.67137226
81PAK20.66140716
82MET0.64950031
83ROCK20.64534457
84ILK0.63932742
85STK40.63361212
86MST1R0.62557970
87MOS0.62394849
88DDR20.61139278
89RIPK10.58847287
90BMX0.58176292
91AKT20.57882334
92CDC70.57610964
93PBK0.55281123
94PDK20.54886054
95CDC42BPA0.54857359
96MAP3K60.54566289
97INSRR0.54495624
98DAPK30.53928801
99PAK10.50040100
100CSNK1A1L0.48617083
101CDK120.47813378
102PIK3CG0.47158550
103CDK80.47082941
104TSSK60.46281090
105CSNK1G30.45805378
106MKNK10.45684993
107DYRK20.45632249
108MAPKAPK30.45075366
109BRAF0.44686334
110CSNK1G10.44252182
111PRKCI0.42968241
112PRKD20.42405993
113PDGFRB0.41913695
114BCR0.41310609
115CSNK2A10.41224554
116MAP2K10.39797176
117DMPK0.39414011
118TYK20.38493042
119ATR0.38025982
120CHUK0.37443191
121KSR20.36645475
122CDK90.36572847
123PRKD10.36525882
124MELK0.36042050
125SRC0.35872821
126FRK0.35388918
127MARK20.34984714
128SCYL20.34834479
129ROCK10.34123644
130PLK30.33306424
131WNK40.32494274
132PIM20.32363872
133GSK3A0.31473233
134RPS6KC10.31085425
135RPS6KL10.31085425
136RPS6KA10.30605145
137PRKAA20.28537664
138TYRO30.27328940
139PAK60.25417718
140PDPK10.25246605
141DAPK10.23436339
142PRPF4B0.23120116
143MAP3K10.23066370
144EGFR0.21849092

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.43581048
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.27382211
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.95091723
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.72102565
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.58183207
6Arginine biosynthesis_Homo sapiens_hsa002202.50705291
7* Glycosaminoglycan degradation_Homo sapiens_hsa005312.49256002
8Fatty acid degradation_Homo sapiens_hsa000712.43991097
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.42563505
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.36348339
11Focal adhesion_Homo sapiens_hsa045102.29745487
12Tryptophan metabolism_Homo sapiens_hsa003802.27940292
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27795945
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.22968073
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.19499487
16Complement and coagulation cascades_Homo sapiens_hsa046102.16521609
17Nitrogen metabolism_Homo sapiens_hsa009102.14402249
18Adherens junction_Homo sapiens_hsa045202.07183412
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.98195613
20Propanoate metabolism_Homo sapiens_hsa006401.91512378
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.91037756
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.87808865
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.86744399
24Selenocompound metabolism_Homo sapiens_hsa004501.82173786
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.80786587
26Peroxisome_Homo sapiens_hsa041461.77029135
27Fatty acid metabolism_Homo sapiens_hsa012121.71737870
28Butanoate metabolism_Homo sapiens_hsa006501.68499068
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67442653
30One carbon pool by folate_Homo sapiens_hsa006701.66914582
31Biosynthesis of amino acids_Homo sapiens_hsa012301.66446584
32PPAR signaling pathway_Homo sapiens_hsa033201.65811965
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65120182
34Carbon metabolism_Homo sapiens_hsa012001.59710930
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56339589
36Chemical carcinogenesis_Homo sapiens_hsa052041.53634654
37Pyruvate metabolism_Homo sapiens_hsa006201.53480045
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.49747420
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.49230009
40Proteoglycans in cancer_Homo sapiens_hsa052051.48972263
41Dilated cardiomyopathy_Homo sapiens_hsa054141.48949975
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.47122655
43beta-Alanine metabolism_Homo sapiens_hsa004101.44388224
44Folate biosynthesis_Homo sapiens_hsa007901.44224319
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42892534
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.42069712
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.40655766
48Axon guidance_Homo sapiens_hsa043601.39732401
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.39062534
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37352108
51Other glycan degradation_Homo sapiens_hsa005111.37351768
52Proteasome_Homo sapiens_hsa030501.33467986
53Fat digestion and absorption_Homo sapiens_hsa049751.31987031
54Caffeine metabolism_Homo sapiens_hsa002321.30243515
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.29056894
56Retinol metabolism_Homo sapiens_hsa008301.28331080
57Sulfur relay system_Homo sapiens_hsa041221.27293148
58Tight junction_Homo sapiens_hsa045301.26983852
59N-Glycan biosynthesis_Homo sapiens_hsa005101.25818334
60Phenylalanine metabolism_Homo sapiens_hsa003601.25560262
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25464707
62Histidine metabolism_Homo sapiens_hsa003401.23841031
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21863649
64Amoebiasis_Homo sapiens_hsa051461.18544661
65Glutathione metabolism_Homo sapiens_hsa004801.18256736
66Bile secretion_Homo sapiens_hsa049761.16508501
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15079372
68PI3K-Akt signaling pathway_Homo sapiens_hsa041511.13576145
69Arginine and proline metabolism_Homo sapiens_hsa003301.12907696
70Tyrosine metabolism_Homo sapiens_hsa003501.12530088
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11445394
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10072750
73Staphylococcus aureus infection_Homo sapiens_hsa051501.07725358
74Fatty acid elongation_Homo sapiens_hsa000621.05925734
75Starch and sucrose metabolism_Homo sapiens_hsa005000.99336893
76Ribosome_Homo sapiens_hsa030100.99091185
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.98712955
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98080835
79Rap1 signaling pathway_Homo sapiens_hsa040150.97759256
80Lysine degradation_Homo sapiens_hsa003100.96613772
81Vibrio cholerae infection_Homo sapiens_hsa051100.95849914
82Protein digestion and absorption_Homo sapiens_hsa049740.94375676
83Pathways in cancer_Homo sapiens_hsa052000.92594761
84Hedgehog signaling pathway_Homo sapiens_hsa043400.91167040
85Pentose phosphate pathway_Homo sapiens_hsa000300.90525990
86Chronic myeloid leukemia_Homo sapiens_hsa052200.89803668
87MicroRNAs in cancer_Homo sapiens_hsa052060.89439959
88Vitamin digestion and absorption_Homo sapiens_hsa049770.89077419
89DNA replication_Homo sapiens_hsa030300.86820772
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85623295
91Shigellosis_Homo sapiens_hsa051310.82943472
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79073006
93HIF-1 signaling pathway_Homo sapiens_hsa040660.78963184
94Pyrimidine metabolism_Homo sapiens_hsa002400.77951275
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76712270
96Spliceosome_Homo sapiens_hsa030400.71864722
97Sulfur metabolism_Homo sapiens_hsa009200.71708184
98Mismatch repair_Homo sapiens_hsa034300.70449867
99Lysosome_Homo sapiens_hsa041420.70297881
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67883669
101Pancreatic cancer_Homo sapiens_hsa052120.66941018
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65900287
103ABC transporters_Homo sapiens_hsa020100.65666636
104Melanogenesis_Homo sapiens_hsa049160.64673768
105Vitamin B6 metabolism_Homo sapiens_hsa007500.62813668
106Wnt signaling pathway_Homo sapiens_hsa043100.62042922
107Gap junction_Homo sapiens_hsa045400.61458212
108Steroid biosynthesis_Homo sapiens_hsa001000.61420396
109RNA transport_Homo sapiens_hsa030130.58392108
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58004457
111VEGF signaling pathway_Homo sapiens_hsa043700.57721527
112Nucleotide excision repair_Homo sapiens_hsa034200.57274581
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56074032
114Pertussis_Homo sapiens_hsa051330.55781471
115Galactose metabolism_Homo sapiens_hsa000520.55585841
116RNA polymerase_Homo sapiens_hsa030200.55359440
117AMPK signaling pathway_Homo sapiens_hsa041520.54400183
118Base excision repair_Homo sapiens_hsa034100.54160167
119Endocytosis_Homo sapiens_hsa041440.53432376
120Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53211401
121* Metabolic pathways_Homo sapiens_hsa011000.52238404
122Fructose and mannose metabolism_Homo sapiens_hsa000510.49455306
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.49386117
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48090100
125Basal cell carcinoma_Homo sapiens_hsa052170.46654834
126Insulin signaling pathway_Homo sapiens_hsa049100.45625853
127Colorectal cancer_Homo sapiens_hsa052100.44828520
128Salmonella infection_Homo sapiens_hsa051320.44749979
129Renal cell carcinoma_Homo sapiens_hsa052110.44032696
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39745749
131Bladder cancer_Homo sapiens_hsa052190.39392958
132Sphingolipid metabolism_Homo sapiens_hsa006000.38673733
133Cell cycle_Homo sapiens_hsa041100.37612387
134Homologous recombination_Homo sapiens_hsa034400.37546746
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33715420
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32490258
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32208875
138Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32016539
139Glycerolipid metabolism_Homo sapiens_hsa005610.31011027
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30072296
141TGF-beta signaling pathway_Homo sapiens_hsa043500.29225970
142Systemic lupus erythematosus_Homo sapiens_hsa053220.28329160
143p53 signaling pathway_Homo sapiens_hsa041150.24760341
144Insulin resistance_Homo sapiens_hsa049310.23409714
145Parkinsons disease_Homo sapiens_hsa050120.23362786
146Hippo signaling pathway_Homo sapiens_hsa043900.23209389
147Renin-angiotensin system_Homo sapiens_hsa046140.23167839
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.18790564
149Prion diseases_Homo sapiens_hsa050200.17384204
150Thyroid cancer_Homo sapiens_hsa052160.16973489
151Small cell lung cancer_Homo sapiens_hsa052220.15420766
152Notch signaling pathway_Homo sapiens_hsa043300.15213898
153Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12500842

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