HYAL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.68816472
2superoxide anion generation (GO:0042554)4.46456319
3pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.32949886
4protoporphyrinogen IX metabolic process (GO:0046501)4.20762231
5neutrophil activation involved in immune response (GO:0002283)4.18352656
6deoxyribonucleotide catabolic process (GO:0009264)3.94412637
7deoxyribose phosphate catabolic process (GO:0046386)3.94266044
8protoporphyrinogen IX biosynthetic process (GO:0006782)3.91961157
9pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.88004876
10UV protection (GO:0009650)3.72745498
11purine nucleotide salvage (GO:0032261)3.55069308
12GDP-mannose metabolic process (GO:0019673)3.53373443
13pyrimidine nucleotide catabolic process (GO:0006244)3.45087615
14rRNA modification (GO:0000154)3.43139612
15pinocytosis (GO:0006907)3.37418264
16protein maturation by protein folding (GO:0022417)3.30136899
17nucleotide salvage (GO:0043173)3.29939916
18purine deoxyribonucleotide catabolic process (GO:0009155)3.29935772
19centriole assembly (GO:0098534)3.28294924
20ribosomal small subunit assembly (GO:0000028)3.26137450
21purine-containing compound salvage (GO:0043101)3.24486716
22keratinocyte development (GO:0003334)3.22269963
23deoxyribose phosphate metabolic process (GO:0019692)3.21640066
24heme biosynthetic process (GO:0006783)3.20747335
25nucleotide transmembrane transport (GO:1901679)3.18987835
26pentose metabolic process (GO:0019321)3.17914944
27proline biosynthetic process (GO:0006561)3.16794495
28ribosomal small subunit biogenesis (GO:0042274)3.15973024
29positive regulation of B cell differentiation (GO:0045579)3.15733872
30base-excision repair, AP site formation (GO:0006285)3.15605888
312-deoxyribonucleotide biosynthetic process (GO:0009265)3.12880229
32deoxyribose phosphate biosynthetic process (GO:0046385)3.12880229
33limb bud formation (GO:0060174)3.10140975
34mesenchymal cell differentiation involved in kidney development (GO:0072161)3.08112815
35mesenchymal cell differentiation involved in renal system development (GO:2001012)3.08112815
362-deoxyribonucleotide metabolic process (GO:0009394)3.07338216
37viral transcription (GO:0019083)3.05631142
38adenosine metabolic process (GO:0046085)3.03829177
39regulation of timing of cell differentiation (GO:0048505)3.03283015
40rRNA methylation (GO:0031167)3.03158954
41protein neddylation (GO:0045116)3.02909975
42thrombin receptor signaling pathway (GO:0070493)3.01275660
43negative regulation of B cell apoptotic process (GO:0002903)3.00446146
44definitive hemopoiesis (GO:0060216)2.99616611
45regulation of nuclear cell cycle DNA replication (GO:0033262)2.99158570
46GMP metabolic process (GO:0046037)2.92655327
47negative regulation of erythrocyte differentiation (GO:0045647)2.90900805
48granulocyte differentiation (GO:0030851)2.90712887
49heme metabolic process (GO:0042168)2.90370363
50developmental pigmentation (GO:0048066)2.90295980
51megakaryocyte development (GO:0035855)2.90172392
52translational termination (GO:0006415)2.89978604
53negative regulation of execution phase of apoptosis (GO:1900118)2.85450744
54translational elongation (GO:0006414)2.83674348
55regulation of mitochondrial translation (GO:0070129)2.83609660
56microtubule depolymerization (GO:0007019)2.83443297
57negative regulation of DNA-dependent DNA replication (GO:2000104)2.83428314
58poly(A)+ mRNA export from nucleus (GO:0016973)2.81588472
59guanosine-containing compound biosynthetic process (GO:1901070)2.81293558
60porphyrin-containing compound biosynthetic process (GO:0006779)2.80729687
61formation of translation preinitiation complex (GO:0001731)2.80546134
62preassembly of GPI anchor in ER membrane (GO:0016254)2.80106393
63folic acid metabolic process (GO:0046655)2.80089952
64detection of bacterium (GO:0016045)2.79644577
65ribosome biogenesis (GO:0042254)2.79433489
66DNA integration (GO:0015074)2.79116421
67cell differentiation involved in metanephros development (GO:0072202)2.78371829
68cornea development in camera-type eye (GO:0061303)2.77613961
69deoxyribonucleotide metabolic process (GO:0009262)2.77030725
70Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76008691
71negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.74278910
72positive regulation of uterine smooth muscle contraction (GO:0070474)2.73049340
73detection of other organism (GO:0098543)2.72110631
74nucleoside salvage (GO:0043174)2.71854060
75pseudouridine synthesis (GO:0001522)2.71258741
76platelet formation (GO:0030220)2.70354126
77protein heterotetramerization (GO:0051290)2.69417235
78pentose-phosphate shunt (GO:0006098)2.69399929
79ribonucleoprotein complex biogenesis (GO:0022613)2.69353074
80GPI anchor biosynthetic process (GO:0006506)2.69157736
81purine nucleobase metabolic process (GO:0006144)2.68075946
82proteasome assembly (GO:0043248)2.67906907
83regulation of superoxide anion generation (GO:0032928)2.67816332
84oligosaccharide catabolic process (GO:0009313)2.66120951
85adenosine receptor signaling pathway (GO:0001973)2.65907572
86regulation of B cell apoptotic process (GO:0002902)2.65399053
87negative regulation of keratinocyte proliferation (GO:0010839)2.64149083
88pharyngeal system development (GO:0060037)2.63680020
89G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.63198081
90mitochondrial calcium ion transport (GO:0006851)2.63160948
91cellular metabolic compound salvage (GO:0043094)2.63157562
92peptidyl-arginine omega-N-methylation (GO:0035247)2.62291311
93negative regulation of myoblast differentiation (GO:0045662)2.60367794
94tetrapyrrole biosynthetic process (GO:0033014)2.59510130
95L-phenylalanine metabolic process (GO:0006558)2.58578719
96erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.58578719
97positive regulation of interleukin-1 secretion (GO:0050716)2.58553901
98meiotic chromosome segregation (GO:0045132)2.58527445
99erythrocyte maturation (GO:0043249)2.58367681
100sympathetic nervous system development (GO:0048485)2.58337619
101porphyrin-containing compound metabolic process (GO:0006778)2.58055223
102oxidative phosphorylation (GO:0006119)2.57965141
103regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.57222834
104ceramide catabolic process (GO:0046514)2.56771826
105regulation of development, heterochronic (GO:0040034)2.56089106
106nucleobase-containing small molecule interconversion (GO:0015949)2.55595515
107polyol transport (GO:0015791)2.54937990
108glycosphingolipid catabolic process (GO:0046479)2.54787494
109SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.54504549
110cerebral cortex radially oriented cell migration (GO:0021799)2.54351850
111female gonad development (GO:0008585)2.53820295
112deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.53549694
113presynaptic membrane assembly (GO:0097105)2.53324043
114cranial nerve morphogenesis (GO:0021602)2.53240556
115long-chain fatty acid biosynthetic process (GO:0042759)2.52555815
116platelet aggregation (GO:0070527)2.52200155
117regulation of interleukin-8 secretion (GO:2000482)2.50190709
118lymphoid progenitor cell differentiation (GO:0002320)2.49567470
119pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.48850026
120hydrogen peroxide catabolic process (GO:0042744)2.48615227
121cell proliferation in forebrain (GO:0021846)2.48464925
122DNA ligation (GO:0006266)2.48417934
123viral life cycle (GO:0019058)2.47969341
124cotranslational protein targeting to membrane (GO:0006613)2.47673679
125protein insertion into membrane (GO:0051205)2.46955927
126mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.46329812
127DNA strand renaturation (GO:0000733)2.46240459
128positive regulation of megakaryocyte differentiation (GO:0045654)2.46230573
129DNA strand elongation (GO:0022616)2.46011776
130androgen biosynthetic process (GO:0006702)2.45900284
131DNA strand elongation involved in DNA replication (GO:0006271)2.45785573
132telomere maintenance via semi-conservative replication (GO:0032201)2.45323642
133negative regulation of homotypic cell-cell adhesion (GO:0034111)2.44872808
134extracellular negative regulation of signal transduction (GO:1900116)2.44588362
135extracellular regulation of signal transduction (GO:1900115)2.44588362
136superoxide metabolic process (GO:0006801)2.44486896
137protein targeting to ER (GO:0045047)2.43981125
138negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.43343261
139positive regulation of protein homodimerization activity (GO:0090073)2.42317239
140protein localization to endoplasmic reticulum (GO:0070972)2.42016825
141purine deoxyribonucleotide metabolic process (GO:0009151)2.41796554
142dendritic cell chemotaxis (GO:0002407)2.41533226
143positive regulation of interleukin-8 secretion (GO:2000484)2.41459541
144histamine secretion (GO:0001821)2.41292893
145dentate gyrus development (GO:0021542)2.39440589
146synapsis (GO:0007129)2.39417414
147positive regulation of interleukin-1 beta secretion (GO:0050718)2.39129165
148DNA deamination (GO:0045006)2.38419127
149spinal cord association neuron differentiation (GO:0021527)2.37923841
150nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.37207259
151snRNA metabolic process (GO:0016073)2.37185605
152fusion of sperm to egg plasma membrane (GO:0007342)2.36989678
153pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.36890194
154negative regulation of mast cell activation (GO:0033004)2.36737749
155G-protein coupled receptor internalization (GO:0002031)2.36252002
156negative regulation of cell aging (GO:0090344)2.35803162
157regulation of activation of Janus kinase activity (GO:0010533)2.35346073
158histone H3-K4 trimethylation (GO:0080182)2.35129627
159lipoxygenase pathway (GO:0019372)2.35056782
160inner ear receptor stereocilium organization (GO:0060122)2.34334180
161GPI anchor metabolic process (GO:0006505)2.34057374
162adenine nucleotide transport (GO:0051503)2.32487843
163import into cell (GO:0098657)2.30411073
164regulation of male gonad development (GO:2000018)2.29738969
165tRNA methylation (GO:0030488)2.29607511
166sphingoid metabolic process (GO:0046519)2.29449397
167negative regulation of transcription by competitive promoter binding (GO:0010944)2.29235397
168regulation of platelet aggregation (GO:0090330)2.27665976
169glycolipid catabolic process (GO:0019377)2.27499698
170opioid receptor signaling pathway (GO:0038003)2.25872648
171ganglion development (GO:0061548)2.25472657
172response to peptidoglycan (GO:0032494)2.25068291
173cellular anion homeostasis (GO:0030002)2.24029387
174regulation of dendritic cell antigen processing and presentation (GO:0002604)2.23042903
175endoderm formation (GO:0001706)2.22363709
176positive regulation of mast cell activation involved in immune response (GO:0033008)2.21598490
177positive regulation of mast cell degranulation (GO:0043306)2.21598490
178sphingolipid catabolic process (GO:0030149)2.21264080
179centriole replication (GO:0007099)2.21100389
180photoreceptor cell maintenance (GO:0045494)2.19065892
181purine ribonucleotide transport (GO:0015868)2.18832606
182amino sugar catabolic process (GO:0046348)2.18642776
183auditory receptor cell stereocilium organization (GO:0060088)2.17730843
184neutrophil activation (GO:0042119)2.17463762
185cell differentiation in spinal cord (GO:0021515)2.16873152
186purinergic nucleotide receptor signaling pathway (GO:0035590)2.16746933
187omega-hydroxylase P450 pathway (GO:0097267)2.16530754
188behavioral response to nicotine (GO:0035095)2.15858303
189postsynaptic membrane organization (GO:0001941)2.15542939
190DNA synthesis involved in DNA repair (GO:0000731)2.14797434
191spinal cord motor neuron differentiation (GO:0021522)2.14151545
192energy homeostasis (GO:0097009)2.13939629
193presynaptic membrane organization (GO:0097090)2.13441278
194ganglioside metabolic process (GO:0001573)2.10974681
195positive regulation of interleukin-17 production (GO:0032740)2.10911387

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.47376468
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41555871
3GBX2_23144817_ChIP-Seq_PC3_Human3.40212979
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.11498477
5EZH2_22144423_ChIP-Seq_EOC_Human3.01712895
6VDR_21846776_ChIP-Seq_THP-1_Human2.99489318
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.99139666
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.79041818
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.77172346
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.71555315
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.68372752
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66064688
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64305028
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.60005008
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.55540369
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42835732
17SUZ12_27294783_Chip-Seq_NPCs_Mouse2.37624088
18PCGF2_27294783_Chip-Seq_NPCs_Mouse2.35365718
19NFE2_27457419_Chip-Seq_LIVER_Mouse2.31267578
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.23989969
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.20953532
22XRN2_22483619_ChIP-Seq_HELA_Human2.07058815
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05901072
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.00796956
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99569854
26EZH2_27294783_Chip-Seq_NPCs_Mouse1.99293247
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97399103
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94196351
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.93872894
30MYC_22102868_ChIP-Seq_BL_Human1.93033231
31STAT3_18555785_Chip-Seq_ESCs_Mouse1.92418450
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92322006
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92112454
34EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.91362128
35SUZ12_18555785_Chip-Seq_ESCs_Mouse1.90660249
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.90171021
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88970829
38RNF2_27304074_Chip-Seq_NSC_Mouse1.88773345
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88715849
40VDR_22108803_ChIP-Seq_LS180_Human1.88629628
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88384519
42TAF15_26573619_Chip-Seq_HEK293_Human1.87507556
43DCP1A_22483619_ChIP-Seq_HELA_Human1.85375473
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.84120003
45E2F1_18555785_Chip-Seq_ESCs_Mouse1.83924808
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.83034303
47NMYC_18555785_Chip-Seq_ESCs_Mouse1.83006026
48SCL_19346495_ChIP-Seq_HPC-7_Human1.82415795
49VDR_24763502_ChIP-Seq_THP-1_Human1.81366296
50EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.81186922
51P53_22387025_ChIP-Seq_ESCs_Mouse1.81008752
52P300_18555785_Chip-Seq_ESCs_Mouse1.79904549
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.79032073
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78948115
55RUNX1_27457419_Chip-Seq_LIVER_Mouse1.78039062
56CMYC_18555785_Chip-Seq_ESCs_Mouse1.69312624
57KLF4_18555785_Chip-Seq_ESCs_Mouse1.69163265
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68570469
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.68168862
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67957149
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67864078
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.67581678
63IRF1_19129219_ChIP-ChIP_H3396_Human1.65120052
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64963272
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.64755604
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64668667
67SOX2_18555785_Chip-Seq_ESCs_Mouse1.64665808
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64635667
69ZFX_18555785_Chip-Seq_ESCs_Mouse1.64585782
70* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64412445
71OCT4_18555785_Chip-Seq_ESCs_Mouse1.64129426
72GABP_19822575_ChIP-Seq_HepG2_Human1.62917055
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.61979239
74* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.60660209
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.60301736
76* LXR_22292898_ChIP-Seq_THP-1_Human1.59939413
77ZNF263_19887448_ChIP-Seq_K562_Human1.59597641
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59188022
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59012957
80PU1_27457419_Chip-Seq_LIVER_Mouse1.58856203
81FOXP3_21729870_ChIP-Seq_TREG_Human1.58855269
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.58632840
83ESRRB_18555785_Chip-Seq_ESCs_Mouse1.58465611
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58187048
85P300_19829295_ChIP-Seq_ESCs_Human1.57241739
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56491759
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55481471
88MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55012376
89SMAD1_18555785_Chip-Seq_ESCs_Mouse1.54963900
90EST1_17652178_ChIP-ChIP_JURKAT_Human1.54517737
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.52194763
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51674279
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50797185
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50372926
95NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50185616
96CTCF_18555785_Chip-Seq_ESCs_Mouse1.49382244
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48416884
98P68_20966046_ChIP-Seq_HELA_Human1.47791295
99IGF1R_20145208_ChIP-Seq_DFB_Human1.47761056
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.47744923
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46849951
102ELK3_25401928_ChIP-Seq_HUVEC_Human1.46380147
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46022062
104EZH2_27294783_Chip-Seq_ESCs_Mouse1.45843393
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45327391
106SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44679663
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44392114
108JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44056043
109SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43977674
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.42323462
111CRX_20693478_ChIP-Seq_RETINA_Mouse1.41279773
112TP63_19390658_ChIP-ChIP_HaCaT_Human1.40985553
113KDM5A_27292631_Chip-Seq_BREAST_Human1.39246715
114MAF_26560356_Chip-Seq_TH1_Human1.39004788
115BCL6_27268052_Chip-Seq_Bcells_Human1.38946568
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38245263
117ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37748281
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37423006
119OCT4_21477851_ChIP-Seq_ESCs_Mouse1.37102778
120ER_23166858_ChIP-Seq_MCF-7_Human1.36959914
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36621320
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36572222
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36186345
124CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35839390
125* TTF2_22483619_ChIP-Seq_HELA_Human1.35616595
126SPI1_23547873_ChIP-Seq_NB4_Human1.35559739
127ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35489668
128RNF2_27304074_Chip-Seq_ESCs_Mouse1.35006059
129YY1_21170310_ChIP-Seq_MESCs_Mouse1.34347027
130SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34009618
131EWS_26573619_Chip-Seq_HEK293_Human1.33529430
132VDR_23849224_ChIP-Seq_CD4+_Human1.32998150
133RUNX1_22412390_ChIP-Seq_EML_Mouse1.32393361
134PIAS1_25552417_ChIP-Seq_VCAP_Human1.32002641
135MAF_26560356_Chip-Seq_TH2_Human1.31459911
136BCOR_27268052_Chip-Seq_Bcells_Human1.30965252
137UTX_26944678_Chip-Seq_JUKART_Human1.30862562
138SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30570778
139AR_21572438_ChIP-Seq_LNCaP_Human1.29780570
140CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29569664
141* TET1_21451524_ChIP-Seq_MESCs_Mouse1.29488871
142ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29329469
143CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27874456
144CIITA_25753668_ChIP-Seq_RAJI_Human1.27508046
145SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27370667
146EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27158656
147RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27158656
148MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26864185
149FUS_26573619_Chip-Seq_HEK293_Human1.26849324
150KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26707053
151SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.26492846
152NCOR1_26117541_ChIP-Seq_K562_Human1.25581662
153HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24828772
154LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23654405
155TFEB_21752829_ChIP-Seq_HELA_Human1.22696817
156CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22460522
157MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21887887
158GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18015179
159POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17913154
160HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17475017
161E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17380630
162UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16689635
163CTCF_21964334_Chip-Seq_Bcells_Human1.16628249
164RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16370229
165TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15561517
166E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15396114
167PHF8_20622854_ChIP-Seq_HELA_Human1.14747310
168KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14354682
169CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13340862
170GATA1_19941827_ChIP-Seq_MEL_Mouse1.13051387
171SMAD3_21741376_ChIP-Seq_EPCs_Human1.12584531
172TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12470663
173POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12470663
174* FOXP1_21924763_ChIP-Seq_HESCs_Human1.11910628
175MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11438050
176SMAD4_21799915_ChIP-Seq_A2780_Human1.11390395
177ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11360469
178CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11312812
179TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11086316
180CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10240478
181KDM2B_26808549_Chip-Seq_REH_Human1.09660811
182KAP1_22055183_ChIP-Seq_ESCs_Mouse1.08486910
183GATA1_22025678_ChIP-Seq_K562_Human1.08268617
184TP53_18474530_ChIP-ChIP_U2OS_Human1.07829053
185E2F1_20622854_ChIP-Seq_HELA_Human1.07817844
186PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06982282
187MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06958179
188MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06762457
189FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06742266
190TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04557253
191CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03512017
192NOTCH1_21737748_ChIP-Seq_TLL_Human1.02066367
193LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01905353
194SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00646135
195EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98070269
196SMAD_19615063_ChIP-ChIP_OVARY_Human0.96673821
197CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95815649
198RUNX2_22187159_ChIP-Seq_PCA_Human0.95413290

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology5.39949851
2MP0006292_abnormal_olfactory_placode4.37881734
3MP0001188_hyperpigmentation4.01396505
4MP0003806_abnormal_nucleotide_metabolis3.54263068
5MP0000566_synostosis3.26032498
6MP0002102_abnormal_ear_morphology3.14946095
7MP0005058_abnormal_lysosome_morphology3.11993732
8MP0001545_abnormal_hematopoietic_system2.99422197
9MP0005397_hematopoietic_system_phenotyp2.99422197
10MP0003136_yellow_coat_color2.96754055
11MP0003656_abnormal_erythrocyte_physiolo2.78673805
12MP0005409_darkened_coat_color2.77381457
13MP0001986_abnormal_taste_sensitivity2.54681731
14MP0005171_absent_coat_pigmentation2.52408432
15MP0004381_abnormal_hair_follicle2.47526392
16MP0003303_peritoneal_inflammation2.31407747
17MP0000015_abnormal_ear_pigmentation2.30065663
18MP0003111_abnormal_nucleus_morphology2.23953108
19MP0005645_abnormal_hypothalamus_physiol2.20731224
20MP0003172_abnormal_lysosome_physiology2.15114320
21MP0002277_abnormal_respiratory_mucosa2.09798585
22MP0002132_abnormal_respiratory_system2.05509108
23MP0000465_gastrointestinal_hemorrhage2.05044049
24MP0005410_abnormal_fertilization2.04099067
25MP0003186_abnormal_redox_activity2.01152394
26MP0002009_preneoplasia1.99866171
27MP0005646_abnormal_pituitary_gland1.96708584
28MP0005083_abnormal_biliary_tract1.96253625
29MP0004808_abnormal_hematopoietic_stem1.94299551
30MP0006036_abnormal_mitochondrial_physio1.89131322
31MP0001661_extended_life_span1.88636213
32MP0010094_abnormal_chromosome_stability1.88457904
33MP0003941_abnormal_skin_development1.86423848
34MP0009278_abnormal_bone_marrow1.85558801
35MP0000678_abnormal_parathyroid_gland1.84991571
36MP0004742_abnormal_vestibular_system1.82783884
37MP0003436_decreased_susceptibility_to1.81409845
38MP0008875_abnormal_xenobiotic_pharmacok1.80812695
39MP0008789_abnormal_olfactory_epithelium1.80557763
40MP0009333_abnormal_splenocyte_physiolog1.77950588
41MP0004957_abnormal_blastocyst_morpholog1.77425942
42MP0008057_abnormal_DNA_replication1.75928946
43MP0003077_abnormal_cell_cycle1.73362294
44MP0005174_abnormal_tail_pigmentation1.72838679
45MP0002876_abnormal_thyroid_physiology1.70376357
46MP0008007_abnormal_cellular_replicative1.70232834
47MP0003787_abnormal_imprinting1.69528693
48MP0009379_abnormal_foot_pigmentation1.68409087
49MP0000358_abnormal_cell_content/1.67930958
50MP0005451_abnormal_body_composition1.66766982
51MP0005501_abnormal_skin_physiology1.65609605
52MP0002396_abnormal_hematopoietic_system1.65310164
53MP0000372_irregular_coat_pigmentation1.59552508
54MP0003938_abnormal_ear_development1.59431851
55MP0004185_abnormal_adipocyte_glucose1.59400145
56MP0003724_increased_susceptibility_to1.57461855
57MP0002638_abnormal_pupillary_reflex1.56723306
58MP0001764_abnormal_homeostasis1.55351464
59MP0002148_abnormal_hypersensitivity_rea1.54502962
60MP0000049_abnormal_middle_ear1.51444737
61MP0002398_abnormal_bone_marrow1.51257105
62MP0008260_abnormal_autophagy1.50616792
63MP0002019_abnormal_tumor_incidence1.49673826
64MP0000026_abnormal_inner_ear1.47753165
65MP0008058_abnormal_DNA_repair1.46816835
66MP0000681_abnormal_thyroid_gland1.44513127
67MP0005499_abnormal_olfactory_system1.44065385
68MP0005394_taste/olfaction_phenotype1.44065385
69MP0003191_abnormal_cellular_cholesterol1.35270499
70MP0001835_abnormal_antigen_presentation1.35243415
71MP0003880_abnormal_central_pattern1.34495302
72MP0006035_abnormal_mitochondrial_morpho1.32822451
73MP0009785_altered_susceptibility_to1.31974538
74MP0002429_abnormal_blood_cell1.30751884
75MP0000631_abnormal_neuroendocrine_gland1.30082268
76MP0005671_abnormal_response_to1.29941993
77MP0003693_abnormal_embryo_hatching1.29678254
78MP0002249_abnormal_larynx_morphology1.28325750
79MP0008004_abnormal_stomach_pH1.27752737
80MP0002722_abnormal_immune_system1.27730582
81MP0005075_abnormal_melanosome_morpholog1.26437225
82MP0010386_abnormal_urinary_bladder1.26415560
83MP0000313_abnormal_cell_death1.25134025
84MP0005379_endocrine/exocrine_gland_phen1.24565138
85MP0000689_abnormal_spleen_morphology1.22996385
86MP0002938_white_spotting1.20175264
87MP0005084_abnormal_gallbladder_morpholo1.19348007
88MP0002095_abnormal_skin_pigmentation1.17133886
89MP0001963_abnormal_hearing_physiology1.17056517
90MP0000762_abnormal_tongue_morphology1.15667383
91MP0008932_abnormal_embryonic_tissue1.15480181
92MP0005666_abnormal_adipose_tissue1.13778182
93MP0001486_abnormal_startle_reflex1.13022629
94MP0003566_abnormal_cell_adhesion1.12349047
95MP0009697_abnormal_copulation1.11937901
96MP0006276_abnormal_autonomic_nervous1.11565392
97MP0009840_abnormal_foam_cell1.11351706
98MP0000613_abnormal_salivary_gland1.09667574
99MP0001853_heart_inflammation1.09034332
100MP0004782_abnormal_surfactant_physiolog1.08970200
101MP0008995_early_reproductive_senescence1.08938377
102MP0000490_abnormal_crypts_of1.08907747
103MP0000858_altered_metastatic_potential1.08226515
104MP0002735_abnormal_chemical_nociception1.07879914
105MP0005360_urolithiasis1.07491461
106MP0000383_abnormal_hair_follicle1.04450522
107MP0005551_abnormal_eye_electrophysiolog1.04230343
108MP0005423_abnormal_somatic_nervous1.03281212
109MP0002163_abnormal_gland_morphology1.02700674
110MP0002098_abnormal_vibrissa_morphology1.02669302
111MP0002751_abnormal_autonomic_nervous1.02217631
112MP0006072_abnormal_retinal_apoptosis1.01289889
113MP0000343_altered_response_to1.00439774
114MP0000598_abnormal_liver_morphology0.99708151
115MP0003195_calcinosis0.99517297
116MP0001346_abnormal_lacrimal_gland0.96514342
117MP0002723_abnormal_immune_serum0.96414197
118MP0005584_abnormal_enzyme/coenzyme_acti0.96119284
119MP0000716_abnormal_immune_system0.96046498
120MP0002420_abnormal_adaptive_immunity0.95777922
121MP0002877_abnormal_melanocyte_morpholog0.95578776
122MP0002080_prenatal_lethality0.95516704
123MP0001905_abnormal_dopamine_level0.95367452
124MP0001819_abnormal_immune_cell0.95312460
125MP0003786_premature_aging0.94880991
126MP0003075_altered_response_to0.94636441
127MP0008877_abnormal_DNA_methylation0.94279309
128MP0005253_abnormal_eye_physiology0.92664590
129MP0009931_abnormal_skin_appearance0.92372101
130MP0002139_abnormal_hepatobiliary_system0.92113116
131MP0005165_increased_susceptibility_to0.91949366
132MP0001984_abnormal_olfaction0.91730938
133MP0001502_abnormal_circadian_rhythm0.90974358
134MP0002177_abnormal_outer_ear0.89773830
135MP0005384_cellular_phenotype0.89302882
136MP0008469_abnormal_protein_level0.88236281
137MP0005387_immune_system_phenotype0.87286196
138MP0001790_abnormal_immune_system0.87286196
139MP0009764_decreased_sensitivity_to0.86407701
140MP0008873_increased_physiological_sensi0.86238712
141MP0002452_abnormal_antigen_presenting0.85787862
142MP0000350_abnormal_cell_proliferation0.85749277
143MP0008874_decreased_physiological_sensi0.84826273
144MP0005319_abnormal_enzyme/_coenzyme0.84413968
145MP0002419_abnormal_innate_immunity0.84369182
146MP0002233_abnormal_nose_morphology0.84007547
147MP0003763_abnormal_thymus_physiology0.83142310
148MP0003718_maternal_effect0.82474966
149MP0002736_abnormal_nociception_after0.82326499
150MP0005621_abnormal_cell_physiology0.81965190
151MP0002138_abnormal_hepatobiliary_system0.81878216
152MP0000609_abnormal_liver_physiology0.81612873
153MP0005000_abnormal_immune_tolerance0.81449393
154MP0004147_increased_porphyrin_level0.81352724
155MP0005647_abnormal_sex_gland0.80748852
156MP0001485_abnormal_pinna_reflex0.79927615
157MP0003453_abnormal_keratinocyte_physiol0.79815889
158MP0005025_abnormal_response_to0.78677588
159MP0005670_abnormal_white_adipose0.78121043
160MP0003315_abnormal_perineum_morphology0.77931975
161MP0001919_abnormal_reproductive_system0.77487430
162MP0006054_spinal_hemorrhage0.76867100
163MP0000470_abnormal_stomach_morphology0.76831749
164MP0002160_abnormal_reproductive_system0.76750944
165MP0009250_abnormal_appendicular_skeleto0.76454320
166MP0001845_abnormal_inflammatory_respons0.75950720
167MP0002933_joint_inflammation0.74763271
168MP0005365_abnormal_bile_salt0.74561261
169MP0001186_pigmentation_phenotype0.73315910
170MP0005332_abnormal_amino_acid0.72951511
171MP0000703_abnormal_thymus_morphology0.72674234
172MP0009763_increased_sensitivity_to0.71621049
173MP0002752_abnormal_somatic_nervous0.71618813
174MP0003937_abnormal_limbs/digits/tail_de0.68969435
175MP0002557_abnormal_social/conspecific_i0.68437028
176MP0005389_reproductive_system_phenotype0.68046671
177MP0004019_abnormal_vitamin_homeostasis0.67786582
178MP0005503_abnormal_tendon_morphology0.64677798
179MP0004142_abnormal_muscle_tone0.64281053
180MP0002272_abnormal_nervous_system0.64110016

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)5.81184589
2Prolonged bleeding time (HP:0003010)5.40039343
3Chromosomal breakage induced by crosslinking agents (HP:0003221)5.16490830
4Abnormality of the heme biosynthetic pathway (HP:0010472)4.64429019
5Chromsome breakage (HP:0040012)4.53147330
6Epistaxis (HP:0000421)4.36361536
7Purpura (HP:0000979)4.17566886
8Abnormal platelet function (HP:0011869)3.89379738
9Impaired platelet aggregation (HP:0003540)3.89379738
10Increased mean platelet volume (HP:0011877)3.82810465
11Abnormality of the renal collecting system (HP:0004742)3.78188094
12Menorrhagia (HP:0000132)3.72903681
13Thrombocytosis (HP:0001894)3.70792319
14Abnormal platelet volume (HP:0011876)3.69436531
15Duplicated collecting system (HP:0000081)3.53584259
16Abnormal number of erythroid precursors (HP:0012131)3.25874406
17Hepatocellular necrosis (HP:0001404)3.14741052
18Testicular atrophy (HP:0000029)3.13064967
19Septo-optic dysplasia (HP:0100842)3.12387950
20True hermaphroditism (HP:0010459)3.07062761
21Abnormal gallbladder physiology (HP:0012438)3.05443011
22Cholecystitis (HP:0001082)3.05443011
23Abnormality of cells of the erythroid lineage (HP:0012130)3.04805062
24Dyschromatopsia (HP:0007641)3.03045359
25Hepatic necrosis (HP:0002605)2.93043804
26Microvesicular hepatic steatosis (HP:0001414)2.86262074
27Abnormality of the preputium (HP:0100587)2.85580311
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.84296254
29Progressive muscle weakness (HP:0003323)2.83182818
30Paralysis (HP:0003470)2.81187972
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.80203285
32Absent/shortened dynein arms (HP:0200106)2.80203285
33Increased serum ferritin (HP:0003281)2.80040604
34Aplastic anemia (HP:0001915)2.78408781
35Generalized aminoaciduria (HP:0002909)2.77485600
36Gingival bleeding (HP:0000225)2.74413836
37Congenital sensorineural hearing impairment (HP:0008527)2.73546814
38White forelock (HP:0002211)2.70137263
39Aplasia/Hypoplasia of the fovea (HP:0008060)2.67391329
40Hypoplasia of the fovea (HP:0007750)2.67391329
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.64802280
42Patchy hypopigmentation of hair (HP:0011365)2.64693392
43Renal cortical cysts (HP:0000803)2.63727425
44Increased intramyocellular lipid droplets (HP:0012240)2.61514619
45Abnormality of iron homeostasis (HP:0011031)2.61319176
46Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.60468426
47Reticulocytosis (HP:0001923)2.58927856
48Abnormality of DNA repair (HP:0003254)2.58893209
49Osteomalacia (HP:0002749)2.56881331
50Increased serum pyruvate (HP:0003542)2.54888129
51Pancreatic fibrosis (HP:0100732)2.54867610
52Hepatosplenomegaly (HP:0001433)2.54533572
53Cholelithiasis (HP:0001081)2.52743864
54Abnormality of glycolysis (HP:0004366)2.52505228
55Clubbing of toes (HP:0100760)2.52417884
56Ragged-red muscle fibers (HP:0003200)2.52179551
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.52064427
58Mitochondrial inheritance (HP:0001427)2.50667722
59Upper limb muscle weakness (HP:0003484)2.49932257
60Hypothermia (HP:0002045)2.48491838
61Meckel diverticulum (HP:0002245)2.48240130
62Hypertensive crisis (HP:0100735)2.45653897
63Increased hepatocellular lipid droplets (HP:0006565)2.45252911
64Abnormality of the prostate (HP:0008775)2.43686817
65Pancreatic cysts (HP:0001737)2.42932777
66Abnormal ciliary motility (HP:0012262)2.40673176
67Decreased central vision (HP:0007663)2.39797460
68Reduced antithrombin III activity (HP:0001976)2.39464058
69Congenital stationary night blindness (HP:0007642)2.39427081
70Febrile seizures (HP:0002373)2.38778168
71Increased muscle lipid content (HP:0009058)2.38707066
72Abnormal respiratory epithelium morphology (HP:0012253)2.37889147
73Abnormal respiratory motile cilium morphology (HP:0005938)2.37889147
74Abnormality of the ileum (HP:0001549)2.36806054
75Increased CSF lactate (HP:0002490)2.35416396
76Prostate neoplasm (HP:0100787)2.33704626
77Respiratory difficulties (HP:0002880)2.31881266
78Optic nerve hypoplasia (HP:0000609)2.30327406
79Acute encephalopathy (HP:0006846)2.26654333
80Nasolacrimal duct obstruction (HP:0000579)2.25912839
81Joint hemorrhage (HP:0005261)2.23921289
82Lipid accumulation in hepatocytes (HP:0006561)2.23034859
83Male pseudohermaphroditism (HP:0000037)2.22961629
84Stomach cancer (HP:0012126)2.21463698
85Increased serum lactate (HP:0002151)2.21427487
86Abnormal mitochondria in muscle tissue (HP:0008316)2.19113296
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18933725
88Abnormal protein N-linked glycosylation (HP:0012347)2.18933725
89Abnormal protein glycosylation (HP:0012346)2.18933725
90Abnormal glycosylation (HP:0012345)2.18933725
91Abnormality of transition element cation homeostasis (HP:0011030)2.18840559
92Lip pit (HP:0100267)2.18756144
93Parakeratosis (HP:0001036)2.18736140
94Increased neuronal autofluorescent lipopigment (HP:0002074)2.18687175
95Aplasia cutis congenita (HP:0001057)2.16872418
96Rough bone trabeculation (HP:0100670)2.15736759
97Abnormality of reticulocytes (HP:0004312)2.14578420
98Exertional dyspnea (HP:0002875)2.14175214
99Chronic mucocutaneous candidiasis (HP:0002728)2.13625207
100Recurrent cutaneous fungal infections (HP:0011370)2.13625207
101Absent septum pellucidum (HP:0001331)2.13578248
102Conical tooth (HP:0000698)2.12293031
103Tubulointerstitial nephritis (HP:0001970)2.11799101
104Elevated erythrocyte sedimentation rate (HP:0003565)2.10898148
105Poikilocytosis (HP:0004447)2.10043328
106Poikiloderma (HP:0001029)2.09632760
107Abnormal gallbladder morphology (HP:0012437)2.08638653
108Dysostosis multiplex (HP:0000943)2.08111987
109Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08025972
110Medial flaring of the eyebrow (HP:0010747)2.07572890
111Nausea (HP:0002018)2.06948254
112Abnormality of the fovea (HP:0000493)2.05865299
113Squamous cell carcinoma (HP:0002860)2.05761703
114Duplication of thumb phalanx (HP:0009942)2.05574411
115Pallor (HP:0000980)2.04763817
116Abnormality of lateral ventricle (HP:0030047)2.02255779
117Lactic acidosis (HP:0003128)2.02006389
118Acute necrotizing encephalopathy (HP:0006965)2.01664483
119Abnormality of chromosome stability (HP:0003220)2.00405511
120Morphological abnormality of the middle ear (HP:0008609)2.00079755
121Obstructive lung disease (HP:0006536)1.98128395
122Chronic obstructive pulmonary disease (HP:0006510)1.98128395
123Abnormal delayed hypersensitivity skin test (HP:0002963)1.97509428
124Abnormal trabecular bone morphology (HP:0100671)1.97391332
125Increased cerebral lipofuscin (HP:0011813)1.97371305
126Abnormality of the septum pellucidum (HP:0007375)1.97291454
127Median cleft lip (HP:0000161)1.96521822
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95768364
129Panhypogammaglobulinemia (HP:0003139)1.95286047
130Abnormality of the common coagulation pathway (HP:0010990)1.94613666
131Abnormal respiratory motile cilium physiology (HP:0012261)1.94060262
132Abnormality of renal resorption (HP:0011038)1.93995765
133Abnormality of the renal medulla (HP:0100957)1.93817931
134Exercise intolerance (HP:0003546)1.93145979
135Pancytopenia (HP:0001876)1.92511000
136Xerostomia (HP:0000217)1.92322990
137Nephronophthisis (HP:0000090)1.91897747
138Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91601574
139Hemorrhage of the eye (HP:0011885)1.90662104
140Abnormality of the renal cortex (HP:0011035)1.89275405
141Preaxial hand polydactyly (HP:0001177)1.88824604
142Postaxial foot polydactyly (HP:0001830)1.87963652
143Abnormality of the lacrimal duct (HP:0011481)1.87470048
144Retrobulbar optic neuritis (HP:0100654)1.87000302
145Optic neuritis (HP:0100653)1.87000302
146Ectopic kidney (HP:0000086)1.86119602
147Congenital hepatic fibrosis (HP:0002612)1.86112242
148Abnormality of the nasal septum (HP:0000419)1.85206741
149Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84975415
150Type I transferrin isoform profile (HP:0003642)1.84970246
151Conjugated hyperbilirubinemia (HP:0002908)1.84869559
152Pulmonary artery stenosis (HP:0004415)1.84832546
153Attenuation of retinal blood vessels (HP:0007843)1.84741604
154Renal Fanconi syndrome (HP:0001994)1.84725544
155Oligohydramnios (HP:0001562)1.84627967
156Vacuolated lymphocytes (HP:0001922)1.84491946
157Abnormality of the intrinsic pathway (HP:0010989)1.83396958
158Nephrogenic diabetes insipidus (HP:0009806)1.82486215
159Bruising susceptibility (HP:0000978)1.82173038
160Polycythemia (HP:0001901)1.81838737
161Hyperammonemia (HP:0001987)1.81634146
162Myelodysplasia (HP:0002863)1.81544566
163Cutaneous photosensitivity (HP:0000992)1.80927224
164Abnormality of aromatic amino acid family metabolism (HP:0004338)1.80065940
1653-Methylglutaconic aciduria (HP:0003535)1.79716770
166Upper motor neuron abnormality (HP:0002127)1.79072790
167Reticulocytopenia (HP:0001896)1.78870256
168Submucous cleft hard palate (HP:0000176)1.78754908
169Type 2 muscle fiber atrophy (HP:0003554)1.78180094
170Rhabdomyolysis (HP:0003201)1.77320711
171Recurrent pneumonia (HP:0006532)1.76303471
172Anteriorly placed anus (HP:0001545)1.76256821
173Male infertility (HP:0003251)1.75678235
174Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75118722
175Agammaglobulinemia (HP:0004432)1.75008516
176Increased corneal curvature (HP:0100692)1.74656845
177Keratoconus (HP:0000563)1.74656845
178Thyroid-stimulating hormone excess (HP:0002925)1.74600942
179Cheilitis (HP:0100825)1.74034549
180Acanthocytosis (HP:0001927)1.73958696
181Seborrheic dermatitis (HP:0001051)1.73478887
182Atelectasis (HP:0100750)1.72091621
183Triphalangeal thumb (HP:0001199)1.70846547
184Aplasia/Hypoplasia of the lens (HP:0008063)1.70126870
185Abnormality of the gallbladder (HP:0005264)1.69456856
186Aganglionic megacolon (HP:0002251)1.69318481
187Recurrent abscess formation (HP:0002722)1.69096233
188Opisthotonus (HP:0002179)1.68754355
189Abnormality of incisor morphology (HP:0011063)1.68687240
190Abnormality of the nasolacrimal system (HP:0000614)1.68567030
191Hypertriglyceridemia (HP:0002155)1.67612309
192Sex reversal (HP:0012245)1.66793142
193Abnormal sex determination (HP:0012244)1.66793142
194Increased IgM level (HP:0003496)1.65770499
195Abnormal hair whorl (HP:0010721)1.65147989

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.64742360
2CASK3.50338493
3STK163.24142947
4ZAK3.23040386
5IRAK33.02151482
6IRAK42.83998440
7TESK22.69258263
8TNIK2.66547349
9MAP2K32.55971098
10BCKDK2.46453071
11INSRR2.35796507
12EIF2AK12.30842871
13MKNK22.30005585
14SMG12.27407092
15NUAK12.10357174
16ERN12.05929989
17TXK2.02598347
18ADRBK21.97515559
19PRPF4B1.91551222
20GRK11.86302701
21MAP2K71.80988159
22MAP3K141.80171429
23EIF2AK21.76361007
24BLK1.75003759
25BMPR21.73805950
26NEK61.73682951
27MKNK11.65374970
28PLK41.59418740
29YES11.58993924
30SIK31.58546400
31ARAF1.54884032
32SCYL21.52982925
33MAP3K111.50681229
34TEC1.47136101
35BMPR1B1.44185033
36IRAK11.41705534
37IRAK21.40612100
38CLK11.39572885
39BMX1.38715738
40AURKA1.37670155
41FLT31.37632758
42GRK61.37302707
43TNK21.33890040
44MAPK151.33674744
45DAPK11.33327724
46CDK31.33303118
47ICK1.32973087
48CDC71.31672146
49BUB11.31405599
50PDK21.29168396
51ILK1.26230921
52ABL21.23693903
53MST41.18842961
54TESK11.17175527
55IKBKE1.16775269
56MAPK131.15636976
57NLK1.15124009
58PBK1.14968049
59VRK11.13400397
60ZAP701.09949235
61CDK71.09532048
62SRPK11.08839138
63BRSK21.08421178
64MATK1.03756954
65DAPK31.03501663
66KDR1.02502135
67TBK11.01320440
68AKT31.01204982
69GRK71.00769478
70IKBKB0.93659864
71FES0.93484713
72PIK3CA0.91830648
73BCR0.91460894
74RPS6KA40.90807529
75PAK10.90649229
76PKN10.89571876
77SGK20.88973602
78MUSK0.87982817
79CCNB10.87882528
80BRAF0.87791362
81TRIB30.83212569
82MARK10.81184283
83BRSK10.80837493
84ERBB30.80096830
85TLK10.79326363
86TIE10.79259427
87GRK50.78935562
88STK390.78776663
89RAF10.78587768
90NEK10.78069842
91CSF1R0.76661033
92CDK80.76338782
93JAK30.75186463
94DYRK20.74906847
95TRPM70.74455471
96TAOK20.73876019
97SGK4940.72949085
98SGK2230.72949085
99PRKCE0.72218404
100PRKD30.70699738
101STK38L0.70297560
102PDPK10.65760111
103MAP3K60.65055750
104MAPKAPK50.64307708
105RIPK40.64051383
106PIM20.63026854
107CDK40.62752025
108CSNK1G30.61244448
109MAPK110.60934901
110LYN0.60806469
111PIK3CG0.60651487
112OXSR10.60199145
113MAP3K80.59635717
114LRRK20.59113491
115CHUK0.58828631
116RPS6KB20.58052171
117RPS6KA50.57741473
118MAP3K30.56518774
119DYRK1A0.54686533
120BTK0.54271415
121SIK10.53952663
122MYLK0.53365338
123WNK30.51434055
124KIT0.50176315
125DYRK30.49094060
126PAK40.48792099
127PINK10.46732477
128MAP4K10.46672566
129RPS6KL10.46012907
130RPS6KC10.46012907
131CDK60.45411953
132PRKCI0.45293503
133CAMK2B0.45020588
134TAOK10.42083534
135PTK2B0.41610860
136SIK20.40786345
137CAMK2D0.40486445
138MAPKAPK30.40331252
139PKN20.39655488
140CSNK2A10.39602812
141EPHB20.38729597
142CAMK2A0.38499812
143MAP3K50.38220274
144PRKCQ0.37062727
145AURKB0.36639778
146NEK90.35938703
147EPHA30.35857872
148PRKD20.35315015
149PRKCD0.34936837
150EPHA20.34735607
151MAPK70.34236812
152SYK0.34104979
153ADRBK10.33748706
154PLK20.33435116
155RPS6KA20.33258998
156CSNK1A10.32679124
157NME20.32110839
158RPS6KA60.31901565
159HCK0.31849640
160HIPK20.31571768
161CHEK20.31530231
162PRKG10.31304050
163MAP2K20.30879830
164TTK0.30176027
165PRKACA0.28491374
166LCK0.27686330
167WNK40.27353680
168PLK30.27330505
169PIM10.26787055
170STK40.26453988
171ATR0.25337244

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.30361476
2Fanconi anemia pathway_Homo sapiens_hsa034602.63255193
3Glutathione metabolism_Homo sapiens_hsa004802.08251947
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07377915
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03017253
6Pentose phosphate pathway_Homo sapiens_hsa000302.01569833
7Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.99389084
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96299381
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.93178357
10Graft-versus-host disease_Homo sapiens_hsa053321.91925685
11Homologous recombination_Homo sapiens_hsa034401.87414522
12Sphingolipid metabolism_Homo sapiens_hsa006001.82855568
13Phototransduction_Homo sapiens_hsa047441.82182569
14Arachidonic acid metabolism_Homo sapiens_hsa005901.79738237
15Protein export_Homo sapiens_hsa030601.78984583
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.75249385
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.73606984
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73327543
19Allograft rejection_Homo sapiens_hsa053301.73056331
20Biosynthesis of amino acids_Homo sapiens_hsa012301.71188941
21Nicotine addiction_Homo sapiens_hsa050331.70606214
22Non-homologous end-joining_Homo sapiens_hsa034501.69522255
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69217788
24Primary immunodeficiency_Homo sapiens_hsa053401.67938674
25Autoimmune thyroid disease_Homo sapiens_hsa053201.66735413
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62751893
27Fructose and mannose metabolism_Homo sapiens_hsa000511.59346826
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.51133126
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50014136
30* Glycosaminoglycan degradation_Homo sapiens_hsa005311.49501245
31Taste transduction_Homo sapiens_hsa047421.43293299
32RNA polymerase_Homo sapiens_hsa030201.39245691
33N-Glycan biosynthesis_Homo sapiens_hsa005101.37101087
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36089887
35Asthma_Homo sapiens_hsa053101.34386345
36Basal transcription factors_Homo sapiens_hsa030221.32305566
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32156237
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.31311556
39Galactose metabolism_Homo sapiens_hsa000521.31194666
40Ether lipid metabolism_Homo sapiens_hsa005651.30791854
41Platelet activation_Homo sapiens_hsa046111.29553601
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27159445
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25436898
44Oxidative phosphorylation_Homo sapiens_hsa001901.24704741
45Carbon metabolism_Homo sapiens_hsa012001.22528442
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.22199898
47Hematopoietic cell lineage_Homo sapiens_hsa046401.19649817
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.19614922
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16814711
50Other glycan degradation_Homo sapiens_hsa005111.16662593
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.15908274
52Rheumatoid arthritis_Homo sapiens_hsa053231.15161245
53RNA transport_Homo sapiens_hsa030131.14226896
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11621434
55Linoleic acid metabolism_Homo sapiens_hsa005911.11288749
56Pyruvate metabolism_Homo sapiens_hsa006201.08374096
57Lysosome_Homo sapiens_hsa041421.07486532
58Serotonergic synapse_Homo sapiens_hsa047261.07125076
59Cell cycle_Homo sapiens_hsa041101.04774627
60Base excision repair_Homo sapiens_hsa034101.04279678
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04239591
62Measles_Homo sapiens_hsa051621.00391621
63Acute myeloid leukemia_Homo sapiens_hsa052210.98942178
64Morphine addiction_Homo sapiens_hsa050320.97403546
65Mismatch repair_Homo sapiens_hsa034300.97400051
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97134340
67Pyrimidine metabolism_Homo sapiens_hsa002400.96619045
68Bladder cancer_Homo sapiens_hsa052190.94801110
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94379144
70Systemic lupus erythematosus_Homo sapiens_hsa053220.94325308
71DNA replication_Homo sapiens_hsa030300.92882189
72Malaria_Homo sapiens_hsa051440.92337624
73Retinol metabolism_Homo sapiens_hsa008300.92200624
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91769007
75Nucleotide excision repair_Homo sapiens_hsa034200.91513858
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91075680
77Ribosome_Homo sapiens_hsa030100.91049392
78Leishmaniasis_Homo sapiens_hsa051400.90087204
79One carbon pool by folate_Homo sapiens_hsa006700.89836560
80Purine metabolism_Homo sapiens_hsa002300.89598324
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88429644
82Renin-angiotensin system_Homo sapiens_hsa046140.85136596
83Sulfur metabolism_Homo sapiens_hsa009200.84801851
84Fatty acid elongation_Homo sapiens_hsa000620.83176277
85Steroid biosynthesis_Homo sapiens_hsa001000.80642325
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80403865
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.78048707
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77425341
89* Metabolic pathways_Homo sapiens_hsa011000.77395566
90Shigellosis_Homo sapiens_hsa051310.77081803
91Regulation of autophagy_Homo sapiens_hsa041400.74729502
92Type I diabetes mellitus_Homo sapiens_hsa049400.74693345
93Huntingtons disease_Homo sapiens_hsa050160.70896362
94Alzheimers disease_Homo sapiens_hsa050100.70367255
95Parkinsons disease_Homo sapiens_hsa050120.69779548
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69332555
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68738504
98African trypanosomiasis_Homo sapiens_hsa051430.66527114
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65871200
100Ovarian steroidogenesis_Homo sapiens_hsa049130.65787574
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65309147
102Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65250765
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64023048
104Pancreatic cancer_Homo sapiens_hsa052120.63804879
105Vitamin digestion and absorption_Homo sapiens_hsa049770.63804229
106Proteasome_Homo sapiens_hsa030500.63125695
107Herpes simplex infection_Homo sapiens_hsa051680.63119016
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62193722
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62000850
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61612329
111Peroxisome_Homo sapiens_hsa041460.61584819
112Alcoholism_Homo sapiens_hsa050340.60774261
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59828880
114Fatty acid metabolism_Homo sapiens_hsa012120.58362867
115p53 signaling pathway_Homo sapiens_hsa041150.57621468
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57552179
117Pertussis_Homo sapiens_hsa051330.57162228
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56826076
119RNA degradation_Homo sapiens_hsa030180.56422509
120Phagosome_Homo sapiens_hsa041450.56333424
121Folate biosynthesis_Homo sapiens_hsa007900.55986865
122Histidine metabolism_Homo sapiens_hsa003400.53966997
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.53453299
124Non-small cell lung cancer_Homo sapiens_hsa052230.50977950
125Phenylalanine metabolism_Homo sapiens_hsa003600.50765252
126Viral carcinogenesis_Homo sapiens_hsa052030.49713593
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.47523910
128Chronic myeloid leukemia_Homo sapiens_hsa052200.47515029
129Mineral absorption_Homo sapiens_hsa049780.46937081
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46443005
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45771885
132Calcium signaling pathway_Homo sapiens_hsa040200.45501288
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.45427774
134Epstein-Barr virus infection_Homo sapiens_hsa051690.44242081
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44207439
136beta-Alanine metabolism_Homo sapiens_hsa004100.43843490
137Collecting duct acid secretion_Homo sapiens_hsa049660.43001467
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42315214
139Axon guidance_Homo sapiens_hsa043600.42015216
140Legionellosis_Homo sapiens_hsa051340.41814589
141Tyrosine metabolism_Homo sapiens_hsa003500.41727860
142ABC transporters_Homo sapiens_hsa020100.40786275
143Apoptosis_Homo sapiens_hsa042100.40407660
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40005122
145Olfactory transduction_Homo sapiens_hsa047400.38979796
146Spliceosome_Homo sapiens_hsa030400.37982063
147Wnt signaling pathway_Homo sapiens_hsa043100.36886144
148Glutamatergic synapse_Homo sapiens_hsa047240.36699261
149Chemokine signaling pathway_Homo sapiens_hsa040620.35454266
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35287879
151Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35274941
152Tuberculosis_Homo sapiens_hsa051520.34520189
153Salmonella infection_Homo sapiens_hsa051320.33716542
154B cell receptor signaling pathway_Homo sapiens_hsa046620.32450728
155Chemical carcinogenesis_Homo sapiens_hsa052040.30473165
156Endocytosis_Homo sapiens_hsa041440.26956722
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24873277
158Arginine and proline metabolism_Homo sapiens_hsa003300.23101618

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