HYAL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.31141507
2hemidesmosome assembly (GO:0031581)7.44574133
3negative regulation of cell fate specification (GO:0009996)6.32992649
4positive regulation of gastrulation (GO:2000543)6.29995547
5negative regulation of cell fate commitment (GO:0010454)6.14713027
6negative regulation of axon extension involved in axon guidance (GO:0048843)6.09274530
7regulation of cardioblast differentiation (GO:0051890)5.98788152
8cell wall macromolecule metabolic process (GO:0044036)5.57285060
9cell wall macromolecule catabolic process (GO:0016998)5.57285060
10cell proliferation in forebrain (GO:0021846)5.55504977
11regulation of cell-cell adhesion mediated by cadherin (GO:2000047)5.54651598
12sperm motility (GO:0030317)5.14883148
13keratinocyte development (GO:0003334)4.94833935
14multicellular organism reproduction (GO:0032504)4.94248482
15negative regulation of axon guidance (GO:1902668)4.93132123
16positive regulation of cardiac muscle cell differentiation (GO:2000727)4.89311373
17fusion of sperm to egg plasma membrane (GO:0007342)4.77211133
18cilium or flagellum-dependent cell motility (GO:0001539)4.72269046
19axonemal dynein complex assembly (GO:0070286)4.70025409
20cell fate commitment involved in formation of primary germ layer (GO:0060795)4.67040307
21positive regulation of catenin import into nucleus (GO:0035413)4.48545956
22fucose catabolic process (GO:0019317)4.42104740
23L-fucose metabolic process (GO:0042354)4.42104740
24L-fucose catabolic process (GO:0042355)4.42104740
25reproduction (GO:0000003)4.25915237
26motile cilium assembly (GO:0044458)4.14372604
27behavioral response to nicotine (GO:0035095)4.09127584
28DNA deamination (GO:0045006)4.04832543
29regulation of axon extension involved in axon guidance (GO:0048841)4.04778304
30positive regulation of cell fate commitment (GO:0010455)4.03795650
31sperm-egg recognition (GO:0035036)3.88539735
32fibrinolysis (GO:0042730)3.85781591
33acrosome reaction (GO:0007340)3.80335052
34neuron remodeling (GO:0016322)3.77584367
35spermatid development (GO:0007286)3.72268612
36response to pheromone (GO:0019236)3.71146385
37amino-acid betaine metabolic process (GO:0006577)3.67912152
38viral transcription (GO:0019083)3.67251809
39keratinocyte proliferation (GO:0043616)3.64109848
40pyrimidine nucleobase catabolic process (GO:0006208)3.62924639
41regulation of bile acid biosynthetic process (GO:0070857)3.61694371
42epithelial cilium movement (GO:0003351)3.61160341
43protein K11-linked deubiquitination (GO:0035871)3.55230480
44positive regulation of cellular amide metabolic process (GO:0034250)3.55034613
45regulation of axon guidance (GO:1902667)3.53685714
46cell-cell recognition (GO:0009988)3.53290008
47plasma membrane fusion (GO:0045026)3.52712263
48preassembly of GPI anchor in ER membrane (GO:0016254)3.52423188
49arginine catabolic process (GO:0006527)3.51199761
50acrosome assembly (GO:0001675)3.50029913
51male meiosis I (GO:0007141)3.49173407
52carnitine metabolic process (GO:0009437)3.47895053
53lateral sprouting from an epithelium (GO:0060601)3.46171478
54ubiquinone biosynthetic process (GO:0006744)3.42349266
55ribosomal small subunit biogenesis (GO:0042274)3.41832191
56translational termination (GO:0006415)3.41672325
57keratinocyte differentiation (GO:0030216)3.37912168
58synapsis (GO:0007129)3.36597054
59piRNA metabolic process (GO:0034587)3.35662817
60positive regulation of odontogenesis (GO:0042482)3.34736381
61regulation of cell fate specification (GO:0042659)3.33640285
62cilium movement (GO:0003341)3.31542446
63negative regulation of Ras GTPase activity (GO:0034261)3.27876963
64organic cation transport (GO:0015695)3.27490910
65photoreceptor cell maintenance (GO:0045494)3.26580531
66ubiquinone metabolic process (GO:0006743)3.25603278
67axoneme assembly (GO:0035082)3.24875611
68regulation of cilium movement (GO:0003352)3.24732924
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.23180731
70glycerophospholipid catabolic process (GO:0046475)3.22603895
71neural tube formation (GO:0001841)3.21775279
72protein polyglutamylation (GO:0018095)3.21687370
73regulation of collateral sprouting (GO:0048670)3.19863187
74respiratory chain complex IV assembly (GO:0008535)3.18884251
75DNA methylation involved in gamete generation (GO:0043046)3.17778964
76negative regulation of telomere maintenance (GO:0032205)3.17536002
77axis elongation (GO:0003401)3.16163666
78negative regulation of axon extension (GO:0030517)3.15617897
79spinal cord association neuron differentiation (GO:0021527)3.13111225
80water-soluble vitamin biosynthetic process (GO:0042364)3.12894061
81platelet dense granule organization (GO:0060155)3.11931296
82protein-cofactor linkage (GO:0018065)3.11115615
83resolution of meiotic recombination intermediates (GO:0000712)3.10865902
84binding of sperm to zona pellucida (GO:0007339)3.10555673
85type B pancreatic cell proliferation (GO:0044342)3.07442102
86nucleobase catabolic process (GO:0046113)3.06721705
87mitochondrial respiratory chain complex I assembly (GO:0032981)3.05533665
88NADH dehydrogenase complex assembly (GO:0010257)3.05533665
89mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.05533665
90protein complex biogenesis (GO:0070271)3.04469366
91cellular ketone body metabolic process (GO:0046950)3.04150478
92detection of light stimulus involved in sensory perception (GO:0050962)3.03046520
93detection of light stimulus involved in visual perception (GO:0050908)3.03046520
94establishment of protein localization to Golgi (GO:0072600)3.01861833
95detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.01591834
96sympathetic nervous system development (GO:0048485)3.01391420
97ethanol oxidation (GO:0006069)2.99655688
98keratinization (GO:0031424)2.98137232
99hair cycle (GO:0042633)2.97619888
100molting cycle (GO:0042303)2.97619888
101negative regulation of chemotaxis (GO:0050922)2.97325286
102establishment of skin barrier (GO:0061436)2.96727344
103negative regulation of cytosolic calcium ion concentration (GO:0051481)2.94952343
104dorsal/ventral neural tube patterning (GO:0021904)2.94942706
105regulation of cardiac muscle cell differentiation (GO:2000725)2.92147669
106regulation of cell fate commitment (GO:0010453)2.91483044
107interferon-gamma secretion (GO:0072643)2.90777872
108male meiosis (GO:0007140)2.89280705
109cell surface receptor signaling pathway involved in heart development (GO:0061311)2.88525894
110negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.88283182
111regulation of action potential (GO:0098900)2.87252191
112positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.86976277
113protein targeting to Golgi (GO:0000042)2.86894710
114ketone body metabolic process (GO:1902224)2.86156283
115regulation of mesoderm development (GO:2000380)2.84636555
116positive regulation of embryonic development (GO:0040019)2.82787392
117mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.82568145
118retinal cone cell development (GO:0046549)2.80419700
119mammary gland development (GO:0030879)2.80406113
120mitochondrial respiratory chain complex assembly (GO:0033108)2.80084845
121peptidyl-histidine modification (GO:0018202)2.78645412
122quinone biosynthetic process (GO:1901663)2.78241915
123nonmotile primary cilium assembly (GO:0035058)2.77235924
124indolalkylamine metabolic process (GO:0006586)2.76759424
125cytochrome complex assembly (GO:0017004)2.75771804
126replication fork processing (GO:0031297)2.74485480
127epidermis development (GO:0008544)2.71196163
128GPI anchor metabolic process (GO:0006505)2.71036788
129positive regulation of mitochondrial fission (GO:0090141)2.70911944
130regulation of meiosis I (GO:0060631)2.70207425
131reciprocal DNA recombination (GO:0035825)2.69676904
132reciprocal meiotic recombination (GO:0007131)2.69676904
133regulation of water loss via skin (GO:0033561)2.69636062
134regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.69342642
135amine catabolic process (GO:0009310)2.68429852
136cellular biogenic amine catabolic process (GO:0042402)2.68429852
137arginine metabolic process (GO:0006525)2.66854544
138primary alcohol catabolic process (GO:0034310)2.65964571
139prepulse inhibition (GO:0060134)2.64568617
140neuronal action potential (GO:0019228)2.63569046
141indole-containing compound catabolic process (GO:0042436)2.63515000
142indolalkylamine catabolic process (GO:0046218)2.63515000
143tryptophan catabolic process (GO:0006569)2.63515000
144neuronal action potential propagation (GO:0019227)2.63171960
145meiosis I (GO:0007127)2.61783223
146cornea development in camera-type eye (GO:0061303)2.61777427
147positive regulation of monocyte chemotaxis (GO:0090026)2.61667520
148L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.60883271
149dendritic spine organization (GO:0097061)2.60259618
150SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.60225225
151single fertilization (GO:0007338)2.60016818
152cell-substrate junction assembly (GO:0007044)2.59434861
153transepithelial transport (GO:0070633)2.58814786
154regulation of catenin import into nucleus (GO:0035412)2.58646849
155translational elongation (GO:0006414)2.58625357
156cotranslational protein targeting to membrane (GO:0006613)2.57282697
157cranial nerve development (GO:0021545)2.57270472
158regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)2.57156771
159cilium morphogenesis (GO:0060271)2.57025913
160protein targeting to ER (GO:0045047)2.56958422
161erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.55581141
162L-phenylalanine catabolic process (GO:0006559)2.55581141
163kynurenine metabolic process (GO:0070189)2.54418233
164regulation of microtubule-based movement (GO:0060632)2.54194274
165polyol catabolic process (GO:0046174)2.53846129
166protein K6-linked ubiquitination (GO:0085020)2.53803255
167negative regulation of amino acid transport (GO:0051956)2.53567485
168positive regulation of hormone metabolic process (GO:0032352)2.53170039
169myoblast fusion (GO:0007520)2.52959331
170S-adenosylmethionine metabolic process (GO:0046500)2.52228079
171cellular protein complex disassembly (GO:0043624)2.51482031
172single strand break repair (GO:0000012)2.51269496
173proton transport (GO:0015992)2.51183338
174negative regulation of heart rate (GO:0010459)2.50388576
175inositol phosphate catabolic process (GO:0071545)2.49754397
176negative regulation of wound healing (GO:0061045)2.49010433
177hydrogen transport (GO:0006818)2.47949737
178neuron maturation (GO:0042551)2.47461167
179electron transport chain (GO:0022900)2.46553282
180microtubule bundle formation (GO:0001578)2.46264237
181establishment of protein localization to endoplasmic reticulum (GO:0072599)2.45821131
182tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.45219893
183RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.45219893
184positive regulation of meiosis (GO:0045836)2.45022957
185somite development (GO:0061053)2.44911025
186transmission of nerve impulse (GO:0019226)2.44770699
187synaptic transmission, cholinergic (GO:0007271)2.43916528
188behavioral response to ethanol (GO:0048149)2.43730340
189regulation of glucokinase activity (GO:0033131)2.43430583
190regulation of hexokinase activity (GO:1903299)2.43430583
191response to dietary excess (GO:0002021)2.42857367
192respiratory electron transport chain (GO:0022904)2.42673752
193protein localization to cilium (GO:0061512)2.42642282

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.44272792
2ZNF274_21170338_ChIP-Seq_K562_Hela3.81368279
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.33020266
4IGF1R_20145208_ChIP-Seq_DFB_Human3.28967358
5EZH2_22144423_ChIP-Seq_EOC_Human2.79459580
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.67499559
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41849301
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38095303
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.28204982
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.26222852
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22769859
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08420937
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08281112
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07583388
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99549926
16* VDR_22108803_ChIP-Seq_LS180_Human1.91180232
17P300_19829295_ChIP-Seq_ESCs_Human1.84092459
18EWS_26573619_Chip-Seq_HEK293_Human1.83239001
19NOTCH1_21737748_ChIP-Seq_TLL_Human1.79583895
20IRF1_19129219_ChIP-ChIP_H3396_Human1.79226043
21TP53_22573176_ChIP-Seq_HFKS_Human1.78034875
22FUS_26573619_Chip-Seq_HEK293_Human1.74325015
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.73912720
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.69628419
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68194466
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67839614
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65472828
28ER_23166858_ChIP-Seq_MCF-7_Human1.64839107
29AR_21572438_ChIP-Seq_LNCaP_Human1.64197610
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62814576
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.62730657
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62353070
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61055378
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59458128
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58757210
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.58190964
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58147433
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.56921922
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56174974
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54769442
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.51614110
42REST_21632747_ChIP-Seq_MESCs_Mouse1.45875434
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.43186422
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43019361
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.41982233
46SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41188148
47STAT3_23295773_ChIP-Seq_U87_Human1.39841821
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39372238
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39315486
50NANOG_19829295_ChIP-Seq_ESCs_Human1.37647191
51SOX2_19829295_ChIP-Seq_ESCs_Human1.37647191
52* TCF4_23295773_ChIP-Seq_U87_Human1.36572510
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36453921
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.36052306
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35272366
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35205908
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34072526
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33853720
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33522299
60TAL1_26923725_Chip-Seq_HPCs_Mouse1.32384560
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31716714
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30709357
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30545890
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30469428
65TCF4_18268006_ChIP-ChIP_LS174T_Human1.28818614
66AR_25329375_ChIP-Seq_VCAP_Human1.28728615
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27926185
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.27828610
69* GATA3_21878914_ChIP-Seq_MCF-7_Human1.27711167
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27026106
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26962625
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26258451
73FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26253076
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23842798
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.23044207
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23044207
77HOXB7_26014856_ChIP-Seq_BT474_Human1.22977693
78MYC_18940864_ChIP-ChIP_HL60_Human1.22844613
79TCF4_22108803_ChIP-Seq_LS180_Human1.22610013
80NCOR_22424771_ChIP-Seq_293T_Human1.22582407
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21987183
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21987183
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21702742
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21226953
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20795742
86MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18961130
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.18009184
88TAF15_26573619_Chip-Seq_HEK293_Human1.17868905
89RUNX2_22187159_ChIP-Seq_PCA_Human1.17321900
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17065082
91RNF2_27304074_Chip-Seq_ESCs_Mouse1.16655246
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.16594489
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16283588
94JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15852215
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15457003
96KDM2B_26808549_Chip-Seq_REH_Human1.15305476
97ELK1_19687146_ChIP-ChIP_HELA_Human1.14990715
98AR_20517297_ChIP-Seq_VCAP_Human1.14858563
99REST_18959480_ChIP-ChIP_MESCs_Mouse1.14657597
100BCAT_22108803_ChIP-Seq_LS180_Human1.14473039
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13741675
102VDR_23849224_ChIP-Seq_CD4+_Human1.13673792
103CRX_20693478_ChIP-Seq_RETINA_Mouse1.11828837
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11781949
105BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11614398
106TP53_18474530_ChIP-ChIP_U2OS_Human1.11149675
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10678786
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09674243
109* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09512606
110ETS1_20019798_ChIP-Seq_JURKAT_Human1.09360181
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09194074
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08569881
113CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08151132
114SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07675013
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.07067150
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.06100277
117PIAS1_25552417_ChIP-Seq_VCAP_Human1.05648041
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05452559
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05300113
120P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05296887
121CMYC_18555785_Chip-Seq_ESCs_Mouse1.04646363
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04452936
123JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04419071
124ESR1_21235772_ChIP-Seq_MCF-7_Human1.04144525
125ERA_21632823_ChIP-Seq_H3396_Human1.03402333
126CJUN_26792858_Chip-Seq_BT549_Human1.03378805
127P53_22387025_ChIP-Seq_ESCs_Mouse1.03234094
128FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03192241
129HTT_18923047_ChIP-ChIP_STHdh_Human1.02820895
130FOXH1_21741376_ChIP-Seq_EPCs_Human1.02381718
131JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01607600
132PRDM14_20953172_ChIP-Seq_ESCs_Human1.01603727
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01410331
134TP63_23658742_ChIP-Seq_EP156T_Human1.00856971
135MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00573767
136AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00308637
137SMAD3_21741376_ChIP-Seq_EPCs_Human1.00085875
138STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99131426
139OCT4_18555785_Chip-Seq_ESCs_Mouse0.98926901
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.98178593
141MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97510701
142AHR_22903824_ChIP-Seq_MCF-7_Human0.97105845
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95339005
144RING1B_27294783_Chip-Seq_ESCs_Mouse0.94768564
145PU1_27457419_Chip-Seq_LIVER_Mouse0.94336072
146RXR_22158963_ChIP-Seq_LIVER_Mouse0.94179957
147GBX2_23144817_ChIP-Seq_PC3_Human0.94033680
148OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93984935
149EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93815857
150EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93526198
151RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93526198
152CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92853547
153SMAD4_21799915_ChIP-Seq_A2780_Human0.92845594
154P300_18555785_Chip-Seq_ESCs_Mouse0.92483168
155LXR_22158963_ChIP-Seq_LIVER_Mouse0.91378921
156TP53_20018659_ChIP-ChIP_R1E_Mouse0.90938446
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90629437
158CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90416065
159KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90320441
160TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89945331
161RUNX1_27457419_Chip-Seq_LIVER_Mouse0.89282736
162IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89142078
163CBP_20019798_ChIP-Seq_JUKART_Human0.89142078
164SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89067487
165SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89008791
166SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89008791
167RNF2_27304074_Chip-Seq_NSC_Mouse0.88779299
168SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88735765

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat7.82776292
2MP0002796_impaired_skin_barrier5.00370993
3MP0005410_abnormal_fertilization4.14238150
4MP0000383_abnormal_hair_follicle3.80102746
5MP0002060_abnormal_skin_morphology3.74378935
6MP0001346_abnormal_lacrimal_gland3.69099178
7MP0000579_abnormal_nail_morphology3.59055050
8MP0005275_abnormal_skin_tensile3.41911637
9MP0008877_abnormal_DNA_methylation3.41457390
10MP0000647_abnormal_sebaceous_gland3.32729323
11MP0003787_abnormal_imprinting3.17670488
12MP0003646_muscle_fatigue2.90577411
13MP0010678_abnormal_skin_adnexa2.89706423
14MP0004381_abnormal_hair_follicle2.76781273
15MP0000467_abnormal_esophagus_morphology2.62329979
16MP0000566_synostosis2.58076913
17MP0002098_abnormal_vibrissa_morphology2.48608529
18MP0005551_abnormal_eye_electrophysiolog2.44067858
19MP0003880_abnormal_central_pattern2.35407158
20MP0002009_preneoplasia2.34488170
21MP0001968_abnormal_touch/_nociception2.34251410
22MP0003941_abnormal_skin_development2.32676161
23MP0010771_integument_phenotype2.30430103
24MP0005501_abnormal_skin_physiology2.30248766
25MP0001216_abnormal_epidermal_layer2.26025408
26MP0005360_urolithiasis2.22940044
27MP0002837_dystrophic_cardiac_calcinosis2.20855067
28MP0009379_abnormal_foot_pigmentation2.16188021
29MP0005645_abnormal_hypothalamus_physiol2.15820434
30MP0004147_increased_porphyrin_level2.11916368
31MP0008875_abnormal_xenobiotic_pharmacok2.02403137
32MP0000372_irregular_coat_pigmentation1.98009674
33MP0002277_abnormal_respiratory_mucosa1.95096950
34MP0005253_abnormal_eye_physiology1.92689841
35MP0002876_abnormal_thyroid_physiology1.90647839
36MP0002736_abnormal_nociception_after1.88558234
37MP0009384_cardiac_valve_regurgitation1.87441645
38MP0009745_abnormal_behavioral_response1.82193794
39MP0004145_abnormal_muscle_electrophysio1.80614543
40MP0005647_abnormal_sex_gland1.76598011
41MP0001529_abnormal_vocalization1.73716300
42MP0004885_abnormal_endolymph1.73644287
43MP0005379_endocrine/exocrine_gland_phen1.73225987
44MP0000762_abnormal_tongue_morphology1.73008453
45MP0004272_abnormal_basement_membrane1.71302253
46MP0001485_abnormal_pinna_reflex1.70889171
47MP0000427_abnormal_hair_cycle1.69928447
48MP0008057_abnormal_DNA_replication1.67250844
49MP0002272_abnormal_nervous_system1.64599268
50MP0010234_abnormal_vibrissa_follicle1.61632290
51MP0008872_abnormal_physiological_respon1.61583891
52MP0002163_abnormal_gland_morphology1.61049898
53MP0003453_abnormal_keratinocyte_physiol1.60342557
54MP0005085_abnormal_gallbladder_physiolo1.59718640
55MP0001986_abnormal_taste_sensitivity1.57478939
56MP0001340_abnormal_eyelid_morphology1.56277709
57MP0002102_abnormal_ear_morphology1.53076836
58MP0000377_abnormal_hair_follicle1.49922278
59MP0002282_abnormal_trachea_morphology1.49178878
60MP0003121_genomic_imprinting1.45475876
61MP0006292_abnormal_olfactory_placode1.43729258
62MP0002653_abnormal_ependyma_morphology1.43089403
63MP0002249_abnormal_larynx_morphology1.40466758
64MP0008995_early_reproductive_senescence1.38218533
65MP0002909_abnormal_adrenal_gland1.38191019
66MP0004019_abnormal_vitamin_homeostasis1.36991582
67MP0001501_abnormal_sleep_pattern1.35695117
68MP0005167_abnormal_blood-brain_barrier1.35324426
69MP0000538_abnormal_urinary_bladder1.33423149
70MP0004133_heterotaxia1.32518531
71MP0003698_abnormal_male_reproductive1.32257719
72MP0005389_reproductive_system_phenotype1.31835486
73MP0001486_abnormal_startle_reflex1.31795412
74MP0002139_abnormal_hepatobiliary_system1.31678016
75MP0005646_abnormal_pituitary_gland1.29138194
76MP0003136_yellow_coat_color1.26840888
77MP0005084_abnormal_gallbladder_morpholo1.26544500
78MP0002160_abnormal_reproductive_system1.25532735
79MP0002572_abnormal_emotion/affect_behav1.22076522
80MP0004947_skin_inflammation1.18940538
81MP0005423_abnormal_somatic_nervous1.18841679
82MP0010030_abnormal_orbit_morphology1.17772978
83MP0001970_abnormal_pain_threshold1.15565114
84MP0005075_abnormal_melanosome_morpholog1.15294333
85MP0003252_abnormal_bile_duct1.15050706
86MP0005409_darkened_coat_color1.14717783
87MP0003635_abnormal_synaptic_transmissio1.13882558
88MP0001905_abnormal_dopamine_level1.13227548
89MP0001188_hyperpigmentation1.12713975
90MP0002733_abnormal_thermal_nociception1.12668274
91MP0006036_abnormal_mitochondrial_physio1.12326456
92MP0000631_abnormal_neuroendocrine_gland1.11891889
93MP0002735_abnormal_chemical_nociception1.11765279
94MP0008789_abnormal_olfactory_epithelium1.11346926
95MP0003122_maternal_imprinting1.10311539
96MP0002928_abnormal_bile_duct1.10149421
97MP0008058_abnormal_DNA_repair1.10048853
98MP0002064_seizures1.09674907
99MP0001919_abnormal_reproductive_system1.09574612
100MP0002938_white_spotting1.06052462
101MP0003705_abnormal_hypodermis_morpholog1.05402039
102MP0003878_abnormal_ear_physiology1.05045938
103MP0005377_hearing/vestibular/ear_phenot1.05045938
104MP0002063_abnormal_learning/memory/cond1.04717632
105MP0006035_abnormal_mitochondrial_morpho1.04329824
106MP0004043_abnormal_pH_regulation1.04085742
107MP0002557_abnormal_social/conspecific_i1.02153659
108MP0000778_abnormal_nervous_system1.02074973
109MP0004924_abnormal_behavior1.01847752
110MP0005386_behavior/neurological_phenoty1.01847752
111MP0005195_abnormal_posterior_eye1.00938788
112MP0002067_abnormal_sensory_capabilities1.00856130
113MP0001191_abnormal_skin_condition0.99252175
114MP0002229_neurodegeneration0.98946323
115MP0003195_calcinosis0.98352778
116MP0003011_delayed_dark_adaptation0.97582160
117MP0002822_catalepsy0.97562242
118MP0002752_abnormal_somatic_nervous0.96750878
119MP0009053_abnormal_anal_canal0.96468746
120MP0009931_abnormal_skin_appearance0.96201616
121MP0003385_abnormal_body_wall0.95499750
122MP0002734_abnormal_mechanical_nocicepti0.94501631
123MP0009250_abnormal_appendicular_skeleto0.93963363
124MP0001929_abnormal_gametogenesis0.93328302
125MP0003890_abnormal_embryonic-extraembry0.92623427
126MP0002095_abnormal_skin_pigmentation0.92613326
127MP0003718_maternal_effect0.92611674
128MP0002184_abnormal_innervation0.92605119
129MP0002234_abnormal_pharynx_morphology0.91872099
130MP0003806_abnormal_nucleotide_metabolis0.91856572
131MP0001765_abnormal_ion_homeostasis0.89397421
132MP0004270_analgesia0.87199744
133MP0003186_abnormal_redox_activity0.86845059
134MP0002751_abnormal_autonomic_nervous0.86705594
135MP0003828_pulmonary_edema0.86660769
136MP0003786_premature_aging0.85242716
137MP0000653_abnormal_sex_gland0.84427264
138MP0008775_abnormal_heart_ventricle0.83804075
139MP0005365_abnormal_bile_salt0.83329184
140MP0010329_abnormal_lipoprotein_level0.81143954
141MP0004215_abnormal_myocardial_fiber0.80901369
142MP0000613_abnormal_salivary_gland0.80885615
143MP0000367_abnormal_coat/_hair0.78975722
144MP0003937_abnormal_limbs/digits/tail_de0.78253952
145MP0002166_altered_tumor_susceptibility0.76988158
146MP0002638_abnormal_pupillary_reflex0.75723474
147MP0000627_abnormal_mammary_gland0.75269774
148MP0002210_abnormal_sex_determination0.69932885
149MP0001984_abnormal_olfaction0.69171901
150MP0006276_abnormal_autonomic_nervous0.66824116
151MP0001851_eye_inflammation0.66030314
152MP0009764_decreased_sensitivity_to0.65570152
153MP0005023_abnormal_wound_healing0.64414069
154MP0005165_increased_susceptibility_to0.63430501
155MP0005623_abnormal_meninges_morphology0.63317111
156MP0003936_abnormal_reproductive_system0.61964127
157MP0002161_abnormal_fertility/fecundity0.61627629
158MP0003566_abnormal_cell_adhesion0.61285695
159MP0003638_abnormal_response/metabolism_0.59932055
160MP0002177_abnormal_outer_ear0.59783146
161MP0008007_abnormal_cellular_replicative0.58439689
162MP0002108_abnormal_muscle_morphology0.57713135
163MP0003938_abnormal_ear_development0.57436164
164MP0000920_abnormal_myelination0.56576178
165MP0004858_abnormal_nervous_system0.56041000
166MP0001756_abnormal_urination0.55347899
167MP0006072_abnormal_retinal_apoptosis0.55088822
168MP0004782_abnormal_surfactant_physiolog0.53162753
169MP0010352_gastrointestinal_tract_polyps0.52665512
170MP0005388_respiratory_system_phenotype0.50923781
171MP0002133_abnormal_respiratory_system0.50923781
172MP0004142_abnormal_muscle_tone0.49009358
173MP0002896_abnormal_bone_mineralization0.47047737
174MP0009046_muscle_twitch0.46952284
175MP0005083_abnormal_biliary_tract0.45417785
176MP0001243_abnormal_dermal_layer0.45386468
177MP0004742_abnormal_vestibular_system0.45382177
178MP0005248_abnormal_Harderian_gland0.43680255
179MP0002118_abnormal_lipid_homeostasis0.43412370
180MP0002006_tumorigenesis0.43337738

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)7.37691897
2Absent/shortened dynein arms (HP:0200106)7.37691897
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.78209882
4Onycholysis (HP:0001806)5.17374346
5Abnormal respiratory motile cilium physiology (HP:0012261)4.74849252
6Abnormal respiratory motile cilium morphology (HP:0005938)4.73121631
7Abnormal respiratory epithelium morphology (HP:0012253)4.73121631
8Plantar hyperkeratosis (HP:0007556)4.72722598
9Abnormal ciliary motility (HP:0012262)4.48543142
10Abnormal hemoglobin (HP:0011902)4.42820508
11Fragile nails (HP:0001808)4.40098483
12Milia (HP:0001056)4.40049976
13Hypotrichosis (HP:0001006)3.88976606
14Aplasia cutis congenita (HP:0001057)3.84068006
15Abnormality of midbrain morphology (HP:0002418)3.75305365
16Molar tooth sign on MRI (HP:0002419)3.75305365
17Nephronophthisis (HP:0000090)3.75231759
18Parakeratosis (HP:0001036)3.68137757
19Pancreatic cysts (HP:0001737)3.62379094
20Woolly hair (HP:0002224)3.52985252
21Distal lower limb muscle weakness (HP:0009053)3.41568722
22Congenital stationary night blindness (HP:0007642)3.37421691
23Right ventricular cardiomyopathy (HP:0011663)3.36409509
24Hyporeflexia of lower limbs (HP:0002600)3.35616617
25True hermaphroditism (HP:0010459)3.28356580
26Pancreatic fibrosis (HP:0100732)3.27900025
27Lip pit (HP:0100267)3.27157849
28Medial flaring of the eyebrow (HP:0010747)3.22541484
29Chronic bronchitis (HP:0004469)3.13635428
30Abnormality of the renal medulla (HP:0100957)3.08172386
31Atrophic scars (HP:0001075)3.04811154
32Severe Myopia (HP:0011003)3.01134568
33Acute necrotizing encephalopathy (HP:0006965)2.98923503
34Hypodontia (HP:0000668)2.94011226
35Increased CSF lactate (HP:0002490)2.90172691
36Abnormality of the 2nd finger (HP:0004100)2.85969202
37Rhinitis (HP:0012384)2.83195410
38Mitochondrial inheritance (HP:0001427)2.80567507
39Abnormality of the nasal septum (HP:0000419)2.76149513
40Down-sloping shoulders (HP:0200021)2.75558978
41Xanthomatosis (HP:0000991)2.72472063
42Type II lissencephaly (HP:0007260)2.70446356
43Abnormal rod and cone electroretinograms (HP:0008323)2.70172621
44Palmoplantar hyperkeratosis (HP:0000972)2.70139701
45Hepatocellular necrosis (HP:0001404)2.68488450
46Bilateral microphthalmos (HP:0007633)2.67344648
47Abnormality of cells of the erythroid lineage (HP:0012130)2.66674777
48Progressive macrocephaly (HP:0004481)2.65426498
49Acute encephalopathy (HP:0006846)2.64469668
50Gait imbalance (HP:0002141)2.64160254
51Inability to walk (HP:0002540)2.62537808
52Progressive inability to walk (HP:0002505)2.60183093
53Abnormality of the renal cortex (HP:0011035)2.58455951
54Acanthosis nigricans (HP:0000956)2.55873597
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.54815927
56White forelock (HP:0002211)2.54663557
57Nephrogenic diabetes insipidus (HP:0009806)2.52977796
58Congenital primary aphakia (HP:0007707)2.52867792
59Alopecia of scalp (HP:0002293)2.52537217
60Abnormal mitochondria in muscle tissue (HP:0008316)2.51617285
61Hepatic necrosis (HP:0002605)2.50825387
62Chronic hepatic failure (HP:0100626)2.50273946
63Nasal polyposis (HP:0100582)2.48488721
64Nail dystrophy (HP:0008404)2.48365213
65Genital tract atresia (HP:0001827)2.47747635
66Palmar hyperkeratosis (HP:0010765)2.47205491
67Hypoparathyroidism (HP:0000829)2.46194749
68Hyperventilation (HP:0002883)2.44178570
69Vaginal atresia (HP:0000148)2.43486624
70Neonatal respiratory distress (HP:0002643)2.42966595
71Hypoplasia of the fovea (HP:0007750)2.40927051
72Aplasia/Hypoplasia of the fovea (HP:0008060)2.40927051
73Prolonged partial thromboplastin time (HP:0003645)2.39271905
74Muscle stiffness (HP:0003552)2.38343781
753-Methylglutaconic aciduria (HP:0003535)2.37609105
76Abnormality of the labia minora (HP:0012880)2.37360110
77Sparse lateral eyebrow (HP:0005338)2.36575742
78Deep venous thrombosis (HP:0002625)2.36174254
79Ulnar claw (HP:0001178)2.35078017
80Lissencephaly (HP:0001339)2.35055625
81Abolished electroretinogram (ERG) (HP:0000550)2.35007289
82Hypochromic anemia (HP:0001931)2.33585703
83Lipid accumulation in hepatocytes (HP:0006561)2.31865727
84Reticulocytopenia (HP:0001896)2.31851344
85Attenuation of retinal blood vessels (HP:0007843)2.30963198
86Abnormality of nail color (HP:0100643)2.27236767
87Hypoalphalipoproteinemia (HP:0003233)2.26970011
88Hypoplasia of dental enamel (HP:0006297)2.26835193
89Sclerocornea (HP:0000647)2.24245712
90Increased hepatocellular lipid droplets (HP:0006565)2.22890556
91Abnormal number of erythroid precursors (HP:0012131)2.22642653
92Increased serum lactate (HP:0002151)2.22021952
93Calf muscle hypertrophy (HP:0008981)2.21846130
94Infertility (HP:0000789)2.21452922
95Optic disc pallor (HP:0000543)2.21217094
96Abnormal blistering of the skin (HP:0008066)2.19658795
97Abnormal drinking behavior (HP:0030082)2.19404781
98Polydipsia (HP:0001959)2.19404781
99Pachygyria (HP:0001302)2.17400823
100Hyperglycinemia (HP:0002154)2.16424159
101Pendular nystagmus (HP:0012043)2.16116688
102Congenital, generalized hypertrichosis (HP:0004540)2.15967724
103Ridged nail (HP:0001807)2.15388472
104Thick nail (HP:0001805)2.14145869
105Recurrent sinusitis (HP:0011108)2.11471790
106Patchy hypopigmentation of hair (HP:0011365)2.11398129
107Abnormality of the axillary hair (HP:0100134)2.11168004
108Abnormality of secondary sexual hair (HP:0009888)2.11168004
109Abnormality of the fovea (HP:0000493)2.06908212
110Cystic liver disease (HP:0006706)2.06655091
111Concave nail (HP:0001598)2.06577611
112Morphological abnormality of the middle ear (HP:0008609)2.06524499
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06172075
114Abnormality of alanine metabolism (HP:0010916)2.06172075
115Hyperalaninemia (HP:0003348)2.06172075
116Hypothermia (HP:0002045)2.05101982
117Increased corneal curvature (HP:0100692)2.04880304
118Keratoconus (HP:0000563)2.04880304
119Bony spicule pigmentary retinopathy (HP:0007737)2.03878316
120Bronchiectasis (HP:0002110)2.03779435
121Aplasia/Hypoplasia of the spleen (HP:0010451)2.02909067
122Orchitis (HP:0100796)2.02817686
123Optic neuritis (HP:0100653)2.01907710
124Retrobulbar optic neuritis (HP:0100654)2.01907710
125Nemaline bodies (HP:0003798)2.01847901
126Delayed CNS myelination (HP:0002188)2.01824312
127Gangrene (HP:0100758)2.01389091
128Hypoproteinemia (HP:0003075)1.99813933
129Areflexia of lower limbs (HP:0002522)1.98419165
130Methylmalonic acidemia (HP:0002912)1.96723144
131Febrile seizures (HP:0002373)1.96136175
132Renal dysplasia (HP:0000110)1.96079649
133Male pseudohermaphroditism (HP:0000037)1.95711066
134Aplasia involving bones of the upper limbs (HP:0009823)1.95684333
135Aplasia of the phalanges of the hand (HP:0009802)1.95684333
136Aplasia involving bones of the extremities (HP:0009825)1.95684333
137Abnormality of the nasal mucosa (HP:0000433)1.94679544
138Methylmalonic aciduria (HP:0012120)1.94448058
139Difficulty running (HP:0009046)1.94010872
140Exercise-induced myalgia (HP:0003738)1.93748439
141Thyroid-stimulating hormone excess (HP:0002925)1.93377239
142Recurrent corneal erosions (HP:0000495)1.91896647
143Muscle hypertrophy of the lower extremities (HP:0008968)1.90654385
144Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89308627
145Focal motor seizures (HP:0011153)1.88423479
146Split foot (HP:0001839)1.87943441
147Oligodactyly (hands) (HP:0001180)1.87043467
148Hyperglycinuria (HP:0003108)1.86267936
149Abnormal biliary tract physiology (HP:0012439)1.86194403
150Bile duct proliferation (HP:0001408)1.86194403
151Agitation (HP:0000713)1.86083518
152Lactic acidosis (HP:0003128)1.85464922
153Retinitis pigmentosa (HP:0000510)1.85232654
154Distal lower limb amyotrophy (HP:0008944)1.84962836
155Intestinal atresia (HP:0011100)1.84806990
156Macrocytic anemia (HP:0001972)1.84177771
157Congenital hepatic fibrosis (HP:0002612)1.83137228
158Polyuria (HP:0000103)1.82721833
159Advanced eruption of teeth (HP:0006288)1.81171531
160Renal cortical cysts (HP:0000803)1.80988227
161Abnormality of the dental pulp (HP:0006479)1.79937286
162Cerebral edema (HP:0002181)1.78792008
163Large for gestational age (HP:0001520)1.77742471
164Anencephaly (HP:0002323)1.77156570
165Hypohidrosis (HP:0000966)1.77146799
166Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76787477
167Esophageal atresia (HP:0002032)1.76655542
168Drooling (HP:0002307)1.75981436
169Conical tooth (HP:0000698)1.75822281
170Gaze-evoked nystagmus (HP:0000640)1.75713078
171Pili torti (HP:0003777)1.75474459
172Retinal dysplasia (HP:0007973)1.75081986
173Venous insufficiency (HP:0005293)1.74141065
174Broad-based gait (HP:0002136)1.74009195
175Asplenia (HP:0001746)1.73925773
176Optic nerve hypoplasia (HP:0000609)1.73025349
177Corneal erosion (HP:0200020)1.72505609
178Aplasia/Hypoplasia of the tongue (HP:0010295)1.71920145
179Narrow forehead (HP:0000341)1.71435821
180Nasolacrimal duct obstruction (HP:0000579)1.70746407
181Abnormality of the renal collecting system (HP:0004742)1.70728643
182Postaxial foot polydactyly (HP:0001830)1.69972292
183Decreased central vision (HP:0007663)1.69490204
184Hyperlipoproteinemia (HP:0010980)1.67639503
185Progressive cerebellar ataxia (HP:0002073)1.64849862
186Pallor (HP:0000980)1.64046035
187Intrahepatic cholestasis (HP:0001406)1.60819991
188Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.60780310
189Fragile skin (HP:0001030)1.59933899
190Tubular atrophy (HP:0000092)1.59529807

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.11833151
2PDK36.11833151
3MAPKAPK35.07729911
4PDK24.77092586
5MST1R4.22225470
6EEF2K3.21948957
7PINK13.17959611
8ADRBK22.80882685
9WNK32.76852815
10MAP3K42.60697092
11FGFR22.35046903
12NUAK12.23406367
13ZAK2.22645073
14MAP4K22.17582840
15TRPM71.92665221
16CDK191.89404976
17ACVR1B1.89039314
18EIF2AK31.86755474
19FRK1.85831195
20PHKG11.84190412
21PHKG21.84190412
22RPS6KB21.84017498
23TYK21.83276359
24TRIM281.73924925
25PIK3CG1.73730069
26FER1.67128401
27DYRK21.60685493
28CASK1.54734747
29MAPKAPK51.52011033
30INSRR1.49808947
31NTRK21.48644699
32DYRK31.44543488
33TXK1.44414007
34MAPK151.42273978
35TAOK31.41159837
36BCR1.35200470
37TLK11.35064284
38BCKDK1.34087917
39PAK31.29530759
40MARK11.25634839
41MAPK121.25402072
42PTK61.23930104
43MAP3K11.13007052
44OBSCN1.11630280
45CAMKK21.11265160
46RIPK41.10170385
47STK161.07374077
48CSNK1G21.06611987
49PLK21.05681775
50TAOK11.05002556
51MET1.04805360
52CSNK1G11.00788371
53STK390.98936176
54BMPR1B0.95436149
55PRKCH0.94894783
56MST40.91160901
57CSNK1G30.90922667
58NTRK30.90623794
59DAPK20.90530378
60MKNK20.90225947
61ERBB30.88640854
62STK30.88500255
63SIK10.86926984
64EPHB20.86858911
65LRRK20.85948877
66ADRBK10.85413732
67EPHB10.84664626
68PRKCE0.84528029
69RIPK10.80893535
70DYRK1B0.80739390
71BLK0.80146383
72STK38L0.79634389
73MAPK70.77994102
74IRAK20.76875175
75SRPK10.75384651
76CSNK1A1L0.73470505
77TNK20.71853048
78PNCK0.71149763
79VRK10.70358364
80WNK40.70051097
81MAP2K70.68625549
82MAP3K120.68496895
83EIF2AK10.68079090
84MINK10.67555303
85SIK20.66997118
86IRAK30.66468499
87VRK20.65341359
88MUSK0.64096429
89PKN10.62870722
90TESK10.61532641
91PLK40.61299613
92EIF2AK20.60744442
93STK240.60335315
94TIE10.59680062
95TGFBR10.59292680
96MAP3K140.57908768
97MAP2K10.57901357
98OXSR10.56604659
99EPHA40.54187358
100PRKD10.52502317
101GRK10.52492321
102PRKCQ0.52100986
103TNIK0.52092677
104MAP3K30.52066471
105STK110.51473789
106PTK2B0.51302594
107PLK30.51214467
108SGK30.50674271
109MAP3K20.49539771
110TAOK20.48680246
111PRKCI0.48660126
112GRK70.46302089
113SGK2230.45803547
114SGK4940.45803547
115RPS6KA40.45309103
116FGFR40.45151701
117CSNK1A10.43914090
118PRKAA20.43402035
119MARK20.42197839
120PBK0.40239398
121PLK10.39658599
122LIMK10.39375174
123PRKAA10.39326214
124SYK0.38216588
125PIK3CA0.37482334
126IKBKB0.36881433
127CSNK1D0.36260353
128TTN0.35633240
129CDK30.35457642
130MAP2K40.35078022
131JAK20.34685600
132TSSK60.34637949
133ERBB40.34488255
134PRKG10.33830653
135AKT30.33655327
136SGK10.33244633
137TGFBR20.32780415
138CDK80.32106760
139SRC0.31992361
140PDK10.31256808
141CAMK2D0.30773710
142NEK60.30535221
143WNK10.30440163
144TEC0.29973018
145CAMK2A0.29449712
146CAMK10.29226079
147NTRK10.28842086
148SIK30.28810042
149PRKACG0.26874328
150MAP3K60.26744387
151PDGFRB0.26211090
152CDK50.25285051
153RPS6KA20.24449861
154CAMK1G0.22915751
155CDK90.22867853
156JAK10.22639058
157CLK10.20928351
158PRKCA0.20334201
159MAP2K60.18994336
160PRKACA0.18686324
161ITK0.18420359
162CSF1R0.17656567
163ERBB20.17113189
164PRKCG0.16906804
165MAPK130.16883020
166HCK0.16463995

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.05184496
2Oxidative phosphorylation_Homo sapiens_hsa001902.97716637
3Hedgehog signaling pathway_Homo sapiens_hsa043402.92319486
4Nitrogen metabolism_Homo sapiens_hsa009102.78563056
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.60244194
6Parkinsons disease_Homo sapiens_hsa050122.43975309
7Fatty acid elongation_Homo sapiens_hsa000622.42401781
8Fatty acid degradation_Homo sapiens_hsa000712.41080420
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.35653638
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18836610
11Complement and coagulation cascades_Homo sapiens_hsa046102.14304517
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09672288
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.07589115
14Protein export_Homo sapiens_hsa030601.98670006
15Nicotine addiction_Homo sapiens_hsa050331.94837624
16Ribosome_Homo sapiens_hsa030101.94747832
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.93102291
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92640418
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85847086
20Cardiac muscle contraction_Homo sapiens_hsa042601.82759554
21Basal transcription factors_Homo sapiens_hsa030221.81246646
22Histidine metabolism_Homo sapiens_hsa003401.78492559
23PPAR signaling pathway_Homo sapiens_hsa033201.76733136
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.74361267
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73285116
26Retinol metabolism_Homo sapiens_hsa008301.70571769
27Huntingtons disease_Homo sapiens_hsa050161.70001702
28Melanogenesis_Homo sapiens_hsa049161.69446814
29Proteasome_Homo sapiens_hsa030501.67459067
30Linoleic acid metabolism_Homo sapiens_hsa005911.65425709
31Homologous recombination_Homo sapiens_hsa034401.64208983
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63066481
33Chemical carcinogenesis_Homo sapiens_hsa052041.59040971
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58962043
35RNA polymerase_Homo sapiens_hsa030201.55832979
36Fanconi anemia pathway_Homo sapiens_hsa034601.55365213
37Arginine biosynthesis_Homo sapiens_hsa002201.53722686
38Fatty acid metabolism_Homo sapiens_hsa012121.53421871
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.52679881
40Dorso-ventral axis formation_Homo sapiens_hsa043201.50178799
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.49808990
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48668813
43Propanoate metabolism_Homo sapiens_hsa006401.48518085
44Phenylalanine metabolism_Homo sapiens_hsa003601.47681820
45Alzheimers disease_Homo sapiens_hsa050101.47399851
46Morphine addiction_Homo sapiens_hsa050321.45977491
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43645160
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43130392
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.35655487
50Pyruvate metabolism_Homo sapiens_hsa006201.35469782
51Tyrosine metabolism_Homo sapiens_hsa003501.35311949
52Tryptophan metabolism_Homo sapiens_hsa003801.34505663
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28820006
54Staphylococcus aureus infection_Homo sapiens_hsa051501.27845949
55Selenocompound metabolism_Homo sapiens_hsa004501.27621839
56Collecting duct acid secretion_Homo sapiens_hsa049661.24693175
57GABAergic synapse_Homo sapiens_hsa047271.23596769
58Butanoate metabolism_Homo sapiens_hsa006501.20638416
59Regulation of autophagy_Homo sapiens_hsa041401.17732262
60Hippo signaling pathway_Homo sapiens_hsa043901.17185046
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15034979
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14507457
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12826747
64Taste transduction_Homo sapiens_hsa047421.08872611
65beta-Alanine metabolism_Homo sapiens_hsa004101.04154207
66Olfactory transduction_Homo sapiens_hsa047401.03896730
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02876666
68Bile secretion_Homo sapiens_hsa049761.02747339
69Wnt signaling pathway_Homo sapiens_hsa043101.02508790
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02392022
71One carbon pool by folate_Homo sapiens_hsa006701.02295555
72Axon guidance_Homo sapiens_hsa043601.01494943
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00950456
74Glucagon signaling pathway_Homo sapiens_hsa049221.00525806
75Inositol phosphate metabolism_Homo sapiens_hsa005620.99602332
76Renin secretion_Homo sapiens_hsa049240.98970120
77Ether lipid metabolism_Homo sapiens_hsa005650.94792569
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94402991
79RNA degradation_Homo sapiens_hsa030180.92469456
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92359789
81Non-homologous end-joining_Homo sapiens_hsa034500.92351350
82ABC transporters_Homo sapiens_hsa020100.90985169
83Ovarian steroidogenesis_Homo sapiens_hsa049130.90365799
84Amoebiasis_Homo sapiens_hsa051460.88571233
85ECM-receptor interaction_Homo sapiens_hsa045120.85834290
86Calcium signaling pathway_Homo sapiens_hsa040200.84535837
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82665985
88Peroxisome_Homo sapiens_hsa041460.80969222
89Primary immunodeficiency_Homo sapiens_hsa053400.78244158
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.75577367
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75340905
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.74802475
93Proteoglycans in cancer_Homo sapiens_hsa052050.74014584
94Fatty acid biosynthesis_Homo sapiens_hsa000610.73995322
95Sulfur metabolism_Homo sapiens_hsa009200.73737542
96* Metabolic pathways_Homo sapiens_hsa011000.73628612
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71646871
98Vitamin B6 metabolism_Homo sapiens_hsa007500.71402151
99Dopaminergic synapse_Homo sapiens_hsa047280.71095100
100Arachidonic acid metabolism_Homo sapiens_hsa005900.70013585
101Purine metabolism_Homo sapiens_hsa002300.69652817
102Fructose and mannose metabolism_Homo sapiens_hsa000510.66622016
103Asthma_Homo sapiens_hsa053100.65155646
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64173998
105Lysine degradation_Homo sapiens_hsa003100.63474640
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.63012880
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61192811
108Glutamatergic synapse_Homo sapiens_hsa047240.60396743
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59619733
110Amphetamine addiction_Homo sapiens_hsa050310.57858912
111Protein digestion and absorption_Homo sapiens_hsa049740.57591818
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55722598
113Pyrimidine metabolism_Homo sapiens_hsa002400.55466814
114Fat digestion and absorption_Homo sapiens_hsa049750.55225000
115Nucleotide excision repair_Homo sapiens_hsa034200.54449807
116RNA transport_Homo sapiens_hsa030130.53791892
117Phototransduction_Homo sapiens_hsa047440.53171813
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51560396
119Glycerolipid metabolism_Homo sapiens_hsa005610.51130633
120Mineral absorption_Homo sapiens_hsa049780.50754484
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50085313
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.49074482
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49062412
124GnRH signaling pathway_Homo sapiens_hsa049120.48284110
125Folate biosynthesis_Homo sapiens_hsa007900.47776076
126Caffeine metabolism_Homo sapiens_hsa002320.47132605
127Long-term depression_Homo sapiens_hsa047300.45570061
128Synaptic vesicle cycle_Homo sapiens_hsa047210.44661525
129Sulfur relay system_Homo sapiens_hsa041220.44485081
130Oxytocin signaling pathway_Homo sapiens_hsa049210.44106853
131Insulin secretion_Homo sapiens_hsa049110.42846879
132Type I diabetes mellitus_Homo sapiens_hsa049400.41485250
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40480522
134Cholinergic synapse_Homo sapiens_hsa047250.40307296
135Salivary secretion_Homo sapiens_hsa049700.39253879
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38710632
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36835688
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36446236
139Sphingolipid metabolism_Homo sapiens_hsa006000.36316754
140Mismatch repair_Homo sapiens_hsa034300.35802586
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.34851780
142TNF signaling pathway_Homo sapiens_hsa046680.33685378
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32514228
144Estrogen signaling pathway_Homo sapiens_hsa049150.32343242
145Drug metabolism - other enzymes_Homo sapiens_hsa009830.31975613
146Arginine and proline metabolism_Homo sapiens_hsa003300.31791014
147Steroid biosynthesis_Homo sapiens_hsa001000.31017710
148Pathways in cancer_Homo sapiens_hsa052000.29768500
149Circadian entrainment_Homo sapiens_hsa047130.29092314
150Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28916268
151Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28551369
152Gastric acid secretion_Homo sapiens_hsa049710.28141176
153Dilated cardiomyopathy_Homo sapiens_hsa054140.24959327
154Serotonergic synapse_Homo sapiens_hsa047260.24093791
155Adherens junction_Homo sapiens_hsa045200.23180238
156Type II diabetes mellitus_Homo sapiens_hsa049300.23109165
157Pancreatic secretion_Homo sapiens_hsa049720.22089977

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