HYDIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may be involved in cilia motility. Mutations in this gene cause of autosomal recessive primary ciliary dyskinesia-5, a disorder characterized by the accumulation of cerebrospinal fluid within the ventricles of the brain. A duplicate copy of this gene has been found in humans on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.79358254
2piRNA metabolic process (GO:0034587)9.78762711
3acrosome assembly (GO:0001675)9.63962333
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.58548599
5sperm-egg recognition (GO:0035036)9.40340352
6regulation of cilium movement (GO:0003352)9.21179130
7motile cilium assembly (GO:0044458)9.05280862
8plasma membrane fusion (GO:0045026)8.69760905
9acrosome reaction (GO:0007340)8.43730883
10binding of sperm to zona pellucida (GO:0007339)8.41673483
11cell-cell recognition (GO:0009988)8.36109507
12male meiosis (GO:0007140)8.27890038
13cell wall macromolecule catabolic process (GO:0016998)8.07087515
14cell wall macromolecule metabolic process (GO:0044036)8.07087515
15reproduction (GO:0000003)7.78228200
16spermatid development (GO:0007286)7.72540140
17synaptonemal complex organization (GO:0070193)7.23000196
18synaptonemal complex assembly (GO:0007130)6.84812261
19single fertilization (GO:0007338)6.77859301
20sperm capacitation (GO:0048240)6.26662540
21DNA methylation involved in gamete generation (GO:0043046)6.15156529
22* ventricular system development (GO:0021591)5.91639828
23axoneme assembly (GO:0035082)5.91235329
24fertilization (GO:0009566)5.87271470
25regulation of microtubule-based movement (GO:0060632)5.59489979
26male meiosis I (GO:0007141)5.54590963
27microtubule severing (GO:0051013)5.41333745
28protein polyglutamylation (GO:0018095)5.08791420
29spermatogenesis (GO:0007283)5.04086744
30negative regulation of inclusion body assembly (GO:0090084)5.03125407
31male gamete generation (GO:0048232)5.02090875
32protein localization to cilium (GO:0061512)4.93041317
33chromosome organization involved in meiosis (GO:0070192)4.90027391
34meiotic nuclear division (GO:0007126)4.86977319
35intraciliary transport (GO:0042073)4.79091382
36meiotic cell cycle (GO:0051321)4.78958884
37germ cell development (GO:0007281)4.65926160
38gamete generation (GO:0007276)4.65064796
39cellular process involved in reproduction in multicellular organism (GO:0022412)4.61085819
40meiosis I (GO:0007127)4.46921617
41microtubule depolymerization (GO:0007019)4.44532563
42retinal rod cell development (GO:0046548)4.33387937
43primary alcohol catabolic process (GO:0034310)4.29623612
44nucleoside diphosphate phosphorylation (GO:0006165)4.24055731
45organic cation transport (GO:0015695)4.21693887
46left/right pattern formation (GO:0060972)4.21471394
47cell recognition (GO:0008037)4.18145049
48vitamin transmembrane transport (GO:0035461)4.15711129
49one-carbon compound transport (GO:0019755)4.04472911
50regulation of inclusion body assembly (GO:0090083)3.99148373
51* microtubule-based movement (GO:0007018)3.96828112
52lateral ventricle development (GO:0021670)3.88770084
53seminiferous tubule development (GO:0072520)3.86836625
54gene silencing by RNA (GO:0031047)3.83950920
55left/right axis specification (GO:0070986)3.83050022
56diterpenoid biosynthetic process (GO:0016102)3.80474303
57ethanol metabolic process (GO:0006067)3.79712559
58* cilium organization (GO:0044782)3.79661096
59genitalia morphogenesis (GO:0035112)3.75708379
60determination of left/right symmetry (GO:0007368)3.74855952
61smoothened signaling pathway (GO:0007224)3.72151984
62regulation of response to osmotic stress (GO:0047484)3.71134557
63calcium ion-dependent exocytosis (GO:0017156)3.70921563
64nuclear pore complex assembly (GO:0051292)3.70065171
65GTP biosynthetic process (GO:0006183)3.69681653
66multicellular organismal reproductive process (GO:0048609)3.68963443
67determination of bilateral symmetry (GO:0009855)3.61091133
68response to xenobiotic stimulus (GO:0009410)3.61089612
69* cilium assembly (GO:0042384)3.56835767
70retinal cone cell development (GO:0046549)3.55824135
71nonmotile primary cilium assembly (GO:0035058)3.54838199
72specification of symmetry (GO:0009799)3.53911195
73lung epithelium development (GO:0060428)3.52592714
74spermatid nucleus differentiation (GO:0007289)3.50770647
75regulation of centriole replication (GO:0046599)3.48995359
76negative regulation of organelle assembly (GO:1902116)3.48490710
77cilium morphogenesis (GO:0060271)3.47627747
78photoreceptor cell maintenance (GO:0045494)3.44288323
79microtubule bundle formation (GO:0001578)3.44168105
80UTP biosynthetic process (GO:0006228)3.41831082
81glomerular epithelial cell development (GO:0072310)3.40775824
82* cellular component assembly involved in morphogenesis (GO:0010927)3.38717543
83regulation of meiosis I (GO:0060631)3.37736886
84centriole replication (GO:0007099)3.32639607
85regulation of interleukin-5 production (GO:0032674)3.30823250
86microtubule polymerization or depolymerization (GO:0031109)3.29292833
87cytoplasmic microtubule organization (GO:0031122)3.23339861
88monoubiquitinated protein deubiquitination (GO:0035520)3.22825468
89centriole assembly (GO:0098534)3.19785057
90negative regulation of T cell differentiation in thymus (GO:0033085)3.19092557
91meiotic cell cycle process (GO:1903046)3.15864507
92establishment of planar polarity (GO:0001736)3.12707889
93establishment of tissue polarity (GO:0007164)3.12707889
94negative regulation of B cell mediated immunity (GO:0002713)3.10810121
95negative regulation of immunoglobulin mediated immune response (GO:0002890)3.10810121
96lateral sprouting from an epithelium (GO:0060601)3.09582460
97chaperone-mediated protein complex assembly (GO:0051131)3.05662703
98UTP metabolic process (GO:0046051)3.04722444
99synapsis (GO:0007129)3.02535759
100pyrimidine-containing compound transmembrane transport (GO:0072531)3.01780895
101regulation of protein polyubiquitination (GO:1902914)2.99673879
102nuclear pore organization (GO:0006999)2.98543306
103negative regulation of humoral immune response (GO:0002921)2.97238831
104positive regulation of smoothened signaling pathway (GO:0045880)2.96051190
105multicellular organismal development (GO:0007275)2.94369010
106retinoic acid metabolic process (GO:0042573)2.90245987
107establishment of apical/basal cell polarity (GO:0035089)2.88112004
108pore complex assembly (GO:0046931)2.82969614
109ethanol oxidation (GO:0006069)2.79957774
110intra-S DNA damage checkpoint (GO:0031573)2.79849233
111establishment of monopolar cell polarity (GO:0061162)2.79533215
112establishment or maintenance of monopolar cell polarity (GO:0061339)2.79533215
113peptidyl-glutamic acid modification (GO:0018200)2.76731677
114regulation of interleukin-13 production (GO:0032656)2.71534330
115limb development (GO:0060173)2.68080336
116appendage development (GO:0048736)2.68080336
117gene silencing (GO:0016458)2.64388506
118terpenoid biosynthetic process (GO:0016114)2.63783804
119nucleus organization (GO:0006997)2.63578457
120DNA replication-dependent nucleosome organization (GO:0034723)2.63156824
121DNA replication-dependent nucleosome assembly (GO:0006335)2.63156824
122apical protein localization (GO:0045176)2.60802187
123exogenous drug catabolic process (GO:0042738)2.60139358
124regulation of smoothened signaling pathway (GO:0008589)2.59039056
125tolerance induction (GO:0002507)2.57923865
126DNA methylation (GO:0006306)2.57174309
127DNA alkylation (GO:0006305)2.57174309
128regulation of spindle checkpoint (GO:0090231)2.55451541
129spinal cord motor neuron differentiation (GO:0021522)2.52893696
130chromosome condensation (GO:0030261)2.52638657
131asymmetric protein localization (GO:0008105)2.52627581
132* microtubule-based process (GO:0007017)2.45774920
133DNA packaging (GO:0006323)2.44850268
134carnitine transmembrane transport (GO:1902603)2.43668316
135amino-acid betaine transport (GO:0015838)2.42957946
136carnitine transport (GO:0015879)2.42957946
137guanosine-containing compound biosynthetic process (GO:1901070)2.42862415
138heart looping (GO:0001947)2.42138386
139regulation of germinal center formation (GO:0002634)2.41012965
140brain morphogenesis (GO:0048854)2.39620252
141establishment of nucleus localization (GO:0040023)2.37349016
142* cell projection assembly (GO:0030031)2.36952503
143* organelle assembly (GO:0070925)2.36646884
144negative regulation of JUN kinase activity (GO:0043508)2.32564252
145glutathione derivative biosynthetic process (GO:1901687)2.29853522
146glutathione derivative metabolic process (GO:1901685)2.29853522
147negative regulation of cytosolic calcium ion concentration (GO:0051481)2.28532088
148O-glycan processing (GO:0016266)2.27525888
149regulation of collateral sprouting (GO:0048670)2.25915029
150neural tube formation (GO:0001841)2.24116962
151eye photoreceptor cell differentiation (GO:0001754)2.22394307
152photoreceptor cell differentiation (GO:0046530)2.22394307
153embryonic heart tube morphogenesis (GO:0003143)2.21984311
154drug catabolic process (GO:0042737)2.20007116
155carnitine metabolic process (GO:0009437)2.19957034
156excretion (GO:0007588)2.18889873
157regulation of cilium assembly (GO:1902017)2.17973229
158regulation of vacuole organization (GO:0044088)2.16779697
159aldehyde catabolic process (GO:0046185)2.16654827
160retina layer formation (GO:0010842)2.12454829
161cilium or flagellum-dependent cell motility (GO:0001539)17.2824087
162axonemal dynein complex assembly (GO:0070286)12.1524021
163fusion of sperm to egg plasma membrane (GO:0007342)11.4999796
164epithelial cilium movement (GO:0003351)10.8508046
165* cilium movement (GO:0003341)10.4445297
166sperm motility (GO:0030317)10.0186712

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.72855561
2EZH2_22144423_ChIP-Seq_EOC_Human4.87694433
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.14755563
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.07302602
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.85362920
6DROSHA_22980978_ChIP-Seq_HELA_Human2.80068807
7GBX2_23144817_ChIP-Seq_PC3_Human2.76798871
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42067578
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.37393992
10PIAS1_25552417_ChIP-Seq_VCAP_Human2.33445083
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.32913078
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.24305700
13FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.17756875
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.13081367
15PCGF2_27294783_Chip-Seq_NPCs_Mouse2.06152378
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02263264
17* SMAD4_21799915_ChIP-Seq_A2780_Human1.94475368
18AR_21572438_ChIP-Seq_LNCaP_Human1.93688321
19ELK4_26923725_Chip-Seq_MESODERM_Mouse1.92455597
20VDR_22108803_ChIP-Seq_LS180_Human1.87906608
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87206964
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85523427
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84669454
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81513845
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80894179
26AHR_22903824_ChIP-Seq_MCF-7_Human1.78923437
27* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.77250003
28RNF2_27304074_Chip-Seq_NSC_Mouse1.76449974
29* STAT3_23295773_ChIP-Seq_U87_Human1.74412612
30* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.73305790
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72479840
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70415077
33* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.70071667
34ARNT_22903824_ChIP-Seq_MCF-7_Human1.66794871
35KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.63681983
36WDR5_24793694_ChIP-Seq_LNCAP_Human1.63185975
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63131155
38FUS_26573619_Chip-Seq_HEK293_Human1.61105458
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59928742
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.57612029
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.57373563
42* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56643145
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56518591
44TAF15_26573619_Chip-Seq_HEK293_Human1.56503613
45P300_19829295_ChIP-Seq_ESCs_Human1.56172852
46KAP1_22055183_ChIP-Seq_ESCs_Mouse1.56097103
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53713935
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.53502108
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52877322
50BCAT_22108803_ChIP-Seq_LS180_Human1.51755398
51NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.50578320
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.49659044
53IGF1R_20145208_ChIP-Seq_DFB_Human1.49213831
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49194040
55* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.48917113
56* TCF4_23295773_ChIP-Seq_U87_Human1.48867149
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.46521641
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.46521641
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.46521641
60TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.43055350
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.41441691
62TP53_18474530_ChIP-ChIP_U2OS_Human1.41195794
63TP53_16413492_ChIP-PET_HCT116_Human1.38175517
64MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37953049
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.36428950
66* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36311262
67TCF4_22108803_ChIP-Seq_LS180_Human1.35370088
68ESR1_20079471_ChIP-ChIP_T-47D_Human1.33529143
69SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.32894051
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30571987
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30571987
72FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29755456
73RUNX2_22187159_ChIP-Seq_PCA_Human1.29292750
74AR_25329375_ChIP-Seq_VCAP_Human1.28710063
75REST_21632747_ChIP-Seq_MESCs_Mouse1.28072084
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28033440
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27087905
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26106066
79ZNF274_21170338_ChIP-Seq_K562_Hela1.25333939
80OCT4_18555785_Chip-Seq_ESCs_Mouse1.24607340
81CBP_20019798_ChIP-Seq_JUKART_Human1.24580275
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24580275
83GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.23276338
84ER_23166858_ChIP-Seq_MCF-7_Human1.22780814
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20623497
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.20334340
87STAT1_17558387_ChIP-Seq_HELA_Human1.20155853
88* TAL1_26923725_Chip-Seq_HPCs_Mouse1.20121277
89* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19666913
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19541753
91TP63_23658742_ChIP-Seq_EP156T_Human1.18995099
92GATA3_21867929_ChIP-Seq_CD8_Mouse1.18803825
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18356849
94ETV1_20927104_ChIP-Seq_GIST48_Human1.17511265
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.17066845
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17049753
97SOX2_22085726_ChIP-Seq_NPCs_Mouse1.16807225
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16798428
99STAT3_18555785_ChIP-Seq_MESCs_Mouse1.16781611
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16737819
101ESRRB_18555785_Chip-Seq_ESCs_Mouse1.16571122
102EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16485397
103TBL1_22424771_ChIP-Seq_293T_Human1.15153282
104KLF4_18555785_Chip-Seq_ESCs_Mouse1.14961121
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.13399852
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13233907
107SPI1_26923725_Chip-Seq_HPCs_Mouse1.12030693
108EWS_26573619_Chip-Seq_HEK293_Human1.10651796
109CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10641867
110PHF8_20622853_ChIP-Seq_HELA_Human1.10362778
111GATA3_21867929_ChIP-Seq_TH1_Mouse1.10238730
112PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.10228040
113SMRT_27268052_Chip-Seq_Bcells_Human1.09963928
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09963379
115FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09939038
116E2F1_17053090_ChIP-ChIP_MCF-7_Human1.09914863
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09642941
118GF1_26923725_Chip-Seq_HPCs_Mouse1.09571509
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09112997
120LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.08718154
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08425592
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.08175812
123P300_18555785_Chip-Seq_ESCs_Mouse1.07630425
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06788677
125AR_19668381_ChIP-Seq_PC3_Human1.06504551
126BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05618066
127EZH2_27294783_Chip-Seq_ESCs_Mouse1.04975020
128CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04786219
129STAT3_18555785_Chip-Seq_ESCs_Mouse1.04559476
130NANOG_18555785_Chip-Seq_ESCs_Mouse1.04216708
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03719840
132RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03715451
133* SMAD3_21741376_ChIP-Seq_HESCs_Human1.03385561
134NFYB_21822215_ChIP-Seq_K562_Human1.02484794
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02354406
136NFYA_21822215_ChIP-Seq_K562_Human1.01856972
137ZFX_18555785_Chip-Seq_ESCs_Mouse1.01631023
138CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00037217
139* SMAD4_21741376_ChIP-Seq_HESCs_Human0.99491854
140ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99329446
141LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98948121
142CTCF_18555785_Chip-Seq_ESCs_Mouse0.98936268
143PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98935733
144KDM2B_26808549_Chip-Seq_REH_Human0.98727789
145YY1_22570637_ChIP-Seq_MALME-3M_Human0.98642203
146HNFA_21074721_ChIP-Seq_CACO-2_Human0.98441736
147EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98002592
148KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97847097
149STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97284695
150SMAD3_21741376_ChIP-Seq_ESCs_Human0.97163656
151CMYC_18555785_Chip-Seq_ESCs_Mouse0.97159191
152FLI1_21867929_ChIP-Seq_TH2_Mouse0.97152320
153CRX_20693478_ChIP-Seq_RETINA_Mouse0.96949867
154EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96936788
155CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96581646
156BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96122928
157* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95780126
158FOXA1_25552417_ChIP-Seq_VCAP_Human0.95301873
159ESET_19884257_ChIP-Seq_ESCs_Mouse0.93844526
160RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93596161
161CBX2_22325352_ChIP-Seq_293T-Rex_Human0.93227100
162OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93023403
163SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92765519
164STAT1_20625510_ChIP-Seq_HELA_Human0.92445150
165EZH2_27294783_Chip-Seq_NPCs_Mouse0.91813652
166P53_22387025_ChIP-Seq_ESCs_Mouse0.91515974
167RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89667285
168GF1B_26923725_Chip-Seq_HPCs_Mouse0.88830966
169SMAD1_18555785_Chip-Seq_ESCs_Mouse0.88345058
170MYC_27129775_Chip-Seq_CORNEA_Mouse0.88205917
171FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87744182
172E2F1_18555785_Chip-Seq_ESCs_Mouse0.87073274
173SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.86174645
174SOX2_18555785_Chip-Seq_ESCs_Mouse0.85731749
175MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85507005

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.48254148
2MP0008877_abnormal_DNA_methylation5.36425557
3MP0001929_abnormal_gametogenesis5.08614326
4MP0008875_abnormal_xenobiotic_pharmacok4.37409538
5MP0002210_abnormal_sex_determination3.78040715
6MP0001145_abnormal_male_reproductive3.19841715
7MP0004043_abnormal_pH_regulation3.16657384
8* MP0002161_abnormal_fertility/fecundity3.00952294
9MP0000383_abnormal_hair_follicle2.99789755
10MP0008057_abnormal_DNA_replication2.92082211
11MP0000653_abnormal_sex_gland2.73929591
12MP0000566_synostosis2.68786222
13MP0009780_abnormal_chondrocyte_physiolo2.60788392
14MP0008789_abnormal_olfactory_epithelium2.42784337
15MP0001485_abnormal_pinna_reflex2.19317165
16MP0010678_abnormal_skin_adnexa2.16943174
17MP0003136_yellow_coat_color2.15865293
18MP0002638_abnormal_pupillary_reflex2.10408414
19MP0005410_abnormal_fertilization13.0904419
20MP0002160_abnormal_reproductive_system1.90900689
21MP0008995_early_reproductive_senescence1.90389577
22MP0002734_abnormal_mechanical_nocicepti1.88472531
23MP0008058_abnormal_DNA_repair1.80213746
24MP0002735_abnormal_chemical_nociception1.62912667
25MP0001984_abnormal_olfaction1.60049265
26MP0002909_abnormal_adrenal_gland1.59825603
27MP0003011_delayed_dark_adaptation1.55065698
28MP0010094_abnormal_chromosome_stability1.51458050
29MP0004019_abnormal_vitamin_homeostasis1.43738690
30MP0002168_other_aberrant_phenotype1.38577048
31MP0010030_abnormal_orbit_morphology1.36146310
32MP0003786_premature_aging1.36141976
33MP0004133_heterotaxia1.35235164
34MP0005377_hearing/vestibular/ear_phenot1.28933797
35MP0003878_abnormal_ear_physiology1.28933797
36MP0009745_abnormal_behavioral_response1.28917955
37MP0005248_abnormal_Harderian_gland1.28040429
38MP0005670_abnormal_white_adipose1.25746086
39MP0001346_abnormal_lacrimal_gland1.23208727
40MP0001970_abnormal_pain_threshold1.22616183
41MP0000569_abnormal_digit_pigmentation1.21635916
42MP0005646_abnormal_pituitary_gland1.20322193
43MP0001963_abnormal_hearing_physiology1.19534279
44* MP0009046_muscle_twitch1.19165887
45MP0002557_abnormal_social/conspecific_i1.18443745
46MP0003646_muscle_fatigue1.18056298
47MP0005647_abnormal_sex_gland1.17620178
48MP0001293_anophthalmia1.17419550
49MP0003880_abnormal_central_pattern1.17065370
50MP0001502_abnormal_circadian_rhythm1.16525327
51MP0002876_abnormal_thyroid_physiology1.15742622
52MP0003879_abnormal_hair_cell1.14649931
53MP0005195_abnormal_posterior_eye1.11195083
54MP0003890_abnormal_embryonic-extraembry1.11163691
55MP0001968_abnormal_touch/_nociception1.10255011
56MP0002272_abnormal_nervous_system1.09284660
57* MP0002572_abnormal_emotion/affect_behav1.07399685
58MP0004264_abnormal_extraembryonic_tissu1.07213471
59MP0003950_abnormal_plasma_membrane1.07098120
60MP0005389_reproductive_system_phenotype1.05343037
61MP0002229_neurodegeneration1.04266914
62MP0004859_abnormal_synaptic_plasticity1.04250169
63MP0005394_taste/olfaction_phenotype1.03871121
64MP0005499_abnormal_olfactory_system1.03871121
65MP0005395_other_phenotype1.02262216
66MP0006276_abnormal_autonomic_nervous1.01430265
67* MP0002653_abnormal_ependyma_morphology0.96226948
68MP0006292_abnormal_olfactory_placode0.95589167
69MP0003111_abnormal_nucleus_morphology0.95584302
70MP0004270_analgesia0.95517661
71MP0004233_abnormal_muscle_weight0.95499155
72MP0004142_abnormal_muscle_tone0.95063204
73MP0002736_abnormal_nociception_after0.94307014
74MP0003656_abnormal_erythrocyte_physiolo0.92037681
75MP0002882_abnormal_neuron_morphology0.91850143
76MP0005220_abnormal_exocrine_pancreas0.91089191
77MP0001501_abnormal_sleep_pattern0.90411253
78MP0002064_seizures0.88957646
79MP0002067_abnormal_sensory_capabilities0.87465820
80MP0003195_calcinosis0.87150700
81MP0000427_abnormal_hair_cycle0.87034931
82MP0003633_abnormal_nervous_system0.86637326
83MP0004858_abnormal_nervous_system0.86289250
84MP0003635_abnormal_synaptic_transmissio0.85786384
85MP0002092_abnormal_eye_morphology0.85263145
86MP0008872_abnormal_physiological_respon0.84417361
87MP0005391_vision/eye_phenotype0.84165718
88MP0004885_abnormal_endolymph0.83886068
89MP0002063_abnormal_learning/memory/cond0.82139850
90MP0004742_abnormal_vestibular_system0.82010454
91MP0002084_abnormal_developmental_patter0.79031709
92MP0005636_abnormal_mineral_homeostasis0.78973511
93MP0001529_abnormal_vocalization0.76672209
94MP0005253_abnormal_eye_physiology0.74969776
95MP0005503_abnormal_tendon_morphology0.74333186
96MP0001944_abnormal_pancreas_morphology0.74058878
97MP0005083_abnormal_biliary_tract0.73969698
98* MP0003861_abnormal_nervous_system0.73861560
99MP0002928_abnormal_bile_duct0.72993756
100MP0008007_abnormal_cellular_replicative0.72855769
101MP0001765_abnormal_ion_homeostasis0.68891621
102MP0002132_abnormal_respiratory_system0.68120983
103MP0002102_abnormal_ear_morphology0.67813182
104MP0002085_abnormal_embryonic_tissue0.67247632
105MP0002254_reproductive_system_inflammat0.65545620
106MP0005075_abnormal_melanosome_morpholog0.64755067
107MP0005380_embryogenesis_phenotype0.63776922
108MP0001672_abnormal_embryogenesis/_devel0.63776922
109MP0000358_abnormal_cell_content/0.63365721
110MP0002233_abnormal_nose_morphology0.61143659
111MP0002332_abnormal_exercise_endurance0.59084638
112MP0001849_ear_inflammation0.57382861
113MP0000778_abnormal_nervous_system0.57382232
114* MP0002282_abnormal_trachea_morphology0.57360278
115MP0003699_abnormal_female_reproductive0.57081017
116MP0002249_abnormal_larynx_morphology0.56039134
117* MP0000432_abnormal_head_morphology0.55059628
118MP0005551_abnormal_eye_electrophysiolog0.54616500
119MP0003937_abnormal_limbs/digits/tail_de0.53147406
120* MP0002152_abnormal_brain_morphology0.52544932
121MP0001119_abnormal_female_reproductive0.52407758
122MP0003077_abnormal_cell_cycle0.51736802
123MP0002752_abnormal_somatic_nervous0.50544588
124MP0005423_abnormal_somatic_nervous0.50526083
125MP0000955_abnormal_spinal_cord0.50380949
126MP0009115_abnormal_fat_cell0.49213731
127MP0003938_abnormal_ear_development0.48989402
128MP0003984_embryonic_growth_retardation0.48503430
129MP0000049_abnormal_middle_ear0.48214225
130MP0003942_abnormal_urinary_system0.47742588
131MP0004957_abnormal_blastocyst_morpholog0.47736611
132MP0003115_abnormal_respiratory_system0.47565280
133MP0002088_abnormal_embryonic_growth/wei0.46382075
134MP0000313_abnormal_cell_death0.45922731
135MP0008932_abnormal_embryonic_tissue0.45879229
136MP0006072_abnormal_retinal_apoptosis0.45725778
137MP0003787_abnormal_imprinting0.45565019
138* MP0002116_abnormal_craniofacial_bone0.44649658
139MP0001730_embryonic_growth_arrest0.44371759
140MP0004381_abnormal_hair_follicle0.44311896
141MP0003121_genomic_imprinting0.44287629
142MP0002277_abnormal_respiratory_mucosa0.42568866
143MP0003283_abnormal_digestive_organ0.42119773
144MP0006035_abnormal_mitochondrial_morpho0.41999187
145MP0002234_abnormal_pharynx_morphology0.41696536
146MP0001727_abnormal_embryo_implantation0.41675903
147MP0000026_abnormal_inner_ear0.41596485
148MP0003935_abnormal_craniofacial_develop0.40543441
149MP0001324_abnormal_eye_pigmentation0.40516433
150MP0000631_abnormal_neuroendocrine_gland0.40098158
151MP0002127_abnormal_cardiovascular_syste0.39738842
152MP0000647_abnormal_sebaceous_gland0.39496112
153MP0003045_fibrosis0.39402106
154* MP0002114_abnormal_axial_skeleton0.39278986
155MP0001440_abnormal_grooming_behavior0.38322797
156MP0005266_abnormal_metabolism0.38205680
157MP0001486_abnormal_startle_reflex0.38203847

Predicted human phenotypes

RankGene SetZ-score
1* Abnormal respiratory motile cilium physiology (HP:0012261)9.90732403
2Abnormal respiratory motile cilium morphology (HP:0005938)9.50772803
3Abnormal respiratory epithelium morphology (HP:0012253)9.50772803
4* Abnormal ciliary motility (HP:0012262)8.36728982
5* Rhinitis (HP:0012384)7.82459761
6Chronic bronchitis (HP:0004469)7.18508747
7Infertility (HP:0000789)5.40874849
8* Bronchiectasis (HP:0002110)4.86593054
9Nephronophthisis (HP:0000090)4.45081969
10* Nasal polyposis (HP:0100582)4.17811469
11Abnormality of the lower motor neuron (HP:0002366)3.93861315
12* Bronchitis (HP:0012387)3.47884844
13Abnormality of the renal medulla (HP:0100957)3.43486419
14* Abnormality of the nasal mucosa (HP:0000433)3.36045066
15Male infertility (HP:0003251)3.27556688
16Abnormality of midbrain morphology (HP:0002418)3.11974988
17Molar tooth sign on MRI (HP:0002419)3.11974988
18Tubulointerstitial nephritis (HP:0001970)2.85471861
19Amyotrophic lateral sclerosis (HP:0007354)2.80953734
20Medial flaring of the eyebrow (HP:0010747)2.77708451
21Supernumerary spleens (HP:0009799)2.77587280
22Postaxial foot polydactyly (HP:0001830)2.68443348
23* Recurrent otitis media (HP:0000403)2.63899883
24Chronic otitis media (HP:0000389)2.62336123
25Hyperactive renin-angiotensin system (HP:0000841)2.47984541
26Impulsivity (HP:0100710)2.47401675
27Facial cleft (HP:0002006)2.46008257
28Fibular hypoplasia (HP:0003038)2.44886783
29Sclerocornea (HP:0000647)2.42829467
30Median cleft lip (HP:0000161)2.42356125
31Congenital hepatic fibrosis (HP:0002612)2.42239822
32Tubular atrophy (HP:0000092)2.42074167
33Pancreatic fibrosis (HP:0100732)2.36357251
34Atelectasis (HP:0100750)2.32036264
35Abnormal biliary tract physiology (HP:0012439)2.27653834
36Bile duct proliferation (HP:0001408)2.27653834
37Tubulointerstitial abnormality (HP:0001969)2.24327938
38Abnormal spermatogenesis (HP:0008669)2.22850387
39Chronic sinusitis (HP:0011109)2.21225302
40Abnormality of dentin (HP:0010299)2.19528328
41Furrowed tongue (HP:0000221)2.16116250
42* Recurrent sinusitis (HP:0011108)2.12828802
43Gonadotropin excess (HP:0000837)2.10939084
44* Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.1174183
45Dynein arm defect of respiratory motile cilia (HP:0012255)11.4378927
46Absent/shortened dynein arms (HP:0200106)11.4378927
47True hermaphroditism (HP:0010459)1.99545946
48Postaxial hand polydactyly (HP:0001162)1.98468958
49Stage 5 chronic kidney disease (HP:0003774)1.98286166
50Gait imbalance (HP:0002141)1.98132506
51Congenital primary aphakia (HP:0007707)1.97593556
52Abnormality of the dental root (HP:0006486)1.97277453
53Taurodontia (HP:0000679)1.97277453
54Abnormality of permanent molar morphology (HP:0011071)1.97277453
55Upper motor neuron abnormality (HP:0002127)1.93103950
56Oculomotor apraxia (HP:0000657)1.92894987
57Short ribs (HP:0000773)1.90710888
58Cystic liver disease (HP:0006706)1.88072205
59Nephroblastoma (Wilms tumor) (HP:0002667)1.87967499
60Abnormality of molar (HP:0011077)1.85819468
61Abnormality of molar morphology (HP:0011070)1.85819468
62Impaired proprioception (HP:0010831)1.85284529
63Abnormality of the dental pulp (HP:0006479)1.81909111
64Aplasia/Hypoplasia of the tongue (HP:0010295)1.80808295
65Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80574090
66Azoospermia (HP:0000027)1.80002406
67Microglossia (HP:0000171)1.79666799
68Absent frontal sinuses (HP:0002688)1.79152404
69Decreased circulating renin level (HP:0003351)1.76006329
70Bifid tongue (HP:0010297)1.75670092
71Nephropathy (HP:0000112)1.72315604
72Embryonal renal neoplasm (HP:0011794)1.72150728
73Renal dysplasia (HP:0000110)1.72111261
74Tubulointerstitial fibrosis (HP:0005576)1.70276068
75Spastic tetraparesis (HP:0001285)1.67926424
76Nephrogenic diabetes insipidus (HP:0009806)1.66517038
77Aplasia/Hypoplasia of the spleen (HP:0010451)1.62645191
78Asplenia (HP:0001746)1.62385325
79Abnormality of the renal cortex (HP:0011035)1.58888919
80Poor coordination (HP:0002370)1.57997843
81Occipital encephalocele (HP:0002085)1.57894389
82Short thorax (HP:0010306)1.57367413
83Abnormal rod and cone electroretinograms (HP:0008323)1.55931064
84Genital tract atresia (HP:0001827)1.54086995
85Pancreatic cysts (HP:0001737)1.53585375
86Abdominal situs inversus (HP:0003363)1.52748599
87Abnormality of abdominal situs (HP:0011620)1.52748599
88Abnormal drinking behavior (HP:0030082)1.52567954
89Polydipsia (HP:0001959)1.52567954
90Aplasia/Hypoplasia of the fibula (HP:0006492)1.52426450
91Heterotopia (HP:0002282)1.50528294
92Narrow forehead (HP:0000341)1.50365645
93Renal salt wasting (HP:0000127)1.50326901
94Polyuria (HP:0000103)1.44894664
95Hyperkalemia (HP:0002153)1.43225186
96Vaginal atresia (HP:0000148)1.42970969
97Sloping forehead (HP:0000340)1.42620158
98Hyperaldosteronism (HP:0000859)1.41825375
99Hypoplasia of the capital femoral epiphysis (HP:0003090)1.39540741
100Anencephaly (HP:0002323)1.39127269
101Tongue fasciculations (HP:0001308)1.39119130
102Preaxial hand polydactyly (HP:0001177)1.39090626
103Chromosomal breakage induced by crosslinking agents (HP:0003221)1.38778997
104Bilateral microphthalmos (HP:0007633)1.38763456
105Abnormality of the anterior horn cell (HP:0006802)1.37898201
106Degeneration of anterior horn cells (HP:0002398)1.37898201
107Cone-rod dystrophy (HP:0000548)1.37249716
108Prominent nasal bridge (HP:0000426)1.37142807
109Abnormality of ocular smooth pursuit (HP:0000617)1.36764272
110Absent speech (HP:0001344)1.35903839
111J-shaped sella turcica (HP:0002680)1.35874465
112Abnormality of renin-angiotensin system (HP:0000847)1.35101510
113Bell-shaped thorax (HP:0001591)1.34879646
114Aplasia/Hypoplasia of the lens (HP:0008063)1.33591589
115Decreased central vision (HP:0007663)1.33385933
116Selective tooth agenesis (HP:0001592)1.31827088
117Abnormality of renal excretion (HP:0011036)1.31412293
118Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.31185179
119Intellectual disability, moderate (HP:0002342)1.31148277
120Hemiparesis (HP:0001269)1.30910628
121Highly arched eyebrow (HP:0002553)1.30896020
122Chronic hepatic failure (HP:0100626)1.30524703
123Short humerus (HP:0005792)1.30379594
124Male pseudohermaphroditism (HP:0000037)1.30273235
125Aganglionic megacolon (HP:0002251)1.29848906
126Retinitis pigmentosa (HP:0000510)1.29742495
127Abnormal urine output (HP:0012590)1.24663313
128Anophthalmia (HP:0000528)1.23781255
129Optic nerve coloboma (HP:0000588)1.23139046
130Multicystic kidney dysplasia (HP:0000003)1.19460051
131Hypokalemic alkalosis (HP:0001949)1.18546219
132Abnormality of chloride homeostasis (HP:0011422)1.18095184
133Broad foot (HP:0001769)1.17546255
134Bony spicule pigmentary retinopathy (HP:0007737)1.17038955
135Abnormality of macular pigmentation (HP:0008002)1.16611174
136Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.15416119

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.44581306
2PDK47.44581306
3PDK24.78238339
4MST43.70831828
5ICK3.60277599
6PNCK3.48925590
7TESK13.42273009
8CDK123.25895369
9PRKD33.23093191
10FRK3.12289923
11MAPK153.06908985
12CASK2.31821342
13WNK42.29799693
14PTK2B2.21857481
15STK392.20836858
16INSRR2.06083428
17TYRO31.95216034
18BCR1.84778964
19NEK21.76856740
20TTK1.76062731
21WNK11.67913562
22GRK51.62855200
23GRK11.52884713
24WEE11.39737408
25STK381.39634955
26MAP2K71.29640612
27NME11.29028557
28MAP4K21.29010102
29MAPK131.28172235
30EPHA31.24267373
31CDC71.21706024
32MAP3K21.21019677
33MAPKAPK31.16220444
34EPHA41.14071520
35BMPR1B1.13994194
36LATS11.13741787
37DYRK31.08333549
38MAP3K71.04672374
39CHEK21.04053472
40DYRK1B1.03834159
41NTRK20.97914693
42TLK10.95692366
43NTRK30.93208886
44MET0.92546587
45STK240.90839385
46ERBB20.87149220
47STK30.86390415
48MARK10.85747668
49TNIK0.83943154
50GRK60.83491043
51OXSR10.80768698
52CAMK1G0.80047878
53FGFR20.79089647
54CHEK10.79070507
55LMTK20.77921765
56PLK10.77654627
57ADRBK20.72914073
58TSSK60.69791984
59PINK10.69675762
60ERBB30.67077222
61STK100.66444842
62SGK20.65828611
63IRAK10.62122623
64MAP2K40.60969187
65ACVR1B0.60593423
66ADRBK10.60242350
67PDK10.59853929
68PKN10.59770202
69DYRK1A0.58178987
70TRPM70.57874996
71ATM0.56960707
72RIPK10.56889348
73MATK0.56652312
74SGK2230.56053071
75SGK4940.56053071
76CDK70.55631274
77ATR0.54920245
78SGK10.52993958
79FER0.52694986
80CAMK2A0.51216119
81MTOR0.50457400
82EPHB10.49706358
83NLK0.49644262
84PRKCE0.49298819
85CAMKK10.48802252
86PAK20.48627711
87PRKAA20.47032766
88BRD40.45829276
89GRK70.44428677
90PRKCI0.44364041
91PAK30.43725917
92PRKACA0.43427164
93PASK0.43316251
94ROCK10.43295287
95PRKCQ0.43022222
96MARK20.42955206
97DDR20.42604106
98MAPKAPK50.41831902
99CSNK1G20.41425099
100ERN10.41367951
101DYRK20.41108705
102STK38L0.40088001
103CSK0.38910441
104PRKAA10.37046587
105CSF1R0.36918252
106TGFBR20.36828801
107PRKCZ0.35894731
108CAMKK20.35710431
109PRKG20.34305037
110AURKA0.34131658
111MAPK70.33944786
112CCNB10.33882250
113MAP2K60.33727314
114PRKCG0.33530686
115MAP3K30.32111079
116CDK30.31584466
117CDK50.31499279
118CSNK1G10.31228262
119CAMK2G0.30486483
120PRKCA0.29749628
121PAK10.29743738
122BRSK20.29636015
123EPHA20.29616422
124PLK40.27460089
125TGFBR10.27453375
126CDK20.25773039
127NEK60.25427198
128RET0.25306505
129MAPK100.25260483
130AKT30.24022661
131NEK90.23947509
132STK160.23921776
133CDK10.23005310
134LRRK20.22770392
135MOS0.21658408
136GSK3B0.21503446
137MAP3K40.21297270
138CSNK1D0.20705604
139PAK40.20170608
140PAK60.18443192
141CSNK1E0.18020510
142GSK3A0.17408542
143PHKG20.16739975
144PHKG10.16739975
145YES10.16502062
146CAMK40.15969658
147CDC42BPA0.15273500
148PRKDC0.15040632
149FGR0.13981957
150LATS20.13536974
151MAPK80.11559621
152MUSK0.11121714
153MAPK140.11110064
154WNK30.10446381
155PRKACG0.10438306
156MAPK10.10264781
157RPS6KA10.09554125
158PRKG10.09015009
159EEF2K0.08458412
160STK110.08385923
161BRSK10.08382989
162AURKB0.08005899
163RPS6KA30.07654067
164IRAK20.07459690
165PRKACB0.06779623

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.02322473
2Histidine metabolism_Homo sapiens_hsa003403.51315657
3Fanconi anemia pathway_Homo sapiens_hsa034603.37706998
4Dorso-ventral axis formation_Homo sapiens_hsa043203.24980488
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.99527689
6Fatty acid biosynthesis_Homo sapiens_hsa000612.90806840
7Basal transcription factors_Homo sapiens_hsa030222.87700331
8Phenylalanine metabolism_Homo sapiens_hsa003602.70732433
9Pyruvate metabolism_Homo sapiens_hsa006202.68027602
10beta-Alanine metabolism_Homo sapiens_hsa004102.65196561
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.58032611
12Linoleic acid metabolism_Homo sapiens_hsa005912.54751160
13Huntingtons disease_Homo sapiens_hsa050162.26463247
14Tyrosine metabolism_Homo sapiens_hsa003502.21284768
15Pentose phosphate pathway_Homo sapiens_hsa000302.05727678
16Glucagon signaling pathway_Homo sapiens_hsa049222.00095721
17Caffeine metabolism_Homo sapiens_hsa002321.97076015
18Oocyte meiosis_Homo sapiens_hsa041141.95319190
19mRNA surveillance pathway_Homo sapiens_hsa030151.92436767
20Fructose and mannose metabolism_Homo sapiens_hsa000511.87311738
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.86674167
22Propanoate metabolism_Homo sapiens_hsa006401.84102108
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82235273
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80902792
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.69768281
26RNA transport_Homo sapiens_hsa030131.68864123
27Selenocompound metabolism_Homo sapiens_hsa004501.57353135
28Glycerolipid metabolism_Homo sapiens_hsa005611.54290565
29Butanoate metabolism_Homo sapiens_hsa006501.52891109
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.51233664
31Ether lipid metabolism_Homo sapiens_hsa005651.48784747
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.44274443
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.43876771
34Nitrogen metabolism_Homo sapiens_hsa009101.41382055
35Circadian rhythm_Homo sapiens_hsa047101.37227653
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36504580
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36134112
38Hedgehog signaling pathway_Homo sapiens_hsa043401.34541969
39Homologous recombination_Homo sapiens_hsa034401.33349306
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31598590
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.30856054
42Arachidonic acid metabolism_Homo sapiens_hsa005901.29009221
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27468576
44Sphingolipid metabolism_Homo sapiens_hsa006001.26039583
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.23835910
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23762740
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21244992
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.16872222
49Taste transduction_Homo sapiens_hsa047421.15497308
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14448094
51Tryptophan metabolism_Homo sapiens_hsa003801.10344457
52Amphetamine addiction_Homo sapiens_hsa050311.09993504
53Peroxisome_Homo sapiens_hsa041461.09363755
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07410508
55PPAR signaling pathway_Homo sapiens_hsa033201.06918282
56Renin secretion_Homo sapiens_hsa049241.05569714
57Mineral absorption_Homo sapiens_hsa049781.00930754
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97746505
59Fatty acid degradation_Homo sapiens_hsa000710.97181869
60Cardiac muscle contraction_Homo sapiens_hsa042600.96657812
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94274861
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93839240
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92054708
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92002207
65Basal cell carcinoma_Homo sapiens_hsa052170.90928831
66Cocaine addiction_Homo sapiens_hsa050300.89527948
67Calcium signaling pathway_Homo sapiens_hsa040200.89254946
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88051937
69Cell cycle_Homo sapiens_hsa041100.86375378
70Purine metabolism_Homo sapiens_hsa002300.85995094
71Serotonergic synapse_Homo sapiens_hsa047260.81312943
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80954897
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80666143
74Inositol phosphate metabolism_Homo sapiens_hsa005620.80410927
75Olfactory transduction_Homo sapiens_hsa047400.80142395
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78110881
77RNA degradation_Homo sapiens_hsa030180.77704299
78ABC transporters_Homo sapiens_hsa020100.76752421
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75347056
80Estrogen signaling pathway_Homo sapiens_hsa049150.72566655
81GABAergic synapse_Homo sapiens_hsa047270.72099690
82Carbon metabolism_Homo sapiens_hsa012000.71522683
83Wnt signaling pathway_Homo sapiens_hsa043100.70211702
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69821300
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.69598077
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69426714
87Renin-angiotensin system_Homo sapiens_hsa046140.68974472
88Antigen processing and presentation_Homo sapiens_hsa046120.65511509
89Axon guidance_Homo sapiens_hsa043600.64696748
90Collecting duct acid secretion_Homo sapiens_hsa049660.63068484
91Starch and sucrose metabolism_Homo sapiens_hsa005000.62406152
92Chemical carcinogenesis_Homo sapiens_hsa052040.61882806
93Morphine addiction_Homo sapiens_hsa050320.59974985
94Ovarian steroidogenesis_Homo sapiens_hsa049130.59302785
95Long-term potentiation_Homo sapiens_hsa047200.57249164
96AMPK signaling pathway_Homo sapiens_hsa041520.56784290
97Biosynthesis of amino acids_Homo sapiens_hsa012300.55721159
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55130786
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55082345
100Glutathione metabolism_Homo sapiens_hsa004800.54037426
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.53975640
102Steroid biosynthesis_Homo sapiens_hsa001000.53582763
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52844276
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52302922
105Glutamatergic synapse_Homo sapiens_hsa047240.50767957
106Notch signaling pathway_Homo sapiens_hsa043300.50668300
107Tight junction_Homo sapiens_hsa045300.50544405
108Pancreatic secretion_Homo sapiens_hsa049720.50266933
109Nucleotide excision repair_Homo sapiens_hsa034200.49378695
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48650865
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48003121
112Regulation of autophagy_Homo sapiens_hsa041400.46517055
113Lysine degradation_Homo sapiens_hsa003100.46064061
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44934568
115Choline metabolism in cancer_Homo sapiens_hsa052310.44372693
116cAMP signaling pathway_Homo sapiens_hsa040240.43803813
117Salivary secretion_Homo sapiens_hsa049700.42510444
118Alcoholism_Homo sapiens_hsa050340.42376090
119Fat digestion and absorption_Homo sapiens_hsa049750.42089890
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41884768
121Hippo signaling pathway_Homo sapiens_hsa043900.40143213
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40014189
123Insulin secretion_Homo sapiens_hsa049110.39403447
124Arginine and proline metabolism_Homo sapiens_hsa003300.38186714
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.36178331
126Bile secretion_Homo sapiens_hsa049760.34784900
127Base excision repair_Homo sapiens_hsa034100.33367393
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32853237
129Dopaminergic synapse_Homo sapiens_hsa047280.32181547
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31801813
131Circadian entrainment_Homo sapiens_hsa047130.31239599
132Melanogenesis_Homo sapiens_hsa049160.31210590
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30547463
134Phototransduction_Homo sapiens_hsa047440.30401650
135Protein digestion and absorption_Homo sapiens_hsa049740.30312038
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30145904
137Adherens junction_Homo sapiens_hsa045200.30119860
138Oxytocin signaling pathway_Homo sapiens_hsa049210.29640501
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.29533944
140Gastric acid secretion_Homo sapiens_hsa049710.29333944
141Endocytosis_Homo sapiens_hsa041440.29239769
142Retinol metabolism_Homo sapiens_hsa008300.27863852
143Type II diabetes mellitus_Homo sapiens_hsa049300.27244173
144Spliceosome_Homo sapiens_hsa030400.26823257
145Thyroid hormone synthesis_Homo sapiens_hsa049180.26548930
146Metabolic pathways_Homo sapiens_hsa011000.25654306
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23450977
148Nicotine addiction_Homo sapiens_hsa050330.23345182
149VEGF signaling pathway_Homo sapiens_hsa043700.23059028

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