ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	serotonin metabolic process (GO:0042428)	4.91405315
2	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.88074392
3	astrocyte differentiation (GO:0048708)	4.36973716
4	primary amino compound metabolic process (GO:1901160)	4.27948295
5	L-amino acid import (GO:0043092)	4.24955568
6	presynaptic membrane assembly (GO:0097105)	4.12911105
7	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.97810192
8	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.89025283
9	axon ensheathment in central nervous system (GO:0032291)	3.87927965
10	central nervous system myelination (GO:0022010)	3.87927965
11	presynaptic membrane organization (GO:0097090)	3.75072640
12	membrane depolarization during action potential (GO:0086010)	3.67257970
13	negative regulation of neurotransmitter transport (GO:0051589)	3.64533347
14	astrocyte development (GO:0014002)	3.62050919
15	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.60628324
16	dermatan sulfate biosynthetic process (GO:0030208)	3.51809858
17	dopamine transport (GO:0015872)	3.50172765
18	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.48969074
19	postsynaptic membrane organization (GO:0001941)	3.41799103
20	regulation of glucocorticoid secretion (GO:2000849)	3.35151968
21	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.29124689
22	synaptic transmission, glutamatergic (GO:0035249)	3.27319013
23	eye photoreceptor cell differentiation (GO:0001754)	3.21139609
24	photoreceptor cell differentiation (GO:0046530)	3.21139609
25	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.20919031
26	glutamate receptor signaling pathway (GO:0007215)	3.19010925
27	dermatan sulfate metabolic process (GO:0030205)	3.17741866
28	amino acid import (GO:0043090)	3.14882738
29	catecholamine transport (GO:0051937)	3.05534793
30	neuron cell-cell adhesion (GO:0007158)	3.02200307
31	auditory behavior (GO:0031223)	2.99952852
32	positive regulation of synapse maturation (GO:0090129)	2.99029766
33	synaptic vesicle maturation (GO:0016188)	2.97772209
34	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.95510933
35	startle response (GO:0001964)	2.95244184
36	positive regulation of vascular permeability (GO:0043117)	2.91972413
37	vocalization behavior (GO:0071625)	2.89977399
38	neuronal ion channel clustering (GO:0045161)	2.87165444
39	insulin secretion (GO:0030073)	2.82416915
40	transmission of nerve impulse (GO:0019226)	2.81864742
41	fucose catabolic process (GO:0019317)	2.81749640
42	L-fucose metabolic process (GO:0042354)	2.81749640
43	L-fucose catabolic process (GO:0042355)	2.81749640
44	neuron-neuron synaptic transmission (GO:0007270)	2.81590188
45	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.81520483
46	gamma-aminobutyric acid transport (GO:0015812)	2.80044173
47	urinary tract smooth muscle contraction (GO:0014848)	2.78843355
48	water-soluble vitamin biosynthetic process (GO:0042364)	2.77335230
49	regulation of corticosteroid hormone secretion (GO:2000846)	2.77148558
50	positive regulation of membrane potential (GO:0045838)	2.76314482
51	response to auditory stimulus (GO:0010996)	2.75297236
52	regulation of synapse maturation (GO:0090128)	2.69284203
53	DNA damage induced protein phosphorylation (GO:0006975)	2.67981773
54	neurotransmitter secretion (GO:0007269)	2.67662747
55	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	2.67377179
56	protein localization to synapse (GO:0035418)	2.66746647
57	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	2.64525338
58	C4-dicarboxylate transport (GO:0015740)	2.64103106
59	membrane depolarization (GO:0051899)	2.64056712
60	neuron recognition (GO:0008038)	2.63788011
61	toxin metabolic process (GO:0009404)	2.63176330
62	neuronal action potential propagation (GO:0019227)	2.63108874
63	axonal fasciculation (GO:0007413)	2.62580878
64	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.61429787
65	response to corticosterone (GO:0051412)	2.60883194
66	neuronal action potential (GO:0019228)	2.59251770
67	neurotransmitter-gated ion channel clustering (GO:0072578)	2.59165894
68	nonmotile primary cilium assembly (GO:0035058)	2.58527862
69	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.58098763
70	central nervous system projection neuron axonogenesis (GO:0021952)	2.57808388
71	myelination (GO:0042552)	2.56823584
72	dopamine biosynthetic process (GO:0042416)	2.55677459
73	central nervous system neuron axonogenesis (GO:0021955)	2.55200396
74	cerebellar Purkinje cell differentiation (GO:0021702)	2.54207471
75	cerebellar granule cell differentiation (GO:0021707)	2.54085015
76	protein-chromophore linkage (GO:0018298)	2.53969115
77	locomotory exploration behavior (GO:0035641)	2.53961942
78	synaptic vesicle exocytosis (GO:0016079)	2.53556597
79	indole-containing compound metabolic process (GO:0042430)	2.52191821
80	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.52112797
81	phosphorelay signal transduction system (GO:0000160)	2.52055899
82	musculoskeletal movement (GO:0050881)	2.50969263
83	multicellular organismal movement (GO:0050879)	2.50969263
84	cochlea development (GO:0090102)	2.50239932
85	adult walking behavior (GO:0007628)	2.49545596
86	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	2.47751984
87	positive regulation of dendritic spine development (GO:0060999)	2.47719065
88	interkinetic nuclear migration (GO:0022027)	2.46985514
89	proline transport (GO:0015824)	2.46820912
90	regulation of neuronal synaptic plasticity (GO:0048168)	2.46660085
91	reflex (GO:0060004)	2.46410186
92	mechanosensory behavior (GO:0007638)	2.45679999
93	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.45416850
94	kidney morphogenesis (GO:0060993)	2.43710659
95	ensheathment of neurons (GO:0007272)	2.43656469
96	axon ensheathment (GO:0008366)	2.43656469
97	epithelial cell fate commitment (GO:0072148)	2.42889978
98	substrate-independent telencephalic tangential migration (GO:0021826)	2.41062208
99	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.41062208
100	glutamate secretion (GO:0014047)	2.40129330

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.71665704
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.10129039
3	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.57857048
4	DROSHA_22980978_ChIP-Seq_HELA_Human	2.29909385
5	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.28618260
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.26714868
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.25682208
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.22209427
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.17936445
10	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.11271166
11	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.08291422
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.03295524
13	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.96589311
14	SMAD4_21799915_ChIP-Seq_A2780_Human	1.95914361
15	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.94428962
16	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.90696653
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.89133477
18	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.84855273
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.79721321
20	REST_21632747_ChIP-Seq_MESCs_Mouse	1.72227283
21	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.68904643
22	STAT3_23295773_ChIP-Seq_U87_Human	1.68682857
23	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.68454387
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66200217
25	AHR_22903824_ChIP-Seq_MCF-7_Human	1.64432343
26	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.62307905
27	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.58553423
28	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.58450707
29	P300_19829295_ChIP-Seq_ESCs_Human	1.56722089
30	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.55826226
31	TCF4_23295773_ChIP-Seq_U87_Human	1.55196562
32	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.55066477
33	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.53339363
34	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47698752
35	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.47439440
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.44741979
37	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.44401396
38	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.44076778
39	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.42997615
40	AR_21572438_ChIP-Seq_LNCaP_Human	1.42182445
41	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.41657213
42	VDR_22108803_ChIP-Seq_LS180_Human	1.41180042
43	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40948641
44	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.40070897
45	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39432785
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39191889
47	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.39191889
48	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.38295419
49	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.37856684
50	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.37785646
51	AR_25329375_ChIP-Seq_VCAP_Human	1.37453732
52	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.37439051
53	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.36920278
54	TP53_16413492_ChIP-PET_HCT116_Human	1.36001474
55	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.34567982
56	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33995349
57	FUS_26573619_Chip-Seq_HEK293_Human	1.33489379
58	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.32416076
59	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.31716272
60	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.31658440
61	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.31519648
62	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.31344777
63	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.30388725
64	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.25882996
65	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.25882996
66	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.25880819
67	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.25433000
68	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.24078441
69	BCAT_22108803_ChIP-Seq_LS180_Human	1.22477756
70	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.20005851
71	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.19860201
72	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.19698107
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19614573
74	IGF1R_20145208_ChIP-Seq_DFB_Human	1.19184540
75	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.18861292
76	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.18577155
77	KDM2B_26808549_Chip-Seq_REH_Human	1.18344317
78	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.18325420
79	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.16529892
80	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.14139042
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13180118
82	AR_19668381_ChIP-Seq_PC3_Human	1.12739170
83	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12652813
84	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.12581304
85	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12240232
86	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11650928
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10832036
88	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.10435372
89	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.10435372
90	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.09853076
91	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.09509917
92	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.09340441
93	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08638852
94	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.06806505
95	CBP_20019798_ChIP-Seq_JUKART_Human	1.06559127
96	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.06559127
97	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.06401662
98	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.06245136
99	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05879008
100	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.05235855

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002638_abnormal_pupillary_reflex	3.89511924
2	MP0009046_muscle_twitch	3.77564904
3	MP0004859_abnormal_synaptic_plasticity	3.47625338
4	MP0003880_abnormal_central_pattern	3.08661946
5	MP0004270_analgesia	3.04635669
6	MP0001968_abnormal_touch/_nociception	3.00440389
7	MP0001501_abnormal_sleep_pattern	2.85123824
8	MP0003635_abnormal_synaptic_transmissio	2.75574913
9	MP0002064_seizures	2.74977584
10	MP0002736_abnormal_nociception_after	2.69745792
11	MP0009745_abnormal_behavioral_response	2.69311792
12	MP0002735_abnormal_chemical_nociception	2.68163076
13	MP0001502_abnormal_circadian_rhythm	2.48248618
14	MP0002272_abnormal_nervous_system	2.40706275
15	MP0002572_abnormal_emotion/affect_behav	2.38399335
16	MP0001486_abnormal_startle_reflex	2.27949187
17	MP0002063_abnormal_learning/memory/cond	2.26143400
18	MP0002909_abnormal_adrenal_gland	2.24361932
19	MP0002734_abnormal_mechanical_nocicepti	2.24276923
20	MP0005423_abnormal_somatic_nervous	2.20889060
21	MP0006276_abnormal_autonomic_nervous	2.20170324
22	MP0003879_abnormal_hair_cell	2.16697639
23	MP0009780_abnormal_chondrocyte_physiolo	2.16124080
24	MP0001984_abnormal_olfaction	2.12690527
25	MP0010386_abnormal_urinary_bladder	2.10434989
26	MP0001970_abnormal_pain_threshold	1.92516481
27	MP0000778_abnormal_nervous_system	1.79456974
28	MP0000569_abnormal_digit_pigmentation	1.75814147
29	MP0003633_abnormal_nervous_system	1.75103308
30	MP0005551_abnormal_eye_electrophysiolog	1.74922475
31	MP0002733_abnormal_thermal_nociception	1.74425616
32	MP0002557_abnormal_social/conspecific_i	1.66773772
33	MP0004885_abnormal_endolymph	1.64280053
34	MP0003690_abnormal_glial_cell	1.61878525
35	MP0001485_abnormal_pinna_reflex	1.60021606
36	MP0002067_abnormal_sensory_capabilities	1.59951627
37	MP0004924_abnormal_behavior	1.53728405
38	MP0005386_behavior/neurological_phenoty	1.53728405
39	MP0005253_abnormal_eye_physiology	1.52239086
40	MP0003631_nervous_system_phenotype	1.51442233
41	MP0003632_abnormal_nervous_system	1.50025750
42	MP0005646_abnormal_pituitary_gland	1.46193164
43	MP0001905_abnormal_dopamine_level	1.45135670
44	MP0003045_fibrosis	1.42707330
45	MP0002882_abnormal_neuron_morphology	1.34638161
46	MP0003195_calcinosis	1.33454467
47	MP0003950_abnormal_plasma_membrane	1.28565075
48	MP0005503_abnormal_tendon_morphology	1.27030562
49	MP0008569_lethality_at_weaning	1.26391510
50	MP0002229_neurodegeneration	1.24807602
51	MP0001440_abnormal_grooming_behavior	1.20599415
52	MP0003634_abnormal_glial_cell	1.17957852
53	MP0000920_abnormal_myelination	1.17301237
54	MP0008872_abnormal_physiological_respon	1.16209557
55	MP0004811_abnormal_neuron_physiology	1.16122087
56	MP0006072_abnormal_retinal_apoptosis	1.15237703
57	MP0000955_abnormal_spinal_cord	1.11092288
58	MP0003283_abnormal_digestive_organ	1.08908776
59	MP0002066_abnormal_motor_capabilities/c	1.05938180
60	MP0002876_abnormal_thyroid_physiology	1.04233217
61	MP0003136_yellow_coat_color	1.03230080
62	MP0002184_abnormal_innervation	1.02152520
63	MP0004742_abnormal_vestibular_system	0.99744940
64	MP0005595_abnormal_vascular_smooth	0.97607400
65	MP0003787_abnormal_imprinting	0.96908345
66	MP0000383_abnormal_hair_follicle	0.96898818
67	MP0000631_abnormal_neuroendocrine_gland	0.96010578
68	MP0002168_other_aberrant_phenotype	0.94927647
69	MP0001986_abnormal_taste_sensitivity	0.94893534
70	MP0001963_abnormal_hearing_physiology	0.92888785
71	MP0004085_abnormal_heartbeat	0.90224952
72	MP0005379_endocrine/exocrine_gland_phen	0.89970688
73	MP0005535_abnormal_body_temperature	0.88479065
74	MP0002653_abnormal_ependyma_morphology	0.88167436
75	MP0003137_abnormal_impulse_conducting	0.87664042
76	MP0005275_abnormal_skin_tensile	0.85418867
77	MP0005187_abnormal_penis_morphology	0.82283979
78	MP0002752_abnormal_somatic_nervous	0.81258261
79	MP0001944_abnormal_pancreas_morphology	0.80455450
80	MP0002152_abnormal_brain_morphology	0.78698297
81	MP0004043_abnormal_pH_regulation	0.77865702
82	MP0001177_atelectasis	0.75798465
83	MP0000026_abnormal_inner_ear	0.75390243
84	MP0005645_abnormal_hypothalamus_physiol	0.75106929
85	MP0002102_abnormal_ear_morphology	0.71729452
86	MP0003329_amyloid_beta_deposits	0.71542229
87	MP0002693_abnormal_pancreas_physiology	0.71472938
88	MP0004215_abnormal_myocardial_fiber	0.71022304
89	MP0005195_abnormal_posterior_eye	0.65887653
90	MP0000534_abnormal_ureter_morphology	0.64788417
91	MP0002069_abnormal_eating/drinking_beha	0.63787780
92	MP0005248_abnormal_Harderian_gland	0.63315033
93	MP0002078_abnormal_glucose_homeostasis	0.61213266
94	MP0000566_synostosis	0.60954711
95	MP0004142_abnormal_muscle_tone	0.59353409
96	MP0000462_abnormal_digestive_system	0.59129115
97	MP0001529_abnormal_vocalization	0.58695646
98	MP0000613_abnormal_salivary_gland	0.58561916
99	MP0000230_abnormal_systemic_arterial	0.58000762
100	MP0001299_abnormal_eye_distance/	0.57018854

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	6.71212105
2	Limb dystonia (HP:0002451)	4.38341320
3	Focal motor seizures (HP:0011153)	4.07967087
4	Diastasis recti (HP:0001540)	4.02977101
5	Mesangial abnormality (HP:0001966)	3.75363437
6	Distal arthrogryposis (HP:0005684)	3.53269824
7	Progressive cerebellar ataxia (HP:0002073)	3.41359643
8	Action tremor (HP:0002345)	3.27871089
9	Focal seizures (HP:0007359)	3.22647926
10	Absent speech (HP:0001344)	3.15663468
11	Epileptic encephalopathy (HP:0200134)	3.10764433
12	Difficulty running (HP:0009046)	3.06088877
13	Epileptiform EEG discharges (HP:0011182)	3.02326285
14	Metaphyseal dysplasia (HP:0100255)	3.01403807
15	Gaze-evoked nystagmus (HP:0000640)	2.98135448
16	Febrile seizures (HP:0002373)	2.97462952
17	Diplopia (HP:0000651)	2.96158462
18	Abnormality of binocular vision (HP:0011514)	2.96158462
19	Broad-based gait (HP:0002136)	2.88133302
20	Genetic anticipation (HP:0003743)	2.79530161
21	EEG with generalized epileptiform discharges (HP:0011198)	2.79274620
22	Hemiparesis (HP:0001269)	2.69927448
23	Hypsarrhythmia (HP:0002521)	2.66683091
24	Decreased circulating renin level (HP:0003351)	2.51460608
25	Abnormality of the ischium (HP:0003174)	2.50173989
26	Gait imbalance (HP:0002141)	2.48251832
27	Myokymia (HP:0002411)	2.45613150
28	Metabolic alkalosis (HP:0200114)	2.44806959
29	Hypothermia (HP:0002045)	2.38728689
30	Alacrima (HP:0000522)	2.36597731
31	Decreased lacrimation (HP:0000633)	2.34032278
32	Hypoplastic ischia (HP:0003175)	2.32546111
33	Hemiplegia (HP:0002301)	2.31609214
34	Dialeptic seizures (HP:0011146)	2.30951711
35	Bony spicule pigmentary retinopathy (HP:0007737)	2.27855061
36	Aplasia involving bones of the upper limbs (HP:0009823)	2.25489842
37	Aplasia of the phalanges of the hand (HP:0009802)	2.25489842
38	Aplasia involving bones of the extremities (HP:0009825)	2.25489842
39	Drooling (HP:0002307)	2.24095321
40	Hepatoblastoma (HP:0002884)	2.22354259
41	Atonic seizures (HP:0010819)	2.22072048
42	Absent frontal sinuses (HP:0002688)	2.20698703
43	Protruding tongue (HP:0010808)	2.20531443
44	Tubulointerstitial nephritis (HP:0001970)	2.20369105
45	Attenuation of retinal blood vessels (HP:0007843)	2.19191574
46	Cutaneous finger syndactyly (HP:0010554)	2.16702688
47	Medial flaring of the eyebrow (HP:0010747)	2.16546825
48	Generalized tonic-clonic seizures (HP:0002069)	2.15612761
49	Widely spaced teeth (HP:0000687)	2.13553522
50	Congenital primary aphakia (HP:0007707)	2.13389756
51	Abnormal ciliary motility (HP:0012262)	2.08852675
52	Cerebral hypomyelination (HP:0006808)	2.08106090
53	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.07004803
54	Prolonged QT interval (HP:0001657)	2.06507732
55	Pancreatic fibrosis (HP:0100732)	2.05436261
56	Genital tract atresia (HP:0001827)	2.04572371
57	Congenital sensorineural hearing impairment (HP:0008527)	2.04328965
58	Absence seizures (HP:0002121)	2.03908087
59	Excessive salivation (HP:0003781)	2.01643932
60	Nephrogenic diabetes insipidus (HP:0009806)	2.00294138
61	Lower limb muscle weakness (HP:0007340)	1.98047127
62	Nephronophthisis (HP:0000090)	1.96258698
63	Syncope (HP:0001279)	1.94423300
64	Prominent supraorbital ridges (HP:0000336)	1.91889675
65	Megalencephaly (HP:0001355)	1.90596192
66	Abnormality of the renal medulla (HP:0100957)	1.90106885
67	Vaginal atresia (HP:0000148)	1.89945378
68	Abnormal pupillary function (HP:0007686)	1.89396478
69	Agitation (HP:0000713)	1.86159390
70	Poor eye contact (HP:0000817)	1.86150459
71	Preaxial foot polydactyly (HP:0001841)	1.83626028
72	Short foot (HP:0001773)	1.82647341
73	Limb hypertonia (HP:0002509)	1.82064172
74	Abnormality of renin-angiotensin system (HP:0000847)	1.80580551
75	Choroideremia (HP:0001139)	1.80494088
76	Tubulointerstitial abnormality (HP:0001969)	1.79357141
77	Urinary bladder sphincter dysfunction (HP:0002839)	1.76576452
78	Abnormality of incisor morphology (HP:0011063)	1.76093374
79	Fragile skin (HP:0001030)	1.75387193
80	Pancreatic cysts (HP:0001737)	1.74521783
81	Focal segmental glomerulosclerosis (HP:0000097)	1.74411700
82	Abnormal rod and cone electroretinograms (HP:0008323)	1.73511737
83	Truncal ataxia (HP:0002078)	1.73311570
84	Protuberant abdomen (HP:0001538)	1.72891967
85	True hermaphroditism (HP:0010459)	1.72740618
86	Hypoplastic nipples (HP:0002557)	1.71497186
87	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.71332622
88	Bifid tongue (HP:0010297)	1.71219033
89	Postural instability (HP:0002172)	1.69676098
90	Thin upper lip vermilion (HP:0000219)	1.69279609
91	Protruding ear (HP:0000411)	1.68668952
92	Tetraplegia (HP:0002445)	1.68378919
93	Abnormal drinking behavior (HP:0030082)	1.68087547
94	Polydipsia (HP:0001959)	1.68087547
95	Short chin (HP:0000331)	1.67304409
96	Increased circulating renin level (HP:0000848)	1.66469896
97	Large eyes (HP:0001090)	1.66167773
98	Fair hair (HP:0002286)	1.65348158
99	Cutaneous syndactyly (HP:0012725)	1.65001035
100	Cystic liver disease (HP:0006706)	1.63331427

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.67481272
2	CASK	4.01547428
3	NTRK3	3.64351952
4	MARK1	2.94040111
5	PIK3CG	2.59693955
6	SGK2	2.42475742
7	CSNK1G1	2.20812682
8	INSRR	2.20510076
9	FGFR2	2.19180685
10	EPHA4	2.13918137
11	MAP3K4	2.11025486
12	CSNK1G2	2.09254293
13	TNIK	2.09106930
14	CSNK1G3	2.03216143
15	NTRK2	2.03089432
16	DAPK2	1.98420810
17	SGK223	1.92899345
18	SGK494	1.92899345
19	PNCK	1.79437170
20	MAPK13	1.71157699
21	SGK3	1.59274503
22	PHKG2	1.42997889
23	PHKG1	1.42997889
24	LATS1	1.31948697
25	CDK12	1.31078849
26	PINK1	1.22623492
27	PDK2	1.18577562
28	CCNB1	1.17416015
29	STK38L	1.15824955
30	AKT3	1.14751897
31	DMPK	1.14153010
32	WNK3	1.12493284
33	ADRBK2	1.12425769
34	MAP2K7	1.07724782
35	UHMK1	1.06747964
36	SGK1	1.04808142
37	CAMK1G	1.04612232
38	PRKCG	1.03802657
39	GRK1	1.00844267
40	MAP3K12	0.99372606
41	MYLK	0.98576358
42	PIK3CA	0.97263394
43	NUAK1	0.97215743
44	ERN1	0.96342776
45	PAK3	0.95374524
46	MAP3K2	0.95265681
47	CAMK1	0.94750580
48	ACVR1B	0.92081855
49	MAP3K7	0.89960448
50	CAMK2B	0.85866427
51	PKN1	0.84916545
52	PRKCE	0.84696033
53	CSNK1A1	0.83214344
54	TYRO3	0.82873447
55	MARK2	0.82316460
56	CDK5	0.79596904
57	OXSR1	0.79073869
58	CAMK2A	0.77863628
59	PRKCH	0.74762623
60	LMTK2	0.74659373
61	GSK3A	0.73093065
62	CSNK1D	0.72176125
63	DYRK1A	0.68717351
64	CAMK4	0.67804311
65	PDGFRB	0.67679815
66	PRKAA1	0.67333716
67	MINK1	0.67065505
68	MAPK10	0.66454600
69	NLK	0.65798679
70	STK39	0.62316409
71	CSNK1E	0.62147140
72	PTK2B	0.59947227
73	ROCK1	0.59673716
74	WNK1	0.58933423
75	CAMK2D	0.57809919
76	DAPK1	0.57787872
77	RPS6KA3	0.57278530
78	BMPR1B	0.56657625
79	STK38	0.55922703
80	MAP2K4	0.54526072
81	PRKCZ	0.53021998
82	CSNK1A1L	0.52489154
83	HIPK2	0.52297643
84	PRKG1	0.51035971
85	PAK6	0.50496315
86	PLK2	0.49106824
87	STK11	0.48383115
88	EPHA3	0.46964547
89	ADRBK1	0.45501763
90	ZAK	0.45161395
91	PRKACA	0.43024020
92	PDGFRA	0.42708600
93	FGFR3	0.42237556
94	NEK6	0.41837624
95	MAPK15	0.40795062
96	DDR2	0.40252537
97	NTRK1	0.40069995
98	CAMK2G	0.39089571
99	PRKAA2	0.38060135
100	ERBB2	0.36757464

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.44336980
2	Circadian rhythm_Homo sapiens_hsa04710	2.56288395
3	Amphetamine addiction_Homo sapiens_hsa05031	2.53466488
4	Circadian entrainment_Homo sapiens_hsa04713	2.47154148
5	Cocaine addiction_Homo sapiens_hsa05030	2.44815159
6	Insulin secretion_Homo sapiens_hsa04911	2.35804936
7	Glutamatergic synapse_Homo sapiens_hsa04724	2.35227045
8	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.09878491
9	GABAergic synapse_Homo sapiens_hsa04727	2.07879129
10	Nitrogen metabolism_Homo sapiens_hsa00910	1.94697217
11	Dopaminergic synapse_Homo sapiens_hsa04728	1.91982926
12	Morphine addiction_Homo sapiens_hsa05032	1.87574618
13	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.86581006
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.76263412
15	Histidine metabolism_Homo sapiens_hsa00340	1.75575515
16	Taste transduction_Homo sapiens_hsa04742	1.69087329
17	Serotonergic synapse_Homo sapiens_hsa04726	1.66876983
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.66797286
19	Salivary secretion_Homo sapiens_hsa04970	1.59523910
20	Renin secretion_Homo sapiens_hsa04924	1.51323657
21	Gastric acid secretion_Homo sapiens_hsa04971	1.51227213
22	Long-term potentiation_Homo sapiens_hsa04720	1.48417438
23	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.47703440
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.47309265
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.45255102
26	Type II diabetes mellitus_Homo sapiens_hsa04930	1.40337344
27	Calcium signaling pathway_Homo sapiens_hsa04020	1.37472956
28	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.36882167
29	Cholinergic synapse_Homo sapiens_hsa04725	1.35538778
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.34359895
31	Long-term depression_Homo sapiens_hsa04730	1.33985237
32	beta-Alanine metabolism_Homo sapiens_hsa00410	1.30683140
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.29055214
34	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.26230379
35	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.24740812
36	cAMP signaling pathway_Homo sapiens_hsa04024	1.24479551
37	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.20615338
38	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.17496161
39	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.14494602
40	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.14202311
41	ABC transporters_Homo sapiens_hsa02010	1.09855502
42	Pancreatic secretion_Homo sapiens_hsa04972	1.09020922
43	Butanoate metabolism_Homo sapiens_hsa00650	1.08108260
44	Bile secretion_Homo sapiens_hsa04976	1.06592789
45	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.04331552
46	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.02912441
47	Phototransduction_Homo sapiens_hsa04744	1.00048174
48	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.99808575
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.96764463
50	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.95619849
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.95448482
52	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.93191350
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.89629999
54	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.88612224
55	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.86696268
56	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.85895344
57	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.85873853
58	Linoleic acid metabolism_Homo sapiens_hsa00591	0.82448052
59	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.81250813
60	Olfactory transduction_Homo sapiens_hsa04740	0.79838430
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.79635409
62	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.79100323
63	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.78826742
64	Estrogen signaling pathway_Homo sapiens_hsa04915	0.75197444
65	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.73404323
66	Ras signaling pathway_Homo sapiens_hsa04014	0.71833492
67	Gap junction_Homo sapiens_hsa04540	0.70787212
68	GnRH signaling pathway_Homo sapiens_hsa04912	0.70042467
69	Rap1 signaling pathway_Homo sapiens_hsa04015	0.69490751
70	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.67150604
71	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.64868377
72	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.64866229
73	Axon guidance_Homo sapiens_hsa04360	0.64007297
74	Mineral absorption_Homo sapiens_hsa04978	0.63780567
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.63332496
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.61002151
77	Tight junction_Homo sapiens_hsa04530	0.60339034
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60306752
79	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.58627241
80	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.57827108
81	Wnt signaling pathway_Homo sapiens_hsa04310	0.56624454
82	Melanoma_Homo sapiens_hsa05218	0.55786808
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53985049
84	ECM-receptor interaction_Homo sapiens_hsa04512	0.50836636
85	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.48473148
86	Choline metabolism in cancer_Homo sapiens_hsa05231	0.48412179
87	Melanogenesis_Homo sapiens_hsa04916	0.45400734
88	MAPK signaling pathway_Homo sapiens_hsa04010	0.45285194
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.45051311
90	Cardiac muscle contraction_Homo sapiens_hsa04260	0.43914268
91	Protein digestion and absorption_Homo sapiens_hsa04974	0.43809722
92	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.41211741
93	ErbB signaling pathway_Homo sapiens_hsa04012	0.40917259
94	Hippo signaling pathway_Homo sapiens_hsa04390	0.40708103
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40641463
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.40554516
97	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.40255013
98	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.39109670
99	Platelet activation_Homo sapiens_hsa04611	0.37085384
100	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.36099933

HYDIN2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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