HYI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a putative hydroxypyruvate isomerase, which likely catalyzes the conversion of hydroxypyruvate to 2-hydroxy-3-oxopropanoate, and may be involved in carbohydrate transport and metabolism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.30193562
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.30193562
3L-phenylalanine metabolic process (GO:0006558)7.10138236
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.10138236
5aromatic amino acid family catabolic process (GO:0009074)6.60628913
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.01165929
7indole-containing compound catabolic process (GO:0042436)6.01012858
8indolalkylamine catabolic process (GO:0046218)6.01012858
9tryptophan catabolic process (GO:0006569)6.01012858
10kynurenine metabolic process (GO:0070189)5.72945393
11glyoxylate metabolic process (GO:0046487)5.68420783
12tryptophan metabolic process (GO:0006568)5.63151096
13bile acid biosynthetic process (GO:0006699)5.54101633
14sulfur amino acid catabolic process (GO:0000098)5.32688672
15alpha-linolenic acid metabolic process (GO:0036109)5.29594280
16high-density lipoprotein particle remodeling (GO:0034375)5.20066198
17protein carboxylation (GO:0018214)5.15568856
18peptidyl-glutamic acid carboxylation (GO:0017187)5.15568856
19cysteine metabolic process (GO:0006534)5.14212133
20urea cycle (GO:0000050)5.13447285
21urea metabolic process (GO:0019627)5.13447285
22negative regulation of fibrinolysis (GO:0051918)4.97355139
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.95477451
24aromatic amino acid family metabolic process (GO:0009072)4.81949852
25bile acid metabolic process (GO:0008206)4.79081282
26serine family amino acid catabolic process (GO:0009071)4.77877071
27regulation of fibrinolysis (GO:0051917)4.76544587
28nitrogen cycle metabolic process (GO:0071941)4.74834152
29complement activation, alternative pathway (GO:0006957)4.71814148
30regulation of cholesterol esterification (GO:0010872)4.67482540
31regulation of protein activation cascade (GO:2000257)4.65167542
32negative regulation of cholesterol transport (GO:0032375)4.53041544
33negative regulation of sterol transport (GO:0032372)4.53041544
34phospholipid efflux (GO:0033700)4.52311889
35cellular ketone body metabolic process (GO:0046950)4.50922572
36tyrosine metabolic process (GO:0006570)4.50906003
37regulation of triglyceride catabolic process (GO:0010896)4.50764699
38reverse cholesterol transport (GO:0043691)4.47972937
39amino-acid betaine metabolic process (GO:0006577)4.46755399
40plasma lipoprotein particle remodeling (GO:0034369)4.41826384
41protein-lipid complex remodeling (GO:0034368)4.41826384
42macromolecular complex remodeling (GO:0034367)4.41826384
43alpha-amino acid catabolic process (GO:1901606)4.39446902
44acylglycerol homeostasis (GO:0055090)4.39311719
45triglyceride homeostasis (GO:0070328)4.39311719
46lysine catabolic process (GO:0006554)4.39011617
47lysine metabolic process (GO:0006553)4.39011617
48cellular glucuronidation (GO:0052695)4.34277790
49regulation of complement activation (GO:0030449)4.32965719
50indolalkylamine metabolic process (GO:0006586)4.30182129
51homocysteine metabolic process (GO:0050667)4.29994736
52coenzyme catabolic process (GO:0009109)4.27924689
53bile acid and bile salt transport (GO:0015721)4.22290519
54aldehyde catabolic process (GO:0046185)4.21478376
55plasma lipoprotein particle clearance (GO:0034381)4.18438604
56amine catabolic process (GO:0009310)4.17700340
57cellular biogenic amine catabolic process (GO:0042402)4.17700340
58protein retention in ER lumen (GO:0006621)4.10873622
59cellular amino acid catabolic process (GO:0009063)4.09347224
60imidazole-containing compound metabolic process (GO:0052803)4.05835788
61benzene-containing compound metabolic process (GO:0042537)4.02309387
62drug catabolic process (GO:0042737)4.02219232
63glucuronate metabolic process (GO:0019585)4.01841806
64uronic acid metabolic process (GO:0006063)4.01841806
65ethanol oxidation (GO:0006069)4.01390505
66glycine metabolic process (GO:0006544)3.97162077
67glutamate metabolic process (GO:0006536)3.94728092
68regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.93336423
69cellular modified amino acid catabolic process (GO:0042219)3.90856213
70cholesterol efflux (GO:0033344)3.89742377
71ketone body metabolic process (GO:1902224)3.89373147
72serine family amino acid metabolic process (GO:0009069)3.88726053
73flavonoid metabolic process (GO:0009812)3.86211623
74plasma lipoprotein particle assembly (GO:0034377)3.85270768
75maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.83977819
76short-chain fatty acid metabolic process (GO:0046459)3.75628445
77drug transmembrane transport (GO:0006855)3.74077439
78low-density lipoprotein particle remodeling (GO:0034374)3.72975635
79endothelial cell chemotaxis (GO:0035767)3.72758298
80arginine metabolic process (GO:0006525)3.72653004
81cofactor catabolic process (GO:0051187)3.70725309
82positive regulation of triglyceride lipase activity (GO:0061365)3.69878744
83positive regulation of lipoprotein lipase activity (GO:0051006)3.69878744
84carboxylic acid catabolic process (GO:0046395)3.68881172
85organic acid catabolic process (GO:0016054)3.68881172
86regulation of cholesterol homeostasis (GO:2000188)3.65349585
87regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.63748070
88fibrinolysis (GO:0042730)3.63568212
89urate metabolic process (GO:0046415)3.62196088
90dicarboxylic acid biosynthetic process (GO:0043650)3.62076502
91blood coagulation, intrinsic pathway (GO:0007597)3.61956747
92positive regulation of lipid catabolic process (GO:0050996)3.59189967
93NAD biosynthetic process (GO:0009435)3.59010018
94serine family amino acid biosynthetic process (GO:0009070)3.58303378
95nicotinamide nucleotide biosynthetic process (GO:0019359)3.55675950
96pyridine nucleotide biosynthetic process (GO:0019363)3.55675950
97virion attachment to host cell (GO:0019062)3.54371285
98adhesion of symbiont to host cell (GO:0044650)3.54371285
99cholesterol homeostasis (GO:0042632)3.54091244
100acetyl-CoA metabolic process (GO:0006084)3.51012268
101monocarboxylic acid catabolic process (GO:0072329)3.50846870
102negative regulation of lipase activity (GO:0060192)3.50642077
103very-low-density lipoprotein particle assembly (GO:0034379)3.50422537
104sterol homeostasis (GO:0055092)3.48166892
105fatty acid oxidation (GO:0019395)3.47321065
106fatty acid beta-oxidation (GO:0006635)3.47136420
107phospholipid homeostasis (GO:0055091)3.46819257
108adhesion of symbiont to host (GO:0044406)3.18046604
109regulation of apoptotic process involved in morphogenesis (GO:1902337)3.13123263
110negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.11756132
111actin filament depolymerization (GO:0030042)3.10090066
112vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.08762525
113barbed-end actin filament capping (GO:0051016)3.07598493
114GDP-mannose metabolic process (GO:0019673)3.02273396
115renal filtration (GO:0097205)3.00681669
116protein maturation by protein folding (GO:0022417)2.97380824
117vascular endothelial growth factor signaling pathway (GO:0038084)2.94622369
118lymph vessel development (GO:0001945)2.94581121
119deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92782534
120positive regulation of fatty acid biosynthetic process (GO:0045723)2.88699330
121UV protection (GO:0009650)2.84286353
122regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.83987156
123cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.82586007
124basement membrane organization (GO:0071711)2.76568337
125endothelium development (GO:0003158)2.73649797
126positive regulation of systemic arterial blood pressure (GO:0003084)2.71623610
127regulation of plasminogen activation (GO:0010755)2.70003917
128extracellular fibril organization (GO:0043206)2.69404941
129positive regulation of pseudopodium assembly (GO:0031274)2.67876543
130positive regulation of protein kinase C signaling (GO:0090037)2.63346764
131hemidesmosome assembly (GO:0031581)2.63099036
132type B pancreatic cell proliferation (GO:0044342)2.62009682
133atrioventricular valve morphogenesis (GO:0003181)2.59746304
134positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.57735395
135positive regulation of blood vessel endothelial cell migration (GO:0043536)2.57686902
136glial cell migration (GO:0008347)2.57387654
137cell-substrate junction assembly (GO:0007044)2.56952586
138pattern specification involved in kidney development (GO:0061004)2.54797320
139epoxygenase P450 pathway (GO:0019373)2.53639524
140tonic smooth muscle contraction (GO:0014820)2.50416444
141glomerular filtration (GO:0003094)2.48156931
142macroautophagy (GO:0016236)2.48107471
143semaphorin-plexin signaling pathway (GO:0071526)2.46565684
144positive regulation of odontogenesis (GO:0042482)2.44420857
145COPI coating of Golgi vesicle (GO:0048205)2.44167760
146Golgi transport vesicle coating (GO:0048200)2.44167760
147negative regulation of cell size (GO:0045792)2.41271027
148ribosomal small subunit biogenesis (GO:0042274)2.40806048
149angiogenesis involved in wound healing (GO:0060055)2.39665578
150endocrine hormone secretion (GO:0060986)2.39407382
151venous blood vessel morphogenesis (GO:0048845)2.39177295
152negative regulation of blood vessel endothelial cell migration (GO:0043537)2.38373181
153renal system process involved in regulation of blood volume (GO:0001977)2.37667896
154positive regulation of vascular permeability (GO:0043117)2.37551400
155fibril organization (GO:0097435)2.36889632
156endocytic recycling (GO:0032456)2.34108907
157arginine catabolic process (GO:0006527)2.34059570
158negative regulation of fatty acid transport (GO:2000192)2.33917895
159regulation of pseudopodium assembly (GO:0031272)2.30195663
160regulation of blood vessel endothelial cell migration (GO:0043535)2.28680337
161adherens junction assembly (GO:0034333)2.28244945
162endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.27687836
163regulation of hydrogen peroxide metabolic process (GO:0010310)2.27601113
164endocrine process (GO:0050886)2.27397575
165regulation of systemic arterial blood pressure by hormone (GO:0001990)2.27397575
166regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.27397575
167mitochondrial calcium ion transport (GO:0006851)2.27257754
168focal adhesion assembly (GO:0048041)2.26845570
169cell-substrate adherens junction assembly (GO:0007045)2.26845570
170regulation of cholesterol metabolic process (GO:0090181)2.25605867
171negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.25022488
172protein localization to endosome (GO:0036010)2.24159036
173adenosine receptor signaling pathway (GO:0001973)2.22858483
174positive regulation of cartilage development (GO:0061036)2.22839571
175regulation of endothelial cell differentiation (GO:0045601)2.22691090
176prostanoid biosynthetic process (GO:0046457)2.22404058
177prostaglandin biosynthetic process (GO:0001516)2.22404058
178apoptotic cell clearance (GO:0043277)2.22298766
179mannose metabolic process (GO:0006013)2.21457832
180artery smooth muscle contraction (GO:0014824)2.21091542
181proline biosynthetic process (GO:0006561)2.19739272
182regulation of endothelial cell chemotaxis (GO:2001026)2.18622798
183endodermal cell differentiation (GO:0035987)2.18194640
184skin morphogenesis (GO:0043589)2.17983383
185Rho protein signal transduction (GO:0007266)2.17410145
186positive regulation of fatty acid metabolic process (GO:0045923)2.16896701
187negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.16363512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.88731414
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.79160098
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.39326341
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.97539856
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.16683441
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.98778518
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.88044023
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.86276135
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.75029635
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.45588850
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.96373603
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.71686652
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.64899324
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19314492
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.08061811
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.05552618
17* VDR_21846776_ChIP-Seq_THP-1_Human2.04164181
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1740336
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.90182235
20KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88286172
21CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.80798960
22UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.79789520
23P68_20966046_ChIP-Seq_HELA_Human1.78419125
24ZNF263_19887448_ChIP-Seq_K562_Human1.78244100
25CTCF_27219007_Chip-Seq_Bcells_Human1.72897173
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.71542220
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.70182456
28GATA1_22025678_ChIP-Seq_K562_Human1.64457830
29SA1_27219007_Chip-Seq_ERYTHROID_Human1.63849021
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62779701
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.61934382
32* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58198911
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57854513
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56900542
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55507264
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55456949
37TP53_22127205_ChIP-Seq_IMR90_Human1.54618564
38* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.51212880
39KDM2B_26808549_Chip-Seq_K562_Human1.49760123
40* KDM2B_26808549_Chip-Seq_DND41_Human1.47517575
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42151499
42CLOCK_20551151_ChIP-Seq_293T_Human1.41306267
43* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40721903
44SMC3_22415368_ChIP-Seq_MEFs_Mouse1.40665167
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.38338561
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37983278
47SMC4_20622854_ChIP-Seq_HELA_Human1.37079947
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36586176
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.36031731
50* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34477199
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32564766
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29097405
53CTCF_18555785_ChIP-Seq_MESCs_Mouse1.28154976
54CREB1_26743006_Chip-Seq_LNCaP_Human1.27748118
55HTT_18923047_ChIP-ChIP_STHdh_Human1.27633038
56* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27404109
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26668815
58* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26534485
59HNF4A_19822575_ChIP-Seq_HepG2_Human1.26364468
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22276531
61P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22064701
62SMC1_22415368_ChIP-Seq_MEFs_Mouse1.19494325
63TP63_22573176_ChIP-Seq_HFKS_Human1.18763063
64* SA1_27219007_Chip-Seq_Bcells_Human1.16915280
65* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16127373
66CTCF_20526341_ChIP-Seq_ESCs_Human1.14971337
67ATF3_27146783_Chip-Seq_COLON_Human1.14754467
68* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11235687
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10913648
70PHF8_20622854_ChIP-Seq_HELA_Human1.10612415
71* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10501481
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09672249
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09447560
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09304047
75E2F1_20622854_ChIP-Seq_HELA_Human1.08752045
76* UBF1/2_26484160_Chip-Seq_HMECs_Human1.07149033
77NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06196796
78CTCF_21964334_Chip-Seq_Bcells_Human1.05350004
79TCF7_22412390_ChIP-Seq_EML_Mouse1.05183450
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05113567
81ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03595265
82ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03183573
83SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02900539
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01297950
85SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00826413
86TP53_23651856_ChIP-Seq_MEFs_Mouse1.00786111
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00271657
88* TET1_21490601_ChIP-Seq_MESCs_Mouse1.00049368
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99565535
90ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99053508
91JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98882410
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98156583
93TP53_20018659_ChIP-ChIP_R1E_Mouse0.98115098
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97904309
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97253053
96CTCF_26484167_Chip-Seq_Bcells_Mouse0.96970220
97FOXP1_21924763_ChIP-Seq_HESCs_Human0.96882560
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.96059821
99YY1_22570637_ChIP-Seq_MALME-3M_Human0.95838178
100SCL_19346495_ChIP-Seq_HPC-7_Human0.94548008
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94505279
102* LXR_22292898_ChIP-Seq_THP-1_Human0.94277211
103MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92225147
104LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90005477
105BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87783471
106GATA4_25053715_ChIP-Seq_YYC3_Human0.87543235
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81950337
108GATA1_19941827_ChIP-Seq_MEL_Mouse0.81007618
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80787434
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79444956
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77745118
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76776262
113NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.76111546
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.74864157
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.72820566
116RARA_24833708_ChIP-Seq_LIVER_Mouse0.72041561
117TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.71616458
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70918489
119CDX2_20551321_ChIP-Seq_CACO-2_Human0.70905865
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.69602903
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.69308943
122ESR1_21235772_ChIP-Seq_MCF-7_Human0.69015116
123IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.68628324
124IRF8_27001747_Chip-Seq_BMDM_Mouse0.67143080
125* RARB_24833708_ChIP-Seq_LIVER_Mouse0.66074832
126BRD4_27068464_Chip-Seq_AML-cells_Mouse0.65980068
127KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65261333
128LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.63811631
129GATA1_19941826_ChIP-Seq_K562_Human0.63724280
130CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.63217817
131SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63057164
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.62083764
133BP1_19119308_ChIP-ChIP_Hs578T_Human0.61429933
134ESR1_15608294_ChIP-ChIP_MCF-7_Human0.61205460
135GATA1_22383799_ChIP-Seq_G1ME_Mouse0.61157070
136STAT3_1855785_ChIP-Seq_MESCs_Mouse0.60598911
137TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.59957867
138EGR1_19032775_ChIP-ChIP_M12_Human0.59848827
139AUTS2_25519132_ChIP-Seq_293T-REX_Human0.59415778
140AR_20517297_ChIP-Seq_VCAP_Human0.58267360
141PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58021562
142NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57723169
143AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.57232225
144CEBPB_22108803_ChIP-Seq_LS180_Human0.57163518
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.56694912
146BCL6_27268052_Chip-Seq_Bcells_Human0.56655703
147MYC_19915707_ChIP-ChIP_AK7_Human0.56357586
148GATA2_19941826_ChIP-Seq_K562_Human0.55667533
149IRF8_21731497_ChIP-ChIP_J774_Mouse0.54816065
150GATA6_25053715_ChIP-Seq_YYC3_Human0.53901626
151NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.53674268
152NRF2_20460467_ChIP-Seq_MEFs_Mouse0.53674268
153BCOR_27268052_Chip-Seq_Bcells_Human0.52159422
154SRY_22984422_ChIP-ChIP_TESTIS_Rat0.50836057
155ESET_19884257_ChIP-Seq_ESCs_Mouse0.50788249
156SOX2_20726797_ChIP-Seq_SW620_Human0.50023157
157CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.49488355
158FOXA1_25552417_ChIP-Seq_VCAP_Human0.49159203
159P53_21459846_ChIP-Seq_SAOS-2_Human0.48218161
160* RACK7_27058665_Chip-Seq_MCF-7_Human0.48134792
161GATA2_22383799_ChIP-Seq_G1ME_Mouse0.47654513
162TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.47085085
163PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.46875663
164TAF2_19829295_ChIP-Seq_ESCs_Human0.46481996
165GATA2_21666600_ChIP-Seq_HMVEC_Human0.46327429
166CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.46286516
167CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.46161374
168TET1_21451524_ChIP-Seq_MESCs_Mouse0.45773658
169MYB_21317192_ChIP-Seq_ERMYB_Mouse0.45721876

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.15100561
2MP0005360_urolithiasis7.27788695
3MP0005085_abnormal_gallbladder_physiolo5.94248319
4MP0005365_abnormal_bile_salt5.83622606
5MP0008875_abnormal_xenobiotic_pharmacok4.80359157
6MP0003806_abnormal_nucleotide_metabolis4.12541229
7MP0003252_abnormal_bile_duct3.66483024
8MP0010329_abnormal_lipoprotein_level3.38141813
9MP0009840_abnormal_foam_cell3.24548220
10MP0000013_abnormal_adipose_tissue3.19215669
11MP0005083_abnormal_biliary_tract2.94124640
12MP0004272_abnormal_basement_membrane2.83717577
13MP0005332_abnormal_amino_acid2.76738492
14MP0003195_calcinosis2.76471271
15MP0001666_abnormal_nutrient_absorption2.59787267
16MP0000003_abnormal_adipose_tissue2.56193345
17MP0008438_abnormal_cutaneous_collagen2.55531470
18MP0009379_abnormal_foot_pigmentation2.48152049
19MP0001958_emphysema2.35744072
20MP0003191_abnormal_cellular_cholesterol2.33610441
21MP0003279_aneurysm2.27052298
22MP0002138_abnormal_hepatobiliary_system2.20155324
23MP0004019_abnormal_vitamin_homeostasis2.19287696
24MP0001879_abnormal_lymphatic_vessel2.13884201
25MP0005375_adipose_tissue_phenotype2.12798470
26MP0000609_abnormal_liver_physiology2.08607976
27MP0005666_abnormal_adipose_tissue2.05602879
28MP0002118_abnormal_lipid_homeostasis2.05270989
29MP0003566_abnormal_cell_adhesion2.03203618
30MP0005257_abnormal_intraocular_pressure1.98321727
31MP0005623_abnormal_meninges_morphology1.96124515
32MP0003868_abnormal_feces_composition1.87444331
33MP0005319_abnormal_enzyme/_coenzyme1.85642852
34MP0009780_abnormal_chondrocyte_physiolo1.79002412
35MP0009384_cardiac_valve_regurgitation1.73092272
36MP0000751_myopathy1.66782794
37MP0005584_abnormal_enzyme/coenzyme_acti1.66131850
38MP0001764_abnormal_homeostasis1.66035276
39MP0000678_abnormal_parathyroid_gland1.60589028
40MP0005023_abnormal_wound_healing1.56875053
41MP0010030_abnormal_orbit_morphology1.55762534
42MP0009643_abnormal_urine_homeostasis1.53025206
43MP0002877_abnormal_melanocyte_morpholog1.51739836
44MP0005503_abnormal_tendon_morphology1.49137844
45MP0000343_altered_response_to1.47740351
46MP0005330_cardiomyopathy1.47322244
47MP0009697_abnormal_copulation1.47124921
48MP0003879_abnormal_hair_cell1.46471172
49MP0003186_abnormal_redox_activity1.45119356
50MP0005451_abnormal_body_composition1.40316619
51MP0004510_myositis1.36781280
52MP0006138_congestive_heart_failure1.33138511
53MP0009764_decreased_sensitivity_to1.20854628
54MP0000767_abnormal_smooth_muscle1.19607263
55MP0000598_abnormal_liver_morphology1.16767398
56MP0003656_abnormal_erythrocyte_physiolo1.16030547
57MP0005636_abnormal_mineral_homeostasis1.14922536
58MP0005595_abnormal_vascular_smooth1.14494903
59MP0005084_abnormal_gallbladder_morpholo1.13326577
60MP0005508_abnormal_skeleton_morphology1.11408002
61MP0005409_darkened_coat_color1.11261093
62MP0008469_abnormal_protein_level1.11101090
63MP0005501_abnormal_skin_physiology1.10480924
64MP0005165_increased_susceptibility_to1.09399322
65MP0003011_delayed_dark_adaptation1.09374869
66MP0003091_abnormal_cell_migration1.07835405
67MP0002932_abnormal_joint_morphology1.07499127
68MP0002249_abnormal_larynx_morphology1.07407934
69MP0004185_abnormal_adipocyte_glucose1.07073252
70MP0009763_increased_sensitivity_to1.05815730
71MP0000534_abnormal_ureter_morphology1.05174127
72MP0005647_abnormal_sex_gland1.03551405
73MP0002896_abnormal_bone_mineralization1.02534994
74MP0000604_amyloidosis0.99226781
75MP0002060_abnormal_skin_morphology0.96844677
76MP0009642_abnormal_blood_homeostasis0.96083492
77MP0000762_abnormal_tongue_morphology0.94595663
78MP0006036_abnormal_mitochondrial_physio0.94583636
79MP0005464_abnormal_platelet_physiology0.93143766
80MP0008004_abnormal_stomach_pH0.93095379
81MP0001849_ear_inflammation0.92311459
82MP0005408_hypopigmentation0.91892315
83MP0000750_abnormal_muscle_regeneration0.91257774
84MP0002933_joint_inflammation0.90542073
85MP0001664_abnormal_digestion0.90474799
86MP0000467_abnormal_esophagus_morphology0.88836437
87MP0009765_abnormal_xenobiotic_induced0.87855699
88MP0003436_decreased_susceptibility_to0.87704109
89MP0002876_abnormal_thyroid_physiology0.87621640
90MP0002796_impaired_skin_barrier0.87221237
91MP0000681_abnormal_thyroid_gland0.85867865
92MP0002078_abnormal_glucose_homeostasis0.85762588
93MP0001502_abnormal_circadian_rhythm0.85047692
94MP0003724_increased_susceptibility_to0.84244738
95MP0003453_abnormal_keratinocyte_physiol0.84083573
96MP0005220_abnormal_exocrine_pancreas0.83212248
97MP0009053_abnormal_anal_canal0.81509319
98MP0010368_abnormal_lymphatic_system0.81353218
99MP0003828_pulmonary_edema0.80893230
100MP0005535_abnormal_body_temperature0.79328909
101MP0000759_abnormal_skeletal_muscle0.79202758
102MP0005275_abnormal_skin_tensile0.78878158
103MP0005670_abnormal_white_adipose0.78563912
104MP0001348_abnormal_lacrimal_gland0.77527426
105MP0005058_abnormal_lysosome_morphology0.77262436
106MP0002295_abnormal_pulmonary_circulatio0.76743334
107MP0005334_abnormal_fat_pad0.76360916
108MP0004858_abnormal_nervous_system0.75582582
109MP0001756_abnormal_urination0.75571904
110MP0003705_abnormal_hypodermis_morpholog0.75483092
111MP0005376_homeostasis/metabolism_phenot0.75300494
112MP0002837_dystrophic_cardiac_calcinosis0.74292021
113MP0000163_abnormal_cartilage_morphology0.74076477
114MP0002928_abnormal_bile_duct0.73153492
115MP0001542_abnormal_bone_strength0.73144429
116MP0000733_abnormal_muscle_development0.73072938
117MP0003385_abnormal_body_wall0.70832746
118MP0001188_hyperpigmentation0.70713942
119MP0002254_reproductive_system_inflammat0.70579587
120MP0000462_abnormal_digestive_system0.69536015
121MP0001270_distended_abdomen0.68947265
122MP0002971_abnormal_brown_adipose0.68930932
123MP0002136_abnormal_kidney_physiology0.68388169
124MP0001614_abnormal_blood_vessel0.68216649
125MP0003283_abnormal_digestive_organ0.67523067
126MP0004130_abnormal_muscle_cell0.66832459
127MP0009785_altered_susceptibility_to0.64275088
128MP0006082_CNS_inflammation0.63026370
129MP0001661_extended_life_span0.61877062
130MP0003638_abnormal_response/metabolism_0.61735079
131MP0001845_abnormal_inflammatory_respons0.61073426
132MP0005266_abnormal_metabolism0.60992217
133MP0005448_abnormal_energy_balance0.59906255
134MP0000639_abnormal_adrenal_gland0.56597273
135MP0005025_abnormal_response_to0.55092273
136MP0000685_abnormal_immune_system0.52521101
137MP0001835_abnormal_antigen_presentation0.51483618
138MP0008874_decreased_physiological_sensi0.51301253
139MP0001853_heart_inflammation0.51181650
140MP0002419_abnormal_innate_immunity0.49914924
141MP0004782_abnormal_surfactant_physiolog0.49735865
142MP0003075_altered_response_to0.49015863
143MP0003953_abnormal_hormone_level0.48819145
144MP0003690_abnormal_glial_cell0.48111789
145MP0008873_increased_physiological_sensi0.47567487
146MP0005166_decreased_susceptibility_to0.47396508
147MP0003300_gastrointestinal_ulcer0.46148337
148MP0004043_abnormal_pH_regulation0.46054432
149MP0003329_amyloid_beta_deposits0.45354216
150MP0006035_abnormal_mitochondrial_morpho0.45134132
151MP0004947_skin_inflammation0.44346177
152MP0000230_abnormal_systemic_arterial0.42901069
153MP0001765_abnormal_ion_homeostasis0.42655105
154MP0010155_abnormal_intestine_physiology0.41091956
155MP0000249_abnormal_blood_vessel0.38790188
156MP0004381_abnormal_hair_follicle0.36907078
157MP0001944_abnormal_pancreas_morphology0.36828723
158MP0005075_abnormal_melanosome_morpholog0.36621093
159MP0002970_abnormal_white_adipose0.35569845
160MP0008872_abnormal_physiological_respon0.34763111
161MP0002135_abnormal_kidney_morphology0.33644834
162MP0004147_increased_porphyrin_level0.33517160
163MP0005387_immune_system_phenotype0.33252169
164MP0001790_abnormal_immune_system0.33252169
165MP0000538_abnormal_urinary_bladder0.33156939
166MP0003172_abnormal_lysosome_physiology0.32509070
167MP0001533_abnormal_skeleton_physiology0.32114912

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.36708041
2Intrahepatic cholestasis (HP:0001406)6.55668429
3Deep venous thrombosis (HP:0002625)6.48489389
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.00180921
5Prolonged partial thromboplastin time (HP:0003645)5.88119890
6Xanthomatosis (HP:0000991)5.84219465
7Hypobetalipoproteinemia (HP:0003563)5.82970314
8Hyperlipoproteinemia (HP:0010980)5.23147533
9Joint hemorrhage (HP:0005261)4.65179275
10Complement deficiency (HP:0004431)4.51537102
11Protrusio acetabuli (HP:0003179)4.41047038
12Hyperammonemia (HP:0001987)4.28988052
13Ketosis (HP:0001946)4.27675721
14Premature rupture of membranes (HP:0001788)4.21127996
15Hypolipoproteinemia (HP:0010981)4.18973001
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.11864102
17Hypoglycemic coma (HP:0001325)4.11247469
18Abnormality of the common coagulation pathway (HP:0010990)4.07935029
19Abnormality of sulfur amino acid metabolism (HP:0004339)3.97088759
20Abnormality of aspartate family amino acid metabolism (HP:0010899)3.96841293
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.91338598
22Hyperglycinemia (HP:0002154)3.91302003
23Abnormality of methionine metabolism (HP:0010901)3.88877817
24Epidermoid cyst (HP:0200040)3.73308968
25Fat malabsorption (HP:0002630)3.73086663
26Abnormality of the intrinsic pathway (HP:0010989)3.70488283
27Hyperglycinuria (HP:0003108)3.66951238
28Abnormality of fatty-acid metabolism (HP:0004359)3.63401852
29Vertebral compression fractures (HP:0002953)3.61350734
30Abnormality of glycine metabolism (HP:0010895)3.59670018
31Abnormality of serine family amino acid metabolism (HP:0010894)3.59670018
32Conjugated hyperbilirubinemia (HP:0002908)3.58881646
33Hypoalphalipoproteinemia (HP:0003233)3.53182560
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.52296715
35Cervical subluxation (HP:0003308)3.41505180
36Abnormality of pyrimidine metabolism (HP:0004353)3.34761272
37Hypercholesterolemia (HP:0003124)3.33991571
38Abnormality of complement system (HP:0005339)3.32663652
39Hyperbilirubinemia (HP:0002904)3.23707953
40Joint stiffness (HP:0001387)3.23094598
41Ketoacidosis (HP:0001993)3.20619454
42Delayed CNS myelination (HP:0002188)3.11908078
43Abnormality of nucleobase metabolism (HP:0010932)3.04753080
44Hypoglycemic seizures (HP:0002173)2.96644899
45Atrophic scars (HP:0001075)2.94792315
46Dicarboxylic aciduria (HP:0003215)2.93420513
47Abnormality of dicarboxylic acid metabolism (HP:0010995)2.93420513
48Abnormality of purine metabolism (HP:0004352)2.89748984
49Systemic lupus erythematosus (HP:0002725)2.89414541
50Axonal loss (HP:0003447)2.82342818
51Metabolic acidosis (HP:0001942)2.80190814
52Abnormality of serum amino acid levels (HP:0003112)2.79426856
53Gout (HP:0001997)2.77692006
54Generalized aminoaciduria (HP:0002909)2.76443906
55Distal lower limb amyotrophy (HP:0008944)2.76328269
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.74318631
57Abnormality of polysaccharide metabolism (HP:0011012)2.74318631
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.74318631
59Steatorrhea (HP:0002570)2.74027071
60Shallow orbits (HP:0000586)2.71670092
61Myocardial infarction (HP:0001658)2.71140132
62J-shaped sella turcica (HP:0002680)2.71012435
63Dysostosis multiplex (HP:0000943)2.70558227
64Spontaneous abortion (HP:0005268)2.65633452
65Broad face (HP:0000283)2.62743658
66Mucopolysacchariduria (HP:0008155)2.61087105
67Urinary glycosaminoglycan excretion (HP:0003541)2.61087105
68Hepatocellular carcinoma (HP:0001402)2.60594967
69Lethargy (HP:0001254)2.60245033
70Nuclear cataract (HP:0100018)2.59214102
71Short nail (HP:0001799)2.57571341
72Vascular calcification (HP:0004934)2.57443833
73Fragile skin (HP:0001030)2.56590026
74Menorrhagia (HP:0000132)2.51705370
75Achilles tendon contracture (HP:0001771)2.51265181
76Distal lower limb muscle weakness (HP:0009053)2.51065117
77Abnormality of the Achilles tendon (HP:0005109)2.50649658
78Gingival bleeding (HP:0000225)2.50564473
79Glomerulonephritis (HP:0000099)2.49237924
80Aortic aneurysm (HP:0004942)2.48729420
81Spinal rigidity (HP:0003306)2.46738832
82Increased variability in muscle fiber diameter (HP:0003557)2.46217851
83Hypochromic microcytic anemia (HP:0004840)2.43896328
84Cerebral edema (HP:0002181)2.43866497
85Skin nodule (HP:0200036)2.43107265
86Late onset (HP:0003584)2.41000797
87Amyloidosis (HP:0011034)2.39710534
88Symptomatic seizures (HP:0011145)2.34568801
89Irritability (HP:0000737)2.34228177
90Mitral stenosis (HP:0001718)2.30724292
91Stridor (HP:0010307)2.30211595
92Testicular atrophy (HP:0000029)2.30129965
93Malnutrition (HP:0004395)2.29955276
94Neonatal onset (HP:0003623)2.29704346
95Acanthosis nigricans (HP:0000956)2.28898341
96Cardiovascular calcification (HP:0011915)2.28776960
97Hypertriglyceridemia (HP:0002155)2.26532342
98Pancreatitis (HP:0001733)2.25810998
99Thin bony cortex (HP:0002753)2.24280255
100Opisthotonus (HP:0002179)2.22054160
101Growth hormone excess (HP:0000845)2.21117113
102Vomiting (HP:0002013)2.21058808
103Brushfield spots (HP:0001088)2.20957633
104Hyperinsulinemic hypoglycemia (HP:0000825)2.20501278
105Acanthocytosis (HP:0001927)2.20419837
106Cerebral aneurysm (HP:0004944)2.20299500
107Recurrent gram-negative bacterial infections (HP:0005420)2.20177209
108Wormian bones (HP:0002645)2.20086580
109Aortic regurgitation (HP:0001659)2.18988131
110Aortic dissection (HP:0002647)2.17036654
111Esophageal varix (HP:0002040)2.13982478
112Glycosuria (HP:0003076)2.13433299
113Abnormality of urine glucose concentration (HP:0011016)2.13433299
114Difficulty climbing stairs (HP:0003551)2.13150362
115Abnormality of skeletal muscle fiber size (HP:0012084)2.11961399
116Ulnar bowing (HP:0003031)2.11364305
117Distal upper limb amyotrophy (HP:0007149)2.10402670
118Upper limb amyotrophy (HP:0009129)2.10402670
119Abnormal gallbladder morphology (HP:0012437)2.09837449
120Thrombophlebitis (HP:0004418)2.08562178
121Alkalosis (HP:0001948)2.08451834
122Ileus (HP:0002595)2.08380110
123Sensorimotor neuropathy (HP:0007141)2.08075969
124Hydroxyprolinuria (HP:0003080)2.07985726
125Abnormality of proline metabolism (HP:0010907)2.07985726
126Abnormality of glycolipid metabolism (HP:0010969)2.07014643
127Abnormality of liposaccharide metabolism (HP:0010968)2.07014643
128Abnormality of glycosphingolipid metabolism (HP:0004343)2.07014643
129Spastic diplegia (HP:0001264)2.04343337
130Reduced subcutaneous adipose tissue (HP:0003758)2.04228495
131Abnormality of the distal phalanges of the toes (HP:0010182)2.03754673
132Cholelithiasis (HP:0001081)2.02355769
133Increased connective tissue (HP:0009025)2.01935383
134Mildly elevated creatine phosphokinase (HP:0008180)2.01237053
135Proximal tubulopathy (HP:0000114)2.01109426
136Enlarged kidneys (HP:0000105)1.98908980
137Round ear (HP:0100830)1.98774855
138Interstitial pulmonary disease (HP:0006530)1.98357692
139Broad metatarsal (HP:0001783)1.97685253
140Bronchomalacia (HP:0002780)1.94973307
141Vascular tortuosity (HP:0004948)1.94407592
142Bowed forearm bones (HP:0003956)1.94339520
143Bowing of the arm (HP:0006488)1.94339520
144Stroke (HP:0001297)1.94232034
145Rickets (HP:0002748)1.93390637
146Abnormal enzyme/coenzyme activity (HP:0012379)1.93032820
147Obstructive sleep apnea (HP:0002870)1.91475586
148Trismus (HP:0000211)1.90481152
149Mitral regurgitation (HP:0001653)1.89872167
150Arterial tortuosity (HP:0005116)1.88902123
151Cholecystitis (HP:0001082)1.88654961
152Abnormal gallbladder physiology (HP:0012438)1.88654961
153Elevated hepatic transaminases (HP:0002910)1.88580618
154Short clavicles (HP:0000894)1.86132914
155Blue sclerae (HP:0000592)1.85648631
156Abnormality of iron homeostasis (HP:0011031)1.84998021
157Renal cortical cysts (HP:0000803)1.84958779
158Hemorrhage of the eye (HP:0011885)1.84895705
159Hyperparathyroidism (HP:0000843)1.84538016
160Bradycardia (HP:0001662)1.84095580
161Bladder diverticulum (HP:0000015)1.83618192
162Hyperuricemia (HP:0002149)1.83310611
163Increased purine levels (HP:0004368)1.83310611
164Ankle contracture (HP:0006466)1.82977848
165Abnormality of transition element cation homeostasis (HP:0011030)1.82140721
166Rectal prolapse (HP:0002035)1.81920728
167Aplasia/Hypoplasia of the clavicles (HP:0006710)1.81282663
168Biconcave vertebral bodies (HP:0004586)1.78921824
169Epistaxis (HP:0000421)1.77767570
170Abnormal cartilage morphology (HP:0002763)1.77330487
171Wrist flexion contracture (HP:0001239)1.77210270
172Insulin resistance (HP:0000855)1.76919897
173Polycythemia (HP:0001901)1.76332503
174Aortic valve stenosis (HP:0001650)1.75304819
175Natal tooth (HP:0000695)1.74708486
176Elbow flexion contracture (HP:0002987)1.72923407
177Turricephaly (HP:0000262)1.71918115
178Atrioventricular block (HP:0001678)1.68759618
179Neonatal short-limb short stature (HP:0008921)1.68125090
180Atelectasis (HP:0100750)1.67717005
181Hydroureter (HP:0000072)1.66967031
182Exercise-induced myalgia (HP:0003738)1.66719592
183Asymmetric septal hypertrophy (HP:0001670)1.66715452

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.10754500
2ERN14.46354314
3FGFR44.10935056
4SIK13.84338861
5EPHA23.26702990
6TESK13.22611798
7EPHB22.89353180
8TAOK32.77509747
9TYK22.46460345
10INSRR2.37324676
11FLT32.31802992
12PRKD22.14906095
13TRIB32.07876316
14MAPK151.99131765
15TESK21.98083079
16TTN1.96269518
17ARAF1.95495058
18MST1R1.95246812
19PKN21.93289008
20PIK3CG1.82141487
21TBK11.82106187
22NTRK11.78575697
23MAP3K61.73591222
24MAP2K41.62024636
25LIMK11.58083836
26PTK61.54212216
27KDR1.53283994
28MAPK111.48357336
29ICK1.46697703
30ERBB41.43978284
31NEK91.41144323
32PINK11.33885045
33MAP2K31.28580421
34TGFBR21.27941880
35MAP3K71.27488920
36EPHB11.27451525
37CAMK1D1.26824480
38CDC42BPA1.26350840
39DAPK31.24620961
40MAP4K11.22838267
41JAK11.19968183
42PDGFRA1.19770037
43IRAK31.19277860
44KIT1.18698848
45MAP3K141.18109152
46MAPKAPK31.16543712
47ILK1.16455342
48TLK11.15652867
49IKBKE1.15580056
50JAK21.14744466
51ABL21.14199171
52MARK21.11890470
53TAOK11.11112166
54NME21.08913708
55ZAP701.08799951
56PAK41.07740351
57RPS6KA21.03002469
58CSK1.01687521
59BTK1.00119244
60MAPK40.99873434
61TIE10.98429098
62LMTK20.98414716
63MAP3K110.97760855
64SMG10.95028576
65PRKAA20.94807477
66STK380.93184889
67DDR20.91223144
68EPHA30.89790140
69CSF1R0.88910910
70MAP2K60.88344304
71PAK20.86003036
72MAP2K20.85129386
73GRK60.84965600
74NME10.84860523
75MAP3K100.84569577
76DMPK0.83372399
77BLK0.82989149
78MAP3K30.82137085
79MATK0.78004791
80PRKD10.77824949
81DAPK20.77820345
82PRKD30.77284449
83PDPK10.76137735
84MOS0.75689895
85CAMK1G0.74639697
86JAK30.74510860
87RIPK10.73254493
88PRKG20.73219894
89TAOK20.73141022
90MTOR0.72471597
91LATS20.72276441
92IKBKB0.71956368
93TEC0.69538252
94ITK0.67083651
95PRKCZ0.67050979
96BMX0.66426466
97DYRK1B0.66061166
98RPS6KC10.65929481
99RPS6KL10.65929481
100ROCK10.65893595
101PRPF4B0.64932106
102SYK0.61806490
103MAPK120.61410290
104ERBB20.61283206
105PRKACG0.60633057
106FRK0.60136142
107AURKA0.59278962
108PDK10.58978185
109GSK3A0.56766828
110MAP3K130.56480271
111PTK20.56229357
112HIPK20.56031050
113IRAK40.54389387
114FGFR30.54343720
115LRRK20.50824239
116MYLK0.50418626
117MAP4K20.50020044
118CAMK40.49850086
119BRAF0.49782963
120MAPK70.49681463
121RPS6KA60.49501968
122CSNK1G10.48889384
123PAK10.48252861
124ADRBK20.47218582
125LYN0.46628391
126CAMK2G0.46060344
127CDK80.46041440
128PRKCI0.44886704
129CDK60.44443939
130RET0.44124303
131ADRBK10.43702708
132CAMK2D0.42787080
133PRKAA10.42459099
134TXK0.41959690
135IGF1R0.40643536
136SIK20.39999339
137IRAK10.39781559
138PRKCQ0.38388628
139CHUK0.38286000
140MAP3K10.37509435
141CDK90.37087660
142PAK60.37022111
143GRK10.36579673
144GRK50.36345615
145SIK30.36073362
146PIM20.34921596
147CSNK1G30.34874850
148SRC0.34641603
149PIK3CA0.33652897
150ROCK20.33646152
151PHKG20.32466126
152PHKG10.32466126
153MET0.32369981
154MAPK30.31437822
155AKT20.30492113
156MAP2K10.30082888
157CAMKK20.29808554
158MAP3K50.29802600
159PIM10.28680796
160PKN10.28221713

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.26780786
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.56260458
3Nitrogen metabolism_Homo sapiens_hsa009103.35683003
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86735176
5Arginine biosynthesis_Homo sapiens_hsa002202.79650628
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.73981356
7Tryptophan metabolism_Homo sapiens_hsa003802.69037401
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.57275403
9Complement and coagulation cascades_Homo sapiens_hsa046102.56660463
10Fatty acid degradation_Homo sapiens_hsa000712.51935203
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46264225
12* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45083905
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33937779
14Peroxisome_Homo sapiens_hsa041462.22397714
15Butanoate metabolism_Homo sapiens_hsa006502.21386648
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13653474
17Histidine metabolism_Homo sapiens_hsa003402.00105528
18Chemical carcinogenesis_Homo sapiens_hsa052041.97460045
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.93946840
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.92550754
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91949310
22Propanoate metabolism_Homo sapiens_hsa006401.90304624
23ECM-receptor interaction_Homo sapiens_hsa045121.89927143
24PPAR signaling pathway_Homo sapiens_hsa033201.85920020
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.84165467
26Staphylococcus aureus infection_Homo sapiens_hsa051501.78687076
27Fatty acid metabolism_Homo sapiens_hsa012121.76875422
28Sulfur metabolism_Homo sapiens_hsa009201.73868480
29beta-Alanine metabolism_Homo sapiens_hsa004101.73654446
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72816100
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69209560
32Retinol metabolism_Homo sapiens_hsa008301.67911150
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62032348
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60905367
35Caffeine metabolism_Homo sapiens_hsa002321.58812635
36Selenocompound metabolism_Homo sapiens_hsa004501.56728115
37Notch signaling pathway_Homo sapiens_hsa043301.56517452
38Phenylalanine metabolism_Homo sapiens_hsa003601.50047256
39Bile secretion_Homo sapiens_hsa049761.48461233
40Folate biosynthesis_Homo sapiens_hsa007901.47286812
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42675376
42Fatty acid elongation_Homo sapiens_hsa000621.40850562
43Protein digestion and absorption_Homo sapiens_hsa049741.39600599
44Pyruvate metabolism_Homo sapiens_hsa006201.37287468
45Starch and sucrose metabolism_Homo sapiens_hsa005001.36897604
46Tyrosine metabolism_Homo sapiens_hsa003501.35708753
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32810951
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.32056084
49ABC transporters_Homo sapiens_hsa020101.28699799
50Focal adhesion_Homo sapiens_hsa045101.25220809
51Sulfur relay system_Homo sapiens_hsa041221.24760941
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.15473433
53Fat digestion and absorption_Homo sapiens_hsa049751.14940749
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14447914
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.11967369
56Carbon metabolism_Homo sapiens_hsa012001.05258973
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04918275
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01971992
59Steroid biosynthesis_Homo sapiens_hsa001001.01785719
60Dilated cardiomyopathy_Homo sapiens_hsa054141.00200611
61Biosynthesis of amino acids_Homo sapiens_hsa012300.99580534
62Bladder cancer_Homo sapiens_hsa052190.99572695
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98392175
64Sphingolipid metabolism_Homo sapiens_hsa006000.98092383
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92330376
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92090554
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91613766
68Arginine and proline metabolism_Homo sapiens_hsa003300.91485129
69Vitamin digestion and absorption_Homo sapiens_hsa049770.90987096
70Ribosome_Homo sapiens_hsa030100.86230135
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81728906
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79786438
73Lysine degradation_Homo sapiens_hsa003100.77110545
74Amoebiasis_Homo sapiens_hsa051460.73917094
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72425535
76Glycerolipid metabolism_Homo sapiens_hsa005610.72015010
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68376410
78Glutathione metabolism_Homo sapiens_hsa004800.67802938
79Vibrio cholerae infection_Homo sapiens_hsa051100.66969710
80Salmonella infection_Homo sapiens_hsa051320.64340153
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63091889
82Vitamin B6 metabolism_Homo sapiens_hsa007500.62180639
83Pentose phosphate pathway_Homo sapiens_hsa000300.61165500
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60936614
85Endocytosis_Homo sapiens_hsa041440.60033553
86Mineral absorption_Homo sapiens_hsa049780.55612926
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.54969290
88One carbon pool by folate_Homo sapiens_hsa006700.53907330
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52547514
90Tight junction_Homo sapiens_hsa045300.50439041
91* Metabolic pathways_Homo sapiens_hsa011000.50287748
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.46000193
93VEGF signaling pathway_Homo sapiens_hsa043700.45768783
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45744721
95Cocaine addiction_Homo sapiens_hsa050300.45432502
96Galactose metabolism_Homo sapiens_hsa000520.43811654
97Small cell lung cancer_Homo sapiens_hsa052220.42488083
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.39970665
99Chronic myeloid leukemia_Homo sapiens_hsa052200.38596310
100Fructose and mannose metabolism_Homo sapiens_hsa000510.37953922
101Shigellosis_Homo sapiens_hsa051310.37752462
102GnRH signaling pathway_Homo sapiens_hsa049120.36406496
103Renin secretion_Homo sapiens_hsa049240.34162978
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32880285
105Insulin resistance_Homo sapiens_hsa049310.29220244
106Prion diseases_Homo sapiens_hsa050200.28984390
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.28080130
108Fatty acid biosynthesis_Homo sapiens_hsa000610.25636400
109Linoleic acid metabolism_Homo sapiens_hsa005910.24887842
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21444645
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10474385
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.10314561
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.09292573
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.07513379
115Glucagon signaling pathway_Homo sapiens_hsa049220.04685931
116Renin-angiotensin system_Homo sapiens_hsa04614-0.1886843
117Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1824634
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1706165
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1673775
120African trypanosomiasis_Homo sapiens_hsa05143-0.1628694
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1458638
122Oxidative phosphorylation_Homo sapiens_hsa00190-0.1428803
123Insulin signaling pathway_Homo sapiens_hsa04910-0.1285903
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1149920
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1131530
126Pertussis_Homo sapiens_hsa05133-0.1017417
127Hepatitis C_Homo sapiens_hsa05160-0.0996491
128Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0849566
129Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0845188
130Regulation of autophagy_Homo sapiens_hsa04140-0.0711092
131Lysosome_Homo sapiens_hsa04142-0.0567794
132AMPK signaling pathway_Homo sapiens_hsa04152-0.0132626
133Other glycan degradation_Homo sapiens_hsa00511-0.0112940
134Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0061879

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