HYKK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.32564794
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.32564794
3L-phenylalanine metabolic process (GO:0006558)6.95834044
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.95834044
5aromatic amino acid family catabolic process (GO:0009074)6.91719247
6indole-containing compound catabolic process (GO:0042436)6.56135466
7indolalkylamine catabolic process (GO:0046218)6.56135466
8tryptophan catabolic process (GO:0006569)6.56135466
9glyoxylate metabolic process (GO:0046487)6.21303966
10tryptophan metabolic process (GO:0006568)6.18459841
11kynurenine metabolic process (GO:0070189)5.84269082
12cysteine metabolic process (GO:0006534)5.70232949
13bile acid biosynthetic process (GO:0006699)5.54748662
14serine family amino acid catabolic process (GO:0009071)5.35366232
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.34603955
16amino-acid betaine metabolic process (GO:0006577)5.26962159
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.26062946
18drug transmembrane transport (GO:0006855)5.21651638
19urate metabolic process (GO:0046415)5.20233156
20lysine catabolic process (GO:0006554)5.10229152
21lysine metabolic process (GO:0006553)5.10229152
22homocysteine metabolic process (GO:0050667)5.07074749
23aromatic amino acid family metabolic process (GO:0009072)5.03041078
24urea metabolic process (GO:0019627)4.89778380
25urea cycle (GO:0000050)4.89778380
26drug catabolic process (GO:0042737)4.89362907
27amine catabolic process (GO:0009310)4.83034297
28cellular biogenic amine catabolic process (GO:0042402)4.83034297
29sulfur amino acid catabolic process (GO:0000098)4.81470334
30alpha-linolenic acid metabolic process (GO:0036109)4.77456647
31behavioral response to nicotine (GO:0035095)4.77353047
32indolalkylamine metabolic process (GO:0006586)4.73788642
33high-density lipoprotein particle remodeling (GO:0034375)4.72741446
34bile acid metabolic process (GO:0008206)4.71133053
35alpha-amino acid catabolic process (GO:1901606)4.68745588
36peptidyl-glutamic acid carboxylation (GO:0017187)4.60053432
37protein carboxylation (GO:0018214)4.60053432
38tyrosine metabolic process (GO:0006570)4.54270263
39nitrogen cycle metabolic process (GO:0071941)4.53674679
40cellular glucuronidation (GO:0052695)4.51846001
41fucose catabolic process (GO:0019317)4.48151950
42L-fucose metabolic process (GO:0042354)4.48151950
43L-fucose catabolic process (GO:0042355)4.48151950
44regulation of fibrinolysis (GO:0051917)4.45745867
45regulation of cholesterol esterification (GO:0010872)4.45566913
46negative regulation of fibrinolysis (GO:0051918)4.43278150
47exogenous drug catabolic process (GO:0042738)4.43278066
48cellular ketone body metabolic process (GO:0046950)4.38912848
49serine family amino acid metabolic process (GO:0009069)4.37982445
50cellular amino acid catabolic process (GO:0009063)4.33916291
51drug transport (GO:0015893)4.33282499
52short-chain fatty acid metabolic process (GO:0046459)4.30258346
53regulation of protein activation cascade (GO:2000257)4.29526487
54complement activation, alternative pathway (GO:0006957)4.28859161
55carnitine metabolic process (GO:0009437)4.27586789
56uronic acid metabolic process (GO:0006063)4.25253097
57glucuronate metabolic process (GO:0019585)4.25253097
58DNA deamination (GO:0045006)4.24889419
59benzene-containing compound metabolic process (GO:0042537)4.23336460
60cellular modified amino acid catabolic process (GO:0042219)4.20564484
61detection of light stimulus involved in sensory perception (GO:0050962)4.18040320
62detection of light stimulus involved in visual perception (GO:0050908)4.18040320
63coenzyme catabolic process (GO:0009109)4.16952269
64protein-lipid complex remodeling (GO:0034368)4.16174717
65macromolecular complex remodeling (GO:0034367)4.16174717
66plasma lipoprotein particle remodeling (GO:0034369)4.16174717
67reverse cholesterol transport (GO:0043691)4.12621847
68regulation of triglyceride catabolic process (GO:0010896)4.09226105
69aldehyde catabolic process (GO:0046185)4.08790479
70acylglycerol homeostasis (GO:0055090)4.08663725
71triglyceride homeostasis (GO:0070328)4.08663725
72glutamate metabolic process (GO:0006536)4.07675623
73regulation of complement activation (GO:0030449)3.98479375
74glycine metabolic process (GO:0006544)3.96858706
75negative regulation of cholesterol transport (GO:0032375)3.95620281
76negative regulation of sterol transport (GO:0032372)3.95620281
77bile acid and bile salt transport (GO:0015721)3.93180381
78imidazole-containing compound metabolic process (GO:0052803)3.92944868
79ethanol oxidation (GO:0006069)3.92495286
80serine family amino acid biosynthetic process (GO:0009070)3.92341323
81phospholipid efflux (GO:0033700)3.90756516
82NAD biosynthetic process (GO:0009435)3.89680406
83water-soluble vitamin biosynthetic process (GO:0042364)3.88752879
84organic acid catabolic process (GO:0016054)3.88208226
85carboxylic acid catabolic process (GO:0046395)3.88208226
86regulation of bile acid biosynthetic process (GO:0070857)3.84313873
87low-density lipoprotein particle remodeling (GO:0034374)3.82607175
88ketone body metabolic process (GO:1902224)3.77829648
89nicotinamide nucleotide biosynthetic process (GO:0019359)3.76599569
90pyridine nucleotide biosynthetic process (GO:0019363)3.76599569
91fatty acid beta-oxidation (GO:0006635)3.69332030
92aspartate family amino acid catabolic process (GO:0009068)3.68809982
93dicarboxylic acid biosynthetic process (GO:0043650)3.68439818
94acetyl-CoA metabolic process (GO:0006084)3.68166530
95fatty acid oxidation (GO:0019395)3.65954588
96lipid oxidation (GO:0034440)3.62234354
97arginine metabolic process (GO:0006525)3.61672002
98cholesterol efflux (GO:0033344)3.58459605
99monocarboxylic acid catabolic process (GO:0072329)3.58338638
100detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.57064319
101plasma lipoprotein particle clearance (GO:0034381)3.50337141
102flavonoid metabolic process (GO:0009812)3.48169037
103fatty acid catabolic process (GO:0009062)3.46451484
104indole-containing compound metabolic process (GO:0042430)3.45635269
105negative regulation of lipase activity (GO:0060192)3.44512797
106drug metabolic process (GO:0017144)3.44449196
107regulation of hippo signaling (GO:0035330)3.43875616
108valine metabolic process (GO:0006573)3.41918200
109branched-chain amino acid catabolic process (GO:0009083)3.41902743
1102-oxoglutarate metabolic process (GO:0006103)3.40167862
111neuronal action potential (GO:0019228)3.36427401
112oxidative demethylation (GO:0070989)3.30613004
113sulfation (GO:0051923)3.28699774
114response to pheromone (GO:0019236)3.17302546
115respiratory chain complex IV assembly (GO:0008535)3.16199092
116primary amino compound metabolic process (GO:1901160)3.15379360
117preassembly of GPI anchor in ER membrane (GO:0016254)3.13025300
118positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.11589944
119protein polyglutamylation (GO:0018095)3.09428498
120serotonin metabolic process (GO:0042428)3.01038619
121axoneme assembly (GO:0035082)2.97030747
122gamma-aminobutyric acid transport (GO:0015812)2.95427443
123reflex (GO:0060004)2.92050418
124cAMP catabolic process (GO:0006198)2.91776853
125multicellular organism reproduction (GO:0032504)2.91688870
126mitochondrial respiratory chain complex I assembly (GO:0032981)2.90080021
127NADH dehydrogenase complex assembly (GO:0010257)2.90080021
128mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.90080021
129protein complex biogenesis (GO:0070271)2.89671492
130epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89398332
131piRNA metabolic process (GO:0034587)2.86543367
132nonmotile primary cilium assembly (GO:0035058)2.84737154
133cellular response to ATP (GO:0071318)2.82893347
134positive regulation of fatty acid transport (GO:2000193)2.82748610
135reciprocal meiotic recombination (GO:0007131)2.82494270
136reciprocal DNA recombination (GO:0035825)2.82494270
137neural tube formation (GO:0001841)2.80040901
138signal peptide processing (GO:0006465)2.78210547
139cytochrome complex assembly (GO:0017004)2.77867734
140regulation of hexokinase activity (GO:1903299)2.75033794
141regulation of glucokinase activity (GO:0033131)2.75033794
142regulation of mesoderm development (GO:2000380)2.74932479
143phosphatidylinositol acyl-chain remodeling (GO:0036149)2.73477053
144platelet dense granule organization (GO:0060155)2.71092982
145L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70881879
146negative regulation of mast cell activation (GO:0033004)2.70449086
147negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70179540
148behavioral response to ethanol (GO:0048149)2.69985627
149cyclic nucleotide catabolic process (GO:0009214)2.69400545
150regulation of gene silencing by RNA (GO:0060966)2.68173479
151regulation of posttranscriptional gene silencing (GO:0060147)2.68173479
152regulation of gene silencing by miRNA (GO:0060964)2.68173479
153mitochondrial respiratory chain complex assembly (GO:0033108)2.67656157
154photoreceptor cell maintenance (GO:0045494)2.67566104
155auditory receptor cell stereocilium organization (GO:0060088)2.65842424
156retinal cone cell development (GO:0046549)2.65263441
157membrane depolarization during action potential (GO:0086010)2.65060635
158DNA methylation involved in gamete generation (GO:0043046)2.64750346
159kidney morphogenesis (GO:0060993)2.62585583
160mannosylation (GO:0097502)2.58815239
161protein-cofactor linkage (GO:0018065)2.57293830
162protein K11-linked deubiquitination (GO:0035871)2.55943753
163regulation of action potential (GO:0098900)2.55905401
164thyroid hormone metabolic process (GO:0042403)2.55261231
165negative regulation of transcription regulatory region DNA binding (GO:2000678)2.53644838
166protein localization to cilium (GO:0061512)2.52509330
167RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.52007609
168rhodopsin mediated signaling pathway (GO:0016056)2.50672143
169cornea development in camera-type eye (GO:0061303)2.50179288
170regulation of rhodopsin mediated signaling pathway (GO:0022400)2.49134363
171amino acid salvage (GO:0043102)2.49009718
172L-methionine salvage (GO:0071267)2.49009718
173L-methionine biosynthetic process (GO:0071265)2.49009718
174recombinational repair (GO:0000725)2.47959057
175double-strand break repair via homologous recombination (GO:0000724)2.47567435
176epithelial cilium movement (GO:0003351)2.45144829
177cilium morphogenesis (GO:0060271)2.43970095
178alkaloid metabolic process (GO:0009820)2.43644117
179somite development (GO:0061053)2.40843254
180purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.40686332
1813-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.40686332
182cilium organization (GO:0044782)2.39889586
183interkinetic nuclear migration (GO:0022027)2.39784862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.28798095
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.58729539
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.06749942
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.69778152
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.57688483
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.22083384
7ZNF274_21170338_ChIP-Seq_K562_Hela3.65168898
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.61994170
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.46170037
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.38765926
11IGF1R_20145208_ChIP-Seq_DFB_Human2.45089059
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41390255
13EWS_26573619_Chip-Seq_HEK293_Human2.18092195
14FUS_26573619_Chip-Seq_HEK293_Human2.13685005
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.13455409
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01955644
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0299755
18ER_23166858_ChIP-Seq_MCF-7_Human1.99131814
19EZH2_22144423_ChIP-Seq_EOC_Human1.95582218
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88387155
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83138426
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.82468663
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77520674
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76592053
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.76524817
26STAT3_23295773_ChIP-Seq_U87_Human1.69884707
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67428517
28SMAD4_21799915_ChIP-Seq_A2780_Human1.58983081
29TCF4_23295773_ChIP-Seq_U87_Human1.57173116
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52603974
31CBP_20019798_ChIP-Seq_JUKART_Human1.52603974
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51763964
33TP53_22573176_ChIP-Seq_HFKS_Human1.51152928
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45882697
35HTT_18923047_ChIP-ChIP_STHdh_Human1.44862161
36AR_25329375_ChIP-Seq_VCAP_Human1.43460005
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.43067112
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42301271
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39991949
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38942049
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37854287
42GBX2_23144817_ChIP-Seq_PC3_Human1.37619780
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37442895
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.36842562
45HNF4A_19822575_ChIP-Seq_HepG2_Human1.35449288
46SOX2_19829295_ChIP-Seq_ESCs_Human1.34087594
47NANOG_19829295_ChIP-Seq_ESCs_Human1.34087594
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31807911
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30462774
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30462774
51FLI1_21867929_ChIP-Seq_TH2_Mouse1.28078912
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.28023530
53TCF4_22108803_ChIP-Seq_LS180_Human1.27881619
54KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26636391
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26532781
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26292281
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.26292281
58REST_21632747_ChIP-Seq_MESCs_Mouse1.24142376
59RUNX2_22187159_ChIP-Seq_PCA_Human1.24037176
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.22595258
61SMAD4_21741376_ChIP-Seq_EPCs_Human1.22032625
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21466514
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20688034
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.18283940
65RNF2_27304074_Chip-Seq_NSC_Mouse1.16574599
66NCOR_22424771_ChIP-Seq_293T_Human1.15389858
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14721839
68KAP1_22055183_ChIP-Seq_ESCs_Mouse1.14417266
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13979243
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13715531
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12981346
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12016725
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.11195427
74TAF15_26573619_Chip-Seq_HEK293_Human1.10824803
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.10571585
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.10470727
77MYC_18940864_ChIP-ChIP_HL60_Human1.09841234
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09191127
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08976608
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.07492009
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.06792004
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06658167
83HOXB7_26014856_ChIP-Seq_BT474_Human1.06021074
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05982580
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05775650
86VDR_22108803_ChIP-Seq_LS180_Human1.05723633
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04572177
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04230940
89IRF1_19129219_ChIP-ChIP_H3396_Human1.04027228
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01522181
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99898702
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98645242
93RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97771851
94ARNT_22903824_ChIP-Seq_MCF-7_Human0.97527180
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97439738
96AR_21572438_ChIP-Seq_LNCaP_Human0.97409398
97KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97017073
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.96794401
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95513107
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94982741
101NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93617762
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93617762
103ESR1_21235772_ChIP-Seq_MCF-7_Human0.92690054
104SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90777329
105ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88595308
106ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87816355
107CRX_20693478_ChIP-Seq_RETINA_Mouse0.87305177
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87188644
109IRF8_22096565_ChIP-ChIP_GC-B_Human0.86862162
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86508131
111STAT1_17558387_ChIP-Seq_HELA_Human0.85812417
112PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85727967
113RUNX1_27457419_Chip-Seq_LIVER_Mouse0.85528962
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85380546
115OCT4_21477851_ChIP-Seq_ESCs_Mouse0.85338187
116GATA4_25053715_ChIP-Seq_YYC3_Human0.83512366
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83184494
118AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82902340
119FLI1_27457419_Chip-Seq_LIVER_Mouse0.82784735
120BCAT_22108803_ChIP-Seq_LS180_Human0.78952030
121P300_19829295_ChIP-Seq_ESCs_Human0.77661004
122GATA1_22025678_ChIP-Seq_K562_Human0.76684006
123AR_20517297_ChIP-Seq_VCAP_Human0.76485148
124EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.75883868
125ESRRB_18555785_Chip-Seq_ESCs_Mouse0.74868990
126PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74359419
127CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.74273783
128OCT4_18555785_Chip-Seq_ESCs_Mouse0.74119205
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72959080
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.72953542
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.72015381
132CDX2_22108803_ChIP-Seq_LS180_Human0.71864614
133TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71520890
134SMAD1_18555785_Chip-Seq_ESCs_Mouse0.70311858
135SUZ12_18555785_Chip-Seq_ESCs_Mouse0.69726532
136P53_22387025_ChIP-Seq_ESCs_Mouse0.69543350
137CDX2_19796622_ChIP-Seq_MESCs_Mouse0.69157941
138SOX2_27498859_Chip-Seq_STOMACH_Mouse0.68873292
139P300_18555785_Chip-Seq_ESCs_Mouse0.68833356
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68799469
141THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.68582963
142CBP_21632823_ChIP-Seq_H3396_Human0.67698562
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.67693218
144PU1_27457419_Chip-Seq_LIVER_Mouse0.67531753
145PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.67314142
146STAT3_18555785_Chip-Seq_ESCs_Mouse0.67217408
147BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66714757
148CLOCK_20551151_ChIP-Seq_293T_Human0.65403978
149TAL1_26923725_Chip-Seq_HPCs_Mouse0.64764310
150ZFX_18555785_Chip-Seq_ESCs_Mouse0.64232669
151KLF4_18555785_Chip-Seq_ESCs_Mouse0.63397971
152SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63367384
153KDM2B_26808549_Chip-Seq_REH_Human0.62212598
154NMYC_18555785_Chip-Seq_ESCs_Mouse0.62192705
155SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.61907498
156E2F1_18555785_Chip-Seq_ESCs_Mouse0.60686771
157SOX2_18555785_Chip-Seq_ESCs_Mouse0.60121397
158PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.59986636
159ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.59414458
160POU3F2_20337985_ChIP-ChIP_501MEL_Human0.59137298
161FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.59099650
162NANOG_18555785_Chip-Seq_ESCs_Mouse0.59055077
163TP53_18474530_ChIP-ChIP_U2OS_Human0.58848927
164NR3C1_21868756_ChIP-Seq_MCF10A_Human0.58584944

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.18465260
2MP0005360_urolithiasis7.77220194
3MP0005085_abnormal_gallbladder_physiolo5.97927082
4MP0005365_abnormal_bile_salt5.69639621
5MP0008875_abnormal_xenobiotic_pharmacok4.97539577
6MP0003252_abnormal_bile_duct3.96381650
7MP0003646_muscle_fatigue3.50825465
8MP0003195_calcinosis3.45896943
9MP0003806_abnormal_nucleotide_metabolis3.43426707
10MP0005332_abnormal_amino_acid3.36382659
11MP0004019_abnormal_vitamin_homeostasis3.12080029
12MP0000569_abnormal_digit_pigmentation3.06292911
13MP0010329_abnormal_lipoprotein_level3.02232158
14MP0002138_abnormal_hepatobiliary_system2.85493553
15MP0001968_abnormal_touch/_nociception2.73978015
16MP0002736_abnormal_nociception_after2.57813011
17MP0005083_abnormal_biliary_tract2.51423087
18MP0005551_abnormal_eye_electrophysiolog2.50399005
19MP0008877_abnormal_DNA_methylation2.48478013
20MP0009840_abnormal_foam_cell2.47285164
21MP0002837_dystrophic_cardiac_calcinosis2.32277048
22MP0002102_abnormal_ear_morphology2.32057937
23MP0001666_abnormal_nutrient_absorption2.25987438
24MP0009046_muscle_twitch2.21672146
25MP0000372_irregular_coat_pigmentation1.85952586
26MP0003136_yellow_coat_color1.83965500
27MP0002118_abnormal_lipid_homeostasis1.83449157
28MP0001501_abnormal_sleep_pattern1.82760567
29MP0009643_abnormal_urine_homeostasis1.79188977
30MP0001986_abnormal_taste_sensitivity1.76965563
31MP0002653_abnormal_ependyma_morphology1.76685806
32MP0000609_abnormal_liver_physiology1.76102376
33MP0001764_abnormal_homeostasis1.74306418
34MP0003191_abnormal_cellular_cholesterol1.74179227
35MP0009745_abnormal_behavioral_response1.73600519
36MP0005451_abnormal_body_composition1.73329328
37MP0005174_abnormal_tail_pigmentation1.72460248
38MP0001485_abnormal_pinna_reflex1.68029957
39MP0005253_abnormal_eye_physiology1.67174404
40MP0005319_abnormal_enzyme/_coenzyme1.63259881
41MP0002876_abnormal_thyroid_physiology1.62489441
42MP0006072_abnormal_retinal_apoptosis1.61456531
43MP0002272_abnormal_nervous_system1.60486716
44MP0006292_abnormal_olfactory_placode1.59144186
45MP0002938_white_spotting1.58600733
46MP0004043_abnormal_pH_regulation1.58108561
47MP0004142_abnormal_muscle_tone1.57013700
48MP0009697_abnormal_copulation1.54616699
49MP0003868_abnormal_feces_composition1.52949098
50MP0000427_abnormal_hair_cycle1.52484423
51MP0003186_abnormal_redox_activity1.51773530
52MP0005584_abnormal_enzyme/coenzyme_acti1.51450974
53MP0005645_abnormal_hypothalamus_physiol1.49285823
54MP0005636_abnormal_mineral_homeostasis1.46527523
55MP0003011_delayed_dark_adaptation1.42341758
56MP0003787_abnormal_imprinting1.41285471
57MP0000631_abnormal_neuroendocrine_gland1.39638055
58MP0004145_abnormal_muscle_electrophysio1.38517713
59MP0006276_abnormal_autonomic_nervous1.35500302
60MP0009764_decreased_sensitivity_to1.28535495
61MP0004885_abnormal_endolymph1.28500169
62MP0002638_abnormal_pupillary_reflex1.27526477
63MP0005670_abnormal_white_adipose1.26767659
64MP0004133_heterotaxia1.25258002
65MP0005084_abnormal_gallbladder_morpholo1.22915234
66MP0002735_abnormal_chemical_nociception1.22585130
67MP0005647_abnormal_sex_gland1.19256504
68MP0000383_abnormal_hair_follicle1.19125624
69MP0002163_abnormal_gland_morphology1.17449681
70MP0004742_abnormal_vestibular_system1.17194902
71MP0002064_seizures1.11661687
72MP0000566_synostosis1.10538658
73MP0002234_abnormal_pharynx_morphology1.10337327
74MP0002277_abnormal_respiratory_mucosa1.08745953
75MP0001756_abnormal_urination1.08676085
76MP0002160_abnormal_reproductive_system1.08064282
77MP0001984_abnormal_olfaction1.07968678
78MP0004215_abnormal_myocardial_fiber1.07901918
79MP0010386_abnormal_urinary_bladder1.07733858
80MP0002557_abnormal_social/conspecific_i1.06613010
81MP0005389_reproductive_system_phenotype1.06368680
82MP0002572_abnormal_emotion/affect_behav1.06049081
83MP0001486_abnormal_startle_reflex1.05776603
84MP0005075_abnormal_melanosome_morpholog1.05771851
85MP0001970_abnormal_pain_threshold1.05010072
86MP0005379_endocrine/exocrine_gland_phen1.01283195
87MP0000015_abnormal_ear_pigmentation0.98919608
88MP0005410_abnormal_fertilization0.97620358
89MP0002136_abnormal_kidney_physiology0.97405458
90MP0002734_abnormal_mechanical_nocicepti0.97278806
91MP0002909_abnormal_adrenal_gland0.94799506
92MP0004924_abnormal_behavior0.94583107
93MP0005386_behavior/neurological_phenoty0.94583107
94MP0002095_abnormal_skin_pigmentation0.94388599
95MP0005195_abnormal_posterior_eye0.92995432
96MP0008775_abnormal_heart_ventricle0.92687361
97MP0005408_hypopigmentation0.92586830
98MP0001765_abnormal_ion_homeostasis0.91536344
99MP0002733_abnormal_thermal_nociception0.91460585
100MP0001502_abnormal_circadian_rhythm0.90126699
101MP0000598_abnormal_liver_morphology0.89533281
102MP0002928_abnormal_bile_duct0.88580399
103MP0002067_abnormal_sensory_capabilities0.86555040
104MP0002693_abnormal_pancreas_physiology0.85331272
105MP0009642_abnormal_blood_homeostasis0.84471487
106MP0002254_reproductive_system_inflammat0.81792096
107MP0004381_abnormal_hair_follicle0.81170592
108MP0009763_increased_sensitivity_to0.79472395
109MP0008469_abnormal_protein_level0.79044137
110MP0001661_extended_life_span0.78832815
111MP0001963_abnormal_hearing_physiology0.77348332
112MP0002229_neurodegeneration0.77250164
113MP0006036_abnormal_mitochondrial_physio0.76457180
114MP0000516_abnormal_urinary_system0.76111340
115MP0005367_renal/urinary_system_phenotyp0.76111340
116MP0003698_abnormal_male_reproductive0.75615559
117MP0005535_abnormal_body_temperature0.75012802
118MP0003137_abnormal_impulse_conducting0.74648742
119MP0008058_abnormal_DNA_repair0.73727359
120MP0005395_other_phenotype0.72799336
121MP0003690_abnormal_glial_cell0.72640937
122MP0003724_increased_susceptibility_to0.72232634
123MP0004085_abnormal_heartbeat0.72191193
124MP0005220_abnormal_exocrine_pancreas0.72141994
125MP0002752_abnormal_somatic_nervous0.71501730
126MP0001905_abnormal_dopamine_level0.71100920
127MP0002063_abnormal_learning/memory/cond0.70842771
128MP0003718_maternal_effect0.70770428
129MP0003119_abnormal_digestive_system0.70053774
130MP0003635_abnormal_synaptic_transmissio0.70033680
131MP0009765_abnormal_xenobiotic_induced0.70005101
132MP0005646_abnormal_pituitary_gland0.67073148
133MP0009384_cardiac_valve_regurgitation0.65804940
134MP0005376_homeostasis/metabolism_phenot0.65720036
135MP0004782_abnormal_surfactant_physiolog0.65504899
136MP0002078_abnormal_glucose_homeostasis0.64828758
137MP0002132_abnormal_respiratory_system0.64151071
138MP0010368_abnormal_lymphatic_system0.63056161
139MP0005334_abnormal_fat_pad0.60438759
140MP0003656_abnormal_erythrocyte_physiolo0.60359512
141MP0002168_other_aberrant_phenotype0.59572761
142MP0000230_abnormal_systemic_arterial0.57116961
143MP0000538_abnormal_urinary_bladder0.55034594
144MP0002971_abnormal_brown_adipose0.51882247
145MP0003878_abnormal_ear_physiology0.51344087
146MP0005377_hearing/vestibular/ear_phenot0.51344087
147MP0009053_abnormal_anal_canal0.49956387
148MP0003638_abnormal_response/metabolism_0.47884785
149MP0000604_amyloidosis0.47394494
150MP0003953_abnormal_hormone_level0.44351871
151MP0000579_abnormal_nail_morphology0.44020669
152MP0006035_abnormal_mitochondrial_morpho0.42626833
153MP0005248_abnormal_Harderian_gland0.42600037
154MP0005266_abnormal_metabolism0.38988818
155MP0004147_increased_porphyrin_level0.38612106
156MP0009780_abnormal_chondrocyte_physiolo0.38479106
157MP0000639_abnormal_adrenal_gland0.37890113
158MP0002135_abnormal_kidney_morphology0.35052454
159MP0005448_abnormal_energy_balance0.34407570
160MP0009672_abnormal_birth_weight0.30875087
161MP0001853_heart_inflammation0.30642818
162MP0005595_abnormal_vascular_smooth0.29650714
163MP0002249_abnormal_larynx_morphology0.29395756
164MP0002796_impaired_skin_barrier0.29361186
165MP0008874_decreased_physiological_sensi0.28636829
166MP0005666_abnormal_adipose_tissue0.26515349
167MP0001324_abnormal_eye_pigmentation0.25839598
168MP0002822_catalepsy0.25259771
169MP0009115_abnormal_fat_cell0.25166596
170MP0001542_abnormal_bone_strength0.24803120
171MP0008872_abnormal_physiological_respon0.24279924
172MP0005058_abnormal_lysosome_morphology0.24010858
173MP0005464_abnormal_platelet_physiology0.23655300
174MP0006082_CNS_inflammation0.23347376
175MP0008260_abnormal_autophagy0.22929359
176MP0001177_atelectasis0.22620446

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.47759016
2Intrahepatic cholestasis (HP:0001406)6.32602333
3Prolonged partial thromboplastin time (HP:0003645)5.60193541
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.54030729
5Deep venous thrombosis (HP:0002625)5.52826088
6Xanthomatosis (HP:0000991)5.30963549
7Hyperglycinuria (HP:0003108)4.94066285
8Hypobetalipoproteinemia (HP:0003563)4.76902595
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.75909604
10Hyperlipoproteinemia (HP:0010980)4.63108815
11Hyperglycinemia (HP:0002154)4.54237377
12Abnormality of aspartate family amino acid metabolism (HP:0010899)4.53831515
13Abnormality of glycine metabolism (HP:0010895)4.49486564
14Abnormality of serine family amino acid metabolism (HP:0010894)4.49486564
15Joint hemorrhage (HP:0005261)4.49368584
16Pancreatic cysts (HP:0001737)4.44430727
17Ketosis (HP:0001946)4.26493680
18Hyperammonemia (HP:0001987)4.24179512
19Pancreatic fibrosis (HP:0100732)4.21822719
20Congenital stationary night blindness (HP:0007642)4.15873445
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.10521049
22Complement deficiency (HP:0004431)3.97701841
23Molar tooth sign on MRI (HP:0002419)3.93774701
24Abnormality of midbrain morphology (HP:0002418)3.93774701
25Abnormality of methionine metabolism (HP:0010901)3.89142907
26Conjugated hyperbilirubinemia (HP:0002908)3.83906873
27Gout (HP:0001997)3.83525764
28Hypolipoproteinemia (HP:0010981)3.78300193
29Abnormality of pyrimidine metabolism (HP:0004353)3.77469937
30True hermaphroditism (HP:0010459)3.73054197
31Epidermoid cyst (HP:0200040)3.68011222
32Abnormality of nucleobase metabolism (HP:0010932)3.60522274
33Fat malabsorption (HP:0002630)3.55218604
34Hypoalphalipoproteinemia (HP:0003233)3.54711384
35Abnormality of fatty-acid metabolism (HP:0004359)3.54461493
36Ketoacidosis (HP:0001993)3.54350024
37Abnormality of purine metabolism (HP:0004352)3.52048443
38Hypoglycemic coma (HP:0001325)3.48691107
39Proximal tubulopathy (HP:0000114)3.47043286
40Delayed CNS myelination (HP:0002188)3.43850017
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.43683051
42Attenuation of retinal blood vessels (HP:0007843)3.43625383
43Abolished electroretinogram (ERG) (HP:0000550)3.35520226
44Abnormality of the common coagulation pathway (HP:0010990)3.35141087
45Vascular calcification (HP:0004934)3.31328170
46Abnormality of the renal cortex (HP:0011035)3.25827833
47Nephronophthisis (HP:0000090)3.23682805
48Generalized aminoaciduria (HP:0002909)3.19479035
49Abnormality of serum amino acid levels (HP:0003112)3.19387908
50Alkalosis (HP:0001948)3.17218731
51Decreased central vision (HP:0007663)3.06801931
52Enlarged kidneys (HP:0000105)3.02349419
53Hyperventilation (HP:0002883)3.00925125
54Metabolic acidosis (HP:0001942)3.00265321
55Abnormality of the renal medulla (HP:0100957)2.95498403
56Cardiovascular calcification (HP:0011915)2.90304133
57Gaze-evoked nystagmus (HP:0000640)2.89192584
58Hyperalaninemia (HP:0003348)2.87637334
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.87637334
60Abnormality of alanine metabolism (HP:0010916)2.87637334
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.87410256
62Hyperbilirubinemia (HP:0002904)2.86289152
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.85010888
64Dicarboxylic aciduria (HP:0003215)2.85010888
65Hypercholesterolemia (HP:0003124)2.83558783
66Increased purine levels (HP:0004368)2.83279361
67Hyperuricemia (HP:0002149)2.83279361
68Glycosuria (HP:0003076)2.82910330
69Abnormality of urine glucose concentration (HP:0011016)2.82910330
70Abnormality of the intrinsic pathway (HP:0010989)2.82671007
71Abnormality of complement system (HP:0005339)2.78105902
72Chronic hepatic failure (HP:0100626)2.77877798
73Type II lissencephaly (HP:0007260)2.77570007
74Lethargy (HP:0001254)2.77347973
75Hepatocellular carcinoma (HP:0001402)2.74287072
76Medial flaring of the eyebrow (HP:0010747)2.70408823
77Cystic liver disease (HP:0006706)2.69260896
78Chorioretinal atrophy (HP:0000533)2.68704575
79Keratoconus (HP:0000563)2.67715605
80Increased corneal curvature (HP:0100692)2.67715605
81Renal cortical cysts (HP:0000803)2.67478768
82Abnormal rod and cone electroretinograms (HP:0008323)2.67001735
83Rickets (HP:0002748)2.66117458
84Aplasia/Hypoplasia of the tibia (HP:0005772)2.65158573
85Steatorrhea (HP:0002570)2.64615267
86Genetic anticipation (HP:0003743)2.64520591
87Pendular nystagmus (HP:0012043)2.62702108
88Increased circulating renin level (HP:0000848)2.60175819
89Decreased electroretinogram (ERG) amplitude (HP:0000654)2.57532522
90Hypokalemic alkalosis (HP:0001949)2.56100484
91Hypophosphatemic rickets (HP:0004912)2.53741644
92Hyperactive renin-angiotensin system (HP:0000841)2.53616121
93Dynein arm defect of respiratory motile cilia (HP:0012255)2.50204628
94Absent/shortened dynein arms (HP:0200106)2.50204628
95Bony spicule pigmentary retinopathy (HP:0007737)2.49527413
96Hypoglycemic seizures (HP:0002173)2.49228805
97Decreased circulating renin level (HP:0003351)2.48797729
98Tubular atrophy (HP:0000092)2.45109159
99Inability to walk (HP:0002540)2.44138814
100Congenital sensorineural hearing impairment (HP:0008527)2.42458041
101Progressive cerebellar ataxia (HP:0002073)2.41425505
102Furrowed tongue (HP:0000221)2.39535598
103Abnormal drinking behavior (HP:0030082)2.39300078
104Polydipsia (HP:0001959)2.39300078
105Confusion (HP:0001289)2.38205003
106Hydroxyprolinuria (HP:0003080)2.36920682
107Abnormality of proline metabolism (HP:0010907)2.36920682
108Metabolic alkalosis (HP:0200114)2.36650222
109Progressive inability to walk (HP:0002505)2.36177827
110Vomiting (HP:0002013)2.33823213
111Myocardial infarction (HP:0001658)2.33763166
112Methylmalonic acidemia (HP:0002912)2.32510316
113Systemic lupus erythematosus (HP:0002725)2.31681586
114Aplasia/Hypoplasia of the tongue (HP:0010295)2.30888370
115Irritability (HP:0000737)2.30075044
116Renal tubular acidosis (HP:0001947)2.26795721
117Hypochromic microcytic anemia (HP:0004840)2.25929793
118Large for gestational age (HP:0001520)2.25862305
119Cerebral edema (HP:0002181)2.25747829
120Sclerocornea (HP:0000647)2.25647291
121Constricted visual fields (HP:0001133)2.23709631
122Hypomagnesemia (HP:0002917)2.21540124
123Abnormal urine output (HP:0012590)2.20998456
124Gait imbalance (HP:0002141)2.19760949
125Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19336603
126Malnutrition (HP:0004395)2.18006341
127Congenital primary aphakia (HP:0007707)2.16928734
128Abnormal enzyme/coenzyme activity (HP:0012379)2.16517017
129Abnormality of macular pigmentation (HP:0008002)2.15957712
130Stomach cancer (HP:0012126)2.14531158
131Pancreatitis (HP:0001733)2.13954839
132Methylmalonic aciduria (HP:0012120)2.13215969
133Abnormality of chloride homeostasis (HP:0011422)2.12667114
134Febrile seizures (HP:0002373)2.10290280
135Sensorimotor neuropathy (HP:0007141)2.10196801
136Spontaneous abortion (HP:0005268)2.09690158
137Opisthotonus (HP:0002179)2.09357584
138Fair hair (HP:0002286)2.08901125
139Hemiparesis (HP:0001269)2.08443451
140Increased CSF lactate (HP:0002490)2.08217021
141Abnormality of renal excretion (HP:0011036)2.07744077
142Hypothermia (HP:0002045)2.07020898
143Polyuria (HP:0000103)2.06853108
144Mitral stenosis (HP:0001718)2.05395555
145Broad-based gait (HP:0002136)2.04711028
146Neonatal onset (HP:0003623)2.04437794
147Genital tract atresia (HP:0001827)2.03145799
148Concave nail (HP:0001598)2.01783111
149Glomerulonephritis (HP:0000099)2.00414341
150Hyperphosphaturia (HP:0003109)2.00149360
151Symptomatic seizures (HP:0011145)1.99372799
152Clumsiness (HP:0002312)1.98397210
153Congenital hepatic fibrosis (HP:0002612)1.98198360
154Severe muscular hypotonia (HP:0006829)1.97743970
155Nephrolithiasis (HP:0000787)1.97338629
156Late onset (HP:0003584)1.97249727
157Nephrogenic diabetes insipidus (HP:0009806)1.96395400
158Abnormality of alkaline phosphatase activity (HP:0004379)1.95515556
159Hypophosphatemia (HP:0002148)1.91920710
160Elevated alkaline phosphatase (HP:0003155)1.90293953
161Cerebellar dysplasia (HP:0007033)1.89710592
162Short tibia (HP:0005736)1.88970523
163Nausea (HP:0002018)1.88193968
164Skin nodule (HP:0200036)1.87319870
165Abnormal urine phosphate concentration (HP:0012599)1.85767121
166Menorrhagia (HP:0000132)1.85112903
167Mitochondrial inheritance (HP:0001427)1.83880012
168Postaxial foot polydactyly (HP:0001830)1.82162293
169Male pseudohermaphroditism (HP:0000037)1.82110231
170Abnormality of the renal collecting system (HP:0004742)1.81188003
171Vaginal atresia (HP:0000148)1.80460340
172Abnormality of the pons (HP:0007361)1.80186112
173Abnormal biliary tract physiology (HP:0012439)1.80008131
174Bile duct proliferation (HP:0001408)1.80008131
175Progressive microcephaly (HP:0000253)1.79219963
176Anencephaly (HP:0002323)1.79127450
177Thyroiditis (HP:0100646)1.79081735
1783-Methylglutaconic aciduria (HP:0003535)1.78644208
179Hypoplasia of the pons (HP:0012110)1.78116879
180Protruding tongue (HP:0010808)1.76859809
181Lissencephaly (HP:0001339)1.75966895
182Retinitis pigmentosa (HP:0000510)1.69604510
183Abnormal respiratory motile cilium morphology (HP:0005938)1.69288132
184Abnormal respiratory epithelium morphology (HP:0012253)1.69288132
185Abnormality of vitamin B metabolism (HP:0004340)1.68833874
186Intestinal atresia (HP:0011100)1.68370033
187Absent speech (HP:0001344)1.68319127
188Small hand (HP:0200055)1.68064749
189Hepatic necrosis (HP:0002605)1.67380250
190Congenital, generalized hypertrichosis (HP:0004540)1.67292406
191Tachypnea (HP:0002789)1.66638940
192Acute encephalopathy (HP:0006846)1.66010162
193Increased serum lactate (HP:0002151)1.64647039
194Hypoplasia of the uterus (HP:0000013)1.64269501

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.14431622
2INSRR3.93607558
3WNK33.76946019
4WNK43.69342041
5OXSR13.09785117
6SIK13.04190883
7MAP4K23.02691799
8FGFR42.90776832
9STK38L2.81410154
10ACVR1B2.67897718
11IRAK32.65797678
12TAF12.22612602
13TLK12.16664042
14ERBB42.16525904
15TAOK32.08870837
16MAP3K141.86639578
17PINK11.84079915
18MST1R1.82625306
19PIK3CG1.67581058
20GRK11.64974239
21SGK21.62123817
22STK161.61544686
23LATS11.60353349
24CASK1.58593022
25FRK1.58346830
26SGK4941.57681376
27SGK2231.57681376
28MAPK131.52330543
29ERN11.48277018
30STK391.45945374
31ZAK1.40400343
32MKNK21.39660502
33IRAK21.36033764
34NEK61.27944256
35MAPK151.27723168
36MAPK111.23538892
37SGK31.20357829
38NTRK31.16528075
39MAPK71.13624423
40AKT31.11870625
41SIK31.11454768
42ADRBK11.11035821
43MAP2K41.10760010
44MAP3K41.10059741
45PRKAA21.08840935
46PAK31.05286254
47MAPK121.04425350
48ABL21.03765779
49TIE11.02940727
50MAPKAPK31.01353108
51IRAK10.96799240
52ADRBK20.96541687
53FGFR20.96334319
54MUSK0.95836018
55NEK90.91595705
56TGFBR10.90034112
57PHKG20.89508911
58PHKG10.89508911
59TRIM280.89175167
60NUAK10.89119613
61PTK2B0.86115736
62CAMKK20.84730858
63EIF2AK20.84059981
64IRAK40.83336594
65PKN10.82242030
66TYK20.82201478
67PBK0.81832958
68IKBKB0.80533280
69PLK20.80393743
70VRK10.78932634
71BRSK20.78024638
72CSNK1G30.77622365
73NTRK20.76926469
74CSNK1G20.74641164
75CSNK1A1L0.74628851
76MAPKAPK50.72859052
77FLT30.71134775
78MAPK40.70947298
79EPHA30.69959692
80GSK3A0.68764285
81JAK10.68233477
82MST40.67961153
83PRKCG0.66795992
84MAP3K70.66795721
85PRKCZ0.66784399
86PRKAA10.66414373
87BMPR20.66153726
88TEC0.65653463
89TRPM70.64275966
90OBSCN0.64243012
91PIK3CA0.61275999
92VRK20.60111435
93ERBB20.60016520
94EPHA40.59575677
95TXK0.58101384
96MAP2K70.56517993
97CAMK2G0.55843061
98CAMK2A0.55525797
99DAPK20.55234192
100JAK20.54577573
101MAP2K10.54088170
102RPS6KA50.53776849
103MKNK10.52611066
104STK110.52250057
105PRKACG0.50113696
106DYRK20.50024567
107YES10.49997943
108IGF1R0.49518236
109CDK60.49075891
110TGFBR20.48993318
111PRKCE0.48975630
112PLK30.48868718
113EIF2AK30.48738906
114IKBKE0.48524784
115PDK20.48068468
116CSNK1A10.47174760
117GRK50.45165420
118KIT0.45158620
119MET0.45091712
120CAMK10.44871371
121STK30.43563554
122NLK0.42713328
123PRKCI0.42506804
124KDR0.42435020
125PRKCQ0.41967433
126CHEK20.41810518
127STK380.40635483
128BMPR1B0.39754900
129GRK70.39302907
130CSK0.38991415
131DYRK1B0.38952956
132FER0.38761547
133ITK0.37920833
134PRKCA0.37853220
135SGK10.37761260
136CSNK1G10.37196973
137CSNK1D0.36325403
138TNIK0.36295869
139NME10.36049801
140ERBB30.35353608
141PRKACA0.32724250
142PLK10.31507202
143MAP2K20.31401478
144TNK20.30932923
145BLK0.30892517
146MAP3K30.30491902
147PRKG10.30483445
148PTK60.29811630
149PNCK0.28957748
150CAMK1D0.28863464
151PRKACB0.28551904
152WNK10.27896168
153CHUK0.27215219
154CAMK40.26236734
155PRKCD0.25738030
156MAP2K60.25644419
157GRK60.25031312

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.99339705
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.46294945
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.80009307
4Tryptophan metabolism_Homo sapiens_hsa003802.78076721
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.68991240
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67522842
7Nitrogen metabolism_Homo sapiens_hsa009102.65551591
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.62997381
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61606808
10Butanoate metabolism_Homo sapiens_hsa006502.59199767
11Phototransduction_Homo sapiens_hsa047442.57042699
12Arginine biosynthesis_Homo sapiens_hsa002202.56030489
13Fatty acid degradation_Homo sapiens_hsa000712.51710914
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50894438
15Peroxisome_Homo sapiens_hsa041462.42601002
16Complement and coagulation cascades_Homo sapiens_hsa046102.32087997
17Propanoate metabolism_Homo sapiens_hsa006402.24160749
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16119168
19Steroid hormone biosynthesis_Homo sapiens_hsa001402.06715569
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06257085
21Histidine metabolism_Homo sapiens_hsa003402.05266321
22beta-Alanine metabolism_Homo sapiens_hsa004102.03932536
23Homologous recombination_Homo sapiens_hsa034401.92979203
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88904947
25Chemical carcinogenesis_Homo sapiens_hsa052041.86326352
26Fatty acid metabolism_Homo sapiens_hsa012121.84815835
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.84594012
28PPAR signaling pathway_Homo sapiens_hsa033201.78104762
29Retinol metabolism_Homo sapiens_hsa008301.77966399
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73794622
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.63281529
32Phenylalanine metabolism_Homo sapiens_hsa003601.57649589
33Nicotine addiction_Homo sapiens_hsa050331.56382145
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56304825
35RNA polymerase_Homo sapiens_hsa030201.53887267
36Vitamin digestion and absorption_Homo sapiens_hsa049771.50690265
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49834629
38Bile secretion_Homo sapiens_hsa049761.49489672
39Sulfur metabolism_Homo sapiens_hsa009201.48646700
40Oxidative phosphorylation_Homo sapiens_hsa001901.48446477
41Pyruvate metabolism_Homo sapiens_hsa006201.47768713
42Fatty acid elongation_Homo sapiens_hsa000621.45360340
43Staphylococcus aureus infection_Homo sapiens_hsa051501.44611741
44Basal transcription factors_Homo sapiens_hsa030221.44483023
45Olfactory transduction_Homo sapiens_hsa047401.43738926
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.43184875
47Selenocompound metabolism_Homo sapiens_hsa004501.41073384
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40355150
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39692123
50Tyrosine metabolism_Homo sapiens_hsa003501.38911003
51Starch and sucrose metabolism_Homo sapiens_hsa005001.37257298
52Taste transduction_Homo sapiens_hsa047421.33624987
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33334471
54ABC transporters_Homo sapiens_hsa020101.24727621
55Caffeine metabolism_Homo sapiens_hsa002321.23905133
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23178814
57Arginine and proline metabolism_Homo sapiens_hsa003301.22869094
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22701907
59Folate biosynthesis_Homo sapiens_hsa007901.21320247
60Steroid biosynthesis_Homo sapiens_hsa001001.20417643
61Maturity onset diabetes of the young_Homo sapiens_hsa049501.18975649
62Protein export_Homo sapiens_hsa030601.18207988
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15340294
64Fanconi anemia pathway_Homo sapiens_hsa034601.14644624
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.09998051
66Morphine addiction_Homo sapiens_hsa050321.09291497
67Parkinsons disease_Homo sapiens_hsa050121.03105789
68Carbon metabolism_Homo sapiens_hsa012001.01746509
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01702827
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.95308797
71Non-homologous end-joining_Homo sapiens_hsa034500.92524781
72* Lysine degradation_Homo sapiens_hsa003100.92382730
73Biosynthesis of amino acids_Homo sapiens_hsa012300.90739221
74Insulin secretion_Homo sapiens_hsa049110.89924444
75Sulfur relay system_Homo sapiens_hsa041220.89272009
76RNA degradation_Homo sapiens_hsa030180.86751075
77Serotonergic synapse_Homo sapiens_hsa047260.86024435
78Circadian entrainment_Homo sapiens_hsa047130.85792938
79Glutathione metabolism_Homo sapiens_hsa004800.84968300
80Fat digestion and absorption_Homo sapiens_hsa049750.82246233
81Vitamin B6 metabolism_Homo sapiens_hsa007500.81809131
82One carbon pool by folate_Homo sapiens_hsa006700.76864335
83Purine metabolism_Homo sapiens_hsa002300.76608013
84Huntingtons disease_Homo sapiens_hsa050160.74114551
85Calcium signaling pathway_Homo sapiens_hsa040200.71937286
86Glycerolipid metabolism_Homo sapiens_hsa005610.69034402
87Alzheimers disease_Homo sapiens_hsa050100.67330084
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66892234
89Salivary secretion_Homo sapiens_hsa049700.66340477
90Glutamatergic synapse_Homo sapiens_hsa047240.66271635
91GABAergic synapse_Homo sapiens_hsa047270.66175578
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63965255
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61047319
94Cardiac muscle contraction_Homo sapiens_hsa042600.57827105
95* Metabolic pathways_Homo sapiens_hsa011000.57289344
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53424353
97Dorso-ventral axis formation_Homo sapiens_hsa043200.52206769
98Primary immunodeficiency_Homo sapiens_hsa053400.49882587
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.45477244
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43056975
101Asthma_Homo sapiens_hsa053100.42451690
102Pentose phosphate pathway_Homo sapiens_hsa000300.40763511
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39639026
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38126664
105Pyrimidine metabolism_Homo sapiens_hsa002400.37920368
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35458152
107Fatty acid biosynthesis_Homo sapiens_hsa000610.34057237
108Renin secretion_Homo sapiens_hsa049240.31894453
109Circadian rhythm_Homo sapiens_hsa047100.31169153
110Linoleic acid metabolism_Homo sapiens_hsa005910.30752961
111Long-term depression_Homo sapiens_hsa047300.29910780
112Type I diabetes mellitus_Homo sapiens_hsa049400.29669660
113Fructose and mannose metabolism_Homo sapiens_hsa000510.28113687
114Arachidonic acid metabolism_Homo sapiens_hsa005900.22241127
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18645125
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17575871
117Galactose metabolism_Homo sapiens_hsa000520.17313352
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.10713331
119Mineral absorption_Homo sapiens_hsa049780.10406175
120Other glycan degradation_Homo sapiens_hsa005110.09929601
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.09806762
122Prion diseases_Homo sapiens_hsa050200.06957692
123Insulin resistance_Homo sapiens_hsa049310.06323504
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.01956107
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.1646242
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.1606250
127Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1591789
128Lysosome_Homo sapiens_hsa04142-0.1457763
129Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1433257
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1253983
131AMPK signaling pathway_Homo sapiens_hsa04152-0.1019927
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0914774
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0883133
134Collecting duct acid secretion_Homo sapiens_hsa04966-0.0799085
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0698698
136Ether lipid metabolism_Homo sapiens_hsa00565-0.0664599
137Sphingolipid metabolism_Homo sapiens_hsa00600-0.0404659
138Renin-angiotensin system_Homo sapiens_hsa04614-0.0286389
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0268059
140Glucagon signaling pathway_Homo sapiens_hsa04922-0.0186837
141Regulation of autophagy_Homo sapiens_hsa04140-0.0113340
142Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0061289
143Protein digestion and absorption_Homo sapiens_hsa04974-0.0029029

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