HYLS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein localized to the cytoplasm. Mutations in this gene are associated with hydrolethalus syndrome. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.18427275
2regulation of meiosis I (GO:0060631)5.03147059
3synapsis (GO:0007129)4.51471113
4ribosomal small subunit assembly (GO:0000028)4.42342436
5cilium or flagellum-dependent cell motility (GO:0001539)4.26942051
6piRNA metabolic process (GO:0034587)4.26596180
7microtubule depolymerization (GO:0007019)4.07085546
8meiotic chromosome segregation (GO:0045132)4.01243430
9anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.99082299
10cullin deneddylation (GO:0010388)3.98449541
11fusion of sperm to egg plasma membrane (GO:0007342)3.98292229
12viral transcription (GO:0019083)3.89885234
13rRNA modification (GO:0000154)3.77531416
14regulation of spindle organization (GO:0090224)3.77256217
15male meiosis (GO:0007140)3.76417186
16translational termination (GO:0006415)3.76028099
17spindle checkpoint (GO:0031577)3.73812068
18sperm-egg recognition (GO:0035036)3.73172380
19nuclear pore complex assembly (GO:0051292)3.71489778
20kinetochore organization (GO:0051383)3.71125189
21regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66703066
22protein deneddylation (GO:0000338)3.62812783
23rRNA methylation (GO:0031167)3.62392371
24binding of sperm to zona pellucida (GO:0007339)3.61951214
25motile cilium assembly (GO:0044458)3.61352654
26axonemal dynein complex assembly (GO:0070286)3.60982676
27regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.60329207
28protein localization to chromosome, centromeric region (GO:0071459)3.59838951
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.58061328
30chromatin remodeling at centromere (GO:0031055)3.57063136
31acrosome assembly (GO:0001675)3.52942081
32regulation of mitotic spindle checkpoint (GO:1903504)3.52432244
33regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.52432244
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51263995
35regulation of DNA methylation (GO:0044030)3.50799454
36DNA replication checkpoint (GO:0000076)3.50109545
37microtubule polymerization or depolymerization (GO:0031109)3.49397582
38multicellular organism reproduction (GO:0032504)3.46624713
39CENP-A containing nucleosome assembly (GO:0034080)3.46045556
40DNA deamination (GO:0045006)3.45784475
41resolution of meiotic recombination intermediates (GO:0000712)3.45656937
42nuclear pore organization (GO:0006999)3.44863490
43positive regulation of chromosome segregation (GO:0051984)3.44772148
44negative regulation of DNA-dependent DNA replication (GO:2000104)3.44577735
45mitotic sister chromatid cohesion (GO:0007064)3.44404475
46histone exchange (GO:0043486)3.43860686
47mitotic spindle checkpoint (GO:0071174)3.42772526
48DNA methylation involved in gamete generation (GO:0043046)3.41048701
49positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.40876619
50positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.40876619
51positive regulation of mitotic sister chromatid separation (GO:1901970)3.40876619
52centriole assembly (GO:0098534)3.40263439
53sperm motility (GO:0030317)3.35760374
54cell-cell recognition (GO:0009988)3.35680999
55mitotic sister chromatid segregation (GO:0000070)3.34159353
56ribosomal small subunit biogenesis (GO:0042274)3.31343949
57negative regulation of chromosome segregation (GO:0051985)3.30677005
58negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.28924241
59negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.28924241
60negative regulation of mitotic sister chromatid segregation (GO:0033048)3.28924241
61negative regulation of mitotic sister chromatid separation (GO:2000816)3.28924241
62negative regulation of sister chromatid segregation (GO:0033046)3.28924241
63mitotic metaphase plate congression (GO:0007080)3.28351185
64pteridine-containing compound biosynthetic process (GO:0042559)3.27128677
65epithelial cilium movement (GO:0003351)3.26566418
66translational elongation (GO:0006414)3.24622594
67protein localization to kinetochore (GO:0034501)3.24332443
68DNA replication-dependent nucleosome assembly (GO:0006335)3.23201584
69DNA replication-dependent nucleosome organization (GO:0034723)3.23201584
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.23007446
71negative regulation of ligase activity (GO:0051352)3.23007446
72male meiosis I (GO:0007141)3.22425698
73regulation of mitotic metaphase/anaphase transition (GO:0030071)3.21276960
74regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.21276960
75chromosome segregation (GO:0007059)3.21224438
76nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.20767684
77establishment of integrated proviral latency (GO:0075713)3.19188313
78RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18850462
79tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18850462
80kinetochore assembly (GO:0051382)3.18669222
81mitotic spindle assembly checkpoint (GO:0007094)3.18658176
82ribosomal large subunit biogenesis (GO:0042273)3.18601662
83metaphase plate congression (GO:0051310)3.18579186
84regulation of DNA endoreduplication (GO:0032875)3.18326643
85protein K6-linked ubiquitination (GO:0085020)3.18202465
86establishment of protein localization to mitochondrial membrane (GO:0090151)3.18181750
87spermatid development (GO:0007286)3.18117046
88maturation of SSU-rRNA (GO:0030490)3.17938905
89DNA replication-independent nucleosome organization (GO:0034724)3.17610500
90DNA replication-independent nucleosome assembly (GO:0006336)3.17610500
91spindle assembly checkpoint (GO:0071173)3.17132156
92exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16968910
93epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.16827271
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16187959
95regulation of sister chromatid segregation (GO:0033045)3.16043228
96regulation of mitotic sister chromatid separation (GO:0010965)3.16043228
97regulation of mitotic sister chromatid segregation (GO:0033047)3.16043228
98centriole replication (GO:0007099)3.15588790
99sister chromatid segregation (GO:0000819)3.14583749
100meiotic cell cycle (GO:0051321)3.14231200
101DNA replication initiation (GO:0006270)3.12383246
102meiotic cell cycle process (GO:1903046)3.11702187
103regulation of histone H3-K9 methylation (GO:0051570)3.11400472
104histone mRNA metabolic process (GO:0008334)3.06567040
105SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04007143
106cell wall macromolecule catabolic process (GO:0016998)3.03544958
107cell wall macromolecule metabolic process (GO:0044036)3.03544958
108meiotic nuclear division (GO:0007126)3.02609407
109positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.02486967
110synaptonemal complex organization (GO:0070193)3.02377639
111regulation of spindle checkpoint (GO:0090231)3.01827561
112synaptonemal complex assembly (GO:0007130)3.01621344
113chromosome organization involved in meiosis (GO:0070192)3.00833009
114telomere maintenance via semi-conservative replication (GO:0032201)2.98177878
115telomere maintenance via recombination (GO:0000722)2.97298361
116translational initiation (GO:0006413)2.96230555
117cellular protein complex disassembly (GO:0043624)2.96086134
118attachment of spindle microtubules to kinetochore (GO:0008608)2.95961986
119histone H2A acetylation (GO:0043968)2.95846679
120regulation of centriole replication (GO:0046599)2.95148431
121mitochondrial RNA metabolic process (GO:0000959)2.95117938
122cotranslational protein targeting to membrane (GO:0006613)2.94503227
123histone-serine phosphorylation (GO:0035404)2.93471828
124mitotic nuclear envelope disassembly (GO:0007077)2.93016249
125protein targeting to ER (GO:0045047)2.92826251
126negative regulation of mitosis (GO:0045839)2.92424685
127translesion synthesis (GO:0019985)2.92239740
128regulation of histone H3-K27 methylation (GO:0061085)2.91883425
129chaperone-mediated protein transport (GO:0072321)2.91518351
130protein localization to chromosome (GO:0034502)2.89261403
131pseudouridine synthesis (GO:0001522)2.89242769
132mitotic recombination (GO:0006312)2.89169349
133DNA damage response, detection of DNA damage (GO:0042769)2.89017925
134DNA ligation (GO:0006266)2.88837332
135mitotic chromosome condensation (GO:0007076)2.88462797
136meiosis I (GO:0007127)2.88429829
137sister chromatid cohesion (GO:0007062)2.88003024
138positive regulation of ligase activity (GO:0051351)2.87350009
139regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.87166601
140viral life cycle (GO:0019058)2.84451828
141chromatin assembly or disassembly (GO:0006333)2.84115688
142cilium movement (GO:0003341)2.82365176
143maturation of 5.8S rRNA (GO:0000460)2.81367263
144DNA strand elongation involved in DNA replication (GO:0006271)2.81137739
145pore complex assembly (GO:0046931)2.80759176
146protein complex disassembly (GO:0043241)2.80225413
147DNA packaging (GO:0006323)2.80158444
148plasma membrane fusion (GO:0045026)2.79728898
149gene silencing by RNA (GO:0031047)2.79626015
150chromosome condensation (GO:0030261)2.79086977
151ATP-dependent chromatin remodeling (GO:0043044)2.77485598
152establishment of protein localization to endoplasmic reticulum (GO:0072599)2.77311138
153establishment of chromosome localization (GO:0051303)2.75421890
154regulation of chromosome segregation (GO:0051983)2.75374822
155DNA strand elongation (GO:0022616)2.74302897
156regulation of centrosome cycle (GO:0046605)2.73528792
157nuclear-transcribed mRNA catabolic process (GO:0000956)2.71946753
158DNA unwinding involved in DNA replication (GO:0006268)2.71852780
159DNA double-strand break processing (GO:0000729)2.70237777
160protein localization to endoplasmic reticulum (GO:0070972)2.69094822
161DNA alkylation (GO:0006305)2.68435371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.94803367
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.47181651
3* FOXM1_23109430_ChIP-Seq_U2OS_Human5.42101484
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.81065071
5E2F4_17652178_ChIP-ChIP_JURKAT_Human4.37335319
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.90569675
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.32296728
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.52293991
9ZNF274_21170338_ChIP-Seq_K562_Hela2.44801419
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42398889
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.38891184
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26012484
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22623538
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.20065382
15MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.15481594
16EZH2_22144423_ChIP-Seq_EOC_Human2.02921766
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02217421
18E2F1_21310950_ChIP-Seq_MCF-7_Human1.97452693
19NOTCH1_21737748_ChIP-Seq_TLL_Human1.94689388
20VDR_23849224_ChIP-Seq_CD4+_Human1.94311281
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89959513
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87422397
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.87315637
24VDR_22108803_ChIP-Seq_LS180_Human1.81984585
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80673625
26FOXP3_21729870_ChIP-Seq_TREG_Human1.78660967
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78312959
28XRN2_22483619_ChIP-Seq_HELA_Human1.74910072
29EWS_26573619_Chip-Seq_HEK293_Human1.74469213
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73758172
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.72469205
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71011799
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69402367
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69400448
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68476088
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.67676714
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.63576165
38TTF2_22483619_ChIP-Seq_HELA_Human1.62409336
39ELK1_19687146_ChIP-ChIP_HELA_Human1.60955273
40MYC_22102868_ChIP-Seq_BL_Human1.59998308
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.59454976
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.56925589
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55047824
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53717795
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50492563
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49802778
47AR_21909140_ChIP-Seq_LNCAP_Human1.49669472
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49215575
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48542329
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46176336
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45978962
52FUS_26573619_Chip-Seq_HEK293_Human1.39451167
53* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38768804
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37560367
55SCL_19346495_ChIP-Seq_HPC-7_Human1.37347437
56* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36873958
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36440771
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35963963
59DCP1A_22483619_ChIP-Seq_HELA_Human1.35708079
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35460864
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35002243
62CIITA_25753668_ChIP-Seq_RAJI_Human1.34785286
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34597737
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34189897
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.31757340
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.31510760
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30395633
68* GABP_19822575_ChIP-Seq_HepG2_Human1.29421579
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29003042
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28783759
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28718498
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26339709
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25783210
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23967949
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23885644
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21184320
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21184320
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21184320
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20564451
80IRF1_19129219_ChIP-ChIP_H3396_Human1.19988280
81MYC_18940864_ChIP-ChIP_HL60_Human1.17938010
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.17602030
83TP53_22573176_ChIP-Seq_HFKS_Human1.14747340
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13076600
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12855552
86TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12683720
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11417129
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10507710
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09937231
90MYB_26560356_Chip-Seq_TH1_Human1.09516286
91MYB_26560356_Chip-Seq_TH2_Human1.08823674
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07678476
93SPI1_23547873_ChIP-Seq_NB4_Human1.07387429
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04876078
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03767406
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03613074
97* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03519375
98P300_19829295_ChIP-Seq_ESCs_Human1.03291803
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00946492
100STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99595928
101KDM5A_27292631_Chip-Seq_BREAST_Human0.98172866
102HTT_18923047_ChIP-ChIP_STHdh_Human0.96024220
103MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95669966
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95342050
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94901177
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92114334
107CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91797025
108FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91447519
109ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91184982
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90333947
111CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89136094
112IGF1R_20145208_ChIP-Seq_DFB_Human0.89113006
113GBX2_23144817_ChIP-Seq_PC3_Human0.88709790
114ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88323720
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88103107
116ELK1_22589737_ChIP-Seq_MCF10A_Human0.88050193
117GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86565171
118HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86241764
119IRF8_22096565_ChIP-ChIP_GC-B_Human0.85931153
120KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85255032
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85207813
122KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85003974
123* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83516873
124* FOXA1_25329375_ChIP-Seq_VCAP_Human0.83516873
125THAP11_20581084_ChIP-Seq_MESCs_Mouse0.83122262
126MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82863924
127YY1_21170310_ChIP-Seq_MESCs_Mouse0.82763774
128PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81875672
129SOX2_16153702_ChIP-ChIP_HESCs_Human0.81642408
130SRF_21415370_ChIP-Seq_HL-1_Mouse0.81372565
131VDR_21846776_ChIP-Seq_THP-1_Human0.80451996
132* MAF_26560356_Chip-Seq_TH1_Human0.80370520
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.79593443
134UTX_26944678_Chip-Seq_JUKART_Human0.79110348
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79000508
136CBP_20019798_ChIP-Seq_JUKART_Human0.79000508
137STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.78870568
138PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.76631074
139TAF15_26573619_Chip-Seq_HEK293_Human0.75555851

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.10222924
2MP0005410_abnormal_fertilization3.55834235
3MP0003693_abnormal_embryo_hatching3.45254068
4MP0003111_abnormal_nucleus_morphology3.17862656
5MP0008058_abnormal_DNA_repair2.97192010
6MP0003077_abnormal_cell_cycle2.96183539
7MP0003136_yellow_coat_color2.95788383
8MP0008057_abnormal_DNA_replication2.84108294
9MP0008877_abnormal_DNA_methylation2.81060079
10MP0003890_abnormal_embryonic-extraembry2.66038292
11MP0006292_abnormal_olfactory_placode2.64688979
12MP0008789_abnormal_olfactory_epithelium2.64573479
13MP0008007_abnormal_cellular_replicative2.55470202
14MP0004957_abnormal_blastocyst_morpholog2.55054012
15MP0001929_abnormal_gametogenesis2.42981593
16MP0002210_abnormal_sex_determination2.31184098
17MP0005174_abnormal_tail_pigmentation2.15894899
18MP0003763_abnormal_thymus_physiology2.15799350
19MP0003880_abnormal_central_pattern2.12561371
20MP0003698_abnormal_male_reproductive2.08495871
21MP0003950_abnormal_plasma_membrane2.04479472
22MP0004808_abnormal_hematopoietic_stem2.03892582
23MP0002234_abnormal_pharynx_morphology1.99897414
24MP0010030_abnormal_orbit_morphology1.99600801
25MP0002396_abnormal_hematopoietic_system1.93127441
26MP0000490_abnormal_crypts_of1.90041899
27MP0001145_abnormal_male_reproductive1.83995422
28MP0003786_premature_aging1.81258369
29MP0005395_other_phenotype1.79783542
30MP0005394_taste/olfaction_phenotype1.79684673
31MP0005499_abnormal_olfactory_system1.79684673
32MP0008932_abnormal_embryonic_tissue1.78814869
33MP0009379_abnormal_foot_pigmentation1.72879250
34MP0001188_hyperpigmentation1.71072479
35MP0004381_abnormal_hair_follicle1.69683365
36MP0002736_abnormal_nociception_after1.66872714
37MP0000653_abnormal_sex_gland1.66566694
38MP0003941_abnormal_skin_development1.64646883
39MP0005360_urolithiasis1.60497008
40MP0003806_abnormal_nucleotide_metabolis1.60406068
41MP0002095_abnormal_skin_pigmentation1.51660804
42MP0000015_abnormal_ear_pigmentation1.50801545
43MP0005409_darkened_coat_color1.50046873
44MP0005423_abnormal_somatic_nervous1.49407886
45MP0005671_abnormal_response_to1.48413096
46MP0006035_abnormal_mitochondrial_morpho1.44324416
47MP0002398_abnormal_bone_marrow1.43617284
48MP0009697_abnormal_copulation1.42044067
49MP0005075_abnormal_melanosome_morpholog1.41392052
50MP0003315_abnormal_perineum_morphology1.41021592
51MP0000350_abnormal_cell_proliferation1.40975293
52MP0003123_paternal_imprinting1.40883897
53MP0002102_abnormal_ear_morphology1.40487802
54MP0000703_abnormal_thymus_morphology1.39443336
55MP0006072_abnormal_retinal_apoptosis1.37446026
56MP0005397_hematopoietic_system_phenotyp1.35925654
57MP0001545_abnormal_hematopoietic_system1.35925654
58MP0001835_abnormal_antigen_presentation1.34066096
59MP0002160_abnormal_reproductive_system1.32091871
60MP0002019_abnormal_tumor_incidence1.32048142
61MP0002163_abnormal_gland_morphology1.30690540
62MP0005551_abnormal_eye_electrophysiolog1.30297125
63MP0006036_abnormal_mitochondrial_physio1.26612397
64MP0002161_abnormal_fertility/fecundity1.23720926
65MP0000689_abnormal_spleen_morphology1.21851296
66MP0001119_abnormal_female_reproductive1.20877191
67MP0001800_abnormal_humoral_immune1.18729544
68MP0002722_abnormal_immune_system1.18568228
69MP0003718_maternal_effect1.15934349
70MP0000313_abnormal_cell_death1.15720779
71MP0002138_abnormal_hepatobiliary_system1.15659479
72MP0010307_abnormal_tumor_latency1.15514700
73MP0003186_abnormal_redox_activity1.15413924
74MP0009333_abnormal_splenocyte_physiolog1.12374688
75MP0002735_abnormal_chemical_nociception1.08812525
76MP0001968_abnormal_touch/_nociception1.08316902
77MP0001529_abnormal_vocalization1.08282744
78MP0003119_abnormal_digestive_system1.07337152
79MP0000685_abnormal_immune_system1.06824247
80MP0005389_reproductive_system_phenotype1.06541887
81MP0000716_abnormal_immune_system1.05463417
82MP0002233_abnormal_nose_morphology1.04731194
83MP0009278_abnormal_bone_marrow1.03417415
84MP0001346_abnormal_lacrimal_gland1.02297103
85MP0004142_abnormal_muscle_tone1.02282917
86MP0002452_abnormal_antigen_presenting1.02200456
87MP0004133_heterotaxia1.01900482
88MP0002177_abnormal_outer_ear1.01814024
89MP0002420_abnormal_adaptive_immunity1.01472972
90MP0001293_anophthalmia1.01172322
91MP0001819_abnormal_immune_cell1.00049295
92MP0002429_abnormal_blood_cell0.98471608
93MP0002653_abnormal_ependyma_morphology0.97661772
94MP0005253_abnormal_eye_physiology0.97135370
95MP0004147_increased_porphyrin_level0.95857785
96MP0002009_preneoplasia0.95476101
97MP0001730_embryonic_growth_arrest0.95289449
98MP0001919_abnormal_reproductive_system0.94510131
99MP0000569_abnormal_digit_pigmentation0.93390918
100MP0001672_abnormal_embryogenesis/_devel0.93158958
101MP0005380_embryogenesis_phenotype0.93158958
102MP0002282_abnormal_trachea_morphology0.92665790
103MP0005379_endocrine/exocrine_gland_phen0.92538972
104MP0008995_early_reproductive_senescence0.92405995
105MP0002085_abnormal_embryonic_tissue0.92299888
106MP0000631_abnormal_neuroendocrine_gland0.92197661
107MP0001697_abnormal_embryo_size0.92040263
108MP0002132_abnormal_respiratory_system0.91176018
109MP0002938_white_spotting0.90623429
110MP0000566_synostosis0.90437659
111MP0002084_abnormal_developmental_patter0.89801559
112MP0000647_abnormal_sebaceous_gland0.89618345
113MP0002723_abnormal_immune_serum0.89002879
114MP0003121_genomic_imprinting0.88662335
115MP0000372_irregular_coat_pigmentation0.88495440
116MP0002080_prenatal_lethality0.87847685
117MP0002751_abnormal_autonomic_nervous0.86989152
118MP0002249_abnormal_larynx_morphology0.85997849
119MP0009785_altered_susceptibility_to0.84671744
120MP0001986_abnormal_taste_sensitivity0.82469491
121MP0000358_abnormal_cell_content/0.80959109
122MP0000049_abnormal_middle_ear0.80548522
123MP0001324_abnormal_eye_pigmentation0.79791547
124MP0002006_tumorigenesis0.79143964
125MP0002405_respiratory_system_inflammati0.79142332
126MP0003943_abnormal_hepatobiliary_system0.78510209
127MP0004197_abnormal_fetal_growth/weight/0.74208477
128MP0003787_abnormal_imprinting0.73988805
129MP0003937_abnormal_limbs/digits/tail_de0.73805443
130MP0003699_abnormal_female_reproductive0.73590182
131MP0002277_abnormal_respiratory_mucosa0.73369288
132MP0002086_abnormal_extraembryonic_tissu0.72638940
133MP0003195_calcinosis0.72221979
134MP0005670_abnormal_white_adipose0.71375222
135MP0002075_abnormal_coat/hair_pigmentati0.71302738
136MP0005076_abnormal_cell_differentiation0.71049419
137MP0002166_altered_tumor_susceptibility0.70161771
138MP0005000_abnormal_immune_tolerance0.70017312
139MP0008875_abnormal_xenobiotic_pharmacok0.69985913
140MP0003984_embryonic_growth_retardation0.69865630
141MP0000427_abnormal_hair_cycle0.69304105
142MP0003252_abnormal_bile_duct0.69022678
143MP0003183_abnormal_peptide_metabolism0.68833739
144MP0010155_abnormal_intestine_physiology0.68758008
145MP0005646_abnormal_pituitary_gland0.67624269
146MP0001286_abnormal_eye_development0.66789428
147MP0008872_abnormal_physiological_respon0.66070959
148MP0001486_abnormal_startle_reflex0.65341608
149MP0002272_abnormal_nervous_system0.64694380
150MP0006276_abnormal_autonomic_nervous0.63403155

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.56689397
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.99456267
3Absent/shortened dynein arms (HP:0200106)4.99456267
4Abnormal respiratory motile cilium physiology (HP:0012261)3.84590563
5Abnormality of the labia minora (HP:0012880)3.79210808
6Abnormality of cells of the erythroid lineage (HP:0012130)3.71580594
7Abnormal respiratory motile cilium morphology (HP:0005938)3.69292355
8Abnormal respiratory epithelium morphology (HP:0012253)3.69292355
9Abnormal number of erythroid precursors (HP:0012131)3.55339833
10Selective tooth agenesis (HP:0001592)3.51609429
11Rhinitis (HP:0012384)3.38079039
12Reticulocytopenia (HP:0001896)3.37562295
13Chromsome breakage (HP:0040012)3.37229271
14Abnormality of chromosome stability (HP:0003220)3.24568163
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.24062754
16Acute necrotizing encephalopathy (HP:0006965)3.13393329
17Abnormal ciliary motility (HP:0012262)3.03017815
18Abnormality of alanine metabolism (HP:0010916)2.98170273
19Hyperalaninemia (HP:0003348)2.98170273
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.98170273
21Abnormality of the preputium (HP:0100587)2.95249905
22Nasal polyposis (HP:0100582)2.93787218
23Meckel diverticulum (HP:0002245)2.91963884
24Bronchiectasis (HP:0002110)2.91297465
25Acute encephalopathy (HP:0006846)2.90560440
26Impulsivity (HP:0100710)2.86506326
2711 pairs of ribs (HP:0000878)2.82272299
28Increased CSF lactate (HP:0002490)2.81361705
29Mitochondrial inheritance (HP:0001427)2.80352994
30* Supernumerary spleens (HP:0009799)2.79558907
31Abnormality of the ileum (HP:0001549)2.78247992
32Chronic bronchitis (HP:0004469)2.74614742
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.74357383
34Abnormal mitochondria in muscle tissue (HP:0008316)2.73543705
35Carpal bone hypoplasia (HP:0001498)2.73459476
36Progressive macrocephaly (HP:0004481)2.72705441
37Abnormal spermatogenesis (HP:0008669)2.71398877
38Bronchitis (HP:0012387)2.71262972
39Recurrent bronchitis (HP:0002837)2.69028458
40Aplastic anemia (HP:0001915)2.61895275
41Absent thumb (HP:0009777)2.57228678
42Myelodysplasia (HP:0002863)2.55131711
43Pancreatic cysts (HP:0001737)2.54603739
44Oligodactyly (hands) (HP:0001180)2.52884371
45Increased hepatocellular lipid droplets (HP:0006565)2.49400331
46Volvulus (HP:0002580)2.49352056
47Hepatocellular necrosis (HP:0001404)2.45329332
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.45063771
49Nephronophthisis (HP:0000090)2.44112777
50Hepatic necrosis (HP:0002605)2.42044404
51Ectopic kidney (HP:0000086)2.41546643
52Pancreatic fibrosis (HP:0100732)2.41523432
53Clubbing of toes (HP:0100760)2.40790435
54Pallor (HP:0000980)2.39300753
55Aplasia/Hypoplasia involving the musculature (HP:0001460)2.38361665
56Increased serum lactate (HP:0002151)2.35322634
57Sloping forehead (HP:0000340)2.35223568
58Duodenal stenosis (HP:0100867)2.34059135
59Small intestinal stenosis (HP:0012848)2.34059135
60Infertility (HP:0000789)2.33294958
61Nephroblastoma (Wilms tumor) (HP:0002667)2.32707000
62Abnormality of the nasal mucosa (HP:0000433)2.29637832
63Medulloblastoma (HP:0002885)2.27410861
643-Methylglutaconic aciduria (HP:0003535)2.25825187
65Bile duct proliferation (HP:0001408)2.25602317
66Abnormal biliary tract physiology (HP:0012439)2.25602317
67Methylmalonic acidemia (HP:0002912)2.24798967
68Constricted visual fields (HP:0001133)2.19433276
69Hypoplasia of the radius (HP:0002984)2.18772133
70Azoospermia (HP:0000027)2.17258517
71Facial hemangioma (HP:0000329)2.16125269
72Lipid accumulation in hepatocytes (HP:0006561)2.14806458
73IgM deficiency (HP:0002850)2.14624208
74Agammaglobulinemia (HP:0004432)2.12581450
75Embryonal renal neoplasm (HP:0011794)2.11653771
76Recurrent sinusitis (HP:0011108)2.10962908
77Septo-optic dysplasia (HP:0100842)2.08116797
78Abnormal sex determination (HP:0012244)2.08036976
79Sex reversal (HP:0012245)2.08036976
80Tubulointerstitial nephritis (HP:0001970)2.07311636
81Type I transferrin isoform profile (HP:0003642)2.06703341
82Generalized aminoaciduria (HP:0002909)2.06550491
83Cerebral edema (HP:0002181)2.05372510
84Hypoplasia of the fovea (HP:0007750)2.03576887
85Aplasia/Hypoplasia of the fovea (HP:0008060)2.03576887
86Birth length less than 3rd percentile (HP:0003561)2.03015973
87Hypoplasia of the pons (HP:0012110)2.02577070
88Abnormality of the renal medulla (HP:0100957)2.02418194
89Acute myeloid leukemia (HP:0004808)2.02338776
90Type 2 muscle fiber atrophy (HP:0003554)2.02238755
91Muscle fiber atrophy (HP:0100295)2.02233931
92Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.01823510
93Horseshoe kidney (HP:0000085)2.00376346
94Abnormality of the pons (HP:0007361)2.00337261
95Macrocytic anemia (HP:0001972)1.99909021
96Renal Fanconi syndrome (HP:0001994)1.99575281
97Triphalangeal thumb (HP:0001199)1.98954081
98Abdominal situs inversus (HP:0003363)1.98906117
99Abnormality of abdominal situs (HP:0011620)1.98906117
100Rhabdomyosarcoma (HP:0002859)1.98847270
101Prominent nose (HP:0000448)1.98663474
102Lactic acidosis (HP:0003128)1.98597013
103Oligodactyly (HP:0012165)1.98539159
104Pendular nystagmus (HP:0012043)1.97534386
105Cleft eyelid (HP:0000625)1.95961759
106Absent radius (HP:0003974)1.95587796
107Small hand (HP:0200055)1.94533846
108Abnormality of DNA repair (HP:0003254)1.94103182
109Abnormality of the carotid arteries (HP:0005344)1.94049241
110Abnormality of the fovea (HP:0000493)1.93841466
111Aplasia of the musculature (HP:0100854)1.92926123
112Spinal muscular atrophy (HP:0007269)1.92519408
113Abnormality of the duodenum (HP:0002246)1.91656650
114Congenital sensorineural hearing impairment (HP:0008527)1.90457756
115Hypoplastic pelvis (HP:0008839)1.89370421
116Aplasia involving forearm bones (HP:0009822)1.88027481
117Absent forearm bone (HP:0003953)1.88027481
118Congenital, generalized hypertrichosis (HP:0004540)1.87390267
119Bone marrow hypocellularity (HP:0005528)1.86467926
120True hermaphroditism (HP:0010459)1.84728083
121Sclerocornea (HP:0000647)1.83623206
122Increased nuchal translucency (HP:0010880)1.83439057
123Methylmalonic aciduria (HP:0012120)1.82953716
124Recurrent otitis media (HP:0000403)1.82455049
125Ependymoma (HP:0002888)1.82305728
126Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82202681
127Colon cancer (HP:0003003)1.82120244
128Patellar aplasia (HP:0006443)1.81800201
129Medial flaring of the eyebrow (HP:0010747)1.80257304
130Thyroiditis (HP:0100646)1.80206648
131Reduced antithrombin III activity (HP:0001976)1.79585348
132Progressive inability to walk (HP:0002505)1.79339224
133Increased serum pyruvate (HP:0003542)1.79266532
134Poor speech (HP:0002465)1.78019803
135Abnormality of midbrain morphology (HP:0002418)1.77581227
136Molar tooth sign on MRI (HP:0002419)1.77581227
137Lymphoma (HP:0002665)1.77195567
138Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77152776
139Abnormality of serum amino acid levels (HP:0003112)1.77078744
140Amaurosis fugax (HP:0100576)1.75754856
141* Abnormal lung lobation (HP:0002101)1.75652917
142* Median cleft lip (HP:0000161)1.75263545
143Severe combined immunodeficiency (HP:0004430)1.75237878
144Abnormality of the fingertips (HP:0001211)1.75210545
145Thrombocytosis (HP:0001894)1.74816604
146Gonadotropin excess (HP:0000837)1.71731449
147Aplasia/Hypoplasia of the patella (HP:0006498)1.71472925
148Nonprogressive disorder (HP:0003680)1.71292599
149IgG deficiency (HP:0004315)1.70593668
150Pulmonary fibrosis (HP:0002206)1.70242337
151Squamous cell carcinoma (HP:0002860)1.67283201
152Asplenia (HP:0001746)1.65980219
153Tracheoesophageal fistula (HP:0002575)1.65758459
154Short thumb (HP:0009778)1.65456232
155Abnormal number of incisors (HP:0011064)1.64682453
156Forearm undergrowth (HP:0009821)1.64362484
157Truncal obesity (HP:0001956)1.64261392
158Meningitis (HP:0001287)1.61128604
159Mediastinal lymphadenopathy (HP:0100721)1.59977830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK13.56707915
2CDC73.50385722
3NEK23.37475045
4MKNK23.25131201
5TRIM282.89252555
6WEE12.88012497
7NME22.80455154
8TLK12.78110398
9BUB12.68090254
10MKNK12.64377343
11MUSK2.51766430
12NEK12.43137840
13VRK22.40831760
14MST42.37243635
15NUAK12.33714344
16TTK2.22699438
17DYRK32.18609589
18PDK42.15054075
19PDK32.15054075
20STK31.93717986
21PLK41.91133157
22CDK121.89694639
23PLK11.78895520
24EIF2AK11.75410932
25VRK11.73219873
26PBK1.72892354
27ATR1.66799579
28BRSK21.62735418
29BMPR1B1.62665635
30STK101.61017551
31TSSK61.53503061
32ACVR1B1.53038395
33AURKB1.52184428
34STK391.48335126
35MAP4K11.42200078
36CHEK21.41038985
37ARAF1.39055283
38CDK41.35597890
39TESK11.35425790
40PASK1.34871552
41PIM11.31933330
42RPS6KB21.31234769
43CDK71.30633722
44YES11.27216455
45PRKCI1.25427738
46EEF2K1.24517943
47BRD41.22843257
48EIF2AK31.19983548
49OXSR11.18122738
50MET1.18016782
51PNCK1.17506188
52MAP3K101.16672528
53PLK21.16263131
54EIF2AK21.15678351
55STK41.12890997
56TAF11.10333222
57CASK1.09784195
58CLK11.09586086
59TEC1.07798062
60STK241.07462008
61MAP4K21.02599258
62WNK41.00894897
63NLK0.99326200
64CHEK10.99152738
65ZAK0.97462903
66ATM0.97377927
67TXK0.94271111
68MAP3K90.93789495
69IRAK40.91465646
70CDK60.91339242
71FRK0.91238521
72MAP3K120.91170894
73WNK30.91094052
74STK160.88363551
75PDK20.88255706
76CDK90.87613582
77MAP2K70.87334535
78BTK0.86469508
79KIT0.86045353
80CDK80.85894479
81BCR0.85756665
82AURKA0.81721870
83RPS6KA40.81375662
84MAP3K80.79075086
85PLK30.78117048
86DYRK1B0.74748562
87RAF10.73611133
88CSNK1G30.73475822
89TNIK0.71416479
90MELK0.70819089
91PRKD20.70525998
92NEK60.69971178
93RPS6KA50.69355587
94MAP3K40.65678810
95ERBB30.65507068
96CDK20.64230692
97IRAK30.63907710
98PAK40.63870390
99CSNK1G20.63693254
100BRSK10.63496811
101TESK20.58331471
102CCNB10.57629638
103BCKDK0.57387730
104JAK30.57272043
105CDK30.56165081
106PIM20.55978169
107DYRK20.55528362
108PKN10.53727541
109ADRBK20.52446719
110FLT30.48516319
111CSNK1A1L0.47973574
112PAK10.46976424
113CDK10.46492078
114STK38L0.45815057
115MARK30.45647234
116NME10.45536484
117LIMK10.44942695
118CHUK0.44046143
119CDK190.43993969
120IRAK10.43620347
121DAPK10.42413293
122CSNK2A10.41652901
123CSNK2A20.40689425
124TGFBR10.39554707
125IKBKB0.39427369
126CSF1R0.38122439
127LYN0.37243350
128ERBB40.35814689
129BRAF0.35099300
130MAP3K60.34794756
131SYK0.32485031
132MOS0.32325931
133TAOK30.30965392
134STK380.30490592
135CAMK2A0.30235446
136INSRR0.29204310
137PRKCE0.29202697
138MAPK130.29165350
139RPS6KB10.28842692
140CSNK1D0.28632062
141CSNK1G10.28391005
142GRK10.27751289
143LCK0.27470875
144HIPK20.26595780
145MAPK110.24360131
146MAPK140.23561396
147AKT10.22145235

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.68654642
2Ribosome_Homo sapiens_hsa030103.39296192
3Fanconi anemia pathway_Homo sapiens_hsa034603.29867134
4Homologous recombination_Homo sapiens_hsa034403.19011879
5Mismatch repair_Homo sapiens_hsa034303.06695980
6Basal transcription factors_Homo sapiens_hsa030222.80297507
7Spliceosome_Homo sapiens_hsa030402.80255585
8Cell cycle_Homo sapiens_hsa041102.68537151
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58987304
10Oxidative phosphorylation_Homo sapiens_hsa001902.56199444
11Base excision repair_Homo sapiens_hsa034102.44191465
12RNA transport_Homo sapiens_hsa030132.40986571
13Nucleotide excision repair_Homo sapiens_hsa034202.28401835
14Parkinsons disease_Homo sapiens_hsa050122.20099106
15Non-homologous end-joining_Homo sapiens_hsa034502.13045192
16RNA polymerase_Homo sapiens_hsa030202.12437850
17RNA degradation_Homo sapiens_hsa030182.08387371
18Systemic lupus erythematosus_Homo sapiens_hsa053222.04174311
19Folate biosynthesis_Homo sapiens_hsa007901.94795952
20Huntingtons disease_Homo sapiens_hsa050161.86817733
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82508529
22Pyrimidine metabolism_Homo sapiens_hsa002401.81601463
23One carbon pool by folate_Homo sapiens_hsa006701.77409378
24p53 signaling pathway_Homo sapiens_hsa041151.76984837
25mRNA surveillance pathway_Homo sapiens_hsa030151.76176677
26Primary immunodeficiency_Homo sapiens_hsa053401.68935406
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68220085
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.52012005
29Regulation of autophagy_Homo sapiens_hsa041401.47575462
30Herpes simplex infection_Homo sapiens_hsa051681.40982279
31Propanoate metabolism_Homo sapiens_hsa006401.37361684
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.32269745
33Alzheimers disease_Homo sapiens_hsa050101.30973482
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28729189
35Antigen processing and presentation_Homo sapiens_hsa046121.27234408
36Viral carcinogenesis_Homo sapiens_hsa052031.27088918
37Caffeine metabolism_Homo sapiens_hsa002321.26766254
38Purine metabolism_Homo sapiens_hsa002301.22234916
39Steroid biosynthesis_Homo sapiens_hsa001001.19763574
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17057576
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17016294
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10197689
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.09970146
44Fatty acid elongation_Homo sapiens_hsa000621.08788814
45Oocyte meiosis_Homo sapiens_hsa041141.07667618
46Measles_Homo sapiens_hsa051621.07266777
47Alcoholism_Homo sapiens_hsa050341.07211578
48HTLV-I infection_Homo sapiens_hsa051661.06887529
49Epstein-Barr virus infection_Homo sapiens_hsa051691.05883168
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03261448
51Olfactory transduction_Homo sapiens_hsa047401.01166508
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99632552
53Proteasome_Homo sapiens_hsa030500.96861870
54Hematopoietic cell lineage_Homo sapiens_hsa046400.94132633
55B cell receptor signaling pathway_Homo sapiens_hsa046620.87930253
56Cardiac muscle contraction_Homo sapiens_hsa042600.87616975
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86949898
58Phototransduction_Homo sapiens_hsa047440.86843898
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86165781
60Nicotine addiction_Homo sapiens_hsa050330.82995823
61Collecting duct acid secretion_Homo sapiens_hsa049660.82506861
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82377842
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81946944
64MicroRNAs in cancer_Homo sapiens_hsa052060.80871078
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79657230
66Sulfur metabolism_Homo sapiens_hsa009200.78691567
67Basal cell carcinoma_Homo sapiens_hsa052170.77707175
68Pyruvate metabolism_Homo sapiens_hsa006200.77098381
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76811351
70Hepatitis B_Homo sapiens_hsa051610.76295904
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.76044465
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.75565357
73Small cell lung cancer_Homo sapiens_hsa052220.75076506
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74754104
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74406636
76Notch signaling pathway_Homo sapiens_hsa043300.72969988
77Butanoate metabolism_Homo sapiens_hsa006500.71839654
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71024300
79Acute myeloid leukemia_Homo sapiens_hsa052210.70053517
80Colorectal cancer_Homo sapiens_hsa052100.68621567
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67539366
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65405362
83Metabolic pathways_Homo sapiens_hsa011000.63797521
84Thyroid cancer_Homo sapiens_hsa052160.63771890
85T cell receptor signaling pathway_Homo sapiens_hsa046600.63184503
86Vitamin B6 metabolism_Homo sapiens_hsa007500.62589220
87Apoptosis_Homo sapiens_hsa042100.62023135
88Wnt signaling pathway_Homo sapiens_hsa043100.61492522
89Taste transduction_Homo sapiens_hsa047420.59182681
90Allograft rejection_Homo sapiens_hsa053300.58967094
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58641540
92Glutathione metabolism_Homo sapiens_hsa004800.58475781
93Influenza A_Homo sapiens_hsa051640.57927413
94Protein export_Homo sapiens_hsa030600.56165414
95Sulfur relay system_Homo sapiens_hsa041220.55926761
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55518060
97Other glycan degradation_Homo sapiens_hsa005110.55511542
98Graft-versus-host disease_Homo sapiens_hsa053320.53941935
99N-Glycan biosynthesis_Homo sapiens_hsa005100.51302849
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.51149054
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.50059037
102Legionellosis_Homo sapiens_hsa051340.48720378
103Chronic myeloid leukemia_Homo sapiens_hsa052200.47986020
104Pathways in cancer_Homo sapiens_hsa052000.46196976
105Peroxisome_Homo sapiens_hsa041460.46109581
106Leishmaniasis_Homo sapiens_hsa051400.45339094
107Selenocompound metabolism_Homo sapiens_hsa004500.45014847
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44932347
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44304576
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44222325
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44086426
112TGF-beta signaling pathway_Homo sapiens_hsa043500.43318711
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42839511
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42816049
115Asthma_Homo sapiens_hsa053100.42361700
116Prostate cancer_Homo sapiens_hsa052150.37780218
117Autoimmune thyroid disease_Homo sapiens_hsa053200.35913711
118Osteoclast differentiation_Homo sapiens_hsa043800.35872085
119TNF signaling pathway_Homo sapiens_hsa046680.35487116
120Shigellosis_Homo sapiens_hsa051310.35014482
121Arachidonic acid metabolism_Homo sapiens_hsa005900.34667895
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34453049
123Malaria_Homo sapiens_hsa051440.34022115
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33448616
125Hedgehog signaling pathway_Homo sapiens_hsa043400.32704740
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32437679
127Toxoplasmosis_Homo sapiens_hsa051450.31385356
128FoxO signaling pathway_Homo sapiens_hsa040680.31005598
129Tryptophan metabolism_Homo sapiens_hsa003800.29178281
130Chemical carcinogenesis_Homo sapiens_hsa052040.27857096
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27766482
132Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27697321
133Hippo signaling pathway_Homo sapiens_hsa043900.27519740
134Circadian rhythm_Homo sapiens_hsa047100.26550221
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26460704
136Nitrogen metabolism_Homo sapiens_hsa009100.26456115
137Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25995002
138Cyanoamino acid metabolism_Homo sapiens_hsa004600.25226300
139Retinol metabolism_Homo sapiens_hsa008300.25139073
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.24190289
141Biosynthesis of amino acids_Homo sapiens_hsa012300.24012101
142Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23994112
143Linoleic acid metabolism_Homo sapiens_hsa005910.23971998
144Glucagon signaling pathway_Homo sapiens_hsa049220.23457054
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23186147
146Dorso-ventral axis formation_Homo sapiens_hsa043200.22673178
147Pentose phosphate pathway_Homo sapiens_hsa000300.22584418
148Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22304532
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.22271994
150Arginine and proline metabolism_Homo sapiens_hsa003300.22127756
151GABAergic synapse_Homo sapiens_hsa047270.20446008
152Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20281907
153beta-Alanine metabolism_Homo sapiens_hsa004100.18624113
154Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18529049
155Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15290135
156Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15177272
157Morphine addiction_Homo sapiens_hsa050320.15043571
158Ether lipid metabolism_Homo sapiens_hsa005650.14636262

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