IAH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.96646478
2L-phenylalanine catabolic process (GO:0006559)6.96646478
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.70851015
4L-phenylalanine metabolic process (GO:0006558)6.70851015
5aromatic amino acid family catabolic process (GO:0009074)6.31597696
6glyoxylate metabolic process (GO:0046487)5.72536947
7indole-containing compound catabolic process (GO:0042436)5.66255047
8indolalkylamine catabolic process (GO:0046218)5.66255047
9tryptophan catabolic process (GO:0006569)5.66255047
10tryptophan metabolic process (GO:0006568)5.38785833
11kynurenine metabolic process (GO:0070189)5.37612471
12cysteine metabolic process (GO:0006534)5.37384720
13bile acid biosynthetic process (GO:0006699)5.20350373
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.18717719
15sulfur amino acid catabolic process (GO:0000098)5.11583665
16DNA deamination (GO:0045006)5.02185811
17urea cycle (GO:0000050)4.81804831
18urea metabolic process (GO:0019627)4.81804831
19complement activation, alternative pathway (GO:0006957)4.76570803
20response to pheromone (GO:0019236)4.70689058
21platelet dense granule organization (GO:0060155)4.67550382
22lysine catabolic process (GO:0006554)4.64172519
23lysine metabolic process (GO:0006553)4.64172519
24peptidyl-glutamic acid carboxylation (GO:0017187)4.62031751
25protein carboxylation (GO:0018214)4.62031751
26homocysteine metabolic process (GO:0050667)4.61290309
27aromatic amino acid family metabolic process (GO:0009072)4.60406383
28high-density lipoprotein particle remodeling (GO:0034375)4.59524692
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.59192592
30alpha-linolenic acid metabolic process (GO:0036109)4.57510154
31nitrogen cycle metabolic process (GO:0071941)4.53945891
32aldehyde catabolic process (GO:0046185)4.50470923
33serine family amino acid catabolic process (GO:0009071)4.50166915
34negative regulation of fibrinolysis (GO:0051918)4.40088733
35regulation of protein activation cascade (GO:2000257)4.38470756
36bile acid metabolic process (GO:0008206)4.37560235
37regulation of cholesterol esterification (GO:0010872)4.32442001
38tyrosine metabolic process (GO:0006570)4.32040942
39coenzyme catabolic process (GO:0009109)4.25192211
40regulation of fibrinolysis (GO:0051917)4.23071004
41alpha-amino acid catabolic process (GO:1901606)4.17865175
42regulation of triglyceride catabolic process (GO:0010896)4.14141184
43regulation of complement activation (GO:0030449)4.13390229
44amino-acid betaine metabolic process (GO:0006577)4.12708744
45cellular glucuronidation (GO:0052695)4.11890670
46protein complex biogenesis (GO:0070271)4.11501813
47respiratory chain complex IV assembly (GO:0008535)4.08925183
48urate metabolic process (GO:0046415)4.04194850
49cofactor catabolic process (GO:0051187)4.02973992
50plasma lipoprotein particle remodeling (GO:0034369)4.02876004
51protein-lipid complex remodeling (GO:0034368)4.02876004
52macromolecular complex remodeling (GO:0034367)4.02876004
53amine catabolic process (GO:0009310)4.01049139
54cellular biogenic amine catabolic process (GO:0042402)4.01049139
55indolalkylamine metabolic process (GO:0006586)4.00639822
56drug transmembrane transport (GO:0006855)3.99095094
57serine family amino acid metabolic process (GO:0009069)3.98704898
58reverse cholesterol transport (GO:0043691)3.97790347
59proteasome assembly (GO:0043248)3.95920798
60benzene-containing compound metabolic process (GO:0042537)3.94511868
61uronic acid metabolic process (GO:0006063)3.92594912
62glucuronate metabolic process (GO:0019585)3.92594912
63cellular amino acid catabolic process (GO:0009063)3.91527727
64plasma lipoprotein particle clearance (GO:0034381)3.88586248
65negative regulation of sterol transport (GO:0032372)3.87912902
66negative regulation of cholesterol transport (GO:0032375)3.87912902
67triglyceride homeostasis (GO:0070328)3.86305607
68acylglycerol homeostasis (GO:0055090)3.86305607
69serine family amino acid biosynthetic process (GO:0009070)3.85138667
70cellular ketone body metabolic process (GO:0046950)3.81410021
71glycine metabolic process (GO:0006544)3.81215168
72cytochrome complex assembly (GO:0017004)3.78981284
73phospholipid efflux (GO:0033700)3.78496985
74protein neddylation (GO:0045116)3.76612271
75cellular modified amino acid catabolic process (GO:0042219)3.75096434
76mitochondrial respiratory chain complex assembly (GO:0033108)3.73304743
77establishment of protein localization to mitochondrial membrane (GO:0090151)3.71481034
78mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.68943196
79bile acid and bile salt transport (GO:0015721)3.68433685
80behavioral response to nicotine (GO:0035095)3.67551033
81water-soluble vitamin biosynthetic process (GO:0042364)3.67420702
822-oxoglutarate metabolic process (GO:0006103)3.66417444
83cytidine metabolic process (GO:0046087)3.65110856
84cytidine catabolic process (GO:0006216)3.65110856
85cytidine deamination (GO:0009972)3.65110856
86ethanol oxidation (GO:0006069)3.63046851
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.62173123
88mitochondrial respiratory chain complex I assembly (GO:0032981)3.62173123
89NADH dehydrogenase complex assembly (GO:0010257)3.62173123
90arginine metabolic process (GO:0006525)3.61751008
91short-chain fatty acid metabolic process (GO:0046459)3.59916130
92drug catabolic process (GO:0042737)3.59542314
93glutamate metabolic process (GO:0006536)3.57416471
94valine metabolic process (GO:0006573)3.57251777
95low-density lipoprotein particle remodeling (GO:0034374)3.55578535
96carboxylic acid catabolic process (GO:0046395)3.54732281
97organic acid catabolic process (GO:0016054)3.54732281
98cullin deneddylation (GO:0010388)3.54577448
99cholesterol efflux (GO:0033344)3.54410477
100DNA double-strand break processing (GO:0000729)3.53587794
101protein K6-linked ubiquitination (GO:0085020)3.53489169
102fibrinolysis (GO:0042730)3.52887397
103NAD biosynthetic process (GO:0009435)3.52872970
104acetyl-CoA metabolic process (GO:0006084)3.52370049
105detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.49177635
106pyridine nucleotide biosynthetic process (GO:0019363)3.48069965
107nicotinamide nucleotide biosynthetic process (GO:0019359)3.48069965
108imidazole-containing compound metabolic process (GO:0052803)3.46296135
109drug transport (GO:0015893)3.42889944
110fatty acid beta-oxidation (GO:0006635)3.42317737
111replication fork processing (GO:0031297)3.41728755
112aspartate family amino acid catabolic process (GO:0009068)3.40163492
113fatty acid oxidation (GO:0019395)3.39705322
114mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.36930426
115response to nitrosative stress (GO:0051409)3.36852285
116drug metabolic process (GO:0017144)3.36452028
117cholesterol homeostasis (GO:0042632)3.34318691
118lipid oxidation (GO:0034440)3.34189241
119L-fucose catabolic process (GO:0042355)3.33687514
120fucose catabolic process (GO:0019317)3.33687514
121L-fucose metabolic process (GO:0042354)3.33687514
122monocarboxylic acid catabolic process (GO:0072329)3.33402336
123flavonoid metabolic process (GO:0009812)3.30865191
124protein deneddylation (GO:0000338)3.30710041
125ketone body metabolic process (GO:1902224)3.29889565
126sterol homeostasis (GO:0055092)3.29172738
127blood coagulation, intrinsic pathway (GO:0007597)3.26571409
128nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.26373569
129fatty acid catabolic process (GO:0009062)3.25845569
130ATP synthesis coupled proton transport (GO:0015986)3.25257065
131energy coupled proton transport, down electrochemical gradient (GO:0015985)3.25257065
132plasma lipoprotein particle assembly (GO:0034377)3.23341484
133exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19918567
134pyrimidine ribonucleoside catabolic process (GO:0046133)3.05739195
135protein-cofactor linkage (GO:0018065)3.05053016
136keratinocyte development (GO:0003334)3.01514682
137regulation of meiosis I (GO:0060631)3.00576465
138regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.99805799
139electron transport chain (GO:0022900)2.98908323
140intraciliary transport (GO:0042073)2.98792267
141respiratory electron transport chain (GO:0022904)2.95778025
142protein localization to cilium (GO:0061512)2.95489470
143RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.89964394
144tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.89964394
145anterograde synaptic vesicle transport (GO:0048490)2.89447018
146mannosylation (GO:0097502)2.86288661
147preassembly of GPI anchor in ER membrane (GO:0016254)2.85443416
148cornea development in camera-type eye (GO:0061303)2.82733679
149adenosine metabolic process (GO:0046085)2.80783906
150L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79901995
151RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.79561464
152protein polyglutamylation (GO:0018095)2.79495074
153cilium morphogenesis (GO:0060271)2.76529012
154axoneme assembly (GO:0035082)2.76525857
155piRNA metabolic process (GO:0034587)2.69233441
156regulation of hexokinase activity (GO:1903299)2.65480641
157regulation of glucokinase activity (GO:0033131)2.65480641
158GPI anchor metabolic process (GO:0006505)2.63046403
159regulation of cellular amino acid metabolic process (GO:0006521)2.61293166
160recombinational repair (GO:0000725)2.60858693
161regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.60064001
162amino acid salvage (GO:0043102)2.59562391
163L-methionine salvage (GO:0071267)2.59562391
164L-methionine biosynthetic process (GO:0071265)2.59562391
165double-strand break repair via homologous recombination (GO:0000724)2.57832953
166C-terminal protein lipidation (GO:0006501)2.57659483
167S-adenosylmethionine metabolic process (GO:0046500)2.57235244
168chaperone-mediated protein transport (GO:0072321)2.55747968
169pseudouridine synthesis (GO:0001522)2.54583279
170branched-chain amino acid catabolic process (GO:0009083)2.53938707
171regulation of cilium movement (GO:0003352)2.53798383
172DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.52633218
173adaptation of signaling pathway (GO:0023058)2.52346779
174dopamine transport (GO:0015872)2.51121222
175protein prenylation (GO:0018342)2.50068866
176prenylation (GO:0097354)2.50068866
177synapsis (GO:0007129)2.50067094
178xenobiotic catabolic process (GO:0042178)2.49965704
179ubiquinone biosynthetic process (GO:0006744)2.48963210
180detection of light stimulus involved in sensory perception (GO:0050962)2.48379636
181detection of light stimulus involved in visual perception (GO:0050908)2.48379636
182C-terminal protein amino acid modification (GO:0018410)2.47210057
183negative regulation of telomere maintenance (GO:0032205)2.46893371
184signal peptide processing (GO:0006465)2.46304916
185behavioral response to ethanol (GO:0048149)2.44357228
186retinal cone cell development (GO:0046549)2.43489197
187epithelial cilium movement (GO:0003351)2.42945589
188signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.42169026
189signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.42169026
190signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.42169026

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.17808168
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.24951329
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.10496546
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.50553031
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.39290711
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.84130679
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.32136207
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.73576411
9ZNF274_21170338_ChIP-Seq_K562_Hela3.21330173
10VDR_22108803_ChIP-Seq_LS180_Human3.04995067
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.97106572
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.94582051
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.84591032
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79318891
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.69947367
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61581314
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44673527
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40409429
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.35830860
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35516989
21GBX2_23144817_ChIP-Seq_PC3_Human2.34890366
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.32596694
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.30238440
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21365574
25EWS_26573619_Chip-Seq_HEK293_Human2.17913175
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12932008
27P300_19829295_ChIP-Seq_ESCs_Human2.11285584
28ELK1_19687146_ChIP-ChIP_HELA_Human2.11145412
29FUS_26573619_Chip-Seq_HEK293_Human2.06707033
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.06678042
31GATA1_22025678_ChIP-Seq_K562_Human2.05355826
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2426183
33IGF1R_20145208_ChIP-Seq_DFB_Human1.99717889
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.96500269
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.90566575
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87934646
37TAF15_26573619_Chip-Seq_HEK293_Human1.83195558
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.82688535
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.82295751
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78671483
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78543524
42TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.77328985
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76437260
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75630116
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70005222
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.69908914
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67650692
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65764642
49VDR_23849224_ChIP-Seq_CD4+_Human1.64400563
50ER_23166858_ChIP-Seq_MCF-7_Human1.63470610
51BCAT_22108803_ChIP-Seq_LS180_Human1.61028849
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.57927778
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56828512
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55577767
55NANOG_19829295_ChIP-Seq_ESCs_Human1.55051884
56SOX2_19829295_ChIP-Seq_ESCs_Human1.55051884
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54458866
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53349270
59MYC_18940864_ChIP-ChIP_HL60_Human1.52202791
60CLOCK_20551151_ChIP-Seq_293T_Human1.51150479
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50668911
62TP53_22573176_ChIP-Seq_HFKS_Human1.50211448
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50143919
64* CBP_20019798_ChIP-Seq_JUKART_Human1.48013133
65* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48013133
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.46506108
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45847518
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44356963
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.43510606
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41447913
71AR_25329375_ChIP-Seq_VCAP_Human1.41070520
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40874946
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.39719748
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39340759
75SMAD4_21799915_ChIP-Seq_A2780_Human1.38284439
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36611255
77EZH2_22144423_ChIP-Seq_EOC_Human1.36091960
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34354416
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32123241
80* CRX_20693478_ChIP-Seq_RETINA_Mouse1.30447353
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29725932
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.29631720
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29631720
84IRF1_19129219_ChIP-ChIP_H3396_Human1.28246027
85TCF4_22108803_ChIP-Seq_LS180_Human1.26733830
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26002906
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23712786
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.23213772
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23159423
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.23054415
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22229586
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21294069
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20950603
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20891793
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18500558
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17940079
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16377861
98TCF4_23295773_ChIP-Seq_U87_Human1.16036337
99P53_22387025_ChIP-Seq_ESCs_Mouse1.16003516
100STAT3_23295773_ChIP-Seq_U87_Human1.15771068
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15669172
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15251815
103PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14930093
104CDX2_22108803_ChIP-Seq_LS180_Human1.14915000
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14640256
106ETS1_20019798_ChIP-Seq_JURKAT_Human1.12965994
107HNF4A_19822575_ChIP-Seq_HepG2_Human1.11862277
108STAT3_18555785_Chip-Seq_ESCs_Mouse1.09433551
109FOXA2_19822575_ChIP-Seq_HepG2_Human1.09325274
110SMAD4_21741376_ChIP-Seq_EPCs_Human1.08276634
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.08258564
112POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07927023
113* FOXP3_21729870_ChIP-Seq_TREG_Human1.06875304
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06405100
115NCOR_22424771_ChIP-Seq_293T_Human1.05883556
116PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05442004
117IRF8_27001747_Chip-Seq_BMDM_Mouse1.05129938
118SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04592895
119SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04468442
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03878153
121RUNX2_22187159_ChIP-Seq_PCA_Human1.03540519
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03329107
123GATA4_25053715_ChIP-Seq_YYC3_Human1.03309028
124OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02780941
125FOXH1_21741376_ChIP-Seq_EPCs_Human1.02517163
126AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02185107
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01976044
128* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01944837
129* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01448520
130E2F1_18555785_Chip-Seq_ESCs_Mouse1.01344216
131STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99203741
132SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98682535
133NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98602061
134ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95617202
135HTT_18923047_ChIP-ChIP_STHdh_Human0.95130668
136ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94481208
137* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91829472
138E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.90400336
139MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89488156
140PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84920726
141KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83122648
142SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79692202
143BRD4_27068464_Chip-Seq_AML-cells_Mouse0.77402750
144GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76802428
145RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.75798830
146NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74774676
147NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74774676
148SOX2_20726797_ChIP-Seq_SW620_Human0.74230479
149ESR1_21235772_ChIP-Seq_MCF-7_Human0.73601465
150EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.73536446
151CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73312036
152CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72479485
153SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72341818
154CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72190900
155BP1_19119308_ChIP-ChIP_Hs578T_Human0.71511180
156SRF_21415370_ChIP-Seq_HL-1_Mouse0.71283298
157* CEBPB_22108803_ChIP-Seq_LS180_Human0.70339942
158CDX2_20551321_ChIP-Seq_CACO-2_Human0.70221048
159BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68964574
160AR_20517297_ChIP-Seq_VCAP_Human0.68409108
161ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.68183070
162EGR1_19032775_ChIP-ChIP_M12_Human0.66359321
163CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.66096713
164TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65452627
165SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.65425250
166NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64021021
167RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62490035
168PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.61829822
169ZNF263_19887448_ChIP-Seq_K562_Human0.61306199
170CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.60702254
171CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.60296566
172PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.60141465
173RARA_24833708_ChIP-Seq_LIVER_Mouse0.59962536
174CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.59921005
175ESR2_21235772_ChIP-Seq_MCF-7_Human0.59658171
176P63_26484246_Chip-Seq_KERATINOCYTES_Human0.59515228
177FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.59504886
178PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.58829036
179GATA1_22383799_ChIP-Seq_G1ME_Mouse0.57702128
180TRIM28_21343339_ChIP-Seq_HEK293_Human0.57493051
181TP63_17297297_ChIP-ChIP_HaCaT_Human0.56486942
182LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.55685973
183FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.55602934
184PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.55016824
185LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.54503161
186FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.54291657
187LXR_22292898_ChIP-Seq_THP-1_Human0.53943588
188GATA2_22383799_ChIP-Seq_G1ME_Mouse0.53447241
189GATA6_25053715_ChIP-Seq_YYC3_Human0.53223413
190SOX2_18692474_ChIP-Seq_MEFs_Mouse0.52378357
191PPAR_26484153_Chip-Seq_NCI-H1993_Human0.51852361
192SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.51590988
193TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.51272904
194AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.50312994
195* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.49937412

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.06451574
2MP0005360_urolithiasis6.85505932
3MP0005085_abnormal_gallbladder_physiolo5.44103066
4MP0005365_abnormal_bile_salt5.30422846
5MP0008875_abnormal_xenobiotic_pharmacok4.39783265
6MP0003806_abnormal_nucleotide_metabolis3.73617126
7MP0003252_abnormal_bile_duct3.59320738
8MP0002837_dystrophic_cardiac_calcinosis3.33528917
9MP0005083_abnormal_biliary_tract3.29677160
10MP0002102_abnormal_ear_morphology3.11943152
11MP0003195_calcinosis3.03318774
12MP0000372_irregular_coat_pigmentation2.99666995
13MP0005332_abnormal_amino_acid2.97291319
14MP0010329_abnormal_lipoprotein_level2.92648451
15MP0009840_abnormal_foam_cell2.85743857
16MP0002138_abnormal_hepatobiliary_system2.71280019
17MP0006054_spinal_hemorrhage2.55274540
18MP0001666_abnormal_nutrient_absorption2.44156399
19MP0008877_abnormal_DNA_methylation2.41344744
20MP0005646_abnormal_pituitary_gland2.30058416
21MP0004019_abnormal_vitamin_homeostasis2.29090377
22MP0006072_abnormal_retinal_apoptosis2.25753068
23MP0005551_abnormal_eye_electrophysiolog2.23391676
24MP0003191_abnormal_cellular_cholesterol2.20864913
25MP0003186_abnormal_redox_activity2.11565266
26MP0005075_abnormal_melanosome_morpholog2.01890716
27MP0000609_abnormal_liver_physiology1.89419717
28MP0005253_abnormal_eye_physiology1.85313478
29MP0005319_abnormal_enzyme/_coenzyme1.85283578
30MP0002938_white_spotting1.85097511
31MP0006292_abnormal_olfactory_placode1.83831411
32MP0002118_abnormal_lipid_homeostasis1.81911443
33MP0009643_abnormal_urine_homeostasis1.76490344
34MP0001984_abnormal_olfaction1.76001346
35MP0005584_abnormal_enzyme/coenzyme_acti1.72371171
36MP0001764_abnormal_homeostasis1.66008658
37MP0000569_abnormal_digit_pigmentation1.65400308
38MP0003718_maternal_effect1.65392537
39MP0000427_abnormal_hair_cycle1.63108537
40MP0001968_abnormal_touch/_nociception1.62970066
41MP0002638_abnormal_pupillary_reflex1.59277776
42MP0005174_abnormal_tail_pigmentation1.57976292
43MP0003880_abnormal_central_pattern1.57352697
44MP0002736_abnormal_nociception_after1.55885094
45MP0003787_abnormal_imprinting1.53761321
46MP0008872_abnormal_physiological_respon1.52867238
47MP0009046_muscle_twitch1.51702759
48MP0002234_abnormal_pharynx_morphology1.49621817
49MP0003950_abnormal_plasma_membrane1.49023226
50MP0005451_abnormal_body_composition1.48731900
51MP0001485_abnormal_pinna_reflex1.48460610
52MP0004147_increased_porphyrin_level1.47262323
53MP0010386_abnormal_urinary_bladder1.45786637
54MP0009745_abnormal_behavioral_response1.44866854
55MP0003136_yellow_coat_color1.44282711
56MP0000516_abnormal_urinary_system1.44186513
57MP0005367_renal/urinary_system_phenotyp1.44186513
58MP0008789_abnormal_olfactory_epithelium1.42696559
59MP0003786_premature_aging1.41956591
60MP0003724_increased_susceptibility_to1.41808627
61MP0003868_abnormal_feces_composition1.34463956
62MP0004142_abnormal_muscle_tone1.33697470
63MP0009764_decreased_sensitivity_to1.32728410
64MP0005636_abnormal_mineral_homeostasis1.32263644
65MP0005084_abnormal_gallbladder_morpholo1.29851969
66MP0000631_abnormal_neuroendocrine_gland1.29363369
67MP0008469_abnormal_protein_level1.28609051
68MP0002751_abnormal_autonomic_nervous1.28377344
69MP0001501_abnormal_sleep_pattern1.26047635
70MP0002876_abnormal_thyroid_physiology1.25905037
71MP0002090_abnormal_vision1.24456066
72MP0008058_abnormal_DNA_repair1.24346061
73MP0003436_decreased_susceptibility_to1.22463540
74MP0002272_abnormal_nervous_system1.22407641
75MP0005220_abnormal_exocrine_pancreas1.20687727
76MP0005645_abnormal_hypothalamus_physiol1.20545447
77MP0005058_abnormal_lysosome_morphology1.20141685
78MP0009697_abnormal_copulation1.19385450
79MP0001986_abnormal_taste_sensitivity1.18755713
80MP0005389_reproductive_system_phenotype1.18679245
81MP0003183_abnormal_peptide_metabolism1.18439028
82MP0003656_abnormal_erythrocyte_physiolo1.17867860
83MP0005408_hypopigmentation1.16317704
84MP0002095_abnormal_skin_pigmentation1.15918460
85MP0002653_abnormal_ependyma_morphology1.13682178
86MP0001756_abnormal_urination1.12787864
87MP0004215_abnormal_myocardial_fiber1.12347753
88MP0000598_abnormal_liver_morphology1.12132408
89MP0003646_muscle_fatigue1.08589814
90MP0002254_reproductive_system_inflammat1.08064529
91MP0004782_abnormal_surfactant_physiolog1.07497875
92MP0001905_abnormal_dopamine_level1.06523429
93MP0006276_abnormal_autonomic_nervous1.06520582
94MP0003011_delayed_dark_adaptation1.06065351
95MP0009763_increased_sensitivity_to1.05704689
96MP0000015_abnormal_ear_pigmentation1.03646326
97MP0001835_abnormal_antigen_presentation1.02755310
98MP0000604_amyloidosis1.02288803
99MP0002160_abnormal_reproductive_system1.00558360
100MP0001486_abnormal_startle_reflex1.00012769
101MP0002282_abnormal_trachea_morphology0.99984960
102MP0004043_abnormal_pH_regulation0.99875348
103MP0002136_abnormal_kidney_physiology0.99390258
104MP0003137_abnormal_impulse_conducting0.99297435
105MP0000647_abnormal_sebaceous_gland0.98632636
106MP0005671_abnormal_response_to0.98022831
107MP0004885_abnormal_endolymph0.97598972
108MP0008995_early_reproductive_senescence0.97535410
109MP0002163_abnormal_gland_morphology0.97522826
110MP0001529_abnormal_vocalization0.97438844
111MP0005410_abnormal_fertilization0.95682185
112MP0003121_genomic_imprinting0.95335825
113MP0006036_abnormal_mitochondrial_physio0.94669517
114MP0006082_CNS_inflammation0.94362872
115MP0009785_altered_susceptibility_to0.94285953
116MP0005195_abnormal_posterior_eye0.91420419
117MP0005379_endocrine/exocrine_gland_phen0.90586630
118MP0003283_abnormal_digestive_organ0.90478666
119MP0009642_abnormal_blood_homeostasis0.88763456
120MP0000685_abnormal_immune_system0.88376615
121MP0001324_abnormal_eye_pigmentation0.87391526
122MP0001929_abnormal_gametogenesis0.86716300
123MP0005670_abnormal_white_adipose0.85197438
124MP0005171_absent_coat_pigmentation0.85176067
125MP0008775_abnormal_heart_ventricle0.83505736
126MP0004133_heterotaxia0.82324842
127MP0005647_abnormal_sex_gland0.82156239
128MP0003705_abnormal_hypodermis_morpholog0.81030661
129MP0002557_abnormal_social/conspecific_i0.81028867
130MP0000653_abnormal_sex_gland0.80091055
131MP0001119_abnormal_female_reproductive0.79545235
132MP0005376_homeostasis/metabolism_phenot0.78749592
133MP0002277_abnormal_respiratory_mucosa0.78467408
134MP0009780_abnormal_chondrocyte_physiolo0.78252278
135MP0001853_heart_inflammation0.78144911
136MP0005025_abnormal_response_to0.77931068
137MP0002419_abnormal_innate_immunity0.77861698
138MP0002210_abnormal_sex_determination0.77817558
139MP0001970_abnormal_pain_threshold0.77110108
140MP0000639_abnormal_adrenal_gland0.77106056
141MP0005464_abnormal_platelet_physiology0.76161568
142MP0001845_abnormal_inflammatory_respons0.75615305
143MP0009765_abnormal_xenobiotic_induced0.73431275
144MP0003638_abnormal_response/metabolism_0.65981749
145MP0002078_abnormal_glucose_homeostasis0.64780146
146MP0009379_abnormal_foot_pigmentation0.64679073
147MP0002928_abnormal_bile_duct0.63568972
148MP0003959_abnormal_lean_body0.63467992
149MP0010368_abnormal_lymphatic_system0.62419437
150MP0005334_abnormal_fat_pad0.62171419
151MP0005535_abnormal_body_temperature0.61926820
152MP0001661_extended_life_span0.61209195
153MP0002148_abnormal_hypersensitivity_rea0.59657585
154MP0002971_abnormal_brown_adipose0.59452723
155MP0001790_abnormal_immune_system0.59318655
156MP0005387_immune_system_phenotype0.59318655
157MP0002132_abnormal_respiratory_system0.57385617
158MP0001765_abnormal_ion_homeostasis0.56113191
159MP0004130_abnormal_muscle_cell0.55821181
160MP0005266_abnormal_metabolism0.54437292
161MP0003690_abnormal_glial_cell0.52744296
162MP0002166_altered_tumor_susceptibility0.52270070
163MP0005395_other_phenotype0.51937310
164MP0003075_altered_response_to0.50797714
165MP0001533_abnormal_skeleton_physiology0.50640939
166MP0005164_abnormal_response_to0.49964815
167MP0005166_decreased_susceptibility_to0.48691515
168MP0005000_abnormal_immune_tolerance0.48289131
169MP0008260_abnormal_autophagy0.47939033
170MP0002168_other_aberrant_phenotype0.47310186
171MP0000249_abnormal_blood_vessel0.46073241
172MP0000230_abnormal_systemic_arterial0.45272187
173MP0001800_abnormal_humoral_immune0.44651319
174MP0002135_abnormal_kidney_morphology0.44098496
175MP0002295_abnormal_pulmonary_circulatio0.43465251
176MP0008873_increased_physiological_sensi0.43155271
177MP0009384_cardiac_valve_regurgitation0.42958530
178MP0000538_abnormal_urinary_bladder0.42950967

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.51559273
2Intrahepatic cholestasis (HP:0001406)5.71534001
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.45899780
4Deep venous thrombosis (HP:0002625)5.37190011
5Xanthomatosis (HP:0000991)5.18171172
6Prolonged partial thromboplastin time (HP:0003645)5.09119999
7Hypobetalipoproteinemia (HP:0003563)4.87183872
8Complement deficiency (HP:0004431)4.39239537
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.36230798
10Hyperlipoproteinemia (HP:0010980)4.18974275
11Hyperammonemia (HP:0001987)4.04875440
12Pancreatic cysts (HP:0001737)4.03196504
13Hyperglycinuria (HP:0003108)3.96485937
14Joint hemorrhage (HP:0005261)3.96153708
15True hermaphroditism (HP:0010459)3.89747481
16Acute necrotizing encephalopathy (HP:0006965)3.85382789
17Abnormality of aspartate family amino acid metabolism (HP:0010899)3.83953695
18Ketosis (HP:0001946)3.82617038
19Pancreatic fibrosis (HP:0100732)3.81696047
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.75781607
21Hypoglycemic coma (HP:0001325)3.73450314
22Abnormality of serine family amino acid metabolism (HP:0010894)3.70525293
23Abnormality of glycine metabolism (HP:0010895)3.70525293
24Molar tooth sign on MRI (HP:0002419)3.70397283
25Abnormality of midbrain morphology (HP:0002418)3.70397283
26Hyperglycinemia (HP:0002154)3.66212922
27Progressive macrocephaly (HP:0004481)3.63840679
28Fat malabsorption (HP:0002630)3.60452858
29Abnormality of the common coagulation pathway (HP:0010990)3.60060585
30Abnormality of fatty-acid metabolism (HP:0004359)3.57629448
31Abnormality of methionine metabolism (HP:0010901)3.57583374
32Mitochondrial inheritance (HP:0001427)3.55295920
33Hypolipoproteinemia (HP:0010981)3.52081139
34Epidermoid cyst (HP:0200040)3.49069525
35Increased CSF lactate (HP:0002490)3.41403765
36Nephronophthisis (HP:0000090)3.38146854
37Abnormality of complement system (HP:0005339)3.37027510
38Abnormality of pyrimidine metabolism (HP:0004353)3.31632908
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.29238386
40Abnormal mitochondria in muscle tissue (HP:0008316)3.26065238
41Gout (HP:0001997)3.23555128
42Congenital stationary night blindness (HP:0007642)3.21172602
43Delayed CNS myelination (HP:0002188)3.20761035
44Abnormality of nucleobase metabolism (HP:0010932)3.17033234
453-Methylglutaconic aciduria (HP:0003535)3.15389878
46Medial flaring of the eyebrow (HP:0010747)3.11790592
47Abnormality of purine metabolism (HP:0004352)3.09733397
48Recurrent gram-negative bacterial infections (HP:0005420)3.07210660
49Systemic lupus erythematosus (HP:0002725)3.06531744
50Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.02085291
51Ketoacidosis (HP:0001993)3.00858556
52Hepatocellular necrosis (HP:0001404)2.97962296
53Dicarboxylic aciduria (HP:0003215)2.96157843
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.96157843
55Generalized aminoaciduria (HP:0002909)2.95793492
56Steatorrhea (HP:0002570)2.95317965
57Hypoalphalipoproteinemia (HP:0003233)2.95251559
58Abnormality of the intrinsic pathway (HP:0010989)2.94108547
59Hypothermia (HP:0002045)2.93291061
60Abnormality of the renal cortex (HP:0011035)2.93193321
61Conjugated hyperbilirubinemia (HP:0002908)2.91634878
62Abnormality of the renal medulla (HP:0100957)2.90461502
63Hyperbilirubinemia (HP:0002904)2.84019638
64Hypercholesterolemia (HP:0003124)2.82722871
65Cerebral edema (HP:0002181)2.82082115
66Lethargy (HP:0001254)2.80388580
67Proximal tubulopathy (HP:0000114)2.71638760
68Abnormality of serum amino acid levels (HP:0003112)2.67478033
69Metabolic acidosis (HP:0001942)2.63327243
70Hepatocellular carcinoma (HP:0001402)2.61348336
71Increased hepatocellular lipid droplets (HP:0006565)2.61259178
72Methylmalonic acidemia (HP:0002912)2.61157668
73Aplasia/Hypoplasia of the tongue (HP:0010295)2.59088904
74Vascular calcification (HP:0004934)2.57266703
75Abnormal rod and cone electroretinograms (HP:0008323)2.57042544
76Renal cortical cysts (HP:0000803)2.56202839
77Thyroiditis (HP:0100646)2.54798308
78Lipid accumulation in hepatocytes (HP:0006561)2.53329471
79Renal Fanconi syndrome (HP:0001994)2.51153826
80Myocardial infarction (HP:0001658)2.50522493
81Nausea (HP:0002018)2.45482628
82Alkalosis (HP:0001948)2.42989096
83Glycosuria (HP:0003076)2.42951481
84Abnormality of urine glucose concentration (HP:0011016)2.42951481
85Vomiting (HP:0002013)2.42578842
86Malnutrition (HP:0004395)2.40559694
87Sclerocornea (HP:0000647)2.37987558
88Hypoproteinemia (HP:0003075)2.37917599
89Methylmalonic aciduria (HP:0012120)2.37025193
90Optic disc pallor (HP:0000543)2.36181417
91Glomerulonephritis (HP:0000099)2.33846185
92Hydroxyprolinuria (HP:0003080)2.33507230
93Abnormality of proline metabolism (HP:0010907)2.33507230
94Abolished electroretinogram (ERG) (HP:0000550)2.32549654
95Congenital, generalized hypertrichosis (HP:0004540)2.31677602
96Hypoplasia of the fovea (HP:0007750)2.30311977
97Aplasia/Hypoplasia of the fovea (HP:0008060)2.30311977
98Attenuation of retinal blood vessels (HP:0007843)2.29678209
99Cardiovascular calcification (HP:0011915)2.29151176
100Spontaneous abortion (HP:0005268)2.28334232
101Abnormality of the lumbar spine (HP:0100712)2.27996745
102Hyperuricemia (HP:0002149)2.26925724
103Increased purine levels (HP:0004368)2.26925724
104Increased serum lactate (HP:0002151)2.25158744
105Tubular atrophy (HP:0000092)2.25059318
106Congenital primary aphakia (HP:0007707)2.24011326
107Cystic liver disease (HP:0006706)2.23256603
108Spastic diplegia (HP:0001264)2.22215946
109Pancreatitis (HP:0001733)2.22133403
110Amyloidosis (HP:0011034)2.21598110
111Anencephaly (HP:0002323)2.20244447
112Gait imbalance (HP:0002141)2.20192059
113Aplasia/Hypoplasia of the tibia (HP:0005772)2.16660261
114Protuberant abdomen (HP:0001538)2.16314532
115Decreased central vision (HP:0007663)2.15940277
116Irritability (HP:0000737)2.15932941
117Male pseudohermaphroditism (HP:0000037)2.14959242
118Acute encephalopathy (HP:0006846)2.13807589
119Nephrogenic diabetes insipidus (HP:0009806)2.13003351
120Polydipsia (HP:0001959)2.11602501
121Abnormal drinking behavior (HP:0030082)2.11602501
122Lactic acidosis (HP:0003128)2.10884869
123Hypoglycemic seizures (HP:0002173)2.09031102
124Vacuolated lymphocytes (HP:0001922)2.08858394
125Skin nodule (HP:0200036)2.08657941
126Abnormality of the fovea (HP:0000493)2.08633705
127Opisthotonus (HP:0002179)2.06208703
128Short tibia (HP:0005736)2.05096157
129Respiratory failure (HP:0002878)2.04210382
130Mucopolysacchariduria (HP:0008155)2.03639708
131Urinary glycosaminoglycan excretion (HP:0003541)2.03639708
132Congenital hepatic fibrosis (HP:0002612)2.03543177
133Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03519059
134Abnormality of macular pigmentation (HP:0008002)2.01750197
135Postaxial foot polydactyly (HP:0001830)2.01288556
136Hemorrhage of the eye (HP:0011885)2.01262743
137Furrowed tongue (HP:0000221)2.00679414
138Type II lissencephaly (HP:0007260)2.00155087
139Beaking of vertebral bodies (HP:0004568)1.98923956
140Intestinal atresia (HP:0011100)1.98419921
141Hyperventilation (HP:0002883)1.98347165
142Pendular nystagmus (HP:0012043)1.98211571
143Bile duct proliferation (HP:0001408)1.97759025
144Abnormal biliary tract physiology (HP:0012439)1.97759025
145Neonatal onset (HP:0003623)1.97393804
146Abnormal enzyme/coenzyme activity (HP:0012379)1.97169157
147Esophageal varix (HP:0002040)1.96613039
148Exertional dyspnea (HP:0002875)1.96385271
149Abnormal cartilage morphology (HP:0002763)1.96036019
150Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95282775
151Gingival bleeding (HP:0000225)1.95213342
152Genital tract atresia (HP:0001827)1.93532750
153Late onset (HP:0003584)1.93523063
154Abnormality of iron homeostasis (HP:0011031)1.92576284
155Hepatic necrosis (HP:0002605)1.91182472
156Abnormality of transition element cation homeostasis (HP:0011030)1.90630176
157Increased corneal curvature (HP:0100692)1.90284571
158Keratoconus (HP:0000563)1.90284571
159Chronic hepatic failure (HP:0100626)1.90274691
160Abnormal gallbladder morphology (HP:0012437)1.88825646
161Dysostosis multiplex (HP:0000943)1.88454517
162Mitral stenosis (HP:0001718)1.86856733
163J-shaped sella turcica (HP:0002680)1.86674793
164Pathologic fracture (HP:0002756)1.86298998
165Acanthocytosis (HP:0001927)1.85803963
166Menorrhagia (HP:0000132)1.85803330
167Abnormality of renal resorption (HP:0011038)1.85677335
168Thoracic kyphosis (HP:0002942)1.85652792
169Brushfield spots (HP:0001088)1.84947675
170Albinism (HP:0001022)1.83370223
171Type I transferrin isoform profile (HP:0003642)1.80637180
172Disproportionate short-trunk short stature (HP:0003521)1.79753319
173Polyuria (HP:0000103)1.78819387
174Postaxial hand polydactyly (HP:0001162)1.78199067
175Vaginal atresia (HP:0000148)1.77660530
176Colon cancer (HP:0003003)1.76606388
177Aplasia/Hypoplasia of the uvula (HP:0010293)1.75862331
178Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73515272
179Abnormality of alanine metabolism (HP:0010916)1.73515272
180Hyperalaninemia (HP:0003348)1.73515272
181Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.73236120
182Gaze-evoked nystagmus (HP:0000640)1.69204685
183Abnormality of vitamin B metabolism (HP:0004340)1.69172910
184Abnormality of B cell number (HP:0010975)1.68843112
185Optic nerve hypoplasia (HP:0000609)1.68661420
186Aplasia/hypoplasia of the uterus (HP:0008684)1.68178834
187Absent thumb (HP:0009777)1.68152216
188Preaxial hand polydactyly (HP:0001177)1.67387500
189Severe combined immunodeficiency (HP:0004430)1.67304829
190Type 2 muscle fiber atrophy (HP:0003554)1.66616038
191Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65716601
192Abnormal glycosylation (HP:0012345)1.65250264

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.17168865
2ERN13.78527703
3NME23.44111966
4NUAK13.30902606
5TRIM283.30033290
6BMPR1B3.20029825
7FGFR42.98027865
8MAP4K22.95479659
9ADRBK22.47399845
10ACVR1B2.45288065
11MAP3K142.43990630
12IRAK32.23462541
13MST1R2.21349801
14INSRR2.20038127
15SIK12.19671210
16TYK22.14973868
17PBK2.14957216
18FLT32.09206356
19TBK12.08635261
20TAOK32.05165080
21WNK42.01815289
22VRK21.96538025
23ERBB31.94680102
24ZAK1.84845302
25ABL21.79174986
26PLK21.76221303
27ERBB41.67215336
28MAP4K11.60580072
29MKNK21.58973469
30WNK31.57731138
31BLK1.53045241
32IRAK41.48051349
33PIK3CG1.47933262
34MAPK111.41897289
35MAPK131.41088071
36KDR1.40555036
37MET1.39751776
38PIM21.39151770
39TLK11.37727239
40IKBKB1.37335773
41BCR1.37281426
42VRK11.36542324
43OXSR11.36160267
44IKBKE1.32647150
45CASK1.32067241
46EIF2AK11.31742722
47MAP3K121.26846107
48DAPK21.24096714
49NEK91.23873472
50TNIK1.23419506
51TXK1.11989885
52CSNK1G11.11397677
53JAK31.11198791
54EPHB11.10341776
55MUSK1.09251881
56ZAP701.09154592
57BUB11.08931922
58JAK21.08639692
59PLK31.08068117
60FRK1.06591652
61CSNK1G31.05911014
62PAK31.05373436
63CSNK1G21.03529276
64MYLK1.03242665
65MAP3K31.02388164
66TGFBR11.02349303
67TGFBR20.98859789
68PTK60.97796465
69PRKCE0.96757686
70TIE10.96697256
71CSK0.95975809
72JAK10.94083048
73STK160.91894424
74MKNK10.88607420
75CSNK1A1L0.87906488
76EPHB20.86991641
77KIT0.86341671
78TEC0.85476037
79MAPK150.85385256
80PLK40.83048928
81SIK30.83006698
82FGFR20.82085779
83BTK0.81116947
84EIF2AK30.78913191
85GSK3A0.78823368
86TAF10.78401913
87NTRK10.78071224
88PHKG10.77939758
89PHKG20.77939758
90ADRBK10.77573068
91CSF1R0.77426282
92GRK70.77342770
93DYRK1B0.75661270
94PKN20.74834390
95WEE10.73524404
96LRRK20.73307503
97STK240.72995343
98MAP2K20.71916578
99CHUK0.71211690
100TRIB30.70388355
101BRSK20.69207864
102PRKCI0.68676840
103MAP2K30.68648939
104FER0.66113036
105GRK60.65977351
106PRKAA20.65887387
107MAP3K40.65667684
108PRKCD0.65152554
109STK38L0.63974379
110MAP3K110.63784035
111DAPK30.63657313
112EPHA40.63413827
113DYRK20.61469002
114STK30.61318232
115PRKCQ0.61246984
116PIK3CA0.60866769
117EPHA30.59588108
118MAPK40.59519919
119MAPKAPK50.59332961
120PRKCG0.59004946
121CDK60.58218232
122GRK50.57276057
123LYN0.54442682
124PTK2B0.54124218
125PIM10.53997666
126NLK0.52701368
127NEK10.50620667
128SYK0.49985608
129IGF1R0.48553099
130AKT30.48158036
131CDK80.47983761
132LIMK10.47634435
133IRAK10.47434004
134PKN10.47234629
135PRKCZ0.45005132
136PRKACG0.44266569
137CCNB10.43733607
138PDK20.42668796
139CAMK2A0.42604636
140MAPKAPK30.41216376
141ROCK10.41064049
142ILK0.40112846
143PINK10.39817366
144EIF2AK20.39485853
145TRPM70.38698990
146LCK0.38264300
147CAMKK20.37623509
148GRK10.37497065
149MINK10.37428923
150DAPK10.37273091
151PLK10.37221560
152ERBB20.37159725
153ABL10.36940905
154PNCK0.36458992
155MAP2K70.35991366
156ITK0.35861787
157EGFR0.35303887
158CSNK1A10.35201348
159STK390.34977805
160BMPR20.34712865
161RPS6KA60.34029677
162NTRK30.33938735
163PRKACA0.33831189
164MST40.33500005
165MAP2K10.33483226
166ARAF0.31357871
167MARK30.30332917
168CAMK2G0.29675915
169CAMK1D0.29525543
170PTK20.27772556
171RPS6KA40.27579413
172PRKG20.27535430

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.98068010
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37967756
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.25515291
4Arginine biosynthesis_Homo sapiens_hsa002202.67585531
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60204961
6Tryptophan metabolism_Homo sapiens_hsa003802.56585918
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.55542030
8Nitrogen metabolism_Homo sapiens_hsa009102.55391290
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50912954
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50167127
11Complement and coagulation cascades_Homo sapiens_hsa046102.41901512
12Fatty acid degradation_Homo sapiens_hsa000712.35824677
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.31544854
14Peroxisome_Homo sapiens_hsa041462.28863117
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.23747200
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12107108
17Propanoate metabolism_Homo sapiens_hsa006402.03477662
18Butanoate metabolism_Homo sapiens_hsa006501.98501036
19Basal transcription factors_Homo sapiens_hsa030221.96535660
20Phototransduction_Homo sapiens_hsa047441.93550126
21Homologous recombination_Homo sapiens_hsa034401.92897139
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91356831
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87473660
24Chemical carcinogenesis_Homo sapiens_hsa052041.86700699
25RNA polymerase_Homo sapiens_hsa030201.82543016
26Histidine metabolism_Homo sapiens_hsa003401.82457734
27Staphylococcus aureus infection_Homo sapiens_hsa051501.79342493
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.78209847
29Fanconi anemia pathway_Homo sapiens_hsa034601.77788579
30Huntingtons disease_Homo sapiens_hsa050161.75085004
31PPAR signaling pathway_Homo sapiens_hsa033201.74431551
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.73857858
33Sulfur metabolism_Homo sapiens_hsa009201.66427535
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64572214
35beta-Alanine metabolism_Homo sapiens_hsa004101.63427032
36Caffeine metabolism_Homo sapiens_hsa002321.61989600
37Fatty acid metabolism_Homo sapiens_hsa012121.61418796
38Phenylalanine metabolism_Homo sapiens_hsa003601.59606822
39Retinol metabolism_Homo sapiens_hsa008301.56262862
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55141290
41RNA degradation_Homo sapiens_hsa030181.53157983
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52670936
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51551188
44Folate biosynthesis_Homo sapiens_hsa007901.49959707
45Selenocompound metabolism_Homo sapiens_hsa004501.48500490
46Pyruvate metabolism_Homo sapiens_hsa006201.39848645
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.36897161
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36052005
49Fatty acid elongation_Homo sapiens_hsa000621.34344665
50Tyrosine metabolism_Homo sapiens_hsa003501.34263988
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33333690
52Asthma_Homo sapiens_hsa053101.28052218
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28014634
54Steroid biosynthesis_Homo sapiens_hsa001001.26789654
55Starch and sucrose metabolism_Homo sapiens_hsa005001.26668145
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.25972442
57Cardiac muscle contraction_Homo sapiens_hsa042601.24663754
58Ether lipid metabolism_Homo sapiens_hsa005651.22666047
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21902617
60Carbon metabolism_Homo sapiens_hsa012001.19548962
61Biosynthesis of amino acids_Homo sapiens_hsa012301.17127620
62Vitamin digestion and absorption_Homo sapiens_hsa049771.16715840
63Bile secretion_Homo sapiens_hsa049761.16691419
64Fat digestion and absorption_Homo sapiens_hsa049751.16068341
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12006492
66Non-homologous end-joining_Homo sapiens_hsa034501.10525128
67Collecting duct acid secretion_Homo sapiens_hsa049661.09566078
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08781954
69SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07798897
70Mismatch repair_Homo sapiens_hsa034301.07642568
71Nucleotide excision repair_Homo sapiens_hsa034201.06251390
72Glutathione metabolism_Homo sapiens_hsa004801.04784777
73Maturity onset diabetes of the young_Homo sapiens_hsa049501.04589575
74Arginine and proline metabolism_Homo sapiens_hsa003301.04063625
75Sulfur relay system_Homo sapiens_hsa041221.01166936
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99896587
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99770654
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97889660
79ABC transporters_Homo sapiens_hsa020100.96781581
80Type I diabetes mellitus_Homo sapiens_hsa049400.93196483
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90290317
82Purine metabolism_Homo sapiens_hsa002300.83188692
83Primary immunodeficiency_Homo sapiens_hsa053400.82989836
84Allograft rejection_Homo sapiens_hsa053300.82667252
85One carbon pool by folate_Homo sapiens_hsa006700.78337196
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77614671
87Autoimmune thyroid disease_Homo sapiens_hsa053200.76121673
88Pentose phosphate pathway_Homo sapiens_hsa000300.71577158
89Pyrimidine metabolism_Homo sapiens_hsa002400.71469338
90Mineral absorption_Homo sapiens_hsa049780.70582747
91Glycerolipid metabolism_Homo sapiens_hsa005610.69261458
92Nicotine addiction_Homo sapiens_hsa050330.69062605
93Vitamin B6 metabolism_Homo sapiens_hsa007500.65093641
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62652695
95Olfactory transduction_Homo sapiens_hsa047400.61825409
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60701323
97Metabolic pathways_Homo sapiens_hsa011000.58526824
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51820721
99Lysine degradation_Homo sapiens_hsa003100.51533083
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49402739
101Circadian rhythm_Homo sapiens_hsa047100.47681721
102Oxidative phosphorylation_Homo sapiens_hsa001900.43700358
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43541901
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42817441
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42344823
106Hedgehog signaling pathway_Homo sapiens_hsa043400.41894778
107Taste transduction_Homo sapiens_hsa047420.40128579
108Linoleic acid metabolism_Homo sapiens_hsa005910.39288839
109Insulin secretion_Homo sapiens_hsa049110.37141966
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36200322
111Morphine addiction_Homo sapiens_hsa050320.35326845
112RNA transport_Homo sapiens_hsa030130.35053715
113p53 signaling pathway_Homo sapiens_hsa041150.32833107
114Ovarian steroidogenesis_Homo sapiens_hsa049130.32460291
115Fructose and mannose metabolism_Homo sapiens_hsa000510.31001753
116Lysosome_Homo sapiens_hsa041420.25757639
117Arachidonic acid metabolism_Homo sapiens_hsa005900.25394603
118Galactose metabolism_Homo sapiens_hsa000520.24902127
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.24109961
120Prion diseases_Homo sapiens_hsa050200.23712371
121Protein export_Homo sapiens_hsa030600.23395204
122Other glycan degradation_Homo sapiens_hsa005110.21836553
123Parkinsons disease_Homo sapiens_hsa050120.18923476
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18473156
125Fatty acid biosynthesis_Homo sapiens_hsa000610.15562845
126Legionellosis_Homo sapiens_hsa051340.13108048
127Insulin resistance_Homo sapiens_hsa049310.11862457
128Proteasome_Homo sapiens_hsa030500.11492672
129Renin-angiotensin system_Homo sapiens_hsa046140.10109705
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.09128938
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.08362780
132Pertussis_Homo sapiens_hsa051330.08204767
133Graft-versus-host disease_Homo sapiens_hsa053320.06156241
134Alzheimers disease_Homo sapiens_hsa050100.04287470
135NF-kappa B signaling pathway_Homo sapiens_hsa040640.03257982
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.02982136
137African trypanosomiasis_Homo sapiens_hsa051430.02834172
138Ribosome_Homo sapiens_hsa030100.01144368
139Malaria_Homo sapiens_hsa051440.00583062
140Rheumatoid arthritis_Homo sapiens_hsa05323-0.0244757
141Regulation of autophagy_Homo sapiens_hsa04140-0.0159109
142Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0076178

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