IAPP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)7.29773115
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.23273204
3* endocrine pancreas development (GO:0031018)7.04563829
4signal peptide processing (GO:0006465)7.03291355
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.91831346
6COPII vesicle coating (GO:0048208)6.83124598
7peptide hormone processing (GO:0016486)6.64729709
8negative regulation of protein oligomerization (GO:0032460)6.44585660
9positive regulation of respiratory burst (GO:0060267)6.34849182
10negative regulation of acute inflammatory response (GO:0002674)6.32797059
11regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022356.13949494
12glandular epithelial cell differentiation (GO:0002067)6.09095283
13protein retention in ER lumen (GO:0006621)6.08560617
14regulation of type B pancreatic cell apoptotic process (GO:2000674)6.05440461
15sequestering of metal ion (GO:0051238)5.82855109
16activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.64694968
17ER overload response (GO:0006983)5.54333622
18type B pancreatic cell development (GO:0003323)5.52748054
19cellular ketone body metabolic process (GO:0046950)5.52088297
20negative regulation of gluconeogenesis (GO:0045721)5.41282589
21insulin secretion (GO:0030073)5.41073162
22positive regulation of nuclease activity (GO:0032075)5.38733253
23inositol phosphate catabolic process (GO:0071545)5.31822042
24glandular epithelial cell development (GO:0002068)5.25234531
25positive regulation of insulin secretion (GO:0032024)5.16972389
26vesicle coating (GO:0006901)5.09976775
27exocrine pancreas development (GO:0031017)5.09858387
28negative regulation of glycogen metabolic process (GO:0070874)5.05127305
29fatty acid homeostasis (GO:0055089)5.00882582
30regulation of nuclease activity (GO:0032069)4.92363817
31positive regulation of protein autophosphorylation (GO:0031954)4.90946000
32ketone body metabolic process (GO:1902224)4.88696486
33regulation of insulin secretion (GO:0050796)4.79066050
34negative regulation of hormone biosynthetic process (GO:0032353)4.76559801
35endoplasmic reticulum unfolded protein response (GO:0030968)4.75678511
36phosphorylated carbohydrate dephosphorylation (GO:0046838)4.69812882
37inositol phosphate dephosphorylation (GO:0046855)4.69812882
38cellular response to unfolded protein (GO:0034620)4.69274751
39cellular response to topologically incorrect protein (GO:0035967)4.58039935
40ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.56446464
41fructose metabolic process (GO:0006000)4.52039744
42ER-nucleus signaling pathway (GO:0006984)4.47412551
43negative regulation of Ras GTPase activity (GO:0034261)4.46081056
44detection of calcium ion (GO:0005513)4.40761438
45regulation of peptide hormone secretion (GO:0090276)4.37865571
46intra-Golgi vesicle-mediated transport (GO:0006891)4.35764750
47regulation of peptide secretion (GO:0002791)4.29543666
48positive regulation of glycogen biosynthetic process (GO:0045725)4.29310768
49positive regulation of insulin receptor signaling pathway (GO:0046628)4.19894273
50columnar/cuboidal epithelial cell development (GO:0002066)4.18693390
51positive regulation of peptide hormone secretion (GO:0090277)4.16658623
52negative regulation of glycoprotein biosynthetic process (GO:0010561)4.10797630
53negative regulation of hormone metabolic process (GO:0032351)4.10581286
54positive regulation of peptide secretion (GO:0002793)4.01670998
55polyol catabolic process (GO:0046174)3.96452689
56negative regulation of insulin secretion (GO:0046676)3.95660850
57peptide hormone secretion (GO:0030072)3.93459666
58ER to Golgi vesicle-mediated transport (GO:0006888)3.93393796
59protein N-linked glycosylation via asparagine (GO:0018279)3.91599986
60response to endoplasmic reticulum stress (GO:0034976)3.90775571
61regulation of hexokinase activity (GO:1903299)3.89395155
62regulation of glucokinase activity (GO:0033131)3.89395155
63peptidyl-asparagine modification (GO:0018196)3.89146330
64nitric oxide mediated signal transduction (GO:0007263)3.86194307
65positive regulation of vasodilation (GO:0045909)3.86188496
66negative regulation of norepinephrine secretion (GO:0010700)3.84573900
67peptide secretion (GO:0002790)3.84507585
68toxin metabolic process (GO:0009404)3.84005329
69regulation of hormone secretion (GO:0046883)3.80666390
70positive regulation of growth hormone secretion (GO:0060124)3.78499322
71positive regulation of glycogen metabolic process (GO:0070875)3.75487467
72regulation of feeding behavior (GO:0060259)3.70993526
73protein localization to Golgi apparatus (GO:0034067)3.70552179
74negative regulation of catecholamine secretion (GO:0033604)3.67475688
75response to unfolded protein (GO:0006986)3.65324984
76epithelial cell fate commitment (GO:0072148)3.62335247
77astrocyte differentiation (GO:0048708)3.60919218
78regulation of glucocorticoid secretion (GO:2000849)3.60302359
79macroautophagy (GO:0016236)3.60231173
80protein N-linked glycosylation (GO:0006487)3.58883512
81cellular zinc ion homeostasis (GO:0006882)3.56574363
82response to topologically incorrect protein (GO:0035966)3.56533035
83regulation of peptide transport (GO:0090087)3.53338760
84histamine secretion (GO:0001821)3.50664830
85cellular response to vitamin D (GO:0071305)3.50219311
86zinc ion homeostasis (GO:0055069)3.49209095
87regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.44832900
88negative regulation of peptide hormone secretion (GO:0090278)3.44514907
89nucleoside diphosphate catabolic process (GO:0009134)3.40465210
90Golgi organization (GO:0007030)3.37578288
91artery smooth muscle contraction (GO:0014824)3.35599533
92regulation of glucocorticoid metabolic process (GO:0031943)3.34380821
93negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.34051445
94interleukin-1-mediated signaling pathway (GO:0070498)3.33399992
95response to hexose (GO:0009746)3.33399844
96positive regulation of hormone secretion (GO:0046887)3.33171499
97regulation of Golgi to plasma membrane protein transport (GO:0042996)3.32044344
98negative regulation of peptide secretion (GO:0002792)3.32003079
99positive regulation of nitric-oxide synthase activity (GO:0051000)3.31011912
100regulation of protein glycosylation (GO:0060049)3.28785001
101response to glucose (GO:0009749)3.27951976
102regulation of glycolytic process (GO:0006110)3.26497609
103positive regulation of actin filament depolymerization (GO:0030836)3.23554845
104negative regulation of neurological system process (GO:0031645)3.23332764
105kidney morphogenesis (GO:0060993)3.19683982
106purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.19318894
1073-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.19318894
108GDP-mannose metabolic process (GO:0019673)3.18115791
109response to monosaccharide (GO:0034284)3.15966078
110hormone secretion (GO:0046879)3.12014130
111L-alpha-amino acid transmembrane transport (GO:1902475)3.11454203
112zinc ion transmembrane transport (GO:0071577)3.11409177
113negative regulation of glial cell proliferation (GO:0060253)3.11169333
114Golgi vesicle transport (GO:0048193)3.10712335
115regulation of respiratory burst (GO:0060263)3.09944944
116positive regulation of glycolytic process (GO:0045821)3.09121327
117regulation of steroid hormone biosynthetic process (GO:0090030)3.08933381
118peptide transport (GO:0015833)3.06895367
119negative regulation of glycoprotein metabolic process (GO:1903019)3.06266271
120acrosome reaction (GO:0007340)3.05617306
121intestinal epithelial cell development (GO:0060576)3.05302775
122hormone transport (GO:0009914)3.04764544
123cerebellar Purkinje cell layer development (GO:0021680)3.03510535
124dendritic spine morphogenesis (GO:0060997)3.03023147
125glucose homeostasis (GO:0042593)3.02656205
126carbohydrate homeostasis (GO:0033500)3.02656205
127regulation of oxidative phosphorylation (GO:0002082)3.02246512
128inner ear receptor cell development (GO:0060119)3.01083234
129positive regulation of glycoprotein biosynthetic process (GO:0010560)3.00626656
130regulation of protein autophosphorylation (GO:0031952)2.98266678
131lactate metabolic process (GO:0006089)2.97997589
132zinc ion transport (GO:0006829)2.95889291
133cellular response to glucagon stimulus (GO:0071377)2.91800703
134protein targeting to Golgi (GO:0000042)2.90460258
135positive regulation of cellular carbohydrate metabolic process (GO:0010676)2.89313363
136negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.89101425
137signal transduction involved in regulation of gene expression (GO:0023019)2.88924552
138regulation of corticosteroid hormone secretion (GO:2000846)2.87891586
139positive regulation of carbohydrate metabolic process (GO:0045913)2.86258772
140response to hepatocyte growth factor (GO:0035728)2.85697382
141cellular response to hepatocyte growth factor stimulus (GO:0035729)2.85697382
142water-soluble vitamin biosynthetic process (GO:0042364)2.84670301
143protein autoprocessing (GO:0016540)2.82951628
144regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.82692655
145energy homeostasis (GO:0097009)2.82485140
146prenylation (GO:0097354)2.81232759
147protein prenylation (GO:0018342)2.81232759
148tonic smooth muscle contraction (GO:0014820)2.79971093
149keratinocyte development (GO:0003334)2.79942789
150righting reflex (GO:0060013)2.79505796
151positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.77798755
152histamine transport (GO:0051608)2.75697257
153regulation of growth hormone secretion (GO:0060123)2.74768192
154establishment of protein localization to Golgi (GO:0072600)2.71539887
155prostate gland growth (GO:0060736)2.71075807
156xenobiotic catabolic process (GO:0042178)2.69838871
157regulation of cellular carbohydrate catabolic process (GO:0043471)2.69609932
158regulation of carbohydrate catabolic process (GO:0043470)2.69609932
159positive regulation of response to nutrient levels (GO:0032109)2.69593783
160positive regulation of response to extracellular stimulus (GO:0032106)2.69593783
161COPI coating of Golgi vesicle (GO:0048205)11.4011328
162Golgi transport vesicle coating (GO:0048200)11.4011328

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.64162907
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.96833848
3GATA1_22025678_ChIP-Seq_K562_Human4.24222780
4PDX1_19855005_ChIP-ChIP_MIN6_Mouse4.20307524
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.70582776
6PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.31770911
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30844000
8GBX2_23144817_ChIP-Seq_PC3_Human2.12036350
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07137450
10CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.88262017
11P300_19829295_ChIP-Seq_ESCs_Human1.85407360
12FLI1_27457419_Chip-Seq_LIVER_Mouse1.84693883
13FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.76503129
14TFEB_21752829_ChIP-Seq_HELA_Human1.75481835
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75056512
16SMAD4_21799915_ChIP-Seq_A2780_Human1.73418844
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71642145
18* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.71107681
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70886388
20AR_25329375_ChIP-Seq_VCAP_Human1.70725875
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70515481
22NR3C1_23031785_ChIP-Seq_PC12_Mouse1.70123147
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69741019
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69513371
25ER_23166858_ChIP-Seq_MCF-7_Human1.67180316
26REST_19997604_ChIP-ChIP_NEURONS_Mouse1.64851516
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62343402
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.61347357
29REST_21632747_ChIP-Seq_MESCs_Mouse1.61321852
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61271558
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58058415
32IGF1R_20145208_ChIP-Seq_DFB_Human1.56253184
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56101695
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55723309
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54339060
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52725611
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.51275354
38OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.49705769
39SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.48742757
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48010431
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.45952592
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45670199
43AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.45195407
44FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.44492490
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.43992918
46FOXA1_25552417_ChIP-Seq_VCAP_Human1.41812127
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40950530
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40304381
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36282435
50P53_22387025_ChIP-Seq_ESCs_Mouse1.35955298
51CMYC_18555785_Chip-Seq_ESCs_Mouse1.33878706
52HTT_18923047_ChIP-ChIP_STHdh_Human1.33259951
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33117357
54ZNF274_21170338_ChIP-Seq_K562_Hela1.32208205
55CDX2_22108803_ChIP-Seq_LS180_Human1.29901828
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.29666598
57ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29554428
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.29381236
59FUS_26573619_Chip-Seq_HEK293_Human1.28414687
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26734130
61FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.26507638
62CRX_20693478_ChIP-Seq_RETINA_Mouse1.25694419
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.25694394
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25284739
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24894737
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24875397
67CBP_20019798_ChIP-Seq_JUKART_Human1.24875397
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24402486
69NANOG_19829295_ChIP-Seq_ESCs_Human1.24102909
70SOX2_19829295_ChIP-Seq_ESCs_Human1.24102909
71CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22890609
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22080112
73EWS_26573619_Chip-Seq_HEK293_Human1.21945165
74ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19474776
75STAT3_23295773_ChIP-Seq_U87_Human1.19295180
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.18588907
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18462891
78P300_18555785_Chip-Seq_ESCs_Mouse1.18403495
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17171189
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16259739
81TCF4_22108803_ChIP-Seq_LS180_Human1.16182556
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15732797
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15569872
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14654748
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14565904
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.14306034
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14256090
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13967550
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13733439
90ERG_20517297_ChIP-Seq_VCAP_Human1.12122822
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12017927
92CTCF_18555785_Chip-Seq_ESCs_Mouse1.11516836
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11173704
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10941056
95CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.10912868
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09673920
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.08464704
98TP53_22573176_ChIP-Seq_HFKS_Human1.08439884
99SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08320613
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07524564
101PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07029253
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.06754548
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.06223450
104PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05895236
105EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05713399
106SOX2_18555785_Chip-Seq_ESCs_Mouse1.05693156
107VDR_22108803_ChIP-Seq_LS180_Human1.05276029
108LXR_22158963_ChIP-Seq_LIVER_Mouse1.05111829
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.04619956
110RUNX2_22187159_ChIP-Seq_PCA_Human1.02970941
111ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02608239
112SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02355206
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02219036
114FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02002965
115FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01439660
116VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01086649
117KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00841493
118* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99952424
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99943408
120HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99922891
121SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99705761
122* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99588067
123SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98399847
124PU1_27457419_Chip-Seq_LIVER_Mouse0.98083379
125CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97185224
126ZFX_18555785_Chip-Seq_ESCs_Mouse0.96280726
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94812260
128GATA3_27048872_Chip-Seq_THYMUS_Human0.93620471
129GATA1_19941826_ChIP-Seq_K562_Human0.93453121
130GATA3_24758297_ChIP-Seq_MCF-7_Human0.92852663
131ESR1_21235772_ChIP-Seq_MCF-7_Human0.92476306
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92413706
133GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91662204
134FLI1_21867929_ChIP-Seq_TH2_Mouse0.90442057
135CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90428752
136FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89973506
137ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89828248
138NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89313265
139YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86759487
140RXR_22158963_ChIP-Seq_LIVER_Mouse0.86393972
141CHD1_26751641_Chip-Seq_LNCaP_Human0.86349477
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85105553
143CLOCK_20551151_ChIP-Seq_293T_Human0.84787282
144SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83993577
145EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83769957
146STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83063388
147SOX2_20726797_ChIP-Seq_SW620_Human0.82136662
148MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82073542
149ZFX_18555785_ChIP-Seq_MESCs_Mouse0.82041359
150JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.81854090
151HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.80843337
152AR_20517297_ChIP-Seq_VCAP_Human0.79704393
153SMAD3_21741376_ChIP-Seq_ESCs_Human0.78941442
154EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78561538
155FOXA1_25329375_ChIP-Seq_VCAP_Human0.78538258
156FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78538258
157STAT3_18555785_Chip-Seq_ESCs_Mouse0.78503100
158PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78243750
159BCAT_22108803_ChIP-Seq_LS180_Human0.78195541
160NANOG_18555785_Chip-Seq_ESCs_Mouse0.77768268
161CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.77136334
162NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.76757195
163ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75769193
164GF1B_26923725_Chip-Seq_HPCs_Mouse0.75412652
165TCF4_23295773_ChIP-Seq_U87_Human0.75304633
166FOXA1_21572438_ChIP-Seq_LNCaP_Human0.75255431
167MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.75215232
168OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75149286
169FOXA2_19822575_ChIP-Seq_HepG2_Human0.75065128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog5.84692839
2MP0003283_abnormal_digestive_organ4.74617522
3MP0004043_abnormal_pH_regulation4.54829397
4MP0002693_abnormal_pancreas_physiology4.47123901
5MP0009780_abnormal_chondrocyte_physiolo4.24813349
6MP0002909_abnormal_adrenal_gland4.13469241
7MP0000013_abnormal_adipose_tissue4.11404760
8MP0010386_abnormal_urinary_bladder4.04357515
9MP0010234_abnormal_vibrissa_follicle3.97981777
10MP0001944_abnormal_pancreas_morphology3.96504038
11MP0005379_endocrine/exocrine_gland_phen3.51805073
12MP0003195_calcinosis3.49179857
13MP0003123_paternal_imprinting3.43727322
14MP0003183_abnormal_peptide_metabolism3.41523882
15MP0000678_abnormal_parathyroid_gland3.22153803
16MP0002837_dystrophic_cardiac_calcinosis2.96068607
17MP0005220_abnormal_exocrine_pancreas2.93647290
18MP0008877_abnormal_DNA_methylation2.55946242
19MP0002102_abnormal_ear_morphology2.48780866
20MP0006072_abnormal_retinal_apoptosis2.48522328
21MP0000569_abnormal_digit_pigmentation2.43028539
22MP0002822_catalepsy2.42736256
23* MP0002078_abnormal_glucose_homeostasis2.35236325
24MP0003121_genomic_imprinting2.15003920
25MP0005646_abnormal_pituitary_gland2.12791526
26MP0001986_abnormal_taste_sensitivity2.10092601
27MP0000003_abnormal_adipose_tissue2.08565030
28MP0004264_abnormal_extraembryonic_tissu1.99787908
29MP0002638_abnormal_pupillary_reflex1.83927934
30MP0001984_abnormal_olfaction1.78587161
31MP0005645_abnormal_hypothalamus_physiol1.70175602
32MP0002277_abnormal_respiratory_mucosa1.68612006
33MP0002928_abnormal_bile_duct1.65950733
34MP0003172_abnormal_lysosome_physiology1.65130371
35MP0005367_renal/urinary_system_phenotyp1.64113809
36MP0000516_abnormal_urinary_system1.64113809
37MP0009046_muscle_twitch1.60007487
38MP0003300_gastrointestinal_ulcer1.55622167
39MP0003122_maternal_imprinting1.52287959
40MP0005075_abnormal_melanosome_morpholog1.50874691
41MP0002896_abnormal_bone_mineralization1.50305936
42MP0005058_abnormal_lysosome_morphology1.50254206
43MP0001765_abnormal_ion_homeostasis1.49992846
44MP0003868_abnormal_feces_composition1.47626436
45MP0008961_abnormal_basal_metabolism1.46392874
46MP0000462_abnormal_digestive_system1.45896144
47MP0002090_abnormal_vision1.43745892
48MP0005257_abnormal_intraocular_pressure1.42919498
49MP0002938_white_spotting1.41832566
50MP0000613_abnormal_salivary_gland1.40021043
51* MP0003953_abnormal_hormone_level1.39887615
52MP0002234_abnormal_pharynx_morphology1.38593857
53MP0009643_abnormal_urine_homeostasis1.33880241
54MP0010678_abnormal_skin_adnexa1.33063400
55MP0003633_abnormal_nervous_system1.31642499
56MP0002876_abnormal_thyroid_physiology1.31353897
57MP0005310_abnormal_salivary_gland1.29688605
58MP0000427_abnormal_hair_cycle1.26191621
59MP0002163_abnormal_gland_morphology1.25898089
60MP0003252_abnormal_bile_duct1.21657250
61MP0005535_abnormal_body_temperature1.18410952
62MP0002138_abnormal_hepatobiliary_system1.17884562
63MP0004885_abnormal_endolymph1.14390864
64MP0004270_analgesia1.12929449
65MP0003011_delayed_dark_adaptation1.11786379
66MP0000631_abnormal_neuroendocrine_gland1.11338365
67MP0001756_abnormal_urination1.11185953
68MP0005365_abnormal_bile_salt1.08651454
69MP0005551_abnormal_eye_electrophysiolog1.07268370
70MP0010329_abnormal_lipoprotein_level1.07020247
71MP0003890_abnormal_embryonic-extraembry1.05958122
72MP0001727_abnormal_embryo_implantation1.05616987
73MP0009745_abnormal_behavioral_response1.02153071
74MP0003959_abnormal_lean_body1.01917364
75MP0002254_reproductive_system_inflammat1.01634939
76MP0006054_spinal_hemorrhage1.01128198
77MP0002139_abnormal_hepatobiliary_system1.00282632
78MP0002064_seizures0.98664281
79MP0010352_gastrointestinal_tract_polyps0.98204641
80MP0005636_abnormal_mineral_homeostasis0.97341251
81MP0003119_abnormal_digestive_system0.97176183
82MP0002160_abnormal_reproductive_system0.95239805
83MP0002557_abnormal_social/conspecific_i0.95177487
84MP0004134_abnormal_chest_morphology0.92528919
85MP0001270_distended_abdomen0.92353091
86MP0004510_myositis0.92300047
87MP0009697_abnormal_copulation0.91741465
88MP0000538_abnormal_urinary_bladder0.91096619
89MP0005253_abnormal_eye_physiology0.89180130
90MP0005375_adipose_tissue_phenotype0.88344407
91MP0000681_abnormal_thyroid_gland0.88081986
92MP0005332_abnormal_amino_acid0.87290455
93MP0006036_abnormal_mitochondrial_physio0.87210509
94MP0003866_abnormal_defecation0.87029944
95MP0001502_abnormal_circadian_rhythm0.84836831
96MP0005448_abnormal_energy_balance0.83486948
97MP0001905_abnormal_dopamine_level0.83076873
98MP0004859_abnormal_synaptic_plasticity0.78124059
99MP0009672_abnormal_birth_weight0.77493673
100MP0000639_abnormal_adrenal_gland0.77457922
101MP0003943_abnormal_hepatobiliary_system0.76136824
102MP0001661_extended_life_span0.75488851
103MP0002572_abnormal_emotion/affect_behav0.74947737
104MP0001299_abnormal_eye_distance/0.74782412
105MP0004924_abnormal_behavior0.74368216
106MP0005386_behavior/neurological_phenoty0.74368216
107MP0000230_abnormal_systemic_arterial0.74271335
108MP0002272_abnormal_nervous_system0.74115133
109MP0005408_hypopigmentation0.73625473
110MP0001440_abnormal_grooming_behavior0.71104194
111MP0005334_abnormal_fat_pad0.69189086
112MP0003045_fibrosis0.68147230
113MP0001666_abnormal_nutrient_absorption0.67336621
114MP0003879_abnormal_hair_cell0.67057267
115MP0002295_abnormal_pulmonary_circulatio0.66189771
116MP0003806_abnormal_nucleotide_metabolis0.64830363
117MP0006292_abnormal_olfactory_placode0.64298823
118MP0002118_abnormal_lipid_homeostasis0.63866285
119MP0005266_abnormal_metabolism0.62395164
120MP0000647_abnormal_sebaceous_gland0.61914318
121MP0004142_abnormal_muscle_tone0.61656016
122MP0002166_altered_tumor_susceptibility0.60975847
123MP0005174_abnormal_tail_pigmentation0.60717485
124MP0009703_decreased_birth_body0.59812058
125MP0005452_abnormal_adipose_tissue0.59738130
126MP0001186_pigmentation_phenotype0.59555445
127MP0003631_nervous_system_phenotype0.59495700
128MP0005410_abnormal_fertilization0.58875754
129MP0002184_abnormal_innervation0.58654708
130MP0004145_abnormal_muscle_electrophysio0.57983451
131MP0003690_abnormal_glial_cell0.57349745
132MP0008872_abnormal_physiological_respon0.56967995
133MP0005187_abnormal_penis_morphology0.56183032
134MP0001919_abnormal_reproductive_system0.55280217
135* MP0009642_abnormal_blood_homeostasis0.55027577
136MP0002177_abnormal_outer_ear0.54312497
137MP0002069_abnormal_eating/drinking_beha0.52540625
138MP0005670_abnormal_white_adipose0.52077620
139MP0002970_abnormal_white_adipose0.48210590
140MP0002733_abnormal_thermal_nociception0.48197392
141MP0001664_abnormal_digestion0.47144790
142MP0002734_abnormal_mechanical_nocicepti0.46359956
143MP0002168_other_aberrant_phenotype0.46181625
144MP0005076_abnormal_cell_differentiation0.45418464
145* MP0003795_abnormal_bone_structure0.44014194
146MP0001764_abnormal_homeostasis0.43818470
147MP0001731_abnormal_postnatal_growth0.43739769
148MP0003787_abnormal_imprinting0.43514439
149MP0005389_reproductive_system_phenotype0.43170842
150MP0000163_abnormal_cartilage_morphology0.40830992
151MP0002229_neurodegeneration0.39818115
152MP0005085_abnormal_gallbladder_physiolo0.38868397
153MP0002751_abnormal_autonomic_nervous0.38473897
154MP0000609_abnormal_liver_physiology0.37723322

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)8.31599729
2Hypoglycemic seizures (HP:0002173)7.59621676
3Symptomatic seizures (HP:0011145)6.98952874
4Hypoglycemic coma (HP:0001325)6.58577030
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.34149291
6Hyperglycemia (HP:0003074)5.29352077
7Insulin-resistant diabetes mellitus (HP:0000831)5.27292948
8Abnormality of endocrine pancreas physiology (HP:0012093)4.91391796
9Abnormality of the pancreatic islet cells (HP:0006476)4.91391796
10Pancreatic islet-cell hyperplasia (HP:0004510)4.64464699
11Ketoacidosis (HP:0001993)4.56614523
12Decreased circulating renin level (HP:0003351)4.46460184
13Abnormality of calcium-phosphate metabolism (HP:0100530)4.28521303
14Large for gestational age (HP:0001520)4.25222151
15Late onset (HP:0003584)4.16211630
16Abnormal pancreas size (HP:0012094)4.12256375
17Urinary glycosaminoglycan excretion (HP:0003541)3.96548278
18Mucopolysacchariduria (HP:0008155)3.96548278
19Generalized aminoaciduria (HP:0002909)3.70043577
20Dysostosis multiplex (HP:0000943)3.64064935
21Abnormality of polysaccharide metabolism (HP:0011012)3.63371402
22Abnormality of glycosaminoglycan metabolism (HP:0004371)3.63371402
23Abnormality of mucopolysaccharide metabolism (HP:0011020)3.63371402
24Type I diabetes mellitus (HP:0100651)3.49841955
25Neoplasm of the adrenal cortex (HP:0100641)3.47108434
26Enlarged penis (HP:0000040)3.46899857
27Hypokalemia (HP:0002900)3.40095966
28Abnormality of the intrinsic pathway (HP:0010989)3.38321938
29Insulin resistance (HP:0000855)3.14585026
30Agitation (HP:0000713)3.14491556
31Osteomalacia (HP:0002749)3.12478670
32Hypomagnesemia (HP:0002917)3.04931823
33Tongue fasciculations (HP:0001308)2.94592714
34Abnormality of aromatic amino acid family metabolism (HP:0004338)2.94231366
35Conjugated hyperbilirubinemia (HP:0002908)2.87577756
36Prominent metopic ridge (HP:0005487)2.83304519
37Hyperactive renin-angiotensin system (HP:0000841)2.76313240
38Abnormality of renin-angiotensin system (HP:0000847)2.75912867
39Hypoplasia of the fovea (HP:0007750)2.75544103
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.75544103
41Abnormality of the fovea (HP:0000493)2.71247285
42Hyperparathyroidism (HP:0000843)2.69545817
43Hyperkalemia (HP:0002153)2.67979618
44Abnormality of potassium homeostasis (HP:0011042)2.67863320
45Conjunctival hamartoma (HP:0100780)2.67589610
46Unilateral renal agenesis (HP:0000122)2.62543572
47Retinal atrophy (HP:0001105)2.62093054
48Limb hypertonia (HP:0002509)2.61628254
49Hypothermia (HP:0002045)2.59202275
50Hamartoma of the eye (HP:0010568)2.54321552
51Downturned corners of mouth (HP:0002714)2.52817551
52Chronic bronchitis (HP:0004469)2.52356565
53Muscle fibrillation (HP:0010546)2.52209728
54Ketosis (HP:0001946)2.51903018
55Hypokinesia (HP:0002375)2.51380057
56Hyperthyroidism (HP:0000836)2.50985684
57Hepatic necrosis (HP:0002605)2.49124958
58Progressive neurologic deterioration (HP:0002344)2.46505115
59Metaphyseal dysplasia (HP:0100255)2.43868528
60EEG with generalized epileptiform discharges (HP:0011198)2.42481182
61Abnormal protein glycosylation (HP:0012346)2.40912308
62Abnormal glycosylation (HP:0012345)2.40912308
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.40912308
64Abnormal protein N-linked glycosylation (HP:0012347)2.40912308
65Hypsarrhythmia (HP:0002521)2.40152582
66Abnormality of the metopic suture (HP:0005556)2.39325601
67Thoracolumbar scoliosis (HP:0002944)2.38810183
68Dysautonomia (HP:0002459)2.38691041
69Neoplasm of the adrenal gland (HP:0100631)2.35000252
70Methylmalonic acidemia (HP:0002912)2.31288168
71Epileptiform EEG discharges (HP:0011182)2.30546389
72Increased circulating renin level (HP:0000848)2.30098763
73Abnormality of magnesium homeostasis (HP:0004921)2.28062963
74Testicular neoplasm (HP:0010788)2.27739849
75Muscular hypotonia of the trunk (HP:0008936)2.26756662
76Cortical visual impairment (HP:0100704)2.23373744
77Exocrine pancreatic insufficiency (HP:0001738)2.22703431
78Hematochezia (HP:0002573)2.18636091
79Pheochromocytoma (HP:0002666)2.17824366
80Abdominal distention (HP:0003270)2.16604122
81Hepatoblastoma (HP:0002884)2.15460121
82Stridor (HP:0010307)2.14928043
83Sensory axonal neuropathy (HP:0003390)2.14182733
84Progressive macrocephaly (HP:0004481)2.10042763
85Abnormal drinking behavior (HP:0030082)2.09173242
86Polydipsia (HP:0001959)2.09173242
87Acute hepatic failure (HP:0006554)2.07933099
88Congenital glaucoma (HP:0001087)2.06289771
89Intestinal atresia (HP:0011100)2.06025743
90Hypokalemic alkalosis (HP:0001949)2.03826124
91Hypobetalipoproteinemia (HP:0003563)2.03300927
92Papilledema (HP:0001085)2.03047271
93Type I transferrin isoform profile (HP:0003642)2.02121209
94Abnormality of methionine metabolism (HP:0010901)2.02019406
95Visual hallucinations (HP:0002367)1.99510442
96Vacuolated lymphocytes (HP:0001922)1.98587905
97Hemiparesis (HP:0001269)1.98514908
98Diminished movement (HP:0002374)1.95852279
99Menstrual irregularities (HP:0000858)1.95486163
100Epileptic encephalopathy (HP:0200134)1.95323857
101Thyroiditis (HP:0100646)1.95193240
102Villous atrophy (HP:0011473)1.94055759
103Abnormality of small intestinal villus morphology (HP:0011472)1.94055759
104Gout (HP:0001997)1.92975245
105Abnormality of the common coagulation pathway (HP:0010990)1.92882011
106Asymmetry of the thorax (HP:0001555)1.91180058
107Disproportionate short-trunk short stature (HP:0003521)1.91136042
108Restlessness (HP:0000711)1.90100855
109Cutaneous melanoma (HP:0012056)1.89879747
110Macroorchidism (HP:0000053)1.89250991
111Neuroendocrine neoplasm (HP:0100634)1.88823733
112Hypotension (HP:0002615)1.88658393
113Cystic liver disease (HP:0006706)1.88525643
114Irregular vertebral endplates (HP:0003301)1.87940708
115Hypercortisolism (HP:0001578)1.86718762
116Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.85691395
117Aqueductal stenosis (HP:0002410)1.85118045
118Abnormality of chloride homeostasis (HP:0011422)1.84845164
119Hypophosphatemia (HP:0002148)1.84820117
120Furrowed tongue (HP:0000221)1.84225481
121Hyperphosphatemia (HP:0002905)1.83945392
122Protuberant abdomen (HP:0001538)1.83914505
123Abnormal sex determination (HP:0012244)1.83377147
124Sex reversal (HP:0012245)1.83377147
125Abnormality of glycolipid metabolism (HP:0010969)1.81750401
126Abnormality of liposaccharide metabolism (HP:0010968)1.81750401
127Abnormality of glycosphingolipid metabolism (HP:0004343)1.81750401
128Patchy hypopigmentation of hair (HP:0011365)1.81430957
129Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80805860
130Dicarboxylic aciduria (HP:0003215)1.80805860
131Calf muscle hypertrophy (HP:0008981)1.80481059
132Methylmalonic aciduria (HP:0012120)1.77515105
133Heterochromia iridis (HP:0001100)1.77256273
134Thyroid carcinoma (HP:0002890)1.76228512
135Tetany (HP:0001281)1.76194466
136Abnormal biliary tract morphology (HP:0012440)1.76166374
137Malnutrition (HP:0004395)1.75925764
138Lower limb hyperreflexia (HP:0002395)1.74490403
139Hyperphosphaturia (HP:0003109)1.74173280
140Adrenal overactivity (HP:0002717)1.72383692
141Papillary thyroid carcinoma (HP:0002895)1.71700090
142Generalized hyperpigmentation (HP:0007440)1.70539551
143Absent eyebrow (HP:0002223)1.69891024
144Renal cortical cysts (HP:0000803)1.69315427
145Congenital sensorineural hearing impairment (HP:0008527)1.68242180
146Aplasia/Hypoplasia of the macula (HP:0008059)1.68113521
147Stomatitis (HP:0010280)1.67354703
148Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64558839
149Aplasia/hypoplasia of the uterus (HP:0008684)1.64541932
150Pancreatic fibrosis (HP:0100732)1.64296754
151Missing ribs (HP:0000921)1.64220399
152Glycosuria (HP:0003076)1.63803468
153Abnormality of urine glucose concentration (HP:0011016)1.63803468
154Abnormality of vitamin B metabolism (HP:0004340)1.61356831
155Small for gestational age (HP:0001518)1.58946039
156Tachypnea (HP:0002789)1.56698152
157Medial flaring of the eyebrow (HP:0010747)1.56404629
158Muscle hypertrophy of the lower extremities (HP:0008968)1.54791547
159Enlarged kidneys (HP:0000105)1.54551482
160Neoplasm of the thyroid gland (HP:0100031)1.53959991
161Febrile seizures (HP:0002373)1.52953787
162Abnormality of the renal cortex (HP:0011035)1.52604124
163Gaze-evoked nystagmus (HP:0000640)1.52502075
164White forelock (HP:0002211)1.51542528
165Anhidrosis (HP:0000970)1.50833927
166Poor suck (HP:0002033)1.49558860
167Urethral obstruction (HP:0000796)1.49422043
168Postural tremor (HP:0002174)1.48732098
169Anxiety (HP:0000739)1.47870391

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.64534523
2PASK5.99518250
3FGFR24.93044478
4MAPK153.91774476
5TAOK33.80387011
6PRKD33.54093018
7HIPK23.35961389
8MAP3K23.17124840
9FRK3.07263539
10FLT32.37378806
11ERN12.14762177
12IRAK32.07675807
13DAPK21.85697364
14WNK41.82966890
15SCYL21.71663572
16PHKG11.71520412
17PHKG21.71520412
18NTRK11.70502784
19ADRBK21.66771235
20CDC42BPA1.66630417
21EPHA31.63663683
22ACVR1B1.62271105
23IRAK11.61936444
24GRK11.59500574
25CASK1.58799327
26CAMKK21.57702918
27MST41.56954295
28PRKAA21.55923988
29PNCK1.50457246
30UHMK11.48660115
31NTRK31.46838733
32MAP3K11.46004875
33STK38L1.42282605
34AKT31.37766239
35PDGFRA1.34576218
36LIMK11.33332321
37EIF2AK31.32018953
38CSNK1G11.28524789
39CSNK1G31.23242710
40TRPM71.20316233
41WNK31.19567149
42CSNK1G21.17993559
43MKNK21.17431627
44STK241.17011045
45BRSK21.16963213
46PTK2B1.11387910
47PRKCH1.11384695
48PTK21.08571357
49OXSR11.05941268
50MET1.04973000
51TNIK1.02987641
52PTK61.01776141
53MAP3K40.99550565
54MAP4K20.98771713
55PRKCG0.98003132
56PRKD20.94688005
57DYRK1B0.92085657
58CAMK1G0.91550862
59STK110.87106567
60PINK10.86767757
61PAK30.85908453
62IRAK20.85369723
63MAP3K30.84745103
64TRIB30.84276347
65BMPR20.83929657
66BRD40.83711242
67MAP2K20.83004702
68NLK0.82072630
69PLK30.80045728
70BCKDK0.79521960
71PIK3CG0.78325647
72BRAF0.77136438
73PRKCE0.71931798
74MAP2K60.70872039
75NUAK10.70629160
76CDK30.69389052
77STK390.68881920
78YES10.67140461
79RET0.64135686
80ERBB30.63045391
81BMPR1B0.61558337
82WNK10.60794845
83ADRBK10.60354436
84PLK20.59964496
85IRAK40.59839335
86RPS6KA20.59508638
87TSSK60.57383943
88PRKAA10.55297518
89ITK0.55216641
90FER0.54955735
91STK30.54464965
92JAK20.52681885
93MAP2K70.52040988
94RPS6KA40.51625177
95FGFR40.51031815
96SIK10.50856114
97PRKCI0.50360380
98CAMK2D0.50082084
99PRKCZ0.49078017
100BRSK10.47853619
101CAMK10.46910658
102MAP3K70.46907962
103JAK30.46582054
104ROCK10.46257177
105FGFR30.46241666
106RPS6KB10.46023181
107STK160.45393406
108NEK60.44910830
109EPHA20.43705590
110GSK3A0.43120695
111CSNK1A1L0.41135178
112CSNK1A10.39846442
113JAK10.38790037
114CAMK2A0.36555404
115PRKD10.35224443
116ZAP700.34428937
117SGK20.34035571
118PRKACG0.34018365
119CSNK1D0.33911382
120CAMKK10.33489770
121TESK10.33232050
122IGF1R0.32444143
123CHUK0.31863204
124TEC0.30067388
125TAOK10.29985871
126SGK4940.29681946
127SGK2230.29681946
128MTOR0.27818312
129PRKDC0.27766565
130ROCK20.27691396
131CSNK1E0.27218270
132IKBKB0.26658005
133ATM0.25690378
134PRKACA0.25637485
135PDGFRB0.25012962
136VRK10.24379392
137MAPK140.23715575
138CAMK1D0.23285756
139MARK20.23140140
140AKT10.21760142
141CAMK2B0.21627301
142BCR0.21015150
143DYRK30.20999018
144OBSCN0.20565706
145CDK50.20260751
146EPHB10.20053394
147SGK30.18478414
148DYRK1A0.16268961
149PRKCA0.16259137
150MAPK30.14994814
151MAPK100.14989132
152RPS6KA30.14853873
153SGK10.13390181
154PRKG10.12712562

Predicted pathways (KEGG)

RankGene SetZ-score
1* Maturity onset diabetes of the young_Homo sapiens_hsa049508.77753732
2Protein export_Homo sapiens_hsa030606.43623417
3Sulfur metabolism_Homo sapiens_hsa009203.84296397
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.46025645
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.45983211
6Insulin secretion_Homo sapiens_hsa049113.23717475
7Type II diabetes mellitus_Homo sapiens_hsa049302.26212016
8Vibrio cholerae infection_Homo sapiens_hsa051102.17760973
9Type I diabetes mellitus_Homo sapiens_hsa049402.14029579
10Vitamin B6 metabolism_Homo sapiens_hsa007501.95795564
11Selenocompound metabolism_Homo sapiens_hsa004501.95175124
12Carbohydrate digestion and absorption_Homo sapiens_hsa049731.94302767
13N-Glycan biosynthesis_Homo sapiens_hsa005101.85203895
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.68376463
15Cocaine addiction_Homo sapiens_hsa050301.62177629
16Lysosome_Homo sapiens_hsa041421.58019776
17Fatty acid metabolism_Homo sapiens_hsa012121.47424419
18Other glycan degradation_Homo sapiens_hsa005111.44335563
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36753284
20Folate biosynthesis_Homo sapiens_hsa007901.29395490
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26164789
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23725020
23Oxidative phosphorylation_Homo sapiens_hsa001901.21904002
24Peroxisome_Homo sapiens_hsa041461.20989425
25Fatty acid degradation_Homo sapiens_hsa000711.19865000
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19653013
27Circadian rhythm_Homo sapiens_hsa047101.18482704
28Amphetamine addiction_Homo sapiens_hsa050311.16548973
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15140504
30Taste transduction_Homo sapiens_hsa047421.14556697
31Regulation of autophagy_Homo sapiens_hsa041401.14304666
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11645145
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06385180
34Insulin resistance_Homo sapiens_hsa049311.06089609
35Glucagon signaling pathway_Homo sapiens_hsa049221.03993564
36Galactose metabolism_Homo sapiens_hsa000521.01790510
37Thyroid hormone synthesis_Homo sapiens_hsa049181.01309345
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00317332
39Pancreatic secretion_Homo sapiens_hsa049720.99341556
40Propanoate metabolism_Homo sapiens_hsa006400.96921644
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90722434
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88002145
43Prolactin signaling pathway_Homo sapiens_hsa049170.86435196
44ABC transporters_Homo sapiens_hsa020100.86184465
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85177270
46Tryptophan metabolism_Homo sapiens_hsa003800.84627589
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84395475
48Collecting duct acid secretion_Homo sapiens_hsa049660.79865756
49Phototransduction_Homo sapiens_hsa047440.78606333
50Sphingolipid metabolism_Homo sapiens_hsa006000.77862128
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76603541
52Mineral absorption_Homo sapiens_hsa049780.75641750
53Prion diseases_Homo sapiens_hsa050200.75381068
54Dopaminergic synapse_Homo sapiens_hsa047280.74436454
55Ether lipid metabolism_Homo sapiens_hsa005650.72789461
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68151825
57Cholinergic synapse_Homo sapiens_hsa047250.66369671
58Steroid biosynthesis_Homo sapiens_hsa001000.66357397
59Butanoate metabolism_Homo sapiens_hsa006500.66240927
60Long-term potentiation_Homo sapiens_hsa047200.65124749
61Synaptic vesicle cycle_Homo sapiens_hsa047210.64026036
62Starch and sucrose metabolism_Homo sapiens_hsa005000.63403502
63Serotonergic synapse_Homo sapiens_hsa047260.60613267
64Estrogen signaling pathway_Homo sapiens_hsa049150.57949967
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57215725
66beta-Alanine metabolism_Homo sapiens_hsa004100.56982662
67Circadian entrainment_Homo sapiens_hsa047130.54927661
68Linoleic acid metabolism_Homo sapiens_hsa005910.53183381
69GABAergic synapse_Homo sapiens_hsa047270.52765448
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52571157
71Insulin signaling pathway_Homo sapiens_hsa049100.50785106
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49707232
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.48933589
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48716757
75Phenylalanine metabolism_Homo sapiens_hsa003600.48511152
76Antigen processing and presentation_Homo sapiens_hsa046120.47457214
77Alcoholism_Homo sapiens_hsa050340.47274779
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43522795
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43007972
80Nicotine addiction_Homo sapiens_hsa050330.41653489
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41315556
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.41259291
83Metabolic pathways_Homo sapiens_hsa011000.40506666
84Salivary secretion_Homo sapiens_hsa049700.39899127
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39778114
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38118560
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37681698
88RNA degradation_Homo sapiens_hsa030180.37185230
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36884235
90Histidine metabolism_Homo sapiens_hsa003400.35715565
91Long-term depression_Homo sapiens_hsa047300.35245087
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34582684
93AMPK signaling pathway_Homo sapiens_hsa041520.33760577
94Fatty acid biosynthesis_Homo sapiens_hsa000610.33349586
95mTOR signaling pathway_Homo sapiens_hsa041500.33177306
96Prostate cancer_Homo sapiens_hsa052150.32733958
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32216800
98Morphine addiction_Homo sapiens_hsa050320.31520848
99Thyroid cancer_Homo sapiens_hsa052160.30885444
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30210361
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29092243
102Rheumatoid arthritis_Homo sapiens_hsa053230.28950884
103Purine metabolism_Homo sapiens_hsa002300.28749913
104Renin secretion_Homo sapiens_hsa049240.28665013
105Inositol phosphate metabolism_Homo sapiens_hsa005620.27923020
106Fat digestion and absorption_Homo sapiens_hsa049750.27877661
107Fructose and mannose metabolism_Homo sapiens_hsa000510.27851892
108Lysine degradation_Homo sapiens_hsa003100.27711422
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26358787
110Arachidonic acid metabolism_Homo sapiens_hsa005900.25672495
111Basal transcription factors_Homo sapiens_hsa030220.24497886
112Nitrogen metabolism_Homo sapiens_hsa009100.24290636
113Tyrosine metabolism_Homo sapiens_hsa003500.24242154
114Dorso-ventral axis formation_Homo sapiens_hsa043200.24116502
115cAMP signaling pathway_Homo sapiens_hsa040240.22764560
116Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.21394678
117Phagosome_Homo sapiens_hsa041450.21150813
118Cardiac muscle contraction_Homo sapiens_hsa042600.20923689
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.19629025
120FoxO signaling pathway_Homo sapiens_hsa040680.19481261
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18326710
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.17566723
123Protein digestion and absorption_Homo sapiens_hsa049740.16248854
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16219722
125Legionellosis_Homo sapiens_hsa051340.15287755
126Ovarian steroidogenesis_Homo sapiens_hsa049130.14997368
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.14756734
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.10971734
129Melanogenesis_Homo sapiens_hsa049160.09655297
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.09103297
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.07138260
132Bladder cancer_Homo sapiens_hsa052190.07064595
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.06986777
134Endometrial cancer_Homo sapiens_hsa052130.06233549
135Fatty acid elongation_Homo sapiens_hsa000620.05560866
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.04899475

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