IARS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.57380267
2nuclear pore complex assembly (GO:0051292)5.45913397
3DNA unwinding involved in DNA replication (GO:0006268)5.14295969
4folic acid-containing compound biosynthetic process (GO:0009396)5.03520693
5protein localization to kinetochore (GO:0034501)5.02169819
6mitotic nuclear envelope disassembly (GO:0007077)4.74362509
7IMP biosynthetic process (GO:0006188)4.55423704
8nuclear envelope disassembly (GO:0051081)4.47211824
9membrane disassembly (GO:0030397)4.47211824
10establishment of integrated proviral latency (GO:0075713)4.36426882
11IMP metabolic process (GO:0046040)4.17241641
12* regulation of translational fidelity (GO:0006450)4.15543360
13L-serine metabolic process (GO:0006563)4.14458913
14pre-miRNA processing (GO:0031054)4.14198327
15nucleobase biosynthetic process (GO:0046112)4.06399525
16DNA replication initiation (GO:0006270)4.03776131
17protein localization to chromosome, centromeric region (GO:0071459)4.03234036
18mitotic metaphase plate congression (GO:0007080)4.02041094
19formation of translation preinitiation complex (GO:0001731)4.00400342
20heterochromatin organization (GO:0070828)3.99997429
21pore complex assembly (GO:0046931)3.99139804
22double-strand break repair via nonhomologous end joining (GO:0006303)3.97980795
23non-recombinational repair (GO:0000726)3.97980795
24regulation of spindle organization (GO:0090224)3.90899576
25DNA replication-dependent nucleosome assembly (GO:0006335)3.88702291
26DNA replication-dependent nucleosome organization (GO:0034723)3.88702291
27mitotic chromosome condensation (GO:0007076)3.86126961
28mitotic sister chromatid segregation (GO:0000070)3.85883174
29positive regulation of chromosome segregation (GO:0051984)3.81607313
30sister chromatid segregation (GO:0000819)3.80609387
31DNA geometric change (GO:0032392)3.79865416
32DNA duplex unwinding (GO:0032508)3.79296216
33regulation of gene silencing by RNA (GO:0060966)3.78915041
34regulation of posttranscriptional gene silencing (GO:0060147)3.78915041
35regulation of gene silencing by miRNA (GO:0060964)3.78915041
36regulation of translational termination (GO:0006449)3.78749966
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.77014847
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.76246159
39ribosome assembly (GO:0042255)3.72943162
40DNA strand elongation involved in DNA replication (GO:0006271)3.65320125
41mitotic sister chromatid cohesion (GO:0007064)3.63558429
42negative regulation of histone methylation (GO:0031061)3.63122777
43telomere maintenance via recombination (GO:0000722)3.60444927
44nuclear envelope organization (GO:0006998)3.55219444
45metaphase plate congression (GO:0051310)3.54905574
46regulation of mitotic spindle organization (GO:0060236)3.50101707
47purine nucleobase biosynthetic process (GO:0009113)3.49877578
48DNA strand elongation (GO:0022616)3.45686452
49regulation of histone H3-K9 methylation (GO:0051570)3.43151460
50DNA topological change (GO:0006265)3.42951369
51establishment of viral latency (GO:0019043)3.34612883
52regulation of RNA export from nucleus (GO:0046831)3.32201244
53DNA replication checkpoint (GO:0000076)3.30262670
54positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.25924879
55positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.25924879
56positive regulation of mitotic sister chromatid separation (GO:1901970)3.25924879
57histone H2A monoubiquitination (GO:0035518)3.25679219
58protein complex localization (GO:0031503)3.19580511
59attachment of spindle microtubules to kinetochore (GO:0008608)3.18281558
60COPI coating of Golgi vesicle (GO:0048205)3.16545974
61Golgi transport vesicle coating (GO:0048200)3.16545974
62maturation of SSU-rRNA (GO:0030490)3.16417732
63ribosome biogenesis (GO:0042254)3.16149220
64DNA ligation (GO:0006266)3.13753364
65establishment of chromosome localization (GO:0051303)3.13599504
66protein localization to chromosome (GO:0034502)3.12769175
67regulation of sister chromatid cohesion (GO:0007063)3.10851009
68regulation of chromosome segregation (GO:0051983)3.09674280
69chromatin assembly (GO:0031497)3.08785132
70cellular protein complex localization (GO:0034629)3.08482115
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08451454
72regulation of centrosome cycle (GO:0046605)3.08050325
73histone exchange (GO:0043486)3.07719656
74peptidyl-arginine omega-N-methylation (GO:0035247)3.05488021
75negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.04547058
76paraxial mesoderm development (GO:0048339)3.04353457
77telomere maintenance via telomere lengthening (GO:0010833)3.03815471
78negative regulation of chromosome segregation (GO:0051985)3.03191512
79somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02604015
80somatic hypermutation of immunoglobulin genes (GO:0016446)3.02604015
81spindle checkpoint (GO:0031577)3.02529913
82DNA conformation change (GO:0071103)3.02393577
83nucleobase-containing small molecule interconversion (GO:0015949)3.01532052
84tetrahydrofolate metabolic process (GO:0046653)2.99505487
85kinetochore organization (GO:0051383)2.99149873
86spliceosomal tri-snRNP complex assembly (GO:0000244)2.98463546
87positive regulation of SMAD protein import into nucleus (GO:0060391)2.97640956
88telomere maintenance via semi-conservative replication (GO:0032201)2.97217543
89spindle assembly checkpoint (GO:0071173)2.96771162
90dosage compensation (GO:0007549)2.96407143
91mitotic spindle checkpoint (GO:0071174)2.94734857
92glutamine metabolic process (GO:0006541)2.94562606
93negative regulation of mitotic sister chromatid separation (GO:2000816)2.94535874
94negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94535874
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94535874
96negative regulation of sister chromatid segregation (GO:0033046)2.94535874
97mitotic spindle assembly checkpoint (GO:0007094)2.94430257
98mRNA transport (GO:0051028)2.93874422
99regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92587676
100proline biosynthetic process (GO:0006561)2.92546590
101DNA strand renaturation (GO:0000733)2.91619117
102chromosome segregation (GO:0007059)2.90617709
103* tRNA aminoacylation for protein translation (GO:0006418)2.89009898
104chromatin remodeling at centromere (GO:0031055)2.88898815
105nucleotide-excision repair, DNA gap filling (GO:0006297)2.88851010
106protein K6-linked ubiquitination (GO:0085020)2.88817837
107DNA synthesis involved in DNA repair (GO:0000731)2.86889765
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.86260798
109regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.86237577
110regulation of centrosome duplication (GO:0010824)2.85981803
111chromatin assembly or disassembly (GO:0006333)2.84525113
112DNA replication-independent nucleosome assembly (GO:0006336)2.82104202
113DNA replication-independent nucleosome organization (GO:0034724)2.82104202
114proteasome assembly (GO:0043248)2.81970269
115regulation of centriole replication (GO:0046599)2.81114244
116regulation of sister chromatid segregation (GO:0033045)2.80933356
117regulation of mitotic sister chromatid separation (GO:0010965)2.80933356
118regulation of mitotic sister chromatid segregation (GO:0033047)2.80933356
119serine family amino acid biosynthetic process (GO:0009070)2.80848257
120negative regulation of DNA repair (GO:0045738)2.80371923
121CENP-A containing nucleosome assembly (GO:0034080)2.79014371
122telomere maintenance (GO:0000723)2.78679198
123regulation of helicase activity (GO:0051095)2.78579296
124* amino acid activation (GO:0043038)2.78506169
125* tRNA aminoacylation (GO:0043039)2.78506169
126mitotic recombination (GO:0006312)2.77545021

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.19973794
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.82438256
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.13661256
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.70878193
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22352209
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.14273200
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.10863938
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03073340
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70633503
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.65511839
11AR_21909140_ChIP-Seq_LNCAP_Human2.53216703
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.41451262
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32531012
14MYC_22102868_ChIP-Seq_BL_Human2.20461168
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.11100737
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.08738637
17* XRN2_22483619_ChIP-Seq_HELA_Human2.07075603
18MYCN_18555785_ChIP-Seq_MESCs_Mouse2.04775187
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.99097208
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93142076
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93136401
22* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92560999
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91323644
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.89119582
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83216753
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83171615
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81901539
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77293733
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.71808823
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68456246
31YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67058333
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.64905589
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64715184
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.63672850
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61949122
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61353301
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59022139
38* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58801760
39KDM5A_27292631_Chip-Seq_BREAST_Human1.58339354
40VDR_23849224_ChIP-Seq_CD4+_Human1.58294817
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57015265
42CIITA_25753668_ChIP-Seq_RAJI_Human1.55228291
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53084106
44TTF2_22483619_ChIP-Seq_HELA_Human1.51758320
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48971108
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48971108
47KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48971108
48GABP_19822575_ChIP-Seq_HepG2_Human1.48637257
49FOXP3_21729870_ChIP-Seq_TREG_Human1.48113677
50DCP1A_22483619_ChIP-Seq_HELA_Human1.46559696
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46210423
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43789798
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43600618
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41613761
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39309710
56TFEB_21752829_ChIP-Seq_HELA_Human1.38838797
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37244797
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.35565588
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34411871
60ELK1_19687146_ChIP-ChIP_HELA_Human1.33733094
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33176036
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.30932437
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30726187
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29426852
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25040839
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.22087549
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21218316
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20110380
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20035790
70SOX17_20123909_ChIP-Seq_XEN_Mouse1.19929684
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19587608
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17265056
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16123263
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15626674
75NANOG_21062744_ChIP-ChIP_HESCs_Human1.15477318
76CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14477340
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13064926
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12502932
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11706539
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11298190
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11008300
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07930183
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07054648
84NANOG_16153702_ChIP-ChIP_HESCs_Human1.06090171
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05591581
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05585650
87TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05381856
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04648035
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04550892
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04527858
91CHD1_26751641_Chip-Seq_LNCaP_Human1.04226882
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03553156
93HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03094544
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00818796
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96800664
96SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95435602
97VDR_21846776_ChIP-Seq_THP-1_Human0.95053229
98* ATF3_27146783_Chip-Seq_COLON_Human0.93702721
99ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93426905
100* MYC_18940864_ChIP-ChIP_HL60_Human0.92992681
101* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92450296
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91839388
103WT1_19549856_ChIP-ChIP_CCG9911_Human0.91637013
104EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91288908
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91256061
106ZNF263_19887448_ChIP-Seq_K562_Human0.89126614
107YY1_21170310_ChIP-Seq_MESCs_Mouse0.89069329
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88480242
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88383043
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87872685
111TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87729325
112NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.86663228
113CLOCK_20551151_ChIP-Seq_293T_Human0.86584674
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86217272
115TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86000827
116* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85600708
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84267229
118SOX2_16153702_ChIP-ChIP_HESCs_Human0.81340200
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80065021
120* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75418264
121GATA4_21415370_ChIP-Seq_HL-1_Mouse0.75027999
122TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73846047
123* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.71002921
124NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.70395589

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.95419473
2MP0004957_abnormal_blastocyst_morpholog3.89209067
3MP0010094_abnormal_chromosome_stability3.78862037
4MP0003111_abnormal_nucleus_morphology3.73847178
5MP0010352_gastrointestinal_tract_polyps3.46283109
6MP0003077_abnormal_cell_cycle3.44459353
7MP0008057_abnormal_DNA_replication3.39119787
8MP0001730_embryonic_growth_arrest2.71241222
9MP0003123_paternal_imprinting2.63452752
10MP0003705_abnormal_hypodermis_morpholog2.44212756
11MP0000350_abnormal_cell_proliferation2.36525501
12MP0009697_abnormal_copulation2.34696633
13MP0005076_abnormal_cell_differentiation2.26344695
14MP0008932_abnormal_embryonic_tissue2.23093717
15MP0008007_abnormal_cellular_replicative2.21463822
16MP0010307_abnormal_tumor_latency2.17612013
17MP0008058_abnormal_DNA_repair2.16613365
18MP0001672_abnormal_embryogenesis/_devel2.13039887
19MP0005380_embryogenesis_phenotype2.13039887
20MP0004197_abnormal_fetal_growth/weight/2.06318551
21MP0010030_abnormal_orbit_morphology2.01710467
22MP0002084_abnormal_developmental_patter2.01590781
23MP0003984_embryonic_growth_retardation1.99288664
24MP0001697_abnormal_embryo_size1.97666906
25MP0002088_abnormal_embryonic_growth/wei1.96056679
26MP0002085_abnormal_embryonic_tissue1.91305627
27MP0002086_abnormal_extraembryonic_tissu1.81976974
28MP0002396_abnormal_hematopoietic_system1.81628837
29MP0000537_abnormal_urethra_morphology1.81219109
30MP0002080_prenatal_lethality1.75005124
31MP0003890_abnormal_embryonic-extraembry1.73541579
32MP0003121_genomic_imprinting1.67937966
33MP0008877_abnormal_DNA_methylation1.64659916
34MP0004272_abnormal_basement_membrane1.62565943
35MP0003567_abnormal_fetal_cardiomyocyte1.60255914
36MP0001661_extended_life_span1.53802094
37MP0003566_abnormal_cell_adhesion1.53137439
38MP0003806_abnormal_nucleotide_metabolis1.50930965
39MP0001293_anophthalmia1.46505152
40MP0004233_abnormal_muscle_weight1.34519735
41MP0000733_abnormal_muscle_development1.32103032
42MP0004264_abnormal_extraembryonic_tissu1.31746692
43MP0005023_abnormal_wound_healing1.31368575
44MP0009053_abnormal_anal_canal1.30330233
45MP0003937_abnormal_limbs/digits/tail_de1.29712260
46MP0002877_abnormal_melanocyte_morpholog1.29214511
47MP0004808_abnormal_hematopoietic_stem1.28201434
48MP0001849_ear_inflammation1.26635244
49MP0009672_abnormal_birth_weight1.23649499
50MP0003119_abnormal_digestive_system1.21246443
51MP0000313_abnormal_cell_death1.18627925
52MP0000490_abnormal_crypts_of1.18239565
53MP0001915_intracranial_hemorrhage1.18074003
54MP0002111_abnormal_tail_morphology1.15783212
55MP0000428_abnormal_craniofacial_morphol1.14905147
56MP0009703_decreased_birth_body1.11820834
57MP0001299_abnormal_eye_distance/1.11581863
58MP0002019_abnormal_tumor_incidence1.09111100
59MP0006054_spinal_hemorrhage1.07869877
60MP0005623_abnormal_meninges_morphology1.07036127
61MP0002060_abnormal_skin_morphology1.06833092
62MP0003786_premature_aging1.06333142
63MP0002697_abnormal_eye_size1.03662168
64MP0003385_abnormal_body_wall1.01813111
65MP0002009_preneoplasia1.00606345
66MP0006035_abnormal_mitochondrial_morpho0.97324517
67MP0000579_abnormal_nail_morphology0.94306416
68MP0005408_hypopigmentation0.93999014
69MP0003718_maternal_effect0.93569635
70MP0008438_abnormal_cutaneous_collagen0.92809549
71MP0002925_abnormal_cardiovascular_devel0.92696011
72MP0005621_abnormal_cell_physiology0.92106456
73MP0004133_heterotaxia0.91476795
74MP0005501_abnormal_skin_physiology0.91423145
75MP0000432_abnormal_head_morphology0.90420520
76MP0002092_abnormal_eye_morphology0.90077752
77MP0010234_abnormal_vibrissa_follicle0.90042723
78MP0002653_abnormal_ependyma_morphology0.88703306
79MP0005384_cellular_phenotype0.88525012
80MP0003115_abnormal_respiratory_system0.85343845
81MP0003935_abnormal_craniofacial_develop0.85059783
82MP0003315_abnormal_perineum_morphology0.84530444
83MP0003283_abnormal_digestive_organ0.84469425
84MP0001286_abnormal_eye_development0.80554143
85MP0002269_muscular_atrophy0.80448155
86MP0002233_abnormal_nose_morphology0.79921189
87MP0000762_abnormal_tongue_morphology0.79581795
88MP0002210_abnormal_sex_determination0.78959941
89MP0002938_white_spotting0.78365389
90MP0008770_decreased_survivor_rate0.76457177
91MP0009278_abnormal_bone_marrow0.76098029
92MP0003221_abnormal_cardiomyocyte_apopto0.75724963
93MP0001145_abnormal_male_reproductive0.75540413
94MP0004185_abnormal_adipocyte_glucose0.73035995
95MP0000266_abnormal_heart_morphology0.72940047
96MP0003950_abnormal_plasma_membrane0.72938298
97MP0003755_abnormal_palate_morphology0.72014524
98MP0000703_abnormal_thymus_morphology0.70762718
99MP0001881_abnormal_mammary_gland0.70609530
100MP0002796_impaired_skin_barrier0.70431968
101MP0001243_abnormal_dermal_layer0.68248867
102MP0003941_abnormal_skin_development0.68198408
103MP0004084_abnormal_cardiac_muscle0.67860018
104MP0000647_abnormal_sebaceous_gland0.67751480
105MP0000516_abnormal_urinary_system0.67695956
106MP0005367_renal/urinary_system_phenotyp0.67695956
107MP0003861_abnormal_nervous_system0.67171448
108MP0000358_abnormal_cell_content/0.67075534
109MP0001929_abnormal_gametogenesis0.67003015
110MP0005257_abnormal_intraocular_pressure0.66857846
111MP0010630_abnormal_cardiac_muscle0.66447141
112MP0002114_abnormal_axial_skeleton0.65546431
113MP0000627_abnormal_mammary_gland0.64377553
114MP0002932_abnormal_joint_morphology0.63605622
115MP0003091_abnormal_cell_migration0.62191703
116MP0003186_abnormal_redox_activity0.62031754
117MP0000653_abnormal_sex_gland0.61932366
118MP0000377_abnormal_hair_follicle0.61259395
119MP0003942_abnormal_urinary_system0.61253940
120MP0000477_abnormal_intestine_morphology0.61065417
121MP0000750_abnormal_muscle_regeneration0.60677656
122MP0005397_hematopoietic_system_phenotyp0.60296045
123MP0001545_abnormal_hematopoietic_system0.60296045
124MP0002234_abnormal_pharynx_morphology0.60020734
125MP0002254_reproductive_system_inflammat0.59426734
126MP0005395_other_phenotype0.59092879
127MP0009333_abnormal_splenocyte_physiolog0.58635622

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.09445153
2Medulloblastoma (HP:0002885)3.48018258
3Abnormality of the astrocytes (HP:0100707)3.20630653
4Astrocytoma (HP:0009592)3.20630653
5Colon cancer (HP:0003003)3.15302022
6Birth length less than 3rd percentile (HP:0003561)3.14523708
7Abnormality of the labia minora (HP:0012880)3.13900082
8Selective tooth agenesis (HP:0001592)3.12042279
9Deviation of the thumb (HP:0009603)3.04486332
10Proximal placement of thumb (HP:0009623)2.96078388
11Abnormality of glycolysis (HP:0004366)2.88523157
12Rhabdomyosarcoma (HP:0002859)2.87576267
13Nephroblastoma (Wilms tumor) (HP:0002667)2.76499947
14Neoplasm of the oral cavity (HP:0100649)2.64927014
15Chromsome breakage (HP:0040012)2.64887511
16Multiple enchondromatosis (HP:0005701)2.64640419
17Embryonal renal neoplasm (HP:0011794)2.64515596
18Glioma (HP:0009733)2.64381617
19Degeneration of anterior horn cells (HP:0002398)2.57923326
20Abnormality of the anterior horn cell (HP:0006802)2.57923326
21Breast hypoplasia (HP:0003187)2.56099473
22Increased serum pyruvate (HP:0003542)2.55097390
23Patellar aplasia (HP:0006443)2.52407610
24Upper limb muscle weakness (HP:0003484)2.50976113
25Increased nuchal translucency (HP:0010880)2.50334519
26Abnormality of the calcaneus (HP:0008364)2.49174028
27Missing ribs (HP:0000921)2.44063355
28Absent radius (HP:0003974)2.40586194
29Short 4th metacarpal (HP:0010044)2.39586323
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.39586323
31Neoplasm of striated muscle (HP:0009728)2.38538365
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.36588571
33Volvulus (HP:0002580)2.36402497
34Microvesicular hepatic steatosis (HP:0001414)2.35046602
35Aplasia/Hypoplasia of the patella (HP:0006498)2.32042682
36Basal cell carcinoma (HP:0002671)2.29572491
37Protrusio acetabuli (HP:0003179)2.29163214
38Agnosia (HP:0010524)2.27271897
39Abnormal number of incisors (HP:0011064)2.25556647
40Biliary tract neoplasm (HP:0100574)2.24778767
41Abnormality of the umbilical cord (HP:0010881)2.24377487
42Abnormality of chromosome stability (HP:0003220)2.23845507
43Ectopic kidney (HP:0000086)2.22398281
44Aplasia involving forearm bones (HP:0009822)2.20697386
45Absent forearm bone (HP:0003953)2.20697386
46Abnormality of methionine metabolism (HP:0010901)2.19268695
47Premature rupture of membranes (HP:0001788)2.19093156
48Abnormality of the carotid arteries (HP:0005344)2.18271172
49Impulsivity (HP:0100710)2.13326807
50Short humerus (HP:0005792)2.12874445
51Aplasia/hypoplasia of the humerus (HP:0006507)2.11771154
52Facial hemangioma (HP:0000329)2.10416176
53Spastic diplegia (HP:0001264)2.06504597
54Myelodysplasia (HP:0002863)2.03455366
55Increased density of long bones (HP:0006392)2.02891452
56Rib fusion (HP:0000902)2.02000099
57Progressive external ophthalmoplegia (HP:0000590)2.01331113
58Long eyelashes (HP:0000527)2.01024786
59Cafe-au-lait spot (HP:0000957)2.00310039
60Atresia of the external auditory canal (HP:0000413)1.99852695
61Absent thumb (HP:0009777)1.99694430
62Ankle contracture (HP:0006466)1.99387667
63Carpal bone hypoplasia (HP:0001498)1.99301969
64Malignant gastrointestinal tract tumors (HP:0006749)1.99077941
65Gastrointestinal carcinoma (HP:0002672)1.99077941
66Reticulocytopenia (HP:0001896)1.98896261
67Esophageal atresia (HP:0002032)1.98577479
68Abnormalities of placenta or umbilical cord (HP:0001194)1.98216739
69Abnormality of abdominal situs (HP:0011620)1.97302256
70Abdominal situs inversus (HP:0003363)1.97302256
71Urethral obstruction (HP:0000796)1.96295515
72Squamous cell carcinoma (HP:0002860)1.93556475
73Meckel diverticulum (HP:0002245)1.92227600
74Shallow orbits (HP:0000586)1.91793368
75Abnormality of the fetal cardiovascular system (HP:0010948)1.91078555
76Abnormal umbilical cord blood vessels (HP:0011403)1.91078555
77Single umbilical artery (HP:0001195)1.91078555
78Cholecystitis (HP:0001082)1.90951865
79Abnormal gallbladder physiology (HP:0012438)1.90951865
80Pelvic girdle muscle weakness (HP:0003749)1.90935305
81Deep philtrum (HP:0002002)1.90761625
82Neoplasm of the pancreas (HP:0002894)1.90746041
83Aplasia/Hypoplasia of the sternum (HP:0006714)1.90366203
84Choanal atresia (HP:0000453)1.90325177
85Microglossia (HP:0000171)1.90076005
86Trismus (HP:0000211)1.89897837
87Facial cleft (HP:0002006)1.89087154
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.88838328
89Breech presentation (HP:0001623)1.88534004
90Progressive muscle weakness (HP:0003323)1.88173886
91Ankyloglossia (HP:0010296)1.86493608
92Small intestinal stenosis (HP:0012848)1.85738266
93Duodenal stenosis (HP:0100867)1.85738266
94Prominent nose (HP:0000448)1.84722679
95Broad thumb (HP:0011304)1.83356558
96High pitched voice (HP:0001620)1.83239681
97Pancreatic islet-cell hyperplasia (HP:0004510)1.82487538
98Abnormality of the 4th metacarpal (HP:0010012)1.82096095
99Vertebral clefting (HP:0008428)1.80763648
100Sloping forehead (HP:0000340)1.80649085
101Metaphyseal cupping (HP:0003021)1.80554254
102Abnormality of the ileum (HP:0001549)1.80439116
103Oral leukoplakia (HP:0002745)1.80059989
104Amaurosis fugax (HP:0100576)1.79335314
105Cortical dysplasia (HP:0002539)1.79126317
106Ovarian neoplasm (HP:0100615)1.79014738
107Overlapping toe (HP:0001845)1.78523641
108Short middle phalanx of the 5th finger (HP:0004220)1.78391063
109Skull defect (HP:0001362)1.76850633
110Abnormality of the preputium (HP:0100587)1.75623518
111Ulnar bowing (HP:0003031)1.74706353
112Postnatal microcephaly (HP:0005484)1.73928034
113Cerebral hypomyelination (HP:0006808)1.72908353
114Pterygium (HP:0001059)1.72446944
115Supernumerary spleens (HP:0009799)1.71530163
116Genu recurvatum (HP:0002816)1.71446679
117Adenoma sebaceum (HP:0009720)1.70041835
118Angiofibromas (HP:0010615)1.70041835
119Skin tags (HP:0010609)1.69902069
120Slender long bone (HP:0003100)1.69198272
121Hypoplasia of the pons (HP:0012110)1.68872059
122Cutaneous melanoma (HP:0012056)1.68001659
123Abnormality of the pons (HP:0007361)1.67284614
124Long foot (HP:0001833)1.66070154
125Large hands (HP:0001176)1.65790791
126Duplicated collecting system (HP:0000081)1.65640822
127Uterine neoplasm (HP:0010784)1.65005191
128Shoulder girdle muscle weakness (HP:0003547)1.64255746
129Reduced antithrombin III activity (HP:0001976)1.64223241
130Asymmetry of the thorax (HP:0001555)1.63697065
131Abnormality of the duodenum (HP:0002246)1.62797061
132Heterotopia (HP:0002282)1.62440519
133Insomnia (HP:0100785)1.62165448
134Abnormal lung lobation (HP:0002101)1.61928385
135Entropion (HP:0000621)1.61599208
136Preauricular skin tag (HP:0000384)1.61171777
137Pseudobulbar signs (HP:0002200)1.61032319
138Arteriovenous malformation (HP:0100026)1.60847140
139Neoplasm of the colon (HP:0100273)1.60839981
140Abnormality of oral frenula (HP:0000190)1.60248928
141Secondary amenorrhea (HP:0000869)1.59634844
142Horseshoe kidney (HP:0000085)1.57233161
143Insidious onset (HP:0003587)1.55707530
144Termporal pattern (HP:0011008)1.55707530
145Neuroblastoma (HP:0003006)1.54962013
146Primitive neuroectodermal tumor (HP:0030065)1.54962013
147Neuroblastic tumors (HP:0004376)1.54962013
148Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.54962013
149Megaloblastic anemia (HP:0001889)1.54291670
150Embryonal neoplasm (HP:0002898)1.52761362
151Acute myeloid leukemia (HP:0004808)1.52363925
152Type I transferrin isoform profile (HP:0003642)1.52298713
153Breast carcinoma (HP:0003002)1.50827075
154Duplication of thumb phalanx (HP:0009942)1.50662989
155Neoplasm of the small intestine (HP:0100833)1.50591685
156Abnormality of the intrinsic pathway (HP:0010989)1.46723838
157Neuroepithelial neoplasm (HP:0030063)1.46167449
158Nervous tissue neoplasm (HP:0030060)1.46167449

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.06510733
2CDK123.84754362
3PBK3.43507940
4EEF2K3.04551696
5WEE12.96796428
6BUB12.79836186
7TTK2.68208794
8NEK12.64370412
9NEK22.56551862
10TSSK62.55128676
11EPHA22.25609992
12RPS6KB22.10660487
13PASK2.03027646
14PKN22.02273405
15STK101.96487012
16MAP3K101.92197572
17EIF2AK11.82432901
18TAF11.77131783
19SCYL21.76189102
20MAP3K81.71622141
21MST41.71549146
22BRD41.70672238
23ZAK1.69731169
24MST1R1.65853876
25LATS11.64699991
26BRSK21.64420735
27PLK11.63526625
28PLK31.62355791
29ATR1.54087227
30CDK71.53851881
31CHEK11.53355226
32CDK41.51178554
33VRK21.49430376
34RPS6KA41.48473569
35SMG11.47883441
36ALK1.45642736
37MKNK11.43754761
38AURKB1.39768304
39TRIM281.39363052
40TESK21.30394593
41CHEK21.30311135
42TTN1.30015897
43MTOR1.28357928
44PDK21.26870854
45STK31.25462066
46SRPK11.22240348
47LATS21.18639459
48EIF2AK21.17422636
49PAK41.16498020
50CDK61.14705040
51TRIB31.11148545
52ATM1.06586978
53FLT31.05204518
54TGFBR11.04523193
55PNCK1.02732960
56ACVR1B1.02555629
57CDK21.01724019
58PLK41.01709991
59MET1.01133140
60EIF2AK31.00595992
61AURKA0.96460759
62PAK20.95283052
63FGFR10.93859915
64STK40.90594779
65NUAK10.87808318
66LRRK20.87235442
67MAP2K30.85445798
68MELK0.83089913
69BRSK10.80413654
70CLK10.80399538
71BCR0.79042902
72NME10.76945739
73CDK10.75879230
74DYRK30.71583394
75ERBB30.71180656
76PIM10.69772100
77ICK0.69388339
78CCNB10.68272720
79MKNK20.68208506
80CSNK1E0.67160118
81CDK80.66958060
82PDGFRA0.66090526
83BRAF0.65786218
84BMX0.64439522
85PAK10.63877221
86CSNK1D0.62989613
87CSNK2A20.60334514
88STK38L0.58832382
89STK160.55954993
90ERBB40.53052289
91AKT20.52961001
92PLK20.52557763
93AKT30.52452554
94PTK60.50335336
95PRKDC0.49915793
96VRK10.49856009
97CAMK1G0.48848422
98MAP3K30.45012803
99DDR20.44941846
100NEK90.44192917
101MAPK140.43027974
102PRKCI0.42138955
103CSNK1G10.41775962
104MAPKAPK30.41127407
105MAPK10.40422847
106RAF10.39198640
107MAPKAPK50.39084393
108DAPK10.38584628
109PTK20.37856302
110CSNK1A1L0.36338997
111CSNK2A10.36245004
112CAMK1D0.34232367
113GSK3B0.32817837
114IRAK30.32085872
115RPS6KA50.31615435
116STK390.30944245
117LIMK10.30912054
118TESK10.29826847
119AKT10.29156471
120PDK40.28688485
121PDK30.28688485
122TAOK20.27562901
123RPS6KB10.27319523
124CDK90.26814594
125NME20.26079381
126MAPKAPK20.25617495
127MARK30.25539836
128CHUK0.24951452
129PDGFRB0.23446723

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.11900512
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.75616970
3Mismatch repair_Homo sapiens_hsa034303.67505534
4One carbon pool by folate_Homo sapiens_hsa006703.66211779
5* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.57129870
6RNA transport_Homo sapiens_hsa030133.56243382
7Spliceosome_Homo sapiens_hsa030403.01874023
8Cell cycle_Homo sapiens_hsa041102.98871373
9Base excision repair_Homo sapiens_hsa034102.47376288
10Nucleotide excision repair_Homo sapiens_hsa034202.41164930
11mRNA surveillance pathway_Homo sapiens_hsa030152.28034267
12Homologous recombination_Homo sapiens_hsa034402.19280549
13RNA degradation_Homo sapiens_hsa030181.94122358
14RNA polymerase_Homo sapiens_hsa030201.93777887
15Non-homologous end-joining_Homo sapiens_hsa034501.90032362
16Fanconi anemia pathway_Homo sapiens_hsa034601.81282960
17p53 signaling pathway_Homo sapiens_hsa041151.68594762
18Pyruvate metabolism_Homo sapiens_hsa006201.64260494
19Proteasome_Homo sapiens_hsa030501.60058352
20Basal transcription factors_Homo sapiens_hsa030221.48580432
21Biosynthesis of amino acids_Homo sapiens_hsa012301.46508127
22Protein export_Homo sapiens_hsa030601.42619338
23Ribosome_Homo sapiens_hsa030101.41783098
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.41494593
25Pyrimidine metabolism_Homo sapiens_hsa002401.35761222
26MicroRNAs in cancer_Homo sapiens_hsa052061.35361244
27Selenocompound metabolism_Homo sapiens_hsa004501.30681413
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30345661
29Viral carcinogenesis_Homo sapiens_hsa052031.30257317
30Propanoate metabolism_Homo sapiens_hsa006401.18281857
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17459091
32Epstein-Barr virus infection_Homo sapiens_hsa051691.14021525
33Steroid biosynthesis_Homo sapiens_hsa001001.12115569
34Hippo signaling pathway_Homo sapiens_hsa043901.09426639
35Oocyte meiosis_Homo sapiens_hsa041141.08574433
36HTLV-I infection_Homo sapiens_hsa051661.05162967
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.04518895
38Small cell lung cancer_Homo sapiens_hsa052221.04088053
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.03139856
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00756398
41TGF-beta signaling pathway_Homo sapiens_hsa043500.99550991
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99003539
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98849534
44Thyroid cancer_Homo sapiens_hsa052160.98171241
45Adherens junction_Homo sapiens_hsa045200.95341047
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.94182991
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92537884
48Chronic myeloid leukemia_Homo sapiens_hsa052200.90510806
49mTOR signaling pathway_Homo sapiens_hsa041500.89853414
50Fatty acid elongation_Homo sapiens_hsa000620.89215623
51Basal cell carcinoma_Homo sapiens_hsa052170.89176192
52Systemic lupus erythematosus_Homo sapiens_hsa053220.81978114
53Antigen processing and presentation_Homo sapiens_hsa046120.81611598
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80764269
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80529100
56Bladder cancer_Homo sapiens_hsa052190.80267335
57Colorectal cancer_Homo sapiens_hsa052100.77913215
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76979855
59Lysine degradation_Homo sapiens_hsa003100.74753149
60Carbon metabolism_Homo sapiens_hsa012000.74314531
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73605303
62Herpes simplex infection_Homo sapiens_hsa051680.72325526
63Tight junction_Homo sapiens_hsa045300.70065608
64Proteoglycans in cancer_Homo sapiens_hsa052050.69094022
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68725192
66Prostate cancer_Homo sapiens_hsa052150.66461070
67Pentose phosphate pathway_Homo sapiens_hsa000300.65231622
68Notch signaling pathway_Homo sapiens_hsa043300.64919719
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64535220
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63071856
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62930411
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61737978
73HIF-1 signaling pathway_Homo sapiens_hsa040660.60682433
74Purine metabolism_Homo sapiens_hsa002300.60663940
75Hedgehog signaling pathway_Homo sapiens_hsa043400.59648001
76Viral myocarditis_Homo sapiens_hsa054160.59322587
77Legionellosis_Homo sapiens_hsa051340.58937034
78Glutathione metabolism_Homo sapiens_hsa004800.56520878
79Fatty acid metabolism_Homo sapiens_hsa012120.54380926
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53949891
81Pathways in cancer_Homo sapiens_hsa052000.53718463
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53211440
83Arginine biosynthesis_Homo sapiens_hsa002200.50672433
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50271812
85Apoptosis_Homo sapiens_hsa042100.49820825
86ECM-receptor interaction_Homo sapiens_hsa045120.49640117
87Focal adhesion_Homo sapiens_hsa045100.48606185
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47444562
89Hepatitis B_Homo sapiens_hsa051610.47247959
90Vitamin B6 metabolism_Homo sapiens_hsa007500.46162374
91Shigellosis_Homo sapiens_hsa051310.45731522
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45660446
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45173789
94Melanoma_Homo sapiens_hsa052180.43663485
95Endometrial cancer_Homo sapiens_hsa052130.43146732
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39393313
97Pancreatic cancer_Homo sapiens_hsa052120.38884739
98Acute myeloid leukemia_Homo sapiens_hsa052210.38359574
99Metabolic pathways_Homo sapiens_hsa011000.38250342
100Renal cell carcinoma_Homo sapiens_hsa052110.36478854
101Non-small cell lung cancer_Homo sapiens_hsa052230.36010866
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35351424
103Wnt signaling pathway_Homo sapiens_hsa043100.35234402
104N-Glycan biosynthesis_Homo sapiens_hsa005100.34645537
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32857941
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31899056
107Sulfur relay system_Homo sapiens_hsa041220.30453398
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30314007
109Fructose and mannose metabolism_Homo sapiens_hsa000510.30202809
110Huntingtons disease_Homo sapiens_hsa050160.28755338
111AMPK signaling pathway_Homo sapiens_hsa041520.28355803
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.27611643
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.27465854
114FoxO signaling pathway_Homo sapiens_hsa040680.27232518
115Sulfur metabolism_Homo sapiens_hsa009200.24910811
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.24594044
117Galactose metabolism_Homo sapiens_hsa000520.20771865
118Fatty acid biosynthesis_Homo sapiens_hsa000610.20752262
119Arginine and proline metabolism_Homo sapiens_hsa003300.20550738
120Folate biosynthesis_Homo sapiens_hsa007900.20532456
121Alcoholism_Homo sapiens_hsa050340.19230266
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18718000
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17223042
124Glucagon signaling pathway_Homo sapiens_hsa049220.15925548
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13004919
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.11476355

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